TY - JOUR A1 - van der Valk, Ralf J. P. A1 - Kreiner-Moller, Eskil A1 - Kooijman, Marjolein N. A1 - Guxens, Monica A1 - Stergiakouli, Evangelia A1 - Saaf, Annika A1 - Bradfield, Jonathan P. A1 - Geller, Frank A1 - Hayes, M. Geoffrey A1 - Cousminer, Diana L. A1 - Koerner, Antje A1 - Thiering, Elisabeth A1 - Curtin, John A. A1 - Myhre, Ronny A1 - Huikari, Ville A1 - Joro, Raimo A1 - Kerkhof, Marjan A1 - Warrington, Nicole M. A1 - Pitkanen, Niina A1 - Ntalla, Ioanna A1 - Horikoshi, Momoko A1 - Veijola, Riitta A1 - Freathy, Rachel M. A1 - Teo, Yik-Ying A1 - Barton, Sheila J. A1 - Evans, David M. A1 - Kemp, John P. A1 - St Pourcain, Beate A1 - Ring, Susan M. A1 - Smith, George Davey A1 - Bergstrom, Anna A1 - Kull, Inger A1 - Hakonarson, Hakon A1 - Mentch, Frank D. A1 - Bisgaard, Hans A1 - Chawes, Bo Lund Krogsgaard A1 - Stokholm, Jakob A1 - Waage, Johannes A1 - Eriksen, Patrick A1 - Sevelsted, Astrid A1 - Melbye, Mads A1 - van Duijn, Cornelia M. A1 - Medina-Gomez, Carolina A1 - Hofman, Albert A1 - de Jongste, Johan C. A1 - Taal, H. Rob A1 - Uitterlinden, Andre G. A1 - Armstrong, Loren L. A1 - Eriksson, Johan A1 - Palotie, Aarno A1 - Bustamante, Mariona A1 - Estivill, Xavier A1 - Gonzalez, Juan R. A1 - Llop, Sabrina A1 - Kiess, Wieland A1 - Mahajan, Anubha A1 - Flexeder, Claudia A1 - Tiesler, Carla M. T. A1 - Murray, Clare S. A1 - Simpson, Angela A1 - Magnus, Per A1 - Sengpiel, Verena A1 - Hartikainen, Anna-Liisa A1 - Keinanen-Kiukaanniemi, Sirkka A1 - Lewin, Alexandra A1 - Alves, Alexessander Da Silva Couto A1 - Blakemore, Alexandra I. F. A1 - Buxton, Jessica L. A1 - Kaakinen, Marika A1 - Rodriguez, Alina A1 - Sebert, Sylvain A1 - Vaarasmaki, Marja A1 - Lakka, Timo A1 - Lindi, Virpi A1 - Gehring, Ulrike A1 - Postma, Dirkje S. A1 - Ang, Wei A1 - Newnham, John P. A1 - Lyytikainen, Leo-Pekka A1 - Pahkala, Katja A1 - Raitakari, Olli T. A1 - Panoutsopoulou, Kalliope A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Groen-Blokhuis, Maria A1 - Ilonen, Jorma A1 - Franke, Lude A1 - Hirschhorn, Joel N. A1 - Pers, Tune H. A1 - Liang, Liming A1 - Huang, Jinyan A1 - Hocher, Berthold A1 - Knip, Mikael A1 - Saw, Seang-Mei A1 - Holloway, John W. A1 - Melen, Erik A1 - Grant, Struan F. A. A1 - Feenstra, Bjarke A1 - Lowe, William L. A1 - Widen, Elisabeth A1 - Sergeyev, Elena A1 - Grallert, Harald A1 - Custovic, Adnan A1 - Jacobsson, Bo A1 - Jarvelin, Marjo-Riitta A1 - Atalay, Mustafa A1 - Koppelman, Gerard H. A1 - Pennell, Craig E. A1 - Niinikoski, Harri A1 - Dedoussis, George V. A1 - Mccarthy, Mark I. A1 - Frayling, Timothy M. A1 - Sunyer, Jordi A1 - Timpson, Nicholas J. A1 - Rivadeneira, Fernando A1 - Bonnelykke, Klaus A1 - Jaddoe, Vincent W. V. T1 - A novel common variant in DCST2 is associated with length in early life and height in adulthood JF - Human molecular genetics N2 - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height. Y1 - 2015 U6 - https://doi.org/10.1093/hmg/ddu510 SN - 0964-6906 SN - 1460-2083 VL - 24 IS - 4 SP - 1155 EP - 1168 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Oppermann, Martin A1 - Möller, Ulrike A1 - Böer, Ulrike A1 - Püschel, Gerhard Paul T1 - Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid N2 - Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R. Y1 - 1999 SN - 1521-0111 ER - TY - JOUR A1 - Thonicke, Mady A1 - Frank, Ulrike T1 - Biofeedback in der Dysphagietherapie BT - Unterstützung therapeutischer Maßnahmen durch Oberflächen-Elektromyographie (sEMG) JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79891 SP - 243 EP - 247 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin T1 - COVID-19 BT - neue Herausforderungen in der Dysphagie- und Atemtherapie BT - new challenges in dysphagia and respiratory therapy JF - Der Nervenarzt : Organ der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft für Neurologie N2 - Eine COVID-19-Erkrankung kann zu schweren Krankheitsverläufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschränkungen führen. Schluckstörungen (Dysphagien) können in dieser Patientengruppe durch primäre Schädigungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die häufig längere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID“), sodass die Patienten auch längerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme benötigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivität und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem müssen Auswahl und Durchführungsintensität therapeutischer Maßnahmen an die Kapazitäten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern. N2 - Coronavirus disease 2019 (COVID-19) can lead to severe disease courses with multiple organ involvement, respiratory and neurological functional impairments. Swallowing disorders (dysphagia) in this patient group can result from primary damage to the central and peripheral neuronal swallowing network but also from the frequently prolonged intensive care treatment and mechanical ventilation. Clinical observations indicate persistence of dysphagia in post-acute COVID-19 syndrome (long COVID), so that these patients probably also need long-term interventions for rehabilitation of safe and sufficient oral feeding. Therefore, structured disease-specific monitoring of dysphagia symptoms should be integrated into the treatment of COVID-19 patients and respiratory therapy should be an essential part of dysphagia management to re-establish cough effectiveness and breathing-swallowing coordination. Challenges arise from necessary adjustments to established treatment standards to prevent infections. Furthermore, the selection and intensity of therapeutic measures have to be adapted to the capacities and the specific pathophysiology of COVID-19 and long COVID patients to prevent further functional deterioration. KW - Long COVID KW - Fatigue KW - Post intensive care syndrome (PICS) KW - Laryngeal functions KW - Laryngeale Funktionen KW - Hypoxemia KW - Hypoxämie KW - Long-COVID Y1 - 2021 U6 - https://doi.org/10.1007/s00115-021-01162-5 SN - 0028-2804 SN - 1433-0407 VL - 93 IS - 2 SP - 167 EP - 174 PB - Springer CY - New York ER - TY - JOUR A1 - Düsterhöft, Stefanie A1 - Frank, Ulrike T1 - Das PNF-Konzept BT - Anwendung in der orofacialen Therapie JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54306 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 171 EP - 183 ER - TY - JOUR A1 - Düsterhöft, Stefanie A1 - Frank, Ulrike T1 - Das PNF-Konzept Anwendung in der orofacialen Therapie Y1 - 2011 ER - TY - JOUR A1 - Sticher, Heike A1 - Czepluch, Christine A1 - Mätzener, Flurina A1 - Wilmes, Stefanie A1 - Hadert, Sandra A1 - Frank, Ulrike A1 - Mäder, Mark T1 - Dekanülierungsmanagement bei Patienten mit respiratorischen Beeinträchtigungen und Dysphagie JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54277 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 141 EP - 142 ER - TY - JOUR A1 - Sticher, Heike A1 - Czepluch, Christine A1 - Mätzener, Flurina A1 - Wilmes, Stefanie A1 - Hadert, Sandra A1 - Frank, Ulrike A1 - Mäder, Mark T1 - Dekanülierungsmanagment bei Patienten mit respiratorischen Beeinträchtigungen und Dysphagie Y1 - 2011 ER - TY - JOUR A1 - Posse, Dorothea A1 - Frank, Ulrike T1 - Der Einfluss des Lee Silverman Voice Treatment (LSVT) auf die Hypernasalität bei Dysarthrie JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54313 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 185 EP - 187 ER - TY - JOUR A1 - Posse, Dorothea A1 - Frank, Ulrike T1 - Der Einfluss des Lee Silverman Voice Treatment (LSVT) auf die Hypernasalität