TY  - JOUR
A1  - Haase, Andrea
A1  - Rott, Stephanie
A1  - Mantion, Alexandre
A1  - Graf, Philipp
A1  - Plendl, Johanna
A1  - Thünemann, Andreas F.
A1  - Meier, Wolfgang P.
A1  - Taubert, Andreas
A1  - Luch, Andreas
A1  - Reiser, Georg
T1  - Effects of silver nanoparticles on primary mixed neural cell cultures: Uptake, oxidative stress and acute calcium responses
JF  - Toxicological sciences
N2  - In the body, nanoparticles can be systemically distributed and then may affect secondary target organs, such as the central nervous system (CNS). Putative adverse effects on the CNS are rarely investigated to date. Here, we used a mixed primary cell model consisting mainly of neurons and astrocytes and a minor proportion of oligodendrocytes to analyze the effects of well-characterized 20 and 40 nm silver nanoparticles (SNP). Similar gold nanoparticles served as control and proved inert for all endpoints tested. SNP induced a strong size-dependent cytotoxicity. Additionally, in the low concentration range (up to 10 mu g/ml of SNP), the further differentiated cultures were more sensitive to SNP treatment. For detailed studies, we used low/medium dose concentrations (up to 20 mu g/ml) and found strong oxidative stress responses. Reactive oxygen species (ROS) were detected along with the formation of protein carbonyls and the induction of heme oxygenase-1. We observed an acute calcium response, which clearly preceded oxidative stress responses. ROS formation was reduced by antioxidants, whereas the calcium response could not be alleviated by antioxidants. Finally, we looked into the responses of neurons and astrocytes separately. Astrocytes were much more vulnerable to SNP treatment compared with neurons. Consistently, SNP were mainly taken up by astrocytes and not by neurons. Immunofluorescence studies of mixed cell cultures indicated stronger effects on astrocyte morphology. Altogether, we can demonstrate strong effects of SNP associated with calcium dysregulation and ROS formation in primary neural cells, which were detectable already at moderate dosages.
KW  - silver nanoparticles
KW  - neurons
KW  - oxidative stress
KW  - protein carbonyls
KW  - calcium
Y1  - 2012
U6  - https://doi.org/10.1093/toxsci/kfs003
SN  - 1096-6080
VL  - 126
IS  - 2
SP  - 457
EP  - 468
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Haase, Andrea
A1  - Arlinghaus, Heinrich F.
A1  - Tentschert, Jutta
A1  - Jungnickel, Harald
A1  - Graf, Philipp
A1  - Mantion, Alexandre
A1  - Draude, Felix
A1  - Galla, Sebastian
A1  - Plendl, Johanna
A1  - Goetz, Mario E.
A1  - Masic, Admir
A1  - Meier, Wolfgang P.
A1  - Thuenemann, Andreas F.
A1  - Taubert, Andreas
A1  - Luch, Andreas
T1  - Application of Laser Postionization Secondary Neutral Mass Spectrometry/Time-of-Flight Secondary Ion Mass Spectrometry in Nanotoxicology: Visualization of Nanosilver in Human Macrophages and Cellular Responses
JF  - ACS nano
N2  - Silver nanoparticles (SNP) are the subject of worldwide commercialization because of their antimicrobial effects. Yet only little data on their mode of action exist. Further, only few techniques allow for visualization and quantification of unlabeled nanoparticles inside cells. To study SNP of different sizes and coatings within human macrophages, we introduce a novel laser postionization secondary neutral mass spectrometry (Laser-SNMS) approach and prove this method superior to the widely applied confocal Raman and transmission electron microscopy. With time-of-flight secondary ion mass spectrometry (TOF-SIMS) we further demonstrate characteristic fingerprints in the lipid pattern of the cellular membrane indicative of oxidative stress and membrane fluidity changes. Increases of protein carbonyl and heme oxygenase-1 levels in treated cells confirm the presence of oxidative stress biochemically. Intriguingly, affected phagocytosis reveals as highly sensitive end point of SNP-mediated adversity In macrophages. The cellular responses monitored are. hierarchically linked, but follow individual kinetics and are partially reversible.
KW  - nanosilver
KW  - Laser-SNMS
KW  - TOF-SIMS
KW  - confocal Raman microscopy
KW  - oxidative stress
KW  - protein carbonyls
Y1  - 2011
U6  - https://doi.org/10.1021/nn200163w
SN  - 1936-0851
VL  - 5
IS  - 4
SP  - 3059
EP  - 3068
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Graf, Philipp
A1  - Mantion, Alexandre
A1  - Haase, Andrea
A1  - Thuenemann, Andreas F.
