TY - INPR A1 - Acharya, B. S. A1 - Actis, M. A1 - Aghajani, T. A1 - Agnetta, G. A1 - Aguilar, J. A1 - Aharonian, Felix A. A1 - Ajello, M. A1 - Akhperjanian, A. G. A1 - Alcubierre, M. A1 - Aleksic, J. A1 - Alfaro, R. A1 - Aliu, E. A1 - Allafort, A. J. A1 - Allan, D. A1 - Allekotte, I. A1 - Amato, E. A1 - Anderson, J. A1 - Angüner, Ekrem Oǧuzhan A1 - Antonelli, L. A. A1 - Antoranz, P. A1 - Aravantinos, A. A1 - Arlen, T. A1 - Armstrong, T. A1 - Arnaldi, H. A1 - Arrabito, L. A1 - Asano, K. A1 - Ashton, T. A1 - Asorey, H. G. A1 - Awane, Y. A1 - Baba, H. A1 - Babic, A. A1 - Baby, N. A1 - Baehr, J. A1 - Bais, A. A1 - Baixeras, C. A1 - Bajtlik, S. A1 - Balbo, M. A1 - Balis, D. A1 - Balkowski, C. A1 - Bamba, A. A1 - Bandiera, R. A1 - Barber, A. A1 - Barbier, C. A1 - Barcelo, M. A1 - Barnacka, Anna A1 - Barnstedt, Jürgen A1 - Barres de Almeida, U. A1 - Barrio, J. A. A1 - Basili, A. A1 - Basso, S. A1 - Bastieri, D. A1 - Bauer, C. A1 - Baushev, Anton N. A1 - Becerra Gonzalez, J. A1 - Becherini, Yvonne A1 - Bechtol, K. C. A1 - Tjus, J. Becker A1 - Beckmann, Volker A1 - Bednarek, W. A1 - Behera, B. A1 - Belluso, M. A1 - Benbow, W. A1 - Berdugo, J. A1 - Berger, K. A1 - Bernard, F. A1 - Bernardino, T. A1 - Bernlöhr, K. A1 - Bhat, N. A1 - Bhattacharyya, S. A1 - Bigongiari, C. A1 - Biland, A. A1 - Billotta, S. A1 - Bird, T. A1 - Birsin, E. A1 - Bissaldi, E. A1 - Biteau, Jonathan A1 - Bitossi, M. A1 - Blake, S. A1 - Blanch Bigas, O. A1 - Blasi, P. A1 - Bobkov, A. A. A1 - Boccone, V. A1 - Boettcher, Markus A1 - Bogacz, L. A1 - Bogart, J. A1 - Bogdan, M. A1 - Boisson, Catherine A1 - Boix Gargallo, J. A1 - Bolmont, J. A1 - Bonanno, G. A1 - Bonardi, A. A1 - Bonev, T. A1 - Bonifacio, P. A1 - Bonnoli, G. A1 - Bordas, Pol A1 - Borgland, A. W. A1 - Borkowski, Janett A1 - Bose, R. A1 - Botner, O. A1 - Bottani, A. A1 - Bouchet, L. A1 - Bourgeat, M. A1 - Boutonnet, C. A1 - Bouvier, A. A1 - Brau-Nogue, S. A1 - Braun, I. A1 - Bretz, T. A1 - Briggs, M. S. A1 - Bringmann, T. A1 - Brook, P. A1 - Brun, Pierre A1 - Brunetti, L. A1 - Buanes, T. A1 - Buckley, J. H. A1 - Buehler, R. A1 - Bugaev, V. A1 - Bulgarelli, A. A1 - Bulik, Tomasz A1 - Busetto, G. A1 - Buson, S. A1 - Byrum, K. A1 - Cailles, M. A1 - Cameron, R. A. A1 - Camprecios, J. A1 - Canestrari, R. A1 - Cantu, S. A1 - Capalbi, M. A1 - Caraveo, P. A. A1 - Carmona, E. A1 - Carosi, A. A1 - Carr, John A1 - Carton, P. H. A1 - Casanova, Sabrina A1 - Casiraghi, M. A1 - Catalano, O. A1 - Cavazzani, S. A1 - Cazaux, S. A1 - Cerruti, M. A1 - Chabanne, E. A1 - Chadwick, Paula M. A1 - Champion, C. A1 - Chen, Andrew A1 - Chiang, J. A1 - Chiappetti, L. A1 - Chikawa, M. A1 - Chitnis, V. R. A1 - Chollet, F. A1 - Chudoba, J. A1 - Cieslar, M. A1 - Cillis, A. N. A1 - Cohen-Tanugi, J. A1 - Colafrancesco, Sergio A1 - Colin, P. A1 - Calome, J. A1 - Colonges, S. A1 - Compin, M. A1 - Conconi, P. A1 - Conforti, V. A1 - Connaughton, V. A1 - Conrad, Jan A1 - Contreras, J. L. A1 - Coppi, P. A1 - Corona, P. A1 - Corti, D. A1 - Cortina, J. A1 - Cossio, L. A1 - Costantini, H. A1 - Cotter, G. A1 - Courty, B. A1 - Couturier, S. A1 - Covino, S. A1 - Crimi, G. A1 - Criswell, S. J. A1 - Croston, J. A1 - Cusumano, G. A1 - Dafonseca, M. A1 - Dale, O. A1 - Daniel, M. A1 - Darling, J. A1 - Davids, I. A1 - Dazzi, F. A1 - De Angelis, A. A1 - De Caprio, V. A1 - De Frondat, F. A1 - de Gouveia Dal Pino, E. M. A1 - de la Calle, I. A1 - De La Vega, G. A. A1 - Lopez, R. de los Reyes A1 - De Lotto, B. A1 - De Luca, A. A1 - de Mello Neto, J. R. T. A1 - de Naurois, M. A1 - de Oliveira, Y. A1 - de Ona Wilhelmi, E. A1 - de Souza, V. A1 - Decerprit, G. A1 - Decock, G. A1 - Deil, C. A1 - Delagnes, E. A1 - Deleglise, G. A1 - Delgado, C. A1 - Della Volpe, D. A1 - Demange, P. A1 - Depaola, G. A1 - Dettlaff, A. A1 - Di Paola, A. A1 - Di Pierro, F. A1 - Diaz, C. A1 - Dick, J. A1 - Dickherber, R. A1 - Dickinson, H. A1 - Diez-Blanco, V. A1 - Digel, S. A1 - Dimitrov, D. A1 - Disset, G. A1 - Djannati-Ataï, A. A1 - Doert, M. A1 - Dohmke, M. A1 - Domainko, W. A1 - Prester, Dijana Dominis A1 - Donat, A. A1 - Dorner, D. A1 - Doro, M. A1 - Dournaux, J-L. A1 - Drake, G. A1 - Dravins, D. A1 - Drury, L. A1 - Dubois, F. A1 - Dubois, R. A1 - Dubus, G. A1 - Dufour, C. A1 - Dumas, D. A1 - Dumm, J. A1 - Durand, D. A1 - Dyks, J. A1 - Dyrda, M. A1 - Ebr, J. A1 - Edy, E. A1 - Egberts, Kathrin A1 - Eger, P. A1 - Einecke, S. A1 - Eleftheriadis, C. A1 - Elles, S. A1 - Emmanoulopoulos, D. A1 - Engelhaupt, D. A1 - Enomoto, R. A1 - Ernenwein, J-P A1 - Errando, M. A1 - Etchegoyen, A. A1 - Evans, P. A1 - Falcone, A. A1 - Fantinel, D. A1 - Farakos, K. A1 - Farnier, C. A1 - Fasola, G. A1 - Favill, B. A1 - Fede, E. A1 - Federici, S. A1 - Fegan, S. A1 - Feinstein, F. A1 - Ferenc, D. A1 - Ferrando, P. A1 - Fesquet, M. A1 - Fiasson, A. A1 - Fillin-Martino, E. A1 - Fink, D. A1 - Finley, C. A1 - Finley, J. P. A1 - Fiorini, M. A1 - Firpo Curcoll, R. A1 - Flores, H. A1 - Florin, D. A1 - Focke, W. A1 - Foehr, C. A1 - Fokitis, E. A1 - Font, L. A1 - Fontaine, G. A1 - Fornasa, M. A1 - Foerster, A. A1 - Fortson, L. A1 - Fouque, N. A1 - Franckowiak, A. A1 - Fransson, C. A1 - Fraser, G. A1 - Frei, R. A1 - Albuquerque, I. F. M. A1 - Fresnillo, L. A1 - Fruck, C. A1 - Fujita, Y. A1 - Fukazawa, Y. A1 - Fukui, Y. A1 - Funk, S. A1 - Gaebele, W. A1 - Gabici, S. A1 - Gabriele, R. A1 - Gadola, A. A1 - Galante, N. A1 - Gall, D. A1 - Gallant, Y. A1 - Gamez-Garcia, J. A1 - Garcia, B. A1 - Garcia Lopez, R. A1 - Gardiol, D. A1 - Garrido, D. A1 - Garrido, L. A1 - Gascon, D. A1 - Gaug, M. A1 - Gaweda, J. A1 - Gebremedhin, L. A1 - Geffroy, N. A1 - Gerard, L. A1 - Ghedina, A. A1 - Ghigo, M. A1 - Giannakaki, E. A1 - Gianotti, F. A1 - Giarrusso, S. A1 - Giavitto, G. A1 - Giebels, B. A1 - Gika, V. A1 - Giommi, P. A1 - Girard, N. A1 - Giro, E. A1 - Giuliani, A. A1 - Glanzman, T. A1 - Glicenstein, J. -F. A1 - Godinovic, N. A1 - Golev, V. A1 - Gomez Berisso, M. A1 - Gomez-Ortega, J. A1 - Gonzalez, M. M. A1 - Gonzalez, A. A1 - Gonzalez, F. A1 - Gonzalez Munoz, A. A1 - Gothe, K. S. A1 - Gougerot, M. A1 - Graciani, R. A1 - Grandi, P. A1 - Granena, F. A1 - Granot, J. A1 - Grasseau, G. A1 - Gredig, R. A1 - Green, A. A1 - Greenshaw, T. A1 - Gregoire, T. A1 - Grimm, O. A1 - Grube, J. A1 - Grudzinska, M. A1 - Gruev, V. A1 - Gruenewald, S. A1 - Grygorczuk, J. A1 - Guarino, V. A1 - Gunji, S. A1 - Gyuk, G. A1 - Hadasch, D. A1 - Hagiwara, R. A1 - Hahn, J. A1 - Hakansson, N. A1 - Hallgren, A. A1 - Hamer Heras, N. A1 - Hara, S. A1 - Hardcastle, M. J. A1 - Harris, J. A1 - Hassan, T. A1 - Hatanaka, K. A1 - Haubold, T. A1 - Haupt, A. A1 - Hayakawa, T. A1 - Hayashida, M. A1 - Heller, R. A1 - Henault, F. A1 - Henri, G. A1 - Hermann, G. A1 - Hermel, R. A1 - Herrero, A. A1 - Hidaka, N. A1 - Hinton, J. A1 - Hoffmann, D. A1 - Hofmann, W. A1 - Hofverberg, P. A1 - Holder, J. A1 - Horns, D. A1 - Horville, D. A1 - Houles, J. A1 - Hrabovsky, M. A1 - Hrupec, D. A1 - Huan, H. A1 - Huber, B. A1 - Huet, J. -M. A1 - Hughes, G. A1 - Humensky, T. B. A1 - Huovelin, J. A1 - Ibarra, A. A1 - Illa, J. M. A1 - Impiombato, D. A1 - Incorvaia, S. A1 - Inoue, S. A1 - Inoue, Y. A1 - Ioka, K. A1 - Ismailova, E. A1 - Jablonski, C. A1 - Jacholkowska, A. A1 - Jamrozy, M. A1 - Janiak, M. A1 - Jean, P. A1 - Jeanney, C. A1 - Jimenez, J. J. A1 - Jogler, T. A1 - Johnson, T. A1 - Journet, L. A1 - Juffroy, C. A1 - Jung, I. A1 - Kaaret, P. A1 - Kabuki, S. A1 - Kagaya, M. A1 - Kakuwa, J. A1 - Kalkuhl, C. A1 - Kankanyan, R. A1 - Karastergiou, A. A1 - Kaercher, K. A1 - Karczewski, M. A1 - Karkar, S. A1 - Kasperek, Aci. A1 - Kastana, D. A1 - Katagiri, H. A1 - Kataoka, J. A1 - Katarzynski, K. A1 - Katz, U. A1 - Kawanaka, N. A1 - Kellner-Leidel, B. A1 - Kelly, H. A1 - Kendziorra, E. A1 - Khelifi, B. A1 - Kieda, D. B. A1 - Kifune, T. A1 - Kihm, T. A1 - Kishimoto, T. A1 - Kitamoto, K. A1 - Kluzniak, W. A1 - Knapic, C. A1 - Knapp, J. w A1 - Knoedlseder, J. A1 - Koeck, F. A1 - Kocot, J. A1 - Kodani, K. A1 - Koehne, J. -H. A1 - Kohri, K. A1 - Kokkotas, K. A1 - Kolitzus, D. A1 - Komin, N. A1 - Kominis, I. A1 - Konno, Y. A1 - Koeppel, H. A1 - Korohoda, P. A1 - Kosack, K. A1 - Koss, G. A1 - Kossakowski, R. A1 - Kostka, P. A1 - Koul, R. A1 - Kowal, G. A1 - Koyama, S. A1 - Koziol, J. A1 - Kraehenbuehl, T. A1 - Krause, J. A1 - Krawzcynski, H. A1 - Krennrich, F. A1 - Krepps, A. A1 - Kretzschmann, A. A1 - Krobot, R. A1 - Krueger, P. A1 - Kubo, H. A1 - Kudryavtsev, V. A. A1 - Kushida, J. A1 - Kuznetsov, A. A1 - La Barbera, A. A1 - La Palombara, N. A1 - La Parola, V. A1 - La Rosa, G. A1 - Lacombe, K. A1 - Lamanna, G. A1 - Lande, J. A1 - Languignon, D. A1 - Lapington, J. A1 - Laporte, P. A1 - Lavalley, C. A1 - Le Flour, T. A1 - Le Padellec, A. A1 - Lee, S. -H. A1 - Lee, W. H. A1 - Leigui de Oliveira, M. A. A1 - Lelas, D. A1 - Lenain, J. -P. A1 - Leopold, D. J. A1 - Lerch, T. A1 - Lessio, L. A1 - Lieunard, B. A1 - Lindfors, E. A1 - Liolios, A. A1 - Lipniacka, A. A1 - Lockart, H. A1 - Lohse, T. A1 - Lombardi, S. A1 - Lopatin, A. A1 - Lopez, M. A1 - Lopez-Coto, R. A1 - Lopez-Oramas, A. A1 - Lorca, A. A1 - Lorenz, E. A1 - Lubinski, P. A1 - Lucarelli, F. A1 - Luedecke, H. A1 - Ludwin, J. A1 - Luque-Escamilla, P. L. A1 - Lustermann, W. A1 - Luz, O. A1 - Lyard, E. A1 - Maccarone, M. C. A1 - Maccarone, T. J. A1 - Madejski, G. M. A1 - Madhavan, A. A1 - Mahabir, M. A1 - Maier, G. A1 - Majumdar, P. A1 - Malaguti, G. A1 - Maltezos, S. A1 - Manalaysay, A. A1 - Mancilla, A. A1 - Mandat, D. A1 - Maneva, G. A1 - Mangano, A. A1 - Manigot, P. A1 - Mannheim, K. A1 - Manthos, I. A1 - Maragos, N. A1 - Marcowith, Alexandre A1 - Mariotti, M. A1 - Marisaldi, M. A1 - Markoff, S. A1 - Marszalek, A. A1 - Martens, C. A1 - Marti, J. A1 - Martin, J-M. A1 - Martin, P. A1 - Martinez, G. A1 - Martinez, F. A1 - Martinez, M. A1 - Masserot, A. A1 - Mastichiadis, A. A1 - Mathieu, A. A1 - Matsumoto, H. A1 - Mattana, F. A1 - Mattiazzo, S. A1 - Maurin, G. A1 - Maxfield, S. A1 - Maya, J. A1 - Mazin, D. A1 - Mc Comb, L. A1 - McCubbin, N. A1 - McHardy, I. A1 - McKay, R. A1 - Medina, C. A1 - Melioli, C. A1 - Melkumyan, D. A1 - Mereghetti, S. A1 - Mertsch, P. A1 - Meucci, M. A1 - Michalowski, J. A1 - Micolon, P. A1 - Mihailidis, A. A1 - Mineo, T. A1 - Minuti, M. A1 - Mirabal, N. A1 - Mirabel, F. A1 - Miranda, J. M. A1 - Mirzoyan, R. A1 - Mizuno, T. A1 - Moal, B. A1 - Moderski, R. A1 - Mognet, I. A1 - Molinari, E. A1 - Molinaro, M. A1 - Montaruli, T. A1 - Monteiro, I. A1 - Moore, P. A1 - Moralejo Olaizola, A. A1 - Mordalska, M. A1 - Morello, C. A1 - Mori, K. A1 - Mottez, F. A1 - Moudden, Y. A1 - Moulin, Emmanuel A1 - Mrusek, I. A1 - Mukherjee, R. A1 - Munar-Adrover, P. A1 - Muraishi, H. A1 - Murase, K. A1 - Murphy, A. A1 - Nagataki, S. A1 - Naito, T. A1 - Nakajima, D. A1 - Nakamori, T. A1 - Nakayama, K. A1 - Naumann, C. L. A1 - Naumann, D. A1 - Naumann-Godo, M. A1 - Nayman, P. A1 - Nedbal, D. A1 - Neise, D. A1 - Nellen, L. A1 - Neustroev, V. A1 - Neyroud, N. A1 - Nicastro, L. A1 - Nicolau-Kuklinski, J. A1 - Niedzwiecki, A. A1 - Niemiec, J. A1 - Nieto, D. A1 - Nikolaidis, A. A1 - Nishijima, K. A1 - Nolan, S. A1 - Northrop, R. A1 - Nosek, D. A1 - Nowak, N. A1 - Nozato, A. A1 - O'Brien, P. A1 - Ohira, Y. A1 - Ohishi, M. A1 - Ohm, S. A1 - Ohoka, H. A1 - Okuda, T. A1 - Okumura, A. A1 - Olive, J. -F. A1 - Ong, R. A. A1 - Orito, R. A1 - Orr, M. A1 - Osborne, J. A1 - Ostrowski, M. A1 - Otero, L. A. A1 - Otte, N. A1 - Ovcharov, E. A1 - Oya, I. A1 - Ozieblo, A. A1 - Padilla, L. A1 - Paiano, S. A1 - Paillot, D. A1 - Paizis, A. A1 - Palanque, S. A1 - Palatka, M. A1 - Pallota, J. A1 - Panagiotidis, K. A1 - Panazol, J. -L. A1 - Paneque, D. A1 - Panter, M. A1 - Paoletti, R. A1 - Papayannis, Alexandros A1 - Papyan, G. A1 - Paredes, J. M. A1 - Pareschi, G. A1 - Parks, G. A1 - Parraud, J. -M. A1 - Parsons, D. A1 - Arribas, M. Paz A1 - Pech, M. A1 - Pedaletti, G. A1 - Pelassa, V. A1 - Pelat, D. A1 - Perez, M. D. C. A1 - Persic, M. A1 - Petrucci, P-O A1 - Peyaud, B. A1 - Pichel, A. A1 - Pita, S. A1 - Pizzolato, F. A1 - Platos, L. A1 - Platzer, R. A1 - Pogosyan, L. A1 - Pohl, M. A1 - Pojmanski, G. A1 - Ponz, J. D. A1 - Potter, W. A1 - Poutanen, J. A1 - Prandini, E. A1 - Prast, J. A1 - Preece, R. A1 - Profeti, F. A1 - Prokoph, H. A1 - Prouza, M. A1 - Proyetti, M. A1 - Puerto-Gimenez, I. A1 - Puehlhofer, G. A1 - Puljak, I. A1 - Punch, M. A1 - Pyziol, R. A1 - Quel, E. J. A1 - Quinn, J. A1 - Quirrenbach, A. A1 - Racero, E. A1 - Rajda, P. J. A1 - Ramon, P. A1 - Rando, R. A1 - Rannot, R. C. A1 - Rataj, M. A1 - Raue, M. A1 - Reardon, P. A1 - Reimann, O. A1 - Reimer, A. A1 - Reimer, O. A1 - Reitberger, K. A1 - Renaud, M. A1 - Renner, S. A1 - Reville, B. A1 - Rhode, W. A1 - Ribo, M. A1 - Ribordy, M. A1 - Richer, M. G. A1 - Rico, J. A1 - Ridky, J. A1 - Rieger, F. A1 - Ringegni, P. A1 - Ripken, J. A1 - Ristori, P. R. A1 - Riviere, A. A1 - Rivoire, S. A1 - Rob, L. A1 - Roeser, U. A1 - Rohlfs, R. A1 - Rojas, G. A1 - Romano, Patrizia A1 - Romaszkan, W. A1 - Romero, G. E. A1 - Rosen, S. A1 - Lees, S. Rosier A1 - Ross, D. A1 - Rouaix, G. A1 - Rousselle, J. A1 - Rousselle, S. A1 - Rovero, A. C. A1 - Roy, F. A1 - Royer, S. A1 - Rudak, B. A1 - Rulten, C. A1 - Rupinski, M. A1 - Russo, F. A1 - Ryde, F. A1 - Sacco, B. A1 - Saemann, E. O. A1 - Saggion, A. A1 - Safiakian, V. A1 - Saito, K. A1 - Saito, T. A1 - Saito, Y. A1 - Sakaki, N. A1 - Sakonaka, R. A1 - Salini, A. A1 - Sanchez, F. A1 - Sanchez-Conde, M. A1 - Sandoval, A. A1 - Sandaker, H. A1 - Sant'Ambrogio, E. A1 - Santangelo, A. A1 - Santos, E. M. A1 - Sanuy, A. A1 - Sapozhnikov, L. A1 - Sarkar, S. A1 - Sartore, N. A1 - Sasaki, H. A1 - Satalecka, K. A1 - Sawada, M. A1 - Scalzotto, V. A1 - Scapin, V. A1 - Scarcioffolo, M. A1 - Schafer, J. A1 - Schanz, T. A1 - Schlenstedt, S. A1 - Schlickeiser, R. A1 - Schmidt, T. A1 - Schmoll, J. A1 - Schovanek, P. A1 - Schroedter, M. A1 - Schultz, C. A1 - Schultze, J. A1 - Schulz, A. A1 - Schure, K. A1 - Schwab, T. A1 - Schwanke, U. A1 - Schwarz, J. A1 - Schwarzburg, S. A1 - Schweizer, T. 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A1 - Yamamoto, T. A1 - Yamazaki, R. A1 - Yanagita, S. A1 - Yebras, J. M. A1 - Yelos, D. A1 - Yoshida, A. A1 - Yoshida, T. A1 - Yoshikoshi, T. A1 - Zabalza, V. A1 - Zacharias, M. A1 - Zajczyk, A. A1 - Zanin, R. A1 - Zdziarski, A. A1 - Zech, Alraune A1 - Zhao, A. A1 - Zhou, X. A1 - Zietara, K. A1 - Ziolkowski, J. A1 - Ziolkowski, P. A1 - Zitelli, V. A1 - Zurbach, C. A1 - Zychowski, P. T1 - Introducing the CTA concept T2 - Astroparticle physics N2 - The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. KW - TeV gamma-ray astronomy KW - Air showers KW - Cherenkov Telescopes Y1 - 2013 U6 - https://doi.org/10.1016/j.astropartphys.2013.01.007 SN - 0927-6505 SN - 1873-2852 VL - 43 IS - 2 SP - 3 EP - 18 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Actis, M. A1 - Agnetta, G. A1 - Aharonian, Felix A. A1 - Akhperjanian, A. G. A1 - Aleksic, J. A1 - Aliu, E. A1 - Allan, D. A1 - Allekotte, I. A1 - Antico, F. A1 - Antonelli, L. A. A1 - Antoranz, P. A1 - Aravantinos, A. A1 - Arlen, T. A1 - Arnaldi, H. A1 - Artmann, S. A1 - Asano, K. A1 - Asorey, H. G. A1 - Baehr, J. A1 - Bais, A. A1 - Baixeras, C. 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A1 - Tavernet, J. -P. A1 - Tchernin, C. A1 - Tejedor, L. A. A1 - Telezhinsky, Igor O. A1 - Temnikov, P. A1 - Tenzer, C. A1 - Terada, Y. A1 - Terrier, R. A1 - Teshima, M. A1 - Testa, V. A1 - Tibaldo, L. A1 - Tibolla, O. A1 - Tluczykont, M. A1 - Peixoto, C. J. Todero A1 - Tokanai, F. A1 - Tokarz, M. A1 - Toma, K. A1 - Torres, D. F. A1 - Tosti, G. A1 - Totani, T. A1 - Toussenel, F. A1 - Vallania, P. A1 - Vallejo, G. A1 - van der Walt, J. A1 - van Eldik, C. A1 - Vandenbroucke, J. A1 - Vankov, H. A1 - Vasileiadis, G. A1 - Vassiliev, V. V. A1 - Vegas, I. A1 - Venter, L. A1 - Vercellone, S. A1 - Veyssiere, C. A1 - Vialle, J. P. A1 - Videla, M. A1 - Vincent, P. A1 - Vink, J. A1 - Vlahakis, N. A1 - Vlahos, L. A1 - Vogler, P. A1 - Vollhardt, A. A1 - Volpe, F. A1 - Von Gunten, H. P. A1 - Vorobiov, S. A1 - Wagner, S. A1 - Wagner, R. M. A1 - Wagner, B. A1 - Wakely, S. P. A1 - Walter, P. A1 - Walter, R. A1 - Warwick, R. A1 - Wawer, P. A1 - Wawrzaszek, R. A1 - Webb, N. A1 - Wegner, P. A1 - Weinstein, A. A1 - Weitzel, Q. A1 - Welsing, R. A1 - Wetteskind, H. A1 - White, R. A1 - Wierzcholska, A. A1 - Wilkinson, M. I. A1 - Williams, D. A. A1 - Winde, M. A1 - Wischnewski, R. A1 - Wisniewski, L. A1 - Wolczko, A. A1 - Wood, M. A1 - Xiong, Q. A1 - Yamamoto, T. A1 - Yamaoka, K. A1 - Yamazaki, R. A1 - Yanagita, S. A1 - Yoffo, B. A1 - Yonetani, M. A1 - Yoshida, A. A1 - Yoshida, T. A1 - Yoshikoshi, T. A1 - Zabalza, V. A1 - Zagdanski, A. A1 - Zajczyk, A. A1 - Zdziarski, A. A1 - Zech, Alraune A1 - Zietara, K. A1 - Ziolkowski, P. A1 - Zitelli, V. A1 - Zychowski, P. T1 - Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy JF - Experimental astronomy : an international journal on astronomical instrumentation and data analysis N2 - Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA. KW - Ground based gamma ray astronomy KW - Next generation Cherenkov telescopes KW - Design concepts Y1 - 2011 U6 - https://doi.org/10.1007/s10686-011-9247-0 SN - 0922-6435 SN - 1572-9508 VL - 32 IS - 3 SP - 193 EP - 316 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Ellis, S. C. A1 - Bauer, S. A1 - Bacigalupo, C. A1 - Bland-Hawthorn, J. A1 - Bryant, J. J. A1 - Case, S. A1 - Content, R. A1 - Fechner, T. A1 - Giannone, D. A1 - Haynes, R. A1 - Hernandez, E. A1 - Horton, A. J. A1 - Klauser, U. A1 - Lawrence, J. S. A1 - Leon-Saval, S. G. A1 - Lindley, E. A1 - Löhmannsröben, Hans-Gerd A1 - Min, S. -S. A1 - Pai, N. A1 - Roth, M. A1 - Shortridge, K. A1 - Waller, L. A1 - Xavier, Pascal A1 - Zhelem, Ross T1 - PRAXIS: an OH suppression optimised near infrared spectrograph T2 - Ground-based and Airborne Instrumentation for Astronomy VII N2 - The problem of atmospheric emission from OH molecules is a long standing problem for near-infrared astronomy. PRAXIS is a unique spectrograph which is fed by fibres that remove the OH background and is optimised specifically to benefit from OH-Suppression. The OH suppression is achieved with fibre Bragg gratings, which were tested successfully on the GNOSIS instrument. PRAXIS uses the same fibre Bragg gratings as GNOSIS in its first implementation, and will exploit new, cheaper and more efficient, multicore fibre Bragg gratings in the second implementation. The OH lines are suppressed by a factor of similar to 1000, and the expected increase in the signal-to-noise in the interline regions compared to GNOSIS is a factor of similar to 9 with the GNOSIS gratings and a factor of similar to 17 with the new gratings. PRAXIS will enable the full exploitation of OH suppression for the first time, which was not achieved by GNOSIS (a retrofit to an existing instrument that was not OH-Suppression optimised) due to high thermal emission, low spectrograph transmission and detector noise. PRAXIS has extremely low thermal emission, through the cooling of all significantly emitting parts, including the fore-optics, the fibre Bragg gratings, a long length of fibre, and the fibre slit, and an optical design that minimises leaks of thermal emission from outside the spectrograph. PRAXIS has low detector noise through the use of a Hawaii-2RG detector, and a high throughput through a efficient VPH based spectrograph. PRAXIS will determine the absolute level of the interline continuum and enable observations of individual objects via an IFU. In this paper we give a status update and report on acceptance tests. KW - Near infrared KW - spectroscopy KW - OH suppression KW - astrophotonics KW - fibre Bragg gratings Y1 - 2018 SN - 978-1-5106-1958-6 U6 - https://doi.org/10.1117/12.2311898 SN - 0277-786X SN - 1996-756X VL - 10702 PB - SPIE-INT Soc Optical Engineering CY - Bellingham ER - TY - JOUR A1 - Stracke, A. A1 - Bayer, A. A1 - Zimmermann, S. A1 - Wendorff, Joachim Heinz A1 - Wirges, Werner A1 - Bauer-Gogonea, Simona A1 - Bauer, Siegfried A1 - Gerhard, Reimund T1 - Relaxation behaviour of electrically induced polar orientation and of optically induced non-polar orientation in an azo-chromophore side group polymer Y1 - 1999 SN - 0022-3727 ER - TY - JOUR A1 - Cheng, Z. Y. A1 - Katiyar, R. S. A1 - Bauer, Siegfried A1 - Bauer-Gogonea, Simona A1 - Gerhard, Reimund T1 - Thermally stimulated depolarization current of a nonlinear optical side-chain polymer Y1 - 1998 ER - TY - JOUR A1 - Rienks, Emile D. L. A1 - Wimmer, S. A1 - Sanchez-Barriga, Jaime A1 - Caha, O. A1 - Mandal, Partha Sarathi A1 - Ruzicka, J. A1 - Ney, A. A1 - Steiner, H. A1 - Volobuev, V. V. A1 - Groiss, H. A1 - Albu, M. A1 - Kothleitner, G. A1 - Michalicka, J. A1 - Khan, S. A. A1 - Minar, J. A1 - Ebert, H. A1 - Bauer, G. A1 - Freyse, Friedrich A1 - Varykhalov, Andrei A1 - Rader, Oliver A1 - Springholz, Gunther T1 - Large magnetic gap at the Dirac point in Bi2Te3/MnBi2Te4 heterostructures JF - Nature : the international weekly journal of science N2 - Magnetically doped topological insulators enable the quantum anomalous Hall effect (QAHE), which provides quantized edge states for lossless charge-transport applications(1-8). The edge states are hosted by a magnetic energy gap at the Dirac point(2), but hitherto all attempts to observe this gap directly have been unsuccessful. Observing the gap is considered to be essential to overcoming the limitations of the QAHE, which so far occurs only at temperatures that are one to two orders of magnitude below the ferromagnetic Curie temperature, T-C (ref. (8)). Here we use low-temperature photoelectron spectroscopy to unambiguously reveal the magnetic gap of Mn-doped Bi2Te3, which displays ferromagnetic out-of-plane spin texture and opens up only below T-C. Surprisingly, our analysis reveals large gap sizes at 1 kelvin of up to 90 millielectronvolts, which is five times larger than theoretically predicted(9). Using multiscale analysis we show that this enhancement is due to a remarkable structure modification induced by Mn doping: instead of a disordered impurity system, a self-organized alternating sequence of MnBi2Te4 septuple and Bi2Te3 quintuple layers is formed. This enhances the wavefunction overlap and size of the magnetic gap(10). Mn-doped Bi2Se3 (ref. (11)) and Mn-doped Sb2Te3 form similar heterostructures, but for Bi2Se3 only a nonmagnetic gap is formed and the magnetization is in the surface plane. This is explained by the smaller spin-orbit interaction by comparison with Mn-doped Bi2Te3. Our findings provide insights that will be crucial in pushing lossless transport in topological insulators towards room-temperature applications. Y1 - 2019 U6 - https://doi.org/10.1038/s41586-019-1826-7 SN - 0028-0836 SN - 1476-4687 VL - 576 IS - 7787 SP - 423 EP - 