TY  - RPRT
A1  - Brodeur, Abel
A1  - Mikola, Derek
A1  - Cook, Nikolai
A1  - Brailey, Thomas
A1  - Briggs, Ryan
A1  - Gendre, Alexandra de
A1  - Dupraz, Yannick
A1  - Fiala, Lenka
A1  - Gabani, Jacopo
A1  - Gauriot, Romain
A1  - Haddad, Joanne
A1  - Lima, Goncalo
A1  - Ankel-Peters, Jörg
A1  - Dreber, Anna
A1  - Campbell, Douglas
A1  - Kattan, Lamis
A1  - Fages, Diego Marino
A1  - Mierisch, Fabian
A1  - Sun, Pu
A1  - Wright, Taylor
A1  - Connolly, Marie
A1  - Hoces de la Guardia, Fernando
A1  - Johannesson, Magnus
A1  - Miguel, Edward
A1  - Vilhuber, Lars
A1  - Abarca, Alejandro
A1  - Acharya, Mahesh
A1  - Adjisse, Sossou Simplice
A1  - Akhtar, Ahwaz
A1  - Lizardi, Eduardo Alberto Ramirez
A1  - Albrecht, Sabina
A1  - Andersen, Synve Nygaard
A1  - Andlib, Zubaria
A1  - Arrora, Falak
A1  - Ash, Thomas
A1  - Bacher, Etienne
A1  - Bachler, Sebastian
A1  - Bacon, Félix
A1  - Bagues, Manuel
A1  - Balogh, Timea
A1  - Batmanov, Alisher
A1  - Barschkett, Mara
A1  - Basdil, B. Kaan
A1  - Dower, Jaromneda
A1  - Castek, Ondrej
A1  - Caviglia-Harris, Jill
A1  - Strand, Gabriella Chauca
A1  - Chen, Shi
A1  - Chzhen, Asya
A1  - Chung, Jong
A1  - Collins, Jason
A1  - Coppock, Alexander
A1  - Cordeau, Hugo
A1  - Couillard, Ben
A1  - Crechet, Jonathan
A1  - Crippa, Lorenzo
A1  - Cui, Jeanne
A1  - Czymara, Christian
A1  - Daarstad, Haley
A1  - Dao, Danh Chi
A1  - Dao, Dong
A1  - Schmandt, Marco David
A1  - Linde, Astrid de
A1  - Melo, Lucas De
A1  - Deer, Lachlan
A1  - Vera, Micole De
A1  - Dimitrova, Velichka
A1  - Dollbaum, Jan Fabian
A1  - Dollbaum, Jan Matti
A1  - Donnelly, Michael
A1  - Huynh, Luu Duc Toan
A1  - Dumbalska, Tsvetomira
A1  - Duncan, Jamie
A1  - Duong, Kiet Tuan
A1  - Duprey, Thibaut
A1  - Dworschak, Christoph
A1  - Ellingsrud, Sigmund
A1  - Elminejad, Ali
A1  - Eissa, Yasmine
A1  - Erhart, Andrea
A1  - Etingin-Frati, Giulian
A1  - Fatemi-Pour, Elaheh
A1  - Federice, Alexa
A1  - Feld, Jan
A1  - Fenig, Guidon
A1  - Firouzjaeiangalougah, Mojtaba
A1  - Fleisje, Erlend
A1  - Fortier-Chouinard, Alexandre
A1  - Engel, Julia Francesca
A1  - Fries, Tilman
A1  - Fortier, Reid
A1  - Fréchet, Nadjim
A1  - Galipeau, Thomas
A1  - Gallegos, Sebastián
A1  - Gangji, Areez
A1  - Gao, Xiaoying
A1  - Garnache, Cloé
A1  - Gáspár, Attila
A1  - Gavrilova, Evelina
A1  - Ghosh, Arijit
A1  - Gibney, Garreth
A1  - Gibson, Grant
A1  - Godager, Geir
A1  - Goff, Leonard
A1  - Gong, Da
A1  - González, Javier
A1  - Gretton, Jeremy
A1  - Griffa, Cristina
A1  - Grigoryeva, Idaliya
A1  - Grtting, Maja
A1  - Guntermann, Eric
A1  - Guo, Jiaqi
A1  - Gugushvili, Alexi
A1  - Habibnia, Hooman
A1  - Häffner, Sonja
A1  - Hall, Jonathan D.
A1  - Hammar, Olle
A1  - Kordt, Amund Hanson
A1  - Hashimoto, Barry
A1  - Hartley, Jonathan S.
A1  - Hausladen, Carina I.
A1  - Havránek, Tomáš
A1  - Hazen, Jacob
A1  - He, Harry
A1  - Hepplewhite, Matthew
A1  - Herrera-Rodriguez, Mario
A1  - Heuer, Felix
A1  - Heyes, Anthony
A1  - Ho, Anson T. Y.
A1  - Holmes, Jonathan
A1  - Holzknecht, Armando
A1  - Hsu, Yu-Hsiang Dexter
A1  - Hu, Shiang-Hung
A1  - Huang, Yu-Shiuan
A1  - Huebener, Mathias
A1  - Huber, Christoph
A1  - Huynh, Kim P.
A1  - Irsova, Zuzana
A1  - Isler, Ozan
A1  - Jakobsson, Niklas
A1  - Frith, Michael James
A1  - Jananji, Raphaël
A1  - Jayalath, Tharaka A.