bei Dysarthrie Y1 - 2011 ER - TY - JOUR A1 - Peiffers, Sabine A1 - Frank, Ulrike T1 - Der Einfluss von Körperparametern auf das Schluckvolumen bei gesunden Erwachsenen JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79882 SP - 239 EP - 242 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Puritz, Caroline A1 - Seidl, Rainer Ottis A1 - Frank, Ulrike T1 - Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repräsentation der Schluckmuskulatur bei Patienten mit Morbus Parkinson Y1 - 2011 ER - TY - JOUR A1 - Puritz, Caroline A1 - Seidl, Rainer Ottis A1 - Frank, Ulrike T1 - Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repräsentationen der Schluckmuskulatur bei Patienten mit Morbus Parkinson JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54322 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 189 EP - 191 ER - TY - THES A1 - Frank, Ulrike T1 - Die Behandlung tracheotomierter Patienten mit schwerer Dysphagie : eine explorative Studie zur Evaluation eines interdisziplinären Interventionsansatzes T1 - Treating tracheotomized patients with severe dysphagia : an explorative evaluation of a multidisciplinary treatment protocol N2 - In der neurologischen Rehabilitation werden in zunehmendem Maße tracheotomierte Patienten mit schweren Dysphagien behandelt. Daher sollte den hierzu bisher entwickelten Interventionsverfahren eine evidenzbasierte Grundlage gegeben werden. In der vorliegenden Arbeit wird ein multidisziplinärer Behandlungsansatz zur Trachealkanülenentwöhung und Dekanülierung vorgestellt, der auf der Grundlage der relevanten Forschungsliteratur und klinischen Beobachtungen entwickelt wurde. Des Weiteren wird erstmals eine systematische Evaluation eines multidisziplinären Trachealkanülenmangements vorgenommen und es werden explorative Daten zum Rehabilitationsverlauf dargestellt. In einem retrospektiven Vergleich wurden hierzu die Dekanülierungs- und Komplikationsraten sowie die Dauer der Trachealkanülenentwöhnung zweier Patientengruppen gegenübergestellt, die vor bzw. nach Einführung des beschriebenen multidisziplinären Trachealkanülenmanagements im REHAB Basel, Schweiz, behandelt wurden. Der rehabilitative Verlauf der multidisziplinär behandelten Gruppe wurde mittels der Messinstrumente FIM (Functional Independence Measure) und EFA (Early Functional Abilities) untersucht. Der Vergleich der Dekanülierungs- und Komplikationsraten ergab eine vergleichbare Effektivität der beiden Behandlungsansätze. Darüber hinaus zeigte sich eine signifikante Verkürzung der Kanülenentwöhnungsphase bei Anwendung des multidisziplinären Vorgehens, so dass dieses als effizenter zu beurteilen ist. Die Verlaufsanalyse der multidisziplinär behandelten Patienten ergab erst nach der Dekanülierung einen signifikanten Zuwachs der funktionellen Selbständigkeit in Alltagsaktivitäten. Bei der Mehrzahl der Patienten konnte ein vollständiger oraler Kostaufbau nach der Dekanülierung erreicht werden. N2 - In neurological rehabilitation there is a growing need for information about treatment of tracheotomized dysphagic individuals and treatment methods have to be evaluated objectively. This dissertation presents a multidisciplinary approach for the treatment of tracheotomized dysphagic patients that was developed based on research findings and clinical experiences. Furthermore it presents a first approach to a systematic evaluation of a multidisciplinary treatment protocol and explorative data about the rehabilitative progress in this patient group. In a retrospective analysis mean cannulation times and the success rate of decannulation from patients were compared before and after introduction of the multidisciplinary procedure in a rehabilitation centre, REHAB Basel, Switzerland. Furthermore, the rehabilitation progress was analyzed by means of the assessment tools ‘Functional Independence Measure (FIM)’ and ‘Early Functional Abilities (EFA)’. Decannulation rates and success of decannulation were comparable in both groups of patients. With regard to mean cannulation times, however, a significant reduction was found in the group who underwent multidisciplinary treatment. This indicates a higher efficiency of the multidisciplinary approach, whereas, with regard to effectiveness, the two approaches seem to be comparable. After decannulation the patients of the multidisciplinary group showed clear functional improvements in performing activities of daily living. Most of these patients were able to return to full oral nutrition after decannulation. The multidisciplinary approach was found to be more efficient than the former intradisciplinary protocol as it led to a safe but faster decannulation of tracheotomized dysphagic patients. The explorative data concerning rehabilitation progress in these patients supports the importance of the development of evidence-based treatment protocols that lead to a fast and safe decannulation. This can be considered the basis for further significant improvement of the functional independence of the tracheotomized dysphagic patient. KW - Dysphagie KW - Tracheotomie KW - Trachealkanülenmanagement KW - Interdisziplinäre Behandlung KW - Dysphagia KW - tracheostomy KW - decannulation KW - multidisciplinary approach Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-20164 SN - 978-3-940793-55-3 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hummel, Katja A1 - Frank, Ulrike T1 - Die Schluckfrequenz bei Gesunden in Seiten- vs. Rückenlage JF - Spektrum Patholinguistik Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-47077 SN - 1866-9085 SN - 1866-9433 VL - 3 SP - 187 EP - 190 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Drygala, Frank A1 - Werner, Ulrike A1 - Zoller, Hinrich T1 - Diet composition of the invasive raccoon dog (Nyctereutes procyonoides) and the native red fox (Vulpes vulpes) in north-east Germany JF - Hystrix : the Italian journal of mammalogy N2 - Invasive alien species pose a great threat to the integrity of natural communities by competition with and predation on native species. In Germany the invasive raccoon dog (Nyctereutes procyonoides) and the native red fox (Vulpes vulpes) occupy a similar ecological niche. Therefore, the aim of our study was to discover the extent of exploitative diet competition between these two generalist carnivores. Carcasses of red foxes (n=256) and raccoon dogs (n=253) were collected throughout Mecklenburg Western-Pomerania (north-east Germany) and stomachs contains were analysed. Frequency of occurrence and biomass share indicate that both canids are omnivorous and pursue opportunistic feeding strategies. Small mammals and edible plant material were the most important food resources for red foxes and raccoon dogs. Nonetheless, interspecies differences were recorded for edible plant material, small mammals and insects. While red foxes mostly feed on voles, raccoon dogs consumed mice and shrews as often as voles. Only raccoon dogs preyed on amphibians. There were no differences in carrion consumption, both species scavenged on wild boar and we found clear competition for carrion year-round. Moreover, there was evidence that two red foxes foraged on raccoon dogs and vice versa. The mean annual interspecies diet overlap index was relatively high. The diets determined for raccoon dogs and red foxes were quite similar and a similar food niche breadth was recorded. However, only minor competition is assumed to take place since differences in feeding habits do exist. KW - Nyctereutes procyonoides KW - Vulpes vulpes KW - invasive species KW - diet competition KW - feeding strategies Y1 - 2013 U6 - https://doi.org/10.4404/hystrix.