TY - JOUR A1 - Meyer, Sebastian Tobias A1 - Ptacnik, Robert A1 - Hillebrand, Helmut A1 - Bessler, Holger A1 - Buchmann, Nina A1 - Ebeling, Anne A1 - Eisenhauer, Nico A1 - Engels, Christof A1 - Fischer, Markus A1 - Halle, Stefan A1 - Klein, Alexandra-Maria A1 - Oelmann, Yvonne A1 - Roscher, Christiane A1 - Rottstock, Tanja A1 - Scherber, Christoph A1 - Scheu, Stefan A1 - Schmid, Bernhard A1 - Schulze, Ernst-Detlef A1 - Temperton, Vicky M. A1 - Tscharntke, Teja A1 - Voigt, Winfried A1 - Weigelt, Alexandra A1 - Wilcke, Wolfgang A1 - Weisser, Wolfgang W. T1 - Biodiversity-multifunctionality relationships depend on identity and number of measured functions JF - Nature Ecology & Evolution N2 - Biodiversity ensures ecosystem functioning and provisioning of ecosystem services, but it remains unclear how biodiversity-ecosystem multifunctionality relationships depend on the identity and number of functions considered. Here, we demonstrate that ecosystem multifunctionality, based on 82 indicator variables of ecosystem functions in a grassland biodiversity experiment, increases strongly with increasing biodiversity. Analysing subsets of functions showed that the effects of biodiversity on multifunctionality were stronger when more functions were included and that the strength of the biodiversity effects depended on the identity of the functions included. Limits to multifunctionality arose from negative correlations among functions and functions that were not correlated with biodiversity. Our findings underline that the management of ecosystems for the protection of biodiversity cannot be replaced by managing for particular ecosystem functions or services and emphasize the need for specific management to protect biodiversity. More plant species from the experimental pool of 60 species contributed to functioning when more functions were considered. An individual contribution to multifunctionality could be demonstrated for only a fraction of the species. Y1 - 2017 U6 - https://doi.org/10.1038/s41559-017-0391-4 SN - 2397-334X VL - 2 IS - 1 SP - 44 EP - 49 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Loprieno, Andrea A1 - Bousquet, Romain A1 - Bucher, Stefan A1 - Ceriani, Stefano A1 - Dalla Torre, Florian H. A1 - Fügenschuh, Bernhard A1 - Schmid, Stefan M. T1 - The valais units in Savoy (France) a key area for understanding the palaeogeography and the tectonic evolution of the Western Alps JF - International journal of earth sciences N2 - The Valais units in Savoy (Zone des BrSches de Tarentaise) have been re-mapped in great detail and are subject of combined stratigraphic, structural and petrological investigations summarized in this contribution. The sediments and rare relics of basement, together with Cretaceous age mafic and ultramafic rocks of the Valais palaeogeographical domain, represent the heavily deformed relics of the former distal European margin (External Valais units) and an ocean-continent transition (Internal Valais unit or Versoyen unit) that formed during rifting. This rifting led to the opening of the Valais ocean, a northern branch of the Alpine Tethys. Post-rift sediments referred to as "Valais trilogy" stratigraphically overlie both External and Internal Valais successions above an angular unconformity formed in Barremian to Aptian times, providing robust evidence for the timing of the opening of the Valais ocean. The Valais units in Savoy are part of a second and more external mid-Eocene high-pressure belt in the Alps that sutured the Brian double dagger onnais microcontinent to Europe. Top-N D1-deformation led to the formation of a nappe stack that emplaced the largely eclogite-facies Internal Valais unit (Versoyen) onto blueschist-facies External Valais units. The latter originally consisted of, from internal to external, the Petit St. Bernard unit, the Roc de l'Enfer unit, the MoA >> tiers unit and the Quermoz unit. Ongoing top-N D2-thrusting and folding substantially modified this nappe stack. Post 35 Ma D3 folding led to relatively minor modifications of the nappe stack within the Valais units but was associated with substantial top-WNW thrusting of the Valais units over the Dauphinois units along the Roselend thrust during W-directed indentation of the Adria block contributing to the formation of the arc of the Western Alps. KW - Alpine geology KW - Valais ocean KW - Palaeogeography KW - Structural geology KW - Tectonics KW - Metamorphism Y1 - 2011 U6 - https://doi.org/10.1007/s00531-010-0595-1 SN - 1437-3254 VL - 100 IS - 5 SP - 963 EP - 992 PB - Springer CY - New York ER - TY - JOUR A1 - Allan, Eric A1 - Weisser, Wolfgang W. A1 - Fischer, Markus A1 - Schulze, Ernst-Detlef A1 - Weigelt, Alexandra A1 - Roscher, Christiane A1 - Baade, Jussi A1 - Barnard, Romain L. A1 - Bessler, Holger A1 - Buchmann, Nina A1 - Ebeling, Anne A1 - Eisenhauer, Nico A1 - Engels, Christof A1 - Fergus, Alexander J. F. A1 - Gleixner, Gerd A1 - Gubsch, Marlen A1 - Halle, Stefan A1 - Klein, Alexandra-Maria A1 - Kertscher, Ilona A1 - Kuu, Annely A1 - Lange, Markus A1 - Le Roux, Xavier A1 - Meyer, Sebastian T. A1 - Migunova, Varvara D. A1 - Milcu, Alexandru A1 - Niklaus, Pascal A. A1 - Oelmann, Yvonne A1 - Pasalic, Esther A1 - Petermann, Jana S. A1 - Poly, Franck A1 - Rottstock, Tanja A1 - Sabais, Alexander C. W. A1 - Scherber, Christoph A1 - Scherer-Lorenzen, Michael A1 - Scheu, Stefan