A1  - Jetter, Michael
A1  - John, Jenny
A1  - Forshaw, Rachel Joy
A1  - Juan, Felipe
A1  - Kadriu, Valon
A1  - Karim, Sunny
A1  - Kelly, Edmund
A1  - Dang, Duy Khanh Hoang
A1  - Khushboo, Tazia
A1  - Kim, Jin
A1  - Kjellsson, Gustav
A1  - Kjelsrud, Anders
A1  - Kotsadam, Andreas
A1  - Korpershoek, Jori
A1  - Krashinsky, Lewis
A1  - Kundu, Suranjana
A1  - Kustov, Alexander
A1  - Lalayev, Nurlan
A1  - Langlois, Audrée
A1  - Laufer, Jill
A1  - Lee-Whiting, Blake
A1  - Leibing, Andreas
A1  - Lenz, Gabriel
A1  - Levin, Joel
A1  - Li, Peng
A1  - Li, Tongzhe
A1  - Lin, Yuchen
A1  - Listo, Ariel
A1  - Liu, Dan
A1  - Lu, Xuewen
A1  - Lukmanova, Elvina
A1  - Luscombe, Alex
A1  - Lusher, Lester R.
A1  - Lyu, Ke
A1  - Ma, Hai
A1  - Mäder, Nicolas
A1  - Makate, Clifton
A1  - Malmberg, Alice
A1  - Maitra, Adit
A1  - Mandas, Marco
A1  - Marcus, Jan
A1  - Margaryan, Shushanik
A1  - Márk, Lili
A1  - Martignano, Andres
A1  - Marsh, Abigail
A1  - Masetto, Isabella
A1  - McCanny, Anthony
A1  - McManus, Emma
A1  - McWay, Ryan
A1  - Metson, Lennard
A1  - Kinge, Jonas Minet
A1  - Mishra, Sumit
A1  - Mohnen, Myra
A1  - Möller, Jakob
A1  - Montambeault, Rosalie
A1  - Montpetit, Sébastien
A1  - Morin, Louis-Philippe
A1  - Morris, Todd
A1  - Moser, Scott
A1  - Motoki, Fabio
A1  - Muehlenbachs, Lucija
A1  - Musulan, Andreea
A1  - Musumeci, Marco
A1  - Nabin, Munirul
A1  - Nchare, Karim
A1  - Neubauer, Florian
A1  - Nguyen, Quan M. P.
A1  - Nguyen, Tuan
A1  - Nguyen-Tien, Viet
A1  - Niazi, Ali
A1  - Nikolaishvili, Giorgi
A1  - Nordstrom, Ardyn
A1  - Nü, Patrick
A1  - Odermatt, Angela
A1  - Olson, Matt
A1  - ien, Henning
A1  - Ölkers, Tim
A1  - Vert, Miquel Oliver i.
A1  - Oral, Emre
A1  - Oswald, Christian
A1  - Ousman, Ali
A1  - Özak, Ömer
A1  - Pandey, Shubham
A1  - Pavlov, Alexandre
A1  - Pelli, Martino
A1  - Penheiro, Romeo
A1  - Park, RyuGyung
A1  - Martel, Eva Pérez
A1  - Petrovičová, Tereza
A1  - Phan, Linh
A1  - Prettyman, Alexa
A1  - Procházka, Jakub
A1  - Putri, Aqila
A1  - Quandt, Julian
A1  - Qiu, Kangyu
A1  - Nguyen, Loan Quynh Thi
A1  - Rahman, Andaleeb
A1  - Rea, Carson H.
A1  - Reiremo, Adam
A1  - Renée, Laëtitia
A1  - Richardson, Joseph
A1  - Rivers, Nicholas
A1  - Rodrigues, Bruno
A1  - Roelofs, William
A1  - Roemer, Tobias
A1  - Rogeberg, Ole
A1  - Rose, Julian
A1  - Roskos-Ewoldsen, Andrew
A1  - Rosmer, Paul
A1  - Sabada, Barbara
A1  - Saberian, Soodeh
A1  - Salamanca, Nicolas
A1  - Sator, Georg
A1  - Sawyer, Antoine
A1  - Scates, Daniel
A1  - Schlüter, Elmar
A1  - Sells, Cameron
A1  - Sen, Sharmi
A1  - Sethi, Ritika
A1  - Shcherbiak, Anna
A1  - Sogaolu, Moyosore
A1  - Soosalu, Matt
A1  - Srensen, Erik
A1  - Sovani, Manali
A1  - Spencer, Noah
A1  - Staubli, Stefan
A1  - Stans, Renske
A1  - Stewart, Anya
A1  - Stips, Felix
A1  - Stockley, Kieran
A1  - Strobel, Stephenson
A1  - Struby, Ethan
A1  - Tang, John
A1  - Tanrisever, Idil
A1  - Yang, Thomas Tao
A1  - Tastan, Ipek
A1  - Tatić, Dejan
A1  - Tatlow, Benjamin
A1  - Seuyong, Féraud Tchuisseu
A1  - Thériault, Rémi
A1  - Thivierge, Vincent
A1  - Tian, Wenjie
A1  - Toma, Filip-Mihai
A1  - Totarelli, Maddalena
A1  - Tran, Van-Anh
A1  - Truong, Hung
A1  - Tsoy, Nikita
A1  - Tuzcuoglu, Kerem
A1  - Ubfal, Diego
A1  - Villalobos, Laura
A1  - Walterskirchen, Julian
A1  - Wang, Joseph Taoyi
A1  - Wattal, Vasudha
A1  - Webb, Matthew D.
