TY - THES A1 - Klein, Stephan T1 - Der Franchisevertrag BT - Das Leistungs- und Haftungsspektrum vom Beginn der Vertragsverhandlungen bis zur Vertragsbeendigung T2 - Nomos Universitätsschriften - Recht ; 877 Y1 - 2015 SN - 978-3-8487-2576-2 VL - 2015 PB - Nomos CY - Baden-Baden ER - TY - JOUR A1 - Bender, Stephan A1 - Banaschewski, Tobias A1 - Rößner, Veit A1 - Klein, Christoph A1 - Rietschel, Marcella A1 - Feige, Bernd A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Variability of single trial brain activation predicts fluctuations in reaction time JF - Biological psychology N2 - Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power). We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors. Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype. We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability. (C) 2015 Elsevier B.V. All rights reserved. KW - Event related potential KW - Haplotype KW - Intertrial coherence KW - Topographic consistency KW - Low frequency amplitude variability KW - Psychosocial stress Y1 - 2015 U6 - https://doi.org/10.1016/j.biopsycho.2015.01.013 SN - 0301-0511 SN - 1873-6246 VL - 106 SP - 50 EP - 60 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Gerbig, Stephan A1 - Nadjafi-Bösch, Marie A1 - Lanzl, Theresa A1 - Goeke, Henning A1 - Klein, Eckart A1 - Safoklov, Yury T1 - MenschenRechtsMagazin : Informationen | Meinungen | Analysen N2 - Aus dem Inhalt: - Kollektiv zum Recht: Der Kollektivbeschwerdemechanismus zur Europäischen Sozialcharta - 30 Jahre Ratifizierung der UN-Kinderrechte. Wie steht es um das Prinzip des Kindeswohlvorranges ? Zum Umsetzungsstand in Deutschland am Beispiel kindgerechter Justiz - EGMR, Vavřička u. a. ./. Tschechische Republik (47621/ 13), Urteil vom 8. April 2021 – Pflichtimpfungen für Kinder T3 - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen - 27.2022/1 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-540927 SN - 1434-2820 VL - 27 IS - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Bormann, Stephan A1 - Brunotte, Rene A1 - Bülow, Alexander A1 - Dörfler, Joachim A1 - Forner, Andreas A1 - Hafer, Gebhard A1 - Karth, Nina A1 - Klein, Ingo A1 - Kleinwächter, Lutz A1 - Lucht, Dietmar A1 - Peche, Norbert A1 - Schössler, Julia A1 - Weiß, Jürgen T1 - Die bbw Hochschule der Wirtschaft für die Wirtschaft Y1 - 2013 SN - 978-3-941880-76-4 PB - WeltTrends CY - Potsdam ER - TY - JOUR A1 - Peter, Lena A1 - Wendering, Désirée Jacqueline A1 - Schlickeiser, Stephan A1 - Hoffmann, Henrike A1 - Noster, Rebecca A1 - Wagner, Dimitrios Laurin A1 - Zarrinrad, Ghazaleh A1 - Münch, Sandra A1 - Picht, Samira A1 - Schulenberg, Sarah A1 - Moradian, Hanieh A1 - Mashreghi, Mir-Farzin A1 - Klein, Oliver A1 - Gossen, Manfred A1 - Roch, Toralf A1 - Babel, Nina A1 - Reinke, Petra A1 - Volk, Hans-Dieter A1 - Amini, Leila A1 - Schmueck-Henneresse, Michael T1 - Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients JF - Molecular therapy methods and clinical development N2 - Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that compromises their immune response to infections and vaccines. For this reason, SOT patients have a high risk of developing severe coronavirus disease 2019 (COVID-19) and an increased risk of death from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Moreover, the efficiency of immunotherapies and vaccines is reduced due to the constant immunosuppression in this patient group. Here, we propose adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, tacrolimus, for optimized performance in the immunosuppressed patient. Using a ribonucleoprotein approach of CRISPR-Cas9 technology, we have generated tacrolimus-resistant SARS-CoV-2-specific T cell products from convalescent donors and demonstrate their specificity and function through characterizations at the single-cell level, including flow cytometry, single-cell RNA (scRNA) Cellular Indexing of Transcriptomes and Epitopes (CITE), and T cell receptor (TCR) sequencing analyses. Based on the promising results, we aim for clinical validation of this approach in transplant recipients. Additionally, we propose a combinatory approach with tacrolimus, to prevent an overshooting immune response manifested as bystander T cell activation in the setting of severe COVID-19 immunopathology, and tacrolimus-resistant SARS-CoV-2-specific T cell products, allowing for efficient clearance of viral infection. Our strategy has the potential to prevent severe COVID-19 courses in SOT or autoimmunity settings and to prevent immunopathology while providing viral clearance in severe non-transplant COVID-19 cases. Y1 - 2022 U6 - https://doi.org/10.1016/j.omtm.2022.02.012 SN - 2329-0501 VL - 25 SP - 52 EP - 73 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Scherber, Christoph A1 - Eisenhauer, Nico A1 - Weisser, Wolfgang W. A1 - Schmid, Bernhard A1 - Voigt, Winfried A1 - Fischer, Markus A1 - Schukze, Ernst-Detlef A1 - Roscher, Christiane A1 - Weigelt, Alexandra A1 - Allan, Eric A1 - Beßler, Holger A1 - Bonkowski, Michael A1 - Buchmann, Nina A1 - Buscot, François A1 - Clement, Lars W. A1 - Ebeling, Anne A1 - Engels, Christof A1 - Halle, Stefan A1 - Kertscher, Ilona A1 - Klein, Alexandra-Maria A1 - Koller, Robert A1 - König, Stephan A1 - Kowalski, Esther A1 - Kummer, Volker A1 - Kuu, Annely A1 - Lange, Markus A1 - Lauterbach, Dirk T1 - Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment Y1 - 2010 UR - http://www.nature.com/nature/journal/v468/n7323/full/nature09492.html SN - 0028-0836 ER -