TY  - JOUR
A1  - Altmann, Thomas
A1  - Brandt, Stephan Peter
A1  - Kloska, Sebastian
A1  - Kehr, Julia
T1  - Using array hybridization to monitore gene expression at the single cell level
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Daub, Carsten O.
A1  - Steuer, Ralf
A1  - Selbig, Joachim
A1  - Kloska, Sebastian
T1  - Estimating mutual information using B-spline functions : an improved similarity measure for analysing gene expression data
N2  - Background: The information theoretic concept of mutual information provides a general framework to evaluate dependencies between variables. In the context of the clustering of genes with similar patterns of expression it has been suggested as a general quantity of similarity to extend commonly used linear measures. Since mutual information is defined in terms of discrete variables, its application to continuous data requires the use of binning procedures, which can lead to significant numerical errors for datasets of small or moderate size. Results: In this work, we propose a method for the numerical estimation of mutual information from continuous data. We investigate the characteristic properties arising from the application of our algorithm and show that our approach outperforms commonly used algorithms: The significance, as a measure of the power of distinction from random correlation, is significantly increased. This concept is subsequently illustrated on two large-scale gene expression datasets and the results are compared to those obtained using other similarity measures. A C++ source code of our algorithm is available for non- commercial use from kloska@scienion.de upon request. Conclusion: The utilisation of mutual information as similarity measure enables the detection of non-linear correlations in gene expression datasets. Frequently applied linear correlation measures, which are often used on an ad-hoc basis without further justification, are thereby extended
Y1  - 2004
SN  - 1471-2105
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Udvardi, M. K.
A1  - Essigmann, B.
A1  - Colebatch, G.
A1  - Kloska, Sebastian
A1  - Smith, P.
A1  - Trevaskis, B.
T1  - Lotus japonicus functional genomics : cDNA microarray analysis uncovers novel nodulins
Y1  - 2002
SN  - 0-85199-591-8
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Colebatch, G.
A1  - Kloska, Sebastian
A1  - Trevaskis, B.
A1  - Freund, S.
A1  - Udvardi, M. K.
T1  - Novel aspects of symbiotic nitrogen fixation uncovered by transcript profiling with cDNA arrays
Y1  - 2002
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Fiehn, Oliver
A1  - Kloska, Sebastian
T1  - Integrated studies on plant biology using multiparallel techniques
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Thimm, O.
A1  - Essigmann, B.
A1  - Kloska, Sebastian
A1  - Buckhout, Thomas J.
T1  - Response of arabidopsis to iron deficiency stress as revealed by microarray analysis
Y1  - 2001
ER  -