TY - JOUR A1 - Wuttke, Matthias A1 - Li, Yong A1 - Li, Man A1 - Sieber, Karsten B. A1 - Feitosa, Mary F. A1 - Gorski, Mathias A1 - Tin, Adrienne A1 - Wang, Lihua A1 - Chu, Audrey Y. A1 - Hoppmann, Anselm A1 - Kirsten, Holger A1 - Giri, Ayush A1 - Chai, Jin-Fang A1 - Sveinbjornsson, Gardar A1 - Tayo, Bamidele O. A1 - Nutile, Teresa A1 - Fuchsberger, Christian A1 - Marten, Jonathan A1 - Cocca, Massimiliano A1 - Ghasemi, Sahar A1 - Xu, Yizhe A1 - Horn, Katrin A1 - Noce, Damia A1 - Van der Most, Peter J. A1 - Sedaghat, Sanaz A1 - Yu, Zhi A1 - Akiyama, Masato A1 - Afaq, Saima A1 - Ahluwalia, Tarunveer Singh A1 - Almgren, Peter A1 - Amin, Najaf A1 - Arnlov, Johan A1 - Bakker, Stephan J. L. A1 - Bansal, Nisha A1 - Baptista, Daniela A1 - Bergmann, Sven A1 - Biggs, Mary L. A1 - Biino, Ginevra A1 - Boehnke, Michael A1 - Boerwinkle, Eric A1 - Boissel, Mathilde A1 - Böttinger, Erwin A1 - Boutin, Thibaud S. A1 - Brenner, Hermann A1 - Brumat, Marco A1 - Burkhardt, Ralph A1 - Butterworth, Adam S. A1 - Campana, Eric A1 - Campbell, Archie A1 - Campbell, Harry A1 - Canouil, Mickael A1 - Carroll, Robert J. A1 - Catamo, Eulalia A1 - Chambers, John C. A1 - Chee, Miao-Ling A1 - Chee, Miao-Li A1 - Chen, Xu A1 - Cheng, Ching-Yu A1 - Cheng, Yurong A1 - Christensen, Kaare A1 - Cifkova, Renata A1 - Ciullo, Marina A1 - Concas, Maria Pina A1 - Cook, James P. A1 - Coresh, Josef A1 - Corre, Tanguy A1 - Sala, Cinzia Felicita A1 - Cusi, Daniele A1 - Danesh, John A1 - Daw, E. Warwick A1 - De Borst, Martin H. A1 - De Grandi, Alessandro A1 - De Mutsert, Renee A1 - De Vries, Aiko P. J. A1 - Degenhardt, Frauke A1 - Delgado, Graciela A1 - Demirkan, Ayse A1 - Di Angelantonio, Emanuele A1 - Dittrich, Katalin A1 - Divers, Jasmin A1 - Dorajoo, Rajkumar A1 - Eckardt, Kai-Uwe A1 - Ehret, Georg A1 - Elliott, Paul A1 - Endlich, Karlhans A1 - Evans, Michele K. A1 - Felix, Janine F. A1 - Foo, Valencia Hui Xian A1 - Franco, Oscar H. A1 - Franke, Andre A1 - Freedman, Barry I. A1 - Freitag-Wolf, Sandra A1 - Friedlander, Yechiel A1 - Froguel, Philippe A1 - Gansevoort, Ron T. A1 - Gao, He A1 - Gasparini, Paolo A1 - Gaziano, J. Michael A1 - Giedraitis, Vilmantas A1 - Gieger, Christian A1 - Girotto, Giorgia A1 - Giulianini, Franco A1 - Gogele, Martin A1 - Gordon, Scott D. A1 - Gudbjartsson, Daniel F. A1 - Gudnason, Vilmundur A1 - Haller, Toomas A1 - Hamet, Pavel A1 - Harris, Tamara B. A1 - Hartman, Catharina A. A1 - Hayward, Caroline A1 - Hellwege, Jacklyn N. A1 - Heng, Chew-Kiat A1 - Hicks, Andrew A. A1 - Hofer, Edith A1 - Huang, Wei A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Indridason, Olafur S. A1 - Ingelsson, Erik A1 - Ising, Marcus A1 - Jaddoe, Vincent W. V. A1 - Jakobsdottir, Johanna A1 - Jonas, Jost B. A1 - Joshi, Peter K. A1 - Josyula, Navya Shilpa A1 - Jung, Bettina A1 - Kahonen, Mika A1 - Kamatani, Yoichiro A1 - Kammerer, Candace M. A1 - Kanai, Masahiro A1 - Kastarinen, Mika A1 - Kerr, Shona M. A1 - Khor, Chiea-Chuen A1 - Kiess, Wieland A1 - Kleber, Marcus E. A1 - Koenig, Wolfgang A1 - Kooner, Jaspal S. A1 - Korner, Antje A1 - Kovacs, Peter A1 - Kraja, Aldi T. A1 - Krajcoviechova, Alena A1 - Kramer, Holly A1 - Kramer, Bernhard K. A1 - Kronenberg, Florian A1 - Kubo, Michiaki A1 - Kuhnel, Brigitte A1 - Kuokkanen, Mikko A1 - Kuusisto, Johanna A1 - La Bianca, Martina A1 - Laakso, Markku A1 - Lange, Leslie A. A1 - Langefeld, Carl D. A1 - Lee, Jeannette Jen-Mai A1 - Lehne, Benjamin A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Lim, Su-Chi A1 - Lind, Lars A1 - Lindgren, Cecilia M. A1 - Liu, Jun A1 - Liu, Jianjun A1 - Loeffler, Markus A1 - Loos, Ruth J. F. A1 - Lucae, Susanne A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Magi, Reedik A1 - Magnusson, Patrik K. E. A1 - Mahajan, Anubha A1 - Martin, Nicholas G. A1 - Martins, Jade A1 - Marz, Winfried A1 - Mascalzoni, Deborah A1 - Matsuda, Koichi A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Metspalu, Andres A1 - Mikaelsdottir, Evgenia K. A1 - Milaneschi, Yuri A1 - Miliku, Kozeta A1 - Mishra, Pashupati P. A1 - Program, V. A. Million Veteran A1 - Mohlke, Karen L. A1 - Mononen, Nina A1 - Montgomery, Grant W. A1 - Mook-Kanamori, Dennis O. A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nalls, Mike A. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - Noordam, Raymond A1 - Olafsson, Isleifur A1 - Oldehinkel, Albertine J. A1 - Orho-Melander, Marju A1 - Ouwehand, Willem H. A1 - Padmanabhan, Sandosh A1 - Palmer, Nicholette D. A1 - Palsson, Runolfur A1 - Penninx, Brenda W. J. H. A1 - Perls, Thomas A1 - Perola, Markus A1 - Pirastu, Mario A1 - Pirastu, Nicola A1 - Pistis, Giorgio A1 - Podgornaia, Anna I. A1 - Polasek, Ozren A1 - Ponte, Belen A1 - Porteous, David J. A1 - Poulain, Tanja A1 - Pramstaller, Peter P. A1 - Preuss, Michael H. A1 - Prins, Bram P. A1 - Province, Michael A. A1 - Rabelink, Ton J. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Reilly, Dermot F. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Ridker, Paul M. A1 - Rivadeneira, Fernando A1 - Rizzi, Federica A1 - Roberts, David J. A1 - Robino, Antonietta A1 - Rossing, Peter A1 - Rudan, Igor A1 - Rueedi, Rico A1 - Ruggiero, Daniela A1 - Ryan, Kathleen A. A1 - Saba, Yasaman A1 - Sabanayagam, Charumathi A1 - Salomaa, Veikko A1 - Salvi, Erika A1 - Saum, Kai-Uwe A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Ben Schottker, A1 - Schulz, Christina-Alexandra A1 - Schupf, Nicole A1 - Shaffer, Christian M. A1 - Shi, Yuan A1 - Smith, Albert V. A1 - Smith, Blair H. A1 - Soranzo, Nicole A1 - Spracklen, Cassandra N. A1 - Strauch, Konstantin A1 - Stringham, Heather M. A1 - Stumvoll, Michael A1 - Svensson, Per O. A1 - Szymczak, Silke A1 - Tai, E-Shyong A1 - Tajuddin, Salman M. A1 - Tan, Nicholas Y. Q. A1 - Taylor, Kent D. A1 - Teren, Andrej A1 - Tham, Yih-Chung A1 - Thiery, Joachim A1 - Thio, Chris H. L. A1 - Thomsen, Hauke A1 - Thorleifsson, Gudmar A1 - Toniolo, Daniela A1 - Tonjes, Anke A1 - Tremblay, Johanne A1 - Tzoulaki, Ioanna A1 - Uitterlinden, Andre G. A1 - Vaccargiu, Simona A1 - Van Dam, Rob M. A1 - Van der Harst, Pim A1 - Van Duijn, Cornelia M. A1 - Edward, Digna R. Velez A1 - Verweij, Niek A1 - Vogelezang, Suzanne A1 - Volker, Uwe A1 - Vollenweider, Peter A1 - Waeber, Gerard A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Wang, Ya Xing A1 - Wang, Chaolong A1 - Waterworth, Dawn M. A1 - Bin Wei, Wen A1 - White, Harvey A1 - Whitfield, John B. A1 - Wild, Sarah H. A1 - Wilson, James F. A1 - Wojczynski, Mary K. A1 - Wong, Charlene A1 - Wong, Tien-Yin A1 - Xu, Liang A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Weihua A1 - Zonderman, Alan B. A1 - Rotter, Jerome I. A1 - Bochud, Murielle A1 - Psaty, Bruce M. A1 - Vitart, Veronique A1 - Wilson, James G. A1 - Dehghan, Abbas A1 - Parsa, Afshin A1 - Chasman, Daniel I. A1 - Ho, Kevin A1 - Morris, Andrew P. A1 - Devuyst, Olivier A1 - Akilesh, Shreeram A1 - Pendergrass, Sarah A. A1 - Sim, Xueling A1 - Boger, Carsten A. A1 - Okada, Yukinori A1 - Edwards, Todd L. A1 - Snieder, Harold A1 - Stefansson, Kari A1 - Hung, Adriana M. A1 - Heid, Iris M. A1 - Scholz, Markus A1 - Teumer, Alexander A1 - Kottgen, Anna A1 - Pattaro, Cristian T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals JF - Nature genetics N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research. Y1 - 2019 U6 - https://doi.org/10.1038/s41588-019-0407-x SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 6 SP - 957 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Taal, H. Rob A1 - St Pourcain, Beate A1 - Thiering, Elisabeth A1 - Das, Shikta A1 - Mook-Kanamori, Dennis O. A1 - Warrington, Nicole M. A1 - Kaakinen, Marika A1 - Kreiner-Moller, Eskil A1 - Bradfield, Jonathan P. A1 - Freathy, Rachel M. A1 - Geller, Frank A1 - Guxens, Monica A1 - Cousminer, Diana L. A1 - Kerkhof, Marjan A1 - Timpson, Nicholas J. A1 - Ikram, M. Arfan A1 - Beilin, Lawrence J. A1 - Bonnelykke, Klaus A1 - Buxton, Jessica L. A1 - Charoen, Pimphen A1 - Chawes, Bo Lund Krogsgaard A1 - Eriksson, Johan A1 - Evans, David M. A1 - Hofman, Albert A1 - Kemp, John P. A1 - Kim, Cecilia E. A1 - Klopp, Norman A1 - Lahti, Jari A1 - Lye, Stephen J. A1 - McMahon, George A1 - Mentch, Frank D. A1 - Mueller-Nurasyid, Martina A1 - O'Reilly, Paul F. A1 - Prokopenko, Inga A1 - Rivadeneira, Fernando A1 - Steegers, Eric A. P. A1 - Sunyer, Jordi A1 - Tiesler, Carla A1 - Yaghootkar, Hanieh A1 - Breteler, Monique M. B. A1 - Debette, Stephanie A1 - Fornage, Myriam A1 - Gudnason, Vilmundur A1 - Launer, Lenore J. A1 - van der Lugt, Aad A1 - Mosley, Thomas H. A1 - Seshadri, Sudha A1 - Smith, Albert V. A1 - Vernooij, Meike W. A1 - Blakemore, Alexandra I. F. A1 - Chiavacci, Rosetta M. A1 - Feenstra, Bjarke A1 - Fernandez-Banet, Julio A1 - Grant, Struan F. A. A1 - Hartikainen, Anna-Liisa A1 - van der Heijden, Albert J. A1 - Iniguez, Carmen A1 - Lathrop, Mark A1 - McArdle, Wendy L. A1 - Molgaard, Anne A1 - Newnham, John P. A1 - Palmer, Lyle J. A1 - Palotie, Aarno A1 - Pouta, Annneli A1 - Ring, Susan M. A1 - Sovio, Ulla A1 - Standl, Marie A1 - Uitterlinden, Andre G. A1 - Wichmann, H-Erich A1 - Vissing, Nadja Hawwa A1 - DeCarli, Charles A1 - van Duijn, Cornelia M. A1 - McCarthy, Mark I. A1 - Koppelman, Gerard H. A1 - Estivill, Xavier A1 - Hattersley, Andrew T. A1 - Melbye, Mads A1 - Bisgaard, Hans A1 - Pennell, Craig E. A1 - Widen, Elisabeth