-24.2-8867 SN - 0394-1914 SN - 1825-5272 VL - 24 IS - 2 SP - 190 EP - 194 PB - Associazione Teriologica Romana CY - Roma ER - TY - JOUR A1 - Schneider, Kathleen A1 - Kutz, Anne A1 - Kaps, Hella A1 - Frank, Ulrike T1 - Dysarthria Impact Profile – D BT - Anwendbarkeit des Fragebogens und Selbsteinschätzung der Dysarthrie von ParkinsonpatientInnen im Bereich der Aktivität und Partizipation JF - Spektrum Patholinguistik Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469645 SN - 978-3-86956-479-1 SN - 1866-9085 SN - 1866-9433 IS - 12 SP - 241 EP - 246 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Frank, Ulrike A1 - Radtke, Julia A1 - Nienstedt, Julie Cläre A1 - Pötter-Nerger, Monika A1 - Schönwald, Beate A1 - Buhmann, Carsten A1 - Gerloff, Christian A1 - Niessen, Almut A1 - Flügel, Till A1 - Koseki, Jana-Christiane A1 - Pflug, Christina T1 - Dysphagia screening in Parkinson's Disease BT - a diagnostic accuracy cross-sectional study investigating the applicability of the Gugging Swallowing Screen (GUSS) JF - Neurogastroenterology and motility N2 - Background Simple water-swallowing screening tools are not predictive of aspiration and dysphagia in patients with Parkinson's Disease (PD). We investigated the diagnostic accuracy of a multi-texture screening tool, the Gugging Swallowing Screen (GUSS) to identify aspiration and dysphagia/penetration in PD patients compared to flexible endoscopic evaluation of swallowing (FEES). Methods Swallowing function was evaluated in 51 PD participants in clinical 'on-medication' state with the GUSS and a FEES examination according to standardized protocols. Inter-rater reliability and convergent validity were determined and GUSS- and FEES-based diet recommendations were compared. Key Results Inter-rater reliability of GUSS ratings was high (r(s) = 0.8; p < 0.001). Aspiration was identified by the GUSS with a sensitivity of 50%, and specificity of 51.35% (PPV 28%, NPV 73%, LR+ 1.03, LR- 0.97), dysphagia/penetration was identified with 72.97% sensitivity and 35.71% specificity (PPV 75%, NPV 33.33%, LR+ 1.14, LR- 0.76). Agreement between GUSS- and FEES-based diet recommendations was low (r(s) = 0.12, p = 0.42) with consistent NPO (Nil per Os) allocation by GUSS and FEES in only one participant. Conclusions and Inferences The multi-texture screening tool GUSS in its current form, although applicable with good inter-rater reliability, does not detect aspiration in PD patients with acceptable accuracy. Modifications of the GUSS parameters "coughing," "voice change" and "delayed swallowing" might enhance validity. The GUSS' diet recommendations overestimate the need for oral intake restriction in PD patients and should be verified by instrumental swallowing examination. KW - aspiration KW - dysphagia KW - FEES KW - Gugging Swallowing Screen KW - Parkinson' s disease Y1 - 2021 U6 - https://doi.org/10.1111/nmo.14034 SN - 1350-1925 SN - 1365-2982 VL - 33 IS - 5 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Frank, Ulrike A1 - Radtke, Julia A1 - Nienstedt, Julie Cläre A1 - Pötter-Nerger, Monika A1 - Schönwald, Beate A1 - Buhmann, Carsten A1 - Gerloff, Christian A1 - Niessen, Almut A1 - Flügel, Till A1 - Koseki, Jana-Christiane A1 - Pflug, Christina T1 - Dysphagia screening in Parkinson's Disease BT - a diagnostic accuracy cross-sectional study investigating the applicability of the Gugging Swallowing Screen (GUSS) T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background Simple water-swallowing screening tools are not predictive of aspiration and dysphagia in patients with Parkinson's Disease (PD). We investigated the diagnostic accuracy of a multi-texture screening tool, the Gugging Swallowing Screen (GUSS) to identify aspiration and dysphagia/penetration in PD patients compared to flexible endoscopic evaluation of swallowing (FEES). Methods Swallowing function was evaluated in 51 PD participants in clinical 'on-medication' state with the GUSS and a FEES examination according to standardized protocols. Inter-rater reliability and convergent validity were determined and GUSS- and FEES-based diet recommendations were compared. Key Results Inter-rater reliability of GUSS ratings was high (r(s) = 0.8; p < 0.001). Aspiration was identified by the GUSS with a sensitivity of 50%, and specificity of 51.35% (PPV 28%, NPV 73%, LR+ 1.03, LR- 0.97), dysphagia/penetration was identified with 72.97% sensitivity and 35.71% specificity (PPV 75%, NPV 33.33%, LR+ 1.14, LR- 0.76). Agreement between GUSS- and FEES-based diet recommendations was low (r(s) = 0.12, p = 0.42) with consistent NPO (Nil per Os) allocation by GUSS and FEES in only one participant. Conclusions and Inferences The multi-texture screening tool GUSS in its current form, although applicable with good inter-rater reliability, does not detect aspiration in PD patients with acceptable accuracy. Modifications of the GUSS parameters "coughing," "voice change" and "delayed swallowing" might enhance validity. The GUSS' diet recommendations overestimate the need for oral intake restriction in PD patients and should be verified by instrumental swallowing examination. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 854 KW - aspiration KW - dysphagia KW - FEES KW - Gugging Swallowing Screen KW - Parkinson' s disease Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-569625 SN - 1866-8364 IS - 5 ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich T1 - Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation JF - Pneumologie : Zeitschrift für Pneumologie und Beatmungsmedizin N2 - Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients. Y1 - 2015 U6 - https://doi.org/10.1055/s-0034-1392359 SN - 0934-8387 SN - 1438-8790 VL - 69 IS - 7 SP - 394 EP - 399 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Jäckel, Annemarie A1 - Frank, Ulrike T1 - Effekte des Mendelsohn Manövers auf die Atem-Schluck-Koordination : eine Untersuchung der intra- individuellen Variation bei gesunden Erwachsenen Y1 - 2012 ER - TY - GEN A1 - Jäckel, Annemarie A1 - Frank, Ulrike T1 - Effekte des Mendelsohn Manövers auf die Atem-Schluck-Koordination : eine Untersuchung der intra-individuellen Variation bei gesunden Erwachsenen N2 - 1 Einleitung 2 Fragestellungen 3 Methode 4 Ergebnisse und Diskussion 5 Literatur KW - Patholinguistik KW - Sprachtherapie KW - Dysphagie KW - Schluckstörung KW - Schlucktherapie KW - patholinguistics KW - speech/language therapy KW - dysphagia KW - swallowing disorders KW - dysphagia therapy Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62491 ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich T1 - Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79873 SP - 235 EP - 237 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Vogel, Annemarie A1 - Claus, Inga A1 - Ahring, Sigrid A1 - Gruber, Doreen A1 - Haghikia, Aiden A1 - Frank, Ulrike A1 - Dziewas, Rainer A1 - Ebersbach, Georg A1 - Gandor, Florin A1 - Warnecke, Tobias T1 - Endoscopic characteristics of dysphagia in multiple system atrophy JF - Movement disorders : official journal of the Movement Disorder Society N2 - Background Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. Objective This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. Methods Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings. Results Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4%, piecemeal deglutition, 