TY - THES A1 - Otto, Sebastian T1 - Zulassungskonforme und schnelle massenspektronomische Analytik und präklinische Pharmakokinetik neuer Wirkstoffkandidaten Y1 - 2013 CY - Potsdam ER - TY - JOUR A1 - Mahlow, Sebastian A1 - Hejazi, Mahdi A1 - Kuhnert, Franziska A1 - Garz, Andreas A1 - Brust, Henrike A1 - Baumann, Otto A1 - Fettke, Jörg T1 - Phosphorylation of transitory starch by -glucan, water dikinase during starch turnover affects the surface properties and morphology of starch granules JF - New phytologist : international journal of plant science N2 - Glucan, water dikinase (GWD) is a key enzyme of starch metabolism but the physico-chemical properties of starches isolated from GWD-deficient plants and their implications for starch metabolism have so far not been described. Transgenic Arabidopsis thaliana plants with reduced or no GWD activity were used to investigate the properties of starch granules. In addition, using various in vitro assays, the action of recombinant GWD, -amylase, isoamylase and starch synthase 1 on the surface of native starch granules was analysed. The internal structure of granules isolated from GWD mutant plants is unaffected, as thermal stability, allomorph, chain length distribution and density of starch granules were similar to wild-type. However, short glucan chain residues located at the granule surface dominate in starches of transgenic plants and impede GWD activity. A similarly reduced rate of phosphorylation by GWD was also observed in potato tuber starch fractions that differ in the proportion of accessible glucan chain residues at the granule surface. A model is proposed to explain the characteristic morphology of starch granules observed in GWD transgenic plants. The model postulates that the occupancy rate of single glucan chains at the granule surface limits accessibility to starch-related enzymes. KW - Arabidopsis thaliana KW - glucan KW - water dikinase (GWD) KW - sex1-8 KW - starch granule surface KW - starch phosphorylation Y1 - 2014 U6 - https://doi.org/10.1111/nph.12801 SN - 0028-646X SN - 1469-8137 VL - 203 IS - 2 SP - 495 EP - 507 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Thieken, Annegret A1 - Kienzler, Sarah A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Mühr, Bernhard A1 - Müller, Meike A1 - Otto, Antje A1 - Petrow, Theresia A1 - Pisi, Sebastian A1 - Schröter, Kai T1 - Review of the flood risk management system in Germany after the major flood in 2013 N2 - Widespread flooding in June 2013 caused damage costs of €6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of €11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all stakeholders. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 294 KW - August 2002 flood KW - Central Europe KW - Floods Directive KW - June 2013 flood KW - governance KW - risk management cycle Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-100600 SN - 1866-8372 ER - TY - BOOK A1 - Thieken, Annegret A1 - Bessel, Tina A1 - Callsen, Ines A1 - Falter, Daniela A1 - Hasan, Issa A1 - Kienzler, Sarah A1 - Kox, Thomas A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Matthias, Max A1 - Meyer, Volker A1 - Mühr, Bernhard A1 - Müller, Meike A1 - Otto, Antje A1 - Pech, Ina A1 - Petrow, Theresia A1 - Pisi, Sebastian A1 - Rother, Karl-Heinz A1 - Schröter, Kai T1 - Das Hochwasser im Juni 2013 BT - Bewährungsprobe für das Hochwasserrisikomanagement in Deutschland T3 - Schriftenreihe des DKKV ; 53 Y1 - 2015 SN - 978-3-933181-62-6 PB - Deutsches Komitee Katastrophenvorsorge CY - Bonn ER - TY - JOUR A1 - Thieken, Annegret A1 - Kienzler, Sarah A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Mühr, Bernhard A1 - Müller, Meike A1 - Otto, Antje A1 - Petrow, Theresia A1 - Pisi, Sebastian A1 - Schröter, Kai T1 - Review of the flood risk management system in Germany after the major flood in 2013 JF - Ecology and society : E&S ; a journal of integrative science for resilience and sustainability N2 - Widespread flooding in June 2013 caused damage costs of €6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of €11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all stakeholders. KW - August 2002 flood KW - Central Europe KW - Floods Directive KW - governance KW - June 2013 flood KW - risk management cycle Y1 - 2016 U6 - https://doi.org/10.5751/ES-08547-210251 SN - 1708-3087 SN - 1195-5449 VL - 21 IS - 2 PB - Resilience Alliance CY - Wolfville, NS ER - TY - JOUR A1 - Thieken, Annegret A1 - Otto, Antje A1 - Pisi, Sebastian A1 - Petrow, Theresia A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Schröter, Kai A1 - Kienzler, Sarah A1 - Müller, Meike T1 - Schlussfolgerungen und Empfehlungen JF - Das Hochwasser im Juni 2013 : Bewährungsprobe für das Hochwasserrisikomanagement in Deutschland Y1 - 2015 SN - 978-3-933181-62-6 SP - 184 EP - 196 PB - Deutsches Komitee Katastrophenvorsorge CY - Bonn ER - TY - JOUR A1 - Thieken, Annegret A1 - Kienzler, Sarah A1 - Kreibich, Heidi A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Muehr, Bernhard A1 - Mueller, Meike A1 - Otto, Antje A1 - Petrow, Theresia A1 - Pisi, Sebastian A1 - Schroeter, Kai T1 - Review of the flood risk management system in Germany after the major flood in 2013 JF - Ecology and society : a journal of integrative science for resilience and sustainability N2 - Widespread flooding in June 2013 caused damage costs of (sic)6 to 8 billion in Germany, and awoke many memories of the floods in August 2002, which resulted in total damage of (sic)11.6 billion and hence was the most expensive natural hazard event in Germany up to now. The event of 2002 does, however, also mark