A1 - Hakonarson, Hakon A1 - Smith, George Davey A1 - Heinrich, Joachim A1 - Jarvelin, Marjo-Riitta A1 - Jaddoe, Vincent W. V. A1 - Adair, Linda S. A1 - Ang, Wei A1 - Atalay, Mustafa A1 - van Beijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Bradfield, Jonathan P. A1 - Charoen, Pimphen A1 - Coin, Lachlan A1 - Cousminer, Diana L. A1 - Das, Shikta A1 - Davis, Oliver S. P. A1 - Elliott, Paul A1 - Evans, David M. A1 - Feenstra, Bjarke A1 - Flexeder, Claudia A1 - Frayling, Tim A1 - Freathy, Rachel M. A1 - Gaillard, Romy A1 - Geller, Frank A1 - Groen-Blokhuis, Maria A1 - Goh, Liang-Kee A1 - Guxens, Monica A1 - Haworth, Claire M. A. A1 - Hadley, Dexter A1 - Hebebrand, Johannes A1 - Hinney, Anke A1 - Hirschhorn, Joel N. A1 - Holloway, John W. A1 - Holst, Claus A1 - Hottenga, Jouke Jan A1 - Horikoshi, Momoko A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Iniguez, Carmen A1 - Kaakinen, Marika A1 - Kilpelainen, Tuomas O. A1 - Kirin, Mirna A1 - Kowgier, Matthew A1 - Lakka, Hanna-Maaria A1 - Lange, Leslie A. A1 - Lawlor, Debbie A. A1 - Lehtimaki, Terho A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Lindi, Virpi A1 - Maggi, Reedik A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Mook-Kanamori, Dennis O. A1 - Murray, Jeffrey C. A1 - Nivard, Michel A1 - Nohr, Ellen Aagaard A1 - Ntalla, Ioanna A1 - Oken, Emily A1 - O'Reilly, Paul F. A1 - Palmer, Lyle J. A1 - Panoutsopoulou, Kalliope A1 - Pararajasingham, Jennifer A1 - Prokopenko, Inga A1 - Rodriguez, Alina A1 - Salem, Rany M. A1 - Sebert, Sylvain A1 - Siitonen, Niina A1 - Sovio, Ulla A1 - St Pourcain, Beate A1 - Strachan, David P. A1 - Sunyer, Jordi A1 - Taal, H. Rob A1 - Teo, Yik-Ying A1 - Thiering, Elisabeth A1 - Tiesler, Carla A1 - Uitterlinden, Andre G. A1 - Valcarcel, Beatriz A1 - Warrington, Nicole M. A1 - White, Scott A1 - Willemsen, Gonneke A1 - Yaghootkar, Hanieh A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Cooper, Cyrus A1 - Estivill, Xavier A1 - Gillman, Matthew A1 - Grant, Struan F. A. A1 - Hakonarson, Hakon A1 - Hattersley, Andrew T. A1 - Heinrich, Joachim A1 - Hocher, Berthold A1 - Jaddoe, Vincent W. V. A1 - Jarvelin, Marjo-Riitta A1 - Lakka, Timo A. A1 - McCarthy, Mark I. A1 - Melbye, Mads A1 - Mohlke, Karen L. A1 - Dedoussis, George V. A1 - Ong, Ken K. A1 - Pearson, Ewan R. A1 - Pennell, Craig E. A1 - Price, Thomas S. A1 - Power, Chris A1 - Raitakari, Olli T. A1 - Saw, Seang-Mei A1 - Scherag, Andre A1 - Simell, Olli A1 - Sorensen, Thorkild I. A. A1 - Timpson, Nicholas J. A1 - Widen, Elisabeth A1 - Wilson, James F. A1 - Ang, Wei A1 - van Beijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Bradfield, Jonathan P. A1 - Charoen, Pimphen A1 - Coin, Lachlan A1 - Cousminer, Diana L. A1 - Das, Shikta A1 - Elliott, Paul A1 - Evans, David M. A1 - Frayling, Tim A1 - Freathy, Rachel M. A1 - Gaillard, Romy A1 - Groen-Blokhuis, Maria A1 - Guxens, Monica A1 - Hadley, Dexter A1 - Hottenga, Jouke Jan A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Kaakinen, Marika A1 - Kowgier, Matthew A1 - Lawlor, Debbie A. A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Mook-Kanamori, Dennis O. A1 - Nivard, Michel A1 - O'Reilly, Paul F. A1 - Palmer, Lyle J. A1 - Prokopenko, Inga A1 - Rodriguez, Alina A1 - Sebert, Sylvain A1 - Sovio, Ulla A1 - St Pourcain, Beate A1 - Standl, Marie A1 - Strachan, David P. A1 - Sunyer, Jordi A1 - Taal, H. Rob A1 - Thiering, Elisabeth A1 - Tiesler, Carla A1 - Uitterlinden, Andre G. A1 - Valcarcel, Beatriz A1 - Warrington, Nicole M. A1 - White, Scott A1 - Willemsen, Gonneke A1 - Yaghootkar, Hanieh A1 - Boomsma, Dorret I. A1 - Estivill, Xavier A1 - Grant, Struan F. A. A1 - Hakonarson, Hakon A1 - Hattersley, Andrew T. A1 - Heinrich, Joachim A1 - Jaddoe, Vincent W. V. A1 - Jarvelin, Marjo-Riitta A1 - McCarthy, Mark I. A1 - Pennell, Craig E. A1 - Power, Chris A1 - Timpson, Nicholas J. A1 - Widen, Elisabeth A1 - Ikram, M. Arfan A1 - Fornage, Myriam A1 - Smith, Albert V. A1 - Seshadri, Sudha A1 - Schmidt, Reinhold A1 - Debette, Stephanie A1 - Vrooman, Henri A. A1 - Sigurdsson, Sigurdur A1 - Ropele, Stefan A1 - Coker, Laura H. A1 - Longstreth, W. T. A1 - Niessen, Wiro J. A1 - DeStefano, Anita L. A1 - Beiser, Alexa A1 - Zijdenbos, Alex P. A1 - Struchalin, Maksim A1 - Jack, Clifford R. A1 - Nalls, Mike A. A1 - Au, Rhoda A1 - Hofman, Albert A1 - Gudnason, Haukur A1 - van der Lugt, Aad A1 - Harris, Tamara B. A1 - Meeks, William M. A1 - Vernooij, Meike W. A1 - van Buchem, Mark A. A1 - Catellier, Diane A1 - Gudnason, Vilmundur A1 - Windham, B. Gwen A1 - Wolf, Philip A. A1 - van Duijn, Cornelia M. A1 - Mosley, Thomas H. A1 - Schmidt, Helena A1 - Launer, Lenore J. A1 - Breteler, Monique M. B. A1 - DeCarli, Charles T1 - Common variants at 12q15 and 12q24 are associated with infant head circumference JF - Nature genetics N2 - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life. Y1 - 2012 U6 - https://doi.org/10.1038/ng.2238 SN - 1061-4036 VL - 44 IS - 5 SP - 532 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Ikram, M. Arfan A1 - Fornage, Myriam A1 - Smith, Albert V. A1 - Seshadri, Sudha A1 - Schmidt, Reinhold A1 - Debette, Stephanie A1 - Vrooman, Henri A. A1 - Sigurdsson, Sigurdur A1 - Ropele, Stefan A1 - Taal, H. Rob A1 - Mook-Kanamori, Dennis O. A1 - Coker, Laura H. A1 - Longstreth, W. T. A1 - Niessen, Wiro J. A1 - DeStefano, Anita L. A1 - Beiser, Alexa A1 - Zijdenbos, Alex P. A1 - Struchalin, Maksim A1 - Jack, Clifford R. A1 - Rivadeneira, Fernando A1 - Uitterlinden, Andre G. A1 - Knopman, David S. A1 - Hartikainen, Anna-Liisa A1 - Pennell, Craig E. A1 - Thiering, Elisabeth A1 - Steegers, Eric A. P. A1 - Hakonarson, Hakon A1 - Heinrich, Joachim A1 - Palmer, Lyle J. A1 - Jarvelin, Marjo-Riitta A1 - McCarthy, Mark I. A1 - Grant, Struan F. A. A1 - St Pourcain, Beate A1 - Timpson, Nicholas J. A1 - Smith, George Davey A1 - Sovio, Ulla A1 - Nalls, Mike A. A1 - Au, Rhoda A1 - Hofman, Albert A1 - Gudnason, Haukur A1 - van der Lugt, Aad A1 - Harris, Tamara B. A1 - Meeks, William M. A1 - Vernooij, Meike W. A1 - van Buchem, Mark A. A1 - Catellier, Diane A1 - Jaddoe, Vincent W. V. A1 - Gudnason, Vilmundur A1 - Windham, B. Gwen A1 - Wolf, Philip A. A1 - van Duijn, Cornelia M. A1 - Mosley, Thomas H. A1 - Schmidt, Helena A1 - Launer, Lenore J. A1 - Breteler, Monique M. B. A1 - DeCarli, Charles A1 - Adair, Linda S. A1 - Ang, Wei A1 - Atalay, Mustafa A1 - vanBeijsterveldt, Toos A1 - Bergen, Nienke A1 - Benke, Kelly A1 - Berry, Diane J. A1 - Coin, Lachlan A1 - Davis, Oliver S. P. A1 - Elliott, Paul A1 - Flexeder, Claudia A1 - Frayling, Tim A1 - Gaillard, Romy A1 - Groen-Blokhuis, Maria A1 - Goh, Liang-Kee A1 - Haworth, Claire M. A. A1 - Hadley, Dexter A1 - Hebebrand, Johannes A1 - Hinney, Anke A1 - Hirschhorn, Joel N. A1 - Holloway, John W. A1 - Holst, Claus A1 - Hottenga, Jouke Jan A1 - Horikoshi, Momoko A1 - Huikari, Ville A1 - Hypponen, Elina A1 - Kilpelainen, Tuomas O. A1 - Kirin, Mirna A1 - Kowgier, Matthew A1 - Lakka, Hanna-Maaria A1 - Lange, Leslie A. A1 - Lawlor, Debbie A. A1 - Lehtimaki, Terho A1 - Lewin, Alex A1 - Lindgren, Cecilia A1 - Lindi, Virpi A1 - Maggi, Reedik A1 - Marsh, Julie A1 - Middeldorp, Christel A1 - Millwood, Iona A1 - Murray, Jeffrey C. A1 - Nivard, Michel A1 - Nohr, Ellen Aagaard A1 - Ntalla, Ioanna A1 - Oken, Emily A1 - Panoutsopoulou, Kalliope A1 - Pararajasingham, Jennifer A1 - Rodriguez, Alina A1 - Salem, Rany M. A1 - Sebert, Sylvain A1 - Siitonen, Niina A1 - Strachan, David P. A1 - Teo, Yik-Ying A1 - Valcarcel, Beatriz A1 - Willemsen, Gonneke A1 - Zeggini, Eleftheria A1 - Boomsma, Dorret I. A1 - Cooper, Cyrus A1 - Gillman, Matthew A1 - Hocher, Berthold A1 - Lakka, Timo A. A1 - Mohlke, Karen L. A1 - Dedoussis, George V. A1 - Ong, Ken K. A1 - Pearson, Ewan R. A1 - Price, Thomas S. A1 - Power, Chris A1 - Raitakari, Olli T. A1 - Saw, Seang-Mei A1 - Scherag, Andre A1 - Simell, Olli A1 - Sorensen, Thorkild I. A. A1 - Wilson, James F. T1 - Common variants at 6q22 and 17q21 are associated with intracranial volume JF - Nature genetics N2 - During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size. 