TY  - JOUR
A1  - Czech, Andreas
A1  - Wende, Sandra
A1  - Moerl, Mario
A1  - Pan, Tao
A1  - Ignatova, Zoya
T1  - Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress
JF  - PLoS Genetics : a peer-reviewed, open-access journal
N2  - Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels. In this study, we demonstrate that exposure to oxidative stress results in a quick repression of translation by deactivation of the aminoacylends of all transfer-RNA (tRNA). An oxidative-stress activated nuclease, angiogenin, cleaves first within the conserved single-stranded 3'-CCA termini of all tRNAs, thereby blocking their use in translation. This CCA deactivation is reversible and quickly repairable by the CCA-adding enzyme [ATP(CTP): tRNA nucleotidyltransferase]. Through this mechanism the eukaryotic cell dynamically represses and reactivates translation at low metabolic costs.
Y1  - 2013
U6  - https://doi.org/10.1371/journal.pgen.1003767
SN  - 1553-7404
VL  - 9
IS  - 8
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Hu, Ting-Li
A1  - Cheng, Feng
A1  - Xu, Zhen
A1  - Chen, Zhong-Zheng
A1  - Yu, Lei
A1  - Ban, Qian
A1  - Li, Chun-Lin
A1  - Pan, Tao
A1  - Zhang, Bao-Wei
T1  - Molecular and morphological evidence for a new species of the genus Typhlomys (Rodentia: Platacanthomyidae)
JF  - Zoological research : ZR = Dongwuxue-yanjiu : jikan / published by Kunming Institute of Zoology, Chinese Academy of Sciences, Zhongguo Kexueyuan Kunming Dongwu Yanjiusuo zhuban, Dongwuxue-yanjiu Bianji Weiyuanhui bianji
N2  - In this study, we reassessed the taxonomic position of Typhlomys (Rodentia: Platacanthomyidae) from Huangshan, Anhui, China, based on morphological and molecular evidence. Results suggested that Typhlomys is comprised of up to six species, including four currently recognized species ( Typhlomys cinereus, T. chapensis, T. daloushanensis, and T. nanus), one unconfirmed candidate species, and one new species ( Typhlomys huangshanensis sp. nov.). Morphological analyses further supported the designation of the Huangshan specimens found at mid-elevations in the southern Huangshan Mountains (600 m to 1 200 m a.s.l.) as a new species.
KW  - Morphology
KW  - Phylogenetics
KW  - Species delimitation
KW  - Taxonomy
Y1  - 2021
U6  - https://doi.org/10.24272/j.issn.2095-8137.2020.132
SN  - 2095-8137
VL  - 42
IS  - 1
SP  - 100
EP  - 107
PB  - Yunnan Renmin Chubanshe
CY  - Kunming
ER  -