TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - JOUR
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
JF  - Kidney international : official journal of the International Society of Nephrology
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - https://doi.org/10.1016/j.kint.2020.09.030
SN  - 0085-2538
SN  - 1523-1755
VL  - 99
IS  - 4
SP  - 926
EP  - 939
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - CHAP
A1  - Kurbel, Karl
A1  - Nowak, Dawid
A1  - Azodi, Amir
A1  - Jaeger, David
A1  - Meinel, Christoph
A1  - Cheng, Feng
A1  - Sapegin, Andrey
A1  - Gawron, Marian
A1  - Morelli, Frank
A1  - Stahl, Lukas
A1  - Kerl, Stefan
A1  - Janz, Mariska
A1  - Hadaya, Abdulmasih
A1  - Ivanov, Ivaylo
A1  - Wiese, Lena
A1  - Neves, Mariana
A1  - Schapranow, Matthieu-Patrick
A1  - Fähnrich, Cindy
A1  - Feinbube, Frank
A1  - Eberhardt, Felix
A1  - Hagen, Wieland
A1  - Plauth, Max
A1  - Herscheid, Lena
A1  - Polze, Andreas
A1  - Barkowsky, Matthias
A1  - Dinger, Henriette
A1  - Faber, Lukas
A1  - Montenegro, Felix
A1  - Czachórski, Tadeusz
A1  - Nycz, Monika
A1  - Nycz, Tomasz
A1  - Baader, Galina
A1  - Besner, Veronika
A1  - Hecht, Sonja
A1  - Schermann, Michael
A1  - Krcmar, Helmut
A1  - Wiradarma, Timur Pratama
A1  - Hentschel, Christian
A1  - Sack, Harald
A1  - Abramowicz, Witold
A1  - Sokolowska, Wioletta
A1  - Hossa, Tymoteusz
A1  - Opalka, Jakub
A1  - Fabisz, Karol
A1  - Kubaczyk, Mateusz
A1  - Cmil, Milena
A1  - Meng, Tianhui
A1  - Dadashnia, Sharam
A1  - Niesen, Tim
A1  - Fettke, Peter
A1  - Loos, Peter
A1  - Perscheid, Cindy
A1  - Schwarz, Christian
A1  - Schmidt, Christopher
A1  - Scholz, Matthias
A1  - Bock, Nikolai
A1  - Piller, Gunther
A1  - Böhm, Klaus
A1  - Norkus, Oliver
A1  - Clark, Brian
A1  - Friedrich, Björn
A1  - Izadpanah, Babak
A1  - Merkel, Florian
A1  - Schweer, Ilias
A1  - Zimak, Alexander
A1  - Sauer, Jürgen
A1  - Fabian, Benjamin
A1  - Tilch, Georg
A1  - Müller, David
A1  - Plöger, Sabrina
A1  - Friedrich, Christoph M.
A1  - Engels, Christoph
A1  - Amirkhanyan, Aragats
A1  - van der Walt, Estée
A1  - Eloff, J. H. P.
A1  - Scheuermann, Bernd
A1  - Weinknecht, Elisa
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Oswald, Gerhard
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Schulzki, Bernhard
T1  - HPI Future SOC Lab
BT  - Proceedings 2015
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor.
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516
ER  - 
TY  - JOUR
A1  - Paz, Cristian
A1  - Heydenreich, Matthias
A1  - Schmidt, Bernd
A1  - Vadra, Nahir
A1  - Baggio, Ricardo
T1  - Three new dihydro-beta-agarofuran sesquiterpenes from the seeds of Maytenus boaria
JF  - Acta Crystallographica Section C
N2  - As part of a project studying the secondary metabolites extracted from the Chilean flora, we report herein three new beta-agarofuran sesquiterpenes, namely (1S,4S,5S,6R,7R,8R,9R,10S)-6-acetoxy-4,9-dihydroxy-2,2,5a,9-tetramethyloctahydro-2H-3,9a-methanobenzo[b] oxepine-5,10-diylbis(furan-3-carboxylate), C27H32O11, (II), (1S,4S,5S,6R,7R,9S,10S)-6-acetoxy-9-hydroxy-2,2,5a, 9-tetramethyloctahydro-2H-3,9a-methanobenzo[ b] oxepine-5,10-diyl bis(furan-3-carboxylate), C27H32O10, (III), and (1S,4S,5S,6R,7R,9S,10S)-6-acetoxy-10-(benzoyloxy)-9-hydroxy-2,2,5a,9-tetramethyloctahydro-2H-3,9a-methanobenzo[b]oxepin-5-yl furan-3-carboxylate, C29H34O9, (IV), obtained from the seeds of Maytenus boaria and closely associated with a recently published relative [Paz et al. (2017). Acta Cryst. C73, 451-457]. In the (isomorphic) structures of (II) and (III), the central decalin system is esterified with an acetate group at site 1 and furoate groups at sites 6 and 9, and differ at site 8, with an OH group in (II) and no substituent in (III). This position is also unsubstituted in (IV), with site 6 being occupied by a benzoate group. The chirality of the skeletons is described as 1S, 4S, 5S, 6R, 7R, 8R, 9R, 10S in (II) and 1S, 4S, 5S, 6R, 7R, 9S, 10S in (III) and (IV), matching the chirality suggested by NMR studies. This difference in the chirality sequence among the title structures (in spite of the fact that the three skeletons are absolutely isostructural) is due to the differences in the environment of site 8, i.e. OH in (II) and H in (III) and (IV). This diversity in substitution, in turn, is responsible for the differences in the hydrogen-bonding schemes, which is discussed.
KW  - Celastraceae
KW  - Maytenus boaria
KW  - sesquiterpene
KW  - dihydro-beta-agarofuran
KW  - crystal structure
KW  - NMR
KW  - DSC
Y1  - 2018
U6  - https://doi.org/10.1107/S2053229618005429
SN  - 2053-2296
VL  - 74
SP  - 564
EP  - 570
PB  - International Union of Crystallography
CY  - Chester
ER  - 
TY  - JOUR
A1  - Wilke, Max
A1  - Schmidt, Christian
A1  - Farges, Francois
A1  - Malavergne, Valerie
A1  - Gautron, Laurent
A1  - Simionovici, Alexandre
A1  - Hahn, Matthias
A1  - Petit, Pierre-Emanuel
T1  - Structural environment of iron in hydrous aluminosilicate glass and melt-evidence from X-ray absorption spectroscopy
N2  - The iron speciation in hydrous haplotonalitic and haplogranitic silicate glasses was studied using XAFS spectroscopy and transmission electron microscopy (TEM). Spectral features occurring at the main crest of the XANES at the iron K-edge of hydrous glasses indicate contributions to the spectra by iron-moieties present in a more ordered structural environment than found in the dry glass. These differences are also suggested by analysis of the EXAFS. These effects are not completely suppressed even for those samples that were quenched with a higher cooling rate. Strongest differences to the dry glass are observed for a sample that was quenched slowly through the temperature of glass transformation. Crystals (60 to 1500 nm in size) of magnetite, maghemite and another unidentified phase were observed in this sample by TEM, whereas no crystals were found in samples quenched with regular or high cooling rates. In-situ XANES measurements up to 700 degrees C and 500 MPa were performed to reveal the origin (i.e., during synthesis or quench) of the structural differences for those hydrous glasses that do not display any detectable crystallization. The comparison of XANES spectra collected on Fe2+ in water-saturated haplogranitic melt at 700 degrees C and 500 MPa and on Fe2+ in dry melt at 1150 degrees C shows that the local structural environment of Fe2+ in both systems is similar. This indicates that there is no detectable and direct influence of water on the local structure around iron in this type of melt. Hence, the differences observed between hydrous and dry glasses can only be related to artefacts formed during the quench process. (c) 2006 Elsevier B.V. All rights reserved
Y1  - 2006
U6  - https://doi.org/10.1016/j.chemgeo.2006.01.017
ER  - 
TY  - JOUR
A1  - Meyer, Rhonda C.
A1  - Witucka-Wall, Hanna
A1  - Becher, Martina
A1  - Blacha, Anna Maria
A1  - Boudichevskaia, Anastassia
A1  - Dörmann, Peter
A1  - Fiehn, Oliver
A1  - Friedel, Svetlana
A1  - von Korff, Maria
A1  - Lisec, Jan
A1  - Melzer, Michael
A1  - Repsilber, Dirk
A1  - Schmidt, Renate
A1  - Scholz, Matthias
A1  - Selbig, Joachim
A1  - Willmitzer, Lothar
A1  - Altmann, Thomas
T1  - Heterosis manifestation during early Arabidopsis seedling development is characterized by intermediate gene expression and enhanced metabolic activity in the hybrids
JF  - The plant journal
N2  - Heterosis-associated cellular and molecular processes were analyzed in seeds and seedlings of Arabidopsis thaliana accessions Col-0 and C24 and their heterotic hybrids. Microscopic examination revealed no advantages in terms of hybrid mature embryo organ sizes or cell numbers. Increased cotyledon sizes were detectable 4 days after sowing. Growth heterosis results from elevated cell sizes and numbers, and is well established at 10 days after sowing. The relative growth rates of hybrid seedlings were most enhanced between 3 and 4 days after sowing. Global metabolite profiling and targeted fatty acid analysis revealed maternal inheritance patterns for a large proportion of metabolites in the very early stages. During developmental progression, the distribution shifts to dominant, intermediate and heterotic patterns, with most changes occurring between 4 and 6 days after sowing. The highest incidence of heterotic patterns coincides with establishment of size differences at 4 days after sowing. In contrast, overall transcript patterns at 4, 6 and 10 days after sowing are characterized by intermediate to dominant patterns, with parental transcript levels showing the largest differences. Overall, the results suggest that, during early developmental stages, intermediate gene expression and higher metabolic activity in the hybrids compared to the parents lead to better resource efficiency, and therefore enhanced performance in the hybrids.