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A1 - Stringhetti, L. A1 - Suarez, A. A1 - Suchenek, M. A1 - Sugawara, R. A1 - Sulanke, K. -H. A1 - Sun, S. A1 - Supanitsky, A. D. A1 - Suric, T. A1 - Sutcliffe, P. A1 - Sykes, J. A1 - Szanecki, M. A1 - Szepieniec, T. A1 - Szostek, A. A1 - Tagliaferri, G. A1 - Tajima, H. A1 - Takahashi, H. A1 - Takahashi, K. A1 - Takalo, L. A1 - Takami, H. A1 - Talbot, C. A1 - Tammi, J. A1 - Tanaka, M. A1 - Tanaka, S. A1 - Tasan, J. A1 - Tavani, M. A1 - Tavernet, J. -P. A1 - Tejedor, L. A. A1 - Telezhinsky, Igor O. A1 - Temnikov, P. A1 - Tenzer, C. A1 - Terada, Y. A1 - Terrier, R. A1 - Teshima, M. A1 - Testa, V. A1 - Tezier, D. A1 - Thuermann, D. A1 - Tibaldo, L. A1 - Tibolla, O. A1 - Tiengo, A. A1 - Tluczykont, M. A1 - Todero Peixoto, C. J. A1 - Tokanai, F. A1 - Tokarz, M. A1 - Toma, K. A1 - Torii, K. A1 - Tornikoski, M. A1 - Torres, D. F. A1 - Torres, M. A1 - Tosti, G. A1 - Totani, T. A1 - Toussenel, C. A1 - Tovmassian, G. A1 - Travnicek, P. A1 - Trifoglio, M. A1 - Troyano, I. A1 - Tsinganos, K. A1 - Ueno, H. A1 - Umehara, K. A1 - Upadhya, S. S. A1 - Usher, T. A1 - Uslenghi, M. A1 - Valdes-Galicia, J. F. A1 - Vallania, P. A1 - Vallejo, G. A1 - van Driel, W. A1 - van Eldik, C. A1 - Vandenbrouke, J. A1 - Vanderwalt, J. A1 - Vankov, H. A1 - Vasileiadis, G. A1 - Vassiliev, V. A1 - Veberic, D. A1 - Vegas, I. A1 - Vercellone, S. A1 - Vergani, S. A1 - Veyssiere, C. A1 - Vialle, J. P. A1 - Viana, A. A1 - Videla, M. A1 - Vincent, P. A1 - Vincent, S. A1 - Vink, J. A1 - Vlahakis, N. A1 - Vlahos, L. A1 - Vogler, P. A1 - Vollhardt, A. A1 - von Gunten, H. P. A1 - Vorobiov, S. A1 - Vuerli, C. A1 - Waegebaert, V. A1 - Wagner, R. A1 - Wagner, R. G. A1 - Wagner, S. A1 - Wakely, S. P. A1 - Walter, R. A1 - Walther, T. A1 - Warda, K. A1 - Warwick, R. A1 - Wawer, P. A1 - Wawrzaszek, R. A1 - Webb, N. A1 - Wegner, P. A1 - Weinstein, A. A1 - Weitzel, Q. A1 - Welsing, R. A1 - Werner, M. A1 - Wetteskind, H. A1 - White, R. A1 - Wierzcholska, A. A1 - Wiesand, S. A1 - Wilkinson, M. A1 - Williams, D. A. A1 - Willingale, R. A1 - Winiarski, K. A1 - Wischnewski, R. A1 - Wisniewski, L. A1 - Wood, M. A1 - Woernlein, A. A1 - Xiong, Q. A1 - Yadav, K. K. A1 - Yamamoto, H. A1 - Yamamoto, T. A1 - Yamazaki, R. A1 - Yanagita, S. A1 - Yebras, J. M. A1 - Yelos, D. A1 - Yoshida, A. A1 - Yoshida, T. A1 - Yoshikoshi, T. A1 - Zabalza, V. A1 - Zacharias, M. A1 - Zajczyk, A. A1 - Zanin, R. A1 - Zdziarski, A. A1 - Zech, Alraune A1 - Zhao, A. A1 - Zhou, X. A1 - Zietara, K. A1 - Ziolkowski, J. A1 - Ziolkowski, P. A1 - Zitelli, V. A1 - Zurbach, C. A1 - Zychowski, P. T1 - Introducing the CTA concept T2 - Astroparticle physics N2 - The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. KW - TeV gamma-ray astronomy KW - Air showers KW - Cherenkov Telescopes Y1 - 2013 U6 - https://doi.org/10.1016/j.astropartphys.2013.01.007 SN - 0927-6505 SN - 1873-2852 VL - 43 IS - 2 SP - 3 EP - 18 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Actis, M. A1 - Agnetta, G. 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A1 - Elles, S. A1 - Emmanoulopoulos, D. A1 - Enomoto, R. A1 - Ernenwein, J. -P. A1 - Errando, M. A1 - Etchegoyen, A. A1 - Falcone, A. D. A1 - Farakos, K. A1 - Farnier, C. A1 - Federici, S. A1 - Feinstein, F. A1 - Ferenc, D. A1 - Fillin-Martino, E. A1 - Fink, D. A1 - Finley, C. A1 - Finley, J. P. A1 - Firpo, R. A1 - Florin, D. A1 - Foehr, C. A1 - Fokitis, E. A1 - Font, Ll. A1 - Fontaine, G. A1 - Fontana, A. A1 - Foerster, A. A1 - Fortson, L. A1 - Fouque, N. A1 - Fransson, C. A1 - Fraser, G. W. A1 - Fresnillo, L. A1 - Fruck, C. A1 - Fujita, Y. A1 - Fukazawa, Y. A1 - Funk, S. A1 - Gaebele, W. A1 - Gabici, S. A1 - Gadola, A. A1 - Galante, N. A1 - Gallant, Y. A1 - Garcia, B. A1 - Garcia Lopez, R. J. A1 - Garrido, D. A1 - Garrido, L. A1 - Gascon, D. A1 - Gasq, C. A1 - Gaug, M. A1 - Gaweda, J. A1 - Geffroy, N. A1 - Ghag, C. A1 - Ghedina, A. A1 - Ghigo, M. A1 - Gianakaki, E. A1 - Giarrusso, S. A1 - Giavitto, G. A1 - Giebels, B. A1 - Giro, E. A1 - Giubilato, P. A1 - Glanzman, T. A1 - Glicenstein, J. -F. A1 - Gochna, M. A1 - Golev, V. A1 - Gomez Berisso, M. A1 - Gonzalez, A. A1 - Gonzalez, F. A1 - Granena, F. A1 - Graciani, R. A1 - Granot, J. A1 - Gredig, R. A1 - Green, A. A1 - Greenshaw, T. A1 - Grimm, O. A1 - Grube, J. A1 - Grudzinska, M. A1 - Grygorczuk, J. A1 - Guarino, V. A1 - Guglielmi, L. A1 - Guilloux, F. A1 - Gunji, S. A1 - Gyuk, G. A1 - Hadasch, D. A1 - Haefner, D. A1 - Hagiwara, R. A1 - Hahn, J. A1 - Hallgren, A. A1 - Hara, S. A1 - Hardcastle, M. J. A1 - Hassan, T. A1 - Haubold, T. A1 - Hauser, M. A1 - Hayashida, M. A1 - Heller, R. A1 - Henri, G. A1 - Hermann, G. A1 - Herrero, A. A1 - Hinton, James Anthony A1 - Hoffmann, D. A1 - Hofmann, W. A1 - Hofverberg, P. A1 - Horns, D. A1 - Hrupec, D. A1 - Huan, H. A1 - Huber, B. A1 - Huet, J. -M. A1 - Hughes, G. A1 - Hultquist, K. A1 - Humensky, T. B. A1 - Huppert, J. -F. A1 - Ibarra, A. A1 - Illa, J. M. A1 - Ingjald, J. A1 - Inoue, S. A1 - Inoue, Y. A1 - Ioka, K. A1 - Jablonski, C. A1 - Jacholkowska, A. A1 - Janiak, M. A1 - Jean, P. A1 - Jensen, H. A1 - Jogler, T. A1 - Jung, I. A1 - Kaaret, P. A1 - Kabuki, S. A1 - Kakuwa, J. A1 - Kalkuhl, C. A1 - Kankanyan, R. A1 - Kapala, M. A1 - Karastergiou, A. A1 - Karczewski, M. A1 - Karkar, S. A1 - Karlsson, N. A1 - Kasperek, J. A1 - Katagiri, H. A1 - Katarzynski, K. A1 - Kawanaka, N. A1 - Kedziora, B. A1 - Kendziorra, E. A1 - Khelifi, B. A1 - Kieda, D. A1 - Kifune, T. A1 - Kihm, T. A1 - Klepser, S. A1 - Kluzniak, W. A1 - Knapp, J. A1 - Knappy, A. R. A1 - Kneiske, T. A1 - Knoedlseder, J. A1 - Koeck, F. A1 - Kodani, K. A1 - Kohri, K. A1 - Kokkotas, K. A1 - Komin, N. A1 - Konopelko, A. A1 - Kosack, K. A1 - Kossakowski, R. A1 - Kostka, P. A1 - Kotula, J. A1 - Kowal, G. A1 - Koziol, J. A1 - Kraehenbuehl, T. A1 - Krause, J. A1 - Krawczynski, H. A1 - Krennrich, F. A1 - Kretzschmann, A. A1 - Kubo, H. A1 - Kudryavtsev, V. A. A1 - Kushida, J. A1 - La Barbera, N. A1 - La Parola, V. A1 - La Rosa, G. A1 - Lopez, A. A1 - Lamanna, G. A1 - Laporte, P. A1 - Lavalley, C. A1 - Le Flour, T. A1 - Le Padellec, A. A1 - Lenain, J. -P. A1 - Lessio, L. A1 - Lieunard, B. A1 - Lindfors, E. A1 - Liolios, A. A1 - Lohse, T. A1 - Lombardi, S. A1 - Lopatin, A. A1 - Lorenz, E. A1 - Lubinski, P. A1 - Luz, O. A1 - Lyard, E. A1 - Maccarone, M. C. A1 - Maccarone, T. A1 - Maier, G. A1 - Majumdar, P. A1 - Maltezos, S. A1 - Malkiewicz, P. A1 - Mana, C. A1 - Manalaysay, A. A1 - Maneva, G. A1 - Mangano, A. A1 - Manigot, P. A1 - Marin, J. A1 - Mariotti, M. A1 - Markoff, S. A1 - Martinez, G. A1 - Martinez, M. A1 - Mastichiadis, A. A1 - Matsumoto, H. A1 - Mattiazzo, S. A1 - Mazin, D. A1 - McComb, T. J. L. A1 - McCubbin, N. A1 - McHardy, I. A1 - Medina, C. A1 - Melkumyan, D. A1 - Mendes, A. A1 - Mertsch, P. A1 - Meucci, M. A1 - Michalowski, J. A1 - Micolon, P. A1 - Mineo, T. A1 - Mirabal, N. A1 - Mirabel, F. A1 - Miranda, J. M. A1 - Mirzoyan, R. A1 - Mizuno, T. A1 - Moal, B. A1 - Moderski, R. A1 - Molinari, E. A1 - Monteiro, I. A1 - Moralejo, A. A1 - Morello, C. A1 - Mori, K. A1 - Motta, G. A1 - Mottez, F. A1 - Moulin, Emmanuel A1 - Mukherjee, R. A1 - Munar, P. A1 - Muraishi, H. A1 - Murase, K. A1 - Murphy, A. Stj. A1 - Nagataki, S. A1 - Naito, T. A1 - Nakamori, T. A1 - Nakayama, K. A1 - Naumann, C. L. A1 - Naumann, D. A1 - Nayman, P. A1 - Nedbal, D. A1 - Niedzwiecki, A. A1 - Niemiec, J. A1 - Nikolaidis, A. A1 - Nishijima, K. A1 - Nolan, S. J. A1 - Nowak, N. A1 - O'Brien, P. T. A1 - Ochoa, I. A1 - Ohira, Y. A1 - Ohishi, M. A1 - Ohka, H. A1 - Okumura, A. A1 - Olivetto, C. A1 - Ong, R. A. A1 - Orito, R. A1 - Orr, M. A1 - Osborne, J. P. A1 - Ostrowski, M. A1 - Otero, L. A1 - Otte, A. N. A1 - Ovcharov, E. A1 - Oya, I. A1 - Ozieblo, A. A1 - Paiano, S. A1 - Pallota, J. A1 - Panazol, J. L. A1 - Paneque, D. A1 - Panter, M. A1 - Paoletti, R. A1 - Papyan, G. A1 - Paredes, J. M. A1 - Pareschi, G. A1 - Parsons, R. D. A1 - Arribas, M. Paz A1 - Pedaletti, G. A1 - Pepato, A. A1 - Persic, M. A1 - Petrucci, P. O. A1 - Peyaud, B. A1 - Piechocki, W. A1 - Pita, S. A1 - Pivato, G. A1 - Platos, L. A1 - Platzer, R. A1 - Pogosyan, L. A1 - Pohl, Martin A1 - Pojmanski, G. A1 - Ponz, J. D. A1 - Potter, W. A1 - Prandini, E. A1 - Preece, R. A1 - Prokoph, H. A1 - Puehlhofer, G. A1 - Punch, M. A1 - Quel, E. A1 - Quirrenbach, A. A1 - Rajda, P. A1 - Rando, R. A1 - Rataj, M. A1 - Raue, M. A1 - Reimann, C. A1 - Reimann, O. A1 - Reimer, A. A1 - Reimer, O. A1 - Renaud, M. A1 - Renner, S. A1 - Reymond, J. -M. A1 - Rhode, W. A1 - Ribo, M. A1 - Ribordy, M. A1 - Rico, J. A1 - Rieger, F. A1 - Ringegni, P. A1 - Ripken, J. A1 - Ristori, P. A1 - Rivoire, S. A1 - Rob, L. A1 - Rodriguez, S. A1 - Roeser, U. A1 - Romano, Patrizia A1 - Romero, G. E. A1 - Rosier-Lees, S. A1 - Rovero, A. C. A1 - Roy, F. A1 - Royer, S. A1 - Rudak, B. A1 - Rulten, C. B. A1 - Ruppel, J. A1 - Russo, F. A1 - Ryde, F. A1 - Sacco, B. A1 - Saggion, A. A1 - Sahakian, V. A1 - Saito, K. A1 - Saito, T. A1 - Sakaki, N. A1 - Salazar, E. A1 - Salini, A. A1 - Sanchez, F. A1 - Sanchez Conde, M. A. A1 - Santangelo, Andrea A1 - Santos, E. M. A1 - Sanuy, A. A1 - Sapozhnikov, L. A1 - Sarkar, S. A1 - Scalzotto, V. A1 - Scapin, V. A1 - Scarcioffolo, M. A1 - Schanz, T. A1 - Schlenstedt, S. A1 - Schlickeiser, R. A1 - Schmidt, T. A1 - Schmoll, J. A1 - Schroedter, M. A1 - Schultz, C. A1 - Schultze, J. A1 - Schulz, A. A1 - Schwanke, U. A1 - Schwarzburg, S. A1 - Schweizer, T. A1 - Seiradakis, J. A1 - Selmane, S. A1 - Seweryn, K. A1 - Shayduk, M. A1 - Shellard, R. C. A1 - Shibata, T. A1 - Sikora, M. A1 - Silk, J. A1 - Sillanpaa, A. A1 - Sitarek, J. A1 - Skole, C. A1 - Smith, N. A1 - Sobczynska, D. A1 - Sofo Haro, M. A1 - Sol, H. A1 - Spanier, F. A1 - Spiga, D. A1 - Spyrou, S. A1 - Stamatescu, V. A1 - Stamerra, A. A1 - Starling, R. L. C. A1 - Stawarz, L. A1 - Steenkamp, R. A1 - Stegmann, Christian A1 - Steiner, S. A1 - Stergioulas, N. A1 - Sternberger, R. A1 - Stinzing, F. A1 - Stodulski, M. A1 - Straumann, U. A1 - Suarez, A. A1 - Suchenek, M. A1 - Sugawara, R. A1 - Sulanke, K. H. A1 - Sun, S. A1 - Supanitsky, A. D. A1 - Sutcliffe, P. A1 - Szanecki, M. A1 - Szepieniec, T. A1 - Szostek, A. A1 - Szymkowiak, A. A1 - Tagliaferri, G. A1 - Tajima, H. A1 - Takahashi, H. A1 - Takahashi, K. A1 - Takalo, L. A1 - Takami, H. A1 - Talbot, R. G. A1 - Tam, P. H. A1 - Tanaka, M. A1 - Tanimori, T. A1 - Tavani, M. A1 - Tavernet, J. -P. A1 - Tchernin, C. A1 - Tejedor, L. A. A1 - Telezhinsky, Igor O. A1 - Temnikov, P. A1 - Tenzer, C. A1 - Terada, Y. A1 - Terrier, R. A1 - Teshima, M. A1 - Testa, V. A1 - Tibaldo, L. A1 - Tibolla, O. A1 - Tluczykont, M. A1 - Peixoto, C. J. Todero A1 - Tokanai, F. A1 - Tokarz, M. A1 - Toma, K. A1 - Torres, D. F. A1 - Tosti, G. A1 - Totani, T. A1 - Toussenel, F. A1 - Vallania, P. A1 - Vallejo, G. A1 - van der Walt, J. A1 - van Eldik, C. A1 - Vandenbroucke, J. A1 - Vankov, H. A1 - Vasileiadis, G. A1 - Vassiliev, V. V. A1 - Vegas, I. A1 - Venter, L. A1 - Vercellone, S. A1 - Veyssiere, C. A1 - Vialle, J. P. A1 - Videla, M. A1 - Vincent, P. A1 - Vink, J. A1 - Vlahakis, N. A1 - Vlahos, L. A1 - Vogler, P. A1 - Vollhardt, A. A1 - Volpe, F. A1 - Von Gunten, H. P. A1 - Vorobiov, S. A1 - Wagner, S. A1 - Wagner, R. M. A1 - Wagner, B. A1 - Wakely, S. P. A1 - Walter, P. A1 - Walter, R. A1 - Warwick, R. A1 - Wawer, P. A1 - Wawrzaszek, R. A1 - Webb, N. A1 - Wegner, P. A1 - Weinstein, A. A1 - Weitzel, Q. A1 - Welsing, R. A1 - Wetteskind, H. A1 - White, R. A1 - Wierzcholska, A. A1 - Wilkinson, M. I. A1 - Williams, D. A. A1 - Winde, M. A1 - Wischnewski, R. A1 - Wisniewski, L. A1 - Wolczko, A. A1 - Wood, M. A1 - Xiong, Q. A1 - Yamamoto, T. A1 - Yamaoka, K. A1 - Yamazaki, R. A1 - Yanagita, S. A1 - Yoffo, B. A1 - Yonetani, M. A1 - Yoshida, A. A1 - Yoshida, T. A1 - Yoshikoshi, T. A1 - Zabalza, V. A1 - Zagdanski, A. A1 - Zajczyk, A. A1 - Zdziarski, A. A1 - Zech, Alraune A1 - Zietara, K. A1 - Ziolkowski, P. A1 - Zitelli, V. A1 - Zychowski, P. T1 - Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy JF - Experimental astronomy : an international journal on astronomical instrumentation and data analysis N2 - Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA. KW - Ground based gamma ray astronomy KW - Next generation Cherenkov telescopes KW - Design concepts Y1 - 2011 U6 - https://doi.org/10.1007/s10686-011-9247-0 SN - 0922-6435 SN - 1572-9508 VL - 32 IS - 3 SP - 193 EP - 316 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Aarts, Alexander A. A1 - Anderson, Joanna E. A1 - Anderson, Christopher J. A1 - Attridge, Peter R. A1 - Attwood, Angela A1 - Axt, Jordan A1 - Babel, Molly A1 - Bahnik, Stepan A1 - Baranski, Erica A1 - Barnett-Cowan, Michael A1 - Bartmess, Elizabeth A1 - Beer, Jennifer A1 - Bell, Raoul A1 - Bentley, Heather A1 - Beyan, Leah A1 - Binion, Grace A1 - Borsboom, Denny A1 - Bosch, Annick A1 - Bosco, Frank A. A1 - Bowman, Sara D. A1 - Brandt, Mark J. A1 - Braswell, Erin A1 - Brohmer, Hilmar A1 - Brown, Benjamin T. A1 - Brown, Kristina A1 - Bruening, Jovita A1 - Calhoun-Sauls, Ann A1 - Callahan, Shannon P. A1 - Chagnon, Elizabeth A1 - Chandler, Jesse A1 - Chartier, Christopher R. A1 - Cheung, Felix A1 - Christopherson, Cody D. A1 - Cillessen, Linda A1 - Clay, Russ A1 - Cleary, Hayley A1 - Cloud, Mark D. A1 - Cohn, Michael A1 - Cohoon, Johanna A1 - Columbus, Simon A1 - Cordes, Andreas A1 - Costantini, Giulio A1 - Alvarez, Leslie D. Cramblet A1 - Cremata, Ed A1 - Crusius, Jan A1 - DeCoster, Jamie A1 - DeGaetano, Michelle A. A1 - Della Penna, Nicolas A1 - den Bezemer, Bobby A1 - Deserno, Marie K. A1 - Devitt, Olivia A1 - Dewitte, Laura A1 - Dobolyi, David G. A1 - Dodson, Geneva T. A1 - Donnellan, M. Brent A1 - Donohue, Ryan A1 - Dore, Rebecca A. A1 - Dorrough, Angela A1 - Dreber, Anna A1 - Dugas, Michelle A1 - Dunn, Elizabeth W. A1 - Easey, Kayleigh A1 - Eboigbe, Sylvia A1 - Eggleston, Casey A1 - Embley, Jo A1 - Epskamp, Sacha A1 - Errington, Timothy M. A1 - Estel, Vivien A1 - Farach, Frank J. A1 - Feather, Jenelle A1 - Fedor, Anna A1 - Fernandez-Castilla, Belen A1 - Fiedler, Susann A1 - Field, James G. A1 - Fitneva, Stanka A. A1 - Flagan, Taru A1 - Forest, Amanda L. A1 - Forsell, Eskil A1 - Foster, Joshua D. A1 - Frank, Michael C. A1 - Frazier, Rebecca S. A1 - Fuchs, Heather A1 - Gable, Philip A1 - Galak, Jeff A1 - Galliani, Elisa Maria A1 - Gampa, Anup A1 - Garcia, Sara A1 - Gazarian, Douglas A1 - Gilbert, Elizabeth A1 - Giner-Sorolla, Roger A1 - Glöckner, Andreas A1 - Göllner, Lars A1 - Goh, Jin X. A1 - Goldberg, Rebecca A1 - Goodbourn, Patrick T. A1 - Gordon-McKeon, Shauna A1 - Gorges, Bryan A1 - Gorges, Jessie A1 - Goss, Justin A1 - Graham, Jesse A1 - Grange, James A. A1 - Gray, Jeremy A1 - Hartgerink, Chris A1 - Hartshorne, Joshua A1 - Hasselman, Fred A1 - Hayes, Timothy A1 - Heikensten, Emma A1 - Henninger, Felix A1 - Hodsoll, John A1 - Holubar, Taylor A1 - Hoogendoorn, Gea A1 - Humphries, Denise J. A1 - Hung, Cathy O. -Y. A1 - Immelman, Nathali A1 - Irsik, Vanessa C. A1 - Jahn, Georg A1 - Jaekel, Frank A1 - Jekel, Marc A1 - Johannesson, Magnus A1 - Johnson, Larissa G. A1 - Johnson, David J. A1 - Johnson, Kate M. A1 - Johnston, William J. A1 - Jonas, Kai A1 - Joy-Gaba, Jennifer A. A1 - Kappes, Heather Barry A1 - Kelso, Kim A1 - Kidwell, Mallory C. A1 - Kim, Seung Kyung A1 - Kirkhart, Matthew A1 - Kleinberg, Bennett A1 - Knezevic, Goran A1 - Kolorz, Franziska Maria A1 - Kossakowski, Jolanda J. A1 - Krause, Robert Wilhelm A1 - Krijnen, Job A1 - Kuhlmann, Tim A1 - Kunkels, Yoram K. A1 - Kyc, Megan M. A1 - Lai, Calvin K. A1 - Laique, Aamir A1 - Lakens, Daniel A1 - Lane, Kristin A. A1 - Lassetter, Bethany A1 - Lazarevic, Ljiljana B. A1 - LeBel, Etienne P. A1 - Lee, Key Jung A1 - Lee, Minha A1 - Lemm, Kristi A1 - Levitan, Carmel A. A1 - Lewis, Melissa A1 - Lin, Lin A1 - Lin, Stephanie A1 - Lippold, Matthias A1 - Loureiro, Darren A1 - Luteijn, Ilse A1 - Mackinnon, Sean A1 - Mainard, Heather N. A1 - Marigold, Denise C. A1 - Martin, Daniel P. A1 - Martinez, Tylar A1 - Masicampo, E. J. A1 - Matacotta, Josh A1 - Mathur, Maya A1 - May, Michael A1 - Mechin, Nicole A1 - Mehta, Pranjal A1 - Meixner, Johannes A1 - Melinger, Alissa A1 - Miller, Jeremy K. A1 - Miller, Mallorie A1 - Moore, Katherine A1 - Möschl, Marcus A1 - Motyl, Matt A1 - Müller, Stephanie M. A1 - Munafo, Marcus A1 - Neijenhuijs, Koen I. A1 - Nervi, Taylor A1 - Nicolas, Gandalf A1 - Nilsonne, Gustav A1 - Nosek, Brian A. A1 - Nuijten, Michele B. A1 - Olsson, Catherine A1 - Osborne, Colleen A1 - Ostkamp, Lutz A1 - Pavel, Misha A1 - Penton-Voak, Ian S. A1 - Perna, Olivia A1 - Pernet, Cyril A1 - Perugini, Marco A1 - Pipitone, R. Nathan A1 - Pitts, Michael A1 - Plessow, Franziska A1 - Prenoveau, Jason M. A1 - Rahal, Rima-Maria A1 - Ratliff, Kate A. A1 - Reinhard, David A1 - Renkewitz, Frank A1 - Ricker, Ashley A. A1 - Rigney, Anastasia A1 - Rivers, Andrew M. A1 - Roebke, Mark A1 - Rutchick, Abraham M. A1 - Ryan, Robert S. A1 - Sahin, Onur A1 - Saide, Anondah A1 - Sandstrom, Gillian M. A1 - Santos, David A1 - Saxe, Rebecca A1 - Schlegelmilch, Rene A1 - Schmidt, Kathleen A1 - Scholz, Sabine A1 - Seibel, Larissa A1 - Selterman, Dylan Faulkner A1 - Shaki, Samuel A1 - Simpson, William B. A1 - Sinclair, H. Colleen A1 - Skorinko, Jeanine L. M. A1 - Slowik, Agnieszka A1 - Snyder, Joel S. A1 - Soderberg, Courtney A1 - Sonnleitner, Carina A1 - Spencer, Nick A1 - Spies, Jeffrey R. A1 - Steegen, Sara A1 - Stieger, Stefan A1 - Strohminger, Nina A1 - Sullivan, Gavin B. A1 - Talhelm, Thomas A1 - Tapia, Megan A1 - te Dorsthorst, Anniek A1 - Thomae, Manuela A1 - Thomas, Sarah L. A1 - Tio, Pia A1 - Traets, Frits A1 - Tsang, Steve A1 - Tuerlinckx, Francis A1 - Turchan, Paul A1 - Valasek, Milan A1 - Van Aert, Robbie A1 - van Assen, Marcel A1 - van Bork, Riet A1 - van de Ven, Mathijs A1 - van den Bergh, Don A1 - van der Hulst, Marije A1 - van Dooren, Roel A1 - van Doorn, Johnny A1 - van Renswoude, Daan R. A1 - van Rijn, Hedderik A1 - Vanpaemel, Wolf A1 - Echeverria, Alejandro Vasquez A1 - Vazquez, Melissa A1 - Velez, Natalia A1 - Vermue, Marieke A1 - Verschoor, Mark A1 - Vianello, Michelangelo A1 - Voracek, Martin A1 - Vuu, Gina A1 - Wagenmakers, Eric-Jan A1 - Weerdmeester, Joanneke A1 - Welsh, Ashlee A1 - Westgate, Erin C. A1 - Wissink, Joeri A1 - Wood, Michael A1 - Woods, Andy A1 - Wright, Emily A1 - Wu, Sining A1 - Zeelenberg, Marcel A1 - Zuni, Kellylynn T1 - Estimating the reproducibility of psychological science JF - Science N2 - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams. Y1 - 2015 U6 - https://doi.org/10.1126/science.aac4716 SN - 1095-9203 SN - 0036-8075 VL - 349 IS - 6251 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Aldoretta, E. J. A1 - St-Louis, N. A1 - Richardson, N. D. A1 - Moffat, Anthony F. J. A1 - Eversberg, T. A1 - Hill, G. M. A1 - Shenar, Tomer A1 - Artigau, E. A1 - Gauza, B. A1 - Knapen, J. H. A1 - Kubat, Jiří A1 - Kubatova, Brankica A1 - Maltais-Tariant, R. A1 - Munoz, M. A1 - Pablo, H. A1 - Ramiaramanantsoa, T. A1 - Richard-Laferriere, A. A1 - Sablowski, D. P. A1 - Simon-Diaz, S. A1 - St-Jean, L. A1 - Bolduan, F. A1 - Dias, F. M. A1 - Dubreuil, P. A1 - Fuchs, D. A1 - Garrel, T. A1 - Grutzeck, G. A1 - Hunger, T. A1 - Kuesters, D. A1 - Langenbrink, M. A1 - Leadbeater, R. A1 - Li, D. A1 - Lopez, A. A1 - Mauclaire, B. A1 - Moldenhawer, T. A1 - Potter, M. A1 - dos Santos, E. M. A1 - Schanne, L. A1 - Schmidt, J. A1 - Sieske, H. A1 - Strachan, J. A1 - Stinner, E. A1 - Stinner, P. A1 - Stober, B. A1 - Strandbaek, K. A1 - Syder, T. A1 - Verilhac, D. A1 - Waldschlaeger, U. A1 - Weiss, D. A1 - Wendt, A. T1 - An extensive spectroscopic time series of three Wolf-Rayet stars - I. The lifetime of large-scale structures in the wind of WR 134 JF - Monthly notices of the Royal Astronomical Society N2 - During the summer of 2013, a 4-month spectroscopic campaign took place to observe the variabilities in three Wolf-Rayet