A1 - Steinbeiss, Sibylle A1 - Schwichtenberg, Guido A1 - Temperton, Vicky A1 - Tscharntke, Teja A1 - Voigt, Winfried A1 - Wilcke, Wolfgang A1 - Wirth, Christian A1 - Schmid, Bernhard T1 - A comparison of the strength of biodiversity effects across multiple functions JF - Oecologia N2 - In order to predict which ecosystem functions are most at risk from biodiversity loss, meta-analyses have generalised results from biodiversity experiments over different sites and ecosystem types. In contrast, comparing the strength of biodiversity effects across a large number of ecosystem processes measured in a single experiment permits more direct comparisons. Here, we present an analysis of 418 separate measures of 38 ecosystem processes. Overall, 45 % of processes were significantly affected by plant species richness, suggesting that, while diversity affects a large number of processes not all respond to biodiversity. We therefore compared the strength of plant diversity effects between different categories of ecosystem processes, grouping processes according to the year of measurement, their biogeochemical cycle, trophic level and compartment (above- or belowground) and according to whether they were measures of biodiversity or other ecosystem processes, biotic or abiotic and static or dynamic. Overall, and for several individual processes, we found that biodiversity effects became stronger over time. Measures of the carbon cycle were also affected more strongly by plant species richness than were the measures associated with the nitrogen cycle. Further, we found greater plant species richness effects on measures of biodiversity than on other processes. The differential effects of plant diversity on the various types of ecosystem processes indicate that future research and political effort should shift from a general debate about whether biodiversity loss impairs ecosystem functions to focussing on the specific functions of interest and ways to preserve them individually or in combination. KW - Bottom-up effects KW - Carbon cycling KW - Ecological synthesis KW - Ecosystem processes KW - Grasslands KW - Jena experiment KW - Nitrogen cycling Y1 - 2013 U6 - https://doi.org/10.1007/s00442-012-2589-0 SN - 0029-8549 VL - 173 IS - 1 SP - 223 EP - 237 PB - Springer CY - New York ER - TY - BOOK A1 - Beckmann, Susanne A1 - Bergmann, Valentin Friedrich A1 - Titos, Marcos Bolivar A1 - Brzezina, Claudia A1 - Elke, Katrin A1 - Falky, Paulina A1 - Jahnke, Nadja A1 - Janke, Stefan A1 - Kubitz, Robert A1 - Lesinski, Theresa A1 - Pelz, Klara A1 - Schmid, Vincent Leonhard A1 - Schulz, Laura A1 - Spiller, Friedrich A1 - Weskamp, Madeleine A1 - Wille, Johanna A1 - Zenk, Johannes ED - Bossen, Anja T1 - Wege entstehen beim Gehen BT - Ein Leitfaden für Musicalarbeit in der Schule N2 - Musicalarbeit in der Schule, vom Mini-Musical bis hin zu groß angelegten Schulmusicals, erfreut sich sowohl bei Schülerinnen und Schülern als auch bei Musiklehrkräften großer Beliebtheit und eines oftmals außerordentlichen, teils auch unterschätzten Engagements. Dessen ungeachtet gibt es nur wenig musikdidaktische Fachliteratur zu diesem Thema und es liegen bislang nur wenige Forschungsarbeiten vor, die wegweisend für die Umsetzung von Musicalprojekten an Schulen sind. Auch in der Musiklehrerbildung spielt Musicalarbeit nur eine marginale Rolle. Die vorliegende Publikation möchte dazu beitragen, diese Lücke zu verringern. Sie ist das Ergebnis des Masterseminars „Musicalarbeit in der Schule“ am Lehrstuhl für Musikpädagogik und Musikdidaktik der Universität Potsdam, das begleitend zur künstlerischen Erarbeitung des Musicals „Elion“ durch Studierende der Universität Potsdam im Sommersemester 2018 stattfand. Im Zentrum des Seminars standen pädagogische sowie methodisch-didaktische Fragestellungen in den Bereichen Gesang, Choreografie und Theaterarbeit. Des Weiteren wurden Möglichkeiten und pädagogische Potenziale fachübergreifenden und fächerverbindenden Arbeitens erörtert. Zu diesem Seminar wurden Musicalexperten aus verschiedenen schulischen Kontexten eingeladen, die den Studierenden Einblicke in ihre langjährigen Praxiserfahrungen gewährten und ihre Erfahrungen zur Diskussion stellten. Die vorliegende Publikation wurde abschließend von den Seminarteilnehmern selbst erarbeitet und stellt eine Zusammenfassung des Seminars dar. Sie versteht sich als Entscheidungshilfe für oder gegen Musicalarbeit in der Schule und als Leitfaden für den Einstieg in die Praxis. KW - Musical KW - Musiktheater KW - Musiktheaterarbeit KW - Musikunterricht KW - Musikpädagogik KW - musical KW - music theatre KW - music education KW - music in school KW - music lessons Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-434284 SN - 978-3-86956-443-2 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Vigorito, Carlo A1 - Abreu, Ana A1 - Ambrosetti, Marco A1 - Belardinelli, Romualdo A1 - Corrà, Ugo A1 - Cupples, Margaret A1 - Davos, Constantinos H. A1 - Hoefer, Stefan A1 - Iliou, Marie-Christine A1 - Schmid, Jean-Paul A1 - Völler, Heinz A1 - Doherty, Patrick T1 - Frailty and cardiac rehabilitation BT - a call to action from the EAPC Cardiac Rehabilitation Section T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Frailty is a geriatric syndrome characterised by a vulnerability status associated with declining function of multiple physiological systems and loss