KW  - heterosis
KW  - seedlings
KW  - metabolite profiling
KW  - transcript profiling
KW  - morphological analysis
KW  - Arabidopsis thaliana
KW  - biomass
Y1  - 2012
U6  - https://doi.org/10.1111/j.1365-313X.2012.05021.x
SN  - 0960-7412
VL  - 71
IS  - 4
SP  - 669
EP  - 683
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Keller, Matthias
A1  - Lenz, Daniel
A1  - Schmidt, Marcel
A1  - Schwarz, Michael
T1  - Boundary representation of Dirichlet forms on discrete spaces
JF  - Journal de Mathématiques Pures et Appliquées
N2  - We describe the set of all Dirichlet forms associated to a given infinite graph in terms of Dirichlet forms on its Royden boundary. Our approach is purely analytical and uses form methods. (C) 2018 Elsevier Masson SAS.
KW  - Dirichlet form
KW  - Royden boundary
KW  - Infinite graph
KW  - Harmonic measure
KW  - Trace Dirichlet form
Y1  - 2019
U6  - https://doi.org/10.1016/j.matpur.2018.10.005
SN  - 0021-7824
SN  - 1776-3371
VL  - 126
SP  - 109
EP  - 143
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arias, Hugo R.
A1  - Feuerbach, Dominik
A1  - Schmidt, Bernd
A1  - Heydenreich, Matthias
A1  - Paz, Cristian
A1  - Ortells, Marcelo O.
T1  - Drimane Sesquiterpenoids Noncompetitively Inhibit Human alpha 4 beta 2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human alpha 3 beta 4 and alpha 7 Subtypes
JF  - Journal of natural products
N2  - The drimane sesquiterpenoids drimenin, cinnamolide, dendocarbin A, and polygodial were purified from the Canelo tree (Drimys winteri) and chemically characterized by spectroscopic methods. The pharmacological activity of these natural compounds were determined on hα4β2, hα3β4, and hα7 nicotinic acetylcholine receptors (AChRs) by Ca2+ influx measurements. The results established that drimane sesquiterpenoids inhibit AChRs with the following selectivity: hα4β2 > hα3β4 > hα7. In the case of hα4β2 AChRs, the following potency rank order was determined (IC50’s in μM): drimenin (0.97 ± 0.35) > cinnamolide (1.57 ± 0.36) > polygodial (62.5 ± 19.9) ≫ dendocarbin A (no activity). To determine putative structural features underlying the differences in inhibitory potency at hα4β2 AChRs, additional structure–activity relationship and molecular docking experiments were performed. The Ca2+ influx and structural results supported a noncompetitive mechanism of inhibition, where drimenin interacted with luminal and nonluminal (TMD-β2 intrasubunit) sites. The structure–activity relationship results, i.e., the lower the ligand polarity, the higher the inhibitory potency, supported the nonluminal interaction. Ligand binding to both sites might inhibit the hα4β2 AChR by a cooperative mechanism, as shown experimentally (nH > 1). Drimenin could be used as a molecular scaffold for the development of more potent inhibitors with higher selectivity for the hα4β2 AChR.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.jnatprod.7b00893
SN  - 0163-3864
SN  - 1520-6025
VL  - 81
IS  - 4
SP  - 811
EP  - 817
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Mangelsdorf, Birgit
A1  - Horn-Conrad, Antje
A1  - Bagdahn, Christian
A1  - Schmidt, Bernd
A1  - Eckardt, Barbara
A1  - Görlich, Petra
A1  - Peter, Andreas
A1  - Pösl, Thomas
A1  - Nestler, Ralf
A1  - Zimmermann, Matthias
T1  - Portal = Wenn die Chemie stimmt: Lösungen für heute und morgen
T2  - Das Potsdamer Universitätsmagazin
N2  - Aus dem Inhalt:
- Wenn die Chemie stimmt: Lösungen für heute und morgen
- Das Kreuz mit dem Kreuz
- „Das verrückteste Jahr unseres Lebens“
T3  - Portal: Das Potsdamer Universitätsmagazin - 03/2011 
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-459810
SN  - 1618-6893
IS  - 03/2011
ER  - 
TY  - JOUR
A1  - Minnes, Mark
A1  - Rüter, Sebastian
A1  - Glahn, Julia
A1  - Schmieder, Carsten
A1  - Engelhardt, Kay
A1  - Helbig, Muriel
A1  - Scholz, Matthias
A1  - Polok, Darius
A1  - Latuske, Jörg
A1  - Schmidt, Anja
A1  - Stab, Uwe
A1  - Francke, Christian
A1  - Böhringer, Bianca
A1  - Kubala, Alida
A1  - Haack, Jan an
T1  - Portal alumni
T2  - Das Ehemaligen-Magazin der Universität Potsdam
N2  - Liebe Leserin, lieber Leser, wenn es nach der Bundesfamilienrninisterin geht, soll Deutschland eines der familienfreundlichsten Länder in Europa werden. Noch sieht die Realität allerdings anders aus. Wie Ehemalige sich zwischen familiären und beruflichen Optionen entschieden haben, welche Probleme sie zu bewältigen hatten und welche Lösungen sie fanden, davon berichten sie in unserem Titelthema. Jede dritte Akademikerin bleibt heute in Deutschland kinderlos, Tendenz steigend. Abgesehen davon, dass es auch schlichtweg Lebensentwürfe ohne Kinder gibt: Ein nicht unwesentlicher Grund dafur ist sicherlich, dass die größte Last bei der Kindererziehung immer noch Frauen tragen und sie deshalb auch die größeren Einbußen in ihrer Karriere haben. So herrscht bei vielen Arbeitgebern das Vorurteil, Mütter in Führungspositionen wären weniger leistungsfahig. Dass aber gerade eine Familie Frauen in verantwortungsvollen Positionen den Rücken stärken und zu noch größerem Einsatz beflügeln kann, davon berichtet der einführende Artikel. Ein Beispiel dafür, dass sich Familie und eine berufliche Führungsposition vereinbaren lassen, ist auch Uni-Präsidentin, Prof. Dr.-Ing. Dr. Sabine Kunst. In einem Interview verrät sie ihr ganz persönliches Erfolgsrezept und stellt außerdem die strategische Ausrichtung der Hochschule in den nächsten Jahren vor. Wenn Sie Ihre Erfahrungen zu unserem Titelthema mit anderen Ehemaligen diskutieren wollen, können Sie dies unter .. Forum" in unserem "alumni-portal" tun. Wie immer freuen wir uns auf Ihre Meinung zur vorliegenden Ausgabe von ,,Portal alurnni" und wünschen Ihnen viele Vergnügen beim Lesen. Viele Grüße aus Potsdam, Ihr Alumni-Team.
N2  - Dear readers, if the Federal Ministry for Family Affairs has its way, then Germany should become one ofthe most family friendly countries in Europe. However, today's reality shows a much different picture. ln our cover story, alumni report on how they have decided between familial and professional options as weil as on the problems solved along the way, and those yet to be mastered. One-third of all warnen with academic degrees do not have children. Not disregarding that there are paths in life which simply do not include having children, an important reason for this tendency lies without doubt in the fact that warnen still continue to carry the largest burden in the childrearing process, and that they therefore experience more serious Iosses regarding their professional careers than their male counterparts. For example, bias against mothers in leadership positions, due to their supposed reduced productivity, is still widely held by employers. The main article of our cover story shows that it is especially the family which can support warnen in positions of responsibility. The university's president, Prof Dr.-lng. Dr. Sabine Kunst, provides us with one prominent example of the compatibility offamily and a professionalleadership position. ln an intenview she reveals her personal recipe for success - and discusses the strategic development of the university in the years to come. lf you would like to discuss your experiences regarding family and professionallife with other alumni, please feel free to do so in the "forum" on our "alumni-portal". As always, we hope you enjoy reading this issue of the "Portal alumni" and appreciate your feedback. With best regards from Potsdam, Your Alumni Team.