75.4%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9%; penetration/aspiration, 28.1%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8%, P < 0.001; piecemeal deglutition, 1.8%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85%, specificity 100%). Conclusions In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia. KW - multiple system atrophy KW - dysphagia KW - FEES KW - Swallowing Disturbance Questionnaire KW - SDQ Y1 - 2022 U6 - https://doi.org/10.1002/mds.28854 SN - 0885-3185 SN - 1531-8257 VL - 37 IS - 3 SP - 535 EP - 544 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Leitner, Ulrike A1 - Baron, Frank A1 - Clark, Rex A1 - Doherr, Detlev A1 - Griep, Wolfgang A1 - Schnöpf, Markus ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - HiN : Alexander von Humboldt im Netz = Humboldt Digital Library N2 - - Ulrike Leitner: Einleitung - Frank Baron: From Alexander von Humboldt to Frederic Edwin Church: Voyages of Scientific Exploration and Artistic Creativity - Rex Clark: Alexander von Humboldt‘s Images of Landscape and the ‚Chaos of the Poets - Detlev Doherr: The Humboldt Digital Library: Exploring Innovative Structures - Wolfgang Griep: Die Bedeutung der Umkreisquellen für Alexander von Humboldts südamerikanische Reise - Ulrike Leitner: Vielschichtigkeit und Komplexität im Reisewerk Alexander von Humboldts – Bibliographischer Hintergrund - Markus Schnoepf: El Proyecto Humboldt: Una biblioteca digital para las expediciones científicas a las Islas Canarias T3 - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies - VI.2005, 10 KW - bildende Kunst KW - Frederic Edwin Church KW - Humboldt als Vorbild KW - Gottfried August Bürger KW - Italienische Reise KW - Johann Wolfgang von Goethe KW - Münchhausen KW - Elektronische Edition KW - Google KW - Humboldt Digital Library KW - Pflanzengeographie KW - Volltext KW - Orinoco KW - Relation historique KW - Umkreisquellen KW - 1799-1804 KW - Bibliographie KW - Multilingualität KW - Netzwerke des Wissens KW - Ottmar Ette KW - 1700-1900 KW - Digital Library KW - Islas Canarias KW - Proyecto Humboldt Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-35175 SN - 1617-5239 SN - 2568-3543 N1 - Mit freundlicher Unterstützung von der Stiftung Deutsch-Amerikanisches Konzil – German-American Academic Council Foundation (TRANSCOOP) – a program supporting Transatlantic research among German, U. S., and/or Canadian Scholars in the humanities, social sciences, economic, and law. VL - VI IS - 10 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Ette, Ottmar A1 - Knobloch, Eberhard A1 - Schwarz, Oliver A1 - Werner, Petra A1 - Suckow, Christian A1 - Jobst, Anne A1 - Schmuck, Thomas A1 - Ringmacher, Manfred A1 - Tintemann, Ute A1 - Leitner, Ulrike A1 - Holl, Frank A1 - Panwitz, Sebastian A1 - Péaud, Laura A1 - Holtz, Bärbel A1 - Folkerts, Menso A1 - Päßler, Ulrich A1 - Roba, Bill ED - Ette, Ottmar ED - Knobloch, Eberhard T1 - HiN : Alexander von Humboldt im Netz = Ingo Schwarz zum 65. Geburtstag T2 - HIN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - Inhalt: Alexander von Humboldt-Forschungsstelle: Ingo Schwarz zum 65. Geburtstag Ottmar Ette: Findung und Erfindung einer Leserschaft. Neuere Editionsprojekte zu Alexander von Humboldt als Grundlage und Herausforderung künftigen Forschens Eberhard Knobloch: Alexandre de Humboldt et le Marquis de Laplace Oliver Schwarz: Alexander von Humboldt als astronomischer Arbeiter, Diskussionspartner und Ideengeber Petra Werner: Innenwelten und bleiche Gärten. Alexander von Humboldt untertage und in der Caripe-Höhle Christian Suckow: Alexander von Humboldt in Ust’-Kamenogorsk Anne Jobst: Neue Briefe Christian Gottfried Ehrenbergs an Alexander von Humboldt Thomas Schmuck: Humboldt, Baer und die Evolution Manfred Ringmacher: Zwei Briefe auf Guaraní in Alexander von Humboldts Handschrift Ute Tintemann: Julius Klaproths Mithridates-Projekt, Alexander von Humboldt und das Verlagshaus Cotta Ulrike Leitner: „Ja! Wenn Berlin Bonn wäre!“ Friedrich Rückerts Berufung nach Berlin Frank Holl: „Zur Freiheit bestimmt“ – Alexander von Humboldts Blick auf die Kulturen der Welt Sebastian Panwitz: Das Humboldt-Mendelssohn-Haus Jägerstraße 22. Ein Quellenfund Laura Péaud: Du Mexique à l‘Oural : l‘expertise humboldtienne au service du politique Bärbel Holtz: „Cicerone“ des Königs? Alexander von Humboldt und Friedrich Wilhelm III. Menso Folkerts: Ein unerwartetes Zusammentreffen in Sanssouci. Alexander von Humboldt und Karl Ludwig Hencke an der Tafel Friedrich Wilhelms IV. Ulrich Päßler: Preußens Mann in Washington. Fünf Briefe Friedrich von Gerolts an Alexander von Humboldt (1858/1859) Bill Roba: German-Iowan Strategies in Celebrating the Centennial of Alexander von Humboldt’s Birth Regina Mikosch: Ingo Schwarz‘ Veröffentlichungen zur Alexander von Humboldt Über die Autoren T3 - HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies - XV.2014, 29 KW - Humboldt KW - Alexander von Humboldt KW - Humboldt-Forschung KW - Universität Potsdam KW - BBAW KW - Brief KW - Briefwechsel KW - Editionsprojekte KW - Reisemanuskripte KW - Reisetagebücher KW - amerikanische Reisetagebücher KW - Marquis de Laplace KW - Laplace KW - Astronomie KW - Caripe KW - untertage KW - Höhlenforschung KW - Ust'-Kamenogorsk KW - Christian Gottfried Ehrenberg KW - Baer KW - Evolution KW - Guaraní KW - Julius Klaproth KW - Mithriades KW - Cotta KW - Bonn KW - Berlin KW - Friedrich Rückert KW - Kulturen der Welt KW - Freiheit KW - Sklaverei KW - Abolitionismus KW - Mendelssohn KW - Jägerstraße 22 KW - Mexiko KW - Mexico KW - Neu-Spanien KW - Nouvelle Espagne KW - Oural KW - Ural KW - Politik KW - Friedrich Wilhelm III. KW - Preußen KW - Sanssouci KW - Karl Ludwig Hencke KW - Friedrich Wilhelm IV. KW - Washington D.C. KW - Friedrich von Gerolt KW - Iowa KW - Hundertjahr-Feier KW - Gedenkfeier KW - US-Rezeption KW - Ingo Schwarz Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-85033 SN - 1617-5239 SN - 2568-3543 VL - XV IS - 29 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Engemaier, Eva A1 - Koch, Sina A1 - Böer, Ulrike A1 - Püschel, Gerhard Paul T1 - Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor N2 - Prostanoid receptors belong to the class of heptahelical plasma membrane receptors. For the five prostanoids, eight receptor subtypes have been identified. They display an overall sequence similarity of roughly 30%. Based on sequence comparison, single amino acids in different subtypes of different species have previously been identified by site-directed mutagenesis or in hybrid receptors that appear to be essential for ligand binding or G-protein coupling. Based on this information, a series of mutants of the human FP receptor was generated and characterized in ligand- binding and second-messenger-formation studies. It was found that mutation of His-81 to Ala in transmembrane domain 2 and of Arg-291 to Leu in transmembrane domain 7, which are putative interaction partners for the prostanoid's carboxyl group, abolished ligand binding. Mutants in which Ser-263 in transmembrane domain 6 or Asp-300 in transmembrane domain 7 had been replaced by Ala or Gln, respectively, no longer discriminated between prostaglandins PGF(2alpha) and PGD(2). Thus distortion of the topology of transmembrane domains 6 and 7 appears to interfere with the cyclopentane ring selectivity of the receptor. PGF(2alpha)-induced inositol formation was strongly reduced in the mutant Asp-300Gln, inferring a role for this residue in agonist-induced G-protein activation. Y1 - 2003 UR - http://www.biochemj.org/bj/371/0443/bj3710443.htm ER - TY - JOUR A1 - Frank, Ulrike A1 - van den Engel-Hoek, Lenie A1 - Nogueira, Dalia A1 - Schindler, Antonio A1 - Adams, Sasha A1 - Curry, Morgan A1 - Huckabee, Maggie-Lee T1 - International standardisation of the test of masticating and swallowing solids in children JF - Journal of oral rehabilitation N2 - The Test of Masticating and Swallowing Solids (TOMASS) is a validated assessment tool measuring the efficiency of solid bolus intake by four quantitative parameters: discrete bites, masticatory cycles, swallows and time to ingest a single cracker. A normative database for adults (20-80+ years) has previously been established. The objective of this study was to investigate the applicability and reliability of the TOMASS in children and adolescents (TOMASS-C) and to establish the normative database for this younger population. We collected data from 638 participants (male: 311, female: 327) in five age groups (4-18 years) with five different but very similar test crackers in four countries. Significant effects of bolus type (cracker), age group and gender on the TOMASS parameters were identified, requiring stratification of the TOMASS-C database by these variables. Intra-rater reliability was excellent (ICC > 0.94) for all parameters; inter-rater reliability was moderate for "number of swallows" (ICC = 0.54), good for "bites" (ICC = 0.78) and "time" (ICC = 0.82), and excellent for "masticatory cycles" (ICC = 0.96). The "Test of Masticating and Swallowing Solids in Children (TOMASS-C)" was identified to be a reliable diagnostic tool for the comprehensive measurement of discrete oral stage components of solid bolus ingestion, standardised by a large normative database that covers age groups from preschoolers to young adults. While differences between gender groups were less pronounced than in the adult population, previous results relating to changes in masticatory and swallowing as a function of age are confirmed by our data. KW - mastication KW - normative data KW - reliability KW - solid bolus KW - swallowing Y1 - 2018 U6 - https://doi.org/10.1111/joor.12728 SN - 0305-182X SN - 1365-2842 VL - 46 IS - 2 SP - 161 EP - 169 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Müller, Nina A1 - Beer, Carola de A1 - Frank, Ulrike T1 - Ist die therapeutische Mundpflege bei Dysphagiepatient*innen verschwendete Zeit? BT - ein narrativer Review zu Effekten der Mundpflege auf die Pneumoniehäufigkeit und Ableitung einer Handlungsempfehlung BT - a narrative review on the effects of oral care on pneumonia risk and guidelines for an effective and structured approach JF - Sprache, Stimme, Gehör : Zeitschrift für Kommunikationsstörungen N2 - Aspirationspneumonien sind eine häufige Todesursache bei Dysphagiepatient*innen. In diesem Beitrag wird durch die Evaluation relevanter Studien die Frage untersucht, ob die therapeutische Mundpflege bei Dysphagiepatient*innen zur Verringerung des Pneumonierisikos beitragen kann. Zudem wird auf dieser Grundlage eine Handlungsempfehlung für die Umsetzung der Mundpflege entwickelt. Die ausgewählten Studien zeigen, dass die Mundpflege einen positiven Effekt auf das Pneumonie-Risiko von Dysphagiepatient*innen hat. Sie sollte auf den Grundsätzen Einfachheit, Sicherheit, Arbeitskräfteentlastung, Wirksamkeit, Universalität, Wirtschaftlichkeit und vollständige Mundpflege aller Teile der Mundhöhle beruhen und nimmt weniger als fünf Minuten täglich ein. Sie bereitet durch die taktile Stimulation auf die anschließende Dysphagie-Therapie vor und ist somit sinnvoll investierte Therapiezeit. N2 - Aspiration pneumonia is a common cause of death in dysphagia patients. In this review, we investigate whether a structured oral care approach can help to reduce pneumonia risk in dysphagic patients. In addition, guidelines for the implementation of oral care on the basis of the analyzed studies are presented. Oral care has positive effects on the risk of pneumonia in dysphagia patients. Oral care should be based on the principles of simplicity, safety, efficiency and effectiveness, universality and economy and it should include all parts of the oral cavity. Effective oral care takes less than five minutes a day. The tactile stimulation prepares the patient for dysphagia therapy and can be considered wisely-invested time. T2 - Is oral care for dysphagic patients wasted time? KW - oral care KW - dysphagia KW - pneumonia KW - Therapeutische Mundpflege KW - Dysphagie KW - Pneumonie Y1 - 2022 U6 - https://doi.org/10.1055/a-1714-1587 SN - 0342-0477 SN - 1439-1260 VL - 46 IS - 03 SP - 150 EP - 155 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Opitz, Stephan A1 - Wünnemann, Bernd A1 - Aichner, Bernhard A1 - Dietze, Elisabeth A1 - Hartmann, Kai A1 - Herzschuh, Ulrike A1 - IJmker, Janneke A1 - Lehmkuhl, Frank A1 - Li, Shijie A1 - Mischke, Steffen A1 - Plotzki, Anna A1 - Stauch, Georg A1 - Diekmann, Bernhard T1 - Late Glacial and Holocene development of Lake Donggi Cona, north-eastern Tibetan Plateau, inferred from sedimentological analysis JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - Sediments of Lake Donggi Cona on the northeastern Tibetan Plateau were studied to infer changes in the lacustrine depositional environment, related to climatic and non-climatic changes during the last 19 kyr. The lake today fills a 30x8 km big and 95 m deep tectonic basin, associated with the Kunlun Fault. The study was conducted on a sediment-core transect through the lake basin, in order to gain a complete picture of spatio-temporal environmental change. The recovered sediments are partly finely laminated and are composed of calcareous muds with variable amounts of carbonate micrite, organic matter, detrital silt and clay. On the basis of sedimentological, geochemical, and mineralogical data up to five lithological units (LU) can be distinguished that document distinct stages in the development of the lake system. The onset of the lowermost LU with lacustrine muds above basal sands indicates that lake level was at least 39 m below the present level and started to rise after 19 ka, possibly in response to regional deglaciation. At this time, the lacustrine environment was characterized by detrital sediment influx and the deposition of siliciclastic sediment. In two sediment cores, upward grain-size coarsening documents a lake-level fall after 13 cal ka BP, possibly associated with the late-glacial Younger Dryas stadial. From 11.5 to 4.3 cal ka BP, grain-size fining in sediment cores from the profundal coring sites and the onset of lacustrine deposition at a litoral core site (2 m water depth) in a recent marginal bay of Donggi Cona document lake-level rise during the early to mid-Holocene to at least modern level. In addition, high biological productivity and pronounced precipitation of carbonate micrites are consistent with warm and moist climate conditions related to an enhanced influence of summer monsoon. At 4.3 cal ka BP the lake system shifted from an aragonite- to a calcite-dominated system, indicating a change towards a fully open hydrological lake system. The younger clay-rich sediments are moreover non-laminated and lack any diagenetic sulphides, pointing to fully ventilated conditions, and the prevailing absence of lake stratification. This turning point in lake history could imply either a threshold response to insolation-forced climate cooling or a response to a non-climatic trigger, such as an erosional event or a