of physiological reserves. Two main models of frailty have been advanced: the phenotypic model (primary frailty) or deficits accumulation model (secondary frailty), and different instruments have been proposed and validated to measure frailty. However measured, frailty correlates to medical outcomes in the elderly, and has been shown to have prognostic value for patients in different clinical settings, such as in patients with coronary artery disease, after cardiac surgery or transvalvular aortic valve replacement, in patients with chronic heart failure or after left ventricular assist device implantation. The prevalence, clinical and prognostic relevance of frailty in a cardiac rehabilitation setting has not yet been well characterised, despite the increasing frequency of elderly patients in cardiac rehabilitation, where frailty is likely to influence the onset, type and intensity of the exercise training programme and the design of tailored rehabilitative interventions for these patients. Therefore, we need to start looking for frailty in elderly patients entering cardiac rehabilitation programmes and become more familiar with some of the tools to recognise and evaluate the severity of this condition. Furthermore, we need to better understand whether exercise-based cardiac rehabilitation may change the course and the prognosis of frailty in cardiovascular patients. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 406 KW - frailty KW - cardiac rehabilitation KW - elderly Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-405172 IS - 406 ER - TY - JOUR A1 - Schwidrowski, Kirstin A1 - Schmid, Thilo A1 - Brück, Rainer A1 - Freischlad, Stefan A1 - Schubert, Sigrid A1 - Stechert, Peer T1 - Mikrosystemverständnis im Hochschulstudium – Ein praktikumsorientierter Ansatz JF - Commentarii informaticae didacticae : (CID) N2 - Mit hochschuldidaktischer Forschung zur Informatik soll aus einem traditionellen Hardwarepraktikum ein attraktives Entwurfs- und Anwendungspraktikum für Mikrosysteme (MSE) werden, das ein unverzichtbarer Bestandteil des Informatikstudiums ist. Diese Neugestaltung der Lehre wurde aufgrund des Bologna-Prozesses und der zunehmenden Präsenz multifunktionaler eingebetteter Mikrosysteme (EMS) im täglichen Leben notwendig. Ausgehend von einer Lehrveranstaltungsanalyse werden Vorschläge für die Kompetenzorientierung abgeleitet. Es wird gezeigt, dass für eine Verfeinerung des Ansatzes ein wissenschaftlich fundiertes Verständnis der erwarteten Kompetenzen erforderlich ist. Für den aufgezeigten Forschungsbedarf werden ein Ansatz zur Beschreibung des notwendigen Mikrosystemverständnisses dargestellt und Forschungsfelder zu Aspekten des Kompetenzbegriffs im Kontext der Lehrveranstaltung beschrieben. KW - Informatik KW - Ausbildung KW - Didaktik KW - Hochschuldidaktik Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-29601 SN - 1868-0844 SN - 2191-1940 IS - 1 SP - 131 EP - 142 ER - TY - JOUR A1 - Scharf, Anke A1 - Handy, Mark R. A1 - Ziemann, Martin Andreas A1 - Schmid, Stefan M. T1 - Peak-temperature patterns of polyphase metamorphism resulting from accretion, subduction and collision (eastern Tauern Window, European Alps) - a study with Raman microspectroscopy on carbonaceous material (RSCM) JF - Journal of metamorphic geology N2 - Raman microspectroscopy on carbonaceous material (RSCM) from the eastern Tauern Window indicates contrasting peak-temperature patterns in three different fabric domains, each of which underwent a poly-metamorphic orogenic evolution: Domain 1 in the northeastern Tauern Window preserves oceanic units (Glockner Nappe System, Matrei Zone) that attained peak temperatures (T-p) of 350-480 degrees C following Late Cretaceous to Palaeogene nappe stacking in an accretionary wedge. Domain 2 in the central Tauern Window experienced T-p of 500-535 degrees C that was attained either within an exhumed Palaeogene subduction channel or during Oligocene Barrovian-type thermal overprinting within the Alpine collisional orogen. Domain 3 in the Eastern Tauern Subdome has a peak-temperature pattern that resulted from Eo-Oligocene nappe stacking of continental units derived from the distal European margin. This pattern acquired its presently concentric pattern in Miocene time due to post-nappe doming and extensional shearing along the Katschberg Shear Zone System (KSZS). T-p values in the largest (Hochalm) dome range from 612 degrees C in its core to 440 degrees C at its rim. The maximum peak-temperature gradient (70 degrees Ckm(-1)) occurs along the eastern margin of this dome where mylonitic shearing of the Katschberg Normal Fault (KNF) significantly thinned the Subpenninic- and Penninic nappe pile, including the pre-existing peak-temperature gradient. KW - doming KW - Eastern Alps KW - high-pressure and Barrovian-type metamorphism KW - orogen-parallel extension KW - peak-temperature pattern KW - Raman microspectroscopy Y1 - 2013 U6 - https://doi.org/10.1111/jmg.12048 SN - 0263-4929 VL - 31 IS - 8 SP - 863 EP - 880 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Handy, Mark R. A1 - Schmid, Stefan M. A1 - Bousquet, Romain A1 - Kissling, Eduard A1 - Bernoulli, Daniel T1 - Reconciling plate-tectonic reconstructions of Alpine Tethys with the geological-geophysical record of spreading and subduction in the Alps N2 - A new reconstruction of Alpine Tethys combines