T3  - Portal alumni : das Ehemaligen-Magazin der Universität Potsdam - 7/2009 
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-482420
VL  - 2009
IS  - 7
EP  - 59
ER  - 
TY  - JOUR
A1  - Song, Hui
A1  - Bergstrasser, Claudia
A1  - Rafat, Neysan
A1  - Hoeger, Simone
A1  - Schmidt, Marc
A1  - Endres, N.
A1  - Goebeler, Matthias
A1  - Hillebrands, Jan-Luuk
A1  - Brigelius-Flohé, Regina
A1  - Banning, Antje
A1  - Beck, Grietje
A1  - Loesel, Ralf
A1  - Yard, Benito A.
T1  - The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E- selectin independently of haem oxygenase-1 expression
N2  - Background and purpose: Although carbon monoxide (CO) can modulate inflammatory processes, the influence of CO on adhesion molecules is less clear. This might be due to the limited amount of CO generated by haem degradation. We therefore tested the ability of a CO releasing molecule (CORM-3), used in supra-physiological concentrations, to modulate the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin on endothelial cells and the mechanism(s) involved. Experimental approach: Human umbilical vein endothelial cells (HUVECs) were stimulated with tumour necrosis factor (TNF)-alpha in the presence or absence of CORM-3. The influence of CORM-3 on VCAM-1 and E- selectin expression and the nuclear factor (NF)-kappa B pathway was assessed by flow cytometry, Western blotting and electrophoretic mobility shift assay. Key results: CORM-3 inhibited the expression of VCAM-1 and E-selectin on TNF-alpha- stimulated HUVEC. VCAM-1 expression was also inhibited when CORM-3 was added 24 h after TNF-alpha stimulation or when TNF-alpha was removed. This was paralleled by deactivation of NF-kappa B and a reduction in VCAM-1 mRNA. Although TNF- alpha removal was more effective in this regard, VCAM-1 protein was down-regulated more rapidly when CORM-3 was added. CORM-3 induced haem oxygenase-1 (HO-1) in a dose- and time-dependent manner, mediated by the transcription factor, Nrf2. CORM-3 was still able to down-regulate VCAM-1 expression in HUVEC transfected with siRNA for HO-1 or Nrf2. Conclusions and implications: Down-regulation of VCAM and E-selectin expression induced by CORM-3 was independent of HO-1 up- regulation and was predominantly due to inhibition of sustained NF-kappa B activation.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/journal/121548564/home
U6  - https://doi.org/10.1111/j.1476-5381.2009.00215.x
SN  - 0007-1188
ER  - 
TY  - JOUR
A1  - Paz, Cristian
A1  - Becerra, Jose
A1  - Silva, Mario
A1  - Burgos, Viviana
A1  - Heydenreich, Matthias
A1  - Schmidt, Bernd
A1  - Thu Tran, 
A1  - Vetter, Irina
T1  - (-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor
JF  - Natural product communications : an international journal for communications and reviews
N2  - Lobelia tupa, also called devil's tobacco, is a native plant from the center-south of Chile which has been used by the native people of Chile as a hallucinogenic and anesthetic plant. A new piperidine alkaloid, called pentylsedinine, which comprises five carbons in the side chain, was isolated from the aerial part of L. tupa, along with lobeline and lobelanidine. The structure was established on the basis of 1D and 2D NMR spectroscopy. While lobeline is a neutral antagonist at alpha 3 beta 2/alpha 3 beta 4 nAChR and alpha 7 nAChR, both lobelanidine and pentylsedinine act as partial agonists at nAChR
KW  - Lobelia tupa
KW  - Piperidine alkaloid
KW  - nAChR
KW  - Pentylsedinine
Y1  - 2015
SN  - 1934-578X
SN  - 1555-9475
VL  - 10
IS  - 8
SP  - 1355
EP  - 1357
PB  - NPC
CY  - Westerville
ER  - 
TY  - JOUR
A1  - Keller, Matthias
A1  - Lenz, Daniel
A1  - Münch, Florentin
A1  - Schmidt, Marcel
A1  - Telcs, Andras
T1  - Note on short-time behavior of semigroups associated to self-adjoint operators
JF  - Bulletin of the London Mathematical Society
N2  - We present a simple observation showing that the heat kernel on a locally finite graph behaves for short times t roughly like t(d), where d is the combinatorial distance. This is very different from the classical Varadhan-type behavior on manifolds. Moreover, this also gives that short-time behavior and global behavior of the heat kernel are governed by two different metrics whenever the degree of the graph is not uniformly bounded.
Y1  - 2016
U6  - https://doi.org/10.1112/blms/bdw054
SN  - 0024-6093
SN  - 1469-2120
VL  - 48
SP  - 935
EP  - 944
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Paz, Cristian
A1  - Becerra, Jose
A1  - Silva, Mario
A1  - Cabrera-Pardo, Jaime
A1  - Burgos, Viviana
A1  - Heydenreich, Matthias
A1  - Schmidt, Bernd
T1  - (-)-8-Oxohobartine a New Indole Alkaloid from Aristotelia chilensis (Mol.) Stuntz
JF  - Records of Natural Products
N2  - The fruit of Aristotelia chilensis is considered a "super fruit" due to its high concentration of polyphenols displaying exceptional antioxidant capacities ORAC. From maqui berries have been reported several anthocyanins and glycosylated flavonoids, those benefits increase the attention to restudy the plant. From the leaves of A. chilensis several indole alkaloids have been reported, we in addition to aristoteline, aristone, aristoquinoline and 3-fromylindole report the spectroscopic elucidation of 8-oxo-9-dehydromakomakine (1), hobartine (2) and a new alkaloid named 8-oxohobartine (3). Compound 1 to 3 did not show bactericidal activity against E. coli and S. aureus till 200 mu g.
KW  - Aristotelia chilensis
KW  - indole alkaloids
KW  - 8-oxohobartine
Y1  - 2016
SN  - 1307-6167
VL  - 10
SP  - 68
EP  - 73
PB  - ACG Publications
CY  - Gebze-Kocaeli
ER  - 
TY  - CHAP
A1  - Frieß, Nina
A1  - Huber, Angela
A1  - Sproede, Alfred
A1  - Engel, Christine
A1  - Schwartz, Matthias
A1  - Brylla, Wolfgang
A1  - Kunow, Rüdiger
A1  - Kirjuchina, Ljuba
A1  - Günther, Clemens
A1  - Jekutsch, Ulrike
A1  - Wehrhahn, Olena
A1  - Düring, Michael
A1  - Smyshliaeva, Maria
A1  - Schmidt, Nora
A1  - Hansen-Kokoruš, Renate
A1  - Gladis, Lea
A1  - Soldat, Cornelia
ED  - Frieß, Nina
ED  - Huber, Angela
T1  - Investigation – Rekonstruktion – Narration
BT  - Geschichten und Geschichte im Krimi der Slavia
N2  - Kriminalliteratur gilt als zuverlässiger Seismograph für den inneren Zustand einer Gesellschaft, deren Umgang mit der Abweichung von der Norm zum Indikator sozialer und politischer Verhältnisse wird. Die gemeinsame Vergangenheit eint und trennt die Staaten Ostmittel-, Ost- und Südosteuropas gleichermaßen. Die schicksalhaften Verwerfungen des 20. Jahrhunderts fanden natürlich auch Eingang in die jeweiligen Kriminalliteraturen. So vielgestaltig wie die einzelnen Länder und Regionen sind die im vorliegenden Band untersuchten Texte. Sie ermöglichen einerseits Einblicke in den Herausbildungs- und Etablierungsprozess der Kriminalliteratur der Slavia. Andererseits bilden sie aktuelle Entwicklungen dieses ebenso populären wie zeitlosen Genres ab.

Das literarische Verbrechen hat Prof. Dr. Norbert P. Franz während seines aktiven akademischen Wirkens immer begleitet. Ihm zu Ehren fand im Frühjahr 2017 an der Universität Potsdam eine wissenschaftliche Tagung statt, deren Beiträge in diesem Band zusammengestellt sind.
N2  - Crime fiction is a reliable gauge for a society’s inner condition. How a society deals with deviation is an indicator for its social and political environment. The common past unites and separates the states of Eastern Europe at the same time. Naturally, the fateful events of the 20th century found their way into the countries’ crime fiction. The literary texts analysed in this volume are as manifold as the countries and regions they deal with. On the one hand, the articles give an overview of the process of development and establishment of crime fiction in selected Slavic countries. On the other hand, they show current developments of this popular genre.