A1  - Masic, Admir
A1  - Meier, Wolfgang P.
A1  - Luch, Andreas
A1  - Taubert, Andreas
T1  - Silicification of peptide-coated silver nanoparticles-A biomimetic soft chemistry approach toward chiral hybrid core-shell materials
JF  - ACS nano
N2  - Silica and silver nanoparticles are relevant materials for new applications in optics, medicine, and analytical chemistry. We have previously reported the synthesis of pH responsive, peptide-templated, chiral silver nanoparticles. The current report shows that peptide-stabilized nanoparticles can easily be coated with a silica shell by exploiting the ability of the peptide coating to hydrolyze silica precursors such as TEOS or TMOS. The resulting silica layer protects the nanoparticles from chemical etching, allows their inclusion in other materials, and renders them biocompatible. Using electron and atomic force microscopy, we show that the silica shell thickness and the particle aggregation can be controlled simply by the reaction time. Small-angle X ray scattering confirms the Ag/peptide@silica core-shell structure. UV-vis and circular dichroism spectroscopy prove the conservation of the silver nanoparticle chirality upon silicification. Biological tests show that the biocompatibility in simple bacterial systems is significantly improved once a silica layer is deposited on the silver particles.
KW  - peptide-templated materials
KW  - silver nanoparticles
KW  - chiral nanoparticles
KW  - Ag/peptide@SiO(2) nanostructures
KW  - core-shell structures
Y1  - 2011
U6  - https://doi.org/10.1021/nn102969p
SN  - 1936-0851
VL  - 5
IS  - 2
SP  - 820
EP  - 833
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Mantion, Alexandre
A1  - Graf, Philipp
A1  - Florea, Ileana
A1  - Haase, Andrea
A1  - Thuenemann, Andreas F.
A1  - Masic, Admir
A1  - Ersen, Ovidiu
A1  - Rabu, Pierre
A1  - Meier, Wolfgang P.
A1  - Luch, Andreas
A1  - Taubert, Andreas
T1  - Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN)
JF  - Nanoscale
N2  - Peptide-modified silver nanoparticles have been coated with an erbium-doped silica layer using a method inspired by silica biomineralization. Electron microscopy and small-angle X-ray scattering confirm the presence of an Ag/peptide core and silica shell. The erbium is present as small Er(2)O(3) particles in and on the silica shell. Raman, IR, UV-Vis, and circular dichroism spectroscopies show that the peptide is still present after shell formation and the nanoparticles conserve a chiral plasmon resonance. Magnetic measurements find a paramagnetic behavior. In vitro tests using a macrophage cell line model show that the resulting multicomponent nanoparticles have a low toxicity for macrophages, even on partial dissolution of the silica shell.
Y1  - 2011
U6  - https://doi.org/10.1039/c1nr10930h
SN  - 2040-3364
VL  - 3
IS  - 12
SP  - 5168
EP  - 5179
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Ihlenburg, Ramona
A1  - Mai, Tobias
A1  - Thünemann, Andreas F.
A1  - Baerenwald, Ruth
A1  - Saalwächter, Kay
A1  - Koetz, Joachim
A1  - Taubert, Andreas
T1  - Sulfobetaine hydrogels with a complex multilength-scale hierarchical structure
JF  - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry
N2  - Hydrogels with a hierarchical structure were prepared from a new highly water-soluble crosslinker N,N,N',N'-tetramethyl-N,N'-bis(2-ethylmethacrylate)-propyl-1,3-diammonium dibromide and from the sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate. The free radical polymerization of the two compounds is rapid and yields near-transparent hydrogels with sizes up to 5 cm in diameter. Rheology shows a clear correlation between the monomer-to-crosslinker ratio and the storage and loss moduli of the hydrogels. Cryo-scanning electron microscopy, low-field nuclear magnetic resonance (NMR) spectroscopy, and small-angle X-ray scattering show that the gels have a hierarchical structure with features spanning the nanometer to the sub-millimeter scale. The NMR study is challenged by the marked inhomogeneity of the gels and the complex chemical structure of the sulfobetaine monomer. NMR spectroscopy shows how these complications can be addressed via a novel fitting approach that considers the mobility gradient along the side chain of methacrylate-based monomers.
