TY - JOUR A1 - Diekmann, Martin A1 - Andres, Christian A1 - Becker, Thomas A1 - Bennie, Jonathan A1 - Blueml, Volker A1 - Bullock, James M. A1 - Culmsee, Heike A1 - Fanigliulo, Miriam A1 - Hahn, Annett A1 - Heinken, Thilo A1 - Leuschner, Christoph A1 - Luka, Stefanie A1 - Meissner, Justus A1 - Müller, Josef A1 - Newton, Adrian A1 - Peppler-Lisbach, Cord A1 - Rosenthal, Gert A1 - van den Berg, Leon J. L. A1 - Vergeer, Philippine A1 - Wesche, Karsten T1 - Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe JF - Journal of vegetation science N2 - Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species. KW - dry grasslands KW - fragmentation KW - homogenization KW - management KW - meta-analysis KW - nitrogen deposition KW - quasi-permanent plot KW - re-survey KW - species richness KW - wet grasslands Y1 - 2019 U6 - https://doi.org/10.1111/jvs.12727 SN - 1100-9233 SN - 1654-1103 VL - 30 IS - 2 SP - 187 EP - 202 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Riedel, Simona A1 - Siemiatkowska, Beata A1 - Watanabe, Mutsumi A1 - Müller, Christina S. A1 - Schünemann, Volker A1 - Hoefgen, Rainer A1 - Leimkühler, Silke T1 - The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - The mitochondrial ATP-binding cassette (ABC) transporters ABCB7 in humans, Atm1 in yeast and ATM3 in plants, are highly conserved in their overall architecture and particularly in their glutathione binding pocket located within the transmembrane spanning domains. These transporters have attracted interest in the last two decades based on their proposed role in connecting the mitochondrial iron sulfur (Fe–S) cluster assembly with its cytosolic Fe–S cluster assembly (CIA) counterpart. So far, the specific compound that is transported across the membrane remains unknown. In this report we characterized the ABCB7-like transporter Rcc02305 in Rhodobacter capsulatus, which shares 47% amino acid sequence identity with its mitochondrial counterpart. The constructed interposon mutant strain in R. capsulatus displayed increased levels of intracellular reactive oxygen species without a simultaneous accumulation of the cellular iron levels. The inhibition of endogenous glutathione biosynthesis resulted in an increase of total glutathione levels in the mutant strain. Bioinformatic analysis of the amino acid sequence motifs revealed a potential aminotransferase class-V pyridoxal-50-phosphate (PLP) binding site that overlaps with the Walker A motif within the nucleotide binding domains of the transporter. PLP is a well characterized cofactor of L-cysteine desulfurases like IscS and NFS1 which has a role in the formation of a protein-bound persulfide group within these proteins. We therefore suggest renaming the ABCB7-like transporter Rcc02305 in R. capsulatus to PexA for PLP binding exporter. We further suggest that this ABC-transporter in R. capsulatus is involved in the formation and export of polysulfide species to the periplasm. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 740 KW - ABCB7 KW - persulfide KW - polysulfide KW - glutathione KW - ABC transporter KW - Walker A motif KW - pyridoxal-50-phosphate Y1 - 1019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-434975 SN - 1866-8372 IS - 740 ER - TY - JOUR A1 - Blankertz, Benjamin A1 - Dornhege, Guido A1 - Krauledat, Matthias A1 - Müller, Klaus-Robert A1 - Kunzmann, Volker A1 - Losch, Florian A1 - Curio, Gabriel T1 - The Berlin brain-computer interface : EEG-based communication without subject training N2 - The Berlin Brain-Computer Interface (BBCI) project develops a noninvasive BCI system whose key features are 1) the use of well-established motor competences as control paradigms, 2) high-dimensional features from 128-channel electroencephalogram (EEG), and 3) advanced machine learning techniques. As reported earlier, our experiments demonstrate that very high information transfer rates can be achieved using the readiness potential (RP) when predicting the laterality of upcoming left-versus right-hand movements in healthy subjects. A more recent study showed that the RP similarily accompanies phantom movements in arm amputees, but the signal strength decreases with longer loss of the limb. In a complementary approach, oscillatory features are used to discriminate imagined movements (left hand versus