TY - JOUR A1 - Weber, Michael A1 - Scholz, Denis A1 - Schröder-Ritzrau, Andrea A1 - Deininger, Michael A1 - Spötl, Christoph A1 - Lugli, Federico A1 - Mertz-Kraus, Regina A1 - Jochum, Klaus Peter A1 - Fohlmeister, Jens Bernd A1 - Stumpf, Cintia F. A1 - Riechelmann, Dana F. C. T1 - Evidence of warm and humid interstadials in central Europe during early MISSUE 3 revealed by a multi-proxy speleothem record JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Marine Isotope Stage 3 (MIS 3, 57-27 ka) was characterised by numerous rapid climate oscillations (i.e., Dansgaard-Oeschger (D/O-) events), which are reflected in various climate archives. So far, MIS 3 speleothem records from central Europe have mainly been restricted to caves located beneath temperate Alpine glaciers or close to the Atlantic Ocean. Thus, MIS 3 seemed to be too cold and dry to enable speleothem growth north of the Alps in central Europe. Here we present a new speleothem record from Bunker Cave, Germany, which shows two distinct growth phases from 52.0 (+0.8, -0.5) to 50.9 (+0.6, -1.3) ka and 473 (+1.0, -0.6) to 42.8 (+/- 0.9) ka, rejecting this hypothesis. These two growth phases potentially correspond to the two warmest and most humid phases in central Europe during MIS 3, which is confirmed by pollen data from the nearby Eifel. The hiatus separating the two phases is associated with Heinrich stadial 5 (HS 5), although the growth stop precedes the onset of HS 5. The first growth phase is characterised by a fast growth rate, and Mg concentrations and Sr isotope data suggest high infiltration and the presence of soil cover above the cave. The second growth phase was characterised by drier, but still favourable conditions for speleothem growth. During this phase, the delta C-13 values show a significant decrease associated with D/O-event 12. The timing of this shift is in agreement with other MIS 3 speleothem data from Europe and Greenland ice core data. (C) 2018 Elsevier Ltd. All rights reserved. KW - Speleothems KW - Pleistocene KW - Palaeoclimatology KW - Europe KW - Dansgaard-Oeschger event KW - Marine isotope stage 3 KW - Bunker cave KW - Multi-proxy approach KW - U-Th series Y1 - 2018 U6 - https://doi.org/10.1016/j.quascirev.2018.09.045 SN - 0277-3791 VL - 200 SP - 276 EP - 286 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Rudner, Michael A1 - Schröder-Esselbach, Boris A1 - Biedermann, Robert A1 - Kleyer, Michael T1 - Habitatmodellierung in GIMOLUS : e-Learning Module zur Verwendung der logistischen Regression zur Analyse der Art-Umwelt-Beziehungen Y1 - 2004 UR - http://brandenburg.geoecology.uni-potsdam.de/users/schroeder/download/publications/ rudner_etal_ufzbericht9_2004.pdf ER - TY - JOUR A1 - Kleyer, Michael A1 - Schröder-Esselbach, Boris A1 - Biedermann, Robert A1 - Rudner, Michael A1 - Fritzsch, K. A1 - Kühner, A. A1 - Poschlod, P. A1 - Kahmen, S. A1 - Tackenberg, O. A1 - Talmon, E. A1 - Poethke, H.-J. A1 - Obermaier, E. A1 - Hein, S. A1 - Hinsch, M. A1 - Henle, K. A1 - Settele, Josef A1 - Binzenhöfer, Birgit A1 - Pfeifer, A. A1 - Kögl, H. T1 - Freie Beweidung mit geringer Besatzdichte und Fräsen als alternative Verfahren zur Pflege von Magerrasen Y1 - 2004 SN - 0341-7026 ER - TY - JOUR A1 - Schröder-Esselbach, Boris A1 - Rudner, Michael A1 - Biedermann, Robert A1 - Kleyer, Michael T1 - Ökologische & sozio-ökonomische Bewertung von Managementsystemen für die Offenhaltung von Landschaften - ein integriertes Landschaftsmodell Y1 - 2004 UR - http://brandenburg.geoecology.uni-potsdam.de/users/schroeder/download/publications/ schroeder_etal_ufzbericht9_2004.pdf ER - TY - JOUR A1 - Rudner, Michael A1 - Schröder-Esselbach, Boris A1 - Biedermann, Robert A1 - Kleyer, Michael T1 - Habitatmodellierung in der Landschaftsökologie N2 - Das Teilprojekt Landschafts- und Autökologie (LÖK) hat den Schwerpunkt auf die Erarbeitung einer e- Learning-Einheit zur Habitatmodellierung im allgemeinen und dem Verfahren der logistischen Regression im speziellen gelegt. In den sechs Lernmodulen der Lerneinheit werden alle für eine erfolgreiche Modellierung der Habitateignung erforderlichen Arbeitsschritte sequentiell behandelt. Die wesentlichen Schritte werden mit interaktiven Aufgaben vertieft, in welchen an entscheidenden Stellen WebGIS eingesetzt wird. Der räumliche Bezug wird in der Regel über WebGIS- Anwendungen zu einer virtuellen Landschaft hergestellt, die in das GIMOLUS-System integriert ist. Die erforderlichen Datensätze für die Analyse von Art-Habitat- Beziehungen werden bereitgestellt oder können interaktiv aus der virtuellen Landschaft