a reorientation toward an integrated flood risk management system in Germany. Therefore, the flood of 2013 offered the opportunity to review how the measures that politics, administration, and civil society have implemented since 2002 helped to cope with the flood and what still needs to be done to achieve effective and more integrated flood risk management. The review highlights considerable improvements on many levels, in particular (1) an increased consideration of flood hazards in spatial planning and urban development, (2) comprehensive property-level mitigation and preparedness measures, (3) more effective flood warnings and improved coordination of disaster response, and (4) a more targeted maintenance of flood defense systems. In 2013, this led to more effective flood management and to a reduction of damage. Nevertheless, important aspects remain unclear and need to be clarified. This particularly holds for balanced and coordinated strategies for reducing and overcoming the impacts of flooding in large catchments, cross-border and interdisciplinary cooperation, the role of the general public in the different phases of flood risk management, as well as a transparent risk transfer system. Recurring flood events reveal that flood risk management is a continuous task. Hence, risk drivers, such as climate change, land-use changes, economic developments, or demographic change and the resultant risks must be investigated at regular intervals, and risk reduction strategies and processes must be reassessed as well as adapted and implemented in a dialogue with all stakeholders. KW - August 2002 flood KW - Central Europe KW - Floods Directive KW - governance KW - June 2013 flood KW - risk management cycle Y1 - 2016 U6 - https://doi.org/10.5751/ES-08547-210251 SN - 1708-3087 VL - 21 SP - 8612 EP - 8614 PB - Resilience Alliance CY - Wolfville ER - TY - JOUR A1 - Arnold, Rafael A1 - Balla, Zsolt A1 - Cohen, Susan A1 - Conway-Jones, Ann A1 - Dallapiazza, Michael A1 - Denz, Rebekka A1 - Freud-Kandel, Miri A1 - Griffiths, Toni A1 - Grözinger, Elvira A1 - Himmelmann, Werner A1 - Hiscott, William A1 - Hoffmann, Daniel A1 - Horch, Hans-Otto A1 - Kellner-Rauch, Heike A1 - Lehnguth, Cornelius A1 - Martini, Annett A1 - Pella, Sebastian A1 - Rosner, Anna A1 - Szulc, Michał A1 - Wurbs, Janina A1 - Wynn, Natalie ED - Denz, Rebekka ED - Jurewicz, Grażyna ED - Salzer, Dorothea M. T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = Einblicke in die ‚British Jewish Studies‘ T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = Insight into ‘British Jewish Studies’ N2 - PaRDeS. Zeitschrift der Vereinigung für Jüdische Studien e. V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung. N2 - PaRDeS. Journal of the Association of Jewish Studies e. V. The journal aims at documenting the fruitful and multifarious culture of Judaism as well as its relations to its environment within diverse areas of research. In addition, the journal is meant to promote Jewish Studies within academic discourse and discuss its historic and social responsibility. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 18 Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-59255 SN - 978-3-86956-177-6 SN - 1614-6492 SN - 1862-7684 IS - 18 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Malinova, Irina A1 - Mahlow, Sebastian A1 - Alseekh, Saleh A1 - Orawetz, Tom A1 - Fernie, Alisdair A1 - Baumann, Otto A1 - Steup, Martin A1 - Fettke, Jörg T1 - Double knockout mutants of arabidopsis grown under normal conditions reveal that the plastidial phosphorylase isozyme participates in transitory starch metabolism JF - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants N2 - In leaves of two starch-related single-knockout lines lacking either the cytosolic transglucosidase (also designated as disproportionating enzyme 2, DPE2) or the maltose transporter (MEX1), the activity of the plastidial phosphorylase isozyme (PHS1) is increased. In both mutants, metabolism of starch-derived maltose is impaired but inhibition is effective at different subcellular sites. Two constitutive double knockout mutants were generated (designated as dpe2-1 x phs1a and mex1 x phs1b) both lacking functional PHS1. They reveal that in normally grown plants, the plastidial phosphorylase isozyme participates in transitory starch degradation and that the central carbon metabolism is closely integrated into the entire cell biology. All plants were grown either under continuous illumination or in a light-dark regime. Both double mutants were compromised in growth and, compared with the single knockout plants, possess less average leaf starch when grown in a light-dark regime. Starch and chlorophyll contents decline with leaf age. As revealed by transmission electron microscopy, mesophyll cells degrade chloroplasts, but degradation is not observed in plants grown under continuous illumination. The two double mutants possess similar but not identical phenotypes. When grown in a light-dark regime, mesophyll chloroplasts of dpe2-1 x phs1a contain a single starch granule but under continuous illumination more granules per chloroplast are formed. The other double mutant synthesizes more granules under either growth condition. In continuous light, growth of both double mutants is similar to that of the parental single knockout lines. Metabolite profiles and oligoglucan patterns differ largely in the two double mutants. Y1 - 2014 U6 - https://doi.org/10.1104/pp.113.227843 SN - 0032-0889 SN - 1532-2548 VL - 164 IS - 2 SP - 907 EP - 921 PB - American Society of Plant Physiologists CY - Rockville ER -