stars. The spectroscopic data have been analysed for WR 134 (WN6b), to better understand its behaviour and long-term periodicity, which we interpret as arising from corotating interaction regions (CIRs) in the wind. By analysing the variability of the He ii lambda 5411 emission line, the previously identified period was refined to P = 2.255 +/- 0.008 (s.d.) d. The coherency time of the variability, which we associate with the lifetime of the CIRs in the wind, was deduced to be 40 +/- 6 d, or similar to 18 cycles, by cross-correlating the variability patterns as a function of time. When comparing the phased observational grey-scale difference images with theoretical grey-scales previously calculated from models including CIRs in an optically thin stellar wind, we find that two CIRs were likely present. A separation in longitude of Delta I center dot a parts per thousand integral 90A degrees was determined between the two CIRs and we suggest that the different maximum velocities that they reach indicate that they emerge from different latitudes. We have also been able to detect observational signatures of the CIRs in other spectral lines (C iv lambda lambda 5802,5812 and He i lambda 5876). Furthermore, a DAC was found to be present simultaneously with the CIR signatures detected in the He i lambda 5876 emission line which is consistent with the proposed geometry of the large-scale structures in the wind. Small-scale structures also show a presence in the wind, simultaneously with the larger scale structures, showing that they do in fact co-exist. KW - instabilities KW - methods: data analysis KW - techniques: spectroscopic KW - stars: individual: WR 134 KW - stars: massive KW - stars: Wolf-Rayet Y1 - 2016 U6 - https://doi.org/10.1093/mnras/stw1188 SN - 0035-8711 SN - 1365-2966 VL - 460 SP - 3407 EP - 3417 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Gorski, Mathias A1 - Jung, Bettina A1 - Li, Yong A1 - Matias-Garcia, Pamela R. A1 - Wuttke, Matthias A1 - Coassin, Stefan A1 - Thio, Chris H. L. A1 - Kleber, Marcus E. A1 - Winkler, Thomas W. A1 - Wanner, Veronika A1 - Chai, Jin-Fang A1 - Chu, Audrey Y. A1 - Cocca, Massimiliano A1 - Feitosa, Mary F. A1 - Ghasemi, Sahar A1 - Hoppmann, Anselm A1 - Horn, Katrin A1 - Li, Man A1 - Nutile, Teresa A1 - Scholz, Markus A1 - Sieber, Karsten B. A1 - Teumer, Alexander A1 - Tin, Adrienne A1 - Wang, Judy A1 - Tayo, Bamidele O. A1 - Ahluwalia, Tarunveer S. A1 - Almgren, Peter A1 - Bakker, Stephan J. L. A1 - Banas, Bernhard A1 - Bansal, Nisha A1 - Biggs, Mary L. A1 - Boerwinkle, Eric A1 - Böttinger, Erwin A1 - Brenner, Hermann A1 - Carroll, Robert J. A1 - Chalmers, John A1 - Chee, Miao-Li A1 - Chee, Miao-Ling A1 - Cheng, Ching-Yu A1 - Coresh, Josef A1 - de Borst, Martin H. A1 - Degenhardt, Frauke A1 - Eckardt, Kai-Uwe A1 - Endlich, Karlhans A1 - Franke, Andre A1 - Freitag-Wolf, Sandra A1 - Gampawar, Piyush A1 - Gansevoort, Ron T. A1 - Ghanbari, Mohsen A1 - Gieger, Christian A1 - Hamet, Pavel A1 - Ho, Kevin A1 - Hofer, Edith A1 - Holleczek, Bernd A1 - Foo, Valencia Hui Xian A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Josyula, Navya Shilpa A1 - Kahonen, Mika A1 - Khor, Chiea-Chuen A1 - Koenig, Wolfgang A1 - Kramer, Holly A1 - Kraemer, Bernhard K. A1 - Kuehnel, Brigitte A1 - Lange, Leslie A. A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Loos, Ruth J. F. A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Milaneschi, Yuri A1 - Mishra, Pashupati P. A1 - Mononen, Nina A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - O'Donoghue, Michelle L. A1 - Orho-Melander, Marju A1 - Pendergrass, Sarah A. A1 - Penninx, Brenda W. J. H. A1 - Preuss, Michael H. A1 - Psaty, Bruce M. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Rosenkranz, Alexander R. A1 - Rossing, Peter A1 - Rotter, Jerome A1 - Sabanayagam, Charumathi A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Schoettker, Ben A1 - Schulz, Christina-Alexandra A1 - Sedaghat, Sanaz A1 - Shaffer, Christian M. A1 - Strauch, Konstantin A1 - Szymczak, Silke A1 - Taylor, Kent D. A1 - Tremblay, Johanne A1 - Chaker, Layal A1 - van der Harst, Pim A1 - van der Most, Peter J. A1 - Verweij, Niek A1 - Voelker, Uwe A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Waterworth, Dawn M. A1 - White, Harvey D. A1 - Wilson, James G. A1 - Wong, Tien-Yin A1 - Woodward, Mark A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Yan A1 - Snieder, Harold A1 - Wanner, Christoph A1 - Boger, Carsten A. A1 - Kottgen, Anna A1 - Kronenberg, Florian A1 - Pattaro, Cristian A1 - Heid, Iris M. T1 - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline T2 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät N2 - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function. T3 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 KW - acute kidney injury KW - end-stage kidney disease KW - genome-wide association KW - study KW - rapid eGFRcrea decline Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379 IS - 19 ER - TY - JOUR A1 - Gorski, Mathias A1 - Jung, Bettina A1 - Li, Yong A1 - Matias-Garcia, Pamela R. A1 - Wuttke, Matthias A1 - Coassin, Stefan A1 - Thio, Chris H. L. A1 - Kleber, Marcus E. A1 - Winkler, Thomas W. A1 - Wanner, Veronika A1 - Chai, Jin-Fang A1 - Chu, Audrey Y. A1 - Cocca, Massimiliano A1 - Feitosa, Mary F. A1 - Ghasemi, Sahar A1 - Hoppmann, Anselm A1 - Horn, Katrin A1 - Li, Man A1 - Nutile, Teresa A1 - Scholz, Markus A1 - Sieber, Karsten B. A1 - Teumer, Alexander A1 - Tin, Adrienne A1 - Wang, Judy A1 - Tayo, Bamidele O. A1 - Ahluwalia, Tarunveer S. A1 - Almgren, Peter A1 - Bakker, Stephan J. L. A1 - Banas, Bernhard A1 - Bansal, Nisha A1 - Biggs, Mary L. A1 - Boerwinkle, Eric A1 - Böttinger, Erwin A1 - Brenner, Hermann A1 - Carroll, Robert J. A1 - Chalmers, John A1 - Chee, Miao-Li A1 - Chee, Miao-Ling A1 - Cheng, Ching-Yu A1 - Coresh, Josef A1 - de Borst, Martin H. A1 - Degenhardt, Frauke A1 - Eckardt, Kai-Uwe A1 - Endlich, Karlhans A1 - Franke, Andre A1 - Freitag-Wolf, Sandra A1 - Gampawar, Piyush A1 - Gansevoort, Ron T. A1 - Ghanbari, Mohsen A1 - Gieger, Christian A1 - Hamet, Pavel A1 - Ho, Kevin A1 - Hofer, Edith A1 - Holleczek, Bernd A1 - Foo, Valencia Hui Xian A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Josyula, Navya Shilpa A1 - Kahonen, Mika A1 - Khor, Chiea-Chuen A1 - Koenig, Wolfgang A1 - Kramer, Holly A1 - Kraemer, Bernhard K. A1 - Kuehnel, Brigitte A1 - Lange, Leslie A. A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Loos, Ruth J. F. A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Milaneschi, Yuri A1 - Mishra, Pashupati P. A1 - Mononen, Nina A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - O'Donoghue, Michelle L. A1 - Orho-Melander, Marju A1 - Pendergrass, Sarah A. A1 - Penninx, Brenda W. J. H. A1 - Preuss, Michael H. A1 - Psaty, Bruce M. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Rosenkranz, Alexander R. A1 - Rossing, Peter A1 - Rotter, Jerome A1 - Sabanayagam, Charumathi A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Schoettker, Ben A1 - Schulz, Christina-Alexandra A1 - Sedaghat, Sanaz A1 - Shaffer, Christian M. A1 - Strauch, Konstantin A1 - Szymczak, Silke A1 - Taylor, Kent D. A1 - Tremblay, Johanne A1 - Chaker, Layal A1 - van der Harst, Pim A1 - van der Most, Peter J. A1 - Verweij, Niek A1 - Voelker, Uwe A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Waterworth, Dawn M. A1 - White, Harvey D. A1 - Wilson, James G. A1 - Wong, Tien-Yin A1 - Woodward, Mark A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Yan A1 - Snieder, Harold A1 - Wanner, Christoph A1 - Boger, Carsten A. A1 - Kottgen, Anna A1 - Kronenberg, Florian A1 - Pattaro, Cristian A1 - Heid, Iris M. T1 - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline JF - Kidney international : official journal of the International Society of Nephrology N2 - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function. KW - acute kidney injury KW - end-stage kidney disease KW - genome-wide association KW - study KW - rapid eGFRcrea decline Y1 - 2020 U6 - https://doi.org/10.1016/j.kint.2020.09.030 SN - 0085-2538 SN - 1523-1755 VL - 99 IS - 4 SP - 926 EP - 939 PB - Elsevier CY - New York ER - TY - JOUR A1 - Schmidt, Tobias M. A1 - Hennawi, Joseph F. A1 - Worseck, Gabor A1 - Davies, Frederick B. A1 - Lukic, Zarija A1 - Oñorbe, Jose T1 - Modeling the HeII transverse proximity effect BT - constraints on quasar lifetime and obscuration JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - The He II transverse proximity effect-enhanced He II Ly alpha transmission in a background sightline caused by the ionizing radiation of a foreground quasar-offers a unique opportunity to probe the emission properties of quasars, in particular the emission geometry (obscuration, beaming) and the quasar lifetime. Building on the foreground quasar survey published in Schmidt et al., we present a detailed model of the He II transverse proximity effect, specifically designed to include light travel time effects, finite quasar ages, and quasar obscuration. We postprocess outputs from a cosmological hydrodynamical simulation with a fluctuating He II ultraviolet background model, with the added effect of the radiation from a single bright foreground quasar. We vary the age t(age) and obscured sky fractions Omega(obsc) of