TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faiçal Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arrieta, M.
A1  - Aubert, Pierre
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Barnard, Michelle
A1  - Becherini, Yvonne
A1  - Tjus, Julia Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Bottcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Capasso, M.
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chevalier, J.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Condon, B.
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, Christoph
A1  - deWilt, P.
A1  - Djannati-Atai, Arache
A1  - Domainko, Wilfried
A1  - Donath, Axel
A1  - Dubus, Guillaume
A1  - Dutson, Kate
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, Stuart
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Funk, S.
A1  - Füßling, Matthias
A1  - Gabici, Stefano
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, Gianluca
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, Daniel
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, Daniela
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, Gilles
A1  - Hermann, G.
A1  - Hervet, Olivier
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, Alex
A1  - Jacholkowska, A.
A1  - Jamrozy, Marek
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, Felix
A1  - Jingo, M.
A1  - Jogler, Tobias
A1  - Jouvin, Lea
A1  - Jung-Richardt, Ira
A1  - Kastendieck, M. A.
A1  - Katarzynski, Krzysztof
A1  - Katz, Uli
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, Dmitry
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, Michael
A1  - Krayzel, F.
A1  - Kruger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, Jeanie
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, Thomas
A1  - Lorentz, M.
A1  - Lui, R.
A1  - Lypova, Iryna
A1  - Marandon, Vincent
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, Michael
A1  - Meintjes, Petrus Johannes
A1  - Menzler, U.
A1  - Meyer, Manuel
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - de Naurois, Mathieu
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, Hirokazu
A1  - Ohm, Stefan
A1  - Oettl, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, Marco
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, Helen
A1  - Prokhorov, Dmitry
A1  - Prokoph, Heike
A1  - Puehlhofer, Gerd
A1  - Punch, Michael
A1  - Quirrenbach, Andreas
A1  - Raab, S.
A1  - Reimer, Anita
A1  - Reimer, Olaf
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, Frank
A1  - Romoli, Carlo
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, David
A1  - Sanchez, David A.
A1  - Santangelo, Andrea
A1  - Sasaki, Manami
A1  - Schlickeiser, Reinhard
A1  - Schussler, F.
A1  - Schulz, Andreas
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, Felix
A1  - Spengler, G.
A1  - Spiess, F.
A1  - Stawarz, Lukasz
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, Martin
A1  - Trichard, C.
A1  - Tuffs, R.
A1  - van der Walt, Johan
A1  - van Eldik, Christopher
A1  - van Soelen, Brian
A1  - Vasileiadis, Georges
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, Jacco
A1  - Voisin, F.
A1  - Voelk, Heinrich J.
A1  - Vuillaume, Thomas
A1  - Wadiasingh, Z.
A1  - Wagner, Stefan J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, Alicja
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, Denis
A1  - Yang, R.
A1  - Zabalza, Victor
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Andreas
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywucka, Natalia
T1  - Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS
JF  - Physical review letters
N2  - The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevLett.117.111301
SN  - 0031-9007
SN  - 1079-7114
VL  - 117
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Aharonian, Felix A.
A1  - Ait Benkhali, Faical
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Arrieta, M.
A1  - Backes, Michael
A1  - Barnard, M.
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, D.
A1  - Bernhard, S.
A1  - Bernlöhr, Konrad
A1  - Blackwell, R.
A1  - Böttcher, Markus
A1  - Boisson, C.
A1  - Bolmont, Julien
A1  - Bonnefoy, S.
A1  - Bordas, Pol
A1  - Bregeon, J.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Büchele, M.
A1  - Bulik, Tomasz
A1  - Bylund, Tomas
A1  - Capasso, Massimo
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Cerruti, Matteo