erzeugt werden. Y1 - 2003 SN - 3-87907-417-8 ER - TY - JOUR A1 - Mitzner, Rolf A1 - Rehanek, Jens A1 - Kern, Jan A1 - Gul, Sheraz A1 - Hattne, Johan A1 - Taguchi, Taketo A1 - Alonso-Mori, Roberto A1 - Tran, Rosalie A1 - Weniger, Christian A1 - Schröder, Henning A1 - Quevedo, Wilson A1 - Laksmono, Hartawan A1 - Sierra, Raymond G. A1 - Han, Guangye A1 - Lassalle-Kaiser, Benedikt A1 - Koroidov, Sergey A1 - Kubicek, Katharina A1 - Schreck, Simon A1 - Kunnus, Kristjan A1 - Brzhezinskaya, Maria A1 - Firsov, Alexander A1 - Minitti, Michael P. A1 - Turner, Joshua J. A1 - Möller, Stefan A1 - Sauter, Nicholas K. A1 - Bogan, Michael J. A1 - Nordlund, Dennis A1 - Schlotter, William F. A1 - Messinger, Johannes A1 - Borovik, Andrew S. A1 - Techert, Simone A1 - de Groot, Frank M. F. A1 - Föhlisch, Alexander A1 - Erko, Alexei A1 - Bergmann, Uwe A1 - Yachandra, Vittal K. A1 - Wernet, Philippe A1 - Yano, Junko T1 - L-edge x-ray absorption spectroscopy of dilute systems relevant to metalloproteins using an X-ray free-electron laser JF - The journal of physical chemistry letters N2 - L-edge spectroscopy of 3d transition metals provides important electronic structure information and has been used in many fields. However, the use of this method for studying dilute aqueous systems, such as metalloenzymes, has not been prevalent because of severe radiation damage and the lack of suitable detection systems. Here we present spectra from a dilute Mn aqueous solution using a high-transmission zone-plate spectrometer at the Linac Coherent Light Source (LCLS). The spectrometer has been optimized for discriminating the Mn L-edge signal from the overwhelming 0 K-edge background that arises from water and protein itself, and the ultrashort LCLS X-ray pulses can outrun X-ray induced damage. We show that the deviations of the partial-fluorescence yield-detected spectra from the true absorption can be well modeled using the state-dependence of the fluorescence yield, and discuss implications for the application of our concept to biological samples. Y1 - 2013 U6 - https://doi.org/10.1021/jz401837f SN - 1948-7185 VL - 4 IS - 21 SP - 3641 EP - 3647 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Aichert, Ingrid A1 - Staiger, Anja A1 - Schulte-Mäter, Anne A1 - Becker-Redding, Ulrike A1 - Stahn, Corinna A1 - Peschke, Claudia A1 - Heide, Judith A1 - Ott, Susan A1 - Herrmann, Heike A1 - Völsch, Juliane A1 - Mayer, Jörg A1 - Rohnke, Lucie A1 - Frank, Ulrike A1 - Stadie, Nicole A1 - Jentsch, Nadine A1 - Blech, Anke A1 - Kurtenbach, Stephanie A1 - Thieke, Johanna A1 - Schröder, Astrid A1 - Stahn, Corinna A1 - Hörnig, Robin A1 - Burchert, Frank A1 - De Bleser, Ria A1 - Heister, Julian A1 - Bartels, Luise A1 - Würzner, Kay-Michael A1 - Böhme, Romy A1 - Burmester, Juliane A1 - Krajewski, Melanie A1 - Nager, Wido A1 - Jungehülsing, Gerhard Jan A1 - Wartenburger, Isabell A1 - Jöbges, Michael A1 - Schwilling, Eleonore A1 - Lidzba, Karen A1 - Winkler, Susanne A1 - Konietzko, Andreas A1 - Krägeloh-Mann, Ingeborg A1 - Rilling, Eva A1 - Wilken, Rainer A1 - Wismann, Kathrin A1 - Glandorf, Birte A1 - Hoffmann, Hannah A1 - Hinnenkamp, Christiane A1 - Rohlmann, Insa A1 - Ludewigt, Jacqueline A1 - Bittner, Christian A1 - Orlov, Tatjana A1 - Claus, Katrin A1 - Ehemann, Christine A1 - Winnecken, Andreas A1 - Hummel, Katja A1 - Breitenstein, Sarah ED - Wahl, Michael ED - Stahn, Corinna ED - Hanne, Sandra ED - Fritzsche, Tom T1 - Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen N2 - Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universität Potsdam statt. Der vorliegende Tagungsband enthält die drei Hauptvorträge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen“. Darüber hinaus enthält der Band die Beiträge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpräsentationen. N2 - The 3rd Herbsttreffen Patholinguistik was held on November 21st, 2009 at the University of Potsdam. These proceedings contain the three main lectures of the central topic „From programming to articulation: Apraxia of speech of children and adults “. Additionally this volume contains the contributions of Spektrum Patholinguistik, as well as the abstracts of the poster presentations. T3 - Spektrum Patholinguistik - 3 KW - Patholinguistik KW - Sprechapraxie KW - Sprachtherapie KW - patholinguistics KW - apraxia of speech KW - speech and language therapy Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45470 SN - 978-3-86956-079-3 SN - 1869-3822 SN - 1866-9433 IS - 3 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Liebchen, Uwe A1 - Weinelt, Ferdinand A1 - Scharf, Christina A1 - Schröder, Ines A1 - Paal, Michael A1 - Zoller, Michael A1 - Kloft, Charlotte A1 - Jung, Jette A1 - Michelet, Robin T1 - Combination of pharmacokinetic and pathogen susceptibility information to optimize meropenem treatment of Gram-negative infections in critically iII patients JF - Antimicrobial Agents and Chemotherapy N2 - Meropenem is one of the most frequently used antibiotics to treat life-threatening infections in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the treatment of Gram-negative infections based on intensive care unit (ICU)-specific resistance data. Antimicrobial susceptibility testing of Gram-negative bacteria obtained from critically ill patients was carried out from 2016 to 2020 at a tertiary care hospital. Based on the observed MIC distribution, stochastic simulations (n = 1,000) of an evaluated pharmacokinetic meropenem model, and a defined pharmacokinetic/pharmacodynamic target (100%T->4xMIC while minimum concentrations were <44.5 mg/L), dosing recommendations for patients with varying renal function were derived. Pathogen-specific MIC distributions were used to calculate the cumulative fraction of response (CFR), and the overall MIC distribution was used to calculate the local pathogen-independent mean fraction of response (LPIFR) for the investigated dosing regimens. A CFR/LPIFR of >90% was considered adequate. The observed MIC distribution significantly differed from the EUCAST database. Based on the 6,520 MIC values included, a three-level dosing algorithm was developed. If the pathogen causing the infection is unknown (level 1), known (level 2), known to be neither Pseudomonas aeruginosa nor Acinetobacrer baumannii, or classified as susceptible (level 3), a continuous infusion of 1.5 g daily reached sufficient target attainment independent of renal function. In all other cases, dosing needs to be adjusted based on renal function. ICU-specific susceptibility data should be assessed regularly and integrated into dosing decisions. The presented workflow may serve as a blueprint for other antimicrobial settings. KW - meropenem KW - critically ill KW - antimicrobial susceptibility testing KW - Gram negative KW - dosing algorithm Y1 - 2022 U6 - https://doi.org/10.1128/aac.01831-21 SN - 0066-4804 SN - 1098-6596 VL - 66 IS - 2 PB - American Society for Microbiology CY - Washington ER - TY - JOUR A1 - Blankertz, Benjamin A1 - Müller, Klaus-Robert A1 - Curio, Gabriel A1 - Vaughan, Theresa M. A1 - Schalk, Gerwin A1 - Wolpaw, Jonathan R. A1 - Schlogl, Alois A1 - Neuper, Christa A1 - Pfurtscheller, Gert A1 - Hinterberger, Thilo A1 - Schroder, Michael A1 - Birbaumer, Niels T1 - The BCI competition 2003 : Progress and perspectives in detection and discrimination of EEG single trials N2 - Interest in developing a new method of man-to-machine communication-a brain-computer interface (BCI)-has grown steadily over the past few decades. BCIs create a new communication channel between the brain and an output device by bypassing conventional motor output pathways of nerves and muscles. These systems use signals recorded from the scalp, the surface of the cortex, or from inside the brain to enable users to control a variety of applications including simple word-processing software and orthotics. BCI technology could therefore provide a new communication and control option for individuals who cannot otherwise express their wishes to the outside world. Signal processing and classification methods are essential tools in the development of improved BCI technology. We organized the BCI Competition 2003 to evaluate the current state of the art of these tools. Four laboratories well versed in EEG-based BCI research provided six data sets in a documented format. We made these data sets (i.e., labeled training sets and unlabeled test sets) and their descriptions available on the Internet. The goal in the competition was to maximize the performance measure for the test labels. Researchers worldwide tested their algorithms and competed for the best classification results. This paper describes the six data sets and the results and function of the most successful algorithms Y1 - 2004 SN - 0018-9294 ER - TY - JOUR A1 - Rudner, Michael A1 - Schröder-Esselbach, Boris A1 - Biedermann, Robert A1 - Müller, Mark T1 - Habitat modelling in GIMOLUS - webGIS-based e-learning modules using logistic regression to assess species- habitat relationships Y1 - 2003 UR - http://brandenburg.geoecology.uni-potsdam.de/users/schroeder/download/publications/ rudner_schroeder_biedermann_mueller_agit2003.pdf ER -