the foreground quasar, and explore the resulting effect on the He II transverse proximity effect signal. Fluctuations in intergalactic medium density and the ultraviolet background, as well as the unknown orientation of the foreground quasar, result in a large variance of the He II Ly alpha transmission along the background sightline. We develop a fully Bayesian statistical formalism to compare far-ultraviolet He II Ly alpha transmission spectra of the background quasars to our models, and extract joint constraints on t(age) and Omega(obsc) for the six Schmidt et al. foreground quasars with the highest implied He II photoionization rates. Our analysis suggests a bimodal distribution of quasar emission properties, whereby one foreground quasar, associated with a strong He II transmission spike, is relatively old (22 Myr) and unobscured (Omega(obsc) < 35%), whereas three others are either younger than 10 Myr or highly obscured (Omega(obsc) > 70%). KW - dark ages, reionization, first stars KW - intergalactic medium KW - quasars: general Y1 - 2018 U6 - https://doi.org/10.3847/1538-4357/aac8e4 SN - 0004-637X SN - 1538-4357 VL - 861 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - GEN A1 - Anderson, Christopher J. A1 - Bahnik, Stepan A1 - Barnett-Cowan, Michael A1 - Bosco, Frank A. A1 - Chandler, Jesse A1 - Chartier, Christopher R. A1 - Cheung, Felix A1 - Christopherson, Cody D. A1 - Cordes, Andreas A1 - Cremata, Edward J. A1 - Della Penna, Nicolas A1 - Estel, Vivien A1 - Fedor, Anna A1 - Fitneva, Stanka A. A1 - Frank, Michael C. A1 - Grange, James A. A1 - Hartshorne, Joshua K. A1 - Hasselman, Fred A1 - Henninger, Felix A1 - van der Hulst, Marije A1 - Jonas, Kai J. A1 - Lai, Calvin K. A1 - Levitan, Carmel A. A1 - Miller, Jeremy K. A1 - Moore, Katherine S. A1 - Meixner, Johannes M. A1 - Munafo, Marcus R. A1 - Neijenhuijs, Koen I. A1 - Nilsonne, Gustav A1 - Nosek, Brian A. A1 - Plessow, Franziska A1 - Prenoveau, Jason M. A1 - Ricker, Ashley A. A1 - Schmidt, Kathleen A1 - Spies, Jeffrey R. A1 - Stieger, Stefan A1 - Strohminger, Nina A1 - Sullivan, Gavin B. A1 - van Aert, Robbie C. M. A1 - van Assen, Marcel A. L. M. A1 - Vanpaemel, Wolf A1 - Vianello, Michelangelo A1 - Voracek, Martin A1 - Zuni, Kellylynn T1 - Response to Comment on "Estimating the reproducibility of psychological science" T2 - Science N2 - Gilbert et al. conclude that evidence from the Open Science Collaboration’s Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted. Y1 - 2016 U6 - https://doi.org/10.1126/science.aad9163 SN - 0036-8075 SN - 1095-9203 VL - 351 SP - 1162 EP - 1165 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Tötzke, Christian A1 - Gaiselmann, G. A1 - Osenberg, M. A1 - Arlt, T. A1 - Markötter, H. A1 - Hilger, A. A1 - Kupsch, Andreas A1 - Müller, B. R. A1 - Schmidt, V. A1 - Lehnert, W. A1 - Manke, Ingo T1 - Influence of hydrophobic treatment on the structure of compressed gas diffusion layers JF - Journal of power sources : the international journal on the science and technology of electrochemical energy systems N2 - Carbon fiber based felt materials are widely used as gas diffusion layer (GDL) in fuel cells. Their transport properties can be adjusted by adding hydrophobic agents such as polytetrafluoroethylene (PTFE). We present a synchrotron X-ray tomographic study on the felt material Freudenberg H2315 with different PIPE finishing. In this study, we analyze changes in microstructure and shape of GDLs at increasing degree of compression which are related to their specific PTFE load. A dedicated compression device mimicking the channel-land pattern of the flowfield is used to reproduce the inhomogeneous compression found in a fuel cell. Transport relevant geometrical parameters such as porosity, pore size distribution and geometric tortuosity are calculated and consequences for media transport discussed. PTFE finishing results in a marked change of shape of compressed GDLs: surface is smoothed and the invasion of GDL fibers into the flow field channel strongly mitigated. Furthermore, the PTFE impacts the microstructure of the compressed GDL. The number of available wide transport paths is significantly increased as compared to the untreated material. These changes improve the transport capacity liquid water through the GDL and promote the discharge of liquid water droplets from the cell. (C) 2016 Elsevier B.V. All rights reserved. KW - Gas diffusion layer KW - Synchrotron tomography KW - Compression KW - Hydrophobic treatment KW - Water transport Y1 - 2016 U6 - https://doi.org/10.1016/j.jpowsour.2016.05.118 SN - 0378-7753 SN - 1873-2755 VL - 324 SP - 625 EP - 636 PB - Elsevier CY - Amsterdam ER - TY - THES A1 - Schmidt, Björn B. T1 - The Dynamics of M&A Strategy T2 - Europäische Hochschulschriften : Series V Y1 - 2010 SN - 978-3-631-60093-1 SN - 0531-7339 VL - 3366 PB - Lang Peter GmbH Internationaler Verlag der Wissenschaften CY - Frankfurt ER - TY - JOUR A1 - Broscheit, Frank A1 - Bütow, Martin A1 - Englert, Wolfgang A1 - Jahn, Gert A1 - Klohn, Werner A1 - Knitschky, Wolfgang A1 - Reinecke, Hans-Joachim A1 - Müller, Helmut A1 - Reinhardt, Karl Heinz A1 - Schmidt, Marianne A1 - Schmidtke, Kurt-Dietmar A1 - Schöpflin, F. A1 - Starke, Rainer A1 - Vahldiek, B. W. A1 - Wehrs, Klaus A1 - Wetzel, Jürgen T1 - Seydlitz Erdkunde 2 Y1 - 1996 PB - Schroedel CY - Hannover ER - TY - JOUR A1 - Srama, Ralf A1 - Krueger, H. A1 - Yamaguchi, T. A1 - Stephan, T. A1 - Burchell, M. A1 - Kearsley, A. T. A1 - Sterken, V. A1 - Postberg, F. A1 - Kempf, S. A1 - Grün, Eberhard A1 - Altobelli, Nicolas A1 - Ehrenfreund, P. A1 - Dikarev, V. A1 - Horanyi, M. A1 - Sternovsky, Zoltan A1 - Carpenter, J. D. A1 - Westphal, A. A1 - Gainsforth, Z. A1 - Krabbe, A. A1 - Agarwal, Jessica A1 - Yano, H. A1 - Blum, J. A1 - Henkel, H. A1 - Hillier, J. A1 - Hoppe, P. A1 - Trieloff, M. A1 - Hsu, S. A1 - Mocker, A. A1 - Fiege, K. A1 - Green, S. F. A1 - Bischoff, A. A1 - Esposito, F. A1 - Laufer, R. A1 - Hyde, T. W. A1 - Herdrich, G. A1 - Fasoulas, S. A1 - Jaeckel, A. A1 - Jones, G. A1 - Jenniskens, P. A1 - Khalisi, E. A1 - Moragas-Klostermeyer, Georg A1 - Spahn, Frank A1 - Keller, H. U. A1 - Frisch, P. A1 - Levasseur-Regourd, A. C. A1 - Pailer, N. A1 - Altwegg, K. A1 - Engrand, C. A1 - Auer, S. A1 - Silen, J. A1 - Sasaki, S. A1 - Kobayashi, M. A1 - Schmidt, J. A1 - Kissel, J. A1 - Marty, B. A1 - Michel, P. A1 - Palumbo, P. A1 - Vaisberg, O. A1 - Baggaley, J. A1 - Rotundi, A. A1 - Roeser, H. P. T1 - SARIM PLUS-sample return of comet 67P/CG and of interstellar matter JF - EXPERIMENTAL ASTRONOMY N2 - The Stardust mission returned cometary, interplanetary and (probably) interstellar dust in 2006 to Earth that have been analysed in Earth laboratories worldwide. Results of this mission have changed our view and knowledge on the early solar nebula. The Rosetta mission is on its way to land on comet 67P/Churyumov-Gerasimenko and will investigate for the first time in great detail the comet nucleus and its environment starting in 2014. Additional astronomy and planetary space missions will further contribute to our understanding of dust generation, evolution and destruction in interstellar and interplanetary space and provide constraints on solar system formation and processes that led to the origin of life on Earth. One of these missions, SARIM-PLUS, will provide a unique perspective by measuring interplanetary and interstellar dust with high accuracy and sensitivity in our inner solar system between 1 and 2 AU. SARIM-PLUS employs latest in-situ techniques for a full characterisation of individual micrometeoroids (flux, mass, charge, trajectory, composition()) and collects and returns these samples to Earth for a detailed analysis. The opportunity to visit again the target comet of the Rosetta mission 67P/Churyumov-Gerasimeenternko, and to investigate its dusty environment six years after Rosetta with complementary methods is unique and strongly enhances and supports the scientific exploration of this target and the entire Rosetta mission. Launch opportunities are in 2020 with a backup window starting early 2026. The comet encounter occurs in September 2021 and the reentry takes place in early 2024. An encounter speed of 6 km/s ensures comparable results to the Stardust mission. KW - Interstellar dust KW - Cometary dust KW - Churyumov Gerasimenko KW - Interplanetary dust KW - IMF KW - Cosmic vision KW - Sample return KW - Dust collector KW - Mass spectrometry Y1 - 2012 U6 - https://doi.org/10.1007/s10686-011-9285-7 SN - 0922-6435 SN - 1572-9508 VL - 33 IS - 2-3 SP - 723 EP - 751 PB - SPRINGER CY - DORDRECHT ER - TY - JOUR A1 - Sachse, Dirk A1 - Billault, Isabelle A1 - Bowen, Gabriel J. A1 - Chikaraishi, Yoshito A1 - Dawson, Todd E. A1 - Feakins, Sarah J. A1 - Freeman, Katherine H. A1 - Magill, Clayton R. A1 - McInerney, Francesca A. A1 - van der Meer, Marcel T. J. A1 - Polissar, Pratigya A1 - Robins, Richard J. A1 - Sachs, Julian P. A1 - Schmidt, Hanns-Ludwig A1 - Sessions, Alex L. A1 - White, James W. C. A1 - West, Jason B. A1 - Kahmen, Ansgar ED - Jeanloz, R T1 - Molecular Paleohydrology interpreting the Hydrogen- Isotopic Composition of Lipid Biomarkers from Photosynthesizing Organisms JF - Annual review of earth and planetary sciences JF - Annual Review of