TY - JOUR A1 - Klann-Delius, Gisela A1 - Kauschke, Christina A1 - Glück, Christian W. A1 - Schröder, Astrid A1 - Lorenz, Antje A1 - Domahs, Frank A1 - Grande, Marion A1 - Domahs, Ulrike A1 - Frankenberg, Jenny v. A1 - Wahl, Michael A1 - De Kok, Dörte A1 - Stadie, Nicole A1 - Machleb, Franziska A1 - Manz, Katrin A1 - Frank, Ulrike A1 - Sperlich, Kathrin A1 - Vauth, Friederike A1 - Hampel, Pamela A1 - Mäder, Mark A1 - Sticher, Heike A1 - Bethmann, Anja A1 - Fischenich, Andrea A1 - Scheich, Henning A1 - Brechmann, André A1 - Peschke, Claudia A1 - Ziegler, Wolfram A1 - Kappes, Juliane A1 - Baumgärtner, Annette A1 - Sonntag, Kristin A1 - Bartels, Luise A1 - Heide, Judith A1 - Meinunger, André A1 - Burchert, Frank A1 - Bohn, Christiane A1 - Kliegl, Reinhold A1 - Gottal, Stephanie A1 - Berendes, Karin A1 - Grabherr, Britta A1 - Schneeberg, Jennifer A1 - Wittler, Marion A1 - Ptok, Martin A1 - Sallat, Stephan ED - Wahl, Michael ED - Michael, Judith ED - Hanne, Sandra T1 - Spektrum Patholinguistik = Schwerpunktthema: der Erwerb von Lexikon und Semantik: Meilensteine, Störungen und Therapie ; Tagungsband zum 1. Herbsttreffen Patholinguistik, 24. November 2007 N2 - Der vorliegende Tagungsband enthält alle Beiträge des 1. Herbsttreffens Patholinguistik, das am 24.11.2007 an der Universität Potsdam stattgefunden hat. Sowohl die drei Hauptvorträge zum Thema „Der Erwerb von Lexikon und Semantik – Meilensteine, Störungen und Therapie“ als auch die Kurzvorträge promovierter Patholinguisten sind ausführlich dokumentiert. Außerdem enthält der Tagungsband die Abstracts der präsentierten Poster. N2 - These proceedings contain the contributions presented at the “1st Herbsttreffen Patholinguistik” that took place on November 24, 2007 at the University of Potsdam. Three main lectures focused on "The acquisition of lexicon and semantics - milestones, impairments, and intervention". In addition, the proceedings contain short presentations on patholinguistic research and the abstracts of the presented posters. T3 - Spektrum Patholinguistik - 1 KW - Patholinguistik KW - Spracherwerb KW - Sprachtherapie KW - lexikalisch-semantische Störungen KW - Sprachentwicklungsstörung (SES) KW - patholinguistics KW - language acquisition KW - speech and language therapy KW - impairments of lexicon and semantics KW - specific language impairment (SLI) Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-18688 SN - 1869-3822 SN - 1866-9433 IS - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Aichert, Ingrid A1 - Staiger, Anja A1 - Schulte-Mäter, Anne A1 - Becker-Redding, Ulrike A1 - Stahn, Corinna A1 - Peschke, Claudia A1 - Heide, Judith A1 - Ott, Susan A1 - Herrmann, Heike A1 - Völsch, Juliane A1 - Mayer, Jörg A1 - Rohnke, Lucie A1 - Frank, Ulrike A1 - Stadie, Nicole A1 - Jentsch, Nadine A1 - Blech, Anke A1 - Kurtenbach, Stephanie A1 - Thieke, Johanna A1 - Schröder, Astrid A1 - Stahn, Corinna A1 - Hörnig, Robin A1 - Burchert, Frank A1 - De Bleser, Ria A1 - Heister, Julian A1 - Bartels, Luise A1 - Würzner, Kay-Michael A1 - Böhme, Romy A1 - Burmester, Juliane A1 - Krajewski, Melanie A1 - Nager, Wido A1 - Jungehülsing, Gerhard Jan A1 - Wartenburger, Isabell A1 - Jöbges, Michael A1 - Schwilling, Eleonore A1 - Lidzba, Karen A1 - Winkler, Susanne A1 - Konietzko, Andreas A1 - Krägeloh-Mann, Ingeborg A1 - Rilling, Eva A1 - Wilken, Rainer A1 - Wismann, Kathrin A1 - Glandorf, Birte A1 - Hoffmann, Hannah A1 - Hinnenkamp, Christiane A1 - Rohlmann, Insa A1 - Ludewigt, Jacqueline A1 - Bittner, Christian A1 - Orlov, Tatjana A1 - Claus, Katrin A1 - Ehemann, Christine A1 - Winnecken, Andreas A1 - Hummel, Katja A1 - Breitenstein, Sarah ED - Wahl, Michael ED - Stahn, Corinna ED - Hanne, Sandra ED - Fritzsche, Tom T1 - Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen N2 - Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universität Potsdam statt. Der vorliegende Tagungsband enthält die drei Hauptvorträge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen“. Darüber hinaus enthält der Band die Beiträge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpräsentationen. N2 - The 3rd Herbsttreffen Patholinguistik was held on November 21st, 2009 at the University of Potsdam. These proceedings contain the three main lectures of the central topic „From programming to articulation: Apraxia of speech of children and adults “. Additionally this volume contains the contributions of Spektrum Patholinguistik, as well as the abstracts of the poster presentations. T3 - Spektrum Patholinguistik - 3 KW - Patholinguistik KW - Sprechapraxie KW - Sprachtherapie KW - patholinguistics KW - apraxia of speech KW - speech and language therapy Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45470 SN - 978-3-86956-079-3 SN - 1869-3822 SN - 1866-9433 IS - 3 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Aktas, Maren A1 - Succow, Juliane A1 - Giel, Barbara A1 - Dressel, Katharina A1 - Lange, Inga A1 - Hanne, Sandra A1 - Burchert, Frank A1 - Vasishth, Shravan A1 - Schwytay, Jeannine A1 - Breitenstein, Sarah A1 - Fleischhauer, Elisabeth A1 - Baumann, Jeannine A1 - Preisinger, Irmhild A1 - Siegmüller, Julia A1 - Kuschmann, Anja A1 - Ebert, Susanne A1 - Lowit, Anja A1 - Rath, Elisa A1 - Heide, Judith A1 - Lorenz, Antje A1 - Wartenburger, Isabell A1 - Hippeli, Carolin A1 - Rausch, Monika A1 - Würzner, Kay-Michael A1 - Schroeder, Sascha A1 - Czapka, Sophia A1 - Klassert, Annegret A1 - Reuters, Sabine A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich A1 - Peiffers, Sabine A1 - Thonicke, Mady ED - Adelt, Anne ED - Otto, Constanze ED - Fritzsche, Tom ED - Magister, Caroline T1 - Spektrum Patholinguistik = Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder N2 - Das 8. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Besonders behandeln? Sprachtherapie im Rahmen primärer Störungsbilder" fand am 15.11.2014 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die vier Hauptvorträge zum Schwerpunktthema, die vier Kurzvorträge aus dem Spektrum Patholinguisitk sowie die Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eighth Autumn Meeting Patholinguistics ('Herbsttreffen Patholinguistik') with its main topic "Special treatment? Language therapy in the context of primary disorders" took place in Potsdam on November 15 2014. This annual meeting has been organized since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the four keynote talks on the main topic, the four short talks from the series 'Spectrum Patholinguistics', as well as the contributions of the poster session from all areas of speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 8 KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77147 SN - 978-3-86956-335-0 SN - 1869-3822 SN - 1866-9433 IS - 8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Voigt-Zimmermann, Susanne A1 - Stier, Karl-Heinz A1 - Lascheit, Thomas A1 - Kruse, Stephanie A. A1 - Blickensdorff, Maria A1 - Förster, Theresa A1 - Schumacher, Rebecca A1 - Burchert, Frank A1 - Ablinger, Irene A1 - Förster, Christine A1 - Wahl, Michael A1 - Schirmacher, Irene A1 - Ostermann, Frank A1 - Welke, Lisa-Marie A1 - Frank, Ulrike A1 - Zakariás, Lilla A1 - Salis, Christos A1 - Wartenburger, Isabell A1 - Krug, Ragna A1 - Stübner, Hanna A1 - Hoffmann, Sophie A1 - Heide, Judith ED - Fritzsche, Tom ED - Yetim, Özlem ED - Otto, Constanze ED - Adelt, Anne T1 - Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie N2 - Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Hauptvorträge zum Schwerpunktthema sowie Beiträge zu den Kurzvorträgen »Spektrum Patholinguistik« und der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eleventh Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Well tuned: Diagnostics and therapy in dysphonia« took place in Potsdam on November 18 2017. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the keynote talks on the main topic as well as contributions from the short talks in the section »Spectrum Patholinguistics« and from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 11 KW - Patholinguistik KW - Sprachtherapie KW - Stimmtherapie KW - Stimmstörung KW - Dysphonie KW - patholinguistics KW - speech/language therapy KW - voice therapy KW - dysphonia Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-418574 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Corsten, Sabine A1 - Günther, Thomas A1 - Nieslony, Julia A1 - Flöther, Manfred A1 - Rott, Anke A1 - Schöppe, Doreen A1 - Kösterke-Buchardt, Antje A1 - Machleb, Franziska A1 - Purat, Patricia A1 - Euler, Harald A. A1 - Breitenstein, Sarah A1 - Düsterhöft, Stefanie A1 - Posse, Dorothea A1 - Topaj, Nathalie A1 - Golcher, Felix A1 - Gagarina, Natalʹja Vladimirovna A1 - Stegenwallner-Schütz, Maja Henny Katherine A1 - Lassotta, Romy A1 - Ferchland, Lisa A1 - Adani, Flavia A1 - Wotschack, Christiane A1 - Klassert, Annegret A1 - Festman, Julia A1 - Schumacher, Rebecca A1 - Burchert, Frank A1 - Ablinger, Irene A1 - Buttler, Rahel A1 - Frank, Luis A1 - Stadie, Nicole A1 - Weiland, Linda A1 - Netzebandt, Jonka A1 - Frank, Ulrike A1 - Bykova, Ksenia A1 - Loppnow, Anna A1 - Huckabee, Maggie-Lee A1 - Krusche, Lisa ED - Fritzsche, Tom ED - Yetim, Özlem ED - Otto, Constanze ED - Adelt, Anne T1 - Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie T2 - Spektrum Patholinguistik N2 - Das 9. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie" fand am 14.11.2015 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die vier Hauptvorträge zum Schwerpunktthema, die drei Kurzvorträge aus dem Spektrum Patholinguisitk sowie die Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Ninth Autumn Meeting Patholinguistics ('Herbsttreffen Patholinguistik') with its main topic "Lots of sounds: Phonological processing and sound perception in speech/language therapy" took place in Potsdam on November 14 2015. This annual meeting has been organized since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the four keynote talks on the main topic, the three short talks from the series 'Spectrum Patholinguistics', as well as the contributions of the poster session from all areas of speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 9 KW - Patholinguistik KW - Sprachtherapie KW - Phonologische Verarbeitung KW - Lautwahrnehmung KW - Sprachverarbeitung KW - patholinguistics KW - speech/language therapy KW - phonological processing KW - sound perception KW - language processing Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-96653 SN - 978-3-86956-385-5 SN - 1866-9085 SN - 1866-9433 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Oppermann, Martin A1 - Möller, Ulrike A1 - Böer, Ulrike A1 - Püschel, Gerhard Paul T1 - Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid N2 - Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R. Y1 - 1999 SN - 1521-0111 ER - TY - JOUR A1 - Böer, Ulrike A1 - Neuschäfer-Rube, Frank A1 - Möller, Ulrike A1 - Püschel, Gerhard Paul T1 - Requirement of N-glycosylation of the prostaglandin E2 receptor EP3beta for correct sorting to the plasma membrane but not for correct folding N2 - Eight heptahelical receptors have been characterized for prostaglandin (PG) D(2), PGE(2), PGF(2alpha), prostacyclin and thromboxane A(2). They share a sequence identity of 40%. All of them have potential N-glycosylation sites. The