TY  - BOOK
A1  - Mientus, Lukas
A1  - Klempin, Christiane
A1  - Nowak, Anna
A1  - Wyss, Corinne
A1  - Aufschnaiter, Claudia von
A1  - Faix, Ann-Christin
A1  - te Poel, Kathrin
A1  - Wahbe, Nadia
A1  - Pieper, Martin
A1  - Höller, Katharina
A1  - Kallenbach, Lea
A1  - Förster, Magdalena
A1  - Redecker, Anke
A1  - Dick, Mirjam
A1  - Holle, Jörg
A1  - Schneider, Edina
A1  - Rehfeldt, Daniel
A1  - Brauns, Sarah
A1  - Abels, Simone
A1  - Ferencik-Lehmkuhl, Daria
A1  - Fränkel, Silvia
A1  - Frohn, Julia
A1  - Liebsch, Ann-Catherine
A1  - Pech, Detlef
A1  - Schreier, Pascal
A1  - Jessen, Moiken
A1  - Großmann, Uta
A1  - Skintey, Lesya
A1  - Voerkel, Paul
A1  - Vaz Ferreira, Mergenfel A.
A1  - Zimmermann, Jan-Simon
A1  - Buddeberg, Magdalena
A1  - Henke, Vanessa
A1  - Hornberg, Sabine
A1  - Völschow, Yvette
A1  - Warrelmann, Julia-Nadine
A1  - Malek, Jennifer
A1  - Tinnefeld, Anja
A1  - Schmidt, Peggy
A1  - Bauer, Tobias
A1  - Jänisch, Christopher
A1  - Spitzer, Lisa
A1  - Franken, Nadine
A1  - Degeling, Maria
A1  - Preisfeld, Angelika
A1  - Meier, Jana
A1  - Küth, Simon
A1  - Scholl, Daniel
A1  - Vogelsang, Christoph
A1  - Watson, Christina
A1  - Weißbach, Anna
A1  - Kulgemeyer, Christoph
A1  - Oetken, Mandy
A1  - Gorski, Sebastian
A1  - Kubsch, Marcus
A1  - Sorge, Stefan
A1  - Wulff, Peter
A1  - Fellenz, Carolin D.
A1  - Schnell, Susanne
A1  - Larisch, Cathleen
A1  - Kaiser, Franz
A1  - Knott, Christina
A1  - Reimer, Stefanie
A1  - Stegmüller, Nathalie
A1  - Boukrayâa Trabelsi, Kathrin
A1  - Schißlbauer, Franziska
A1  - Lemberger, Lukas
A1  - Barth, Ulrike
A1  - Wiehl, Angelika
A1  - Rogge, Tim
A1  - Böhnke, Anja
A1  - Dietz, Dennis
A1  - Großmann, Leroy
A1  - Wienmeister, Annett
A1  - Zoppke, Till
A1  - Jiang, Lisa
A1  - Grünbauer, Stephanie
A1  - Ostersehlt, Dörte
A1  - Peukert, Sophia
A1  - Schäfer, Christoph
A1  - Löbig, Anna
A1  - Bröll, Leena
A1  - Brandt, Birgit
A1  - Breuer, Meike
A1  - Dausend, Henriette
A1  - Krelle, Michael
A1  - Andersen, Gesine
A1  - Falke, Sascha
A1  - Kindermann-Güzel, Kristin
A1  - Körner, Katrina
A1  - Lottermoser, Lisa-Marie
A1  - Pügner, Kati
A1  - Sonnenburg, Nadine
A1  - Akarsu, Selim
A1  - Rechl, Friederike
A1  - Gadinger, Laureen
A1  - Heinze, Lena
A1  - Wittmann, Eveline
A1  - Franke, Manuela
A1  - Lachmund, Anne-Marie
A1  - Böttger, Julia
A1  - Hannover, Bettina
A1  - Behrendt, Renata
A1  - Conty, Valentina
A1  - Grundmann, Stephanie
A1  - Ghassemi, Novid
A1  - Opitz, Ben
A1  - Brämer, Martin
A1  - Gasparjan, David
A1  - Sambanis, Michaela
A1  - Köster, Hilde
A1  - Lücke, Martin
A1  - Nordmeier, Volkhard
A1  - Schaal, Sonja
A1  - Haberbosch, Maximilian
A1  - Meissner, Maren
A1  - Schaal, Steffen
A1  - Brüchner, Melanie
A1  - Riehle, Tamara
A1  - Leopold, Bengta Marie
A1  - Gerlach, Susanne
A1  - Rau-Patschke, Sarah
A1  - Skorsetz, Nina
A1  - Weber, Nadine
A1  - Damköhler, Jens
A1  - Elsholz, Markus
A1  - Trefzger, Thomas
A1  - Lewek, Tobias
A1  - Borowski, Andreas
ED  - Mientus, Lukas
ED  - Klempin, Christiane
ED  - Nowak, Anna
T1  - Reflexion in der Lehrkräftebildung
BT  - Empirisch – Phasenübergreifend – Interdisziplinär
T3  - Potsdamer Beiträge für Lehrkräftebildung und Bildungsforschung
N2  - Reflexion ist eine Schlüsselkategorie für die professionelle Entwicklung von Lehrkräften, welche als Ausbildungsziel in den Bildungsstandards für die Lehrkräftebildung verankert ist. Eine Verstetigung universitär geprägter Forschung und Modellierung in der praxisnahen Anwendung im schulischen Kontext bietet Potentiale nachhaltiger Professionalisierung. Die Stärkung reflexionsbezogener Kompetenzen durch Empirie und Anwendung scheint eine phasenübergreifende Herausforderung der Lehrkräftebildung zu sein, die es zu bewältigen gilt. Ziele des Tagungsbandes Reflexion in der Lehrkräftebildung sind eine theoretische Schärfung des Konzeptes „Reflexive Professionalisierung“ und der Austausch über Fragen der Einbettung wirksamer reflexionsbezogener Lerngelegenheiten in die Lehrkräftebildung. Forschende und Lehrende der‚ drei Phasen (Studium, Referendariat sowie Fort- und Weiterbildung) der Lehrkräftebildung stellen Lehrkonzepte und Forschungsprojekte zum Thema Reflexion in der Lehrkräftebildung vor und diskutieren diese. Gemeinsam mit Teilnehmenden aller Phasen und von verschiedenen Standorten der Lehrkräftebildung werden zukünftige Herausforderungen identifiziert und Lösungsansätze herausgearbeitet.