KW  - Defects
KW  - Hydrogels
KW  - Nuclear magnetic resonance spectroscopy
KW  - Scattering
KW  - X-ray scattering
Y1  - 2021
U6  - https://doi.org/10.1021/acs.jpcb.0c10601
SN  - 1520-6106
SN  - 1520-5207
VL  - 125
IS  - 13
SP  - 3398
EP  - 3408
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Draude, F.
A1  - Galla, S.
A1  - Pelster, Axel
A1  - Tentschert, J.
A1  - Jungnickel, H.
A1  - Haase, Alfred
A1  - Mantion, Alexandre
A1  - Thuenemann, Andreas F.
A1  - Taubert, Andreas
A1  - Luch, A.
A1  - Arlinghaus, H. F.
T1  - ToF-SIMS and Laser-SNMS analysis of macrophages after exposure to silver nanoparticles
JF  - Surface and interface analysis : an international journal devoted to the development and application of techniques for the analysis surfaces, interfaces and thin films
N2  - Silver nanoparticles (SNPs) are among the most commercialized nanoparticles because of their antibacterial effects. Besides being employed, e. g. as a coatingmaterial for sterile surfaces in household articles and appliances, the particles are also used in a broad range of medical applications. Their antibacterial properties make SNPs especially useful for wound disinfection or as a coating material for prostheses and surgical instruments. Because of their optical characteristics, the particles are of increasing interest in biodetection as well. Despite the widespread use of SNPs, there is little knowledge of their toxicity. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and laser post-ionization secondary neutral mass spectrometry (Laser-SNMS) were used to investigate the effects of SNPs on human macrophages derived from THP-1 cells in vitro. For this purpose, macrophages were exposed to SNPs. The SNP concentration ranges were chosen with regard to functional impairments of the macrophages. To optimize the analysis of the macrophages, a special silicon wafer sandwich preparation technique was employed; ToF-SIMS was employed to characterize fragments originating from macrophage cell membranes. With the use of this optimized sample preparation method, the SNP-exposed macrophages were analyzed with ToF-SIMS and with Laser-SNMS. With Laser-SNMS, the three-dimensional distribution of SNPs in cells could be readily detected with very high efficiency, sensitivity, and submicron lateral resolution. We found an accumulation of SNPs directly beneath the cell membrane in a nanoparticular state as well as agglomerations of SNPs inside the cells.
KW  - Laser-SNMS
KW  - ToF-SIMS
KW  - life sciences
KW  - imaging
KW  - nanoparticles
KW  - three-dimensional depth profiling
Y1  - 2013
U6  - https://doi.org/10.1002/sia.4902
SN  - 0142-2421
VL  - 45
IS  - 1
SP  - 286
EP  - 289
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Graf, Philipp
A1  - Mantion, Alexandre
A1  - Foelske, Annette
A1  - Shkilnyy, Andriy
A1  - MaÜic, Admir
A1  - Thuenemann, Andreas F.
A1  - Taubert, Andreas
T1  - Peptide-coated silver nanoparticles : synthesis, surface chemistry, and pH-triggered, reversible assembly into particle assemblies
N2  - Simple tripeptides are scaffolds for the synthesis and further assembly of peptide/silver nanoparticle composites. Herein, we further explore peptide-con trolled silver nanoparticle assembly processes. Silver nanoparticles with a pH-responsive peptide coating have been synthesized by using a one-step precipitation/coating route. The nature of the peptide/silver interaction and the effect of the peptide oil the formation of the silver particles have been studied via UV/Vis, X-ray photoelectron, and surface-enhanced Raman spectroscopies as well as through electron microscopy, small angle X-ray scattering and powder Xray diffraction with Rietveld refinement. The particles reversibly form aggregates of different sizes in aqueous solution. The state of aggregation call be controlled by the solution pH value. At low pH values, individual particles are present. At neutral pH values, small clusters form and at high pH values, large precipitates are observed.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/cgi-bin/jhome/26293/
U6  - https://doi.org/10.1002/chem.200802329
SN  - 0947-6539
ER  - 
TY  - JOUR
A1  - Haase, A.
A1  - Mantion, A.
A1  - Graf, P.
A1  - Plendl, J.
A1  - Thünemann, Andreas F.
A1  - Meier, Wolfgang P.
A1  - Taubert, Andreas
A1  - Luch, A.