A1  - Chakraborty, Nachiketa
A1  - Chandra, S.
A1  - Chaves, R. C. G.
A1  - Chen, A.
A1  - Colafrancesco, Sergio
A1  - Condon, B.
A1  - Davids, Isak
A1  - Deil, Christoph
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, Axel
A1  - Doroshenko, Victor
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Emery, G.
A1  - Ernenwein, J. -P.
A1  - Eschbach, Stefan
A1  - Fegan, S.
A1  - Fiasson, Armand
A1  - Fontaine, G.
A1  - Funk, Sebastian
A1  - Füßling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Gate, F.
A1  - Giavitto, Gianluca
A1  - Eisenacher Glawion, Dorit
A1  - Glicenstein, Jean-François
A1  - Gottschall, D.
A1  - Grondin, Marie-Hélène
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Heinzelmann, G.
A1  - Henri, Gilles
A1  - Hermann, G.
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hoischen, Clemens
A1  - Holch, Tim Lukas
A1  - Holler, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Iwasaki, H.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Jankowsky, David
A1  - Jankowsky, Felix
A1  - Jouvin, L.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzyński, Krzysztof
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, M.
A1  - Kruger, P. P.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lefaucheur, J.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, T.
A1  - Lorentz, M.
A1  - Lopez-Coto, R.
A1  - Lypova, I.
A1  - Malyshev, D.
A1  - Marandon, V.
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, M.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Perennes, C.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V.
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V.
A1  - Saito, S.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schussler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shilon, I.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Specovius, A.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steppa, Constantin Beverly
A1  - Takahashi, T.
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tibaldo, L.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Yang, R.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zywucka, N.
A1  - Cirelli, M.
A1  - Panci, P.
A1  - Sala, F.
A1  - Silk, J.
A1  - Taoso, M.
T1  - Searches for gamma-ray lines and 'pure WIMP' spectra from Dark Matter annihilations in dwarf galaxies with H.E.S.S.
JF  - Journal of cosmology and astroparticle physics
N2  - Dwarf spheroidal galaxies are among the most promising targets for detecting signals of Dark Matter (DM) annihilations. The H.E.S.S. experiment has observed five of these systems for a total of about 130 hours. The data are re-analyzed here, and, in the absence of any detected signals, are interpreted in terms of limits on the DM annihilation cross section. Two scenarios are considered: i) DM annihilation into mono-energetic gamma-rays and ii) DM in the form of pure WIMP multiplets that, annihilating into all electroweak bosons, produce a distinctive gamma-ray spectral shape with a high-energy peak at the DM mass and a lower-energy continuum. For case i), upper limits at 95% confidence level of about <sigma upsilon > less than or similar to 3 x 10(-25) cm(3) s(-1) are obtained in the mass range of 400 GeV to 1TeV. For case ii), the full spectral shape of the models is used and several excluded regions are identified, but the thermal masses of the candidates are not robustly ruled out.
KW  - dark matter detectors
KW  - dark matter experiments
KW  - dwarfs galaxies
KW  - gamma ray detectors
Y1  - 2018
U6  - https://doi.org/10.1088/1475-7516/2018/11/037
SN  - 1475-7516
IS  - 11
PB  - IOP Publishing Ltd. (Bristol)
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Lehn-Stefan, Angela
A1  - Peter, Andreas
A1  - Machann, Jürgen
A1  - Schick, Fritz
A1  - Randrianarisoa, Elko
A1  - Heni, Martin
A1  - Wagner, Robert
A1  - Birkenfeld, Andreas L.
A1  - Fritsche, Andreas
A1  - Schulze, Matthias Bernd
A1  - Stefan, Norbert
A1  - Kantartzis, Konstantinos
T1  - Impaired metabolic health and low cardiorespiratory fitness independently associate with subclinical atherosclerosis in obesity
JF  - The journal of clinical endocrinology & metabolism
N2  - Context
For a given body mass index (BMI), both impaired metabolic health (MH) and reduced cardiorespiratory fitness (CRF) associate with increased risk of cardiovascular disease (CVD). 

