TY - JOUR A1 - Tang, Alan T. A1 - Sullivan, Katie Rose A1 - Hong, Courtney C. A1 - Goddard, Lauren M. A1 - Mahadevan, Aparna A1 - Ren, Aileen A1 - Pardo, Heidy A1 - Peiper, Amy A1 - Griffin, Erin A1 - Tanes, Ceylan A1 - Mattei, Lisa M. A1 - Yang, Jisheng A1 - Li, Li A1 - Mericko-Ishizuka, Patricia A1 - Shen, Le A1 - Hobson, Nicholas A1 - Girard, Romuald A1 - Lightle, Rhonda A1 - Moore, Thomas A1 - Shenkar, Robert A1 - Polster, Sean P. A1 - Roedel, Claudia Jasmin A1 - Li, Ning A1 - Zhu, Qin A1 - Whitehead, Kevin J. A1 - Zheng, Xiangjian A1 - Akers, Amy A1 - Morrison, Leslie A1 - Kim, Helen A1 - Bittinger, Kyle A1 - Lengner, Christopher J. A1 - Schwaninger, Markus A1 - Velcich, Anna A1 - Augenlicht, Leonard A1 - Abdelilah-Seyfried, Salim A1 - Min, Wang A1 - Marchuk, Douglas A. A1 - Awad, Issam A. A1 - Kahn, Mark L. T1 - Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation JF - Science Translational Medicine N2 - Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in KRIT1, CCM2, or PDCD10. Disease onset is earlier and more severe in individuals with PDCD10 mutations. Recent studies have shown that lesions arise from excess mitogen-activated protein kinase kinase kinase 3 (MEKK3) signaling downstream of Toll-like receptor 4 (TLR4) stimulation by lipopolysaccharide derived from the gut microbiome. These findings suggest a gut-brain CCM disease axis but fail to define it or explain the poor prognosis of patients with PDCD10 mutations. Here, we demonstrate that the gut barrier is a primary determinant of CCM disease course, independent of microbiome configuration, that explains the increased severity of CCM disease associated with PDCD10 deficiency. Chemical disruption of the gut barrier with dextran sulfate sodium augments CCM formation in a mouse model, as does genetic loss of Pdcd10, but not Krit1, in gut epithelial cells. Loss of gut epithelial Pdcd10 results in disruption of the colonic mucosal barrier. Accordingly, loss of Mucin-2 or exposure to dietary emulsifiers that reduce the mucus barrier increases CCM burden analogous to loss of Pdcd10 in the gut epithelium. Last, we show that treatment with dexamethasone potently inhibits CCM formation in mice because of the combined effect of action at both brain endothelial cells and gut epithelial cells. These studies define a gut-brain disease axis in an experimental model of CCM in which a single gene is required for two critical components: gut epithelial function and brain endothelial signaling. Y1 - 2019 U6 - https://doi.org/10.1126/scitranslmed.aaw3521 SN - 1946-6234 SN - 1946-6242 VL - 11 IS - 520 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Ulyanenkov, A. A1 - Baumbach, Tilo A1 - Darowski, Nora A1 - Pietsch, Ullrich A1 - Wang, K. H. A1 - Forchel, Alfred A1 - Wiebach, T. T1 - Investigation of the in-plane strain distribution in free-standing GaAs/InGaAs/GaAs single quantum well surface nanostructures on GaAs[001] Y1 - 1999 ER - TY - JOUR A1 - Wang, Weiwei A1 - Naolou, Toufik A1 - Ma, Nan A1 - Deng, Zijun A1 - Xu, Xun A1 - Mansfeld, Ulrich A1 - Wischke, Christian A1 - Gossen, Manfred A1 - Neffe, Axel T. A1 - Lendlein, Andreas T1 - Polydepsipeptide Block-Stabilized Polyplexes for Efficient Transfection of Primary Human Cells JF - Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences N2 - The rational design of a polyplex gene carrier aims to balance maximal