T1  - A novel type of silver nanoparticles and their advantages in toxicity testing in cell culture systems
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Silver nanoparticles (SNPs) are among the most commercialized nanoparticles worldwide. Often SNP are used because of their antibacterial properties. Besides that they possess unique optic and catalytic features, making them highly interesting for the creation of novel and advanced functional materials. Despite its widespread use only little data exist in terms of possible adverse effects of SNP on human health. Conventional synthesis routes usually yield products of varying quality and property. It thus may become puzzling to compare biological data from different studies due to the great variety in sizes, coatings or shapes of the particles applied. Here, we applied a novel synthesis approach to obtain SNP of well-defined colloidal and structural properties. Being stabilized by a covalently linked small peptide, these particles are nicely homogenous, with narrow size distribution, and form monodisperse suspensions in aqueous solutions. We applied these peptide-coated SNP in two different sizes of 20 or 40 nm (Ag20Pep and Ag40Pep) and analyzed responses of THP-1-derived human macrophages while being exposed against these particles. Gold nanoparticles of similar size and coating (Au20Pep) were used for comparison. The cytotoxicity of particles was assessed by WST-1 and LDH assays, and the uptake into the cells was confirmed via transmission electron microscopy. In summary, our data demonstrate that this novel type of SNP is well suited to serve as model system for nanoparticles to be tested in toxicological studies in vitro.
KW  - Silver nanoparticles
KW  - Peptide coating
KW  - Nanotoxicity
Y1  - 2012
U6  - https://doi.org/10.1007/s00204-012-0836-0
SN  - 0340-5761
VL  - 86
IS  - 7
SP  - 1089
EP  - 1098
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Tentschert, J.
A1  - Draude, F.
A1  - Jungnickel, H.
A1  - Haase, A.
A1  - Mantion, Alexandre
A1  - Galla, S.
A1  - Thuenemann, Andreas F.
A1  - Taubert, Andreas
A1  - Luch, A.
A1  - Arlinghaus, H. F.
T1  - TOF-SIMS analysis of cell membrane changes in functional impaired human macrophages upon nanosilver treatment
JF  - Surface and interface analysis : an international journal devoted to the development and application of techniques for the analysis surfaces, interfaces and thin films
N2  - Silver nanoparticles (SNP) are among the most commercialized nanoparticles. Here, we show that peptide-coated SNP cause functional impairment of human macrophages. A dose-dependent inhibition of phagocytosis is observed after nanoparticle treatment, and pretreatment of cells with N-acetyl cysteine (NAC) can counteract the phagocytosis disturbances caused by SNP.
 Using the surface-sensitive mode of time-of-flight secondary ion mass spectrometry, in combination with multivariate statistical methods, we studied the composition of cell membranes in human macrophages upon exposure to SNP with and without NAC preconditioning. This method revealed characteristic changes in the lipid pattern of the cellular membrane outer leaflet in those cells challenged by SNP. Statistical analyses resulted in 19 characteristic ions, which can be used to distinguish between NAC pretreated and untreated macrophages. The present study discusses the assignments of surface cell membrane phospholipids for the identified ions and the resulting changes in the phospholipid pattern of treated cells. We conclude that the adverse effects in human macrophages caused by SNP can be partially reversed through NAC administration. Some alterations, however, remained.
KW  - silver nanoparticles
KW  - lipidomics
KW  - N-acetyl cysteine
KW  - phagocytosis
KW  - oxidative stress
Y1  - 2013
U6  - https://doi.org/10.1002/sia.5155
SN  - 0142-2421
VL  - 45
IS  - 1
SP  - 483
EP  - 485
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Casse, Olivier
A1  - Shkilnyy, Andriy
A1  - Linders, Jürgen
A1  - Mayer, Christian
A1  - Häussinger, Daniel
A1  - Völkel, Antje
A1  - Thünemann, Andreas F.
A1  - Dimova, Rumiana
A1  - Cölfen, Helmut
A1  - Meier, Wolfgang P.