T3  - Potsdamer Beiträge zur Lehrkräftebildung und Bildungsforschung - 4 
KW  - Reflexion
KW  - Lehrkräftebildung
KW  - Reflexionskompetenz
KW  - Reflexivität
KW  - Feedback
KW  - Reflection
KW  - Teacher Education
KW  - Reflection Skills
KW  - Reflexivity
KW  - Feedback
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-591717
SN  - 978-3-86956-566-8
SN  - 2626-3556
SN  - 2626-4722
IS  - 4
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Menzel, Michael
A1  - Wehlmann, Kerstin
A1  - Hönisch, Martin
A1  - Bergemann, Susann
A1  - Mücklich, Franziska
A1  - Ruge, Jasmin
A1  - Sumida, Nanni
A1  - Bieder, Anja
A1  - Spreewald, Stefanie
A1  - Simon, Jörn
A1  - Freese, Anika
A1  - Bormann, Janine
A1  - Klinge, Henry
A1  - Böhme, Jan-Christoph
A1  - Fachini, Marion
A1  - Guß, Janine
A1  - Schüler, Susanne
A1  - Walter, Susanne
A1  - Kaden, Sandra
A1  - Kalus, Matthias
A1  - Berg, Ronald
A1  - Pape, Christine
ED  - Klose, Dagmar
ED  - Ladewig, Marco
T1  - Freiheit im Mittelalter am Beispiel der Stadt
N2  - Kirchtürme und Zunfthäuser, Marktplätze und enge – oft verdreckte – Gassen zeichnen unser modernes Bild der mittelalterlichen Stadt. Dieser „Ort“ war Forum und Zentrum des mittelalterlichen Lebens, dessen Vielfalt und Komplexität sich für uns wie durch ein Brennglas beobachten lässt. Dieser Band in der Reihe „Perspektiven historischen Denkens“ thematisiert die „städtische Freiheit“ unter geschichtsdidaktischen Aspekten. Junge Autorinnen und Autoren stellen hierin schülerzentrierte und narrative Lernarrangements vor, die mit quellengestützten Arbeitsmaterialien multiperspektivische Zugänge zur Thematik „Freiheit am Beispiel der mittelalterlichen Stadt“ (RLP Berlin-Brandenburg) ermöglichen. Vorweg gestellte Informationstexte gestatten den Lehrerinnen und Lehrern einen leichtverständlich und fachlich fundierten Einblick in die Thematik und lohten das methodisch-didaktische Potential der Lernarrangements aus. Im sich anschließenden Materialteil können Sie als Lehrkraft aus dem breiten Text- und Bildfundus eine für ihren individuellen Unterricht angepasste Auswahl treffen und ihre Schüler für einen kurzweiligen und handlungsorientierten Unterricht begeistern.
T3  - Perspektiven historischen Denkens und Lernens - 4 
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-31417
SN  - 978-3-940793-95-9
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Selting, Margret
A1  - Auer, Peter
A1  - Barth-Weingarten, Dagmar
A1  - Bergmann, Jörg
A1  - Bergmann, Pia
A1  - Birkner, Karin
A1  - Couper-Kuhlen, Elizabeth
A1  - Deppermann, Arnulf
A1  - Gilles, Peter
A1  - Günthner, Susanne
A1  - Hartung, Martin
A1  - Kern, Friederike
A1  - Mertzlufft, Christine
A1  - Meyer, Christian
A1  - Morek, Miriam
A1  - Oberzaucher, Frank
A1  - Peters, Jörg
A1  - Quasthoff, Uta
A1  - Schütte, Wilfried
A1  - Stukenbrock, Anja
A1  - Uhmann, Susanne
T1  - Gesprächsanalytisches Transkriptionssystem 2 (GAT 2)
Y1  - 2009
UR  - http://www.gespraechsforschung-ozs.de/heft2009/px-gat2.pdf (12.9.13)
SN  - 1617-1837
ER  - 
TY  - JOUR
A1  - Tucker, Marlee A.
A1  - Boehning-Gaese, Katrin
A1  - Fagan, William F.
A1  - Fryxell, John M.
A1  - Van Moorter, Bram
A1  - Alberts, Susan C.
A1  - Ali, Abdullahi H.
A1  - Allen, Andrew M.
A1  - Attias, Nina
A1  - Avgar, Tal
A1  - Bartlam-Brooks, Hattie
A1  - Bayarbaatar, Buuveibaatar
A1  - Belant, Jerrold L.
A1  - Bertassoni, Alessandra
A1  - Beyer, Dean
A1  - Bidner, Laura
A1  - van Beest, Floris M.
A1  - Blake, Stephen
A1  - Blaum, Niels
A1  - Bracis, Chloe
A1  - Brown, Danielle
A1  - de Bruyn, P. J. Nico
A1  - Cagnacci, Francesca
A1  - Calabrese, Justin M.
A1  - Camilo-Alves, Constanca
A1  - Chamaille-Jammes, Simon
A1  - Chiaradia, Andre
A1  - Davidson, Sarah C.
A1  - Dennis, Todd
A1  - DeStefano, Stephen
A1  - Diefenbach, Duane
A1  - Douglas-Hamilton, Iain
A1  - Fennessy, Julian
A1  - Fichtel, Claudia
A1  - Fiedler, Wolfgang
A1  - Fischer, Christina
A1  - Fischhoff, Ilya
A1  - Fleming, Christen H.
A1  - Ford, Adam T.
A1  - Fritz, Susanne A.
A1  - Gehr, Benedikt
A1  - Goheen, Jacob R.
A1  - Gurarie, Eliezer
A1  - Hebblewhite, Mark
A1  - Heurich, Marco
A1  - Hewison, A. J. Mark
A1  - Hof, Christian
A1  - Hurme, Edward
A1  - Isbell, Lynne A.
A1  - Janssen, Rene
A1  - Jeltsch, Florian
A1  - Kaczensky, Petra
A1  - Kane, Adam
A1  - Kappeler, Peter M.
A1  - Kauffman, Matthew
A1  - Kays, Roland
A1  - Kimuyu, Duncan
A1  - Koch, Flavia
A1  - Kranstauber, Bart
A1  - LaPoint, Scott
A1  - Leimgruber, Peter
A1  - Linnell, John D. C.