effectiveness of nucleic acid transfection into cells with minimal adverse effects. Depsipeptide blocks with an M (n) similar to 5 kDa exhibiting strong physical interactions were conjugated with PEI moieties (2.5 or 10 kDa) to di- and triblock copolymers. Upon nanoparticle formation and complexation with DNA, the resulting polyplexes (sizes typically 60-150 nm) showed remarkable stability compared to PEI-only or lipoplex and facilitated efficient gene delivery. Intracellular trafficking was visualized by observing fluorescence-labeled pDNA and highlighted the effective cytoplasmic uptake of polyplexes and release of DNA to the perinuclear space. Specifically, a triblock copolymer with a middle depsipeptide block and two 10 kDa PEI swallowtail structures mediated the highest levels of transgenic VEGF secretion in mesenchymal stem cells with low cytotoxicity. These nanocarriers form the basis for a delivery platform technology, especially for gene transfer to primary human cells. Y1 - 2017 U6 - https://doi.org/10.1021/acs.biomac.7b01034 SN - 1525-7797 SN - 1526-4602 VL - 18 SP - 3819 EP - 3833 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Xie, Dongjiu A1 - Xu, Yaolin A1 - Wang, Yonglei A1 - Pan, Xuefeng A1 - Härk, Eneli A1 - Kochovski, Zdravko A1 - Eljarrat, Alberto A1 - Müller, Johannes A1 - Koch, Christoph T. A1 - Yuan, Jiayin A1 - Lu, Yan T1 - Poly(ionic liquid) nanovesicle-templated carbon nanocapsules functionalized with uniform iron nitride nanoparticles as catalytic sulfur host for Li-S batteries JF - ACS nano N2 - Poly(ionic liquid)s (PIL) are common precursors for heteroatom-doped carbon materials. Despite a relatively higher carbonization yield, the PIL-to-carbon conversion process faces challenges in preserving morphological and structural motifs on the nanoscale. Assisted by a thin polydopamine coating route and ion exchange, imidazoliumbased PIL nanovesicles were successfully applied in morphology-maintaining carbonization to prepare carbon composite nanocapsules. Extending this strategy further to their composites, we demonstrate the synthesis of carbon composite nanocapsules functionalized with iron nitride nanoparticles of an ultrafine, uniform size of 3-5 nm (termed "FexN@C "). Due to its unique nanostructure, the sulfur-loaded FexN@C electrode was tested to efficiently mitigate the notorious shuttle effect of lithium polysulfides (LiPSs) in Li-S batteries. The cavity of the carbon nanocapsules was spotted to better the loading content of sulfur. The well-dispersed iron nitride nanoparticles effectively catalyze the conversion of LiPSs to Li2S, owing to their high electronic conductivity and strong binding power to LiPSs. Benefiting from this well-crafted composite nanostructure, the constructed FexN@C/S cathode demonstrated a fairly high discharge capacity of 1085 mAh g(-1) at 0.5 C initially, and a remaining value of 930 mAh g(-1 )after 200 cycles. In addition, it exhibits an excellent rate capability with a high initial discharge capacity of 889.8 mAh g(-1) at 2 C. This facile PIL-to-nanocarbon synthetic approach is applicable for the exquisite design of complex hybrid carbon nanostructures with potential use in electrochemical energy storage and conversion. KW - poly(ionic liquid)s KW - nanovesicles KW - sulfur host KW - iron nitride KW - Li-S KW - batteries Y1 - 2022 U6 - https://doi.org/10.1021/acsnano.2c01992 