A1  - Schlaad, Helmut
A1  - Taubert, Andreas
T1  - Solution behavior of double-hydrophilic block copolymers in dilute aqueous solution
JF  - Macromolecules : a publication of the American Chemical Society
N2  - The self-assembly of double-hydrophilic poly(ethylene oxide)-poly(2-methyl-2-oxazoline) diblock copolymers in water has been studied. Isothermal titration calorimetry, small-angle X-ray scattering, and analytical ultracentrifugation suggest that only single polymer chains are present in solution. In contrast, light scattering and transmission electron microscopy detect aggregates with radii of ca. 100 nm. Pulsed field gradient NMR spectroscopy confirms the presence of aggregates, although only 2% of the polymer chains undergo aggregation. Water uptake experiments indicate differences in the hydrophilicity of the two blocks, which is believed to be the origin of the unexpected aggregation behavior (in accordance with an earlier study by Ke et al. [Macromolecules 2009, 42, 5339-5344]). The data therefore suggest that even in double-hydrophilic block copolymers, differences in hydrophilicity are sufficient to drive polymer aggregation, a phenomenon that has largely been overlooked or ignored so far.
Y1  - 2012
U6  - https://doi.org/10.1021/ma300621g
SN  - 0024-9297
VL  - 45
IS  - 11
SP  - 4772
EP  - 4777
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Farra, Ramzi
A1  - Thiel, Kerstin
A1  - Winter, Alette
A1  - Klamroth, Tillmann
A1  - Poeppl, Andreas
A1  - Kelling, Alexandra
A1  - Schilde, Uwe
A1  - Taubert, Andreas
A1  - Strauch, Peter
T1  - Tetrahalidocuprates(II)-structure and EPR spectroscopy Part 1: Tetrabromidocuprates(II)
JF  - New journal of chemistry
N2  - Tetrahalidocuprates(II) show a high degree of structural flexibility. We present the results of crystallographic and electron paramagnetic resonance (EPR) spectroscopic analyses of four new tetrabromidocuprate(II) compounds and compare the results with previously reported data. The cations in the new compounds are the sterically demanding benzyltriphenylphosphonium, methyltriphenylphosphonium, tetraphenylphosphonium, and hexadecyltrimethylammonium ions; they were used to achieve a reasonable separation of the paramagnetic Cu(II) ions for EPR spectroscopy. X-Ray crystallography shows that in all four complexes the [CuBr4](2-) units have a distorted tetrahedral coordination geometry which is in agreement with DFT calculations. The EPR hyperfine structure was not resolved. This is due to the exchange broadening resulting from still incomplete separation of the paramagnetic Cu(II) centres. Nevertheless, the principal values of the electron Zeemann tensor (g(parallel to) and g(perpendicular to)) of the complexes could be determined. A correlation of structural (X-ray) parameters with the spin density at the copper centres (DFT) is well reflected in the EPR spectra of the bromidocuprates. This enables the correlation of X-ray and EPR parameters to predict the structure of tetrabromidocuprates in physical states other than the crystalline state. As a result, we provide a method to structurally characterize [CuBr4](2-) in, for example, ionic liquids or in solution, which has important implications for e.g. catalysis or materials science.
Y1  - 2011
U6  - https://doi.org/10.1039/c1nj20271e
SN  - 1144-0546
VL  - 35
IS  - 12
SP  - 2793
EP  - 2803
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Winter, Alette
A1  - Thiel, Kerstin
A1  - Zabel, Andre
A1  - Klamroth, Tillmann
A1  - Poeppl, Andreas
A1  - Kelling, Alexandra
A1  - Schilde, Uwe
A1  - Taubert, Andreas
A1  - Strauch, Peter
T1  - Tetrahalidocuprates(II) - structure and EPR spectroscopy. Part 2: tetrachloridocuprates(II)
JF  - New journal of chemistry
N2  - We present and discuss the results of crystallographic and electron paramagnetic resonance (EPR) spectroscopic analyses of five tetrachloridocuprate(II) complexes to supply a useful tool for the structural characterisation of the [CuCl4](2-) moiety in the liquid state, for example in ionic liquids, or in solution. Bis(benzyltriethylammonium)-, bis(trimethylphenylammonium)-, bis(ethyltriphenylphosphonium)-, bis(benzyltriphenylphosphonium)-, and bis(tetraphenylarsonium) tetrachloridocuprate(II) were synthesised and characterised by elemental, IR, EPR and X-ray analyses. The results of the crystallographic analyses show distorted tetrahedral coordination geometry of all [CuCl4](2-) anions in the five complexes and prove that all investigated complexes are stabilised by hydrogen bonds of different intensities. Despite the use of sterically demanding ammonium, phosphonium and arsonium cations to obtain the separation of the paramagnetic Cu(II) centres for EPR spectroscopy no hyperfine structure was observed in the EPR spectra but the principal values of the electron Zeeman tensor, g(parallel to) and g(perpendicular to), could be determined. With these EPR data and the crystallographic parameters we were able to carry out a correlation study to anticipate the structural situation of tetrachloridocuprates in different physical states. This correlation is in good agreement with DFT calculations.