A1  - Lopez-Lopez, Pascual
A1  - Markham, A. Catherine
A1  - Mattisson, Jenny
A1  - Medici, Emilia Patricia
A1  - Mellone, Ugo
A1  - Merrill, Evelyn
A1  - Mourao, Guilherme de Miranda
A1  - Morato, Ronaldo G.
A1  - Morellet, Nicolas
A1  - Morrison, Thomas A.
A1  - Diaz-Munoz, Samuel L.
A1  - Mysterud, Atle
A1  - Nandintsetseg, Dejid
A1  - Nathan, Ran
A1  - Niamir, Aidin
A1  - Odden, John
A1  - Oliveira-Santos, Luiz Gustavo R.
A1  - Olson, Kirk A.
A1  - Patterson, Bruce D.
A1  - de Paula, Rogerio Cunha
A1  - Pedrotti, Luca
A1  - Reineking, Bjorn
A1  - Rimmler, Martin
A1  - Rogers, Tracey L.
A1  - Rolandsen, Christer Moe
A1  - Rosenberry, Christopher S.
A1  - Rubenstein, Daniel I.
A1  - Safi, Kamran
A1  - Said, Sonia
A1  - Sapir, Nir
A1  - Sawyer, Hall
A1  - Schmidt, Niels Martin
A1  - Selva, Nuria
A1  - Sergiel, Agnieszka
A1  - Shiilegdamba, Enkhtuvshin
A1  - Silva, Joao Paulo
A1  - Singh, Navinder
A1  - Solberg, Erling J.
A1  - Spiegel, Orr
A1  - Strand, Olav
A1  - Sundaresan, Siva
A1  - Ullmann, Wiebke
A1  - Voigt, Ulrich
A1  - Wall, Jake
A1  - Wattles, David
A1  - Wikelski, Martin
A1  - Wilmers, Christopher C.
A1  - Wilson, John W.
A1  - Wittemyer, George
A1  - Zieba, Filip
A1  - Zwijacz-Kozica, Tomasz
A1  - Mueller, Thomas
T1  - Moving in the Anthropocene
BT  - global reductions in terrestrial mammalian movements
JF  - Science
N2  - Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
Y1  - 2018
U6  - https://doi.org/10.1126/science.aam9712
SN  - 0036-8075
SN  - 1095-9203
VL  - 359
IS  - 6374
SP  - 466
EP  - 469
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - van der Plas, Fons
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Renner, Swen C.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Boch, Steffen
A1  - Böhm, Stefan
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Heinze, Johannes
A1  - Hölzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schöning, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Türke, Manfred
A1  - Venter, Paul C.
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality
JF  - Nature : the international weekly journal of science
Y1  - 2016
U6  - https://doi.org/10.1038/nature19092
SN  - 0028-0836
SN  - 1476-4687
VL  - 536
SP  - 456
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Bluethgen, Nico
A1  - Boch, Steffen
A1  - Boehm, Stefan
A1  - Boerschig, Carmen
A1  - Buscot, Francois
A1  - Diekoetter, Tim
A1  - Heinze, Johannes
A1  - Hoelzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Klein, Alexandra-Maria
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Mueller, Joerg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schoening, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Tuerke, Manfred
A1  - Venter, Paul
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Locally rare species influence grassland ecosystem multifunctionality
JF  - Philosophical transactions of the Royal Society of London : B, Biological sciences
N2  - Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities.
KW  - biodiversity
KW  - common species
KW  - ecosystem function
KW  - identity hypothesis
KW  - land use
KW  - multitrophic
Y1  - 2016
U6  - https://doi.org/10.1098/rstb.2015.0269
SN  - 0962-8436
SN  - 1471-2970
VL  - 371
SP  - 3175
EP  - 3185
PB  - Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Nickerson, David
A1  - Atalag, Koray
A1  - de Bono, Bernard
A1  - Geiger, Joerg
A1  - Goble, Carole
A1  - Hollmann, Susanne
A1  - Lonien, Joachim
A1  - Mueller, Wolfgang
A1  - Regierer, Babette
A1  - Stanford, Natalie J.
A1  - Golebiewski, Martin
A1  - Hunter, Peter
T1  - The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable
JF  - Interface focus
N2  - Reconstructing and understanding the Human Physiome virtually is a complex mathematical problem, and a highly demanding computational challenge. Mathematical models spanning from the molecular level through to whole populations of individuals must be integrated, then personalized. This requires interoperability with multiple disparate and geographically separated data sources, and myriad computational software tools. Extracting and producing knowledge from such sources, even when the databases and software are readily available, is a challenging task. Despite the difficulties, researchers must frequently perform these tasks so that available knowledge can be continually integrated into the common framework required to realize the Human Physiome. Software and infrastructures that support the communities that generate these, together with their underlying standards to format, describe and interlink the corresponding data and computer models, are pivotal to the Human Physiome being realized. They provide the foundations for integrating, exchanging and re-using data and models efficiently, and correctly, while also supporting the dissemination of growing knowledge in these forms. In this paper, we explore the standards, software tooling, repositories and infrastructures that support this work, and detail what makes them vital to realizing the Human Physiome.