plate-kinematic modelling with a wealth of geological data and seismic tomography to shed light on its evolution, from sea-floor spreading through subduction to collision in the Alps. Unlike previous models, which relate the fate of Alpine Tethys solely to relative motions of Africa, Iberia and Europe during opening of the Atlantic, our reconstruction additionally invokes independent microplates whose motions are constrained primarily by the geological record. The motions of these microplates (Adria, Iberia, Alcapia, Alkapecia, and Tiszia) relative to both Africa and Europe during Late Cretaceous to Cenozoic time involved the subduction of remnant Tethyan basins during the following three stages that are characterized by contrasting plate motions and driving forces: (1) 131-84 Ma intra-oceanic subduction of the Ligurian part of Alpine Tethys attached to Iberia coincided with Eo-alpine orogenesis in the Alcapia microplate, north of Africa. These events were triggered primarily by foundering of the older (170-131 Ma) Neotethyan subduction slab along the NE margin of the composite African-Adriatic plate; subduction was linked by a sinistral transform system to E-W opening of the Valais part of Alpine Tethys; (2) 84-35 Ma subduction of primarily the Piemont and Valais parts of Alpine Tethys which were then attached to the European plate beneath the overriding African and later Adriatic plates. NW translation of Adria with respect to Africa was accommodated primarily by slow widening of the Ionian Sea; (3) 35 Ma-Recent rollback subduction of the Ligurian part of Alpine Tethys coincided with Western Alpine orogenesis and involved the formation of the Gibraltar and Calabrian arcs. Rapid subduction and arc formation were driven primarily by the pull of the gravitationally unstable, retreating Adriatic and African slabs during slow convergence of Africa and Europe. The upper European-Iberian plate stretched to accommodate this slab retreat in a very mobile fashion, while the continental core of the Adriatic microplate acted as a rigid indenter within the Alpine collisional zone. The subducted lithosphere in this reconstruction can be correlated with slab material imaged by seismic tomography beneath the Alps and Apennines, as well as beneath parts of the Pannonian Basin, the Adriatic Sea, the Ligurian Sea, and the Western Mediterranean. The predicted amount of subducted lithosphere exceeds the estimated volume of slab material residing at depth by some 10-30%, indicating that parts of slabs may be superposed within the mantle transition zone and/or that some of this subducted lithosphere became seismically transparent. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/00128252 U6 - https://doi.org/10.1016/j.earscirev.2010.06.002 SN - 0012-8252 ER - TY - JOUR A1 - Berger, Alfons A1 - Bousquet, Romain A1 - Engi, Martin A1 - Janots, Emilie A1 - Rubatto, Daniela A1 - Schmid, Stefan A1 - Wiederkehr, Michael T1 - Transport of heat and mass in a Barrovian belt : what do we know from nature? Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00167037 U6 - https://doi.org/10.1016/j.gca.2009.05.002 SN - 0016-7037 ER - TY - JOUR A1 - Wiederkehr, Michael A1 - Bousquet, Romain A1 - Ziemann, Martin Andreas A1 - Berger, Alfons A1 - Schmid, Stefan M. T1 - 3-D assessment of peak-metamorphic conditions by Raman spectroscopy of carbonaceous material an example from the margin of the Lepontine dome (Swiss Central Alps) JF - International journal of earth sciences N2 - This study monitors regional changes in the crystallinity of carbonaceous matter (CM) by applying Micro-Raman spectroscopy to a total of 214 metasediment samples (largely so-called Bundnerschiefer) dominantly metamorphosed under blueschist- to amphibolite-facies conditions. They were collected within the northeastern margin of the Lepontine dome and easterly adjacent areas of the Swiss Central Alps. Three-dimensional mapping of isotemperature contours in map and profile views shows that the isotemperature contours associated with the Miocene Barrow-type Lepontine metamorphic event cut across refolded nappe contacts, both along and across strike within the northeastern margin of the Lepontine dome and adjacent areas. Further to the northeast, the isotemperature contours reflect temperatures reached during the Late Eocene subduction-related blueschist-facies event and/or during subsequent near-isothermal decompression; these contours appear folded by younger, large-scale post-nappe-stacking folds. A substantial jump in the recorded maximum temperatures across the tectonic contact between the frontal Adula nappe complex and surrounding metasediments indicates that this contact accommodated differential tectonic movement of the Adula nappe with respect to the enveloping Bundnerschiefer after maximum temperatures were reached within the northern Adula nappe, i.e. after Late Eocene time. KW - HP-metamorphism KW - Barrovian metamorphism KW - Graphitization KW - Metasediments KW - Micro-Raman spectroscopy KW - Central Alps Y1 - 2011 U6 - https://doi.org/10.1007/s00531-010-0622-2 SN - 1437-3254 VL - 100 IS - 5 SP - 1029 EP - 1063 PB - Springer CY - New York ER - TY - JOUR A1 - Berger, Alfons A1 - Schmid, Stefan M. A1 - Engi, Martin A1 - Bousquet, Romain A1 - Wiederkehr, Michael T1 - Mechanisms of mass and heat transport during Barrovian metamorphism: A discussion based on field evidence from the Central Alps (Switzerland/northern Italy) JF - Tectonics N2 - Tectonic and metamorphic data for the Central Alps (Switzerland/Italy) are used to discuss this classic example of a Barrovian metamorphic terrain, notably the evolution of its thermal structure in space and time. Available P-T-t data indicate variable contributions of advective and conductive heat transport during collision and subsequent cooling and exhumation. Some areas experienced a prolonged period of partial melting while other areas, at the same time, show but moderate heating. The Barrow-type metamorphic field gradient observed in the final orogen is the result of two distinct tectonic processes, with their related advective and conductive heat transport processes. The two tectonic processes are (1) accretion of material within a subduction channel related to decompression and emplacement of high-pressure units in the middle crust and (2) wedging and related nappe formation in the continental lower plate. The second process postdates the first one. Wedging and underthrusting of continental lower plate material produces heat input into lower crustal levels, and this process is responsible for predominantly conductive heat transport in the overlying units. The interacting processes lead to different maximum temperatures at different times, producing the final Barrovian metamorphic field gradient. The south experienced rapid cooling, whereas the north shows moderate cooling rates. This discrepancy principally reflects differences in the temperature distribution in the deeper crust prior to cooling. Differences in the local thermal gradient that prevailed before the cooling also determined the relationships between cooling rate and exhumation rate in the different areas. Citation: Berger, A., S. M. Schmid, M. Engi, R. Bousquet, and M. Wiederkehr (2011), Mechanisms of mass and heat transport during Barrovian metamorphism: A discussion based on field evidence from the Central Alps (Switzerland/northern Italy), Tectonics, 30, TC1007, doi:10.1029/2009TC002622. Y1 - 2011 U6 - https://doi.org/10.1029/2009TC002622 SN - 0278-7407 VL - 30 IS - 2 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Vigorito, Carlo A1 - Abreu, Ana A1 - Ambrosetti, Marco A1 - Belardinelli, Romualdo A1 - Corra, Ugo A1 - Cupples, Margaret A1 - Davos, Constantinos H. A1 - Hoefer, Stefan A1 - Iliou, Marie-Christine A1 - Schmid, Jean-Paul A1 - Völler, Heinz A1 - Doherty, Patrick T1 - Frailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Frailty is a geriatric syndrome characterised by a vulnerability status associated with declining function of multiple physiological systems and loss of physiological reserves. Two main models of frailty have been advanced: the phenotypic model (primary frailty) or deficits accumulation model (secondary frailty), and different instruments have been proposed and validated to measure frailty. However measured, frailty correlates to medical outcomes in the elderly, and has been shown to have prognostic value for patients in different clinical settings, such as in patients with coronary artery disease, after cardiac surgery or transvalvular aortic valve replacement, in patients with chronic heart failure or after left ventricular assist device implantation. The prevalence, clinical and prognostic relevance of frailty in a cardiac rehabilitation setting has not yet been well characterised, despite the increasing frequency of elderly patients in cardiac rehabilitation, where frailty is likely to influence the onset, type and intensity of the exercise training programme and the design of tailored rehabilitative interventions for these patients. Therefore, we need to start looking for frailty in elderly patients entering cardiac rehabilitation programmes and become more familiar with some of the tools to recognise and evaluate the severity of this condition. Furthermore, we need to better understand whether exercise-based cardiac rehabilitation may change the course and the prognosis of frailty in cardiovascular patients. KW - Frailty KW - cardiac rehabilitation KW - elderly Y1 - 2017 U6 - https://doi.org/10.1177/2047487316682579 SN - 2047-4873 SN - 2047-4881 VL - 24 SP - 577 EP - 590 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Wiederkehr, Michael A1 - Sudo, Masafumi A1 - Bousquet, Romain A1 - Berger, Alfons A1 - Schmid, Stefan M. T1 - Alpine orogenic evolution from subduction to collisional thermal overprint : the Ar-40/Ar-39 age constraints from the Valaisan Ocean, central Alps N2 - The investigated HP/LT metasedimentary units of the Valaisan and adjacent European domains occupy a key position in the Alpine belt for understanding the transition from early subduction-related HP/LT metamorphism to collision-related Barrovian overprint and the evolution of mountain belts in general. The timing of high-pressure metamorphism, subsequent retrogression and following Barrow-type overprint was studied by Ar-40/Ar-39 dating of biotite and several white mica generations that are well characterized in terms of mineral chemistry, texture and associated mineral assemblages. Four distinct age populations of white mica record peak pressure conditions (42-40 Ma) and several stages of subsequent retrograde metamorphic evolution (36-25 Ma). Biotite isotopic analyses yield consistent