Y1  - 2014
U6  - https://doi.org/10.1039/c3nj01039b
SN  - 1144-0546
SN  - 1369-9261
VL  - 38
IS  - 3
SP  - 1019
EP  - 1030
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Lutze, Jana
A1  - Bañares, Miguel A.
A1  - Pita, Marcos
A1  - Haase, Andrea
A1  - Luch, Andreas
A1  - Taubert, Andreas
T1  - alpha-((4-Cyanobenzoyl)oxy)-omega-methyl poly(ethylene glycol)
BT  - a new stabilizer for silver nanoparticles
JF  - Beilstein journal of nanotechnology
N2  - The article describes the synthesis and properties of alpha-((4-cyanobenzoyl)oxy)-omega-methyl poly(ethylene glycol), the first poly(ethylene glycol) stabilizer for metal nanoparticles that is based on a cyano rather than a thiol or thiolate anchor group. The silver particles used to evaluate the effectiveness of the new stabilizer typically have a bimodal size distribution with hydrodynamic diameters of ca. 13 and ca. 79 nm. Polymer stability was evaluated as a function of the pH value both for the free stabilizer and for the polymers bound to the surface of the silver nanoparticles using H-1 NMR spectroscopy and zeta potential measurements. The polymer shows a high stability between pH 3 and 9. At pH 12 and higher the polymer coating is degraded over time suggesting that alpha-((4-cyanobenzoyl) oxy)-omega-methyl poly(ethylene glycol) is a good stabilizer for metal nanoparticles in aqueous media unless very high pH conditions are present in the system. The study thus demonstrates that cyano groups can be viable alternatives to the more conventional thiol/thiolate anchors.
KW  - cyano anchor group
KW  - poly(ethylene glycol)
KW  - polymer coating
KW  - silver nanoparticles
Y1  - 2017
U6  - https://doi.org/10.3762/bjnano.8.67
SN  - 2190-4286
VL  - 8
SP  - 627
EP  - 635
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  - 
TY  - GEN
A1  - Winter, Alette
A1  - Thiel, Kerstin
A1  - Zabel, André
A1  - Klamroth, Tillmann
A1  - Pöppl, Andreas
A1  - Kelling, Alexandra
A1  - Schilde, Uwe
A1  - Taubert, Andreas
A1  - Strauch, Peter
T1  - Tetrahalidocuprates(II) – structure and EPR spectroscopy
BT  - Part 2: tetrachloridocuprates(II)
N2  - We present and discuss the results of crystallographic and electron paramagnetic resonance (EPR) spectroscopic analyses of five tetrachloridocuprate(II) complexes to supply a useful tool for the structural characterisation of the [CuCl4]2− moiety in the liquid state, for example in ionic liquids, or in solution. Bis(benzyltriethylammonium)-, bis(trimethylphenylammonium)-, bis(ethyltriphenylphosphonium)-, bis(benzyltriphenylphosphonium)-, and bis(tetraphenylarsonium)tetrachloridocuprate(II) were synthesised and characterised by elemental, IR, EPR and X-ray analyses. The results of the crystallographic analyses show distorted tetrahedral coordination geometry of all [CuCl4]2− anions in the five complexes and prove that all investigated complexes are stabilised by hydrogen bonds of different intensities. Despite the use of sterically demanding ammonium, phosphonium and arsonium cations to obtain the separation of the paramagnetic Cu(II) centres for EPR spectroscopy no hyperfine structure was observed in the EPR spectra but the principal values of the electron Zeeman tensor, g∥ and g⊥, could be determined. With these EPR data and the crystallographic parameters we were able to carry out a correlation study to anticipate the structural situation of tetrachloridocuprates in different physical states. This correlation is in good agreement with DFT calculations.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 240 
KW  - electron-spin resonance
KW  - liquid-crystal precursors
KW  - copper(II) halide salts
KW  - ionic liquid
KW  - square planar
KW  - tetrachlorocuprate(II) salts
KW  - molecular-structure
KW  - magnetic-properties
KW  - paramagnetic-resonance
KW  - temperature phase
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95012
SP  - 1019
EP  - 1030
ER  - 
TY  - JOUR
A1  - Delahaye, Emilie
A1  - Xie, Zailai
A1  - Schäfer, Andreas
A1  - Douce, Laurent
A1  - Rogez, Guillaume
A1  - Rabu, Pierre
A1  - Günter, Christina
A1  - Gutmann, Jochen S.
A1  - Taubert, Andreas
T1  - Intercalation synthesis of functional hybrid materials based on layered simple hydroxide hosts and ionic liquid guests - a pathway towards multifunctional ionogels without a silica matrix?
JF  - Dalton transactions : a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry
N2  - Functional hybrid materials on the basis of inorganic hosts and ionic liquids (ILs) as guests hold promise for a virtually unlimited number of applications. In particular, the interaction and the combination of properties of a defined inorganic matrix and a specific IL could lead to synergistic effects in property selection and tuning. Such hybrid materials, generally termed ionogels, are thus an emerging topic in hybrid materials research. The current article addresses some of the recent developments and focuses on the question why silica is currently the dominating matrix used for (inorganic) ionogel fabrication. In comparison to silica, matrix materials such as layered simple hydroxides, layered double hydroxides, clay-type substances, magnetic or catalytically active solids, and many other compounds could be much more interesting because they themselves may carry useful functionalities, which could also be exploited for multifunctional hybrid materials synthesis. The current article combines experimental results with some arguments as to how new, advanced functional hybrid materials can be generated and which obstacles will need to be overcome to successfully achieve the synthesis of a desired target material.
Y1  - 2011
U6  - https://doi.org/10.1039/c1dt10841g
SN  - 1477-9226
VL  - 40
IS  - 39
SP  - 9977
EP  - 9988
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Kita-Tokarczyk, Katarzyna
A1  - Junginger, Mathias
A1  - Belegrinou, Serena
A1  - Taubert, Andreas
ED  - Muller, AHE
ED  - Borisov, O
T1  - Amphiphilic polymers at interfaces
JF  - Advances in polymer science
JF  - Advances in Polymer Science
N2  - Self-assembly phenomena in block copolymer systems are attracting considerable interest from the scientific community and industry alike. Particularly interesting is the behavior of amphiphilic copolymers, which can self-organize into nanoscale-sized objects such as micelles, vesicles, or tubes in solution, and which form well-defined assemblies at interfaces such as air-liquid, air-solid, or liquid-solid. Depending on the polymer chemistry and architecture, various types of organization at interfaces can be expected, and further exploited for applications in nanotechnology, electronics, and biomedical sciences.
 In this article, we discuss the formation and characterization of Langmuir monolayers from various amphiphilic block copolymers, including chargeable and thus pH-responsivematerials. Solid-supported polymer films are reviewed in the context of alteration of surface properties by ultrathin polymer layers and the possibilities for application in tissue engineering, sensors and biomaterials. Finally, we focus on how organic and polymer monolayers influence the growth of inorganic materials. This is a truly biomimetic approach since Nature uses soft interfaces to control the nucleation, growth, and morphology of biominerals such as calcium phosphate, calcium carbonate, and silica.
KW  - Amphiphilic polymers
KW  - Langmuir monolayers
KW  - Polymers on surfaces
KW  - Bio-inspired mineralization
Y1  - 2011
SN  - 978-3-642-22297-9
U6  - https://doi.org/10.1007/12_2010_58
SN  - 0065-3195
VL  - 242
IS  - 1
SP  - 151
EP  - 201
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Shkilnyy, Andriy
A1  - Gräf, Ralph
A1  - Hiebl, Bernhard
A1  - Neffe, Axel T.