SN - 1936-0851 SN - 1936-086X VL - 16 IS - 7 SP - 10554 EP - 10565 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Tung, Wing Tai A1 - Maring, Janita A. A1 - Xu, Xun A1 - Liu, Yue A1 - Becker, Matthias A1 - Somesh, Dipthi Bachamanda A1 - Klose, Kristin A1 - Wang, Weiwei A1 - Sun, Xianlei A1 - Ullah, Imran A1 - Kratz, Karl A1 - Neffe, Axel T. A1 - Stamm, Christof A1 - Ma, Nan A1 - Lendlein, Andreas T1 - In vivo performance of a cell and factor free multifunctional fiber mesh modulating postinfarct myocardial remodeling JF - Advanced Functional Materials N2 - Guidance of postinfarct myocardial remodeling processes by an epicardial patch system may alleviate the consequences of ischemic heart disease. As macrophages are highly relevant in balancing immune response and regenerative processes their suitable instruction would ensure therapeutic success. A polymeric mesh capable of attracting and instructing monocytes by purely physical cues and accelerating implant degradation at the cell/implant interface is designed. In a murine model for myocardial infarction the meshes are compared to those either coated with extracellular matrix or loaded with induced cardiomyocyte progenitor cells. All implants promote macrophage infiltration and polarization in the epicardium, which is verified by in vitro experiments. 6 weeks post-MI, especially the implantation of the mesh attenuates left ventricular adverse remodeling processes as shown by reduced infarct size (14.7% vs 28-32%) and increased wall thickness (854 mu m vs 400-600 mu m), enhanced angiogenesis/arteriogenesis (more than 50% increase compared to controls and other groups), and improved heart function (ejection fraction = 36.8% compared to 12.7-31.3%). Upscaling as well as process controls is comprehensively considered in the presented mesh fabrication scheme to warrant further progression from bench to bedside. KW - bioinstructive materials KW - cardiac regeneration KW - function by structure; KW - modulation of in vivo regeneration KW - multifunctional biomaterials Y1 - 2022 U6 - https://doi.org/10.1002/adfm.202110179 SN - 1616-301X SN - 1616-3028 VL - 32 IS - 31 PB - Wiley CY - Weinheim ER - TY - GEN A1 - Xie, Chao A1 - Jia, Tianye A1 - Rolls, Edmund T. A1 - Robbins, Trevor W. A1 - Sahakian, Barbara J. A1 - Zhang, Jie A1 - Liu, Zhaowen A1 - Cheng, Wei A1 - Luo, Qiang A1 - Zac Lo, Chun-Yi A1 - Schumann, Gunter A1 - Feng, Jianfeng A1 - Wang, He A1 - Banaschewski, Tobias A1 - Barker, Gareth J. A1 - Bokde, Arun L.W. A1 - Büchel, Christian A1 - Quinlan, Erin Burke A1 - Desrivières, Sylvane A1 - Flor, Herta A1 - Grigis, Antoine A1 - Garavan, Hugh A1 - Gowland, Penny A1 - Heinz, Andreas A1 - Hohmann, Sarah A1 - Ittermann, Bernd A1 - Martinot, Jean-Luc A1 - Paillère Martinot, Marie-Laure A1 - Nees, Frauke A1 - Papadopoulos Orfanos, Dimitri A1 - Paus, Tomáš A1 - Poustka, Luise A1 - Fröhner, Juliane H. A1 - Smolka, Michael N. A1 - Walter, Henrik A1 - Whelan, Robert T1 - Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe N2 - BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms. METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14. RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003). CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 860 KW - adolescents KW - depression KW - monetary incentive delay task KW - nonreward sensitivity KW - orbitofrontal