current study analysed the role of the two N-glycosylation sites in the rat EP3beta-subtype PGE(2) receptor for protein folding and sorting. The N-glycosylation consensus sequences were eliminated by site-directed mutagenesis and receptors expressed in HEK-293 cells. Both potential N-glycosylation sites were used. Their joint elimination resulted in the synthesis of a receptor protein with full binding competence, biological activity and no reduction of affinity; however, the half-life of the non-glycosylated receptor was slightly reduced. Ligand binding to intact stably transfected cells and confocal laser microscopic immunocytochemistry showed that the glycosylated receptor was correctly inserted into the plasma membrane to a much larger extent than the non-glycosylated receptor, which tended to accumulate in the perinuclear zone of the endoplasmic reticulum. Inhibition of N-glycosylation with tunicamycin resulted in a similar perinuclear distribution of the wild-type receptor. Therefore, glycosylation of the EP3beta receptor seems not to be necessary for correct folding of the receptor protein but for the efficient transport of the receptor protein to the plasma membrane. This contrasts with a previous finding which described a reduction of the affinity for PGE(2) of the EP3alpha receptor by elimination of the distal glycosylation site when the receptor protein was expressed in insect cells. Y1 - 2000 ER - TY - JOUR A1 - Gaeckle, Maren A1 - Domahs, Frank A1 - Kartmann, Angelika A1 - Tomandl, Bernd A1 - Frank, Ulrike T1 - Predictors of Penetration-Aspiration in Parkinson’s Disease Patients With Dysphagia BT - a retrospective analysis JF - Annals of Otology, Rhinology and Laryngology N2 - Methods: The data of 89 PD patients with dysphagia who underwent routinely conducted videofluoroscopic studies of swallowing (VFSS) were included in this retrospective study. The occurrence of penetration-aspiration was defined as scores >= 3 on the Penetration-Aspiration Scale (PAS). Four commonly reported signs of dysphagia in PD patients were evaluated as possible predictors. Furthermore, the relationships between the occurrence of penetration-aspiration and liquid bolus volume as well as clinical severity of PD (modified Hoehn and Yahr scale) were examined. Results: Logistic regression showed that a delayed initiation of the pharyngeal swallow (odds ratio [OR] = 7.47, P = .008) and a reduced hyolaryngeal excursion (OR = 5.13, P = .012) were predictors of penetration-aspiration. Moreover, there was a strong, positive correlation between increasing liquid bolus volume and penetration-aspiration (gamma = 0.71, P < .001). No correlation was found between severity of PD and penetration-aspiration (gamma = 0.077, P = .783). Conclusion: Results of the present study allow for a better understanding of penetration-aspiration risk in PD patients. They are useful for treatment planning in order to improve safe oral intake and adequate nutrition. KW - pneumonia KW - videofluoroscopy Y1 - 2019 U6 - https://doi.org/10.1177/0003489419841398 SN - 0003-4894 SN - 1943-572X VL - 128 IS - 8 SP - 728 EP - 735 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich T1 - Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten JF - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder KW - Patholinguistik KW - Sprachtherapie KW - geistige Behinderung KW - primär progessive Aphasie KW - patholinguistics KW - speech therapy KW - mental deficiency KW - primary progessive aphasia Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79873 SP - 235 EP - 237 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin T1 - COVID-19 BT - neue Herausforderungen in der Dysphagie- und Atemtherapie BT - new challenges in dysphagia and respiratory