A1  - Weber, Bryan
A1  - Weisser, Reinhard
A1  - Weng, Wei-Chien
A1  - Westheide, Christian
A1  - White, Kimberly
A1  - Winter, Jacob
A1  - Wochner, Timo
A1  - Woerman, Matt
A1  - Wong, Jared
A1  - Woodard, Ritchie
A1  - Wroński, Marcin
A1  - Yazbeck, Myra
A1  - Yang, Gustav Chung
A1  - Yap, Luther
A1  - Yassin, Kareman
A1  - Ye, Hao
A1  - Yoon, Jin Young
A1  - Yurris, Chris
A1  - Zahra, Tahreen
A1  - Zaneva, Mirela
A1  - Zayat, Aline
A1  - Zhang, Jonathan
A1  - Zhao, Ziwei
A1  - Yaolang, Zhong
T1  - Mass reproducibility and replicability
BT  - a new hope
T2  - I4R discussion paper series
N2  - This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes.
KW  - conomics
KW  - open science
KW  - political science
KW  - replication
KW  - reproduction
KW  - research transparency
Y1  - 2024
SN  - 2752-1931
IS  - 107
PB  - Institute for Replication
CY  - Essen
ER  - 
TY  - JOUR
A1  - Taal, H. Rob
A1  - St Pourcain, Beate
A1  - Thiering, Elisabeth
A1  - Das, Shikta
A1  - Mook-Kanamori, Dennis O.
A1  - Warrington, Nicole M.
A1  - Kaakinen, Marika
A1  - Kreiner-Moller, Eskil
A1  - Bradfield, Jonathan P.
A1  - Freathy, Rachel M.
A1  - Geller, Frank
A1  - Guxens, Monica
A1  - Cousminer, Diana L.
A1  - Kerkhof, Marjan
A1  - Timpson, Nicholas J.
A1  - Ikram, M. Arfan
A1  - Beilin, Lawrence J.
A1  - Bonnelykke, Klaus
A1  - Buxton, Jessica L.
A1  - Charoen, Pimphen
A1  - Chawes, Bo Lund Krogsgaard
A1  - Eriksson, Johan
A1  - Evans, David M.
A1  - Hofman, Albert
A1  - Kemp, John P.
A1  - Kim, Cecilia E.
A1  - Klopp, Norman
A1  - Lahti, Jari
A1  - Lye, Stephen J.
A1  - McMahon, George
A1  - Mentch, Frank D.
A1  - Mueller-Nurasyid, Martina
A1  - O'Reilly, Paul F.
A1  - Prokopenko, Inga
A1  - Rivadeneira, Fernando
A1  - Steegers, Eric A. P.
A1  - Sunyer, Jordi
A1  - Tiesler, Carla
A1  - Yaghootkar, Hanieh
A1  - Breteler, Monique M. B.
A1  - Debette, Stephanie
A1  - Fornage, Myriam
A1  - Gudnason, Vilmundur
A1  - Launer, Lenore J.
A1  - van der Lugt, Aad
A1  - Mosley, Thomas H.
A1  - Seshadri, Sudha
A1  - Smith, Albert V.
A1  - Vernooij, Meike W.
A1  - Blakemore, Alexandra I. F.
A1  - Chiavacci, Rosetta M.
A1  - Feenstra, Bjarke
A1  - Fernandez-Banet, Julio
A1  - Grant, Struan F. A.
A1  - Hartikainen, Anna-Liisa
A1  - van der Heijden, Albert J.
A1  - Iniguez, Carmen
A1  - Lathrop, Mark
A1  - McArdle, Wendy L.
A1  - Molgaard, Anne
A1  - Newnham, John P.
A1  - Palmer, Lyle J.
A1  - Palotie, Aarno
A1  - Pouta, Annneli
A1  - Ring, Susan M.
A1  - Sovio, Ulla
A1  - Standl, Marie
A1  - Uitterlinden, Andre G.
A1  - Wichmann, H-Erich
A1  - Vissing, Nadja Hawwa
A1  - DeCarli, Charles
A1  - van Duijn, Cornelia M.
A1  - McCarthy, Mark I.
A1  - Koppelman, Gerard H.
A1  - Estivill, Xavier
A1  - Hattersley, Andrew T.
A1  - Melbye, Mads
A1  - Bisgaard, Hans
A1  - Pennell, Craig E.
A1  - Widen, Elisabeth
A1  - Hakonarson, Hakon
A1  - Smith, George Davey
A1  - Heinrich, Joachim
A1  - Jarvelin, Marjo-Riitta
A1  - Jaddoe, Vincent W. V.
A1  - Adair, Linda S.
A1  - Ang, Wei
A1  - Atalay, Mustafa
A1  - van Beijsterveldt, Toos
A1  - Bergen, Nienke
A1  - Benke, Kelly
A1  - Berry, Diane J.
A1  - Bradfield, Jonathan P.
A1  - Charoen, Pimphen
A1  - Coin, Lachlan
A1  - Cousminer, Diana L.
A1  - Das, Shikta
A1  - Davis, Oliver S. P.
