TY  - JOUR
A1  - Prommer, Hans-Ulrich
A1  - Maurer, Johannes
A1  - von Websky, Karoline
A1  - Freise, Christian
A1  - Sommer, Kerstin
A1  - Nasser, Hamoud
A1  - Samapati, Rudi
A1  - Reglin, Bettina
A1  - Guimaraes, Pedro
A1  - Pries, Axel Radlach
A1  - Querfeld, Uwe
T1  - Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis
JF  - Scientific reports
N2  - Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1 alpha, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-23663-1
SN  - 2045-2322
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - THES
A1  - Sommer, Bettina
T1  - Holocaust-Erinnerung und arabisch-israelischer Konflikt : Wechselwirkungen in der israelischen Öffentlichkeit 2000 – 2006
T1  - Holocaust-commemoration and the Arab-Israeli conflict : interactions in the Israeli public 2000 - 2006
N2  - In der vorliegenden Diplomarbeit wird untersucht, welchen Einfluss kollektive Erinnerung und offizielle Geschichtsschreibung auf die Bildung kollektiver Identitäten haben und speziell auf Israel bezogen, wie und ob aus der Erinnerungskultur an die Shoah Handlungsmotivationen im gegenwärtigen Konflikt abgeleitet und diese mit Bezug auf die Shoah legitimiert werden. Der Focus im theoretischen Bereich der Arbeit liegt in erster Linie auf der Entstehung kultureller Gedächtnisse und kollektiver Identitäten speziell auf den Dynamiken, die sie in Großkollektiven wie Nationen entwickeln, in denen mehrere Erinnerungsdiskurse und Gruppenidentitäten der gesamtgesellschaftlichen Integration bedürfen. Des weiteren wird der Frage nachgegangen in welchem Verhältnis moderne Geschichtswissenschaft und kollektive Erinnerung zueinander stehen. Ist eine echte Trennung von Geschichtswissenschaft und kollektiver Erinnerung in der gelebten Realität einer Gruppe überhaupt möglich, vor allem, wenn ihr Gegenstand eine zentrale Rolle im kulturellen Gedächtnis des Kollektivs einnimmt und exponiert zur Identitätskonstruktion herangezogen wird, wie die Shoah in Israel? Hier schließt sich die Rezeption der Entwicklung der Shoah-Erinnerung in Israel von der Gründung des Staates bis heute an. Untersucht wird hier, welchen Stellenwert die Erinnerung an die Shoah zu den verschiedenen Zeiten im Selbstbild der jüdischen Israelis einnahm und warum sie immer wieder Eingang in tagespolitische Diskurse und Entscheidungen fand. Kommt es in Zeiten der äußeren Bedrohung durch Selbstmordanschläge oder andere außen- und innenpolitischen Unsicherheitssituationen zu einer verstärkten Projektion der Shoah-Erinnerung auf die Gegenwart? Dieser Frage wird im dritten Teil der Arbeit an Hand einer Zeitungsanalyse nachgegangen.
N2  - This diploma thesis analyses the impact of the collective remembrance and the official historiography on the collective memory. The specific question concerning Israel is asking if the actions in the ongoing conflict are derived and motivated from the cultural remembrance of the Shoah and how are these actions legitimized in reference to the Shoah. The theoretical focus of this paper lies in the genesis of the cultural commemorations and collective identities, specifically on the dynamics that have developed in large groups such as in nations, where different discourses of remembrance and group-identities require integration to society as a whole. Furthermore the question how historical science and collective memory relate to one another is pursued. Is it possible that there is a definite distinction between the historiography and the collective memory of the living group’s reality, particularly when the subject plays a major roll in the cultural recommendation of the collective society, such as the Shoah in modern Israel? This is followed by an analysis of how the remembrance of the Shoah has developed in Israel from its foundation as a state to modern times. The specific subject of interest here is the relative importance of how the remembrance of the Shoah has affected the self-perception of Jewish Israelis and why it consistently penetrates current political affairs and their decisions. Can there be found an increased projection of the Shoah remembrance in the present in situations of inner- and outer political interference, for example by suicide-bombings or in times of external and internal uncertainty? This question is pursued in the last part of this paper through newspaper analysis.
KW  - kollektives Gedächtnis
KW  - Holocaust
KW  - Israel
KW  - collective memory
KW  - Holocaust
KW  - Israel
Y1  - 2007
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-18635
ER  - 
TY  - JOUR
A1  - Mettler, Tabea
A1  - Mühlhaus, Timo
A1  - Hemme, Dorothea
A1  - Schöttler, Mark Aurel
A1  - Rupprecht, Jens
A1  - Idoine, Adam
A1  - Veyel, Daniel
A1  - Pal, Sunil Kumar
A1  - Yaneva-Roder, Liliya
A1  - Winck, Flavia Vischi
A1  - Sommer, Frederik
A1  - Vosloh, Daniel
A1  - Seiwert, Bettina
A1  - Erban, Alexander
A1  - Burgos, Asdrubal
A1  - Arvidsson, Samuel Janne
A1  - Schoenfelder, Stephanie
A1  - Arnold, Anne
A1  - Guenther, Manuela
A1  - Krause, Ursula
A1  - Lohse, Marc
A1  - Kopka, Joachim
A1  - Nikoloski, Zoran
A1  - Müller-Röber, Bernd
A1  - Willmitzer, Lothar
A1  - Bock, Ralph
A1  - Schroda, Michael
A1  - Stitt, Mark
T1  - Systems analysis of the response of photosynthesis, metabolism, and growth to an increase in irradiance in the photosynthetic model organism chlamydomonas reinhardtii
JF  - The plant cell
N2  - We investigated the systems response of metabolism and growth after an increase in irradiance in the nonsaturating range in the algal model Chlamydomonas reinhardtii. In a three-step process, photosynthesis and the levels of metabolites increased immediately, growth increased after 10 to 15 min, and transcript and protein abundance responded by 40 and 120 to 240 min, respectively. In the first phase, starch and metabolites provided a transient buffer for carbon until growth increased. This uncouples photosynthesis from growth in a fluctuating light environment. In the first and second phases, rising metabolite levels and increased polysome loading drove an increase in fluxes. Most Calvin-Benson cycle (CBC) enzymes were substrate-limited in vivo, and strikingly, many were present at higher concentrations than their substrates, explaining how rising metabolite levels stimulate CBC flux. Rubisco, fructose-1,6-biosphosphatase, and seduheptulose-1,7-bisphosphatase were close to substrate saturation in vivo, and flux was increased by posttranslational activation. In the third phase, changes in abundance of particular proteins, including increases in plastidial ATP synthase and some CBC enzymes, relieved potential bottlenecks and readjusted protein allocation between different processes. Despite reasonable overall agreement between changes in transcript and protein abundance (R-2 = 0.24), many proteins, including those in photosynthesis, changed independently of transcript abundance.
Y1  - 2014
U6  - https://doi.org/10.1105/tpc.114.124537
SN  - 1040-4651
SN  - 1532-298X
VL  - 26
IS  - 6
SP  - 2310
EP  - 2350
PB  - American Society of Plant Physiologists
CY  - Rockville
ER  -