KW  - Kriminalroman
KW  - Krimi
KW  - Verbrechen
KW  - Narration
KW  - Slavistik
KW  - crime fiction
KW  - crime
KW  - narration
KW  - slavic studies
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-413176
SN  - 978-3-86956-446-3
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Munz, Matthias
A1  - Schmidt, Christian
T1  - Estimation of vertical water fluxes from temperature time series by the inverse numerical computer program FLUX-BOT
JF  - Hydrological processes
N2  - The application of heat as a hydrological tracer has become a standard method for quantifying water fluxes between groundwater and surface water. The typical application is to estimate vertical water fluxes in the shallow subsurface beneath streams or lakes. For this purpose, time series of temperatures in the surface water and in the sediment are measured and evaluated by a vertical 1D representation of heat transport by advection and conduction. Several analytical solutions exist to calculate the vertical water flux from the measured temperatures. Although analytical solutions can be easily implemented, they are restricted to specific boundary conditions such as a sinusoidal upper temperature boundary. Numerical solutions offer higher flexibility in the selection of the boundary conditions. This, in turn, reduces the effort of data preprocessing, such as the extraction of the diurnal temperature variation from the raw data. Here, we present software to estimate water fluxes based on temperaturesFLUX-BOT. FLUX-BOT is a numerical code written in MATLAB that calculates vertical water fluxes in saturated sediments based on the inversion of measured temperature time series observed at multiple depths. FLUX-BOT applies a centred Crank-Nicolson implicit finite difference scheme to solve the one-dimensional heat advection-conduction equation. FLUX-BOT includes functions for the inverse numerical routines, functions for visualizing the results, and a function for performing uncertainty analysis. We present applications of FLUX-BOT to synthetic and to real temperature data to demonstrate its performance.
KW  - heat tracing
KW  - numerical solution
KW  - surface water groundwater interaction
KW  - temperature time series
KW  - vertical water flux
Y1  - 2017
U6  - https://doi.org/10.1002/hyp.11198
SN  - 0885-6087
SN  - 1099-1085
VL  - 31
SP  - 2713
EP  - 2724
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Günther, Oliver
A1  - Zimmermann, Matthias
A1  - Kampe, Heike
A1  - Scholz, Jana
A1  - Eckardt, Barbara
A1  - Schmidt, Anna Theresa
A1  - Görlich, Petra
A1  - Lux, Nadine
A1  - Szameitat, Ulrike
A1  - Ziemer, Franziska
A1  - Jäger, Heidi
A1  - Rost, Sophia
T1  - Portal = Konzepte und Visionen: Städte der Zukunft
BT  - Das Potsdamer Universitätsmagazin
N2  - Aus dem Inhalt:
- Konzepte und Visionen: Städte der Zukunft
- Uni plant Entwicklung bis 2018
- Was glänzt und was fehlt
T3  - Portal: Das Potsdamer Universitätsmagazin - 01/2015 
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440624
SN  - 1618-6893
IS  - 01/2015
ER  - 
TY  - BOOK
A1  - Schwarzer, Ingo
A1  - Weiß-Saoumi, Said
A1  - Kittel, Roland
A1  - Friedrich, Tobias
A1  - Kaynak, Koraltan
A1  - Durak, Cemil
A1  - Isbarn, Andreas
A1  - Diestel, Jörg
A1  - Knittel, Jens
A1  - Franz, Marquart
A1  - Morra, Carlos
A1  - Stahnke, Susanne
A1  - Braband, Jens
A1  - Dittmann, Johannes
A1  - Griebel, Stephan
A1  - Krampf, Andreas
A1  - Link, Martin
A1  - Müller, Matthias
A1  - Radestock, Jens
A1  - Strub, Leo
A1  - Bleeke, Kai
A1  - Jehl, Leander
A1  - Kapitza, Rüdiger
A1  - Messadi, Ines
A1  - Schmidt, Stefan
A1  - Schwarz-Rüsch, Signe
A1  - Pirl, Lukas
A1  - Schmid, Robert
A1  - Friedenberger, Dirk
A1  - Beilharz, Jossekin Jakob
A1  - Boockmeyer, Arne
A1  - Polze, Andreas
A1  - Röhrig, Ralf
A1  - Schäbe, Hendrik
A1  - Thiermann, Ricky
T1  - RailChain
BT  - Abschlussbericht
N2  - The RailChain project designed, implemented, and experimentally evaluated a juridical recorder that is based on a distributed consensus protocol. That juridical blockchain recorder has been realized as distributed ledger on board the advanced TrainLab (ICE-TD 605 017) of Deutsche Bahn.
For the project, a consortium consisting of DB Systel, Siemens, Siemens Mobility, the Hasso Plattner Institute for Digital Engineering, Technische Universität Braunschweig, TÜV Rheinland InterTraffic, and Spherity has been formed. These partners not only concentrated competencies in railway operation, computer science, regulation, and approval, but also combined experiences from industry, research from academia, and enthusiasm from startups.
Distributed ledger technologies (DLTs) define distributed databases and express a digital protocol for transactions between business partners without the need for a trusted intermediary. The implementation of a blockchain with real-time requirements for the local network of a railway system (e.g., interlocking or train) allows to log data in the distributed system verifiably in real-time. For this, railway-specific assumptions can be leveraged to make modifications to standard blockchains protocols.
EULYNX and OCORA (Open CCS On-board Reference Architecture) are parts of a future European reference architecture for control command and signalling (CCS, Reference CCS Architecture – RCA). Both architectural concepts outline heterogeneous IT systems with components from multiple manufacturers. Such systems introduce novel challenges for the approved and safety-relevant CCS of railways which were considered neither for road-side nor for on-board systems so far. Logging implementations, such as the common juridical recorder on vehicles, can no longer be realized as a central component of a single manufacturer. All centralized approaches are in question.
The research project RailChain is funded by the mFUND program and gives practical evidence that distributed consensus protocols are a proper means to immutably (for legal purposes) store state information of many system components from multiple manufacturers. The results of RailChain have been published, prototypically implemented, and experimentally evaluated in large-scale field tests on the advanced TrainLab. At the same time, the project showed how RailChain can be integrated into the road-side and on-board architecture given by OCORA and EULYNX.
Logged data can now be analysed sooner and also their trustworthiness is being increased. This enables, e.g., auditable predictive maintenance, because it is ensured that data is authentic and unmodified at any point in time.
N2  - Das Projekt RailChain hat einen verteilten Juridical Recorder entworfen, implementiert und experimentell evaluiert, der auf einem echtzeitfähigen verteilten Konsensprotokoll basiert. Dieser Juridical Blockchain Recorder wurde als distributed ledger an Bord des advanced TrainLabs der Deutschen Bahn (ICE-TD 605 017) umgesetzt.
Für das Projekt hat sich ein Konsortium aus DB Systel, Siemens, Siemens Mobility, dem Hasso-Plattner-Institut für Digital Engineering, der Technischen Universität Braunschweig, sowie TÜV Rheinland InterTraffic und Spherity formiert und dabei Kompetenzen aus den Bereichen Bahnbetrieb, Informatik und Zulassungswesen gebündelt. Die Partner kombinieren Erfahrungen aus der Industrie und die akademische Forschung mit der Aufbruchstimmung aus dem Start-Up-Umfeld.
Distributed-Ledger-Technologien (DLTs) definieren verteilte Datenbanken und stellen ein digitales Protokoll für Transaktionen zwischen Geschäftspartnern dar, ohne dass ein Mittelsmann beteiligt sein müsste. Die Implementierung einer Blockchain mit Echtzeitanforderungen für das lokale Netzwerk einer Eisenbahnanlage (z. B. Stellwerk oder Zug) erlaubt es, die im verteilten System entstehenden Daten nachweislich in Echtzeit zu protokollieren. Dabei können eisenbahnspezifische Randbedingungen ausgenutzt werden, um Standard-Blockchain-Protokolle anzupassen.
EULYNX und OCORA (Open CCS On-board Reference Architecture) sind Bestandteile einer zukünftigen europäischen Referenzarchitektur für das Leit- und Sicherungssystem (Reference CCS Architecture – RCA, Control Command and Signalling – CCS). Beide Architekturkonzepte skizzieren herstellerübergreifende, komponentenbasierende heterogene IT-Systeme. Solche Systeme bergen neue Herausforderungen, die bislang im Kontext der zugelassenen, sicherheitsrelevanten Leit- und Sicherungstechnik der Bahn weder strecken- noch fahrzeugseitig adressiert werden mussten. Logbuch-Implementierungen, wie der gängige Juridical Recorder auf Fahrzeugen, können nun nicht mehr als zentrale Systemkomponente eines einzelnen Herstellers umgesetzt werden. Alle zentralisierten Lösungsansätze sind in Frage gestellt.
Das mFUND-geförderte Forschungsprojekt erbringt den praktischen Nachweis, dass Zustandsinformationen über eine Vielzahl von Systemkomponenten herstellerübergreifend und gerichtsfest mittels verteilten Konsensprotokollen gespeichert werden können. Ergebnisse von RailChain wurden publiziert, prototypisch implementiert und in großen Feldtests auf dem advanced TrainLab experimentell evaluiert. Gleichzeitig wurde aufgezeigt, wie sich RailChain in den mit OCORA und EULYNX vorgegebenen fahrzeug- und streckenseitigen Architekturentwurf integrieren lässt.