cortex KW - reward anticipation KW - reward sensitivity KW - ventral striatum Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-557882 SN - 1866-8364 IS - 3 ER - TY - JOUR A1 - Xie, Chao A1 - Jia, Tianye A1 - Rolls, Edmund T. A1 - Robbins, Trevor W. A1 - Sahakian, Barbara J. A1 - Zhang, Jie A1 - Liu, Zhaowen A1 - Cheng, Wei A1 - Luo, Qiang A1 - Zac Lo, Chun-Yi A1 - Schumann, Gunter A1 - Feng, Jianfeng A1 - Wang, He A1 - Banaschewski, Tobias A1 - Barker, Gareth J. A1 - Bokde, Arun L.W. A1 - Büchel, Christian A1 - Quinlan, Erin Burke A1 - Desrivières, Sylvane A1 - Flor, Herta A1 - Grigis, Antoine A1 - Garavan, Hugh A1 - Gowland, Penny A1 - Heinz, Andreas A1 - Hohmann, Sarah A1 - Ittermann, Bernd A1 - Martinot, Jean-Luc A1 - Paillère Martinot, Marie-Laure A1 - Nees, Frauke A1 - Papadopoulos Orfanos, Dimitri A1 - Paus, Tomáš A1 - Poustka, Luise A1 - Fröhner, Juliane H. A1 - Smolka, Michael N. A1 - Walter, Henrik A1 - Whelan, Robert T1 - Reward versus nonreward sensitivity of the medial versus lateral orbitofrontal cortex relates to the severity of depressive symptoms JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging N2 - BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms. METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14. RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003). CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores. KW - adolescents KW - depression KW - monetary incentive delay task KW - nonreward sensitivity KW - orbitofrontal cortex KW - reward anticipation KW - reward sensitivity KW - ventral striatum Y1 - 2021 U6 - https://doi.org/10.1016/j.bpsc.2020.08.017 SN - 2451-9022 SN - 2451-9030 VL - 6 IS - 3 SP - 259 EP - 269 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Levermann, Anders A1 - Winkelmann, Ricarda A1 - Nowicki, S. A1 - Fastook, J. L. A1 - Frieler, Katja A1 - Greve, R. A1 - Hellmer, H. H. A1 - Martin, M. A. A1 - Meinshausen, Malte A1 - Mengel, Matthias A1 - Payne, A. J. A1 - Pollard, D. A1 - Sato, T. A1 - Timmermann, R. A1 - Wang, Wei Li A1 - Bindschadler, Robert A. T1 - Projecting antarctic ice discharge using response functions from SeaRISE ice-sheet models JF - Earth system dynamics N2 - The largest uncertainty in projections of future sea-level change results from the potentially changing dynamical ice discharge from Antarctica. Basal ice-shelf melting induced by a warming ocean has been identified as a major cause for additional ice flow across the grounding line. Here we attempt to estimate the uncertainty range of future ice discharge from Antarctica by combining uncertainty in the climatic forcing, the oceanic response and the ice-sheet model response. The uncertainty in the global mean temperature increase is obtained from historically constrained emulations with the MAGICC-6.0 (Model for the Assessment of Greenhouse gas Induced Climate Change) model. The oceanic forcing is derived from scaling of the subsurface with the atmospheric warming from 19 comprehensive climate models of the Coupled Model Intercomparison Project (CMIP-5) and two ocean models from the EU-project Ice2Sea. The dynamic ice-sheet response is derived from linear response functions for basal ice-shelf melting for four different Antarctic drainage regions using experiments from the Sea-level Response to Ice Sheet Evolution (SeaRISE) intercomparison project with five different Antarctic ice-sheet models. The resulting uncertainty range for the historic Antarctic contribution to global sea-level rise from 1992 to 2011 agrees with the observed contribution for this period if we use the three ice-sheet models with an explicit representation of ice-shelf dynamics and account for the time-delayed warming of the oceanic subsurface compared to the surface air temperature. The median of the additional ice loss for the 21st century is computed to 0.07 m (66% range: 0.02-0.14 m; 90% range: 0.0-0.23 m) of global sea-level equivalent for the low-emission RCP-2.6 (Representative Concentration Pathway) scenario and 0.09 m (66% range: 0.04-0.21 m; 90% range: 0.01-0.37 m) for the strongest RCP-8.5. Assuming no time delay between the atmospheric warming and the oceanic subsurface, these values increase to 0.09 m (66% range: 0.04-0.17 m; 90% range: 0.02-0.25 m) for RCP-2.6 and 0.15 m (66% range: 0.07-0.28 m; 90% range: 0.04-0.43 m) for RCP-8.5. All probability distributions are highly skewed towards high values. The applied ice-sheet models are coarse resolution with limitations in the representation of grounding-line motion. Within the constraints of the applied methods, the uncertainty induced from different ice-sheet models is smaller than that induced by the external forcing to the ice sheets. Y1 - 2014 U6 - https://doi.org/10.5194/esd-5-271-2014 SN - 2190-4979 SN - 2190-4987 VL - 5 IS - 2 SP - 271 EP - 293 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Schaub, Torsten A1 - Wang, T. T1 - Preferred well-founded semantics for logic programming by alternating fixpoints : preliminary report Y1 - 2002 ER - TY - RPRT A1 - Brodeur, Abel A1 - Mikola, Derek A1 - Cook, Nikolai A1 - Brailey, Thomas A1 - Briggs, Ryan A1 - Gendre, Alexandra de A1 - Dupraz, Yannick A1 - Fiala, Lenka A1 - Gabani, Jacopo A1 - Gauriot, Romain A1 - Haddad, Joanne A1 - Lima, Goncalo A1 - Ankel-Peters, Jörg A1 - Dreber, Anna A1 - Campbell, Douglas A1 - Kattan, Lamis A1 - Fages, Diego Marino A1 - Mierisch, Fabian A1 - Sun, Pu A1 - Wright, Taylor A1 - Connolly, Marie A1 - Hoces de la Guardia, Fernando A1 - Johannesson, Magnus A1 - Miguel, Edward A1 - Vilhuber, Lars A1 - Abarca, Alejandro A1 - Acharya, Mahesh A1 - Adjisse, Sossou Simplice A1 - Akhtar, Ahwaz A1 - Lizardi, Eduardo Alberto Ramirez A1 - Albrecht, Sabina A1 - Andersen, Synve Nygaard A1 - Andlib, Zubaria A1 - Arrora, Falak A1 - Ash, Thomas A1 - Bacher, Etienne A1 - Bachler, Sebastian A1 - Bacon, Félix A1 - Bagues, Manuel A1 - Balogh, Timea A1 - Batmanov, Alisher A1 - Barschkett, Mara A1 - Basdil, B. Kaan A1 - Dower, Jaromneda A1 - Castek, Ondrej A1 - Caviglia-Harris, Jill A1 - Strand, Gabriella Chauca A1 - Chen, Shi A1 - Chzhen, Asya A1 - Chung, Jong A1 - Collins, Jason A1 - Coppock, Alexander A1 - Cordeau, Hugo A1 - Couillard, Ben A1 - Crechet, Jonathan A1 - Crippa, Lorenzo A1 - Cui, Jeanne A1 - Czymara, Christian A1 - Daarstad, Haley A1 - Dao, Danh Chi A1 - Dao, Dong A1 - Schmandt, Marco David A1 - Linde, Astrid de A1 - Melo, Lucas De A1 - Deer, Lachlan A1 - Vera, Micole De A1 - Dimitrova, Velichka A1 - Dollbaum, Jan Fabian A1 - Dollbaum, Jan Matti A1 - Donnelly, Michael A1 - Huynh, Luu Duc Toan A1 - Dumbalska, Tsvetomira A1 - Duncan, Jamie A1 - Duong, Kiet Tuan A1 - Duprey, Thibaut A1 - Dworschak, Christoph A1 - Ellingsrud, Sigmund A1 - Elminejad, Ali A1 - Eissa, Yasmine A1 - Erhart, Andrea A1 - Etingin-Frati, Giulian A1 - Fatemi-Pour, Elaheh A1 - Federice, Alexa A1 - Feld, Jan A1 - Fenig, Guidon A1 - Firouzjaeiangalougah, Mojtaba A1 - Fleisje, Erlend A1 - Fortier-Chouinard, Alexandre A1 - Engel, Julia Francesca A1 - Fries, Tilman A1 - Fortier, Reid A1 - Fréchet, Nadjim A1 - Galipeau, Thomas A1 - Gallegos, Sebastián A1 - Gangji, Areez A1 - Gao, Xiaoying A1 - Garnache, Cloé A1 - Gáspár, Attila A1 - Gavrilova, Evelina A1 - Ghosh, Arijit A1 - Gibney, Garreth A1 - Gibson, Grant A1 - Godager, Geir A1 - Goff, Leonard A1 - Gong, Da A1 - González, Javier A1 - Gretton, Jeremy A1 - Griffa, Cristina A1 - Grigoryeva, Idaliya A1 - Grtting, Maja A1 - Guntermann, Eric A1 - Guo, Jiaqi A1 - Gugushvili, Alexi A1 - Habibnia, Hooman A1 - Häffner, Sonja A1 - Hall, Jonathan D. A1 - Hammar, Olle A1 - Kordt, Amund Hanson A1 - Hashimoto, Barry A1 - Hartley, Jonathan S. A1 - Hausladen, Carina I. A1 - Havránek, Tomáš A1 - Hazen, Jacob A1 - He, Harry A1 - Hepplewhite, Matthew A1 - Herrera-Rodriguez, Mario A1 - Heuer, Felix A1 - Heyes, Anthony A1 - Ho, Anson T. Y. A1 - Holmes, Jonathan A1 - Holzknecht, Armando A1 - Hsu, Yu-Hsiang Dexter A1 - Hu, Shiang-Hung A1 - Huang, Yu-Shiuan A1 - Huebener, Mathias A1 - Huber, Christoph A1 - Huynh, Kim P. A1 - Irsova, Zuzana A1 - Isler, Ozan A1 - Jakobsson, Niklas A1 - Frith, Michael James A1 - Jananji, Raphaël A1 - Jayalath, Tharaka A. A1 - Jetter, Michael A1 - John, Jenny A1 - Forshaw, Rachel Joy A1 - Juan, Felipe A1 - Kadriu, Valon A1 - Karim, Sunny A1 - Kelly, Edmund A1 - Dang, Duy Khanh Hoang A1 - Khushboo, Tazia A1 - Kim, Jin A1 - Kjellsson, Gustav A1 - Kjelsrud, Anders A1 - Kotsadam, Andreas A1 - Korpershoek, Jori A1 - Krashinsky, Lewis A1 - Kundu, Suranjana A1 - Kustov, Alexander A1 - Lalayev, Nurlan A1 - Langlois, Audrée A1 - Laufer, Jill A1 - Lee-Whiting, Blake A1 - Leibing, Andreas A1 - Lenz, Gabriel A1 - Levin, Joel A1 - Li, Peng A1 - Li, Tongzhe A1 - Lin, Yuchen A1 - Listo, Ariel A1 - Liu, Dan A1 - Lu, Xuewen A1 - Lukmanova, Elvina A1 - Luscombe, Alex A1 - Lusher, Lester R. A1 - Lyu, Ke A1 - Ma, Hai A1 - Mäder, Nicolas A1 - Makate, Clifton A1 - Malmberg, Alice A1 - Maitra, Adit A1 - Mandas, Marco A1 - Marcus, Jan A1 - Margaryan, Shushanik A1 - Márk, Lili A1 - Martignano, Andres A1 - Marsh, Abigail A1 - Masetto, Isabella A1 - McCanny, Anthony A1 - McManus, Emma A1 - McWay, Ryan A1 - Metson, Lennard A1 - Kinge, Jonas Minet A1 - Mishra, Sumit A1 - Mohnen, Myra A1 - Möller, Jakob A1 - Montambeault, Rosalie A1 - Montpetit, Sébastien A1 - Morin, Louis-Philippe A1 - Morris, Todd A1 - Moser, Scott A1 - Motoki, Fabio A1 - Muehlenbachs, Lucija A1 - Musulan, Andreea A1 - Musumeci, Marco A1 - Nabin, Munirul A1 - Nchare, Karim A1 - Neubauer, Florian A1 - Nguyen, Quan M. P. A1 - Nguyen, Tuan A1 - Nguyen-Tien, Viet A1 - Niazi, Ali A1 - Nikolaishvili, Giorgi A1 - Nordstrom, Ardyn A1 - Nü, Patrick A1 - Odermatt, Angela A1 - Olson, Matt A1 - ien, Henning A1 - Ölkers, Tim A1 - Vert, Miquel Oliver i. A1 - Oral, Emre A1 - Oswald, Christian A1 - Ousman, Ali A1 - Özak, Ömer A1 - Pandey, Shubham A1 - Pavlov, Alexandre A1 - Pelli, Martino A1 - Penheiro, Romeo A1 - Park, RyuGyung A1 - Martel, Eva Pérez A1 - Petrovičová, Tereza A1 - Phan, Linh A1 - Prettyman, Alexa A1 - Procházka, Jakub A1 - Putri, Aqila A1 - Quandt, Julian A1 - Qiu, Kangyu A1 - Nguyen, Loan Quynh Thi A1 - Rahman, Andaleeb A1 - Rea, Carson