Objective
It remains unknown whether both risk phenotypes relate to CVD independently of each other, and whether these relationships differ in normal weight, overweight, and obese subjects. 

Methods
Data from 421 participants from the Tubingen Diabetes Family Study, who had measurements of anthropometrics, metabolic parameters, CRF (maximal aerobic capacity [VO2max]) and carotid intima-media thickness (cIMT), an early marker of atherosclerosis, were analyzed. Subjects were divided by BMI and MH status into 6 phenotypes. 

Results
In univariate analyses, older age, increased BMI, and a metabolic risk profile correlated positively, while insulin sensitivity and VO2max negatively with cIMT. In multivariable analyses in obese subjects, older age, male sex, lower VO2max (std. ss -0.21, P = 0.002) and impaired MH (std. ss 0.13, P = 0.02) were independent determinants of increased cIMT. After adjustment for age and sex, subjects with metabolically healthy obesity (MHO) had higher cIMT than subjects with metabolically healthy normal weight (MHNW; 0.59 +/- 0.009 vs 0.52 +/- 0.01 mm; P < 0.05). When VO2max was additionally included in this model, the difference in cIMT between MHO and MHNW groups became statistically nonsignificant (0.58 +/- 0.009 vs 0.56 +/- 0.02 mm; P > 0.05).