428 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Heinz, A. A1 - Voss, M. A1 - Lawrie, S. M. A1 - Mishara, A. A1 - Bauer, M. A1 - Gallinat, Jürgen A1 - Juckel, G. A1 - Lang, U. A1 - Rapp, Michael Armin A1 - Falkai, P. A1 - Strik, W. A1 - Krystal, J. A1 - Abi-Dargham, A. A1 - Galderisi, S. T1 - Shall we really say goodbye to first rank symptoms? JF - European psychiatry : the journal of the Association of European Psychiatrists N2 - Background: First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A' symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10 is currently under revision and may follow suit. In this review, we discuss central points of criticism that are directed against the continuous use of first rank symptoms (FRS) to diagnose schizophrenia. KW - First rank symptoms KW - Schizophrenia KW - ICD KW - DSM KW - Self-disorder Y1 - 2016 U6 - https://doi.org/10.1016/j.eurpsy.2016.04.010 SN - 0924-9338 SN - 1778-3585 VL - 37 SP - 8 EP - 13 PB - Elsevier CY - Paris ER - TY - JOUR A1 - Metzler, Ralf A1 - Bauer, Maximilian A1 - Rasmussen, Emil S. A1 - Lomholt, Michael A. T1 - Real sequence effects on the search dynamics of transcription factors on DNA JF - Scientific Reports N2 - Recent experiments show that transcription factors (TFs) indeed use the facilitated diffusion mechanism to locate their target sequences on DNA in living bacteria cells: TFs alternate between sliding motion along DNA and relocation events through the cytoplasm. From simulations and theoretical analysis we study the TF-sliding motion for a large section of the DNA-sequence of a common E. coli strain, based on the two-state TF-model with a fast-sliding search state and a recognition state enabling target detection. For the probability to detect the target before dissociating from DNA the TF-search times self-consistently depend heavily on whether or not an auxiliary operator (an accessible sequence similar to the main operator) is present in the genome section. Importantly, within our model the extent to which the interconversion rates between search and recognition states depend on the underlying nucleotide sequence is varied. A moderate dependence maximises the capability to distinguish between the main operator and similar sequences. Moreover, these auxiliary operators serve as starting points for DNA looping with the main operator, yielding a spectrum of target detection times spanning several orders of magnitude. Auxiliary operators are shown to act as funnels facilitating target detection by TFs. KW - gene regulatory networks KW - biological physics Y1 - 2015 U6 - https://doi.org/10.1038/srep10072 SN - 2045-2322 VL - 5 IS - 10072 PB - Nature Publishing Group CY - London ER - TY - GEN A1 - Metzler, Ralf A1 - Bauer, Maximilian A1 - Rasmussen, Emil S. A1 - Lomholt, Michael A. T1 - Real sequence effects on the search dynamics of transcription factors on DNA N2 - Recent experiments show that transcription factors (TFs) indeed use the facilitated diffusion mechanism to locate their target sequences on DNA in living bacteria cells: TFs alternate between sliding motion along DNA and relocation events through the cytoplasm. From simulations and theoretical analysis we study the TF-sliding motion for a large section of the DNA-sequence of a common E. coli strain, based on the two-state TF-model with a fast-sliding search state and a recognition state enabling target detection. For the probability to detect the target before dissociating from DNA the TF-search times self-consistently depend heavily on whether or not an auxiliary operator (an accessible sequence similar to the main operator) is present in the genome section. Importantly, within our model the extent to which the interconversion rates between search and recognition states depend on the underlying nucleotide sequence is varied. A moderate dependence maximises the capability to distinguish between the main operator and similar sequences. Moreover, these auxiliary operators serve as starting points for DNA looping with the main operator, yielding a spectrum of target detection times spanning several orders of magnitude. Auxiliary operators are shown to act as funnels facilitating target detection by TFs. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 189 KW - gene regulatory networks KW - biological physics Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-79411 ER - TY - JOUR A1 - Warschburger, Petra A1 - Busch, S. A1 - Bauer, C. P. A1 - Kiosz, D. A1 - Stachow, R. A1 - Petermann, Franz T1 - Health-related quality of life in children and adolescents with asthma : results from the ESTAR study N2 - Our aim was to assess the psychosocial well-being of asthmatic children and adolescents, the influencing factors, and to determine the effect of inpatient rehabilitation on their quality of life; 226 asthmatic children and adolescents participated in the inpatient rehabilitation (IG). The comparison group (CG) included 92 asthmatic children and adolescents receiving standard medical treatments. Patients were aged between 8 and 16 years and were predominantly male. The health-related quality of life was measured with the German version of the "Paediatric Asthma Quality of Life Questionnaire." Interviews were carried out for IG 2 weeks before the commencement of their inpatient stay and 1 year after their stay ended. The same time schedule was carried out for CG. All patients reported a mild to moderate impairment of their quality of life. Girls described a slightly lower quality of life than boys. With increasing asthma severity, quality of life decreased. Inpatients described a lower quality of life than CG at