Earth and Planetary Sciences N2 - Hydrogen-isotopic abundances of lipid biomarkers are emerging as important proxies in the study of ancient environments and ecosystems. A decade ago, pioneering studies made use of new analytical methods and demonstrated that the hydrogen-isotopic composition of individual lipids from aquatic and terrestrial organisms can be related to the composition of their growth (i.e., environmental) water. Subsequently, compound-specific deuterium/hydrogen (D/H) ratios of sedimentary biomarkers have been increasingly used as paleohydrological proxies over a range of geological timescales. Isotopic fractionation observed between hydrogen in environmental water and hydrogen in lipids, however, is sensitive to biochemical, physiological, and environmental influences on the composition of hydrogen available for biosynthesis in cells. Here we review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids-especially n-alkanes-from photosynthesizing organisms, and we provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities. KW - paleoclimate KW - paleoclimate proxy KW - deuterium KW - organic geochemistry Y1 - 2012 SN - 978-0-8243-2040-9 U6 - https://doi.org/10.1146/annurev-earth-042711-105535 SN - 0084-6597 VL - 40 IS - 1 SP - 221 EP - 249 PB - Annual Reviews CY - Palo Alto ER - TY - JOUR A1 - Ellis, S. C. A1 - Bland-Hawthorn, Joss A1 - Lawrence, J. A1 - Horton, A. J. A1 - Trinh, C. A1 - Leon-Saval, S. G. A1 - Shortridge, K. A1 - Bryant, J. A1 - Case, S. A1 - Colless, M. A1 - Couch, W. A1 - Freeman, K. A1 - Gers, L. A1 - Glazebrook, K. A1 - Haynes, R. A1 - Lee, S. A1 - Löhmannsröben, Hans-Gerd A1 - O'Byrne, J. A1 - Miziarski, S. A1 - Roth, M. A1 - Schmidt, B. A1 - Tinney, C. G. A1 - Zheng, J. T1 - Suppression of the near-infrared OH night-sky lines with fibre Bragg gratings - first results JF - Monthly notices of the Royal Astronomical Society N2 - The background noise between 1 and 1.8 ?mu m in ground-based instruments is dominated by atmospheric emission from hydroxyl molecules. We have built and commissioned a new instrument, the Gemini Near-infrared OH Suppression Integral Field Unit (IFU) System (GNOSIS), which suppresses 103 OH doublets between 1.47 and 1.7?mu m by a factor of 1000 with a resolving power of 10?000. We present the first results from the commissioning of GNOSIS using the IRIS2 spectrograph at the Anglo-Australian Telescope. We present measurements of sensitivity, background and throughput. The combined throughput of the GNOSIS fore-optics, grating unit and relay optics is 36?per cent, but this could be improved to 46?per cent with a more optimal design. We measure strong suppression of the OH lines, confirming that OH suppression with fibre Bragg gratings will be a powerful technology for low-resolution spectroscopy. The integrated OH suppressed background between 1.5 and 1.7 mu m is reduced by a factor of 9 compared to a control spectrum using the same system without suppression. The potential of low-resolution OH-suppressed spectroscopy is illustrated with example observations of Seyfert galaxies and a low-mass star. The GNOSIS background is dominated by detector dark current below 1.67 mu m and by thermal emission above 1.67 mu m. After subtracting these, we detect an unidentified residual interline component of 860 +/- 210 photons s-1 m-2?arcsec-2?mu m-1, comparable to previous measurements. This component is equally bright in the suppressed and control spectra. We have investigated the possible source of the interline component, but were unable to discriminate between a possible instrumental artefact and intrinsic atmospheric emission. Resolving the source of this emission is crucial for the design of fully optimized OH suppression spectrographs. The next-generation OH suppression spectrograph will be focused on resolving the source of the interline component, taking advantage of better optimization for a fibre Bragg grating feed incorporating refinements of design based on our findings from GNOSIS. We quantify the necessary improvements for an optimal OH suppressing fibre spectrograph design. KW - atmospheric effects KW - instrumentation: miscellaneous KW - infrared: general Y1 - 2012 U6 - https://doi.org/10.1111/j.1365-2966.2012.21602.x SN - 0035-8711 VL - 425 IS - 3 SP - 1682 EP - 1695 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Schenk, Paul A1 - Hamilton, Douglas P. A1 - Johnson, Robert E. A1 - McKinnon, William B. A1 - Paranicas, Chris A1 - Schmidt, Jürgen A1 - Showalter, Mark R. T1 - Plasma, plumes and rings saturn system dynamics as recorded in global color patterns on its midsize icy satellites JF - Icarus : international journal of solar system studies N2 - New global maps of the five inner midsize icy saturnian satellites, Mimas, Enceladus, Tethys, Dione, and Rhea, have been constructed in three colors (UV, Green and near-IR) at resolutions of 1 km/pixel. The maps reveal prominent global patterns common to several of these satellites but also three major color features unique to specific satellites or satellite subgroups. The most common features among the group are first-order global asymmetries in color properties. This pattern, expressed on Tethys, Dione and Rhea, takes the form of a similar to 1.4-1.8 times enhancement in redness (expressed as IR/UV ratio) of the surface at the center of the trailing hemisphere of motion, and a similar though significantly weaker IR/UV enhancement at the center of the leading hemisphere. The peak in redness on the trailing hemisphere also corresponds to a known decrease in albedo. These double hemispheric asymmetries are attributable to plasma and E-ring grain bombardment on the trailing and leading hemispheres, respectively, for the outer three satellites Tethys, Dione and Rhea, whereas as E-ring bombardment may be focused on the trailing hemisphere of Mimas due to its orbital location interior to Enceladus. The maps also reveal three major deviations from these basic global patterns. We observe the previously known dark bluish leading hemisphere equatorial band on Tethys but have also discovered a similar band on Mimas. Similar in shape, both features match the surface patterns expected for irradiation of the surface by incident MeV electrons that drift in a direction opposite to the plasma flow. The global asymmetry on Enceladus is offset similar to 40 degrees to the west compared to the other satellites. We do not consider Enceladus in detail here, but the global distribution of bluish material can be shown to match the deposition pattern predicted for plume fallback onto the surface (Kempf, S., Beckmann, U., Schmidt, S. [2010]. Icarus 206, 446-457. doi:10.1016/j.icarus.2009.09.016). E-ring deposition on Enceladus thus appears to mask or prevent the formation of the lenses and hemispheric asymmetries we see on the other satellites. Finally, we observe a chain of discrete bluish splotches along the equator of Rhea. Unlike the equatorial bands of Tethys and Mimas, these splotches form a very narrow great circle <= 10-km wide (north-to-south) and appear to be related to surface disruption, exposing fresh, bluish ice on older crater rims. This feature is unique to Rhea and may have formed by impact onto its surface of orbiting material. KW - Satellites, Surfaces KW - Saturn, Satellites KW - Saturn, Rings KW - Enceladus KW - Satellites, Composition KW - Magnetospheres Y1 - 2011 U6 - https://doi.org/10.1016/j.icarus.2010.08.016 SN - 0019-1035 VL - 211 IS - 1 SP - 740 EP - 757 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Hoesch, I. A1 - Gerold, M. A1 - Hoesch, I. A1 - Ihle, Wolfgang A1 - Steigleider, Petra A1 - Stock, B. A1 - Stoehr, R.-M. A1 - Weindrich, D. A1 - Schmidt, Martin H. T1 - Behavioral Sequelae of Perinatal Insults and Early Family Adversity at 8 Years of Age Y1 - 2000 ER - TY - JOUR A1 - Fischer, Markus A1 - Dietz, H. A1 - Schmidt, B. T1 - Demographic and genetic invasion history of a 9-year-old roadside population of Bunias orientalis L. (Brassicaceae) Y1 - 1999 ER - TY - JOUR A1 - Wisotzki, Lutz A1 - Bacon, R. A1 - Brinchmann, J. A1 - Cantalupo, S. A1 - Richter, Philipp A1 - Schaye, J. A1 - Schmidt, Kasper Borello A1 - Urrutia, Tanya A1 - Weilbacher, Peter Michael A1 - Akhlaghi, M. A1 - Bouche, N. A1 - Contini, T. A1 - Guiderdoni, B. A1 - Herenz, E. C. A1 - Inami, H. A1 - Kerutt, Josephine Victoria A1 - Leclercq, F. A1 - Marino, R. A. A1 - Maseda, M. A1 - Monreal-Ibero, A. A1 - Nanayakkara, T. A1 - Richard, J. A1 - Saust, R. A1 - Steinmetz, Matthias A1 - Wendt, Martin T1 - Nearly all the sky is covered by Lyman-alpha emission around high-redshift galaxies JF - Nature : the international weekly journal of science N2 - Galaxies are surrounded by large reservoirs of gas, mostly hydrogen, that are fed by inflows from the intergalactic medium and by outflows from galactic winds. Absorption-line measurements along the lines of sight to bright and rare background quasars indicate that this circumgalactic medium extends far beyond the starlight seen in galaxies, but very little is known about its spatial distribution. The Lyman-alpha transition of atomic hydrogen at a wavelength of 121.6 nanometres is an important tracer of warm (about 104 kelvin) gas in and around galaxies, especially at