Daten können dadurch zeitnaher ausgewertet werden und gleichzeitig wird ihre Vertrauenswürdigkeit erhöht. Dies ermöglicht u. a. nachvollziehbare zustandsorientierte Wartung, denn es kann jederzeit sichergestellt werden, dass die Daten authentisch sind und auch nicht verändert wurden.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 152 
KW  - Distributed-Ledger-Technologie (DLT)
KW  - juridical recording
KW  - Konsensprotokolle
KW  - consensus protocols
KW  - Digitalisierung
KW  - digitalization
KW  - Bahnwesen
KW  - railways
KW  - Blockchain
KW  - asset management
KW  - selbstbestimmte Identitäten
KW  - self-sovereign identity
KW  - dezentrale Identitäten
KW  - decentral identities
KW  - überprüfbare Nachweise
KW  - verifiable credentials
KW  - Echtzeit
KW  - real-time
KW  - Standardisierung
KW  - standardization
KW  - Verlässlichkeit
KW  - dependability
KW  - Fehlertoleranz
KW  - fault tolerance
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-577409
SN  - 978-3-86956-550-7
SN  - 1613-5652
SN  - 2191-1665
IS  - 152
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Alnemr, Rehab
A1  - Polyvyanyy, Artem
A1  - AbuJarour, Mohammed
A1  - Appeltauer, Malte
A1  - Hildebrandt, Dieter
A1  - Thomas, Ivonne
A1  - Overdick, Hagen
A1  - Schöbel, Michael
A1  - Uflacker, Matthias
A1  - Kluth, Stephan
A1  - Menzel, Michael
A1  - Schmidt, Alexander
A1  - Hagedorn, Benjamin
A1  - Pascalau, Emilian
A1  - Perscheid, Michael
A1  - Vogel, Thomas
A1  - Hentschel, Uwe
A1  - Feinbube, Frank
A1  - Kowark, Thomas
A1  - Trümper, Jonas
A1  - Vogel, Tobias
A1  - Becker, Basil
ED  - Meinel, Christoph
ED  - Plattner, Hasso
ED  - Döllner, Jürgen Roland Friedrich
ED  - Weske, Mathias
ED  - Polze, Andreas
ED  - Hirschfeld, Robert
ED  - Naumann, Felix
ED  - Giese, Holger
T1  - Proceedings of the 4th Ph.D. Retreat of the HPI Research School on Service-oriented Systems Engineering
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 31 
KW  - Hasso-Plattner-Institut
KW  - Forschungskolleg
KW  - Klausurtagung
KW  - Service-oriented Systems Engineering
KW  - Hasso Plattner Institute
KW  - Research School
KW  - Ph.D. Retreat
KW  - Service-oriented Systems Engineering
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-40838
SN  - 978-3-86956-036-6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Wisotzki, Lutz
A1  - Bacon, R.
A1  - Brinchmann, J.
A1  - Cantalupo, S.
A1  - Richter, Philipp
A1  - Schaye, J.
A1  - Schmidt, Kasper Borello
A1  - Urrutia, Tanya
A1  - Weilbacher, Peter Michael
A1  - Akhlaghi, M.
A1  - Bouche, N.
A1  - Contini, T.
A1  - Guiderdoni, B.
A1  - Herenz, E. C.
A1  - Inami, H.
A1  - Kerutt, Josephine Victoria
A1  - Leclercq, F.
A1  - Marino, R. A.
A1  - Maseda, M.
A1  - Monreal-Ibero, A.
A1  - Nanayakkara, T.
A1  - Richard, J.
A1  - Saust, R.
A1  - Steinmetz, Matthias
A1  - Wendt, Martin
T1  - Nearly all the sky is covered by Lyman-alpha emission around high-redshift galaxies
JF  - Nature : the international weekly journal of science
N2  - Galaxies are surrounded by large reservoirs of gas, mostly hydrogen, that are fed by inflows from the intergalactic medium and by outflows from galactic winds. Absorption-line measurements along the lines of sight to bright and rare background quasars indicate that this circumgalactic medium extends far beyond the starlight seen in galaxies, but very little is known about its spatial distribution. The Lyman-alpha transition of atomic hydrogen at a wavelength of 121.6 nanometres is an important tracer of warm (about 104 kelvin) gas in and around galaxies, especially at cosmological redshifts greater than about 1.6 at which the spectral line becomes observable from the ground. Tracing cosmic hydrogen through its Lyman-a emission has been a long-standing goal of observational astrophysics(1-3), but the extremely low surface brightness of the spatially extended emission is a formidable obstacle. A new window into circumgalactic environments was recently opened by the discovery of ubiquitous extended Lyman-alpha emission from hydrogen around high-redshift galaxies(4,5). Such measurements were previously limited to especially favourable systems(6-8) or to the use of massive statistical averaging(9,10) because of the faintness of this emission. Here we report observations of low-surface-brightness Lyman-alpha emission surrounding faint galaxies at redshifts between 3 and 6. We find that the projected sky coverage approaches 100 per cent. The corresponding rate of incidence (the mean number of Lyman-alpha emitters penetrated by any arbitrary line of sight) is well above unity and similar to the incidence rate of high-column-density absorbers frequently detected in the spectra of distant quasars(11-14). This similarity suggests that most circumgalactic atomic hydrogen at these redshifts has now been detected in emission.
Y1  - 2018
U6  - https://doi.org/10.1038/s41586-018-0564-6
SN  - 0028-0836
SN  - 1476-4687
VL  - 562
IS  - 7726
SP  - 229
EP  - 232
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Horn-Conrad, Antje
A1  - Seip, Juliane
A1  - Liebig, Ferenc
A1  - Engel, Silke
A1  - Schuster, Stefanie
A1  - Jung, Karina
A1  - Aust, Sarah-Madeleine
A1  - Kampe, Heike
A1  - Lentz, Christine
A1  - Mikulla, Stefanie
A1  - Zimmermann, Matthias
A1  - Agrofylax, Luisa
A1  - Scholz, Jana
A1  - Schmidt, Debby
T1  - Portal Transfer
BT  - Alumni- und Transfermagazin der Universität Potsdam
N2  - Liebe Leserinnen und Leser, kein Nachrichtentag vergeht, an dem nicht die Expertise aus der Wissenschaft gefragt ist: Ob zum russischen Angriffskrieg in der Ukraine, zur UNKlimakonferenz in Ägypten, zur Flutkatastrophe in Pakistan, zum Dürresommer, zur Energiekrise, selbst zur umstrittenen Fußballweltmeisterschaft in Katar standen und stehen Expertinnen und Experten in den Medien Rede und Antwort. Auch aus der Universität Potsdam. Wir haben sie gefragt, wie sie damit umgehen, wie es ihnen gelingt, aus der laufenden Forschung heraus aktuelle Probleme zu bewerten. Und was davon bleibt, wenn das öffentliche Interesse abebbt. Für die Potsdamer Politik- und Verwaltungswissenschaftlerin Sabine Kuhlmann besteht die Kunst darin, „außerhalb der Krise Ideen und Lösungsansätze zu verstetigen und sie tatsächlich in die Praxis umzusetzen“.
In unserem Alumni- und Transfermagazin berichten wir davon, was und wie die Universität Potsdam dazu beiträgt. Wir erzählen, wie Erfindungen zu Innovationen in der Wirtschaft werden und sich Start-ups auf den Weg machen, ihr Produkt selbst zu vermarkten. Das Spektrum reicht von Meeresfrüchten auf Pflanzenbasis bis zu einer App, mit der sich Frühformen der Demenz erkennen lassen. Neben neuen Technologien kommt es aber vor allem darauf an, das an der Universität erzeugte Wissen in die Praxis zu transferieren. Deshalb stellen wir ein Programm zur Bekämpfung von Hassrede in der Schule vor oder auch eine Klettertherapie zur Behandlung von Skoliose. Und wir zeigen, wie eine Studie zur sportlichen Leistungskraft von Kindern helfen kann, den Sportunterricht zu verbessern.
Den größten Teil des an der Universität produzierten Wissens tragen die Studierenden in die Welt, wenn sie nach ihrem Abschluss als Musiklehrerin in einer Schule arbeiten oder als Software-Ingenieur im eigenen Unternehmen, als Geologin nach Seltenen Erden schürfen, als Ökologe ausgelaugte Böden wieder fruchtbar machen oder als Politikerin ein Ministerium leiten. Sie alle kommen in diesem Magazin zu Wort. Oder in unserem neuen Podcast „Listen.UP“, in dem Studierende, Forschende und Alumni von ihren Transferprojekten erzählen. Von der Gründerin Ulrike Böttcher erfährt man dort zum Beispiel, wie sie mit Schnallen, Ösen und Knöpfen aus Bio- Materialien die Modeindustrie in diesem Bereich nachhaltig verändern will. Nachzulesen ist das auch in diesem Heft. Immer dort, wo das „Listen. UP“-Logo erscheint, lohnt es, zusätzlich in den Podcast hineinzuhören.
T3  - Portal Transfer : Alumni- und Transfermagazin der Universität Potsdam - 2023 
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-613650
SN  - 2747-6898
IS  - 2023
ER  - 
TY  - CHAP
A1  - Patuchova, Nadezda B.