enrollment. Inpatient rehabilitation resulted in a greater improvement of quality of life over time for IG than for CG. Gender and severity status had no effect on this time course. The only modestly affected quality of life may reflect the good adaptation to the disease and medical treatment. Children and adolescents in the IG recorded improvements in their quality of life. Differences in quality of life based on gender and disease severity were not shown to influence the improvements. In summary, inpatient rehabilitation results in an improvement of health-related quality of life. Further research concerning the psychosocial situation of children and adolescents in this setting is needed Y1 - 2004 ER - TY - JOUR A1 - Pietsch, Ullrich A1 - Hesse, A. A1 - Zhuang, Y. A1 - Holý, Vaclav A1 - Stangl, Jochen A1 - Zerlauth, S. A1 - Schaffler, F. A1 - Bauer, Günther T1 - X-ray grazing-incidence study of inhomogeneous strain relaxation in Si/SiGe wires Y1 - 2003 SN - 0168-583X ER - TY - JOUR A1 - Springer, Mark S. A1 - Signore, Anthony V. A1 - Paijmans, Johanna L. A. A1 - Velez-Juarbe, Jorge A1 - Domning, Daryl P. A1 - Bauer, Cameron E. A1 - He, Kai A1 - Crerar, Lorelei A1 - Campos, Paula F. A1 - Murphy, William J. A1 - Meredith, Robert W. A1 - Gatesy, John A1 - Willerslev, Eske A1 - MacPhee, Ross D. E. A1 - Hofreiter, Michael A1 - Campbell, Kevin L. T1 - Interordinal gene capture, the phylogenetic position of Steller's sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia JF - Molecular phylogenetics and evolution N2 - The recently extinct (ca. 1768) Steller's sea cow (Hydrodamalis gigas) was a large, edentulous North Pacific sirenian. The phylogenetic affinities of this taxon to other members of this clade, living and extinct, are uncertain based on previous morphological and molecular studies. We employed hybridization capture methods and second generation sequencing technology to obtain >30 kb of exon sequences from 26 nuclear genes for both H. gigas and Dugong dugon. We also obtained complete coding sequences for the tooth-related enamelin (ENAM) gene. Hybridization probes designed using dugong and manatee sequences were both highly effective in retrieving sequences from H. gigas (mean = 98.8% coverage), as were more divergent probes for regions of ENAM (99.0% coverage) that were designed exclusively from a proboscidean (African elephant) and a hyracoid (Cape hyrax). New sequences were combined with available sequences for representatives of all other afrotherian orders. We also expanded a previously published morphological matrix for living and fossil Sirenia by adding both new taxa and nine new postcranial characters. Maximum likelihood and parsimony analyses of the molecular data provide robust support for an association of H. gigas and D. dugon to the exclusion of living trichechids (manatees). Parsimony analyses of the morphological data also support the inclusion of H. gigas in Dugongidae with D. dugon and fossil dugongids. Timetree analyses based on calibration density approaches with hard- and soft-bounded constraints suggest that H. gigas and D. dugon diverged in the Oligocene and that crown sirenians last shared a common ancestor in the Eocene. The coding sequence for the ENAM gene in H. gigas does not contain frameshift mutations or stop codons, but there is a transversion mutation (AG to CG) in the acceptor splice site of intron 2. This disruption in the edentulous Steller's sea cow is consistent with previous studies that have documented inactivating mutations in tooth-specific loci of a variety of edentulous and enamelless vertebrates including birds, turtles, aardvarks, pangolins, xenarthrans, and baleen whales. Further, branch-site dN/dS analyses provide evidence for positive selection in ENAM on the stem dugongid branch where extensive tooth reduction occurred, followed by neutral evolution on the Hydrodamalis branch. Finally, we present a synthetic evolutionary tree for living and fossil sirenians showing several key innovations in the history of this clade including character state changes that parallel those that occurred in the evolutionary history of cetaceans. (C) 2015 Elsevier Inc. All rights reserved. Y1 - 2015 U6 - https://doi.org/10.1016/j.ympev.2015.05.022 SN - 1055-7903 SN - 1095-9513 VL - 91 SP - 178 EP - 193 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Ansell, Stephen W. A1 - Stenoien, Hans K. A1 - Grundmann, Michael A1 - Schneider, Harald A1 - Hemp, Andreas A1 - Bauer, N. A1 - Russell, S. J. A1 - Vogel, Johannes C. T1 - Population structure and historical biogeography of European Arabidopsis lyrata N2 - Understanding the natural history of model organisms is important for the effective use of their genomic resourses. Arabidopsis lyrata has emerged as a useful plant for studying ecological and evolutionary genetics, based on its extensive natural variation, sequenced genome and close relationship to A. thaliana. We studied genetic diversity across the entire range of European Arabidopsis lyrata ssp. petraea, in order to explore how population history has influenced population structure. We sampled multiple populations from each region, using nuclear and chloroplast genome markers, and combined population genetic and phylogeographic approaches. Within-population diversity is substantial for nuclear allozyme markers (mean P = 0.610, A(e) = 1.580, H-e = 0.277) and significantly partitioned among populations (F- ST = 0.271). The Northern populations have modestly increased inbreeding (F-IS = 0.163 verses F-IS = 0.093), but retain comparable diversity to central European populations. Bottlenecks are common among central