TY  - JOUR
A1  - Tass, Peter
A1  - Rosenblum, Michael
A1  - Weule, J.
A1  - Kurths, Jürgen
A1  - Pikovskij, Arkadij
A1  - Volkmann, J.
A1  - Schnitzler, A.
A1  - Freund, H.-J.
T1  - Detection of n:m phase locking from noisy data : application to magnetoencephalography
N2  - We use the concept of phase synchronization for the analysis of noisy nonstationary bivariate data. Phase synchronization is understood in a statistical sense as an existence of preferred values of the phase difference, and two techniques are proposed for a reliable detection of synchronous epochs. These methods are applied to magnetoencephalograms and records of muscle activity of a Parkinsonian patient. We reveal that
Y1  - 1998
ER  - 
TY  - JOUR
A1  - Popovych, Oleksandr V.
A1  - Lysyansky, Borys
A1  - Rosenblum, Michael
A1  - Pikovskij, Arkadij
A1  - Tass, Peter A.
T1  - Pulsatile desynchronizing delayed feedback for closed-loop deep brain stimulation
JF  - PLoS one
N2  - High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of medically refractory movement disorders like Parkinson’s disease, essential tremor, and dystonia, with a significant potential for application to other neurological diseases. The standard setup of HF DBS utilizes an open-loop stimulation protocol, where a permanent HF electrical pulse train is administered to the brain target areas irrespectively of the ongoing neuronal dynamics. Recent experimental and clinical studies demonstrate that a closed-loop, adaptive DBS might be superior to the open-loop setup. We here combine the notion of the adaptive high-frequency stimulation approach, that aims at delivering stimulation adapted to the extent of appropriately detected biomarkers, with specifically desynchronizing stimulation protocols. To this end, we extend the delayed feedback stimulation methods, which are intrinsically closed-loop techniques and specifically designed to desynchronize abnormal neuronal synchronization, to pulsatile electrical brain stimulation. We show that permanent pulsatile high-frequency stimulation subjected to an amplitude modulation by linear or nonlinear delayed feedback methods can effectively and robustly desynchronize a STN-GPe network of model neurons and suggest this approach for desynchronizing closed-loop DBS.
Y1  - 2017
U6  - https://doi.org/10.1371/journal.pone.0173363
SN  - 1932-6203
VL  - 12
PB  - PLoS
CY  - San Fransisco
ER  -