apparent ages that cluster around 18-16 Ma for the Barrow-type thermal overprint. The recorded isotopic data reveal a significant time gap in the order of some 20 Ma between subduction-related HP/LT metamorphism and collision-related Barrovian overprint, supporting the notion of a polymetamorphic evolution associated with a bimodal P-T path. Y1 - 2009 UR - http://www.agu.org/journals/tc/ U6 - https://doi.org/10.1029/2009tc002496 SN - 0278-7407 ER - TY - JOUR A1 - Scharf, Andreas A1 - Handy, Mark R. A1 - Schmid, Stefan M. A1 - Favaro, Silvia A1 - Sudo, Masafumi A1 - Schuster, Ralf A1 - Hammerschmidt, Konrad T1 - Grain-size effects on the closure temperature of white mica in a crustal-scale extensional shear - zone - Implications of in-situ Ar-40/Ar-39 laser-ablation of white mica for dating shearing and cooling (Tauern Window, Eastern Alps) JF - Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth N2 - In-situ Ar-40/Ar-39 laser ablation dating of white-mica grains was performed on samples from the footwall of a crustal-scale extensional fault (Katschberg Normal Fault; KNF) that accommodated eastward orogen-parallel displacement of Alpine orogenic crust in the eastern part of the Tauern Window. This dating yields predominantly cooling ages ranging from 31 to 13 Myr, with most ages clustering between 21 and 17 Myr. Folded white micas that predate the main Katschberg foliation yield, within error, the same ages as white-mica grains that overgrow this foliation. However, the absolute ages of both generations are older at the base (20 Myr) where their grain size is larger (300-500 mu m), than at the top and adjacent to the hangingwall (17 Myr) of this shear zone where grain size is smaller (<100-300 mu m). This fining-upward trend of white-mica grain size within the KNF is associated with a reduction of the closure temperature from the base (similar to 445 degrees C) to the top (<400 degrees C) and explains the counter-intuitive trend of downward-increasing age of cooling in the footwall. The new data show that rapid cooling within the KNF of the eastern Tauern Window started sometime before 21 Myr according to the Ar-40/Ar-39 white-mica cooling ages and between 25-21 Myr according to the new Rb/Sr white-mica ages, i.e., shortly after the attainment of the thermal peak in the Tauern Window at similar to 25 Myr ago. These new data, combined with literature data, support earlier cooling in the eastern part of then Tauem Window than in the western part by some 3-5 Myr. (C) 2016 Elsevier B.V. All rights reserved. KW - Eastern Alps KW - Ar-40/Ar-39 laser ablation KW - Closure temperature KW - Orogen-parallel lateral extrusion KW - Rapid exhumation/cooling Y1 - 2016 U6 - https://doi.org/10.1016/j.tecto.2016.02.014 SN - 0040-1951 SN - 1879-3266 VL - 674 SP - 210 EP - 226 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Schwarzer, Ingo A1 - Weiß-Saoumi, Said A1 - Kittel, Roland A1 - Friedrich, Tobias A1 - Kaynak, Koraltan A1 - Durak, Cemil A1 - Isbarn, Andreas A1 - Diestel, Jörg A1 - Knittel, Jens A1 - Franz, Marquart A1 - Morra, Carlos A1 - Stahnke, Susanne A1 - Braband, Jens A1 - Dittmann, Johannes A1 - Griebel, Stephan A1 - Krampf, Andreas A1 - Link, Martin A1 - Müller, Matthias A1 - Radestock, Jens A1 - Strub, Leo A1 - Bleeke, Kai A1 - Jehl, Leander A1 - Kapitza, Rüdiger A1 - Messadi, Ines A1 - Schmidt, Stefan A1 - Schwarz-Rüsch, Signe A1 - Pirl, Lukas A1 - Schmid, Robert A1 - Friedenberger, Dirk A1 - Beilharz, Jossekin Jakob A1 - Boockmeyer, Arne A1 - Polze, Andreas A1 - Röhrig, Ralf A1 - Schäbe, Hendrik A1 - Thiermann, Ricky T1 - RailChain BT - Abschlussbericht N2 - The RailChain project designed, implemented, and experimentally evaluated a juridical recorder that is based on a distributed consensus protocol. That juridical blockchain recorder has been realized as distributed ledger on board the advanced TrainLab (ICE-TD 605 017) of Deutsche Bahn. For the project, a consortium consisting of DB Systel, Siemens, Siemens Mobility, the Hasso Plattner Institute for Digital Engineering, Technische Universität Braunschweig, TÜV Rheinland InterTraffic, and Spherity has been formed. These partners not only concentrated competencies in railway operation, computer science, regulation, and approval, but also combined experiences from industry, research from academia, and enthusiasm from startups. Distributed ledger technologies (DLTs) define distributed databases and express a digital protocol for transactions between business partners without the need for a trusted intermediary. The implementation of a blockchain with real-time requirements for the local network of a railway system (e.g., interlocking or train) allows to log data in the distributed system verifiably in real-time. For this, railway-specific assumptions can be leveraged to make modifications to standard blockchains protocols. EULYNX and OCORA (Open CCS On-board Reference Architecture) are parts of a future European reference architecture for control command and signalling (CCS, Reference CCS Architecture – RCA). Both architectural concepts outline heterogeneous IT systems with components from multiple manufacturers. Such systems introduce novel challenges for the approved and safety-relevant CCS of railways which were considered neither for road-side nor for on-board systems so far. Logging implementations, such as the common