TY  - JOUR
A1  - van der Valk, Ralf J. P.
A1  - Kreiner-Moller, Eskil
A1  - Kooijman, Marjolein N.
A1  - Guxens, Monica
A1  - Stergiakouli, Evangelia
A1  - Saaf, Annika
A1  - Bradfield, Jonathan P.
A1  - Geller, Frank
A1  - Hayes, M. Geoffrey
A1  - Cousminer, Diana L.
A1  - Koerner, Antje
A1  - Thiering, Elisabeth
A1  - Curtin, John A.
A1  - Myhre, Ronny
A1  - Huikari, Ville
A1  - Joro, Raimo
A1  - Kerkhof, Marjan
A1  - Warrington, Nicole M.
A1  - Pitkanen, Niina
A1  - Ntalla, Ioanna
A1  - Horikoshi, Momoko
A1  - Veijola, Riitta
A1  - Freathy, Rachel M.
A1  - Teo, Yik-Ying
A1  - Barton, Sheila J.
A1  - Evans, David M.
A1  - Kemp, John P.
A1  - St Pourcain, Beate
A1  - Ring, Susan M.
A1  - Smith, George Davey
A1  - Bergstrom, Anna
A1  - Kull, Inger
A1  - Hakonarson, Hakon
A1  - Mentch, Frank D.
A1  - Bisgaard, Hans
A1  - Chawes, Bo Lund Krogsgaard
A1  - Stokholm, Jakob
A1  - Waage, Johannes
A1  - Eriksen, Patrick
A1  - Sevelsted, Astrid
A1  - Melbye, Mads
A1  - van Duijn, Cornelia M.
A1  - Medina-Gomez, Carolina
A1  - Hofman, Albert
A1  - de Jongste, Johan C.
A1  - Taal, H. Rob
A1  - Uitterlinden, Andre G.
A1  - Armstrong, Loren L.
A1  - Eriksson, Johan
A1  - Palotie, Aarno
A1  - Bustamante, Mariona
A1  - Estivill, Xavier
A1  - Gonzalez, Juan R.
A1  - Llop, Sabrina
A1  - Kiess, Wieland
A1  - Mahajan, Anubha
A1  - Flexeder, Claudia
A1  - Tiesler, Carla M. T.
A1  - Murray, Clare S.
A1  - Simpson, Angela
A1  - Magnus, Per
A1  - Sengpiel, Verena
A1  - Hartikainen, Anna-Liisa
A1  - Keinanen-Kiukaanniemi, Sirkka
A1  - Lewin, Alexandra
A1  - Alves, Alexessander Da Silva Couto
A1  - Blakemore, Alexandra I. F.
A1  - Buxton, Jessica L.
A1  - Kaakinen, Marika
A1  - Rodriguez, Alina
A1  - Sebert, Sylvain
A1  - Vaarasmaki, Marja
A1  - Lakka, Timo
A1  - Lindi, Virpi
A1  - Gehring, Ulrike
A1  - Postma, Dirkje S.
A1  - Ang, Wei
A1  - Newnham, John P.
A1  - Lyytikainen, Leo-Pekka
A1  - Pahkala, Katja
A1  - Raitakari, Olli T.
A1  - Panoutsopoulou, Kalliope
A1  - Zeggini, Eleftheria
A1  - Boomsma, Dorret I.
A1  - Groen-Blokhuis, Maria
A1  - Ilonen, Jorma
A1  - Franke, Lude
A1  - Hirschhorn, Joel N.
A1  - Pers, Tune H.
A1  - Liang, Liming
A1  - Huang, Jinyan
A1  - Hocher, Berthold
A1  - Knip, Mikael
A1  - Saw, Seang-Mei
A1  - Holloway, John W.
A1  - Melen, Erik
A1  - Grant, Struan F. A.
A1  - Feenstra, Bjarke
A1  - Lowe, William L.
A1  - Widen, Elisabeth
A1  - Sergeyev, Elena
A1  - Grallert, Harald
A1  - Custovic, Adnan
A1  - Jacobsson, Bo
A1  - Jarvelin, Marjo-Riitta
A1  - Atalay, Mustafa
A1  - Koppelman, Gerard H.
A1  - Pennell, Craig E.
A1  - Niinikoski, Harri
A1  - Dedoussis, George V.
A1  - Mccarthy, Mark I.
A1  - Frayling, Timothy M.
A1  - Sunyer, Jordi
A1  - Timpson, Nicholas J.
A1  - Rivadeneira, Fernando
A1  - Bonnelykke, Klaus
A1  - Jaddoe, Vincent W. V.