right hand versus foot). In a recent feedback study with six healthy subjects with no or very little experience with BCI control, three subjects achieved an information transfer rate above 35 bits per minute (bpm), and further two subjects above 24 and 15 bpm, while one subject could not achieve any BCI control. These results are encouraging for an EEG-based BCI system in untrained subjects that is independent of peripheral nervous system activity and does not rely on evoked potentials even when compared to results with very well-trained subjects operating other BCI systems Y1 - 2006 UR - http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=7333 U6 - https://doi.org/10.1109/Tnsre.2006.875557 SN - 1534-4320 ER - TY - JOUR A1 - Laub, Julian A1 - Roth, Volker A1 - Buhmann, Joachim A1 - Müller, Klaus-Robert T1 - On the information and representation of non-Euclidean pairwise data N2 - Two common data representations are mostly used in intelligent data analysis, namely the vectorial and the pairwise representation. Pairwise data which satisfy the restrictive conditions of Euclidean spaces can be faithfully translated into a Euclidean vectorial representation by embedding. Non-metric pairwise data with violations of symmetry, reflexivity or triangle inequality pose a substantial conceptual problem for pattern recognition since the amount of predictive structural information beyond what can be measured by embeddings is unclear. We show by systematic modeling of non-Euclidean pairwise data that there exists metric violations which can carry valuable problem specific information. Furthermore, Euclidean and non-metric data can be unified on the level of structural information contained in the data. Stable component analysis selects linear subspaces which are particularly insensitive to data fluctuations. Experimental results from different domains support our pattern recognition strategy. Y1 - 2006 UR - http://www.sciencedirect.com/science/journal/00313203 U6 - https://doi.org/10.1016/j.patcog.2006.04.016 SN - 0031-3203 ER - TY - GEN A1 - Müller, Christina M. A1 - Schulz, Benjamin A1 - Lauterbach, Daniel A1 - Ristow, Michael A1 - Wissemann, Volker A1 - Gemeinholzer, Birgit T1 - Geropogon hybridus (L.) Sch.Bip. (Asteraceae) exhibits micro-geographic genetic divergence at ecological range limits along a steep precipitation gradient T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - We analyzed the population genetic pattern of 12 fragmented Geropogon hybridus ecological range edge populations in Israel along a steep precipitation gradient. In the investigation area (45 x 20 km(2)), the annual mean precipitation changes rapidly from 450 mm in the north (Mediterranean-influenced climate zone) to 300 mm in the south (semiarid climate zone) without significant temperature changes. Our analysis (91 individuals, 12 populations, 123 polymorphic loci) revealed strongly structured populations (AMOVA I broken vertical bar(ST) = 0.35; P < 0.001); however, differentiation did not change gradually toward range edge. IBD was significant (Mantel test r = 0.81; P = 0.001) and derived from sharply divided groups between the northernmost populations and the others further south, due to dispersal or environmental limitations. This was corroborated by the PCA and STRUCTURE analyses. IBD and IBE were significant despite the micro-geographic scale of the study area, which indicates that reduced precipitation toward range edge leads to population genetic divergence. However, this pattern diminished when the hypothesized gene flow barrier was taken into account. Applying the spatial analysis method revealed 11 outlier loci that were correlated to annual precipitation and, moreover, were indicative for putative precipitation-related adaptation (BAYESCAN, MCHEZA). The results suggest that even on micro-geographic scales, environmental factors play prominent roles in population divergence, genetic drift, and directional selection. The pattern is typical for strong environmental gradients, e.g., at species range edges and ecological limits, and if gene flow barriers and mosaic-like structures of fragmented habitats hamper dispersal. KW - environmental association studies KW - fragmented habitats KW - isolation by distance (IBD) KW - isolation by environment (IBE) KW - range edge populations Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427061 SN - 1866-8372 IS - 832 ER - TY - JOUR A1 - Tötzke, Christian A1 - Manke, Ingo A1 - Gaiselmann, Gerd A1 - Bohner, John A1 - Müller, Bernd R. A1 - Kupsch, Andreas A1 - Hentschel, Manfred P. A1 - Schmidt, Volker A1 - Banhart, Jens A1 - Lehnert, Werner T1 - A dedicated compression device for high resolution X-ray tomography of compressed gas diffusion layers JF - Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques N2 - We present an experimental approach to study the three-dimensional microstructure of gas diffusion layer (GDL) materials under realistic compression conditions. A dedicated compression device was designed that allows for synchrotron-tomographic investigation of circular samples under well-defined compression conditions. The tomographic data provide the experimental basis for stochastic modeling of nonwoven GDL materials. A plain compression tool is used to study the fiber courses in the material at different compression stages. Transport relevant geometrical parameters, such as porosity, pore size, and tortuosity distributions, are exemplarily evaluated for a GDL sample in the uncompressed state and for a compression of 30 vol.%. To mimic the geometry of the flow-field, we employed a compression punch with an integrated channel-rib-profile. It turned out that the GDL material is homogeneously compressed under the ribs, however, much less compressed underneath the channel. GDL fibers extend far into the channel volume where they might interfere with the convective gas transport and the removal of liquid water from the cell. (C) 2015 AIP Publishing LLC. Y1 - 2015 U6 - https://doi.org/10.1063/1.4918291 SN - 0034-6748 SN - 1089-7623 VL - 86 IS - 4 PB - American Institute of Physics CY - Melville ER - TY - BOOK A1 - Petermann, Renate A1 - Springborn, Peter-Volker A1 - Müller, Horst F. ED - Fontius, Martin T1 - Aufklärung III. : Deutschland und Spanien T3 - Das wissenschaftliche Werk / Werner Krauss Y1 - 1996 SN - 3-11-014547-2 VL - 3 PB - de Gruyter CY - Berlin ER - TY - JOUR A1 - Amendola, Luca A1 - Battaglia Mayer, Alexandra A1 - Capozziello, Salvatore A1 - Gottlöber, Stefan A1 - Müller, Volker A1 - Occhionero, Franco A1 - Schmidt, Hans-Jürgen T1 - Generalized sixth-order gravity and inflation JF - Preprint / Universität Potsdam, Fachbereich Mathematik Y1 - 1992 VL - 1992, 04 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Gottlöber, Stefan A1 - Schmidt, Hans-Jürgen A1 - Starobinsky, A. A. A1 - Müller, Volker T1 - Models of chaotic inflation JF - Preprint / Universität Potsdam, Fachbereich Mathematik Y1 - 1992 VL - 1992, 08 PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Riedel, Simona A1 - Siemiatkowska, Beata A1 - Watanabe, Mutsumi A1 - Müller, Christina S. A1 - Schünemann, Volker A1 - Hoefgen, Rainer A1 - Leimkühler, Silke T1 - The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species JF - Frontiers in Microbiology N2 - The mitochondrial ATP-binding cassette (ABC) transporters ABCB7 in humans, Atm1 in yeast and ATM3 in plants, are highly conserved in their overall architecture and particularly in their glutathione binding pocket located within the transmembrane spanning domains. These transporters have attracted interest in the last two decades based on their proposed role in connecting the mitochondrial iron sulfur (Fe–S) cluster assembly with its cytosolic Fe–S cluster assembly (CIA) counterpart. So far, the specific compound that is transported across the membrane remains unknown. In this report we characterized the ABCB7-like transporter Rcc02305 in Rhodobacter capsulatus, which shares 47% amino acid sequence identity with its mitochondrial counterpart. The constructed interposon mutant strain in R. capsulatus displayed increased levels of intracellular reactive oxygen species without a simultaneous accumulation of the cellular iron levels. The inhibition of endogenous glutathione biosynthesis resulted in an increase of total glutathione levels in the mutant strain. Bioinformatic analysis of the amino acid sequence motifs revealed a potential aminotransferase class-V pyridoxal-50-phosphate (PLP) binding site that overlaps with the Walker A motif within the nucleotide binding domains of the transporter. PLP is a well characterized cofactor of L-cysteine desulfurases like IscS and NFS1 which has a role in the formation of a protein-bound persulfide group within these proteins. We therefore suggest renaming the ABCB7-like transporter Rcc02305 in R. capsulatus to PexA for PLP binding exporter. We further suggest that this ABC-transporter in R. capsulatus is involved in the formation and export of polysulfide species to the periplasm. KW - ABCB7 KW - persulfide KW - polysulfide KW - glutathione KW - ABC transporter KW - Walker A motif KW - pyridoxal-50-phosphate Y1 - 2019 U6 - https://doi.org/10.3389/fmicb.2019.00406 SN - 1664-302X VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Müller, Christina Magdalena A1 - Huwe, Björn A1 - Wissemann, Volker A1 - Joshi, Jasmin Radha A1 - Gemeinholzer, Birgit T1 - Conservation genetic assessment of four plant species in a small replica of a steppe ecosystem >30 years after establishment JF - Biodiversity and conservation KW - Ex situ/in situ population genetic comparison KW - ISSR KW - Conservation genetics KW - Sand dune steppe and grassland vegetation KW - Botanic gardens Y1 - 2017 U6 - https://doi.org/10.1007/s10531-017-1381-1 SN - 0960-3115 SN - 1572-9710 VL - 26 SP - 2699 EP - 2716 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Maitrejean, Marie A1 - Wudick, Michael M. A1 - Völker, Camilla A1 - Prinsi, Bhakti A1 - Müller-Röber, Bernd A1 - Czempinski, Katrin A1 - Pedrazzini, Emanuela A1 - Vitale, Alessandro T1 - Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the Vacuole JF - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants N2 - The assembly, sorting signals, and turnover of the tonoplast potassium channel AtTPK1 of Arabidopsis (Arabidopsis thaliana) were studied. We used transgenic Arabidopsis expressing a TPK1-green fluorescent protein (GFP) fusion or protoplasts transiently transformed with chimeric constructs based on domain exchange between TPK1 and TPK4, the only TPK family member not located at the tonoplast. The results show that TPK1-GFP is a dimer and that the newly synthesized polypeptides transiently interact with a thus-far unidentified 20-kD polypeptide. A subset of the TPK1-TPK4 chimeras were unable to assemble correctly and these remained located in the endoplasmic reticulum where they interacted with the binding protein chaperone. Therefore, TPK1 must assemble correctly to pass endoplasmic reticulum quality control. Substitution of the cytosolic C terminus of TPK4 with the corresponding domain of TPK1 was sufficient to allow tonoplast delivery, indicating that this domain contains tonoplast sorting information. Pulse-chase labeling indicated that TPK1-GFP has a half-life of at least 24 h. Turnover of the fusion protein involves internalization into the vacuole where the GFP domain is released. This indicates a possible mechanism for the turnover of tonoplast proteins. Y1 - 2011 U6 - https://doi.org/10.1104/pp.111.177816 SN - 0032-0889 VL - 156 IS - 4 SP - 1783 EP - 1796 PB - American Society of Plant Physiologists CY - Rockville ER - TY - BOOK A1 - Thieken, Annegret A1 - Bessel, Tina A1 - Callsen, Ines A1 - Falter, Daniela A1 - Hasan, Issa A1 - Kienzler, Sarah A1 - Kox, Thomas A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Matthias, Max A1 - Meyer, Volker A1 - Mühr, Bernhard A1 - Müller, Meike A1 - Otto, Antje A1 - Pech, Ina A1 - Petrow, Theresia A1 - Pisi, Sebastian A1 - Rother, Karl-Heinz A1 - Schröter, Kai T1 - Das Hochwasser im Juni 2013 BT - Bewährungsprobe für das Hochwasserrisikomanagement in Deutschland T3 - Schriftenreihe des DKKV ; 53 Y1 - 2015 SN - 978-3-933181-62-6 PB - Deutsches Komitee Katastrophenvorsorge CY - Bonn ER - TY - JOUR A1 - Kuhlmann, Stella A1 - Tschorn, Mira A1 - Arolt, Volker A1 - Beer, Katja A1 - Brandt, Julia A1 - Grosse, Laura A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Rieckmann, Nina A1 - Waltenberger, Johannes A1 - Warnke, Katharina A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients BT - a prospective study JF - Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology N2 - Objective: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. Methods: At baseline, N = 225 CHD patients were enrolled while hospitalized. Of these, N = 190 (84%) could be followed up 6 months later. Depressive symptoms were assessed both at baseline and at the 6-months follow-up using the Patient Health Questionnaire (PHQ-9). Serum BDNF concentrations were measured using fluorometric Enzyme-linked immunosorbent assays (ELISA). Results: Logistic regression models showed that lower BDNF levels were associated with persistent depressive symptoms, even after adjustment for age, sex, smoking and potential medical confounders. The incidence of depressive symptoms was not related to lower BDNF levels. However, somatic comorbidity (as measured by the Charlson Comorbidity Index) was significantly associated with the incidence of depressive symptoms. Conclusions: Our findings suggest a role of BDNF in the link between CHD and depressive symptoms. Particularly, low serum BDNF levels could be considered as a valuable biomarker for the persistence of depressive symptoms among depressed CHD patients. KW - Brain-derived neurotrophic factor (BDNF) KW - Coronary heart disease (CHD) KW - Depression KW - Serum Y1 - 2016 U6 - https://doi.org/10.1016/j.psyneuen.2016.12.015 SN - 0306-4530 VL - 77 SP - 196 EP - 202 PB - Elsevier Science CY - Oxford ER - TY - GEN A1 - Tschorn, Mira A1 - Kuhlmann, Stella Linnea A1 - Rieckmann, Nina A1 - Beer, Katja A1 - Grosse, Laura A1 - Arolt, Volker A1 - Waltenberger, Johannes A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 850 KW - depression KW - BDNF KW - coronary heart disease KW - heart failure KW - somatic comorbidity KW - acute coronary syndrome Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557315 SN - 1866-8364 IS - 1 ER - TY - JOUR A1 - Tschorn, Mira A1 - Kuhlmann, Stella Linnea A1 - Rieckmann, Nina A1 - Beer, Katja A1 - Grosse, Laura A1 - Arolt, Volker A1 - Waltenberger, Johannes A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease JF - Acta Neuropsychiatrica N2 - Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF. KW - depression KW - BDNF KW - coronary heart disease KW - heart failure KW - somatic comorbidity KW - acute coronary syndrome Y1 - 2020 U6 - https://doi.org/10.1017/neu.2020.31 SN - 1601-5215 SN - 0924-2708 VL - 33 IS - 1 SP - 22 EP - 30 PB - Cambridge Univ. Press CY - Cambridge ER - TY - JOUR A1 - Auer, Cornelia A1 - Kriegler, Elmar A1 - Carlsen, Henrik A1 - Kok, Kasper A1 - Pedde, Simona A1 - Krey, Volker A1 - Müller, Boris T1 - Climate change scenario services BT - from science to facilitating action JF - One earth N2 - The goal of limiting global warming to well below 2°C as set out in the Paris Agreement calls for a strategic assessment of societal pathways and policy strategies. Besides policy makers, new powerful actors from the private sector, including finance, have stepped up to engage in forward-looking assessments of a Paris-compliant and climate-resilient future. Climate change scenarios have addressed this demand by providing scientific insights on the possible pathways ahead to limit warming in line with the Paris climate goal. Despite the increased interest, the potential of climate change scenarios has not been fully unleashed, mostly due to a lack of an intermediary service that provides guidance and access to climate change scenarios. This perspective presents the concept of a climate change scenario service, its components, and a prototypical implementation to overcome this shortcoming aiming to make scenarios accessible to a broader audience of societal actors and decision makers. KW - climate change scenarios KW - climate change scenario services KW - climate services KW - co-production KW - visualization KW - capacity building KW - mitigation scenarios KW - adaptation scenarios KW - impact projections Y1 - 2021 U6 - https://doi.org/10.1016/j.oneear.2021.07.015 SN - 2590-3322 SN - 2590-3330 VL - 4 IS - 8 SP - 1074 EP - 1082 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tschorn, Mira A1 - Rieckmann, Nina A1 - Arolt, Volker A1 - Beer, Katja A1 - Haverkamp, Wilhelm A1 - Martus, Peter A1 - Waltenberger, Johannes A1 - Müller-Nordhorn, Jacqueline A1 - Ströhle, Andreas T1 - Erkennungsgüte dreier deutschsprachiger Screeninginstrumente für Depression bei hospitalisierten Patienten mit koronarer Herzerkrankung T1 - Diagnostic Accuracy of German Depression Screenings in Patients with Coronary Heart Disease JF - Psychiatrische Praxis N2 - Ziel Vergleich der Erkennungsgüte von drei Depressions-Screeninginstrumenten bei Patienten mit koronarer Herzerkrankung (KHK). Methodik 1019 KHK-Patienten erhielten den Patient Health Questionnaire (PHQ-9 und PHQ-2) und die Hospital Anxiety and Depression Scale (HADS-D) sowie ein klinisches Interview (Composite International Diagnostic Interview) als Referenzstandard. Ergebnisse Bezüglich der Erkennungsgüte waren PHQ-9 und HADS-D dem PHQ-2 überlegen. Optimale Cut-off-Werte waren 7 (PHQ-9 und HADS-D) und 2 (PHQ-2). Schlussfolgerung PHQ-9 und HADS-D haben eine vergleichbare Diskriminationsfähigkeit für depressive Störungen bei KHK-Patienten. N2 - Objective To compare the diagnostic accuracy of German depression screening instruments in patients with coronary heart disease (CHD). Methods 1019 CHD patients completed the Patient Health Questionnaire (PHQ-9 and PHQ-2) and the Hospital Anxiety and Depression Scale (HADS-D). The Composite International Diagnostic Interview served as reference standard for "any depressive disorder" and "major depression". Results The accuracy of the PHQ-9 and the HADS-D was comparable according to the area under the curve, and both were superior to the PHQ-2. The optimal cut-off according to the Youden index (maximum sum of sensitivity and specificity) was 7 for both instruments. At this optimal cut-off, the PHQ-9 had a higher sensitivity compared to the HADS-D, but a lower specificity (below 68). Results remained similar when patients who reported that they currently underwent treatment for depression were excluded. Conclusion The PHQ-9 and the HADS-D have comparable overall diagnostic accuracy in CHD patients. In line with previous screening studies with CHD patients, the optimal cut-offs were below the cut-offs that are recommended in the literature. KW - coronary artery disease KW - depression KW - diagnosis KW - screening KW - validity Y1 - 2019 U6 - https://doi.org/10.1055/s-0042-123434 SN - 0303-4259 SN - 1439-0876 VL - 46 IS - 1 SP - 41 EP - 48 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Li, Shuang A1 - Abdulkadir, Nafi'u A1 - Schattenberg, Florian A1 - da Rocha, Ulisses Nunes A1 - Grimm, Volker A1 - Müller, Susann A1 - Liu, Zishu T1 - Stabilizing microbial communities by looped mass transfer JF - Proceedings of the National Academy of Sciences of the United States of America : PNAS N2 - Building and changing a microbiome at will and maintaining it over hundreds of generations has so far proven challenging. Despite best efforts, complex microbiomes appear to be susceptible to large stochastic fluctuations. Current capabilities to assemble and control stable complex microbiomes are limited. Here, we propose a looped mass transfer design that stabilizes microbiomes over long periods of time. Five local microbiomes were continuously grown in parallel for over 114 generations and connected by a loop to a regional pool. Mass transfer rates were altered and microbiome dynamics were monitored using quantitative high-throughput flow cytometry and taxonomic sequencing of whole communities and sorted subcommunities. Increased mass transfer rates reduced local and temporal variation in microbiome assembly, did not affect functions, and overcame stochasticity, with all microbiomes exhibiting high constancy and increasing resistance. Mass transfer synchronized the structures of the five local microbiomes and nestedness of certain cell types was eminent. Mass transfer increased cell number and thus decreased net growth rates mu'. Subsets of cells that did not show net growth mu'SCx were rescued by the regional pool R and thus remained part of the microbiome. The loop in mass transfer ensured the survival of cells that would otherwise go extinct, even if they did not grow in all local microbiomes or grew more slowly than the actual dilution rate D would allow. The rescue effect, known from metacommunity theory, was the main stabilizing mechanism leading to synchrony and survival of subcommunities, despite differences in cell physiological properties, including growth rates. KW - microbial ecology KW - metacommunity assembly KW - stability KW - microbial KW - community cytometry KW - single-cell analytics Y1 - 2022 U6 - https://doi.org/10.1073/pnas.2117814119 SN - 1091-6490 VL - 119 IS - 17 PB - National Acad. of Sciences CY - Washington ER -