and northern Europe populations, indicating recent demographic history as a dominant factor in structuring the European diversity. Although the genetic structure was detected at all geographic scales, two clear differentiated units covering northern and central European areas (F-CT = 0.155) were identified by Bayesian analysis and supported by regional pairwise F-CT calculations. A highly similar geographic pattern was observed from the distribution of chloroplast haplotypes, with the dominant northern haplotypes absent from central Europe. We conclude A. l. petraea's cold-tolerance and preference for disturbed habitats enabled glacial survival between the alpine and Nordic glaciers in central Europe and an additional cryptic refugium. While German populations are probable peri-glacial leftovers, Eastern Austrian populations have diversity patterns possibly compatible with longer-term survival. Y1 - 2010 UR - http://www.nature.com/hdy/archive/index.html U6 - https://doi.org/10.1038/Hdy.2010.10 SN - 0018-067X ER - TY - JOUR A1 - Darowski, Nora A1 - Lübbert, Daniel A1 - Pietsch, Ullrich A1 - Zhuang, Y. A1 - Zerlauth, S. A1 - Bauer, Günther T1 - In-plane strain and strain relaxation in laterally patterned Si/SiGe quantum dots and wire arrays Y1 - 1998 ER - TY - JOUR A1 - Weber, Michael H. A1 - Helwig, S. L. A1 - Bauer, Klaus A1 - Haberland, Christian A1 - Koch, Olaf A1 - Ryberg, T. A1 - Maercklin, N. A1 - Ritter, O. A1 - Schulze, A. T1 - Near-surface properties of an active fault derived by joint interpretation of different geophysical methods - the Arava/Araba Fault in the Middle East JF - Near surface geophysics N2 - The motion of tectonic plates is accommodated at fault zones. One of the unanswered questions about fault zones relates to the role they play in controlling shallow and local hydrology. This study focuses on the Arava/Araba Fault (AF) zone, the southern portion of the Dead Sea Transform (DST) in the Middle East. We combine seismic and electromagnetic methods (EM) to image the geometry and map the petro-physical properties and water occurrence in the top 100 m of this active fault. For three profiles, P-velocity and resistivity images were derived independently. Using a neural network cluster analysis three classes with similar P-velocity and resistivities could then be determined from these images. These classes correspond to spatial domains of specific material and wetness. The first class occurs primarily east of the fault consisting of 'wet' sand (dunes) and brecciated sediments, whereas the second class composed of similar material located west of the fault is 'dry'. The third class lies at depth below ca. 50 m and is composed of highly deformed and weathered Precambrian rocks that constitute the multi-branch fault zone of the AF at this location. The combination of two independent measurements like seismics and EM linked by a stringent mathematical approach has thus shown the potential to delineate the interplay of lithology and water near active faults. Y1 - 2012 U6 - https://doi.org/10.3997/1873-0604.2012031 SN - 1569-4445 VL - 10 IS - 5 SP - 381 EP - 390 PB - European Association of Geoscientists & Engineers CY - Houten ER - TY - JOUR A1 - Bauer, Maximilian A1 - Rasmussen, Emil S. A1 - Lomholt, Michael A. A1 - Metzler, Ralf T1 - Real sequence effects on the search dynamics of transcription factors on DNA JF - Scientific reports N2 - Recent experiments show that transcription factors (TFs) indeed use the facilitated diffusion mechanism to locate their target sequences on DNA in living bacteria cells: TFs alternate between sliding motion along DNA and relocation events through the cytoplasm. From simulations and theoretical analysis we study the TF-sliding motion for a large section of the DNA-sequence of a common E. coli strain, based on the two-state TF-model with a fast-sliding search state and a recognition state enabling target detection. For the probability to detect the target before dissociating from DNA the TF-search times self-consistently depend heavily on whether or not an auxiliary operator (an accessible sequence similar to the main operator) is present in the genome section. Importantly, within our model the extent to which the interconversion rates between search and recognition states depend on the underlying nucleotide sequence is varied. A moderate dependence maximises the capability to distinguish between the main operator and similar sequences. Moreover, these auxiliary operators serve as starting points for DNA looping with the main operator, yielding a spectrum of target detection times spanning several orders of magnitude. Auxiliary operators are shown to act as funnels facilitating target detection by TFs. Y1 - 2015 U6 - https://doi.org/10.1038/srep10072 SN - 2045-2322 VL - 5 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Zhuang, Y. A1 - Schelling, Christoph A1 - Stangl, Jochen A1 - Penn, C. A1 - Senz, S. A1 - Schäffler, Friedrich A1 - Roche, T. A1 - Daniel, A. A1 - Grenzer, Jörg A1 - Pietsch, Ullrich A1 - Bauer, Günther T1 - Structural and optical properties of Si/Si{1-x}Ge{x} wires Y1 - 2000 ER - TY - JOUR A1 - Zhuang, Y. A1 - Pietsch, Ullrich A1 - Stangl, Jochen A1 - Holý, Vaclav A1 - Darowski, Nora A1 - Grenzer, Jörg A1 - Zerlauth, S. A1 - Schäffler, F. A1 - Bauer, Günther T1 - In-plane strain and shape analysis of Si/SiGe nanostructures by grazing incidence diffraction Y1 - 2000 ER - TY - JOUR A1 - Holý, Václav A1 - Stangl, Jochen A1 - Zerlauth, S. A1 - Bauer, Günther A1 - Darowski, Nora A1 - Lübbert, Daniel A1 - Pietsch, Ullrich T1 - Lateral arrangement of self-assembled quantum dots in an SiGe/Si