KW  - Human Physiome
KW  - standards
KW  - repositories
KW  - service infrastructure
KW  - reproducible science
KW  - managing big data
Y1  - 2016
U6  - https://doi.org/10.1098/rsfs.2015.0103
SN  - 2042-8898
SN  - 2042-8901
VL  - 6
SP  - 57
EP  - 61
PB  - Royal Society
CY  - London
ER  - 
TY  - BOOK
A1  - Neumann, Martin
A1  - Brandt-Wardenberg, Henriette
A1  - Brodowsky, Kristin
A1  - Ebert, Daniel
A1  - Hose, Susanne
A1  - Junge, Katrin
A1  - Kappler, Anna
A1  - Karges, Melanie
A1  - Lehnert, Annette
A1  - Richter, Olivia
A1  - Schirrmeister, Sebastian
A1  - Solich, Raphaela
A1  - Thaele, Liisa
A1  - Trenkner, Christina
A1  - Tschöpel, Sebastian
A1  - Unger, Katharina
A1  - Winkler, Anja
A1  - Zimmermann, Steven
A1  - Kirschke, Andreas
A1  - Ladusch, Manfred
T1  - Sorben (Wenden) - Eine Brandenburger Minderheit und ihre Thematisierung im Unterricht : Teil III: Krabat - Aspekte einer sorbischen Sage
N2  - Die vorliegende Publikation fällt ein wenig aus dem Rahmen der Reihe „Sorben (Wenden) - Eine Brandenburger Minderheit und ihre Thematisierung im Unterricht“. Im Gegensatz zu den anderen Teilen widmet sie sich nur einem Gegenstand - dem Stoff der Krabat-Sagen. Damit richtet sie sich hauptsächlich an Lehrkräfte im Fach Deutsch, wobei auch fachübergreifende und Fächer verbindende Aspekte berücksichtigt werden. Die Krabat-Sage zählt vor allem in der Bearbeitung von Preußler zu den bekanntesten sorbischen Stoffen. Diese sorbischen Wurzeln werden allerdings nur selten thematisiert. Daher sind viele der vorliegenden Betrachtungen zu ausgewählten Aspekten auch als Anregungen zu verstehen, unter welchen Gesichtspunkten Krabat behandelt oder gar neu interpretiert und weiterentwickelt werden könnte. Diese Handreichung ist so konzipiert, dass sie je nach Interesse ausschnittweise gelesen werden kann: Auf einen Überblick über verschiedene Krabat-Bearbeitungen folgen Betrachtungen sorbischer Aspekte als auch Möglichkeiten einer Thematisierung über den Deutsch-Unterricht hinaus. Dabei wird auf Möglichkeiten einer Exkursion in die historische Krabat-Region in der Lausitz eingegangen. Es folgen Texte zu ausgewählten Einzelaspekten. Zudem enthält diese Publikation eine Zusammenstellung von verschiedenen Krabat-Materialien und Hinweise auf Unterrichtsprojekte zur Anregung, weiteren Vertiefung bzw. für den eigenen Unterrichtseinsatz.
KW  - Sorben
KW  - Wenden
KW  - Unterricht
KW  - Krabat
Y1  - 2008
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-27315
ER  - 
TY  - JOUR
A1  - Kästner, Alexander
A1  - Schmitz, Claudia
A1  - Evert, Urte
A1  - Rogger, Philippe
A1  - Zielsdorf, Frank
A1  - Häcker, Susanne
A1  - Bahro, Steffi
A1  - Ludwig, Ulrike
A1  - Lang, Heinrich
A1  - Piltz, Eric
A1  - Winter, Martin
T1  - Militär und Gesellschaft in der Frühen Neuzeit
N2  - Inhalt: AUFSÄTZE Alexander Kästner: „Desertionen in das Jenseits.“ Ansätze und Desiderate einer militärhistorischen Suizidforschung für die Frühe Neuzeit. Claudia Schmitz: Der symbolische und religiöse Gehalt von Gewalt und Krieg im Prozess der inkaischen Staatsentwicklung. PROJEKTE Urte Evert: Die Eisenbraut. Symbolische Funktionen der soldatischen Waffe. Philippe Rogger: Pensionenunruhen 1513-1516. Klientelistische Verflechtung – herrschaftliche Verdichtung – bäuerlicher Widerstand? Frank Zielsdorf: Militärische Erinnerungskulturen zwischen Adelsmentalität und Professionalisierung. Regimentskulturen des preußischen Offizierskorps im 17. und 18. Jahrhundert. Susanne Häcker: Universität und Krieg. Die Auswirkungen des Dreißigjährigen Krieges auf die Universitäten Heidelberg, Tübingen und Freiburg. Steffi Bahro: „Solange der Krieg dauerte, ging alles gut...“ Der abgedankte Soldat im Märchen. TAGUNGSBERICHTE Ulrike Ludwig: Militärrecht in der Frühen Neuzeit, 7. Tagung des AMG (Bayreuth, 4.-7. Oktober 2007). REZENSIONEN Heinrich Lang: William Caferro, John Hawkwood. An English Mercenary in Fourteenth-Century Italy, Baltimore 2006. Eric Piltz: Steven G. Ellis, Raingard Eßer (Hrsg.), Frontiers and the Writing of History, 1500-1850, Hannover-Laatzen 2006. Martin Winter: Michael Epkenhans, Stig Förster, Karen Hagemann (Hrsg.), Militärische Erinnerungskultur. Soldaten im Spiegel von Biographien, Memoiren und Selbstzeugnissen, Paderborn 2006
T3  - Militär und Gesellschaft in der frühen Neuzeit - 11, Heft 2 
Y1  - 2007
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16036
SN  - 1617-9722
SN  - 1861-910X
VL  - 11
IS  - 2
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Schmitz, Claudia
A1  - Fuchs, Thomas
A1  - van Nimwegen, Olaf
A1  - Oestmann, Anne
A1  - Costello, Vivien
A1  - von Schnurbein, Vladimir
A1  - Probst, Thomas W.
A1  - Maier, Gregor
A1  - Jörgensen, Bent
A1  - Krug, Raphael Matthias
A1  - Lüdke, Christine
A1  - Schmitt, Bernhard
A1  - Franz, Matthias
A1  - Winter, Martin
A1  - Brockfeld, Susanne
T1  - Militär und Gesellschaft in der Frühen Neuzeit
N2  - Inhalt: Beiträge: Claudia Schmitz: Gewaltanwendung und -wahrnehmung in der frühen Kontaktsituation zwischen Indianern und Europäern, Peru 1532/33 Thomas Fuchs: Von der Büchersammlung zur Bibliothek. Regimentsbibliotheken des 18. und 19. Jahrhunderts in Hannover Olaf von Nimwegen: The Dutch Army and the Military Revolutions (1588-1688) Anne Oestmann: Billeting in England during the Reign of Charles I, 1625-1649, The Case of Tickhill/Yorkshire Projekte: Vivien Costello: Ein biographisches Lexikon hugenottischer Offiziere in europäischen Armeen 1660-1780 Vladimier von Schnurbein: Die Rolle des Johanniter-Ordens bei der kontinentalen Türkenabwehr im 16. Jahrhundert Berichte: Thomas W. Probst: Tagung des Arbeitskreises Militärgeschichte (AKM) 2005, "Kriegsgreuel", 3.-5. November 2005 in Mainz Gregor Maier: Krieg, Militär und Migration in der Frühen Neuzeit. 6. Jahrestagung des Arbeitskreises "Militär und Gesellschaft in der Frühen Neuzeit" gemeinsam mit dem Tübinger Sonderforschungsbereich 437 Bent Jörgensen, Raphael Matthias Krug, Christine Lüdke: Friedensschlüsse - Medien im Umfeld der Konfliktbewältigung im Mittelalter und der Frühen Neuzeit Horst Bernhard Schmitt: Militär und Gesellschaft in Herrschaftswechseln Rezensionen Matthias Franz: Jörg Rathjen: Soldaten im Dorf. Ländliche Gesellschaft und Kriege in den Herzogtümern Schleswig und Holstein Martin Winter: Peter Engerisser: Von Kronach nach Nördlingen. Der Dreißigjährige Krieg in Franken, Schwaben und der Oberpfalz 1631-1635 Ankündigungen Susanne Brockfeld: Staatsbankrott! Bankrotter Staat? Finanzreform und gesellschaftlicher Wandel in Preußen nach 1806. Eine Ausstellung des Geheimen Staatsarchivs Preußischer Kulturbesitz 12. Mai bis 28. Juni 2006 in Berlin Ich dien' nicht! Wehrdienstverweigerung in der Geschichte, Reinbek bei Hamburg, 20. bis 22. Oktober 2006
T3  - Militär und Gesellschaft in der frühen Neuzeit - 10, Heft 1 
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-12626
SN  - 1617-9722
SN  - 1861-910X
VL  - 10
IS  - 1
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Simons, Nadja K.