tectonic pulse that induced a strong earthquake, which is difficult to decide from our data base. KW - China KW - Monsoon KW - Paleolimnology KW - Multi-site study KW - Aragonite KW - XRF KW - XRD KW - Sedimentology Y1 - 2012 U6 - https://doi.org/10.1016/j.palaeo.2012.04.013 SN - 0031-0182 VL - 337 IS - 23 SP - 159 EP - 176 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schirrmeister, Lutz A1 - Meyer, Hanno A1 - Andreev, Andrei A1 - Wetterich, Sebastian A1 - Kienast, Frank A1 - Bobrov, Anatoly A1 - Fuchs, Margret A1 - Sierralta, Melanie A1 - Herzschuh, Ulrike T1 - Late Quaternary paleoenvironmental records from the Chatanika River valley near Fairbanks (Alaska) JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Perennially-frozen deposits are considered as excellent paleoenvironmental archives similar to lacustrine, deep marine, and glacier records because of the long-term and good preservation of fossil records under stable permafrost conditions. A permafrost tunnel in the Vault Creek Valley (Chatanika River Valley, near Fairbanks) exposes a sequence of frozen deposits and ground ice that provides a comprehensive set of proxies to reconstruct the late Quaternary environmental history of Interior Alaska. The multi-proxy approach includes different dating techniques (radiocarbon-accelerator mass spectrometry [AMS C-14], optically stimulated luminescence [OSL], thorium/uranium radioisotope disequilibria [Th-230/U]), as well as methods of sedimentology, paleoecology, hydrochemistry, and stable isotope geochemistry of ground ice. The studied sequence consists of 36-m-thick late Quaternary deposits above schistose bedrock. Main portions of the sequence accumulated during the early and middle Wisconsin periods. The lowermost unit A consists of about 9-m-thick ice-bonded fluvial gravels with sand and peat lenses. A late Sangamon (MIS 5a) age of unit A is assumed. Spruce forest with birch, larch, and some shrubby alder dominated the vegetation. High presence of Sphagnum spores and Cyperaceae pollen points to mires in the Vault Creek Valley. The overlying unit B consists of 10-m-thick alternating fluvial gravels, loess-like silt, and sand layers, penetrated by small ice wedges. OSL dates support a stadial early Wisconsin (MIS 4) age of unit B. Pollen and plant macrofossil data point to spruce forests with some birch interspersed with wetlands around the site. The following unit C is composed of 15-m-thick ice-rich loess-like and organic-rich silt with fossil bones and large ice wedges. Unit C formed during the interstadial mid-Wisconsin (MIS 3) and stadial late Wisconsin (MIS 2) as indicated by radiocarbon ages. Post-depositional slope processes significantly deformed both, ground ice and sediments of unit C. Pollen data show that spruce forests and wetlands dominated the area. The macrofossil remains of Picea, Larix, and Alnus incana ssp. tenuifolia also prove the existence of boreal coniferous forests during the mid-Wisconsin interstadial, which were replaced by treeless tundra-steppe vegetation during the late Wisconsin stadial. Unit C is discordantly overlain by the 2-m-thick late Holocene deposits of unit D. The pollen record of unit D indicates boreal forest vegetation similar to the modern one. The permafrost record from the Vault Creek tunnel reflects more than 90 ka of periglacial landscape dynamics triggered by fluvial and eolian accumulation, and formation of ice-wedge polygons and post depositional deformation by slope processes. The record represents a typical Wisconsin valley-bottom facies in Central Alaska. (C) 2016 Elsevier Ltd. All rights reserved. KW - Permafrost KW - Interior Alaska KW - Loess KW - Cryolithology KW - Geochronology KW - Paleoecology KW - Landscape dynamics Y1 - 2016 U6 - https://doi.org/10.1016/j.quascirev.2016.02.009 SN - 0277-3791 VL - 147 SP - 259 EP - 278 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Mueller-Nordhorn, Jacqueline A1 - Muckelbauer, Rebecca A1 - Englert, Heike A1 - Grittner, Ulrike A1 - Berger, Hendrike A1 - Sonntag, Frank A1 - Völler, Heinz A1 - Prugger, Christof A1 - Wegscheider, Karl A1 - Katus, Hugo A. A1 - Willich, Stefan N. T1 - Longitudinal association between body mass index and health-related quality of life JF - PLoS one N2 - Objective: Health-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity. Design: Secondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy. Methods: HRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time. Results: Of the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (beta [95% CI] per 1 kg/ m(2) : -0.36 [-0.41; -0.30] and -0.05 [-0.11; -0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (-0.18 [-0.27; -0.09]) and only in obese participants (-0.19 [-0.29; -0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population. Conclusion: Increases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pone.0093071 SN - 1932-6203 VL - 9 IS - 3 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Westermann, Antje A1 - Stadie, Nicole A1 - Frank, Ulrike T1 - Messung der Atem-Schluck-Koordination während normalem Schluck und unter Anwendung des Mendelsohn- Manövers Y1 - 2011 ER - TY - JOUR A1 - Westermann, Antje A1 - Stadie, Nicole A1 - Frank, Ulrike T1 - Messung der Atem-Schluck-Koordination während normalem Schluck und unter Anwendung des Mendelsohn-Manövers JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54286 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 143 EP - 147 ER - TY - JOUR A1 - Kästner, Alexander A1 - Schmitz, Claudia A1 - Evert, Urte A1 - Rogger, Philippe A1 - Zielsdorf, Frank A1 - Häcker, Susanne A1 - Bahro, Steffi A1 - Ludwig, Ulrike A1 - Lang, Heinrich A1 - Piltz, Eric A1 - Winter, Martin T1 - Militär und Gesellschaft in der Frühen Neuzeit N2 - Inhalt: AUFSÄTZE Alexander Kästner: „Desertionen in das Jenseits.“ Ansätze und Desiderate einer militärhistorischen Suizidforschung für die Frühe Neuzeit. Claudia Schmitz: Der symbolische und religiöse Gehalt von Gewalt und Krieg im Prozess der inkaischen Staatsentwicklung. PROJEKTE Urte Evert: Die Eisenbraut. Symbolische Funktionen der soldatischen Waffe. Philippe Rogger: Pensionenunruhen 1513-1516. Klientelistische Verflechtung – herrschaftliche Verdichtung – bäuerlicher Widerstand? Frank Zielsdorf: Militärische Erinnerungskulturen zwischen Adelsmentalität und Professionalisierung. Regimentskulturen des preußischen Offizierskorps im 17. und 18. Jahrhundert. Susanne Häcker: Universität und Krieg. Die Auswirkungen des Dreißigjährigen Krieges auf die Universitäten Heidelberg, Tübingen und Freiburg. Steffi Bahro: „Solange der Krieg dauerte, ging alles gut...“ Der abgedankte Soldat im Märchen. TAGUNGSBERICHTE Ulrike Ludwig: Militärrecht in der Frühen Neuzeit, 7. Tagung des AMG (Bayreuth, 4.-7. Oktober 2007). REZENSIONEN Heinrich Lang: William Caferro, John Hawkwood. An English Mercenary in Fourteenth-Century Italy, Baltimore 2006. Eric Piltz: Steven G. Ellis, Raingard Eßer (Hrsg.), Frontiers and the Writing of History, 1500-1850, Hannover-Laatzen 2006. Martin Winter: Michael Epkenhans, Stig Förster, Karen Hagemann (Hrsg.), Militärische Erinnerungskultur. Soldaten im Spiegel von Biographien, Memoiren und Selbstzeugnissen, Paderborn 2006 T3 - Militär und Gesellschaft in der frühen Neuzeit - 11, Heft 2 Y1 - 2007 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16036 SN - 1617-9722 SN - 1861-910X VL - 11 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Dlugaiczyk, Martina A1 - Blastenbrei, Peter A1 - Haas, Hagen A1 - Schmitt, Bernhard A1 - Pühringer, Andrea A1 - Reimer, Torsten A1 - Schreiter, René A1 - Podruczny, Grzegorz A1 - Huntebrinker, Jan Willem A1 - Mehrkens, Heidi A1 - Körber, Esther-Beate A1 - Göse, Frank A1 - Feistauer, Daniela A1 - Muth, Jörg A1 - Busch, Michael A1 - Krebs, Daniel A1 - Luh, Jürgen A1 - Ludwig, Ulrike T1 - Militär und Gesellschaft in der Frühen Neuzeit N2 - Aus dem Inhalt dieser Ausgabe: BEITRÄGE: Martina Dlugaiczyk: Der Waffenstillstand (1609-1621) als Medienereignis Peter Blastenbrei: Literaten und Soldaten (Teil 2) Hagen Haas: "Denn die Bombe, wann sie fällt ..." PROJEKTE: Bernhard Schmitt: "... eine ausgedehnte Gelegenheit zu einer ordentlichen Versorgung und besseren Fortkommen in dem Militärdienste" Andrea Pühringer: Die Darstellung von -Gewalt- im Krieg Torsten Reimer: Armada und Seeschlacht René Schreiter: Das Große Militärwaisenhaus zu Potsdam Grzegorz Podruczny: Preußische Militärarchitektur in Schlesien Jan Willem Huntebrinker: "Von der landsknecht lumphosen" BERICHTE: Heidi Mehrkens: Besatzung, Funktion und Gestalt militärischer Fremdherrschaft Esther-Beate Körber: Bericht über die Tagung der Arbeitsgemeinschaft zur preußischen Geschichte REZENSIONEN: Frank Göse: Dreißigjähriger Krieg und Westfälischer Friede. Forschungen aus westfälischen Adelsarchiven. Vorträge auf dem Kolloquium der Vereinigten Westfälischen Adelsarchive e. V. vom 3.-4. Dezember 1998 in Münster, Selbstverlag der Vereinigten Westfälischen Adelsarchive e. V. 2000 Daniela Feistauer: Karen Hagemann, "Mannlicher Muth und Teutsche Ehre". Nation, Militär und Geschlecht zur Zeit der Antinapo-leonischen Kriege Preußens, Paderborn, München, Wien, Zürich: Ferdinand Schöningh 2002 Jörg Muth: Das Heerwesen in Brandenburg und Preußen von 1640 bis 1806. Bd. 1: Olaf Groehler, Das Heerwesen, 2. Aufl., Berlin: Brandenburgisches Verlaghaus 2001 Michael Busch: Annette Hempel, "Eigentlicher Bericht / So wol auch Abkontra-feytung." Eine Untersuchung der nicht-allegorischen Nach-richtenblätter zu den Schlachten und Belagerungen der schwedischen Armee unter Gustav II Adolf (1628/30-1632), Frankfurt a. M.: Peter Lang Verlag 2000 Daniel Krebs: Michael Zimmer’s Diary. Ein deutsches Tagebuch aus dem Amerikanischen Bürgerkrieg, hrsg. von Jürgen Macha und Andrea Wolf, Frankfurt am Main, Berlin u. a.: Peter Lang Verlag 2001 Jürgen Luh: Michael Hochedlinger, Krise und Wiederherstellung. Öster-reichische Großmachtpolitik zwischen Türkenkrieg und "Zweiter Diplomatischer Revolution" 1787-1791, Berlin Duncker & Humblot 2000 Ulrike Ludwig: Sine ira et studio. Militärhistorische Studien zur Erinnerung an Hans Schmidt, hrsg. von Uta Lindgren, Karl Schnith und Jakob Seibert, Kallmünz/OPF.: Verlag Michael Lassleben 2001 T3 - Militär und Gesellschaft in der frühen Neuzeit - 7, Heft 1 KW - Militär / Geschichte Y1 - 2003 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-28093 SN - 1617-9722 SN - 1861-910X VL - 7 IS - 1 ER - TY - JOUR A1 - Frank, Ulrike A1 - Czepluch, C. A1 - Sticher, H. A1 - Maetzener, F. A1 - Schlaegel, W. A1 - Mäder, M. T1 - Modifiziertes Trachealkanülenmanagement - Platzhaltereinsatz als Option bei erschwerten Dekanülierungen (Pilotprojekt REHAB Basel) JF - Die Rehabilitation : Zeitschrift für Praxis und Forschung in der Rehabilitation N2 - Tracheotomierte Patienten, die sowohl eine Dysphagie als auch respiratorische Defizite aufweisen, haben nach der Dekanülierung häufig Probleme, sich an die translaryngeale Atmung anzupassen. Wir entwickelten ein Dekanülierungsprotokoll für diese Patientengruppe, das optional in unser bestehendes Trachealkanülenmanagement integriert werden kann. Erfüllt ein Patient die hierfür definierten Kriterien, so erfolgt unter laryngoskopischer Kontrolle die Einlage eines Platzhalters, der bis zu 3 Tage in situ verbleibt. Während dieser Probedekanülierungsphase werden die respiratorischen Funktionen und das Speichelmanagement engmaschig überwacht. Auf der Grundlage dieser Evaluation wird dann die Entscheidung für oder gegen eine endgültige Dekanülierung getroffen. Wir stellen den Ablauf, die Kriterienkataloge und die Evaluationsparameter für diese Probedekanülierungsphase vor und illustrieren den Ablauf anhand von 2 Fallbeispielen. KW - decannulation protocol KW - dilatational tracheostomy KW - stoma button KW - respiration KW - dysphagia Y1 - 2013 U6 - https://doi.org/10.1055/s-0032-1306290 SN - 0034-3536 VL - 52 IS - 1 SP - 20 EP - 26 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - Wilzek, Alexa A1 - Frank, Ulrike A1 - van den Engl-Hoek, Lenie A1 - Huckabee, Maggie-Lee T1 - Normdatenerhebung für den »Test of Mastication and Swallowing Solids« für Kinder und Jugendliche im Altersbereich von 4 bis 14 Jahren JF - Spektrum Patholinguistik (Band 10) - Schwerpunktthema: Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-405195 SN - 1866-9085 IS - 10 SP - 123 EP - 129 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Domahs, Frank A1 - Grande, Marion A1 - Domahs, Ulrike T1 - Phonematische Neologismen beim Nachsprechen BT - Evidenz für prosodisches Regelwissen im "segmentalen Chaos" JF - Spektrum Patholinguistik N2 - Auszug: Bei der Beschreibung und Analyse von zentralen Störungen des Nachsprechens stehen - wie bei der Beschreibung und Analyse von Sprachproduktionsstörungen allgemein - Abweichungen auf der lautlichen Ebene zumeist im Vordergrund. In der schwersten Form solcher Störungen können dabei nur noch phonematische Neologismen produziert werden. Doch auch die Definition phonematischer Neologismen als „Wörter, die in der Standardsprache aus lautlichen Gründen … nicht vorkommen“ (Huber et al. 1983) bzw. „Lautkette, … die als solche kein Wort der betreffenden Sprache ist“ (Tesak 2006) beschränkt sich auf segmentale Abweichungen. Prosodische Abweichungen hingegen - insbesondere Abweichungen bei der Wortbetonung - sowie mögliche Wechselwirkungen zwischen segmentalen und prosodischen Eigenschaften von Stimulus und Reaktion werden kaum diskutiert. [...] Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-18952 SN - 1866-9085 SN - 1866-9433 IS - 1 SP - 83 EP - 104 ER - TY - JOUR A1 - Welke, Lisa-Marie A1 - Frank, Ulrike T1 - Pilotfragebogenstudie zur praktischen Umsetzung und Koordination des Trachealkanülen-Managements in Berlin und Brandenburg JF - Spektrum Patholinguistik Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437780 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 SP - 115 EP - 129 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Gaeckle, Maren A1 - Domahs, Frank A1 - Kartmann, Angelika A1 - Tomandl, Bernd A1 - Frank, Ulrike T1 - Predictors of Penetration-Aspiration in Parkinson’s Disease Patients With Dysphagia BT - a retrospective analysis JF - Annals of Otology, Rhinology and Laryngology N2 - Methods: The data of 89 PD patients with dysphagia who underwent routinely conducted videofluoroscopic studies of swallowing (VFSS) were included in this retrospective study. The occurrence of penetration-aspiration was defined as scores >= 3 on the Penetration-Aspiration Scale (PAS). Four commonly reported signs of dysphagia in PD patients were evaluated as possible predictors. Furthermore, the relationships between the occurrence of penetration-aspiration and liquid bolus volume as well as clinical severity of PD (modified Hoehn and Yahr scale) were examined. Results: Logistic regression showed that a delayed initiation of the pharyngeal swallow (odds ratio [OR] = 7.47, P = .008) and a reduced hyolaryngeal excursion (OR = 5.13, P = .012) were predictors of penetration-aspiration. Moreover, there was a strong, positive correlation between increasing liquid bolus volume and penetration-aspiration (gamma = 0.71, P < .001). No correlation was found between severity of PD and penetration-aspiration (gamma = 0.077, P = .783). Conclusion: Results of the present study allow for a better understanding of penetration-aspiration risk in PD patients. They are useful for treatment planning in order to improve safe oral intake and adequate nutrition. KW - pneumonia KW - videofluoroscopy Y1 - 2019 U6 - https://doi.org/10.1177/0003489419841398 SN - 0003-4894 SN - 1943-572X VL - 128 IS - 8 SP - 728 EP - 735 PB - Sage Publ. CY - Thousand Oaks ER - TY - GEN A1 - Embs, Frank A1 - Funhoff, Dirk A1 - Laschewsky, André A1 - Licht, Ulrike A1 - Ohst, Holger A1 - Prass, Werner A1 - Ringsdorf, Helmut A1 - Wegner, Gerhard A1 - Wehrmann, Rolf T1 - Preformed polymers for Langmuir-Blodgett films- molecular concepts N2 - The use of preformed polymers for the preparation of Langmuir-Blodgett (LB) multilayers is reviewed. Principles for polymer self-organization are outlined and the appropriate molecular designs are discussed. Recent developments in the different classes of polymers for LB multilayers are presented, and their outstanding properties highlighted. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 081 KW - Amphiphilic Polymers KW - Rod-like Polymers KW - LCPs KW - Stability of LB Films Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-17196 ER - TY - JOUR A1 - Böer, Ulrike A1 - Neuschäfer-Rube, Frank A1 - Möller, Ulrike A1 - Püschel, Gerhard Paul T1 - Requirement of N-glycosylation of the prostaglandin E2 receptor EP3beta for correct sorting to the plasma membrane but not for correct folding N2 - Eight heptahelical receptors have been characterized for prostaglandin (PG) D(2), PGE(2), PGF(2alpha), prostacyclin and thromboxane A(2). They share a sequence identity of 40%. All of them have potential N-glycosylation sites. The current study analysed the role of the two N-glycosylation sites in the rat EP3beta-subtype PGE(2) receptor for protein folding and sorting. The N-glycosylation consensus sequences were eliminated by site-directed mutagenesis and receptors expressed in HEK-293 cells. Both potential N-glycosylation sites were used. Their joint elimination resulted in the synthesis of a receptor protein with full binding competence, biological activity and no reduction of affinity; however, the half-life of the non-glycosylated receptor was slightly reduced. Ligand binding to intact stably transfected cells and confocal laser microscopic immunocytochemistry showed that the glycosylated receptor was correctly inserted into the plasma membrane to a much larger extent than the non-glycosylated receptor, which tended to accumulate in the perinuclear zone of the endoplasmic reticulum. Inhibition of N-glycosylation with tunicamycin resulted in a similar perinuclear distribution of the wild-type receptor. Therefore, glycosylation of the EP3beta receptor seems not to be necessary for correct folding of the receptor protein but for the efficient transport of the receptor protein to the plasma membrane. This contrasts with a previous finding which described a reduction of the affinity for PGE(2) of the EP3alpha receptor by elimination of the distal glycosylation site when the receptor protein was expressed in insect cells. Y1 - 2000 ER - TY - JOUR A1 - Bykova, Ksenia A1 - Frank, Ulrike T1 - Scale for an Assessment of Risk of Aspiration, oder SARA: Aspirationsscreening für Kinder mit Cerebralparese in Russland JF - Spektrum Patholinguistik (Band 10) - Schwerpunktthema: Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-405160 SN - 1866-9085 IS - 10 SP - 115 EP - 121 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Weiland, Linda A1 - Netzebandt, Jonka A1 - Frank, Ulrike T1 - Schluckstörungen bei HNO-Tumorpatienten BT - Eine Einzelfallstudie zur Dysphagietherapie mithilfe des sEMG-Biofeedback-Verfahrens JF - Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie N2 - 1. Einleitung, 2. Theoretischer Hintergrund, 3. Fragestellung und Hypothesen, 4. Methoden, 5. Ergebnisse, 6. Diskussion, 7. Literatur Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-99115 SN - 1866-9085 SN - 1866-9433 IS - 9 SP - 219 EP - 234 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Krusche, Lisa A1 - Netzebandt, Jonka A1 - Frank, Ulrike T1 - SEE-DT: Screening für die Evaluation sEMG-gestützter Dysphagietherapie BT - Entwicklung und Untersuchung der Retest-Reliabilität JF - Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie N2 - 1. Einleitung, 2. Theoretischer Hintergrund, 3. Aufbau des Screenings, 4. Methoden, 5. Ergebnisse, 6. Diskussion, 7. Ausblick, 8. Literatur Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-99142 SN - 1866-9085 SN - 1866-9433 IS - 9 SP - 259 EP - 269 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Frank, Ulrike T1 - Sehen hilft Lernen: sEMG Biofeedback in der Dysphagietherapie JF - Spektrum Patholinguistik (Band 10) - Schwerpunktthema: Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-405081 SN - 1866-9085 IS - 10 SP - 73 EP - 89 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Loppnow, Anna A1 - Netzebandt, Jonka A1 - Frank, Ulrike A1 - Huckabee, Maggie-Lee T1 - Skill-Training in der Dysphagietherapie BT - Möglichkeiten eines patientenorientierten Vorgehens mittels sEMG-Biofeedback JF - Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie N2 - 1. Einleitung, 2. sEMG-Biofeedback in der Dysphagietherapie, 3. Fragestellung, 4. Methodisches Vorgehen, 5. Ergebnisse, 6. Diskussion, 7. Literatur Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-99139 SN - 1866-9085 SN - 1866-9433 IS - 9 SP - 243 EP - 258 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - CHAP A1 - Frombach, Janna A1 - Rancan, Fiorenza A1 - Fleige, Emanuel A1 - Haag, Rainer A1 - Schumacher, Frank A1 - Kleuser, Burkhard A1 - Yamamoto, Kenji A1 - Rühl, Eckart A1 - Blume-Peytavi, Ulrike A1 - Vogt, Annika T1 - Skin penetration and dexamethasone release from polymer nanoparticles in ex vivo human skin T2 - The journal of investigative dermatology Y1 - 2015 SN - 0022-202X SN - 1523-1747 VL - 135 SP - S52 EP - S52 PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Gervais, Frank A1 - Siedel, Ulrike A1 - Heilmann, Britta A1 - Weithoff, Guntram A1 - Heisig-Gunkel, Gabriele A1 - Nicklisch, Andreas T1 - Small-scale vertical distribution of phytoplankton, nutrients and sulphide below the oxicline of a mesotrophic lake N2 - A characteristic vertical sequence of phytoplankton populations was observed below the metalimnetic oxycline of a stratified, mesotrophic lake. Ceratium spp., Closterium acutum and Aphanizomenon flos- aquae were present in the epilimnion but had distinct population maxima in the microaerobic chemocline. Below these populations, Cryptomonas phaseolus, Planktothrix clathrata, Pseudanabaena catenata and Limnothrix sp. followed each other in the transition zone between the chemocline and the sulphide-containing hypolimnion. The dominating populations of P. clathrata and P. catenata caused a deep chlorophyll maximum. Phytoplankton structure was determined by the vertical gradients of sulphide and light. Compared with the epilimnion, nutrient availability was not fundamentally better below the oxycline but the algae might have benefited from reduced grazing pressure in their habitat. Y1 - 2003 UR - http://plankt.oupjournals.org/cgi/content/full/25/3/273 ER -