T1  - A novel common variant in DCST2 is associated with length in early life and height in adulthood
JF  - Human molecular genetics
N2  - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Y1  - 2015
U6  - https://doi.org/10.1093/hmg/ddu510
SN  - 0964-6906
SN  - 1460-2083
VL  - 24
IS  - 4
SP  - 1155
EP  - 1168
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Thonicke, Mady
A1  - Frank, Ulrike
T1  - Biofeedback in der Dysphagietherapie
BT  - Unterstützung therapeutischer Maßnahmen durch Oberflächen-Elektromyographie (sEMG)
JF  - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - geistige Behinderung
KW  - primär progessive Aphasie
KW  - patholinguistics
KW  - speech therapy
KW  - mental deficiency
KW  - primary progessive aphasia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79891
SP  - 243
EP  - 247
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Peiffers, Sabine
A1  - Frank, Ulrike
T1  - Der Einfluss von Körperparametern auf das Schluckvolumen bei gesunden Erwachsenen
JF  - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - geistige Behinderung
KW  - primär progessive Aphasie
KW  - patholinguistics
KW  - speech therapy
KW  - mental deficiency
KW  - primary progessive aphasia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79882
SP  - 239
EP  - 242
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Frank, Ulrike
A1  - Frank, Katrin
A1  - Zimmermann, Heinrich
T1  - Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation
JF  - Pneumologie : Zeitschrift für Pneumologie und Beatmungsmedizin
N2  - Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients.
Y1  - 2015
U6  - https://doi.org/10.1055/s-0034-1392359
SN  - 0934-8387
SN  - 1438-8790
VL  - 69
IS  - 7
SP  - 394
EP  - 399
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Frank, Ulrike
A1  - Frank, Katrin
A1  - Zimmermann, Heinrich
T1  - Effekte einer spezifischen Atemtherapie (Bagging) auf die Atem- und Schluckfunktion bei tracheotomierten Patienten
JF  - Spektrum Patholinguistik (Band 8) - Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - geistige Behinderung
KW  - primär progessive Aphasie
KW  - patholinguistics
KW  - speech therapy
KW  - mental deficiency
KW  - primary progessive aphasia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79873
SP  - 235
EP  - 237
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - CHAP
A1  - Frombach, Janna
A1  - Rancan, Fiorenza
A1  - Fleige, Emanuel
A1  - Haag, Rainer
A1  - Schumacher, Frank
A1  - Kleuser, Burkhard
A1  - Yamamoto, Kenji
A1  - Rühl, Eckart
A1  - Blume-Peytavi, Ulrike
A1  - Vogt, Annika
T1  - Skin penetration and dexamethasone release from polymer nanoparticles in ex vivo human skin
T2  - The journal of investigative dermatology
Y1  - 2015
SN  - 0022-202X
SN  - 1523-1747
VL  - 135
SP  - S52
EP  - S52
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Aktas, Maren
A1  - Succow, Juliane
A1  - Giel, Barbara
A1  - Dressel, Katharina
A1  - Lange, Inga
A1  - Hanne, Sandra
A1  - Burchert, Frank
A1  - Vasishth, Shravan
A1  - Schwytay, Jeannine
A1  - Breitenstein, Sarah
A1  - Fleischhauer, Elisabeth
A1  - Baumann, Jeannine
A1  - Preisinger, Irmhild
A1  - Siegmüller, Julia
A1  - Kuschmann, Anja
A1  - Ebert, Susanne
A1  - Lowit, Anja
A1  - Rath, Elisa
A1  - Heide, Judith
A1  - Lorenz, Antje
A1  - Wartenburger, Isabell
A1  - Hippeli, Carolin
A1  - Rausch, Monika
A1  - Würzner, Kay-Michael
A1  - Schroeder, Sascha
A1  - Czapka, Sophia
A1  - Klassert, Annegret
A1  - Reuters, Sabine
A1  - Frank, Ulrike
A1  - Frank, Katrin
A1  - Zimmermann, Heinrich
A1  - Peiffers, Sabine
A1  - Thonicke, Mady
ED  - Adelt, Anne
ED  - Otto, Constanze
ED  - Fritzsche, Tom
ED  - Magister, Caroline
T1  - Spektrum Patholinguistik = Schwerpunktthema: Besonders behandeln? : Sprachtherapie im Rahmen primärer Störungsbilder
N2  - Das 8. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Besonders behandeln? Sprachtherapie im Rahmen primärer Störungsbilder" fand am 15.11.2014 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. 
Der vorliegende Tagungsband beinhaltet die vier Hauptvorträge zum Schwerpunktthema, die vier Kurzvorträge aus dem Spektrum Patholinguisitk sowie die Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.
N2  - The Eighth Autumn Meeting Patholinguistics ('Herbsttreffen Patholinguistik') with its main topic "Special treatment? Language therapy in the context of primary disorders" took place in Potsdam on November 15 2014. This annual meeting has been organized since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). 
The present proceedings contain the four keynote talks on the main topic, the four short talks from the series 'Spectrum Patholinguistics', as well as the contributions of the poster session from all areas of speech/language therapy research and practice.
T3  - Spektrum Patholinguistik - 8 
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - geistige Behinderung
KW  - primär progessive Aphasie
KW  - patholinguistics
KW  - speech therapy
KW  - mental deficiency
KW  - primary progessive aphasia
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-77147
SN  - 978-3-86956-335-0
SN  - 1869-3822
SN  - 1866-9433
IS  - 8
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  -