A1  - Lewinsohn, Thomas
A1  - Bluethgen, Nico
A1  - Buscot, Francois
A1  - Boch, Steffen
A1  - Daniel, Rolf
A1  - Gossner, Martin M.
A1  - Jung, Kirsten
A1  - Kaiser, Kristin
A1  - Müller, Jörg
A1  - Prati, Daniel
A1  - Renner, Swen C.
A1  - Socher, Stephanie A.
A1  - Sonnemann, Ilja
A1  - Weiner, Christiane N.
A1  - Werner, Michael
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Weisser, Wolfgang W.
T1  - Contrasting effects of grassland management modes on species-abundance distributions of multiple groups
JF  - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere
N2  - Intensive land use is a major cause of biodiversity loss, but most studies comparing the response of multiple taxa rely on simple diversity measures while analyses of other community attributes are only recently gaining attention. Species-abundance distributions (SADs) are a community attribute that can be used to study changes in the overall abundance structure of species groups, and whether these changes are driven by abundant or rare species. We evaluated the effect of grassland management intensity for three land-use modes (fertilization, mowing, grazing) and their combination on species richness and SADs for three belowground (arbuscular mycorrhizal fungi, prokaryotes and insect larvae) and seven aboveground groups (vascular plants, bryophytes and lichens; arthropod herbivores; arthropod pollinators; bats and birds). Three descriptors of SADs were evaluated: general shape (abundance decay rate), proportion of rare species (rarity) and proportional abundance of the commonest species (dominance). Across groups, taxonomic richness was largely unaffected by land-use intensity and only decreased with increasing mowing intensity. Of the three SAD descriptors, abundance decay rate became steeper with increasing combined land-use intensity across groups. This reflected a decrease in rarity among plants, herbivores and vertebrates. Effects of fertilization on the three descriptors were similar to the combined land-use intensity effects. Mowing intensity only affected the SAD descriptors of insect larvae and vertebrates, while grazing intensity produced a range of effects on different descriptors in distinct groups. Overall, belowground groups had more even abundance distribtitions than aboveground groups. Strong differences among aboveground groups and between above- and belowground groups indicate that no single taxonomic group can serve as an indicator for effects in other groups. In the past, the use of SADs has been hampered by concerns over theoretical models underlying specific forms of SADs. Our study shows that SAD descriptors that are not connected to a particular model are suitable to assess the effect of land use on community structure.
KW  - Biodiversity
KW  - Cutting frequency
KW  - Management intensity
KW  - Rank-abundance
KW  - Species loss
KW  - Rarity
Y1  - 2017
U6  - https://doi.org/10.1016/j.agee.2016.12.022
SN  - 0167-8809
SN  - 1873-2305
VL  - 237
SP  - 143
EP  - 153
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - THES
A1  - Martin, Susanne
T1  - Analytische Untersuchungen zum Opernschaffen des Komponisten Siegfried Matthus
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Maslin, Mark A.
A1  - Brierley, Chris M.
A1  - Milner, Alice M.
A1  - Shultz, Susanne
A1  - Trauth, Martin H.
A1  - Wilson, Katy E.
T1  - East African climate pulses and early human evolution
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
N2  - Current evidence suggests that all of the major events in hominin evolution have occurred in East Africa. Over the last two decades, there has been intensive work undertaken to understand African palaeoclimate and tectonics in order to put together a coherent picture of how the environment of East Africa has varied in the past. The landscape of East Africa has altered dramatically over the last 10 million years. It has changed from a relatively flat, homogenous region covered with mixed tropical forest, to a varied and heterogeneous environment, with mountains over 4 km high and vegetation ranging from desert to cloud forest. The progressive rifting of East Africa has also generated numerous lake basins, which are highly sensitive to changes in the local precipitation-evaporation regime. There is now evidence that the presence of precession-driven, ephemeral deep-water lakes in East Africa were concurrent with major events in hominin evolution. It seems the unusual geology and climate of East Africa created periods of highly variable local climate, which, it has been suggested could have driven hominin speciation, encephalisation and dispersal out of Africa. One example is the significant hominin speciation and brain expansion event at -1.8 Ma that seems to have been coeval with the occurrence of highly variable, extensive, deep-water lakes. This complex, climatically very variable setting inspired first the variability selection hypothesis, which was then the basis for the pulsed climate variability hypothesis. The newer of the two suggests that the long-term drying trend in East Africa was punctuated by episodes of short, alternating periods of extreme humidity and aridity. Both hypotheses, together with other key theories of climate-evolution linkages, are discussed in this paper. Though useful the actual evolution mechanisms, which led to early hominins are still unclear and continue to be debated. However, it is clear that an understanding of East African lakes and their palaeoclimate history is required to understand the context within which humans evolved and eventually left East Africa. (C) 2014 The Authors. Published by Elsevier Ltd.
KW  - Human evolution
KW  - East Africa
KW  - Palaeoclimatology
KW  - Palaeoliminology
KW  - Tectonics
KW  - Hominin
KW  - Orbital forcing
KW  - Cenozoic climate transitions
KW  - Pulsed climate variability hypothesis
Y1  - 2014
U6  - https://doi.org/10.1016/j.quascirev.2014.06.012
SN  - 0277-3791
VL  - 101
SP  - 1
EP  - 17
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Keller, Johannes
A1  - Catala-Lehnen, Philip
A1  - Huebner, Antje K.