A1  - Elliott, Paul
A1  - Evans, David M.
A1  - Feenstra, Bjarke
A1  - Flexeder, Claudia
A1  - Frayling, Tim
A1  - Freathy, Rachel M.
A1  - Gaillard, Romy
A1  - Geller, Frank
A1  - Groen-Blokhuis, Maria
A1  - Goh, Liang-Kee
A1  - Guxens, Monica
A1  - Haworth, Claire M. A.
A1  - Hadley, Dexter
A1  - Hebebrand, Johannes
A1  - Hinney, Anke
A1  - Hirschhorn, Joel N.
A1  - Holloway, John W.
A1  - Holst, Claus
A1  - Hottenga, Jouke Jan
A1  - Horikoshi, Momoko
A1  - Huikari, Ville
A1  - Hypponen, Elina
A1  - Iniguez, Carmen
A1  - Kaakinen, Marika
A1  - Kilpelainen, Tuomas O.
A1  - Kirin, Mirna
A1  - Kowgier, Matthew
A1  - Lakka, Hanna-Maaria
A1  - Lange, Leslie A.
A1  - Lawlor, Debbie A.
A1  - Lehtimaki, Terho
A1  - Lewin, Alex
A1  - Lindgren, Cecilia
A1  - Lindi, Virpi
A1  - Maggi, Reedik
A1  - Marsh, Julie
A1  - Middeldorp, Christel
A1  - Millwood, Iona
A1  - Mook-Kanamori, Dennis O.
A1  - Murray, Jeffrey C.
A1  - Nivard, Michel
A1  - Nohr, Ellen Aagaard
A1  - Ntalla, Ioanna
A1  - Oken, Emily
A1  - O'Reilly, Paul F.
A1  - Palmer, Lyle J.
A1  - Panoutsopoulou, Kalliope
A1  - Pararajasingham, Jennifer
A1  - Prokopenko, Inga
A1  - Rodriguez, Alina
A1  - Salem, Rany M.
A1  - Sebert, Sylvain
A1  - Siitonen, Niina
A1  - Sovio, Ulla
A1  - St Pourcain, Beate
A1  - Strachan, David P.
A1  - Sunyer, Jordi
A1  - Taal, H. Rob
A1  - Teo, Yik-Ying
A1  - Thiering, Elisabeth
A1  - Tiesler, Carla
A1  - Uitterlinden, Andre G.
A1  - Valcarcel, Beatriz
A1  - Warrington, Nicole M.
A1  - White, Scott
A1  - Willemsen, Gonneke
A1  - Yaghootkar, Hanieh
A1  - Zeggini, Eleftheria
A1  - Boomsma, Dorret I.
A1  - Cooper, Cyrus
A1  - Estivill, Xavier
A1  - Gillman, Matthew
A1  - Grant, Struan F. A.
A1  - Hakonarson, Hakon
A1  - Hattersley, Andrew T.
A1  - Heinrich, Joachim
A1  - Hocher, Berthold
A1  - Jaddoe, Vincent W. V.
A1  - Jarvelin, Marjo-Riitta
A1  - Lakka, Timo A.
A1  - McCarthy, Mark I.
A1  - Melbye, Mads
A1  - Mohlke, Karen L.
A1  - Dedoussis, George V.
A1  - Ong, Ken K.
A1  - Pearson, Ewan R.
A1  - Pennell, Craig E.
A1  - Price, Thomas S.
A1  - Power, Chris
A1  - Raitakari, Olli T.
A1  - Saw, Seang-Mei
A1  - Scherag, Andre
A1  - Simell, Olli
A1  - Sorensen, Thorkild I. A.
A1  - Timpson, Nicholas J.
A1  - Widen, Elisabeth
A1  - Wilson, James F.
A1  - Ang, Wei
A1  - van Beijsterveldt, Toos
A1  - Bergen, Nienke
A1  - Benke, Kelly
A1  - Berry, Diane J.
A1  - Bradfield, Jonathan P.
A1  - Charoen, Pimphen
A1  - Coin, Lachlan
A1  - Cousminer, Diana L.
A1  - Das, Shikta
A1  - Elliott, Paul
A1  - Evans, David M.
A1  - Frayling, Tim
A1  - Freathy, Rachel M.
A1  - Gaillard, Romy
A1  - Groen-Blokhuis, Maria
A1  - Guxens, Monica
A1  - Hadley, Dexter
A1  - Hottenga, Jouke Jan
A1  - Huikari, Ville
A1  - Hypponen, Elina
A1  - Kaakinen, Marika
A1  - Kowgier, Matthew
A1  - Lawlor, Debbie A.
A1  - Lewin, Alex
A1  - Lindgren, Cecilia
A1  - Marsh, Julie
A1  - Middeldorp, Christel
A1  - Millwood, Iona
A1  - Mook-Kanamori, Dennis O.
A1  - Nivard, Michel
A1  - O'Reilly, Paul F.
A1  - Palmer, Lyle J.
A1  - Prokopenko, Inga
A1  - Rodriguez, Alina
A1  - Sebert, Sylvain
A1  - Sovio, Ulla
A1  - St Pourcain, Beate
A1  - Standl, Marie
A1  - Strachan, David P.
A1  - Sunyer, Jordi
A1  - Taal, H. Rob
A1  - Thiering, Elisabeth
A1  - Tiesler, Carla
A1  - Uitterlinden, Andre G.
