TY - JOUR A1 - Schäfer, Roland T1 - Rekommunalisierung - Fallstricke in der Praxis BT - Erfahrungen aus Bergkamen JF - KWI-Schriften N2 - Inhalt: I. Ausgangslage II. Aktuelle Entwicklungen III. Ursachen des Trends zur Rekommunalisierung IV. Praktische Erfahrungen aus Bergkamen V. Privatvergabe oder Kommunalerledigung? 1. Typische Fehler bei Entscheidungen zur Rekommunalisierung 2. Anregungen zur Vorgehensweise VI. Fazit Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62263 SN - 1867-951X SN - 1867-9528 IS - 6 SP - 73 EP - 80 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Döge, Nadine A1 - Hönzke, Stefan A1 - Schumacher, Fabian A1 - Balzus, Benjamin A1 - Colombo, Miriam A1 - Hadam, Sabrina A1 - Rancan, Fiorenza A1 - Blume-Peytavi, Ulrike A1 - Schäfer-Korting, Monika A1 - Schindler, Anke A1 - Rühl, Eckart A1 - Skov, Per Stahl A1 - Church, Martin K. A1 - Hedtrich, Sarah A1 - Kleuser, Burkhard A1 - Bodmeier, Roland A1 - Vogt, Annika T1 - Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers JF - Journal of controlled release N2 - Understanding penetration not only in intact, but also in lesional skin with impaired skin barrier function is important, in order to explore the surplus value of nanoparticle-based drug delivery for anti-inflammatory dermatotherapy. Herein, short-termex vivo cultures of (i) intact human skin, (ii) skin pretreated with tape-strippings and (iii) skin pre-exposed to sodium lauryl sulfate (SLS) were used to assess the penetration of dexamethasone (Dex). Intradermal microdialysis was utilized for up to 24 h after drug application as commercial cream, nanocrystals or ethyl cellulose nanocarriers applied at the therapeutic concentration of 0.05%, respectively. In addition, Dex was assessed in culture media and extracts from stratum corneum, epidermis and dermis after 24 h, and the results were compared to those in heat-separated split skin from studies in Franz diffusion cells. Providing fast drug release, nanocrystals significantly accelerated the penetration of Dex. In contrast to the application of cream and ethyl cellulose nanocarriers, Dex was already detectable in eluates after 6 h when applying nanocrystals on intact skin. Disruption of the skin barrier further accelerated and enhanced the penetration. Encapsulation in ethyl cellulose nanocarriers delayed Dex penetration. Interestingly, for all formulations highly increased concentrations in the dialysate were observed in tape-stripped skin, whereas the extent of enhancement was less in SLS-exposed skin. The results were confirmed in tissue extracts and were in line with the predictions made by in vitro release studies and ex vivo Franz diffusion cell experiments. The use of 45 kDa probes further enabled the collection of inflammatory cytokines. However, the estimation of glucocorticoid efficacy by Interleukin (IL)-6 and IL-8 analysis was limited due to the trauma induced by the probe insertion. Ex vivo intradermal microdialysis combined with culture media analysis provides an effective, skin-sparing method for preclinical assessment of novel drug delivery systems at therapeutic doses in models of diseased skin. (C) 2016 Elsevier B.V. All rights reserved. KW - Drug delivery systems KW - Polymeric nanoparticles KW - Dexamethasone KW - Microdialysis KW - Skin penetration KW - Skin barrier disruption Y1 - 2016 U6 - https://doi.org/10.1016/j.jconrel.2016.07.009 SN - 0168-3659 SN - 1873-4995 VL - 242 SP - 25 EP - 34 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Bauer, Hartmut A1 - Mühl-Jäckel, Margarete A1 - Becker, Ulrich A1 - Brüning, Christoph A1 - Schäfer, Roland A1 - Röber, Manfred A1 - Kunze, Sebastian ED - Bauer, Hartmut ED - Büchner, Christiane ED - Hajasch, Lydia T1 - Rekommunalisierung öffentlicher Daseinsvorsorge N2 - Mehr Privat statt Staat! Diese Kampfformel galt vielen noch vor kurzem als Schlüssel zur erfolgreichen Entlastung der angespannten kommunalen Haushalte. Immer mehr Kommunen beschritten den vermeintlichen Königsweg. So vielfältig wie die Gegenstände sind auch die in der Verwaltungspraxis zu beobachtenden Erscheinungsformen der Privatisierung: Vermögensprivatisierung, Organisationsprivatisierung, Aufgabenprivatisierung mit facettenreichen Mischformen namentlich der Public Private Partnerships. Zwar brachte der „Verkauf des Tafelsilbers“ den Kommunen kurzzeitig einen Geldsegen. Doch haben bei weitem nicht alle Privatisierungsmaßnahmen die in sie gesetzten Erwartungen erfüllt und es setzt sich zunehmend die Einsicht durch, dass die Privatwirtschaft nicht zwangsläufig besser, effizienter und kostengünstiger arbeitet als die Öffentliche Hand. Inzwischen deutet sich im kommunalen Bereich eine klare Trendumkehr in Richtung Rekommunalisierung an. Die 17. Fachtagung des Kommunalwissenschaftlichen Instituts (KWI) der Universität Potsdam greift in diese anlaufende Grundsatzdebatte ein und nimmt aktuelle Bestrebungen der Rekommunalisierung lokaler Aufgaben auf. Im Vordergrund stehen erste praktische Erfahrungen, Implementationsprobleme und nicht zuletzt die rechtlichen Rahmenbedingungen und normativen Direktiven für Rekommunalisierungen namentlich in Segmenten der öffentlichen Daseinsvorsorge. N2 - "Private-run better than state-run." Up until a short while ago this had been the battle slogan for a successful discharge of the tight municipal budgets. More and more municipalities chose this supposedly ideal solution. As diverse as the subjects of privatisation are, are its forms to be seen in administrative practice: privatising of property owned by public authorities, of organisations and of responsibilities with various mixed forms specially the Public Private Partnerships. The selling of significant municipal property brought a short welcome sum to the local governments. But by far not all of privatising measures fulfilled expectations and it is increasingly realised that private sector is working neither better, nor more efficiently, nor less expensively than public authorities. Meanwhile a trend towards remunicipalisation is clearly observed in municipal sector. The 17th Congress of the Institute of Local Government Studies of the University of Potsdam (KWI) interferes in this debate on fundamental principles and takes up actual efforts of remunicipalisation. Here, first practical experiences, problems of implementation and last but not least legal basic conditions and normative directives for remunicipalisation specially in parts of the general public service are most important. T3 - KWI-Schriften - 6 KW - Rekommunalisierung KW - öffentliche Daseinsvorsorge KW - Kommunalwirtschaft KW - Privatisierung KW - Konzessionsverträge Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-58064 SN - 978-3-86956-170-7 SN - 1867-9528 SN - 1867-951X PB - Universitätsvlerag Potsdam CY - Potsdam ER -