A1  - Jeschke, Anke
A1  - Heckt, Timo
A1  - Lueth, Anja
A1  - Krause, Matthias
A1  - Koehne, Till
A1  - Albers, Joachim
A1  - Schulze, Jochen
A1  - Schilling, Sarah
A1  - Haberland, Michael
A1  - Denninger, Hannah
A1  - Neven, Mona
A1  - Hermans-Borgmeyer, Irm
A1  - Streichert, Thomas
A1  - Breer, Stefan
A1  - Barvencik, Florian
A1  - Levkau, Bodo
A1  - Rathkolb, Birgit
A1  - Wolf, Eckhard
A1  - Calzada-Wack, Julia
A1  - Neff, Frauke
A1  - Gailus-Durner, Valerie
A1  - Fuchs, Helmut
A1  - de Angelis, Martin Hrabe
A1  - Klutmann, Susanne
A1  - Tsourdi, Elena
A1  - Hofbauer, Lorenz C.
A1  - Kleuser, Burkhard
A1  - Chun, Jerold
A1  - Schinke, Thorsten
A1  - Amling, Michael
T1  - Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
JF  - Nature Communications
N2  - The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclast-specific inactivation of the murine CT receptor (CTR) causes increased bone formation. CT negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signalling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P(3). Finally, pharmacologic treatment with the nonselective S1P receptor agonist FTY720 causes increased bone formation in wild-type, but not in S1P(3)-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo and provides evidence for a pharmacologically exploitable crosstalk between osteoclasts and osteoblasts.
Y1  - 2014
U6  - https://doi.org/10.1038/ncomms6215
SN  - 2041-1723
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Lachmuth, Susanne
A1  - Durka, Walter
A1  - Schurr, Frank Martin
T1  - Differentiation of reproductive and competitive ability in the invaded range of Senecio inaequidens  the role of genetic Allee effects, adaptive and nonadaptive evolution
JF  - New phytologist : international journal of plant science
N2  - Genetic differentiation in the competitive and reproductive ability of invading populations can result from genetic Allee effects or r/K selection at the local or range-wide scale. However, the neutral relatedness of populations may either mask or falsely suggest adaptation and genetic Allee effects.
 In a common-garden experiment, we investigated the competitive and reproductive ability of invasive Senecio inaequidens populations that vary in neutral genetic diversity, population age and field vegetation cover. To account for population relatedness, we analysed the experimental results with 'animal models' adopted from quantitative genetics.
 Consistent with adaptive r/K differentiation at local scales, we found that genotypes from low-competition environments invest more in reproduction and are more sensitive to competition. By contrast, apparent effects of large-scale r/K differentiation and apparent genetic Allee effects can largely be explained by neutral population relatedness.
 Invading populations should not be treated as homogeneous groups, as they may adapt quickly to small-scale environmental variation in the invaded range. Furthermore, neutral population differentiation may strongly influence invasion dynamics and should be accounted for in analyses of common-garden experiments.
KW  - animal models
KW  - biological invasions
KW  - genetic Allee effects
KW  - interspecific competition
KW  - life history evolution
KW  - nonadaptive evolution
KW  - r and K selection
KW  - reproduction
Y1  - 2011
U6  - https://doi.org/10.1111/j.1469-8137.2011.03808.x
SN  - 0028-646X
VL  - 192
IS  - 2
SP  - 529
EP  - 541
PB  - Wiley-Blackwell
CY  - Malden
ER  - 
TY  - JOUR
A1  - Maslin, Mark A.
A1  - Shultz, Susanne
A1  - Trauth, Martin H.
T1  - A synthesis of the theories and concepts of early human evolution
JF  - Philosophical transactions of the Royal Society of London : B, Biological sciences
N2  - Current evidence suggests that many of the major events in hominin evolution occurred in East Africa. Hence, over the past two decades, there has been intensive work undertaken to understand African palaeoclimate and tectonics in order to put together a coherent picture of how the environment of Africa has varied over the past 10 Myr. A new consensus is emerging that suggests the unusual geology and climate of East Africa created a complex, environmentally very variable setting. This new understanding of East African climate has led to the pulsed climate variability hypothesis that suggests the long-term drying trend in East Africa was punctuated by episodes of short alternating periods of extreme humidity and aridity which may have driven hominin speciation, encephalization and dispersals out of Africa. This hypothesis is unique as it provides a conceptual framework within which other evolutionary theories can be examined: first, at macro-scale comparing phylogenetic gradualism and punctuated equilibrium; second, at a more focused level of human evolution comparing allopatric speciation, aridity hypothesis, turnover pulse hypothesis, variability selection hypothesis, Red Queen hypothesis and sympatric speciation based on sexual selection. It is proposed that each one of these mechanisms may have been acting on hominins during these short periods of climate variability, which then produce a range of different traits that led to the emergence of new species. In the case of Homo erectus (sensu lato), it is not just brain size that changes but life history (shortened inter-birth intervals, delayed development), body size and dimorphism, shoulder morphology to allow thrown projectiles, adaptation to long-distance running, ecological flexibility and social behaviour. The future of evolutionary research should be to create evidence-based meta-narratives, which encompass multiple mechanisms that select for different traits leading ultimately to speciation.
KW  - human evolution
KW  - East Africa
KW  - palaeoclimatology
KW  - hominin
KW  - pulsed climate variability framework
Y1  - 2015
U6  - https://doi.org/10.1098/rstb.2014.0064
SN  - 0962-8436
SN  - 1471-2970
VL  - 370
IS  - 1663
PB  - Royal Society
CY  - London
ER  - 
TY  - BOOK
A1  - Schwarzer, Ingo
A1  - Weiß-Saoumi, Said
A1  - Kittel, Roland
A1  - Friedrich, Tobias
A1  - Kaynak, Koraltan
A1  - Durak, Cemil
A1  - Isbarn, Andreas
A1  - Diestel, Jörg
A1  - Knittel, Jens
A1  - Franz, Marquart
A1  - Morra, Carlos
A1  - Stahnke, Susanne
A1  - Braband, Jens
A1  - Dittmann, Johannes
A1  - Griebel, Stephan
A1  - Krampf, Andreas
A1  - Link, Martin
A1  - Müller, Matthias
A1  - Radestock, Jens
A1  - Strub, Leo
A1  - Bleeke, Kai
A1  - Jehl, Leander
A1  - Kapitza, Rüdiger
A1  - Messadi, Ines
A1  - Schmidt, Stefan
A1  - Schwarz-Rüsch, Signe
A1  - Pirl, Lukas
A1  - Schmid, Robert
A1  - Friedenberger, Dirk
A1  - Beilharz, Jossekin Jakob
A1  - Boockmeyer, Arne
A1  - Polze, Andreas
A1  - Röhrig, Ralf
A1  - Schäbe, Hendrik
A1  - Thiermann, Ricky
T1  - RailChain
BT  - Abschlussbericht
N2  - The RailChain project designed, implemented, and experimentally evaluated a juridical recorder that is based on a distributed consensus protocol. That juridical blockchain recorder has been realized as distributed ledger on board the advanced TrainLab (ICE-TD 605 017) of Deutsche Bahn.