Conclusion
These data suggest that impaired MH and low CRF independently determine increased cIMT in obese subjects and that low CRF may explain part of the increased CVD risk observed in MHO compared with MHNW.
KW  - Metabolically healthy obesity
KW  - cardiorespiratory fitness
KW  - subclinical
KW  - atherosclerosis
KW  - obesity
KW  - carotid intima-media thickness
KW  - cardiovascular
KW  - disease
Y1  - 2022
U6  - https://doi.org/10.1210/clinem/dgac091
SN  - 0021-972X
SN  - 1945-7197
VL  - 107
IS  - 6
SP  - E2417
EP  - E2424
PB  - Endocrine Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Zacharias, Michael
A1  - Chen, Xuhui
A1  - Wagner, Stefan
T1  - Attenuation of TeV gamma-rays by the starlight photon field of the host galaxy
JF  - Monthly notices of the Royal Astronomical Society
N2  - The absorption of TeV gamma-ray photons produced in relativistic jets by surrounding soft photon fields is a long-standing problem of jet physics. In some cases, the most likely emission site close to the central black hole is ruled out because of the high opacity caused by strong optical and infrared photon sources, such as the broad-line region. Mostly neglected for jet modelling is the absorption of gamma-rays in the starlight photon field of the host galaxy. Analysing the absorption for arbitrary locations and observation angles of the gamma-ray emission site within the host galaxy, we find that the distance to the galaxy centre, the observation angle, and the distribution of starlight in the galaxy are crucial for the amount of absorption. We derive the absorption value for a sample of 20 TeV-detected blazars with a redshift z(r) < 0.2. The absorption value of the gamma-ray emission located in the galaxy centre may be as high as 20 per cent, with an average value of 6 per cent. This is important in order to determine the intrinsic blazar parameters. We see no significant trends in our sample between the degree of absorption and host properties, such as starlight emissivity, galactic size, half-light radius, and redshift. While the uncertainty of the spectral properties of the extragalactic background light exceeds the effect of absorption by stellar light from the host galaxy in distant objects, the latter is a dominant effect in nearby sources. It may also be revealed in a differential comparison of sources with similar redshifts.
KW  - opacity
KW  - radiation mechanisms: non-thermal
KW  - galaxies: active
KW  - gamma-rays: galaxies
Y1  - 2016
U6  - https://doi.org/10.1093/mnras/stw3032
SN  - 0035-8711
SN  - 1365-2966
VL  - 465
IS  - 3
SP  - 3767
EP  - 3774
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Hagen, Sven
A1  - Baumann, Tobias
A1  - Wagner, Hanna J.
A1  - Morath, Volker
A1  - Kaufmann, Beate
A1  - Fischer, Adrian
A1  - Bergmann, Stefan
A1  - Schindler, Patrick
A1  - Arndt, Katja Maren
A1  - Mueller, Kristian M.
T1  - Modular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy
JF  - Scientific reports
N2  - The pre-clinical and clinical development of viral vehicles for gene transfer increased in recent years, and a recombinant adeno-associated virus (rAAV) drug took center stage upon approval in the European Union. However, lack of standardization, inefficient purification methods and complicated retargeting limit general usability. We address these obstacles by fusing rAAV-2 capsids with two modular targeting molecules (DARPin or Affibody) specific for a cancer cell-surface marker (EGFR) while simultaneously including an affinity tag (His-tag) in a surface-exposed loop. Equipping these particles with genes coding for prodrug converting enzymes (thymidine kinase or cytosine deaminase) we demonstrate tumor marker specific transduction and prodrug-dependent apoptosis of cancer cells. Coding terminal and loop modifications in one gene enabled specific and scalable purification. Our genetic parts for viral production adhere to a standardized cloning strategy facilitating rapid prototyping of virus directed enzyme prodrug therapy (VDEPT).
Y1  - 2014
U6  - https://doi.org/10.1038/srep03759
SN  - 2045-2322
VL  - 4
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Ludwig, Joachim
A1  - Busse, Stefan
A1  - Linde, Klaus
A1  - Merkel, Torsten
A1  - Niewenhuis, Loek F. M.
A1  - Reihert, Claudia
A1  - Wittwer, Wolfgang
A1  - Polster, Andreas
A1  - Fricke, Werner
A1  - Scholz, Sylka
A1  - Wagner, Gabriele
A1  - Wernet, Andreas
A1  - Rehfeldt, Janine
A1  - Dreke, Claudia
A1  - Weis, Michael
ED  - Ludwig, Joachim
T1  - Interdisziplinarität als Chance
BT  - Wissenschaftstransfer und Beratung im lernenden Forschungszusammenhang