A1  - Valcarcel, Beatriz
A1  - Warrington, Nicole M.
A1  - White, Scott
A1  - Willemsen, Gonneke
A1  - Yaghootkar, Hanieh
A1  - Boomsma, Dorret I.
A1  - Estivill, Xavier
A1  - Grant, Struan F. A.
A1  - Hakonarson, Hakon
A1  - Hattersley, Andrew T.
A1  - Heinrich, Joachim
A1  - Jaddoe, Vincent W. V.
A1  - Jarvelin, Marjo-Riitta
A1  - McCarthy, Mark I.
A1  - Pennell, Craig E.
A1  - Power, Chris
A1  - Timpson, Nicholas J.
A1  - Widen, Elisabeth
A1  - Ikram, M. Arfan
A1  - Fornage, Myriam
A1  - Smith, Albert V.
A1  - Seshadri, Sudha
A1  - Schmidt, Reinhold
A1  - Debette, Stephanie
A1  - Vrooman, Henri A.
A1  - Sigurdsson, Sigurdur
A1  - Ropele, Stefan
A1  - Coker, Laura H.
A1  - Longstreth, W. T.
A1  - Niessen, Wiro J.
A1  - DeStefano, Anita L.
A1  - Beiser, Alexa
A1  - Zijdenbos, Alex P.
A1  - Struchalin, Maksim
A1  - Jack, Clifford R.
A1  - Nalls, Mike A.
A1  - Au, Rhoda
A1  - Hofman, Albert
A1  - Gudnason, Haukur
A1  - van der Lugt, Aad
A1  - Harris, Tamara B.
A1  - Meeks, William M.
A1  - Vernooij, Meike W.
A1  - van Buchem, Mark A.
A1  - Catellier, Diane
A1  - Gudnason, Vilmundur
A1  - Windham, B. Gwen
A1  - Wolf, Philip A.
A1  - van Duijn, Cornelia M.
A1  - Mosley, Thomas H.
A1  - Schmidt, Helena
A1  - Launer, Lenore J.
A1  - Breteler, Monique M. B.
A1  - DeCarli, Charles
T1  - Common variants at 12q15 and 12q24 are associated with infant head circumference
JF  - Nature genetics
N2  - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
Y1  - 2012
U6  - https://doi.org/10.1038/ng.2238
SN  - 1061-4036
VL  - 44
IS  - 5
SP  - 532
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Kastl, Johanna
A1  - Braun, Joachim
A1  - Prestel, Andreas
A1  - Möller, Heiko Michael
A1  - Huhn, Thomas
A1  - Mayer, Thomas U.
T1  - Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint
JF  - ACS chemical biology
N2  - The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge, a cellular surveillance mechanism, termed the spindle assembly checkpoint (SAC), evolved that monitors the correct attachment of chromosomes and blocks progression through mitosis if corrections are needed. While the central role of the SAC for genome integrity is well established, its functional dissection has been hampered by the limited availability of appropriate small molecule inhibitors. Using a fluorescence polarization-based screen, we identify Mad2 inhibitor-1 (M2I-1), the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. Based on computational and biochemical analyses, we propose that M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells. Thus, our study identifies the SAC specific complex formation between Mad2 and Cdc20 as a protein-protein interaction that can be targeted by small molecules.
Y1  - 2015
U6  - https://doi.org/10.1021/acschembio.5b00121
SN  - 1554-8929
SN  - 1554-8937
VL  - 10
IS  - 7
SP  - 1661
EP  - 1666
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Radchuk, Viktoriia
A1  - Reed, Thomas
A1  - Teplitsky, Celine
A1  - van de Pol, Martijn
A1  - Charmantier, Anne
A1  - Hassall, Christopher
A1  - Adamik, Peter
A1  - Adriaensen, Frank
A1  - Ahola, Markus P.
A1  - Arcese, Peter
A1  - Miguel Aviles, Jesus
A1  - Balbontin, Javier
A1  - Berg, Karl S.
A1  - Borras, Antoni
A1  - Burthe, Sarah
A1  - Clobert, Jean
A1  - Dehnhard, Nina
A1  - de Lope, Florentino
A1  - Dhondt, Andre A.
A1  - Dingemanse, Niels J.
A1  - Doi, Hideyuki
A1  - Eeva, Tapio
A1  - Fickel, Jörns
A1  - Filella, Iolanda
A1  - Fossoy, Frode
A1  - Goodenough, Anne E.
A1  - Hall, Stephen J. G.
A1  - Hansson, Bengt
A1  - Harris, Michael
A1  - Hasselquist, Dennis
A1  - Hickler, Thomas
A1  - Jasmin Radha, Jasmin
A1  - Kharouba, Heather
A1  - Gabriel Martinez, Juan
A1  - Mihoub, Jean-Baptiste
A1  - Mills, James A.
A1  - Molina-Morales, Mercedes
A1  - Moksnes, Arne
A1  - Ozgul, Arpat
A1  - Parejo, Deseada
A1  - Pilard, Philippe
A1  - Poisbleau, Maud
A1  - Rousset, Francois
A1  - Rödel, Mark-Oliver
A1  - Scott, David
A1  - Carlos Senar, Juan
A1  - Stefanescu, Constanti
A1  - Stokke, Bard G.