juridical recorder on vehicles, can no longer be realized as a central component of a single manufacturer. All centralized approaches are in question. The research project RailChain is funded by the mFUND program and gives practical evidence that distributed consensus protocols are a proper means to immutably (for legal purposes) store state information of many system components from multiple manufacturers. The results of RailChain have been published, prototypically implemented, and experimentally evaluated in large-scale field tests on the advanced TrainLab. At the same time, the project showed how RailChain can be integrated into the road-side and on-board architecture given by OCORA and EULYNX. Logged data can now be analysed sooner and also their trustworthiness is being increased. This enables, e.g., auditable predictive maintenance, because it is ensured that data is authentic and unmodified at any point in time. N2 - Das Projekt RailChain hat einen verteilten Juridical Recorder entworfen, implementiert und experimentell evaluiert, der auf einem echtzeitfähigen verteilten Konsensprotokoll basiert. Dieser Juridical Blockchain Recorder wurde als distributed ledger an Bord des advanced TrainLabs der Deutschen Bahn (ICE-TD 605 017) umgesetzt. Für das Projekt hat sich ein Konsortium aus DB Systel, Siemens, Siemens Mobility, dem Hasso-Plattner-Institut für Digital Engineering, der Technischen Universität Braunschweig, sowie TÜV Rheinland InterTraffic und Spherity formiert und dabei Kompetenzen aus den Bereichen Bahnbetrieb, Informatik und Zulassungswesen gebündelt. Die Partner kombinieren Erfahrungen aus der Industrie und die akademische Forschung mit der Aufbruchstimmung aus dem Start-Up-Umfeld. Distributed-Ledger-Technologien (DLTs) definieren verteilte Datenbanken und stellen ein digitales Protokoll für Transaktionen zwischen Geschäftspartnern dar, ohne dass ein Mittelsmann beteiligt sein müsste. Die Implementierung einer Blockchain mit Echtzeitanforderungen für das lokale Netzwerk einer Eisenbahnanlage (z. B. Stellwerk oder Zug) erlaubt es, die im verteilten System entstehenden Daten nachweislich in Echtzeit zu protokollieren. Dabei können eisenbahnspezifische Randbedingungen ausgenutzt werden, um Standard-Blockchain-Protokolle anzupassen. EULYNX und OCORA (Open CCS On-board Reference Architecture) sind Bestandteile einer zukünftigen europäischen Referenzarchitektur für das Leit- und Sicherungssystem (Reference CCS Architecture – RCA, Control Command and Signalling – CCS). Beide Architekturkonzepte skizzieren herstellerübergreifende, komponentenbasierende heterogene IT-Systeme. Solche Systeme bergen neue Herausforderungen, die bislang im Kontext der zugelassenen, sicherheitsrelevanten Leit- und Sicherungstechnik der Bahn weder strecken- noch fahrzeugseitig adressiert werden mussten. Logbuch-Implementierungen, wie der gängige Juridical Recorder auf Fahrzeugen, können nun nicht mehr als zentrale Systemkomponente eines einzelnen Herstellers umgesetzt werden. Alle zentralisierten Lösungsansätze sind in Frage gestellt. Das mFUND-geförderte Forschungsprojekt erbringt den praktischen Nachweis, dass Zustandsinformationen über eine Vielzahl von Systemkomponenten herstellerübergreifend und gerichtsfest mittels verteilten Konsensprotokollen gespeichert werden können. Ergebnisse von RailChain wurden publiziert, prototypisch implementiert und in großen Feldtests auf dem advanced TrainLab experimentell evaluiert. Gleichzeitig wurde aufgezeigt, wie sich RailChain in den mit OCORA und EULYNX vorgegebenen fahrzeug- und streckenseitigen Architekturentwurf integrieren lässt. Daten können dadurch zeitnaher ausgewertet werden und gleichzeitig wird ihre Vertrauenswürdigkeit erhöht. Dies ermöglicht u. a. nachvollziehbare zustandsorientierte Wartung, denn es kann jederzeit sichergestellt werden, dass die Daten authentisch sind und auch nicht verändert wurden. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 152 KW - Distributed-Ledger-Technologie (DLT) KW - juridical recording KW - Konsensprotokolle KW - consensus protocols KW - Digitalisierung KW - digitalization KW - Bahnwesen KW - railways KW - Blockchain KW - asset management KW - selbstbestimmte Identitäten KW - self-sovereign identity KW - dezentrale Identitäten KW - decentral identities KW - überprüfbare Nachweise KW - verifiable credentials KW - Echtzeit KW - real-time KW - Standardisierung KW - standardization KW - Verlässlichkeit KW - dependability KW - Fehlertoleranz KW - fault tolerance Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-577409 SN - 978-3-86956-550-7 SN - 1613-5652 SN - 2191-1665 IS - 152 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Carpinteiro, Alexander A1 - Becker, Katrin Anne A1 - Japtok, Lukasz A1 - Hessler, Gabriele A1 - Keitsch, Simone A1 - Pozgajova, Miroslava A1 - Schmid, Kurt W. A1 - Adams, Constantin A1 - Müller, Stefan A1 - Kleuser, Burkhard A1 - Edwards, Michael J. A1 - Grassme, Heike A1 - Helfrich, Iris A1 - Gulbins, Erich T1 - Regulation of hematogenous tumor metastasis by acid sphingomyelinase JF - EMBO molecular medicine N2 - Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread. Transplanting wild-type platelets into Asm-deficient mice reinstated tumor metastasis. Likewise, Asm-deficient mice were protected from hematogenous MT/ret melanoma metastasis to the spleen in a mouse model of