For the project, a consortium consisting of DB Systel, Siemens, Siemens Mobility, the Hasso Plattner Institute for Digital Engineering, Technische Universität Braunschweig, TÜV Rheinland InterTraffic, and Spherity has been formed. These partners not only concentrated competencies in railway operation, computer science, regulation, and approval, but also combined experiences from industry, research from academia, and enthusiasm from startups.
Distributed ledger technologies (DLTs) define distributed databases and express a digital protocol for transactions between business partners without the need for a trusted intermediary. The implementation of a blockchain with real-time requirements for the local network of a railway system (e.g., interlocking or train) allows to log data in the distributed system verifiably in real-time. For this, railway-specific assumptions can be leveraged to make modifications to standard blockchains protocols.
EULYNX and OCORA (Open CCS On-board Reference Architecture) are parts of a future European reference architecture for control command and signalling (CCS, Reference CCS Architecture – RCA). Both architectural concepts outline heterogeneous IT systems with components from multiple manufacturers. Such systems introduce novel challenges for the approved and safety-relevant CCS of railways which were considered neither for road-side nor for on-board systems so far. Logging implementations, such as the common juridical recorder on vehicles, can no longer be realized as a central component of a single manufacturer. All centralized approaches are in question.
The research project RailChain is funded by the mFUND program and gives practical evidence that distributed consensus protocols are a proper means to immutably (for legal purposes) store state information of many system components from multiple manufacturers. The results of RailChain have been published, prototypically implemented, and experimentally evaluated in large-scale field tests on the advanced TrainLab. At the same time, the project showed how RailChain can be integrated into the road-side and on-board architecture given by OCORA and EULYNX.
Logged data can now be analysed sooner and also their trustworthiness is being increased. This enables, e.g., auditable predictive maintenance, because it is ensured that data is authentic and unmodified at any point in time.
N2  - Das Projekt RailChain hat einen verteilten Juridical Recorder entworfen, implementiert und experimentell evaluiert, der auf einem echtzeitfähigen verteilten Konsensprotokoll basiert. Dieser Juridical Blockchain Recorder wurde als distributed ledger an Bord des advanced TrainLabs der Deutschen Bahn (ICE-TD 605 017) umgesetzt.
Für das Projekt hat sich ein Konsortium aus DB Systel, Siemens, Siemens Mobility, dem Hasso-Plattner-Institut für Digital Engineering, der Technischen Universität Braunschweig, sowie TÜV Rheinland InterTraffic und Spherity formiert und dabei Kompetenzen aus den Bereichen Bahnbetrieb, Informatik und Zulassungswesen gebündelt. Die Partner kombinieren Erfahrungen aus der Industrie und die akademische Forschung mit der Aufbruchstimmung aus dem Start-Up-Umfeld.
Distributed-Ledger-Technologien (DLTs) definieren verteilte Datenbanken und stellen ein digitales Protokoll für Transaktionen zwischen Geschäftspartnern dar, ohne dass ein Mittelsmann beteiligt sein müsste. Die Implementierung einer Blockchain mit Echtzeitanforderungen für das lokale Netzwerk einer Eisenbahnanlage (z. B. Stellwerk oder Zug) erlaubt es, die im verteilten System entstehenden Daten nachweislich in Echtzeit zu protokollieren. Dabei können eisenbahnspezifische Randbedingungen ausgenutzt werden, um Standard-Blockchain-Protokolle anzupassen.
EULYNX und OCORA (Open CCS On-board Reference Architecture) sind Bestandteile einer zukünftigen europäischen Referenzarchitektur für das Leit- und Sicherungssystem (Reference CCS Architecture – RCA, Control Command and Signalling – CCS). Beide Architekturkonzepte skizzieren herstellerübergreifende, komponentenbasierende heterogene IT-Systeme. Solche Systeme bergen neue Herausforderungen, die bislang im Kontext der zugelassenen, sicherheitsrelevanten Leit- und Sicherungstechnik der Bahn weder strecken- noch fahrzeugseitig adressiert werden mussten. Logbuch-Implementierungen, wie der gängige Juridical Recorder auf Fahrzeugen, können nun nicht mehr als zentrale Systemkomponente eines einzelnen Herstellers umgesetzt werden. Alle zentralisierten Lösungsansätze sind in Frage gestellt.
Das mFUND-geförderte Forschungsprojekt erbringt den praktischen Nachweis, dass Zustandsinformationen über eine Vielzahl von Systemkomponenten herstellerübergreifend und gerichtsfest mittels verteilten Konsensprotokollen gespeichert werden können. Ergebnisse von RailChain wurden publiziert, prototypisch implementiert und in großen Feldtests auf dem advanced TrainLab experimentell evaluiert. Gleichzeitig wurde aufgezeigt, wie sich RailChain in den mit OCORA und EULYNX vorgegebenen fahrzeug- und streckenseitigen Architekturentwurf integrieren lässt.