A1  - Kusano, Tamotsu
A1  - Tarka, Maja
A1  - Tarwater, Corey E.
A1  - Thonicke, Kirsten
A1  - Thorley, Jack
A1  - Wilting, Andreas
A1  - Tryjanowski, Piotr
A1  - Merila, Juha
A1  - Sheldon, Ben C.
A1  - Moller, Anders Pape
A1  - Matthysen, Erik
A1  - Janzen, Fredric
A1  - Dobson, F. Stephen
A1  - Visser, Marcel E.
A1  - Beissinger, Steven R.
A1  - Courtiol, Alexandre
A1  - Kramer-Schadt, Stephanie
T1  - Adaptive responses of animals to climate change are most likely insufficient
JF  - Nature Communications
N2  - Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-10924-4
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - de Vera, Jean-Pierre Paul
A1  - Böttger, Ute
A1  - de la Torre Nötzel, Rosa
A1  - Sanchez, Francisco J.
A1  - Grunow, Dana
A1  - Schmitz, Nicole
A1  - Lange, Caroline
A1  - Hübers, Heinz-Wilhelm
A1  - Billi, Daniela
A1  - Baque, Mickael
A1  - Rettberg, Petra
A1  - Rabbow, Elke
A1  - Reitz, Günther
A1  - Berger, Thomas
A1  - Möller, Ralf
A1  - Bohmeier, Maria
A1  - Horneck, Gerda
A1  - Westall, Frances
A1  - Jänchen, Jochen
A1  - Fritz, Jörg
A1  - Meyer, Cornelia
A1  - Onofri, Silvano
A1  - Selbmann, Laura
A1  - Zucconi, Laura
A1  - Kozyrovska, Natalia
A1  - Leya, Thomas
A1  - Foing, Bernard
A1  - Demets, Rene
A1  - Cockell, Charles S.
A1  - Bryce, Casey
A1  - Wagner, Dirk
A1  - Serrano, Paloma
A1  - Edwards, Howell G. M.
A1  - Joshi, Jasmin Radha
A1  - Huwe, Björn
A1  - Ehrenfreund, Pascale
A1  - Elsaesser, Andreas
A1  - Ott, Sieglinde
A1  - Meessen, Joachim
A1  - Feyh, Nina
A1  - Szewzyk, Ulrich
A1  - Jaumann, Ralf
A1  - Spohn, Tilman
T1  - Supporting Mars exploration BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology
JF  - Planetary and space science
N2  - The Low Earth Orbit (LEO) experiment Biology and Mars Experiment (BIOMEX) is an interdisciplinary and international space research project selected by ESA. The experiment will be accommodated on the space exposure facility EXPOSE-R2 on the International Space Station (ISS) and is foreseen to be launched in 2013. The prime objective of BIOMEX is to measure to what extent biomolecules, such as pigments and cellular components, are resistant to and able to maintain their stability under space and Mars-like conditions. The results of BIOMEX will be relevant for space proven biosignature definition and for building a biosignature data base (e.g. the proposed creation of an international Raman library). The library will be highly relevant for future space missions such as the search for life on Mars. The secondary scientific objective is to analyze to what extent terrestrial extremophiles are able to survive in space and to determine which interactions between biological samples and selected minerals (including terrestrial, Moon- and Mars analogs) can be observed under space and Mars-like conditions. In this context, the Moon will be an additional platform for performing similar experiments with negligible magnetic shielding and higher solar and galactic irradiation compared to LEO. Using the Moon as an additional astrobiological exposure platform to complement ongoing astrobiological LEO investigations could thus enhance the chances of detecting organic traces of life on Mars. We present a lunar lander mission with two related objectives: a lunar lander equipped with Raman and PanCam instruments which can analyze the lunar surface and survey an astrobiological exposure platform. This dual use of testing mission technology together with geo- and astrobiological analyses will significantly increase the science return, and support the human preparation objectives. It will provide knowledge about the Moon's surface itself and, in addition, monitor the stability of life-markers, such as cells, cell components and pigments, in an extraterrestrial environment with much closer radiation properties to the surface of Mars. The combination of a Raman data base of these data together with data from LEO and space simulation experiments, will lead to further progress on the analysis and interpretation of data that we will obtain from future Moon and Mars exploration missions.
KW  - Moon
KW  - Mars
KW  - Low Earth Orbit
KW  - Astrobiology
KW  - Instrumentation
KW  - Spectroscopy
KW  - Biosignature
Y1  - 2012
U6  - https://doi.org/10.1016/j.pss.2012.06.010
SN  - 0032-0633
VL  - 74
IS  - 1
SP  - 103
EP  - 110
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Trautwein, Matthias
A1  - Fredriksson, Kai
A1  - Möller, Heiko Michael
A1  - Exner, Thomas E.
T1  - Automated assignment of NMR chemical shifts based on a known structure and 4D spectra
JF  - Journal of biomolecular NMR
N2  - Apart from their central role during 3D structure determination of proteins the backbone chemical shift assignment is the basis for a number of applications, like chemical shift perturbation mapping and studies on the dynamics of proteins. This assignment is not a trivial task even if a 3D protein structure is known and needs almost as much effort as the assignment for structure prediction if performed manually. We present here a new algorithm based solely on 4D [H-1, N-15]-HSQC-NOESY-[H-1, N-15]-HSQC spectra which is able to assign a large percentage of chemical shifts (73-82 %) unambiguously, demonstrated with proteins up to a size of 250 residues. For the remaining residues, a small number of possible assignments is filtered out. This is done by comparing distances in the 3D structure to restraints obtained from the peak volumes in the 4D spectrum. Using dead-end elimination, assignments are removed in which at least one of the restraints is violated. Including additional information from chemical shift predictions, a complete unambiguous assignment was obtained for Ubiquitin and 95 % of the residues were correctly assigned in the 251 residue-long N-terminal domain of enzyme I. The program including source code is available at https://github.com/thomasexner/4Dassign.