A1  - Klein, Eckart
A1  - Franzke, Jochen
A1  - Büchner, Christiane
A1  - Doroshenko, Egor N.
A1  - Hoof, Karsten
A1  - Zenin, Sergey S.
A1  - Thiele, Carmen
A1  - Schmidt, Carmen
A1  - Fadeev, Vladimir Ivanovič
A1  - Dombert, Matthias
A1  - Sadovnikova, Galina D.
A1  - Schulze, Carola
A1  - Luchterhandt, Otto
A1  - Syuzyukina, Oxana
ED  - Fadeev, Vladimir Ivanovič
ED  - Schulze, Carola
T1  - Verfassungsentwicklung in Russland und Deutschland : Materialien des russisch-deutschen Symposiums anlässlich des 20. Jahrestages der Verfassung der Russischen Föderation am 25. und 26. September 2013 an der Universität Potsdam
T1  - Progress of constitutions in Russia and in Germany
N2  - Der Band enthält die Tagungsmaterialien des deutsch-russichen Symposiums zum Thema "Verfassungsentwicklung in Russland und Deutschland", welches am 25. und 26. September 2013 in Potsdam stattfand. Die Tagung wurde anlässlich des 20. Jahrestages der russischen Verfassung vom Dezember 2013 durchgeführt. Die inhaltlichen Schwerpunkte bilden die Themen: Verfassungsentstehung, Verfassungsänderung, Verfassungsprinzipien, Landesverfassungen, Fortentwicklung der Verfassung durch die Verfassungsgerichtsbarkeit und Grundrechte, die jeweils aus russischer und deutscher Sicht behandelt werden. Ergänzend befasst sich jeweils ein Betrag mit aktuellen Problemen der Menschenrechtsverwirklichung in Russland und der Ausländerintegration in Deutschland und Russland im Vergleich.
KW  - Verfassungsentstehung und -änderung
KW  - Verfassungsprinzipien
KW  - Verfassungsgerichtsbarkeit
KW  - Landesverfassung
KW  - Grundrechte
KW  - Integration
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70418
SN  - 978-3-86956-289-6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Olsen, Susan
A1  - Stiebels, Barbara
A1  - Bierwisch, Manfred
A1  - Zimmermann, Ilse
A1  - Cavar, Damir
A1  - Georgi, Doreen
A1  - Bacskai-Atkari, Julia
A1  - Alexiadou, Artemis
A1  - Błaszczak, Joanna
A1  - Müller, Gereon
A1  - Šimík, Radek
A1  - Meinunger, André
A1  - Thiersch, Craig
A1  - Arnhold, Anja
A1  - Féry, Caroline
A1  - Bayer, Josef
A1  - Titov, Elena
A1  - Fominyam, Henry
A1  - Tran, Thuan
A1  - Bornkessel-Schlesewsky, Ina D.
A1  - Schlesewsky, Matthias
A1  - Zimmermann, Malte
A1  - Häussler, Jana
A1  - Mucha, Anne
A1  - Schmidt, Andreas
A1  - Weskott, Thomas
A1  - Wierzba, Marta
A1  - Stede, Manfred
A1  - Skopeteas, Stavros
A1  - Gafos, Adamantios I.
A1  - Haider, Hubert
A1  - Wunderlich, Dieter
A1  - Staudacher, Peter
A1  - Rauh, Gisa
ED  - Brown, Jessica M. M.
ED  - Schmidt, Andreas
ED  - Wierzba, Marta
T1  - Of Trees and Birds
BT  - A Festschrift for Gisbert Fanselow
N2  - Gisbert Fanselow’s work has been invaluable and inspiring to many ­researchers working on syntax, morphology, and information ­structure, both from a ­theoretical and from an experimental perspective. This ­volume comprises a collection of articles dedicated to Gisbert on the occasion of his 60th birthday, covering a range of topics from these areas and beyond. The contributions have in ­common that in a broad sense they have to do with language structures (and thus trees), and that in a more specific sense they have to do with birds. They thus cover two of Gisbert’s major interests in- and outside of the linguistic world (and ­perhaps even at the interface).
KW  - Festschrift
KW  - Linguistik
KW  - Syntax
KW  - Morphologie
KW  - Informationsstruktur
KW  - festschrift
KW  - linguistics
KW  - syntax
KW  - morphology
KW  - information structure
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-426542
SN  - 978-3-86956-457-9
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Munz, Matthias
A1  - Oswald, Sascha
A1  - Schmidt, C.
T1  - Sand box experiments to evaluate the influence of subsurface temperature probe design on temperature based water flux calculation
JF  - Hydrology and earth system sciences : HESS
N2  - Quantification of subsurface water fluxes based on the one dimensional solution to the heat transport equation depends on the accuracy of measured subsurface temperatures. The influence of temperature probe setup on the accuracy of vertical water flux calculation was systematically evaluated in this experimental study. Four temperature probe setups were installed into a sand box experiment to measure temporal highly resolved vertical temperature profiles under controlled water fluxes in the range of +/- 1.3 md(-1). Pass band filtering provided amplitude differences and phase shifts of the diurnal temperature signal varying with depth depending on water flux. Amplitude ratios of setups directly installed into the saturated sediment significantly varied with sand box hydraulic gradients. Amplitude ratios provided an accurate basis for the analytical calculation of water flow velocities, which matched measured flow velocities. Calculated flow velocities were sensitive to thermal properties of saturated sediment and to temperature sensor spacing, but insensitive to thermal dispersivity equal to solute dispersivity. Amplitude ratios of temperature probe setups indirectly installed into piezometer pipes were influenced by thermal exchange processes within the pipes and significantly varied with water flux direction only. Temperature time lags of small sensor distances of all setups were found to be insensitive to vertical water flux.
Y1  - 2011
U6  - https://doi.org/10.5194/hess-15-3495-2011
SN  - 1027-5606
VL  - 15
IS  - 11
SP  - 3495
EP  - 3510
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Oloya, Benson
A1  - Namukobe, Jane
A1  - Heydenreich, Matthias
A1  - Ssengooba, Willy
A1  - Schmidt, Bernd
A1  - Byamukama, Robert
T1  - Antimycobacterial activity of the extract and isolated compounds from the stem bark of Zanthoxylum leprieurii Guill. and Perr.
JF  - Natural product communications : an international journal for communications and reviews
N2  - Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), (S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H(37)Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 mu g/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H(37)Rv) TB strain (MIC 6 mu g/mL), but moderate activity against the MDR-TB strain (MIC 12.2 mu g/mL). Compounds 2, 5, 6, and 1 showed moderate activities against the susceptible (H(37)Rv) strain (MIC 12.2-98.0 mu g/mL) and moderate to weak activities against the MDR-TB strain (MIC 24.4-195.0 mu g/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs.
KW  - tuberculosis
KW  - Zanthoxylum leprieurii
KW  - antimycobacterial activity
KW  - trans-fagaramide
KW  - alkaloid
Y1  - 2021
U6  - https://doi.org/10.1177/1934578X211035851
SN  - 1934-578X
SN  - 1555-9475
VL  - 16
IS  - 8
PB  - Sage Publ.
CY  - Thousand Oaks
ER  - 
TY  - JOUR
A1  - Rothwell, Joseph A.
A1  - Murphy, Neil
A1  - Aleksandrova, Krasimira
A1  - Schulze, Matthias Bernd
A1  - Bešević, Jelena
A1  - Kliemann, Nathalie
A1  - Jenab, Mazda
A1  - Ferrari, Pietro
A1  - Achaintre, David
A1  - Gicquiau, Audrey
A1  - Vozar, Béatrice
A1  - Scalbert, Augustin
A1  - Huybrechts, Inge
A1  - Freisling, Heinz
A1  - Prehn, Cornelia
A1  - Adamski, Jerzy
A1  - Cross, Amanda J.
A1  - Pala, Valeria Maria
A1  - Boutron-Ruault, Marie-Christine
A1  - Dahm, Christina C.
A1  - Overvad, Kim
A1  - Gram, Inger Torhild
A1  - Sandanger, Torkjel M.
A1  - Skeie, Guri
A1  - Jakszyn, Paula
A1  - Tsilidis, Kostas K.
A1  - Hughes, David J.
A1  - van Guelpen, Bethany
A1  - Bodén, Stina
A1  - Sánchez, Maria-José
A1  - Schmidt, Julie A.
A1  - Katzke, Verena
A1  - Kühn, Tilman
A1  - Colorado-Yohar, Sandra
A1  - Tumino, Rosario
A1  - Bueno-de-Mesquita, Bas
A1  - Vineis, Paolo
A1  - Masala, Giovanna
A1  - Panico, Salvatore
A1  - Eriksen, Anne Kirstine
A1  - Tjønneland, Anne
A1  - Aune, Dagfinn
A1  - Weiderpass, Elisabete
A1  - Severi, Gianluca
A1  - Chajès, Véronique
A1  - Gunter, Marc J.