N2  - Interdisziplinarität und die damit verknüpften Fragen hat das Forschungsprojekt "Lernender Forschungszusammenhang" untersucht. Diese Publikation beschreibt ein Forschungskonzept, mit dem betriebliche Modernisierungsprojekte in fünf Großunternehmen interdisziplinär untersucht wurden. Die Forschungsergebnisse aus zwei dieser Unternehmen werden detailliert dargestellt. Der Leser kann entlang dokumentierter Forschungsergebnisse selbst nachvollziehen, in welcher Weise sich die Wissenschaftler aus unterschiedlichen Disziplinen lernend aufeinander bezogen haben.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - paper 269 
KW  - Unternehmen
KW  - Wissenschaftstransfer
KW  - Teamwork
KW  - Interdisziplinarität
KW  - Lerntheorie
KW  - Innovation
Y1  - 2008
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-74880
ER  - 
TY  - GEN
A1  - de Vera, Jean-Pierre Paul
A1  - Alawi, Mashal
A1  - Backhaus, Theresa
A1  - Baque, Mickael
A1  - Billi, Daniela
A1  - Boettger, Ute
A1  - Berger, Thomas
A1  - Bohmeier, Maria
A1  - Cockell, Charles
A1  - Demets, Rene
A1  - de la Torre Noetzel, Rosa
A1  - Edwards, Howell
A1  - Elsaesser, Andreas
A1  - Fagliarone, Claudia
A1  - Fiedler, Annelie
A1  - Foing, Bernard
A1  - Foucher, Frederic
A1  - Fritz, Jörg
A1  - Hanke, Franziska
A1  - Herzog, Thomas
A1  - Horneck, Gerda
A1  - Hübers, Heinz-Wilhelm
A1  - Huwe, Björn
A1  - Joshi, Jasmin Radha
A1  - Kozyrovska, Natalia
A1  - Kruchten, Martha
A1  - Lasch, Peter
A1  - Lee, Natuschka
A1  - Leuko, Stefan
A1  - Leya, Thomas
A1  - Lorek, Andreas
A1  - Martinez-Frias, Jesus
A1  - Meessen, Joachim
A1  - Moritz, Sophie
A1  - Moeller, Ralf
A1  - Olsson-Francis, Karen
A1  - Onofri, Silvano
A1  - Ott, Sieglinde
A1  - Pacelli, Claudia
A1  - Podolich, Olga
A1  - Rabbow, Elke
A1  - Reitz, Günther
A1  - Rettberg, Petra
A1  - Reva, Oleg
A1  - Rothschild, Lynn
A1  - Garcia Sancho, Leo
A1  - Schulze-Makuch, Dirk
A1  - Selbmann, Laura
A1  - Serrano, Paloma
A1  - Szewzyk, Ulrich
A1  - Verseux, Cyprien
A1  - Wadsworth, Jennifer
A1  - Wagner, Dirk
A1  - Westall, Frances
A1  - Wolter, David
A1  - Zucconi, Laura
T1  - Limits of life and the habitability of Mars
BT  - the ESA space experiment BIOMEX on the ISS
T2  - Astrobiology
N2  - BIOMEX (BIOlogy and Mars EXperiment) is an ESA/Roscosmos space exposure experiment housed within the exposure facility EXPOSE-R2 outside the Zvezda module on the International Space Station (ISS). The design of the multiuser facility supports-among others-the BIOMEX investigations into the stability and level of degradation of space-exposed biosignatures such as pigments, secondary metabolites, and cell surfaces in contact with a terrestrial and Mars analog mineral environment. In parallel, analysis on the viability of the investigated organisms has provided relevant data for evaluation of the habitability of Mars, for the limits of life, and for the likelihood of an interplanetary transfer of life (theory of lithopanspermia). In this project, lichens, archaea, bacteria, cyanobacteria, snow/permafrost algae, meristematic black fungi, and bryophytes from alpine and polar habitats were embedded, grown, and cultured on a mixture of martian and lunar regolith analogs or other terrestrial minerals. The organisms and regolith analogs and terrestrial mineral mixtures were then exposed to space and to simulated Mars-like conditions by way of the EXPOSE-R2 facility. In this special issue, we present the first set of data obtained in reference to our investigation into the habitability of Mars and limits of life. This project was initiated and implemented by the BIOMEX group, an international and interdisciplinary consortium of 30 institutes in 12 countries on 3 continents. Preflight tests for sample selection, results from ground-based simulation experiments, and the space experiments themselves are presented and include a complete overview of the scientific processes required for this space experiment and postflight analysis. The presented BIOMEX concept could be scaled up to future exposure experiments on the Moon and will serve as a pretest in low Earth orbit.
KW  - EXPOSE-R2
KW  - BIOMEX
KW  - Habitability
KW  - Limits of life
KW  - Extremophiles
KW  - Mars
Y1  - 2019
U6  - https://doi.org/10.1089/ast.2018.1897
SN  - 1531-1074
SN  - 1557-8070
VL  - 19
IS  - 2
SP  - 145
EP  - 157
PB  - Liebert
CY  - New Rochelle
ER  - 
TY  - JOUR
A1  - Willmann, Caroline
A1  - Heni, Martin
A1  - Linder, Katarzyna
A1  - Wagner, Robert
A1  - Stefan, Norbert
A1  - Machann, Jürgen
A1  - Schulze, Matthias Bernd
A1  - Joost, Hans-Georg
A1  - Haring, Hans-Ulrich
A1  - Fritsche, Andreas
T1  - Potential effects of reduced red meat compared with increased fiber intake on glucose metabolism and liver fat content
BT  - a randomized and controlled dietary intervention study
JF  - The American journal of clinical nutrition : a publication of the American Society for Nutrition, Inc.
N2  - Background: Epidemiological studies suggest that an increased red meat intake is associated with a higher risk of type 2 diabetes, whereas an increased fiber intake is associated with a lower risk. Objectives: We conducted an intervention study to investigate the effects of these nutritional factors on glucose and lipid metabolism, body-fat distribution, and liver fat content in subjects at increased risk of type 2 diabetes. Methods: This prospective, randomized, and controlled dietary intervention study was performed over 6 mo. All groups decreased their daily caloric intake by 400 kcal. The "control" group (N = 40) only had this requirement. The "no red meat" group (N = 48) in addition aimed to avoid the intake of red meat, and the "fiber" group (N = 44) increased intake of fibers to 40 g/d. Anthropometric parameters and frequently sampled oral glucose tolerance tests were performed before and after intervention. Body-fat mass and distribution, liver fat, and liver iron content were assessed by MRI and single voxel proton magnetic resonance spectroscopy. Results: Participants in all groups lost weight (mean 3.3 +/- 0.5 kg, P < 0.0001). Glucose tolerance and insulin sensitivity improved (P < 0.001), and body and visceral fat mass decreased in all groups (P < 0.001). These changes did not differ between groups. Liver fat content decreased significantly (P < 0.001) with no differences between the groups. The decrease in liver fat correlated with the decrease in ferritin during intervention (r(2) = 0.08, P = 0.0021). This association was confirmed in an independent lifestyle intervention study (Tuebingen Lifestyle Intervention Program, N = 229, P = 0.0084). Conclusions: Our data indicate that caloric restriction leads to a marked improvement in glucose metabolism and body-fat composition, including liver-fat content. The marked reduction in liver fat might be mediated via changes in ferritin levels. In the context of caloric restriction, there seems to be no additional beneficial impact of reduced red meat intake and increased fiber intake on the improvement in cardiometabolic risk parameters. This trial was registered at clinicaltrials.gov as NCT03231839.
KW  - type 2 diabetes
KW  - prevention
KW  - randomized controlled intervention study
KW  - nutritional factors
KW  - fiber
KW  - red meat
Y1  - 2019
U6  - https://doi.org/10.1093/ajcn/nqy307
SN  - 0002-9165
SN  - 1938-3207
VL  - 109
IS  - 2
SP  - 288
EP  - 296
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Wagner, Dieter
A1  - Huber, Stefan
T1  - Grundsatzfragen der Auslandsentsendung
Y1  - 1997
SN  - 3-540-61843-0
ER  - 
TY  - BOOK
A1  - Wagner, Dieter
A1  - Rohr, Stefan
A1  - Zander, Ernst
T1  - Gehälter und Trends im Personal- und Organisationswesen 1995/96
Y1  - 1995
PB  - r & p management consulting
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Wagner, Dieter
A1  - Huber, Stefan
T1  - Der Europäische Betriebsrat
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Wagner, Dieter
A1  - Huber, Stefan
T1  - Betriebsverfassungsrechtliche Beziehungen im internationalen Vergleich : industrial relations in Westeuropa und in den USA
Y1  - 1994
ER  - 
TY  - JOUR
A1  - Huber, Stefan
A1  - Wagner, Dieter
A1  - Leske, Mike
T1  - Prozeßorganisation : Ergebnisse eines Projektseminars an der Universität Potsdam in Zusammenarbeit mit Nutzfahrzeuge Ludwigsfelde GmbH (Mercedes AG, Ludwigsfelde)
JF  - Werkstattbericht
Y1  - 1994
VL  - 1995, 1
PB  - Univ.
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Sánchez, Alba
A1  - Thomas, Christine
A1  - Deeken, Friederike
A1  - Wagner, Sören
A1  - Klöppel, Stefan
A1  - Kentischer, Felix
A1  - von Arnim, Chrstine A. F.
A1  - Denkinger, Michael
A1  - Conzelmann, Lars O.
A1  - Biermann-Stallwitz, Janine
A1  - Joos, Stefanie
A1  - Sturm, Heidrun
A1  - Metz, Brigitte
A1  - Auer, Ramona
A1  - Skrobik, Yoanna
A1  - Eschweiler, Gerhard W.
A1  - Rapp, Michael A.
T1  - Patient safety, cost-effectiveness, and quality of life
BT  - reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults—study protocol for a stepped-wedge cluster randomized trial (PAWEL Study)
T2  - Postprints der Universität Potsdam Humanwissenschaftliche Reihe
N2  - Background