superlattice Y1 - 1999 ER - TY - JOUR A1 - Zhuang, Y. A1 - Holý, Václav A1 - Stangl, Jochen A1 - Darhuber, A. A1 - Mikulik, P. A1 - Zerlauth, S. A1 - Schäffler, F. A1 - Bauer, Günther A1 - Darowski, Nora A1 - Lübbert, Daniel A1 - Pietsch, Ullrich T1 - Strain relaxation in periodic arrays of Si/SiGe quantum wires determined by coplanar high-resolution x-ray diffrcation and grazing-incidence diffraction Y1 - 1999 ER - TY - JOUR A1 - Holý, Václav A1 - Darhuber, A. A1 - Stangl, Jochen A1 - Zerlauth, S. A1 - Schäffler, F. A1 - Bauer, Günther A1 - Darowski, Nora A1 - Lübbert, Daniel A1 - Pietsch, Ullrich A1 - Vavra, I. T1 - HRXRD and GID investigations of a self-organized SiGe quantum dot multilayer Y1 - 1999 ER - TY - GEN A1 - Lang, Judith A1 - Bohn, Patrick A1 - Bhat, Hilal A1 - Jastrow, Holger A1 - Walkenfort, Bernd A1 - Cansiz, Feyza A1 - Fink, Julian A1 - Bauer, Michael A1 - Schumacher, Fabian A1 - Kleuser, Burkhard A1 - Lang, Karl S. T1 - Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs). In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of sphingosine-rich intraluminal vesicles (ILVs). Once HSV-1 particles reach MVBs, sphingosine-rich ILVs bind to HSV-1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infection. Lack of aCDase in macrophage cultures or in Asah1(-/-) mice results in replication of HSV-1 and Asah1(-/-) mice die soon after systemic or intravaginal inoculation. The treatment of macrophages with sphingosine enhancing compounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway. In conclusion, aCDase loads ILVs with sphingosine, which prevents HSV-1 capsids from penetrating into the cytosol. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1400 KW - immunology KW - infection KW - membrane fusion KW - phagocytosis KW - sphingolipids Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-515661 SN - 1866-8372 IS - 1 ER - TY - JOUR A1 - Lang, Judith A1 - Bohn, Patrick A1 - Bhat, Hilal A1 - Jastrow, Holger A1 - Walkenfort, Bernd A1 - Cansiz, Feyza A1 - Fink, Julian A1 - Bauer, Michael A1 - Schumacher, Fabian A1 - Kleuser, Burkhard A1 - Lang, Karl S. T1 - Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease JF - Nature Communications N2 - Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs). In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of sphingosine-rich intraluminal vesicles (ILVs). Once HSV-1 particles reach MVBs, sphingosine-rich ILVs bind to HSV-1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infection. Lack of aCDase in macrophage cultures or in Asah1(-/-) mice results in replication of HSV-1 and Asah1(-/-) mice die soon after systemic or intravaginal inoculation. The treatment of macrophages with sphingosine enhancing compounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway. In conclusion, aCDase loads ILVs with sphingosine, which prevents HSV-1 capsids from penetrating into the cytosol. KW - immunology KW - infection KW - membrane fusion KW - phagocytosis KW - sphingolipids Y1 - 2020 U6 - https://doi.org/10.1038/s41467-020-15072-8 SN - 2041-1723 VL - 11 IS - 1 SP - 1 EP - 15 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Zen, Achmad A1 - Neher, Dieter A1 - Bauer, C. A1 - Asawapirom, Udom A1 - Scherf, Ullrich A1 - Hagen, R. A1 - Kostromine, S. A1 - Mahrt, R. F. T1 - Polarization-sensitive photoconductivity in aligned polyfluorene layers Y1 - 2002 ER - TY - JOUR A1 - Bauer, C. A1 - Böhmer, Roland A1 - Moreno-Flores, S. A1 - Richert, R. A1 - Sillescu, H. A1 - Neher, Dieter T1 - Capacitive scanning dilatometry and frequency dependent thermal expansion of polymer films Y1 - 2000 ER - TY - JOUR A1 - Ratzloff, Jeffrey K. A1 - Barlow, Brad N. A1 - Kupfer, Thomas A1 - Corcoran, Kyle A. A1 - Geier, Stephan A1 - Bauer, Evan A1 - Corbett, Henry T. A1 - Howard, Ward S. A1 - Glazier, Amy A1 - Law, Nicholas M. T1 - EVR-CB-001: An Evolving, Progenitor, White Dwarf Compact Binary Discovered with the Evryscope JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We present EVR-CB-001, the discovery of a compact binary with an extremely low-mass (0.21 +/- 0.05M(circle dot)) helium core white dwarf progenitor (pre-He WD) and an unseen low-mass (0.32 +/- 0.06M(circle dot)) helium white dwarf (He WD) companion. He WDs are thought to evolve from the remnant helium-rich core of a main-sequence star stripped during the giant phase by a close companion. Low-mass He WDs are exotic objects (only about 0.2% of WDs are thought to be less than 0.3 M-circle dot), and are expected to be found in compact binaries. Pre-He WDs are even rarer, and occupy the intermediate phase after the core is stripped, but before the star becomes a fully degenerate WD and with a larger radius (approximate to 0.2R(circle dot)) than a typical WD. The primary component of EVR-CB-001 (the pre-He WD) was originally thought to be a hot subdwarf (sdB) star from its blue color and under-luminous magnitude, characteristic of sdBs. The mass, temperature (T-eff = 18,500 +/- 500 K), and surface gravity (log(g) = 4.96 +/- 0.04) solutions from this work are lower than values for typical hot subdwarfs. The primary is likely to be a post-red-giant branch, pre-He WD contracting into a He WD, and at a stage that places it nearest to sdBs on color-magnitude and T-eff-log(g) diagrams. EVR-CB-001 is expected to evolve into a fully double degenerate, compact system that should spin down and potentially evolve into a single hot subdwarf star. Single hot subdwarfs are observed, but progenitor systems have been elusive. Y1 - 2019 U6 - https://doi.org/10.3847/1538-4357/ab3727 SN - 0004-637X SN - 1538-4357 VL - 883 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER -