TY - JOUR A1 - Brietzke, Thomas Martin A1 - Dietz, Thomas A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Bois, Juliana A1 - Kelm, Harald A1 - Reh, Manuel A1 - Schmitz, Markus A1 - Koerzdoerfer, Thomas A1 - Leimkühler, Silke A1 - Wollenberger, Ulla A1 - Krueger, Hans-Joerg A1 - Holdt, Hans-Jürgen T1 - The 1,6,7,12-Tetraazaperylene Bridging Ligand as an Electron Reservoir and Its Disulfonato Derivative as Redox Mediator in an Enzyme-Electrode Process JF - Chemistry - a European journal N2 - The homodinuclear ruthenium(II) complex [{Ru(l-N4Me2)}(2)(-tape)](PF6)(4) {[1](PF6)(4)} (l-N4Me2=N,N-dimethyl-2,11-diaza[3.3](2,6)-pyridinophane, tape=1,6,7,12-tetraazaperylene) can store one or two electrons in the energetically low-lying * orbital of the bridging ligand tape. The corresponding singly and doubly reduced complexes [{Ru(l-N4Me2)}(2)(-tape(.-))](PF6)(3) {[2](PF6)(3)} and [{Ru(l-N4Me2)}(2)(-tape(2-))](PF6)(2) {[3](PF6)(2)}, respectively, were electrochemically generated, successfully isolated and fully characterized by single-crystal X-ray crystallography, spectroscopic methods and magnetic susceptibility measurements. The singly reduced complex [2](PF6)(3) contains the -radical tape(.-) and the doubly reduced [3](PF6)(2) the diamagnetic dianion tape(2-) as bridging ligand, respectively. Nucleophilic aromatic substitution at the bridging tape in [1](4+) by two sulfite units gave the complex [{Ru(l-N4Me2)}(2){-tape-(SO3)(2)}](2+) ([4](2+)). Complex dication [4](2+) was exploited as a redox mediator between an anaerobic homogenous reaction solution of an enzyme system (sulfite/sulfite oxidase) and the electrode via participation of the low-energy *-orbital of the disulfonato-substituted bridging ligand tape-(SO3)(2)(2-) (E-red1=-0.1V versus Ag/AgCl/1m KCl in water). KW - electrochemistry KW - enzyme catalysis KW - N-ligands KW - redox-active ligands KW - ruthenium Y1 - 2017 U6 - https://doi.org/10.1002/chem.201703639 SN - 0947-6539 SN - 1521-3765 VL - 23 SP - 15583 EP - 15587 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schmitz, Claudia A1 - Fuchs, Thomas A1 - van Nimwegen, Olaf A1 - Oestmann, Anne A1 - Costello, Vivien A1 - von Schnurbein, Vladimir A1 - Probst, Thomas W. A1 - Maier, Gregor A1 - Jörgensen, Bent A1 - Krug, Raphael Matthias A1 - Lüdke, Christine A1 - Schmitt, Bernhard A1 - Franz, Matthias A1 - Winter, Martin A1 - Brockfeld, Susanne T1 - Militär und Gesellschaft in der Frühen Neuzeit N2 - Inhalt: Beiträge: Claudia Schmitz: Gewaltanwendung und -wahrnehmung in der frühen Kontaktsituation zwischen Indianern und Europäern, Peru 1532/33 Thomas Fuchs: Von der Büchersammlung zur Bibliothek. Regimentsbibliotheken des 18. und 19. Jahrhunderts in Hannover Olaf von Nimwegen: The Dutch Army and the Military Revolutions (1588-1688) Anne Oestmann: Billeting in England during the Reign of Charles I, 1625-1649, The Case of Tickhill/Yorkshire Projekte: Vivien Costello: Ein biographisches Lexikon hugenottischer Offiziere in europäischen Armeen 1660-1780 Vladimier von Schnurbein: Die Rolle des Johanniter-Ordens bei der kontinentalen Türkenabwehr im 16. Jahrhundert Berichte: Thomas W. Probst: Tagung des Arbeitskreises Militärgeschichte (AKM) 2005, "Kriegsgreuel", 3.-5. November 2005 in Mainz Gregor Maier: Krieg, Militär und Migration in der Frühen Neuzeit. 6. Jahrestagung des Arbeitskreises "Militär und Gesellschaft in der Frühen Neuzeit" gemeinsam mit dem Tübinger Sonderforschungsbereich 437 Bent Jörgensen, Raphael Matthias Krug, Christine Lüdke: Friedensschlüsse - Medien im Umfeld der Konfliktbewältigung im Mittelalter und der Frühen Neuzeit Horst Bernhard Schmitt: Militär und Gesellschaft in Herrschaftswechseln Rezensionen Matthias Franz: Jörg Rathjen: Soldaten im Dorf. Ländliche Gesellschaft und Kriege in den Herzogtümern Schleswig und Holstein Martin Winter: Peter Engerisser: Von Kronach nach Nördlingen. Der Dreißigjährige Krieg in