T1  - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
JF  - Clinical gastroenterology and hepatology
N2  - BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.

RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants.

CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
KW  - colorectal neoplasm
KW  - risk factors
KW  - World Cancer Research Fund/American Institute for Cancer Research Recommendations
KW  - targeted metabolomics
Y1  - 2020
U6  - https://doi.org/10.1016/j.cgh.2020.11.045
SN  - 1542-3565
SN  - 1542-7714
VL  - 20
SP  - E1061
EP  - E1082
PB  - Elsevier
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Munz, Matthias
A1  - Oswald, Sascha
A1  - Schmidt, Christian
T1  - Coupled Long-Term Simulation of Reach-Scale Water and Heat Fluxes Across the River-Groundwater Interface for Retrieving Hyporheic Residence Times and Temperature Dynamics
JF  - Water resources research
N2  - Flow patterns in conjunction with seasonal and diurnal temperature variations control ecological and biogeochemical conditions in hyporheic sediments. In particular, hyporheic temperatures have a great impact on many temperature-sensitive microbial processes. In this study, we used 3-D coupled water flow and heat transport simulations applying the HydroGeoSphere code in combination with high-resolution observations of hydraulic heads and temperatures to quantify reach-scale water and heat flux across the river-groundwater interface and hyporheic temperature dynamics of a lowland gravel bed river. The model was calibrated in order to constrain estimates of the most sensitive model parameters. The magnitude and variations of the simulated temperatures matched the observed ones, with an average mean absolute error of 0.7 degrees C and an average Nash Sutcliffe efficiency of 0.87. Our results indicate that nonsubmerged streambed structures such as gravel bars cause substantial thermal heterogeneity within the saturated sediment at the reach scale. Individual hyporheic flow path temperatures strongly depend on the flow path residence time, flow path depth, river, and groundwater temperature. Variations in individual hyporheic flow path temperatures were up to 7.9 degrees C, significantly higher than the daily average (2.8 degrees C), but still lower than the average seasonal hyporheic temperature difference (19.2 degrees C). The distribution between flow path temperatures and residence times follows a power law relationship with exponent of about 0.37. Based on this empirical relation, we further estimated the influence of hyporheic flow path residence time and temperature on oxygen consumption which was found to partly increase by up to 29% in simulations.
Y1  - 2017
U6  - https://doi.org/10.1002/2017WR020667
SN  - 0043-1397
SN  - 1944-7973
VL  - 53
SP  - 8900
EP  - 8924
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Munz, Matthias
A1  - Oswald, Sascha
A1  - Schmidt, Christian
T1  - Analysis of riverbed temperatures to determine the geometry of subsurface water flow around in-stream geomorphological structures
JF  - Journal of hydrology
N2  - The analytical evaluation of diurnal temperature variation in riverbed sediments provides detailed information on exchange fluxes between rivers and groundwater. The underlying assumption of the stationary, one-dimensional vertical flow field is frequently violated in natural systems where subsurface water flow often has a significant horizontal component. In this paper, we present a new methodology for identifying the geometry of the subsurface flow field using vertical temperature profiles. The statistical analyses are based on model optimisation and selection and are used to evaluate the shape of vertical amplitude ratio profiles. The method was applied to multiple profiles measured around in-stream geomorphological structures in a losing reach of a gravel bed river. The predominant subsurface flow field was systematically categorised in purely vertical and horizontal (hyporheic, parafluvial) components. The results highlight that river groundwater exchange flux at the head, crest and tail of geomorphological structures significantly deviated from the one-dimensional vertical flow, due to a significant horizontal component. The geometry of the subsurface water flow depended on the position around the geomorphological structures and on the river level. The methodology presented in this paper features great potential for characterising the spatial patterns and temporal dynamics of complex subsurface flow geometries by using measured temperature time series in vertical profiles. (C) 2016 Elsevier B.V. All rights reserved.
KW  - Temperature time series
KW  - Amplitude ratio
KW  - River-groundwater exchange
KW  - Hyporheic zone
KW  - In-stream geomorphological structures
KW  - River restoration
Y1  - 2016
U6  - https://doi.org/10.1016/j.jhydrol.2016.05.012
SN  - 0022-1694
SN  - 1879-2707
VL  - 539
SP  - 74
EP  - 87
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - BOOK
A1  - Rana, Kaushik
A1  - Mohapatra, Durga Prasad
A1  - Sidorova, Julia
A1  - Lundberg, Lars
A1  - Sköld, Lars
A1  - Lopes Grim, Luís Fernando
A1  - Sampaio Gradvohl, André Leon
A1  - Cremerius, Jonas
A1  - Siegert, Simon
A1  - Weltzien, Anton von
A1  - Baldi, Annika
A1  - Klessascheck, Finn
A1  - Kalancha, Svitlana
A1  - Lichtenstein, Tom
A1  - Shaabani, Nuhad
A1  - Meinel, Christoph
A1  - Friedrich, Tobias
A1  - Lenzner, Pascal
A1  - Schumann, David
A1  - Wiese, Ingmar
A1  - Sarna, Nicole
A1  - Wiese, Lena
A1  - Tashkandi, Araek Sami
A1  - van der Walt, Estée
A1  - Eloff, Jan H. P.
A1  - Schmidt, Christopher
A1  - Hügle, Johannes
A1  - Horschig, Siegfried
A1  - Uflacker, Matthias
A1  - Najafi, Pejman
A1  - Sapegin, Andrey
A1  - Cheng, Feng
A1  - Stojanovic, Dragan
A1  - Stojnev Ilić, Aleksandra
A1  - Djordjevic, Igor
A1  - Stojanovic, Natalija
A1  - Predic, Bratislav
A1  - González-Jiménez, Mario
A1  - de Lara, Juan
A1  - Mischkewitz, Sven
A1  - Kainz, Bernhard
A1  - van Hoorn, André
A1  - Ferme, Vincenzo
A1  - Schulz, Henning
A1  - Knigge, Marlene
A1  - Hecht, Sonja
A1  - Prifti, Loina
A1  - Krcmar, Helmut
A1  - Fabian, Benjamin
A1  - Ermakova, Tatiana
A1  - Kelkel, Stefan
A1  - Baumann, Annika
A1  - Morgenstern, Laura
A1  - Plauth, Max
A1  - Eberhard, Felix
A1  - Wolff, Felix
A1  - Polze, Andreas
A1  - Cech, Tim
A1  - Danz, Noel
A1  - Noack, Nele Sina
A1  - Pirl, Lukas
A1  - Beilharz, Jossekin Jakob
A1  - De Oliveira, Roberto C. L.
A1  - Soares, Fábio Mendes
A1  - Juiz, Carlos
A1  - Bermejo, Belen
A1  - Mühle, Alexander
A1  - Grüner, Andreas
A1  - Saxena, Vageesh
A1  - Gayvoronskaya, Tatiana
A1  - Weyand, Christopher
A1  - Krause, Mirko
A1  - Frank, Markus
A1  - Bischoff, Sebastian
A1  - Behrens, Freya
A1  - Rückin, Julius
A1  - Ziegler, Adrian
A1  - Vogel, Thomas
A1  - Tran, Chinh
A1  - Moser, Irene
A1  - Grunske, Lars
A1  - Szárnyas, Gábor
A1  - Marton, József
A1  - Maginecz, János
A1  - Varró, Dániel
A1  - Antal, János Benjamin
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Beins, Karsten
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Rödszus, Kurt
ED  - Müller, Jürgen
T1  - HPI Future SOC Lab – Proceedings 2018
N2  - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
  The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
  This technical report presents results of research projects executed in 2018. Selected projects have presented their results on April 17th and November 14th 2017 at the Future SOC Lab Day events.
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
  Am Lab wird interessierten Wissenschaftler:innen eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen Systeme, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler:innen in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
  In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2018 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 17. April und 14. November 2018 im Rahmen des Future SOC Lab Tags vor.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 151 
KW  - Future SOC Lab
KW  - research projects
KW  - multicore architectures
KW  - in-memory technology
KW  - cloud computing
KW  - machine learning
KW  - artifical intelligence
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-563712
SN  - 978-3-86956-547-7
SN  - 1613-5652
SN  - 2191-1665
IS  - 151
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Kamm, Birgit
A1  - Kamm, Michael
A1  - Schmidt, Matthias
A1  - Starke, Ines
A1  - Kleinpeter, Erich
T1  - Chemical and biochemical generation of carbohydrates from lignocellulose-feedstock (Lupinus nootkatensis) : quantification of glucose
N2  - Different chemical and enzymatic methods were applied for the hydrolysis of main stems from Lupinus nootkatensis (harvest November 2002). The whole process (all steps) is based on the lignocellulose-feedstock biorefinery regime. The acid hydrolysis of L. was performed with concentrated hydrochloric acid; advantages in this process are exothermic hydrolysis and the possibility of acid recovery. Enzymatic hydrolysis achieved high yields of fermentable carbohydrates (regarding to input cellulose) with high selectivity. However, this way requires the generation of cellulose from L. by chemical pulping. Monosaccharide derivatives thus obtained were identified by their GC retention times and the corresponding MS fragmentation. Hexamethyldisilazane was used as derivatization reagent to prepare the trimethylsilyl derivatives of the carbohydrates and of the degradations products of cellulose from the different fractions. The glucose content was quantified by GC peak integration with respect to an internal standard.
