TY  - JOUR
A1  - Geng, Christian
A1  - Turk, Alice
A1  - Scobbie, James M.
A1  - Macmartin, Cedric
A1  - Hoole, Philip
A1  - Richmond, Korin
A1  - Wrench, Alan
A1  - Pouplier, Marianne
A1  - Bard, Ellen Gurman
A1  - Campbell, Ziggy
A1  - Dickie, Catherine
A1  - Dubourg, Eddie
A1  - Hardcastle, William
A1  - Kainada, Evia
A1  - King, Simon
A1  - Lickley, Robin
A1  - Nakai, Satsuki
A1  - Renals, Steve
A1  - White, Kevin
A1  - Wiegand, Ronny
T1  - Recording speech articulation in dialogue - evaluating a synchronized double electromagnetic articulography setup
JF  - Journal of phonetics
N2  - We demonstrate the workability of an experimental facility that is geared towards the acquisition of articulatory data from a variety of speech styles common in language use, by means of two synchronized electromagnetic articulography (EMA) devices. This approach synthesizes the advantages of real dialogue settings for speech research with a detailed description of the physiological reality of speech production. We describe the facility's method for acquiring synchronized audio streams of two speakers and the system that enables communication among control room technicians, experimenters and participants. Further, we demonstrate the feasibility of the approach by evaluating problems inherent to this specific setup: The first problem is the accuracy of temporal synchronization of the two EMA machines, the second is the severity of electromagnetic interference between the two machines. Our results suggest that the synchronization method used yields an accuracy of approximately 1 ms. Electromagnetic interference was derived from the complex-valued signal amplitudes. This dependent variable was analyzed as a function of the recording status - i.e. on/off - of the interfering machine's transmitters. The intermachine distance was varied between 1 m and 8.5 m. Results suggest that a distance of approximately 6.5 m is appropriate to achieve data quality comparable to that of single speaker recordings.
Y1  - 2013
U6  - https://doi.org/10.1016/j.wocn.2013.07.002
SN  - 0095-4470
VL  - 41
IS  - 6
SP  - 421
EP  - 431
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Michalik-Onichimowska, Aleksandra
A1  - Kern, Simon
A1  - Riedel, Jens
A1  - Panne, Ulrich
A1  - King, Rudibert
A1  - Maiwald, Michael
T1  - "Click" analytics for "click" chemistry - A simple method for calibration-free evaluation of online NMR spectra
JF  - Journal of magnetic resonance
N2  - Driven mostly by the search for chemical syntheses under biocompatible conditions, so called "click" chemistry rapidly became a growing field of research. The resulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via comparably straightforward and robust analysis techniques possessing short set-up times. Here, we report on a fast and reliable calibration-free online NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement of H-1 spectra with a time interval of 20 s per spectrum, and a robust, fully automated algorithm to interpret the obtained data. As a proof-of-concept, the thiol-ene coupling between N-boc cysteine methyl ester and ally] alcohol was conducted in a variety of non-deuterated solvents while its time-resolved behaviour was characterized with step tracer experiments. Overlapping signals in online spectra during thiol-ene coupling could be deconvoluted with a spectral model using indirect hard modeling and were subsequently converted to either molar ratios (using a calibration free approach) or absolute concentrations (using 1-point calibration). For various solvents the kinetic constant k for pseudo-first order reaction was estimated to be 3.9 h(-1) at 25 degrees C. The obtained results were compared with direct integration of non-overlapping signals and showed good agreement with the implemented mass balance. (C) 2017 Elsevier Inc. All rights reserved.
KW  - NMR spectroscopy
KW  - Reaction monitoring
KW  - Automated data evaluation
KW  - Thiol-ene click chemistry
Y1  - 2017
U6  - https://doi.org/10.1016/j.jmr.2017.02.018
SN  - 1090-7807
SN  - 1096-0856
VL  - 277
SP  - 154
EP  - 161
PB  - Elsevier
CY  - San Diego
ER  -