A1  - Friedrich, Alwin
A1  - Hartmann, Juergen
A1  - Taubert, Andreas
T1  - Unprecedented, low cytotoxicity of spongelike calcium phosphate/poly(ethylene imine) hydrogel composites
N2  - Covalently crosslinked PEI hydrogels are efficient templates for calcium phosphate mineralization in SBF. In contrast to the PEI hydrogels, non-crosslinked PEI does not lead to calcium phosphate nucleation and growth in SBF. The precipitate is a mixture of brushite and hydroxyapatite. The PEI/calcium phosphate composite material exhibits a sponge like morphology and a chemical composition that is interesting for implants. Cytotoxicity tests using Dictyostelium discoideum amoebae show that both the non-mineralized and mineralized hydrogels have a very low cytotoxicity. This suggests that next generation PEI hydrogels, where also the degradation products are non-toxic, could be interesting for biomedical applications.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/cgi-bin/jhome/77002860
U6  - https://doi.org/10.1002/mabi.200800266
SN  - 1616-5187
ER  - 
TY  - JOUR
A1  - Ihlenburg, Ramona
A1  - Lehnen, Anne-Catherine
A1  - Koetz, Joachim
A1  - Taubert, Andreas
T1  - Sulfobetaine Cryogels for Preferential Adsorption of Methyl Orange from Mixed Dye Solutions
JF  - Polymers / Molecular Diversity Preservation International
N2  - New cryogels for selective dye removal from aqueous solution were prepared by free radical polymerization from the highly water-soluble crosslinker N,N,N’,N’-tetramethyl-N,N’-bis(2-ethylmethacrylate)-propyl-1,3-diammonium dibromide and the sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate. The resulting white and opaque cryogels have micrometer sized pores with a smaller substructure. They adsorb methyl orange (MO) but not methylene blue (MB) from aqueous solution. Mixtures of MO and MB can be separated through selective adsorption of the MO to the cryogels while the MB remains in solution. The resulting cryogels are thus candidates for the removal of hazardous organic substances, as exemplified by MO and MB, from water. Clearly, it is possible that the cryogels are also potentially interesting for removal of other compounds such as pharmaceuticals or pesticides, but this must be investigated further.
KW  - cryogel
KW  - water treatment
KW  - dye removal
KW  - methyl orange
KW  - methylene blue
KW  - dye mixture
Y1  - 2020
U6  - https://doi.org/10.3390/polym13020208
SN  - 2073-4360
VL  - 13
IS  - 2
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Ihlenburg, Ramona
A1  - Lehnen, Anne-Catherine
A1  - Koetz, Joachim
A1  - Taubert, Andreas
T1  - Sulfobetaine Cryogels for Preferential Adsorption of Methyl Orange from Mixed Dye Solutions
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - New cryogels for selective dye removal from aqueous solution were prepared by free radical polymerization from the highly water-soluble crosslinker N,N,N’,N’-tetramethyl-N,N’-bis(2-ethylmethacrylate)-propyl-1,3-diammonium dibromide and the sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate. The resulting white and opaque cryogels have micrometer sized pores with a smaller substructure. They adsorb methyl orange (MO) but not methylene blue (MB) from aqueous solution. Mixtures of MO and MB can be separated through selective adsorption of the MO to the cryogels while the MB remains in solution. The resulting cryogels are thus candidates for the removal of hazardous organic substances, as exemplified by MO and MB, from water. Clearly, it is possible that the cryogels are also potentially interesting for removal of other compounds such as pharmaceuticals or pesticides, but this must be investigated further.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1093 
KW  - cryogel
KW  - water treatment
KW  - dye removal
KW  - methyl orange
KW  - methylene blue
KW  - dye mixture
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-488987
SN  - 1866-8372
IS  - 1093
ER  - 
TY  - JOUR
A1  - Lehmann, Frederike
A1  - Franz, Alexandra
A1  - Toebbens, Daniel M.
A1  - Levcenco, Sergej
A1  - Unold, Thomas
A1  - Taubert, Andreas
A1  - Schorr, Susan
T1  - The phase diagram of a mixed halide (Br, I) hybrid perovskite obtained by synchrotron X-ray diffraction
JF  - RSC Advances
N2  - By using synchrotron X-ray powder diffraction, the temperature dependent phase diagram of the hybrid perovskite tri-halide compounds, methyl ammonium lead iodide (MAPbI3, MA+ = CH3NH3+) and methyl ammonium lead bromide (MAPbBr3), as well as of their solid solutions, has been established. The existence of a large miscibility gap between 0.29 ≤ x ≤ 0.92 (±0.02) for the MAPb(I1−xBrx)3 solid solution has been proven. A systematic study of the lattice parameters for the solid solution series at room temperature revealed distinct deviations from Vegard's law. Furthermore, temperature dependent measurements showed that a strong temperature dependency of lattice parameters from the composition is present for iodine rich compositions. In contrast, the bromine rich compositions show an unusually low dependency of the phase transition temperature from the degree of substitution.
Y1  - 2019
U6  - https://doi.org/10.1039/c8ra09398a
SN  - 2046-2069
VL  - 9
IS  - 20
SP  - 11151
EP  - 11159
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -