TY - JOUR A1 - Jäckel, Annemarie A1 - Frank, Ulrike T1 - Effekte des Mendelsohn Manövers auf die Atem-Schluck-Koordination : eine Untersuchung der intra- individuellen Variation bei gesunden Erwachsenen Y1 - 2012 ER - TY - GEN A1 - Jäckel, Annemarie A1 - Frank, Ulrike T1 - Effekte des Mendelsohn Manövers auf die Atem-Schluck-Koordination : eine Untersuchung der intra-individuellen Variation bei gesunden Erwachsenen N2 - 1 Einleitung 2 Fragestellungen 3 Methode 4 Ergebnisse und Diskussion 5 Literatur KW - Patholinguistik KW - Sprachtherapie KW - Dysphagie KW - Schluckstörung KW - Schlucktherapie KW - patholinguistics KW - speech/language therapy KW - dysphagia KW - swallowing disorders KW - dysphagia therapy Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62491 ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich T1 - Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79873 SP - 235 EP - 237 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Vogel, Annemarie A1 - Claus, Inga A1 - Ahring, Sigrid A1 - Gruber, Doreen A1 - Haghikia, Aiden A1 - Frank, Ulrike A1 - Dziewas, Rainer A1 - Ebersbach, Georg A1 - Gandor, Florin A1 - Warnecke, Tobias T1 - Endoscopic characteristics of dysphagia in multiple system atrophy JF - Movement disorders : official journal of the Movement Disorder Society N2 - Background Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. Objective This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. Methods Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings. Results Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4%, piecemeal deglutition, 75.4%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9%; penetration/aspiration, 28.1%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8%, P < 0.001; piecemeal deglutition, 1.8%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85%, specificity 100%). Conclusions In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia. KW - multiple system atrophy KW - dysphagia KW - FEES KW - Swallowing Disturbance Questionnaire KW - SDQ Y1 - 2022 U6 - https://doi.org/10.1002/mds.28854 SN - 0885-3185 SN - 1531-8257 VL - 37 IS - 3 SP - 535 EP - 544 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Leitner, Ulrike A1 - Baron, Frank A1 - Clark, Rex A1 - Doherr, Detlev A1 - Griep, Wolfgang A1 - Schnöpf, Markus ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - HiN : Alexander von Humboldt im Netz = Humboldt Digital Library N2 - - Ulrike Leitner: Einleitung - Frank Baron: From Alexander von Humboldt to Frederic Edwin Church: Voyages of Scientific Exploration and Artistic Creativity - Rex Clark: Alexander von Humboldt‘s Images of Landscape and the ‚Chaos of the Poets - Detlev Doherr: The Humboldt Digital Library: Exploring Innovative Structures - Wolfgang Griep: Die Bedeutung der Umkreisquellen für Alexander von Humboldts südamerikanische Reise - Ulrike Leitner: Vielschichtigkeit und Komplexität im Reisewerk Alexander von Humboldts – Bibliographischer Hintergrund - Markus Schnoepf: El Proyecto Humboldt: Una biblioteca digital para las expediciones científicas a las Islas Canarias T3 - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies - VI.2005, 10 KW - bildende Kunst KW - Frederic Edwin Church KW - Humboldt als Vorbild KW - Gottfried August Bürger KW - Italienische Reise KW - Johann Wolfgang von Goethe KW - Münchhausen KW - Elektronische Edition KW - Google KW - Humboldt Digital Library KW - Pflanzengeographie KW - Volltext KW - Orinoco KW - Relation historique KW - Umkreisquellen KW - 1799-1804 KW - Bibliographie KW - Multilingualität KW - Netzwerke des Wissens KW - Ottmar Ette KW - 1700-1900 KW - Digital Library KW - Islas Canarias KW - Proyecto Humboldt Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-35175 SN - 1617-5239 SN - 2568-3543 N1 - Mit freundlicher Unterstützung von der Stiftung Deutsch-Amerikanisches Konzil – German-American Academic Council Foundation (TRANSCOOP) – a program supporting Transatlantic research among German, U. S., and/or Canadian Scholars in the humanities, social sciences, economic, and law. VL - VI IS - 10 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ette, Ottmar A1 - Knobloch, Eberhard A1 - Schwarz, Oliver A1 - Werner, Petra A1 - Suckow, Christian A1 - Jobst, Anne A1 - Schmuck, Thomas A1 - Ringmacher, Manfred A1 - Tintemann, Ute A1 - Leitner, Ulrike A1 - Holl, Frank A1 - Panwitz, Sebastian A1 - Péaud, Laura A1 - Holtz, Bärbel A1 - Folkerts, Menso A1 - Päßler, Ulrich A1 - Roba, Bill ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - HiN : Alexander von Humboldt im Netz = Ingo Schwarz zum 65. Geburtstag T2 - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - Inhalt: Alexander von Humboldt-Forschungsstelle: Ingo Schwarz zum 65. Geburtstag Ottmar Ette: Findung und Erfindung einer Leserschaft. Neuere Editionsprojekte zu Alexander von Humboldt als Grundlage und Herausforderung künftigen Forschens Eberhard Knobloch: Alexandre de Humboldt et le Marquis de Laplace Oliver Schwarz: Alexander von Humboldt als astronomischer Arbeiter, Diskussionspartner und Ideengeber Petra Werner: Innenwelten und bleiche Gärten. Alexander von Humboldt untertage und in der Caripe-Höhle Christian Suckow: Alexander von Humboldt in Ust’-Kamenogorsk Anne Jobst: Neue Briefe Christian Gottfried Ehrenbergs an Alexander von Humboldt Thomas Schmuck: Humboldt, Baer und die Evolution Manfred Ringmacher: Zwei Briefe auf Guaraní in Alexander von Humboldts Handschrift Ute Tintemann: Julius Klaproths Mithridates-Projekt, Alexander von Humboldt und das Verlagshaus Cotta Ulrike Leitner: „Ja! Wenn Berlin Bonn wäre!“ Friedrich Rückerts Berufung nach Berlin Frank Holl: „Zur Freiheit bestimmt“ – Alexander von Humboldts Blick auf die Kulturen der Welt Sebastian Panwitz: Das Humboldt-Mendelssohn-Haus Jägerstraße 22. Ein Quellenfund Laura Péaud: Du Mexique à l‘Oural : l‘expertise humboldtienne au service du politique Bärbel Holtz: „Cicerone“ des Königs? Alexander von Humboldt und Friedrich Wilhelm III. Menso Folkerts: Ein unerwartetes Zusammentreffen in Sanssouci. Alexander von Humboldt und Karl Ludwig Hencke an der Tafel Friedrich Wilhelms IV. Ulrich Päßler: Preußens Mann in Washington. Fünf Briefe Friedrich von Gerolts an Alexander von Humboldt (1858/1859) Bill Roba: German-Iowan Strategies in Celebrating the Centennial of Alexander von Humboldt’s Birth Regina Mikosch: Ingo Schwarz‘ Veröffentlichungen zur Alexander von Humboldt Über die Autoren T3 - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies - XV.2014, 29 KW - Humboldt KW - Alexander von Humboldt KW - Humboldt-Forschung KW - Universität Potsdam KW - BBAW KW - Brief KW - Briefwechsel KW - Editionsprojekte KW - Reisemanuskripte KW - Reisetagebücher KW - amerikanische Reisetagebücher KW - Marquis de Laplace KW - Laplace KW - Astronomie KW - Caripe KW - untertage KW - Höhlenforschung KW - Ust'-Kamenogorsk KW - Christian Gottfried Ehrenberg KW - Baer KW - Evolution KW - Guaraní KW - Julius Klaproth KW - Mithriades KW - Cotta KW - Bonn KW - Berlin KW - Friedrich Rückert KW - Kulturen der Welt KW - Freiheit KW - Sklaverei KW - Abolitionismus KW - Mendelssohn KW - Jägerstraße 22 KW - Mexiko KW - Mexico KW - Neu-Spanien KW - Nouvelle Espagne KW - Oural KW - Ural KW - Politik KW - Friedrich Wilhelm III. KW - Preußen KW - Sanssouci KW - Karl Ludwig Hencke KW - Friedrich Wilhelm IV. KW - Washington D.C. KW - Friedrich von Gerolt KW - Iowa KW - Hundertjahr-Feier KW - Gedenkfeier KW - US-Rezeption KW - Ingo Schwarz Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-85033 SN - 1617-5239 SN - 2568-3543 VL - XV IS - 29 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Engemaier, Eva A1 - Koch, Sina A1 - Böer, Ulrike A1 - Püschel, Gerhard Paul T1 - Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor N2 - Prostanoid receptors belong to the class of heptahelical plasma membrane receptors. For the five prostanoids, eight receptor subtypes have been identified. They display an overall sequence similarity of roughly 30%. Based on sequence comparison, single amino acids in different subtypes of different species have previously been identified by site-directed mutagenesis or in hybrid receptors that appear to be essential for ligand binding or G-protein coupling. Based on this information, a series of mutants of the human FP receptor was generated and characterized in ligand- binding and second-messenger-formation studies. It was found that mutation of His-81 to Ala in transmembrane domain 2 and of Arg-291 to Leu in transmembrane domain 7, which are putative interaction partners for the prostanoid's carboxyl group, abolished ligand binding. Mutants in which Ser-263 in transmembrane domain 6 or Asp-300 in transmembrane domain 7 had been replaced by Ala or Gln, respectively, no longer discriminated between prostaglandins PGF(2alpha) and PGD(2). Thus distortion of the topology of transmembrane domains 6 and 7 appears to interfere with the cyclopentane ring selectivity of the receptor. PGF(2alpha)-induced inositol formation was strongly reduced in the mutant Asp-300Gln, inferring a role for this residue in agonist-induced G-protein activation. Y1 - 2003 UR - http://www.biochemj.org/bj/371/0443/bj3710443.htm ER - TY - JOUR A1 - Frank, Ulrike A1 - van den Engel-Hoek, Lenie A1 - Nogueira, Dalia A1 - Schindler, Antonio A1 - Adams, Sasha A1 - Curry, Morgan A1 - Huckabee, Maggie-Lee T1 - International standardisation of the test of masticating and swallowing solids in children JF - Journal of oral rehabilitation N2 - The Test of Masticating and Swallowing Solids (TOMASS) is a validated assessment tool measuring the efficiency of solid bolus intake by four quantitative parameters: discrete bites, masticatory cycles, swallows and time to ingest a single cracker. A normative database for adults (20-80+ years) has previously been established. The objective of this study was to investigate the applicability and reliability of the TOMASS in children and adolescents (TOMASS-C) and to establish the normative database for this younger population. We collected data from 638 participants (male: 311, female: 327) in five age groups (4-18 years) with five different but very similar test crackers in four countries. Significant effects of bolus type (cracker), age group and gender on the TOMASS parameters were identified, requiring stratification of the TOMASS-C database by these variables. Intra-rater reliability was excellent (ICC > 0.94) for all parameters; inter-rater reliability was moderate for "number of swallows" (ICC = 0.54), good for "bites" (ICC = 0.78) and "time" (ICC = 0.82), and excellent for "masticatory cycles" (ICC = 0.96). The "Test of Masticating and Swallowing Solids in Children (TOMASS-C)" was identified to be a reliable diagnostic tool for the comprehensive measurement of discrete oral stage components of solid bolus ingestion, standardised by a large normative database that covers age groups from preschoolers to young adults. While differences between gender groups were less pronounced than in the adult population, previous results relating to changes in masticatory and swallowing as a function of age are confirmed by our data. KW - mastication KW - normative data KW - reliability KW - solid bolus KW - swallowing Y1 - 2018 U6 - https://doi.org/10.1111/joor.12728 SN - 0305-182X SN - 1365-2842 VL - 46 IS - 2 SP - 161 EP - 169 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Müller, Nina A1 - Beer, Carola de A1 - Frank, Ulrike T1 - Ist die therapeutische Mundpflege bei Dysphagiepatient*innen verschwendete Zeit? BT - ein narrativer Review zu Effekten der Mundpflege auf die Pneumoniehäufigkeit und Ableitung einer Handlungsempfehlung BT - a narrative review on the effects of oral care on pneumonia risk and guidelines for an effective and structured approach JF - Sprache, Stimme, Gehör : Zeitschrift für Kommunikationsstörungen N2 - Aspirationspneumonien sind eine häufige Todesursache bei Dysphagiepatient*innen. In diesem Beitrag wird durch die Evaluation relevanter Studien die Frage untersucht, ob die therapeutische Mundpflege bei Dysphagiepatient*innen zur Verringerung des Pneumonierisikos beitragen kann. Zudem wird auf dieser Grundlage eine Handlungsempfehlung für die Umsetzung der Mundpflege entwickelt. Die ausgewählten Studien zeigen, dass die Mundpflege einen positiven Effekt auf das Pneumonie-Risiko von Dysphagiepatient*innen hat. Sie sollte auf den Grundsätzen Einfachheit, Sicherheit, Arbeitskräfteentlastung, Wirksamkeit, Universalität, Wirtschaftlichkeit und vollständige Mundpflege aller Teile der Mundhöhle beruhen und nimmt weniger als fünf Minuten täglich ein. Sie bereitet durch die taktile Stimulation auf die anschließende Dysphagie-Therapie vor und ist somit sinnvoll investierte Therapiezeit. N2 - Aspiration pneumonia is a common cause of death in dysphagia patients. In this review, we investigate whether a structured oral care approach can help to reduce pneumonia risk in dysphagic patients. In addition, guidelines for the implementation of oral care on the basis of the analyzed studies are presented. Oral care has positive effects on the risk of pneumonia in dysphagia patients. Oral care should be based on the principles of simplicity, safety, efficiency and effectiveness, universality and economy and it should include all parts of the oral cavity. Effective oral care takes less than five minutes a day. The tactile stimulation prepares the patient for dysphagia therapy and can be considered wisely-invested time. T2 - Is oral care for dysphagic patients wasted time? KW - oral care KW - dysphagia KW - pneumonia KW - Therapeutische Mundpflege KW - Dysphagie KW - Pneumonie Y1 - 2022 U6 - https://doi.org/10.1055/a-1714-1587 SN - 0342-0477 SN - 1439-1260 VL - 46 IS - 03 SP - 150 EP - 155 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Opitz, Stephan A1 - Wünnemann, Bernd A1 - Aichner, Bernhard A1 - Dietze, Elisabeth A1 - Hartmann, Kai A1 - Herzschuh, Ulrike A1 - IJmker, Janneke A1 - Lehmkuhl, Frank A1 - Li, Shijie A1 - Mischke, Steffen A1 - Plotzki, Anna A1 - Stauch, Georg A1 - Diekmann, Bernhard T1 - Late Glacial and Holocene development of Lake Donggi Cona, north-eastern Tibetan Plateau, inferred from sedimentological analysis JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - Sediments of Lake Donggi Cona on the northeastern Tibetan Plateau were studied to infer changes in the lacustrine depositional environment, related to climatic and non-climatic changes during the last 19 kyr. The lake today fills a 30x8 km big and 95 m deep tectonic basin, associated with the Kunlun Fault. The study was conducted on a sediment-core transect through the lake basin, in order to gain a complete picture of spatio-temporal environmental change. The recovered sediments are partly finely laminated and are composed of calcareous muds with variable amounts of carbonate micrite, organic matter, detrital silt and clay. On the basis of sedimentological, geochemical, and mineralogical data up to five lithological units (LU) can be distinguished that document distinct stages in the development of the lake system. The onset of the lowermost LU with lacustrine muds above basal sands indicates that lake level was at least 39 m below the present level and started to rise after 19 ka, possibly in response to regional deglaciation. At this time, the lacustrine environment was characterized by detrital sediment influx and the deposition of siliciclastic sediment. In two sediment cores, upward grain-size coarsening documents a lake-level fall after 13 cal ka BP, possibly associated with the late-glacial Younger Dryas stadial. From 11.5 to 4.3 cal ka BP, grain-size fining in sediment cores from the profundal coring sites and the onset of lacustrine deposition at a litoral core site (2 m water depth) in a recent marginal bay of Donggi Cona document lake-level rise during the early to mid-Holocene to at least modern level. In addition, high biological productivity and pronounced precipitation of carbonate micrites are consistent with warm and moist climate conditions related to an enhanced influence of summer monsoon. At 4.3 cal ka BP the lake system shifted from an aragonite- to a calcite-dominated system, indicating a change towards a fully open hydrological lake system. The younger clay-rich sediments are moreover non-laminated and lack any diagenetic sulphides, pointing to fully ventilated conditions, and the prevailing absence of lake stratification. This turning point in lake history could imply either a threshold response to insolation-forced climate cooling or a response to a non-climatic trigger, such as an erosional event or a tectonic pulse that induced a strong earthquake, which is difficult to decide from our data base. KW - China KW - Monsoon KW - Paleolimnology KW - Multi-site study KW - Aragonite KW - XRF KW - XRD KW - Sedimentology Y1 - 2012 U6 - https://doi.org/10.1016/j.palaeo.2012.04.013 SN - 0031-0182 VL - 337 IS - 23 SP - 159 EP - 176 PB - Elsevier CY - Amsterdam ER -