Daten können dadurch zeitnaher ausgewertet werden und gleichzeitig wird ihre Vertrauenswürdigkeit erhöht. Dies ermöglicht u. a. nachvollziehbare zustandsorientierte Wartung, denn es kann jederzeit sichergestellt werden, dass die Daten authentisch sind und auch nicht verändert wurden.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 152 
KW  - Distributed-Ledger-Technologie (DLT)
KW  - juridical recording
KW  - Konsensprotokolle
KW  - consensus protocols
KW  - Digitalisierung
KW  - digitalization
KW  - Bahnwesen
KW  - railways
KW  - Blockchain
KW  - asset management
KW  - selbstbestimmte Identitäten
KW  - self-sovereign identity
KW  - dezentrale Identitäten
KW  - decentral identities
KW  - überprüfbare Nachweise
KW  - verifiable credentials
KW  - Echtzeit
KW  - real-time
KW  - Standardisierung
KW  - standardization
KW  - Verlässlichkeit
KW  - dependability
KW  - Fehlertoleranz
KW  - fault tolerance
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-577409
SN  - 978-3-86956-550-7
SN  - 1613-5652
SN  - 2191-1665
IS  - 152
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Hermanns, Jolanda
A1  - Böhme, Katrin
A1  - Meyering, Meike
A1  - Fuchs, Isabelle
A1  - Wagner, Simon
A1  - Krauskopf, Karsten
A1  - Knigge, Michel
A1  - Rother, Stefanie
A1  - Tosch, Frank
A1  - Wendland, Mirko
A1  - Wulff, Peter
A1  - Mientus, Lukas
A1  - Nowak, Anna
A1  - Borowski, Andreas
A1  - Baer, Ella
A1  - Bosch, Jannis
A1  - Wilbert, Jürgen
A1  - Bräsel, Tim
A1  - Fenn, Monika
A1  - Kortenkamp, Ulrich
A1  - Kuzle, Ana
A1  - Reitz-Koncebovski, Karen
A1  - Burg, Paula
A1  - Lampart, Fabian
A1  - Leubner, Martin
A1  - Freitag-Hild, Britta
A1  - Bitmann, Anna
A1  - Reinhardt, Susanne
A1  - Roos, Jana
A1  - Hußner, Isabell
A1  - Börner, Dustin
A1  - Lazarides, Rebecca
A1  - Glowinski, Ingrid
A1  - Autenrieth, Marijke
A1  - Radke, Thea
A1  - Ehlert, Antje
A1  - Menke, Anne
A1  - Haupenthal, Anna
A1  - Schramm, Satyam Antonio
A1  - Kruse, Julia
A1  - Körner, Dorothea
A1  - Fischer, Jakob Thomas
A1  - Kayser, Daniela Niesta
ED  - Hermanns, Jolanda
T1  - PSI-Potsdam
BT  - Ergebnisbericht zu den Aktivitäten im Rahmen der Qualitätsoffensive Lehrerbildung (2019-2023)
T3  - Potsdamer Beiträge für Lehrkräftebildung und Bildungsforschung
N2  - An der Universität Potsdam wird seit 2015 im Rahmen der „Qualitätsoffensive Lehrerbildung“ das Projekt „Professionalisierung – Schulpraktische Studien – Inklusion“ (PSI-Potsdam) durchgeführt und am Zentrum für Lehrerbildung und Bildungsforschung (ZeLB) koordiniert. Zur ersten Projektförderphase (2015-2018) erschien der Band „PSI-Potsdam – Ergebnisbericht zu den Aktivitäten im Rahmen der Qualitätsoffensive Lehrerbildung (2015-2018)“ zum Auftakt der Reihe „Potsdamer Beiträge zur Lehrerbildung und Bildungsforschung“. 
Der vorliegende Band aus der gleichen Reihe gibt in den Kapiteln „Erhebungen“, „Lehrkonzepte“ und „Vernetzungen“ einen Überblick über alle Teilprojekte der zweiten Projektförderphase (2019-2023). Wissenschaftler:innen aus verschiedenen Fachdidaktiken, Fachwissenschaften sowie aus den Bildungswissenschaften und der Inklusionspädagogik haben im Rahmen des Projektes kooperiert. Sowohl praxisnahe Forschung als auch die Entwicklung neuer Lehrkonzepte sowie Strategien zur Vernetzung innerhalb der Lehrkräftebildung stehen im Fokus dieses Bandes. Die Praxisphasen, die im Rahmen des „Potsdamer Modells der Lehrerbildung“ eine zentrale Rolle spielen, wurden in einer großen Studie über alle Praxisphasen untersucht. 
Der Band gibt interessante Einblicke in die Ergebnisse der Teilprojekte und Anregungen sowohl für die eigene Forschung als auch für Entwicklungsarbeit wie zum Beispiel die Entwicklung neuer Lehrkonzepte. Herausgegeben wird dieser Band von PD Dr. Jolanda Hermanns (Gesamtkoordinatorin PSI-Potsdam und Chemiedidaktikerin).
T3  - Potsdamer Beiträge zur Lehrkräftebildung und Bildungsforschung - 3 
KW  - Lehrerbildung
KW  - Evaluation
KW  - Testinstrumente
KW  - Konzepte
KW  - Vernetzung
KW  - teacher education
KW  - evaluation
KW  - test instruments
KW  - concepts
KW  - networking
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-601875
SN  - 978-3-86956-568-2
SN  - 2626-3556
SN  - 2626-4722
IS  - 3
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Kachler, Katerina
A1  - Bailer, Maximilian
A1  - Heim, Lisanne
A1  - Schumacher, Fabian
A1  - Reichel, Martin
A1  - Holzinger, Corinna D.
A1  - Trump, Sonja
A1  - Mittler, Susanne
A1  - Monti, Juliana
A1  - Trufa, Denis I.
A1  - Rieker, Ralf J.
A1  - Hartmann, Arndt
A1  - Sirbu, Horia
A1  - Kleuser, Burkhard
A1  - Kornhuber, Johannes
A1  - Finotto, Susetta
T1  - Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma
JF  - Cancer research
N2  - The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal therapeutic target. In this study, we demonstrate elevated ASM activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC). RNAi-mediated attenuation of SMPD1 in human NSCLC cells rendered them resistant to serum starvation-induced apoptosis. In a murine model of lung adenocarcinoma, ASM deficiency reduced tumor development in a manner associated with significant enhancement of Th1-mediated and cytotoxic T-cell-mediated antitumor immunity. Our findings indicate that targeting ASM in NSCLC can act by tumor cell-intrinsic and-extrinsic mechanisms to suppress tumor cell growth, most notably by enabling an effective antitumor immune response by the host. (C) 2017 AACR.
Y1  - 2017
U6  - https://doi.org/10.1158/0008-5472.CAN-16-3313
SN  - 0008-5472
SN  - 1538-7445
VL  - 77
IS  - 21
SP  - 5963
EP  - 5976
PB  - American Association for Cancer Research
CY  - Philadelphia
ER  -