therapy JF - Der Nervenarzt : Organ der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft für Neurologie N2 - Eine COVID-19-Erkrankung kann zu schweren Krankheitsverläufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschränkungen führen. Schluckstörungen (Dysphagien) können in dieser Patientengruppe durch primäre Schädigungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die häufig längere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID“), sodass die Patienten auch längerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme benötigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivität und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem müssen Auswahl und Durchführungsintensität therapeutischer Maßnahmen an die Kapazitäten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern. N2 - Coronavirus disease 2019 (COVID-19) can lead to severe disease courses with multiple organ involvement, respiratory and neurological functional impairments. Swallowing disorders (dysphagia) in this patient group can result from primary damage to the central and peripheral neuronal swallowing network but also from the frequently prolonged intensive care treatment and mechanical ventilation. Clinical observations indicate persistence of dysphagia in post-acute COVID-19 syndrome (long COVID), so that these patients probably also need long-term interventions for rehabilitation of safe and sufficient oral feeding. Therefore, structured disease-specific monitoring of dysphagia symptoms should be integrated into the treatment of COVID-19 patients and respiratory therapy should be an essential part of dysphagia management to re-establish cough effectiveness and breathing-swallowing coordination. Challenges arise from necessary adjustments to established treatment standards to prevent infections. Furthermore, the selection and intensity of therapeutic measures have to be adapted to the capacities and the specific pathophysiology of COVID-19 and long COVID patients to prevent further functional deterioration. KW - Long COVID KW - Fatigue KW - Post intensive care syndrome (PICS) KW - Laryngeal functions KW - Laryngeale Funktionen KW - Hypoxemia KW - Hypoxämie KW - Long-COVID Y1 - 2021 U6 - https://doi.org/10.1007/s00115-021-01162-5 SN - 0028-2804 SN - 1433-0407 VL - 93 IS - 2 SP - 167 EP - 174 PB - Springer CY - New York ER - TY - JOUR A1 - Schlickewei, Ole A1 - Nienstedt, Julie Cläre A1 - Frank, Ulrike A1 - Fründt, Odette A1 - Pötter-Nerger, Monika A1 - Gerloff, Christian A1 - Buhmann, Carsten A1 - Müller, Frank A1 - Lezius, Susanne A1 - Koseki, Jana-Christiane A1 - Pflug, Christina T1 - The ability of the eating assessment tool‑10 to detect penetration and aspiration in Parkinson’s disease JF - European archives of oto-rhino-laryngology and head & neck N2 - Purpose: Dysphagia is common in patients with Parkinson's disease (PD) and often leads to pneumonia, malnutrition, and reduced quality of life. This study investigates the ability of the Eating Assessment Tool-10 (EAT-10), an established, easy self-administered screening tool, to detect aspiration in PD patients. This study aims to validate the ability of the EAT-10 to detect FEES-proven aspiration in patients with PD. Methods: In a controlled prospective cross-sectional study, a total of 50 PD patients completed the EAT-10 and, subsequently, were examined by Flexible Endoscopic Evaluation of Swallowing (FEES) to determine the swallowing status. The results were rated through the Penetration-Aspiration Scale (PAS) and data were analyzed retrospectively. Results: PAS and EAT-10 did not correlate significantly. Selected items of the EAT-10 could not predict aspiration or residues. 