KW  - Chemical shift assignment
KW  - Protein
KW  - 3D structure
KW  - 4D NOESY
Y1  - 2016
U6  - https://doi.org/10.1007/s10858-016-0050-0
SN  - 0925-2738
SN  - 1573-5001
VL  - 65
SP  - 217
EP  - 236
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Hanisch, Uwe-Karsten
A1  - van Rossum, D.
A1  - Gast, Klaus
A1  - Misselwitz, Rolf
A1  - Goldstein, Gundars
A1  - Koistinaho, Jari
A1  - Möller, Thomas
T1  - The microglia-activating potential of thrombin : is the protease able to induce cyto- and chemokines?
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Hanisch, Uwe-Karsten
A1  - Van Rossum, Denise
A1  - Xie, Yiheng
A1  - Misselwitz, Rolf
A1  - Auriola, Seppo
A1  - Goldstein, Gundars
A1  - Koistinaho, Jari
A1  - Kettemann, Helmut
A1  - Möller, Thomas
A1  - Gast, Klaus
T1  - The microglia-activating potential of thrombin : the protease is not involved in the induction of proinflammatory cytokines and chemokines
N2  - The serine protease thrombin is known as a blood coagulation factor. Through limited cleavage of proteinase- activated receptors it can also control growth and functions in various cell types, including neurons, astrocytes, and microglia ( brain macrophages). A number of previous studies indicated that thrombin induces the release of proinflammatory cytokines and chemokines from microglial cells, suggesting another important role for the protease beyond hemostasis. In the present report, we provide evidence that this effect is not mediated by any proteolytic or non- proteolytic mechanism involving thrombin proper. Inhibition of the enzymatic thrombin activity did not affect the microglial release response. Instead the cyto-/chemokine-inducing activity solely resided in a high molecular weight protein fraction that could be isolated in trace amounts even from apparently homogenous alpha- and gamma-thrombin preparations. High molecular weight material contained thrombin-derived peptides as revealed by mass spectrometry but was devoid of thrombin-like enzymatic activity. Separated from the high molecular weight fraction by fast protein liquid chromatography, enzymatically intact alpha- and gamma-thrombin failed to trigger any release. Our findings may force a revision of the notion that thrombin itself is a direct proinflammatory release signal for microglia. In addition, they could be relevant for the study of other cellular activities and their assignment to this protease
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Debatin, Franziska
A1  - Möllmer, Jens
A1  - Mondal, Suvendu Sekhar
A1  - Behrens, Karsten
A1  - Möller, Andreas
A1  - Staudt, Reiner
A1  - Thomas, Arne
A1  - Holdt, Hans-Jürgen
T1  - Mixed gas adsorption of carbon dioxide and methane on a series of isoreticular microporous metal-organic frameworks based on 2-substituted imidazolate-4-amide-5-imidates
JF  - Journal of materials chemistry
N2  - In this work the adsorption of CO2 and CH4 on a series of isoreticular microporous metal-organic frameworks based on 2-substituted imidazolate-4-amide-5-imidates, IFP-1-IFP-6 (IFP Imidazolate Framework Potsdam), is studied firstly by pure gas adsorption at 273 K. All experimental isotherms can be nicely described by using the Toth isotherm model and show the preferred adsorption of CO2 over CH4. At low pressures the Toth isotherm equation exhibits a Henry region, wherefore Henry's law constants for CO2 and CH4 uptake could be determined and ideal selectivity (alpha CO2/CH4) has been calculated. Secondly, selectivities were calculated from mixture data by using nearly equimolar binary mixtures of both gases by a volumetric-chromatographic method to examine the IFPs. Results showed the reliability of the selectivity calculation. Values of (alpha CO2/CH4) around 7.5 for IFP-5 indicate that this material shows much better selectivities than IFP-1, IFP-2, IFP-3, IFP-4 and IFP-6 with slightly lower selectivity (alpha CO2/CH4) = 4-6. The preferred adsorption of CO2 over CH4 especially of IFP-5 and IFP-4 makes these materials suitable for gas separation application.
Y1  - 2012
U6  - https://doi.org/10.1039/c2jm15811f
SN  - 0959-9428
VL  - 22
IS  - 20
SP  - 10221
EP  - 10227
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Trilcke, Peer
A1  - Parr, Rolf
A1  - D'Aprile, Iwan-Michelangelo
A1  - Kraus, Hans-Christof
A1  - Blomqvist, Clarissa
A1  - McGillen, Petra S.