Postoperative delirium is a common disorder in older adults that is associated with higher morbidity and mortality, prolonged cognitive impairment, development of dementia, higher institutionalization rates, and rising healthcare costs. The probability of delirium after surgery increases with patients’ age, with pre-existing cognitive impairment, and with comorbidities, and its diagnosis and treatment is dependent on the knowledge of diagnostic criteria, risk factors, and treatment options of the medical staff. In this study, we will investigate whether a cross-sectoral and multimodal intervention for preventing delirium can reduce the prevalence of delirium and postoperative cognitive decline (POCD) in patients older than 70 years undergoing elective surgery. Additionally, we will analyze whether the intervention is cost-effective.

Methods

The study will be conducted at five medical centers (with two or three surgical departments each) in the southwest of Germany. The study employs a stepped-wedge design with cluster randomization of the medical centers. Measurements are performed at six consecutive points: preadmission, preoperative, and postoperative with daily delirium screening up to day 7 and POCD evaluations at 2, 6, and 12 months after surgery. Recruitment goals are to enroll 1500 patients older than 70 years undergoing elective operative procedures (cardiac, thoracic, vascular, proximal big joints and spine, genitourinary, gastrointestinal, and general elective surgery procedures.

Discussion

Results of the trial should form the basis of future standards for preventing delirium and POCD in surgical wards. Key aims are the improvement of patient safety and quality of life, as well as the reduction of the long-term risk of conversion to dementia. Furthermore, from an economic perspective, we expect benefits and decreased costs for hospitals, patients, and healthcare insurances.

Trial registration

German Clinical Trials Register, DRKS00013311. Registered on 10 November 2017.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 535 
KW  - Cross-sectoral care
KW  - Delirium prevention
KW  - Postoperative cognitive dysfunction
KW  - Dementia
KW  - Older patients
KW  - Elective surgery
KW  - Quality of life
KW  - Cost-effectiveness
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-424883
SN  - 1866-8364
IS  - 535
ER  - 
TY  - JOUR
A1  - Sánchez, Alba
A1  - Thomas, Christine
A1  - Deeken, Friederike
A1  - Wagner, Sören
A1  - Klöppel, Stefan
A1  - Kentischer, Felix
A1  - von Arnim, Chrstine A. F.
A1  - Denkinger, Michael
A1  - Conzelmann, Lars O.
A1  - Biermann-Stallwitz, Janine
A1  - Joos, Stefanie
A1  - Sturm, Heidrun
A1  - Metz, Brigitte
A1  - Auer, Ramona
A1  - Skrobik, Yoanna
A1  - Eschweiler, Gerhard W.
A1  - Rapp, Michael A.
T1  - Patient safety, cost-effectiveness, and quality of life
BT  - reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults—study protocol for a stepped-wedge cluster randomized trial (PAWEL Study)
JF  - Trials
N2  - Background

Postoperative delirium is a common disorder in older adults that is associated with higher morbidity and mortality, prolonged cognitive impairment, development of dementia, higher institutionalization rates, and rising healthcare costs. The probability of delirium after surgery increases with patients’ age, with pre-existing cognitive impairment, and with comorbidities, and its diagnosis and treatment is dependent on the knowledge of diagnostic criteria, risk factors, and treatment options of the medical staff. In this study, we will investigate whether a cross-sectoral and multimodal intervention for preventing delirium can reduce the prevalence of delirium and postoperative cognitive decline (POCD) in patients older than 70 years undergoing elective surgery. Additionally, we will analyze whether the intervention is cost-effective.

Methods

The study will be conducted at five medical centers (with two or three surgical departments each) in the southwest of Germany. The study employs a stepped-wedge design with cluster randomization of the medical centers. Measurements are performed at six consecutive points: preadmission, preoperative, and postoperative with daily delirium screening up to day 7 and POCD evaluations at 2, 6, and 12 months after surgery. Recruitment goals are to enroll 1500 patients older than 70 years undergoing elective operative procedures (cardiac, thoracic, vascular, proximal big joints and spine, genitourinary, gastrointestinal, and general elective surgery procedures.

Discussion

Results of the trial should form the basis of future standards for preventing delirium and POCD in surgical wards. Key aims are the improvement of patient safety and quality of life, as well as the reduction of the long-term risk of conversion to dementia. Furthermore, from an economic perspective, we expect benefits and decreased costs for hospitals, patients, and healthcare insurances.

Trial registration

German Clinical Trials Register, DRKS00013311. Registered on 10 November 2017.
KW  - Cross-sectoral care
KW  - Delirium prevention
KW  - Postoperative cognitive dysfunction
KW  - Dementia
KW  - Older patients
KW  - Elective surgery
KW  - Quality of life
KW  - Cost-effectiveness
Y1  - 2019
U6  - https://doi.org/10.1186/s13063-018-3148-8
SN  - 1468-6694
SN  - 1745-6215
SN  - 1468-6708
VL  - 20
IS  - 71
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Ehrig, Lukas
A1  - Wagner, Ann-Christin
A1  - Wolter, Heike
A1  - Correll, Christoph U.
A1  - Geisel, Olga
A1  - Konigorski, Stefan
T1  - FASDetect as a machine learning-based screening app for FASD in youth with ADHD
JF  - npj Digital Medicine
N2  - Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de.
KW  - Medical research
KW  - Psychiatric disorders
Y1  - 2023
U6  - https://doi.org/10.1038/s41746-023-00864-1
SN  - 2398-6352
VL  - 6
IS  - 1
PB  - Macmillan Publishers Limited
CY  - Basingstoke
ER  -