19 (38%) out of 50 patients with either penetration or aspiration were not detected by the EAT-10. The diagnostic accuracy was established at only a sufficient level (AUC 0.65). An optimal cut-off value of >= 6 presented a sensitivity of 58% and specificity of 82%. Conclusions: The EAT-10 is not suited for the detection of penetration and aspiration in PD patients. Therefore, it cannot be used as a screening method in this patient population. There is still a need for a valid, simple, and efficient screening tool to assist physicians in their daily diagnostics and to avoid clinical complications. KW - Parkinson's disease KW - dysphagia KW - questionnaire KW - screening Y1 - 2020 U6 - https://doi.org/10.1007/s00405-020-06377-x SN - 0937-4477 SN - 1434-4726 VL - 278 IS - 5 SP - 1661 EP - 1668 PB - Springer CY - Berlin ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Zimmermann, Heinrich T1 - Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation JF - Pneumologie : Zeitschrift für Pneumologie und Beatmungsmedizin N2 - Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients. Y1 - 2015 U6 - https://doi.org/10.1055/s-0034-1392359 SN - 0934-8387 SN - 1438-8790 VL - 69 IS - 7 SP - 394 EP - 399 PB - Thieme CY - Stuttgart ER - TY - JOUR A1 - van der Valk, Ralf J. P. A1 - Kreiner-Moller, Eskil A1 - Kooijman, Marjolein N. A1 - Guxens, Monica A1 - Stergiakouli, Evangelia A1 - Saaf, Annika A1 - Bradfield, Jonathan P. A1 - Geller, Frank A1 - Hayes, M. Geoffrey A1 - Cousminer, Diana L. A1 - Koerner, Antje A1 - Thiering, Elisabeth A1 - Curtin, John A. A1 - Myhre, Ronny A1 - Huikari, Ville A1 - Joro, Raimo A1 - Kerkhof, Marjan A1 - Warrington, Nicole M. A1 - Pitkanen, Niina A1 - Ntalla, Ioanna A1 - Horikoshi, Momoko A1 - Veijola, Riitta A1 - Freathy, Rachel M. A1 - Teo, Yik-Ying A1 - Barton, Sheila J. A1 - Evans, David M. A1 - Kemp, John P. A1 - St Pourcain, Beate A1 - Ring, Susan M. A1 - Smith, George Davey A1 - Bergstrom, Anna A1 - Kull, Inger A1 - Hakonarson, Hakon A1 - Mentch, Frank D. A1 - Bisgaard, Hans A1 - Chawes, Bo Lund Krogsgaard A1 - Stokholm, Jakob A1 - Waage, Johannes A1 - Eriksen, Patrick A1 - Sevelsted, Astrid A1 - Melbye, Mads A1 - van Duijn, Cornelia M. A1 - Medina-Gomez, Carolina A1 - Hofman, Albert A1 - de Jongste, Johan C. A1 - Taal, H. Rob A1 - Uitterlinden, Andre G. A1 - Armstrong, Loren L. A1 - Eriksson, Johan A1 - Palotie, Aarno A1 - Bustamante, Mariona A1 - Estivill, Xavier A1 - Gonzalez, Juan R. A1 - Llop, Sabrina A1 - Kiess, Wieland A1 - Mahajan, Anubha A1 - Flexeder, Claudia A1 - Tiesler, Carla M. T. A1 - Murray, Clare S. A1 - Simpson, Angela A1 - Magnus, Per A1 - Sengpiel, Verena A1 - Hartikainen, Anna-Liisa A1 - Keinanen-Kiukaanniemi, Sirkka A1 - Lewin, Alexandra A1 - Alves, Alexessander Da Silva Couto A1 - Blakemore, Alexandra I. F. A1 - Buxton, Jessica L. A1 - Kaakinen, Marika A1 - Rodriguez, Alina A1 - Sebert, Sylvain A1 - Vaarasmaki, Marja A1 - Lakka, Timo A1 - Lindi, Virpi A1 - Gehring, Ulrike A1 - Postma, Dirkje S. A1 - Ang, Wei A1 - Newnham, John P. A1 - Lyytikainen, Leo-Pekka A1 - Pahkala, Katja A1 - Raitakari, Olli T. A1 - Panoutsopoulou, Kalliope A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Groen-Blokhuis, Maria A1 - Ilonen, Jorma A1 - Franke, Lude A1 - Hirschhorn, Joel N. A1 - Pers, Tune H. A1 - Liang, Liming A1 - Huang, Jinyan A1 - Hocher, Berthold A1 - Knip, Mikael A1 - Saw, Seang-Mei A1 - Holloway, John W. A1 - Melen, Erik A1 - Grant, Struan F. A. A1 - Feenstra, Bjarke A1 - Lowe, William L. A1 - Widen, Elisabeth A1 - Sergeyev, Elena A1 - Grallert, Harald A1 - Custovic, Adnan A1 - Jacobsson, Bo A1 - Jarvelin, Marjo-Riitta A1 - Atalay, Mustafa A1 - Koppelman, Gerard H. A1 - Pennell, Craig E. A1 - Niinikoski, Harri A1 - Dedoussis, George V. A1 - Mccarthy, Mark I. A1 - Frayling, Timothy M. A1 - Sunyer, Jordi