spontaneous tumor metastasis. Human and mouse melanoma cells triggered activation and release of platelet secretory Asm, in turn leading to ceramide formation, clustering, and activation of 51 integrins on melanoma cells finally leading to adhesion of the tumor cells. Clustering of integrins by applying purified Asm or C-16 ceramide to B16F10 melanoma cells before intravenous injection restored trapping of tumor cells in the lung in Asm-deficient mice. This effect was revertable by arginine-glycine-aspartic acid peptides, which are known inhibitors of integrins, and by antibodies neutralizing 1 integrins. These findings indicate that melanoma cells employ platelet-derived Asm for adhesion and metastasis. KW - acid sphingomyelinase KW - ceramide KW - integrins KW - platelets KW - tumor-metastasis Y1 - 2015 SN - 1757-4676 SN - 1757-4684 VL - 7 IS - 6 SP - 714 EP - 734 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Frieler, Katja A1 - Schauberger, Bernhard A1 - Arneth, Almut A1 - Balkovic, Juraj A1 - Chryssanthacopoulos, James A1 - Deryng, Delphine A1 - Elliott, Joshua A1 - Folberth, Christian A1 - Khabarov, Nikolay A1 - Müller, Christoph A1 - Olin, Stefan A1 - Pugh, Thomas A. M. A1 - Schaphoff, Sibyll A1 - Schewe, Jacob A1 - Schmid, Erwin A1 - Warszawski, Lila A1 - Levermann, Anders T1 - Understanding the weather signal in national crop-yield variability JF - Earths future N2 - Year-to-year variations in crop yields can have major impacts on the livelihoods of subsistence farmers and may trigger significant global price fluctuations, with severe consequences for people in developing countries. Fluctuations can be induced by weather conditions, management decisions, weeds, diseases, and pests. Although an explicit quantification and deeper understanding of weather-induced crop-yield variability is essential for adaptation strategies, so far it has only been addressed by empirical models. Here, we provide conservative estimates of the fraction of reported national yield variabilities that can be attributed to weather by state-of-the-art, process-based crop model simulations. We find that observed weather variations can explain more than 50% of the variability in wheat yields in Australia, Canada, Spain, Hungary, and Romania. For maize, weather sensitivities exceed 50% in seven countries, including the United States. The explained variance exceeds 50% for rice in Japan and South Korea and for soy in Argentina. Avoiding water stress by simulating yields assuming full irrigation shows that water limitation is a major driver of the observed variations in most of these countries. Identifying the mechanisms leading to crop-yield fluctuations is not only fundamental for dampening fluctuations, but is also important in the context of the debate on the attribution of loss and damage to climate change. Since process-based crop models not only account for weather influences on crop yields, but also provide options to represent human-management measures, they could become essential tools for differentiating these drivers, and for exploring options to reduce future yield fluctuations. Y1 - 2017 U6 - https://doi.org/10.1002/2016EF000525 SN - 2328-4277 VL - 5 SP - 605 EP - 616 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Scherber, Christoph A1 - Eisenhauer, Nico A1 - Weisser, Wolfgang W. A1 - Schmid, Bernhard A1 - Voigt, Winfried A1 - Fischer, Markus A1 - Schukze, Ernst-Detlef A1 - Roscher, Christiane A1 - Weigelt, Alexandra A1 - Allan, Eric A1 - Beßler, Holger A1 - Bonkowski, Michael A1 - Buchmann, Nina A1 - Buscot, François A1 - Clement, Lars W. A1 - Ebeling, Anne A1 - Engels, Christof A1 - Halle, Stefan A1 - Kertscher, Ilona A1 - Klein, Alexandra-Maria A1 - Koller, Robert A1 - König, Stephan A1 - Kowalski, Esther A1 - Kummer, Volker A1 - Kuu, Annely A1 - Lange, Markus A1 - Lauterbach, Dirk T1 - Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment Y1 - 2010 UR - http://www.nature.com/nature/journal/v468/n7323/full/nature09492.html SN - 0028-0836 ER - TY - JOUR A1 - Meyer, Sebastian T. A1 - Ebeling, Anne A1 - Eisenhauer, Nico A1 - Hertzog, Lionel A1 - Hillebrand, Helmut A1 - Milcu, Alexandru A1 - Pompe, Sven A1 - Abbas, Maike A1 - Bessler, Holger A1 - Buchmann, Nina A1 - De Luca, Enrica A1 - Engels, Christof A1 - Fischer, Markus A1 - Gleixner, Gerd A1 - Hudewenz, Anika A1 - Klein, Alexandra-Maria A1 - de Kroon, Hans A1 - Leimer, Sophia A1 - Loranger, Hannah A1 - Mommer, Liesje A1 - Oelmann, Yvonne A1 - Ravenek, Janneke M. A1 - Roscher, Christiane A1 - Rottstock, Tanja A1 - Scherber, Christoph A1 - Scherer-Lorenzen, Michael A1 - Scheu, Stefan A1 - Schmid, Bernhard A1 - Schulze, Ernst-Detlef A1 - Staudler, Andrea A1 - Strecker, Tanja A1 - Temperton, Vicky A1 - Tscharntke, Teja A1 - Vogel, Anja A1 - Voigt, Winfried A1 - Weigelt, Alexandra A1 - Wilcke, Wolfgang A1 - Weisser, Wolfgang W. T1 - Effects of biodiversity strengthen over time as ecosystem functioning declines at low and increases at high biodiversity JF - Ecosphere : the magazine of the International Ecology University KW - biodiversity ecosystem functioning (BEF) KW - ecosystem processes KW - grassland KW - mechanism KW - plant productivity KW - plant species richness KW - temporal effects KW - trophic interactions Y1 - 2016 U6 - https://doi.org/10.1002/ecs2.1619 SN - 2150-8925 VL - 7 PB - Wiley-Blackwell CY - Hoboken ER -