H. A1 - Reiremo, Adam A1 - Renée, Laëtitia A1 - Richardson, Joseph A1 - Rivers, Nicholas A1 - Rodrigues, Bruno A1 - Roelofs, William A1 - Roemer, Tobias A1 - Rogeberg, Ole A1 - Rose, Julian A1 - Roskos-Ewoldsen, Andrew A1 - Rosmer, Paul A1 - Sabada, Barbara A1 - Saberian, Soodeh A1 - Salamanca, Nicolas A1 - Sator, Georg A1 - Sawyer, Antoine A1 - Scates, Daniel A1 - Schlüter, Elmar A1 - Sells, Cameron A1 - Sen, Sharmi A1 - Sethi, Ritika A1 - Shcherbiak, Anna A1 - Sogaolu, Moyosore A1 - Soosalu, Matt A1 - Srensen, Erik A1 - Sovani, Manali A1 - Spencer, Noah A1 - Staubli, Stefan A1 - Stans, Renske A1 - Stewart, Anya A1 - Stips, Felix A1 - Stockley, Kieran A1 - Strobel, Stephenson A1 - Struby, Ethan A1 - Tang, John A1 - Tanrisever, Idil A1 - Yang, Thomas Tao A1 - Tastan, Ipek A1 - Tatić, Dejan A1 - Tatlow, Benjamin A1 - Seuyong, Féraud Tchuisseu A1 - Thériault, Rémi A1 - Thivierge, Vincent A1 - Tian, Wenjie A1 - Toma, Filip-Mihai A1 - Totarelli, Maddalena A1 - Tran, Van-Anh A1 - Truong, Hung A1 - Tsoy, Nikita A1 - Tuzcuoglu, Kerem A1 - Ubfal, Diego A1 - Villalobos, Laura A1 - Walterskirchen, Julian A1 - Wang, Joseph Taoyi A1 - Wattal, Vasudha A1 - Webb, Matthew D. A1 - Weber, Bryan A1 - Weisser, Reinhard A1 - Weng, Wei-Chien A1 - Westheide, Christian A1 - White, Kimberly A1 - Winter, Jacob A1 - Wochner, Timo A1 - Woerman, Matt A1 - Wong, Jared A1 - Woodard, Ritchie A1 - Wroński, Marcin A1 - Yazbeck, Myra A1 - Yang, Gustav Chung A1 - Yap, Luther A1 - Yassin, Kareman A1 - Ye, Hao A1 - Yoon, Jin Young A1 - Yurris, Chris A1 - Zahra, Tahreen A1 - Zaneva, Mirela A1 - Zayat, Aline A1 - Zhang, Jonathan A1 - Zhao, Ziwei A1 - Yaolang, Zhong T1 - Mass reproducibility and replicability BT - a new hope T2 - I4R discussion paper series N2 - This study pushes our understanding of research reliability by reproducing and replicating claims from 110 papers in leading economic and political science journals. The analysis involves computational reproducibility checks and robustness assessments. It reveals several patterns. First, we uncover a high rate of fully computationally reproducible results (over 85%). Second, excluding minor issues like missing packages or broken pathways, we uncover coding errors for about 25% of studies, with some studies containing multiple errors. Third, we test the robustness of the results to 5,511 re-analyses. We find a robustness reproducibility of about 70%. Robustness reproducibility rates are relatively higher for re-analyses that introduce new data and lower for re-analyses that change the sample or the definition of the dependent variable. Fourth, 52% of re-analysis effect size estimates are smaller than the original published estimates and the average statistical significance of a re-analysis is 77% of the original. Lastly, we rely on six teams of researchers working independently to answer eight additional research questions on the determinants of robustness reproducibility. Most teams find a negative relationship between replicators' experience and reproducibility, while finding no relationship between reproducibility and the provision of intermediate or even raw data combined with the necessary cleaning codes. KW - conomics KW - open science KW - political science KW - replication KW - reproduction KW - research transparency Y1 - 2024 SN - 2752-1931 IS - 107 PB - Institute for Replication CY - Essen ER -