A1 - Timpson, Nicholas J. A1 - Rivadeneira, Fernando A1 - Bonnelykke, Klaus A1 - Jaddoe, Vincent W. V. T1 - A novel common variant in DCST2 is associated with length in early life and height in adulthood JF - Human molecular genetics N2 - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height. Y1 - 2015 U6 - https://doi.org/10.1093/hmg/ddu510 SN - 0964-6906 SN - 1460-2083 VL - 24 IS - 4 SP - 1155 EP - 1168 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin T1 - Teamwork is it! BT - Intensivmedizin geht nicht allein JF - Spektrum Patholinguistik 15 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-572134 SN - 978-3-86956-542-2 SN - 1866-9433 SN - 1866-9085 IS - 15 SP - 1 EP - 19 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Frank, Ulrike A1 - Frank, Katrin A1 - Mohr, Bettina A1 - Kurtenbach, Stephanie A1 - Khader-Lindholz, Aischa A1 - Sallat, Stephan A1 - Wagner, Lilli A1 - Düring, Sarah A1 - Lubitz, Anika A1 - Schnelle, Kirsten A1 - Klitsch, Julia A1 - Netzebandt, Jonka A1 - Fritsche, Tom A1 - Uhlemann, Charlotte A1 - Wartenburger, Isabell A1 - Hilton, Matt A1 - Neitzel, Isabel A1 - Schmidt, Johanna A1 - Eikerling, Maren A1 - Cholin, Joana A1 - Menze, Clara A1 - Stadie, Nicole A1 - Schmitz-Antonischki, Dorit A1 - Heide, Judith A1 - Plath, Almut A1 - Corsten, Sabine A1 - Hoffmann, Marie A1 - Leinweber, Juliane A1 - Spelter, Bianca A1 - Karstens, Sven ED - Tan, Sarah ED - Düring, Sarah ED - Wilde, Alina ED - Wunderlich, Hanna ED - Fritzsche, Tom T1 - Spektrum Patholinguistik Band 15. Schwerpunktthema: Interdisziplinär behandeln – Multiprofessionelle Zusammenarbeit in der Sprachtherapie T2 - Spektrum Patholinguistik N2 - Das 15. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Interdisziplinär (be-)handeln – Multiprofessionelle Zusammenarbeit in der Sprachtherapie« fand am 20.11.2021 als Online-Veranstaltung statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl), seit 2021 vom Deutschen Bundesverband für akademische Sprachtherapie und Logopädie (dbs) in Kooperation mit der Universität Potsdam durchgeführt. Der vorliegende Tagungsband beinhaltet die Vorträge zum Schwerpunktthema und Informationen aus der Podiumsdiskussion sowie die Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Fifteenth Autumn Meeting Patholinguistics with its main topic »Interdisciplinary treatment - multiprofessional cooperation in speech/language therapy« took place online on the 20th of November 2021. This annual meeting has been organised since 2007 by the Association for Patholinguistics (vpl), since 2021 by the German Federal Association for Academic Speech/Language Therapy and Logopaedics (dbs) in cooperation with the University of Potsdam. The present proceedings feature the keynote presentations on the main topic and information from the panel discussion as well as articles from the poster session covering a broad range of areas in research and practice of speech/language therapy. T3 - Spektrum Patholinguistik - 15 KW - Patholinguistik KW - Sprachtherapie KW - interdisziplinäre Behandlung KW - multiprofessionelle Zusammenarbeit KW - patholinguistics KW - speech/language therapy KW - interdisciplinary treatment KW - multiprofessional cooperation Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-558206 SN - 978-3-86956-542-2 SN - 1866-9433 SN - 1866-9085 IS - 15 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Tracy, Rosemarie A1 - Heide, Judith A1 - Wahl, Michael A1 - Triarchi-Herrmann, Vassilia A1 - Grimm, Angela A1 - Wotschack, Christiane A1 - Kulik, Sylvia A1 - Frank, Ulrike A1 - Klassert, Annegret A1 - Gagarina, Natalʹja Vladimirovna A1 - Kauschke, Christina A1 - Eicher, Iris A1 - Tsakmaki, Barbara A1 - Akkaya, Zeynep A1 - Castillo, Esmeralda A1 - Groba, Agnes A1 - Höhle, Barbara