Franken, Schwaben und der Oberpfalz 1631-1635 Ankündigungen Susanne Brockfeld: Staatsbankrott! Bankrotter Staat? Finanzreform und gesellschaftlicher Wandel in Preußen nach 1806. Eine Ausstellung des Geheimen Staatsarchivs Preußischer Kulturbesitz 12. Mai bis 28. Juni 2006 in Berlin Ich dien' nicht! Wehrdienstverweigerung in der Geschichte, Reinbek bei Hamburg, 20. bis 22. Oktober 2006 T3 - Militär und Gesellschaft in der frühen Neuzeit - 10, Heft 1 Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-12626 SN - 1617-9722 SN - 1861-910X VL - 10 IS - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - de Vera, Jean-Pierre Paul A1 - Böttger, Ute A1 - de la Torre Nötzel, Rosa A1 - Sanchez, Francisco J. A1 - Grunow, Dana A1 - Schmitz, Nicole A1 - Lange, Caroline A1 - Hübers, Heinz-Wilhelm A1 - Billi, Daniela A1 - Baque, Mickael A1 - Rettberg, Petra A1 - Rabbow, Elke A1 - Reitz, Günther A1 - Berger, Thomas A1 - Möller, Ralf A1 - Bohmeier, Maria A1 - Horneck, Gerda A1 - Westall, Frances A1 - Jänchen, Jochen A1 - Fritz, Jörg A1 - Meyer, Cornelia A1 - Onofri, Silvano A1 - Selbmann, Laura A1 - Zucconi, Laura A1 - Kozyrovska, Natalia A1 - Leya, Thomas A1 - Foing, Bernard A1 - Demets, Rene A1 - Cockell, Charles S. A1 - Bryce, Casey A1 - Wagner, Dirk A1 - Serrano, Paloma A1 - Edwards, Howell G. M. A1 - Joshi, Jasmin Radha A1 - Huwe, Björn A1 - Ehrenfreund, Pascale A1 - Elsaesser, Andreas A1 - Ott, Sieglinde A1 - Meessen, Joachim A1 - Feyh, Nina A1 - Szewzyk, Ulrich A1 - Jaumann, Ralf A1 - Spohn, Tilman T1 - Supporting Mars exploration BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology JF - Planetary and space science N2 - The Low Earth Orbit (LEO) experiment Biology and Mars Experiment (BIOMEX) is an interdisciplinary and international space research project selected by ESA. The experiment will be accommodated on the space exposure facility EXPOSE-R2 on the International Space Station (ISS) and is foreseen to be launched in 2013. The prime objective of BIOMEX is to measure to what extent biomolecules, such as pigments and cellular components, are resistant to and able to maintain their stability under space and Mars-like conditions. The results of BIOMEX will be relevant for space proven biosignature definition and for building a biosignature data base (e.g. the proposed creation of an international Raman library). The library will be highly relevant for future space missions such as the search for life on Mars. The secondary scientific objective is to analyze to what extent terrestrial extremophiles are able to survive in space and to determine which interactions between biological samples and selected minerals (including terrestrial, Moon- and Mars analogs) can be observed under space and Mars-like conditions. In this context, the Moon will be an additional platform for performing similar experiments with negligible magnetic shielding and higher solar and galactic irradiation compared to LEO. Using the Moon as an additional astrobiological exposure platform to complement ongoing astrobiological LEO investigations could thus enhance the chances of detecting organic traces of life on Mars. We present a lunar lander mission with two related objectives: a lunar lander equipped with Raman and PanCam instruments which can analyze the lunar surface and survey an astrobiological exposure platform. This dual use of testing mission technology together with geo- and astrobiological analyses will significantly increase the science return, and support the human preparation objectives. It will provide knowledge about the Moon's surface itself and, in addition, monitor the stability of life-markers, such as cells, cell components and pigments, in an extraterrestrial environment with much closer radiation properties to the surface of Mars. The combination of a Raman data base of these data together with data from LEO and space simulation experiments, will