A1  - Aus der Au, Carmen
A1  - Phillips, Alexander Robert
A1  - Helmer, Debora
A1  - Singer, Rüdiger
A1  - Görner, Rüdiger
A1  - Berbig, Roland
A1  - Rose, Dirk
A1  - Wilhelms, Kerstin
A1  - Krause, Marcus
A1  - Hehle, Christine
A1  - Gretz, Daniela
A1  - Gfrereis, Heike
A1  - Lepp, Nicola
A1  - Morlok, Franziska
A1  - Haut, Gideon
A1  - Brechenmacher, Thomas
A1  - Stauffer, Isabelle
A1  - Lyon, John B.
A1  - Bachmann, Vera
A1  - Ewert, Michael
A1  - Immer, Nikolas
A1  - Vedder, Ulrike
A1  - Fischer, Hubertus
A1  - Becker, Sabina
A1  - Wegmann, Christoph
A1  - Möller, Klaus-Peter
A1  - Schneider, Ulrike
A1  - Waszynski, Alexander
A1  - Wedel, Michael
A1  - Brehm, David
A1  - Wolpert, Georg
ED  - Trilcke, Peer
T1  - Fontanes Medien
T2  - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
N2  - Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen.
Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar.
T3  - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 178 
KW  - Fontane, Theodor
KW  - Gesellschaft
KW  - Medialisierung
KW  - Presse
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-574079
SN  - 1866-8380
IS  - 178
ER  - 
TY  - CHAP
A1  - Trilcke, Peer
A1  - Parr, Rolf
A1  - D'Aprile, Iwan-Michelangelo
A1  - Kraus, Hans-Christof
A1  - Blomqvist, Clarissa
A1  - McGillen, Petra S.
A1  - Aus der Au, Carmen
A1  - Phillips, Alexander Robert
A1  - Helmer, Debora
A1  - Singer, Rüdiger
A1  - Görner, Rüdiger
A1  - Berbig, Roland
A1  - Rose, Dirk
A1  - Wilhelms, Kerstin
A1  - Krause, Marcus
A1  - Hehle, Christine
A1  - Gretz, Daniela
A1  - Gfrereis, Heike
A1  - Lepp, Nicola
A1  - Morlok, Franziska
A1  - Haut, Gideon
A1  - Brechenmacher, Thomas
A1  - Stauffer, Isabelle
A1  - Lyon, John B.
A1  - Bachmann, Vera
A1  - Ewert, Michael
A1  - Immer, Nikolas
A1  - Vedder, Ulrike
A1  - Fischer, Hubertus
A1  - Becker, Sabina
A1  - Wegmann, Christoph
A1  - Möller, Klaus-Peter
A1  - Schneider, Ulrike
A1  - Waszynski, Alexander
A1  - Wedel, Michael
A1  - Brehm, David
A1  - Wolpert, Georg
ED  - Trilcke, Peer
T1  - Fontanes Medien
N2  - Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen.
Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar.
KW  - Fontane, Theodor
KW  - Gesellschaft
KW  - Medialisierung
KW  - Presse
Y1  - 2022
SN  - 978-3-11-073330-3
SN  - 978-3-11-073810-0
SN  - 978-3-11-073323-5
U6  - https://doi.org/10.1515/9783110733235
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Vorburger, Thomas
A1  - Nedielkov, Ruslan
A1  - Brosig, Alexander
A1  - Bok, Eva
A1  - Schunke, Emina
A1  - Steffen, Wojtek
A1  - Mayer, Sonja
A1  - Goetz, Friedrich
A1  - Möller, Heiko Michael
A1  - Steuber, Julia
T1  - Role of the Na+-translocating NADH:quinone oxidoreductase in voltage generation and Na+ extrusion in Vibrio cholerae
JF  - Biochimica et biophysica acta : Bioenergetics
N2  - For Vibrio cholerae, the coordinated import and export of Na+ is crucial for adaptation to habitats with different osmolarities. We investigated the Na+-extruding branch of the sodium cycle in this human pathogen by in vivo Na-23-NMR spectroscopy. The Na+ extrusion activity of cells was monitored after adding glucose which stimulated respiration via the Na+-translocating NADH:quinone oxidoreductase (Na+-NQR). In a V. cholerae deletion mutant devoid of the Na+-NQR encoding genes (nqrA-F), rates of respiratory Na+ extrusion were decreased by a factor of four, but the cytoplasmic Na+ concentration was essentially unchanged. Furthermore, the mutant was impaired in formation of transmembrane voltage (Delta psi, inside negative) and did not grow under hypoosmotic conditions at pH 8.2 or above. This growth defect could be complemented by transformation with the plasmid encoded nqr operon. In an alkaline environment, Na+/H+ antiporters acidify the cytoplasm at the expense of the transmembrane voltage. It is proposed that, at alkaline pH and limiting Na+ concentrations, the Na+-NQR is crucial for generation of a transmembrane voltage to drive the import of H+ by electrogenic Na+/H+ antiporters. Our study provides the basis to understand the role of the Na+-NQR in pathogenicity of V. cholerae and other pathogens relying on this primary Na+ pump for respiration. (C) 2015 Elsevier B.V. All rights reserved.
KW  - Nuclear magnetic resonance (NMR)
KW  - Sodium transport
KW  - Vibrio cholerae
KW  - Respiration
KW  - Na+ homeostasis
KW  - Hypoosmotic stress
Y1  - 2016
U6  - https://doi.org/10.1016/j.bbabio.2015.12.010
SN  - 0005-2728
SN  - 0006-3002
VL  - 1857
SP  - 473
EP  - 482
PB  - Elsevier
CY  - Amsterdam
ER  -