A1 - Miertsch, Barbara A1 - Hubert, Anja A1 - Sauerland, Uli A1 - Schröder, Caroline A1 - Stadie, Nicole A1 - Wittler, Marion A1 - Berendes, Karin A1 - Gottal, Stephanie A1 - Grabherr, Britta A1 - Zaps, Jennifer A1 - Ptok, Martin A1 - Hanne, Sandra A1 - Sekerina, Irina A. A1 - Vasishth, Shravan A1 - Burchert, Frank A1 - De Bleser, Ria A1 - Kleissendorf, Barbara A1 - Jaecks, Petra A1 - Stenneken, Prisca A1 - Fischer, Ivette A1 - Moedebeck, Petra ED - Heide, Judith ED - Hanne, Sandra ED - Brandt-Kobele, Oda-Christina ED - Fritzsche, Tom T1 - Spektrum Patholinguistik = Schwerpunktthema: Ein Kopf - Zwei Sprachen : Mehrsprachigkeit in Forschung und Therapie N2 - "Spektrum Patholinguistik" (Band 2) ist der Tagungsband zum 2. Herbsttreffen Patholinguistik, das der Verband für Patholinguistik (vpl) e.V. am 22.11.2008 an der Universität Potsdam veranstaltet hat. Zum Schwerpunktthema "Ein Kopf - Zwei Sprachen: Mehrsprachigkeit in Forschung und Therapie" sind die drei Hauptvorträge und vier Abstracts von Posterpräsentationen veröffentlicht. Desweiteren enthält der Tagungsband freie Beiträge, u.a. zu Satzverarbeitung und Agrammatismus, Lesestrategien und LRS, Prosodie-Entwicklung, kindlichen Aphasien, Dysphagie-Therapie sowie zu kognitiven Defiziten bei älteren Menschen. N2 - "Spektrum Patholinguistik" (vol. 2) contains the proceedings of the "2nd Herbsttreffen Patholinguistik" which was held at the University of Potsdam on November 22, 2008. Many talks and posters focused on bilingual language processing in normal and impaired speakers. The other contributions covered various topics, e.g. sentence processing and agrammatism, reading strategies and developmental dyslexia, language development, childhood aphasia, dysphagia therapy and cognitive skills in aging. T3 - Spektrum Patholinguistik - 2 KW - Patholinguistik KW - Bilingualismus KW - Mehrsprachigkeit KW - Sprachtherapie KW - Sprachförderung KW - patholinguistics KW - bilingualism KW - speech and language therapy Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30451 SN - 978-3-940793-89-8 SN - 1869-3822 SN - 1866-9433 IS - 2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Welke, Lisa-Marie A1 - Frank, Ulrike T1 - Pilotfragebogenstudie zur praktischen Umsetzung und Koordination des Trachealkanülen-Managements in Berlin und Brandenburg JF - Spektrum Patholinguistik Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437780 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 SP - 115 EP - 129 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Posse, Dorothea A1 - Frank, Ulrike T1 - Der Einfluss des Lee Silverman Voice Treatment (LSVT) auf die Hypernasalität bei Dysarthrie JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54313 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 185 EP - 187 ER - TY - JOUR A1 - Puritz, Caroline A1 - Seidl, Rainer Ottis A1 - Frank, Ulrike T1 - Die Auswirkungen des Lee Silverman Voice Treatments (LSVT) auf die kortikalen Repräsentationen der Schluckmuskulatur bei Patienten mit Morbus Parkinson JF - Spektrum Patholinguistik Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54322 SN - 1869-3822 SN - 1866-9433 IS - 4 SP - 189 EP - 191 ER - TY - JOUR A1 - Weiland, Linda A1 - Netzebandt, Jonka A1 - Frank, Ulrike T1 - Schluckstörungen bei HNO-Tumorpatienten BT - Eine Einzelfallstudie zur Dysphagietherapie mithilfe des sEMG-Biofeedback-Verfahrens JF - Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie N2 - 1. Einleitung, 2. Theoretischer Hintergrund, 3. Fragestellung und Hypothesen, 4. Methoden, 5. Ergebnisse, 6. Diskussion, 7. Literatur Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-99115 SN - 1866-9085 SN - 1866-9433 IS - 9 SP - 219 EP - 234 PB - Universitätsverlag Potsdam CY - Potsdam ER -