Y1  - 2006
UR  - http://www.sciencedirect.com/science/journal/00456535
U6  - https://doi.org/10.1016/j.chemosphere.2005.03.073
SN  - 0045-6535
ER  - 
TY  - BOOK
A1  - Kuban, Robert
A1  - Rotta, Randolf
A1  - Nolte, Jörg
A1  - Chromik, Jonas
A1  - Beilharz, Jossekin Jakob
A1  - Pirl, Lukas
A1  - Friedrich, Tobias
A1  - Lenzner, Pascal
A1  - Weyand, Christopher
A1  - Juiz, Carlos
A1  - Bermejo, Belen
A1  - Sauer, Joao
A1  - Coelh, Leandro dos Santos
A1  - Najafi, Pejman
A1  - Pünter, Wenzel
A1  - Cheng, Feng
A1  - Meinel, Christoph
A1  - Sidorova, Julia
A1  - Lundberg, Lars
A1  - Vogel, Thomas
A1  - Tran, Chinh
A1  - Moser, Irene
A1  - Grunske, Lars
A1  - Elsaid, Mohamed Esameldin Mohamed
A1  - Abbas, Hazem M.
A1  - Rula, Anisa
A1  - Sejdiu, Gezim
A1  - Maurino, Andrea
A1  - Schmidt, Christopher
A1  - Hügle, Johannes
A1  - Uflacker, Matthias
A1  - Nozza, Debora
A1  - Messina, Enza
A1  - Hoorn, André van
A1  - Frank, Markus
A1  - Schulz, Henning
A1  - Alhosseini Almodarresi Yasin, Seyed Ali
A1  - Nowicki, Marek
A1  - Muite, Benson K.
A1  - Boysan, Mehmet Can
A1  - Bianchi, Federico
A1  - Cremaschi, Marco
A1  - Moussa, Rim
A1  - Abdel-Karim, Benjamin M.
A1  - Pfeuffer, Nicolas
A1  - Hinz, Oliver
A1  - Plauth, Max
A1  - Polze, Andreas
A1  - Huo, Da
A1  - Melo, Gerard de
A1  - Mendes Soares, Fábio
A1  - Oliveira, Roberto Célio Limão de
A1  - Benson, Lawrence
A1  - Paul, Fabian
A1  - Werling, Christian
A1  - Windheuser, Fabian
A1  - Stojanovic, Dragan
A1  - Djordjevic, Igor
A1  - Stojanovic, Natalija
A1  - Stojnev Ilic, Aleksandra
A1  - Weidmann, Vera
A1  - Lowitzki, Leon
A1  - Wagner, Markus
A1  - Ifa, Abdessatar Ben
A1  - Arlos, Patrik
A1  - Megia, Ana
A1  - Vendrell, Joan
A1  - Pfitzner, Bjarne
A1  - Redondo, Alberto
A1  - Ríos Insua, David
A1  - Albert, Justin Amadeus
A1  - Zhou, Lin
A1  - Arnrich, Bert
A1  - Szabó, Ildikó
A1  - Fodor, Szabina
A1  - Ternai, Katalin
A1  - Bhowmik, Rajarshi
A1  - Campero Durand, Gabriel
A1  - Shevchenko, Pavlo
A1  - Malysheva, Milena
A1  - Prymak, Ivan
A1  - Saake, Gunter
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Beins, Karsten
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Rödszus, Kurt
ED  - Müller, Jürgen
T1  - HPI Future SOC Lab – Proceedings 2019
N2  - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
  The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
  This technical report presents results of research projects executed in 2019. Selected projects have presented their results on April 9th and November 12th 2019 at the Future SOC Lab Day events.
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
  Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
  In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2019 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 09. April und 12. November 2019 im Rahmen des Future SOC Lab Tags vor.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 158 
KW  - Future SOC Lab
KW  - research projects
KW  - multicore architectures
KW  - in-memory technology
KW  - cloud computing
KW  - machine learning
KW  - artifical intelligence
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-597915
SN  - 978-3-86956-564-4
SN  - 1613-5652
SN  - 2191-1665
IS  - 158
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Schrön, Martin
A1  - Köhli, Markus
A1  - Scheiffele, Lena
A1  - Iwema, Joost
A1  - Bogena, Heye R.
A1  - Lv, Ling
A1  - Martini, Edoardo
A1  - Baroni, Gabriele
A1  - Rosolem, Rafael
A1  - Weimar, Jannis
A1  - Mai, Juliane
A1  - Cuntz, Matthias
A1  - Rebmann, Corinna
A1  - Oswald, Sascha
A1  - Dietrich, Peter
A1  - Schmidt, Ulrich
A1  - Zacharias, Steffen
T1  - Improving calibration and validation of cosmic-ray neutron sensors in the light of spatial sensitivity
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - In the last few years the method of cosmic-ray neutron sensing (CRNS) has gained popularity among hydrologists, physicists, and land-surface modelers. The sensor provides continuous soil moisture data, averaged over several hectares and tens of decimeters in depth. However, the signal still may contain unidentified features of hydrological processes, and many calibration datasets are often required in order to find reliable relations between neutron intensity and water dynamics. Recent insights into environmental neutrons accurately described the spatial sensitivity of the sensor and thus allowed one to quantify the contribution of individual sample locations to the CRNS signal. Consequently, data points of calibration and validation datasets are suggested to be averaged using a more physically based weighting approach. In this work, a revised sensitivity function is used to calculate weighted averages of point data. The function is different from the simple exponential convention by the extraordinary sensitivity to the first few meters around the probe, and by dependencies on air pressure, air humidity, soil moisture, and vegetation. The approach is extensively tested at six distinct monitoring sites: two sites with multiple calibration datasets and four sites with continuous time series datasets. In all cases, the revised averaging method improved the performance of the CRNS products. The revised approach further helped to reveal hidden hydrological processes which otherwise remained unexplained in the data or were lost in the process of overcalibration. The presented weighting approach increases the overall accuracy of CRNS products and will have an impact on all their applications in agriculture, hydrology, and modeling.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 636 
KW  - forested headwater catchment
KW  - moisture observing system
KW  - soil-water content
KW  - parameterization methods
KW  - scale
KW  - field
KW  - dynamics
KW  - observatories
KW  - networks
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-419134
IS  - 636
SP  - 5009
EP  - 5030
ER  - 
TY  - JOUR
A1  - Schrön, Martin
A1  - Köhli, Markus
A1  - Scheiffele, Lena
A1  - Iwema, Joost
A1  - Bogena, Heye R.
A1  - Lv, Ling
A1  - Martini, Edoardo
A1  - Baroni, Gabriele
A1  - Rosolem, Rafael
A1  - Weimar, Jannis
A1  - Mai, Juliane
A1  - Cuntz, Matthias
A1  - Rebmann, Corinna
A1  - Oswald, Sascha
A1  - Dietrich, Peter
A1  - Schmidt, Ulrich
A1  - Zacharias, Steffen
T1  - Improving calibration and validation of cosmic-ray neutron sensors in the light of spatial sensitivity
JF  - Hydrology and earth system sciences : HESS
N2  - In the last few years the method of cosmic-ray neutron sensing (CRNS) has gained popularity among hydrologists, physicists, and land-surface modelers. The sensor provides continuous soil moisture data, averaged over several hectares and tens of decimeters in depth. However, the signal still may contain unidentified features of hydrological processes, and many calibration datasets are often required in order to find reliable relations between neutron intensity and water dynamics. Recent insights into environmental neutrons accurately described the spatial sensitivity of the sensor and thus allowed one to quantify the contribution of individual sample locations to the CRNS signal. Consequently, data points of calibration and validation datasets are suggested to be averaged using a more physically based weighting approach. In this work, a revised sensitivity function is used to calculate weighted averages of point data. The function is different from the simple exponential convention by the extraordinary sensitivity to the first few meters around the probe, and by dependencies on air pressure, air humidity, soil moisture, and vegetation. The approach is extensively tested at six distinct monitoring sites: two sites with multiple calibration datasets and four sites with continuous time series datasets. In all cases, the revised averaging method improved the performance of the CRNS products. The revised approach further helped to reveal hidden hydrological processes which otherwise remained unexplained in the data or were lost in the process of overcalibration. The presented weighting approach increases the overall accuracy of CRNS products and will have an impact on all their applications in agriculture, hydrology, and modeling.
Y1  - 2017
U6  - https://doi.org/10.5194/hess-21-5009-2017
SN  - 1027-5606
SN  - 1607-7938
VL  - 21
SP  - 5009
EP  - 5030
PB  - Copernicus
CY  - Göttingen
ER  -