lead to further progress on the analysis and interpretation of data that we will obtain from future Moon and Mars exploration missions. KW - Moon KW - Mars KW - Low Earth Orbit KW - Astrobiology KW - Instrumentation KW - Spectroscopy KW - Biosignature Y1 - 2012 U6 - https://doi.org/10.1016/j.pss.2012.06.010 SN - 0032-0633 VL - 74 IS - 1 SP - 103 EP - 110 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Endesfelder, Stefanie A1 - Weichelt, Ulrike A1 - Strauß, Evelyn A1 - Schlör, Anja A1 - Sifringer, Marco A1 - Scheuer, Till A1 - Bührer, Christoph A1 - Schmitz, Thomas T1 - Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury JF - International journal of molecular sciences N2 - Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term “oxygen radical disease of prematurity”. Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28–32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NFκB), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties. KW - anti-oxidative response KW - caffeine KW - hyperoxia KW - oxidative stress KW - preterm infants KW - developing brain Y1 - 2017 U6 - https://doi.org/10.3390/ijms18010187 SN - 1422-0067 SN - 1661-6596 VL - 18 PB - Molecular Diversity Preservation International CY - Basel ER - TY - GEN A1 - Endesfelder, Stefanie A1 - Weichelt, Ulrike A1 - Strauß, Evelyn A1 - Schlör, Anja A1 - Sifringer, Marco A1 - Scheuer, Till A1 - Bührer, Christoph A1 - Schmitz, Thomas T1 - Neuroprotection by caffeine in hyperoxia-induced neonatal brain injury T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease of prematurity". Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28-32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NF kappa B), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1097 KW - anti-oxidative response KW - caffeine KW - hyperoxia KW - oxidative stress KW - preterm infants KW - developing brain Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475040 SN - 1866-8372 IS - 1097 ER - TY - BOOK A1 - Bauer, Hartmut A1 - Budäus, Dietrich A1 - Grüb, Birgit A1 - Schmitz, Heribert A1 - Reichard, Christoph A1 - Mestwerdt, Thomas A1 - Schenke, Ralf P. A1 - Schaedel, Volker A1 - Paffhausen, Peter ED - Bauer, Hartmut ED - Büchner, Christiane ED - Brosius-Gersdorf, Frauke T1 - Verwaltungskooperation : Public Private Partnerships und Public Public Partnerships N2 - Public Private Partnerships (PPP) sind aktueller denn je: Die Aufgaben der Kommunen werden immer komplexer und lassen sich oft nur meistern, wenn die Last auf mehrere Schultern verteilt wird. Für die Kommunen bieten PPPs die Chance zu einer schnelleren, bürgernäheren und bedarfsgerechteren Aufgabenerfüllung, zur Konzentration auf kommunale Kernkompetenzen, zur Nutzung privaten Know-hows sowie zu Kosteneinsparungen und Effizienzgewinnen. Für die privaten Partner sind PPPs eine Möglichkeit zur Erschließung neuer Märkte und Generierung lukrativer Aufträge. Gleichzeitig bringen die Planung, die Finanzierung, der Betrieb und die Beendigung Öffentlich Privater Partnerschaften jedoch komplexe rechtliche und praktische Probleme mit sich. Vor diesem Hintergrund widmete sich die 14. Jahrestagung des Kommunalwissenschaftlichen Institutes (KWI) der Universität Potsdam im April 2008 den rechtlichen Rahmenbedingungen und den praktischen Problemen im alltäglichen Umgang mit PPPs. Sie beleuchtete die verschiedenen Stationen des Lebenslaufs von PPPs und gab Antworten auf wichtige Fragestellungen bei der Implementierung und Umsetzung von PPP-Projekten. Behandelt wurden unter anderem Themen wie die Novellierung des Vertragsrechts im Verwaltungsverfahrensgesetz, Direktiven des Vergaberechts, Möglichkeiten der Finanzierung durch EU-Fördermittel sowie institutionelle Alternativen (insbes. Public Public Partnerships) und Lösungswege beim Scheitern von PPPs. T3 - KWI-Schriften - 1 Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-27583 SN - 978-3-940793-68-3 ER -