cosmological redshifts greater than about 1.6 at which the spectral line becomes observable from the ground. Tracing cosmic hydrogen through its Lyman-a emission has been a long-standing goal of observational astrophysics(1-3), but the extremely low surface brightness of the spatially extended emission is a formidable obstacle. A new window into circumgalactic environments was recently opened by the discovery of ubiquitous extended Lyman-alpha emission from hydrogen around high-redshift galaxies(4,5). Such measurements were previously limited to especially favourable systems(6-8) or to the use of massive statistical averaging(9,10) because of the faintness of this emission. Here we report observations of low-surface-brightness Lyman-alpha emission surrounding faint galaxies at redshifts between 3 and 6. We find that the projected sky coverage approaches 100 per cent. The corresponding rate of incidence (the mean number of Lyman-alpha emitters penetrated by any arbitrary line of sight) is well above unity and similar to the incidence rate of high-column-density absorbers frequently detected in the spectra of distant quasars(11-14). This similarity suggests that most circumgalactic atomic hydrogen at these redshifts has now been detected in emission. Y1 - 2018 U6 - https://doi.org/10.1038/s41586-018-0564-6 SN - 0028-0836 SN - 1476-4687 VL - 562 IS - 7726 SP - 229 EP - 232 PB - Nature Publ. Group CY - London ER - TY - CHAP A1 - Patuchova, Nadezda B. A1 - Klein, Eckart A1 - Franzke, Jochen A1 - Büchner, Christiane A1 - Doroshenko, Egor N. A1 - Hoof, Karsten A1 - Zenin, Sergey S. A1 - Thiele, Carmen A1 - Schmidt, Carmen A1 - Fadeev, Vladimir Ivanovič A1 - Dombert, Matthias A1 - Sadovnikova, Galina D. A1 - Schulze, Carola A1 - Luchterhandt, Otto A1 - Syuzyukina, Oxana ED - Fadeev, Vladimir Ivanovič ED - Schulze, Carola T1 - Verfassungsentwicklung in Russland und Deutschland : Materialien des russisch-deutschen Symposiums anlässlich des 20. Jahrestages der Verfassung der Russischen Föderation am 25. und 26. September 2013 an der Universität Potsdam T1 - Progress of constitutions in Russia and in Germany N2 - Der Band enthält die Tagungsmaterialien des deutsch-russichen Symposiums zum Thema "Verfassungsentwicklung in Russland und Deutschland", welches am 25. und 26. September 2013 in Potsdam stattfand. Die Tagung wurde anlässlich des 20. Jahrestages der russischen Verfassung vom Dezember 2013 durchgeführt. Die inhaltlichen Schwerpunkte bilden die Themen: Verfassungsentstehung, Verfassungsänderung, Verfassungsprinzipien, Landesverfassungen, Fortentwicklung der Verfassung durch die Verfassungsgerichtsbarkeit und Grundrechte, die jeweils aus russischer und deutscher Sicht behandelt werden. Ergänzend befasst sich jeweils ein Betrag mit aktuellen Problemen der Menschenrechtsverwirklichung in Russland und der Ausländerintegration in Deutschland und Russland im Vergleich. KW - Verfassungsentstehung und -änderung KW - Verfassungsprinzipien KW - Verfassungsgerichtsbarkeit KW - Landesverfassung KW - Grundrechte KW - Integration Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70418 SN - 978-3-86956-289-6 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - van Rees, Charles B. A1 - Waylen, Kerry A. A1 - Schmidt-Kloiber, Astrid A1 - Thackeray, Stephen J. A1 - Kalinkat, Gregor A1 - Martens, Koen A1 - Domisch, Sami A1 - Lillebo, Ana A1 - Hermoso, Virgilio A1 - Grossart, Hans-Peter A1 - Schinegger, Rafaela A1 - Decleer, Kris A1 - Adriaens, Tim A1 - Denys, Luc A1 - Jaric, Ivan A1 - Janse, Jan H. A1 - Monaghan, Michael T. A1 - De Wever, Aaike A1 - Geijzendorffer, Ilse A1 - Adamescu, Mihai C. A1 - Jähnig, Sonja C. T1 - Safeguarding freshwater life beyond 2020 BT - recommendations for the new global biodiversity framework from the European experience JF - Conservation letters N2 - Plans are currently being drafted for the next decade of action on biodiversity-both the post-2020 Global Biodiversity Framework of the Convention on Biological Diversity (CBD) and Biodiversity Strategy of the European Union (EU). Freshwater biodiversity is disproportionately threatened and underprioritized relative to the marine and terrestrial biota, despite supporting a richness of species and ecosystems with their own intrinsic value and providing multiple essential ecosystem services. Future policies and strategies must have a greater focus on the unique ecology of freshwater life and its multiple threats, and now is a critical time to reflect on how this may be achieved. We identify priority topics including environmental flows, water quality, invasive species, integrated water resources management, strategic conservation planning, and emerging technologies for freshwater ecosystem monitoring. We synthesize these topics with decades of first-hand experience and recent literature into 14 special recommendations for global freshwater biodiversity conservation based on the successes and setbacks of European policy, management, and research. Applying and following these recommendations will inform and enhance the ability of global and European post-2020 biodiversity agreements to halt and reverse the rapid global decline of freshwater biodiversity. KW - climate change KW - conservation KW - ecosystem services KW - rivers KW - sustainable KW - development goals KW - water resources KW - wetlands Y1 - 2020 U6 - https://doi.org/10.1111/conl.12771 SN - 1755-263X VL - 14 IS - 1 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Spallanzani, Roberta A1 - Koga, Kenneth T. A1 - Cichy, Sarah B. A1 - Wiedenbeck, Michael A1 - Schmidt, Burkhard C. A1 - Oelze, Marcus A1 - Wilke, Max T1 - Lithium and boron diffusivity and isotopic fractionation in hydrated rhyolitic melts JF - Contributions to mineralogy and petrology N2 - Lithium and boron are trace components of magmas, released during exsolution of a gas phase during volcanic activity. In this study, we determine the diffusivity and isotopic fractionation of Li and B in hydrous silicate melts. Two glasses were synthesized with the same rhyolitic composition (4.2 wt% water), having different Li and B contents; these were studied in diffusion-couple experiments that were performed using an internally heated pressure vessel, operated at 300 MPa in the temperature range 700-1250 degrees C for durations from 0 s to 24 h. From this we determined activation energies for Li and B diffusion of 57 +/- 4 kJ/mol and 152 +/- 15 kJ/mol with pre-exponential factors of 1.53 x 10(-7) m(2)/s and 3.80 x 10(-8) m(2)/s, respectively. Lithium isotopic fractionation during diffusion gave beta values between 0.15 and 0.20, whereas B showed no clear isotopic fractionation. Our Li diffusivities and isotopic fractionation results differ somewhat from earlier published values, but overall confirm that Li diffusivity increases with water content. Our results on B diffusion show that similarly to Li, B mobility increases in the presence of water. By applying the Eyring relation, we confirm that B diffusivity is limited by viscous flow in silicate melts. Our results on Li and B diffusion present a new tool for understanding degassing-related processes, offering a potential geospeedometer to measure volcanic ascent rates. KW - stable isotopes KW - diffusion KW - isotopic fractionation KW - hydrated silicate KW - melts Y1 - 2022 U6 - https://doi.org/10.1007/s00410-022-01937-2 SN - 0010-7999 SN - 1432-0967 VL - 177 IS - 8 PB - Springer CY - New York ER - TY - JOUR A1 - Farges, Francois A1 - Djanarthany, S A1 - de Wispelaere, S A1 - Munoz, Manuel A1 - Magassouba, B A1 - Haddi, A A1 - Wilke, Max A1 - Schmidt, C. A1 - Borchert, Manuela A1 - Trocellier, P A1 - Crichton, W A1 - Simionovici, Alexandre A1 - Petit, Pierre-Emanuel A1 - Mezouar, Mohamed A1 - Etcheverry, M. P. A1 - Pallot-Frossard, I A1 - Bargar, John Reeder A1 - Brown, G. E. A1 - Grolimund, D A1 - Scheidegger, A T1 - Water in silicate glasses and melts of environmental interest : from volcanoes to cathedrals N2 - In silicate glasses and melts, water acts according to two main processes. First, it can be dissolved in high temperature/high pressure melts. Second, it constitutes a weathering agent on the glass surface. A number of in-situ x- ray absorption fine structure (XAFS) studies for Fe, Ni, Zr, Th and U show that the more charged cations (Zr, Nb, Mo, Ta, Sn, Th and U) are little affected by the presence of dissolved water in the melt. In contrast, divalent iron and nickel are highly sensitive to the presence of water, which enhance nucleation processes, for example, of phyllosilicates at the angstrom-scale. Such information provides additional constraints on the role of water deep in the Earth, particularly in magmatology. By contrast, the weathering of glass surfaces by water can be studied from a durability perspective. Experimental weathering experiments Of nuclear waste glasses performed in the laboratory show a variety of surface enrichments (carbon, chlorine, alkalis, iron) after exposure to atmospheric fluids and moisture. Mn-, and Fe-surface enrichments of analogous glasses of the XIVth century are related to the formation of Mn and Fe oxy/ hydroxides on the surface. The impact on the glass darkening is considered in terms of urban pollution and mass tourism Y1 - 2005 ER -