TY  - JOUR
A1  - Rodriguez Cubillos, Andres Eduardo
A1  - Tong, Hao
A1  - Alseekh, Saleh
A1  - de Abreu e Lima, Francisco Anastacio
A1  - Yu, Jing
A1  - Fernie, Alisdair R.
A1  - Nikoloski, Zoran
A1  - Laitinen, Roosa A. E.
T1  - Inheritance patterns in metabolism and growth in diallel crosses of Arabidopsis thaliana from a single growth habitat
JF  - Heredity
N2  - Metabolism is a key determinant of plant growth and modulates plant adaptive responses. Increased metabolic variation due to heterozygosity may be beneficial for highly homozygous plants if their progeny is to respond to sudden changes in the habitat. Here, we investigate the extent to which heterozygosity contributes to the variation in metabolism and size of hybrids of Arabidopsis thaliana whose parents are from a single growth habitat. We created full diallel crosses among seven parents, originating from Southern Germany, and analysed the inheritance patterns in primary and secondary metabolism as well as in rosette size in situ. In comparison to primary metabolites, compounds from secondary metabolism were more variable and showed more pronounced non-additive inheritance patterns which could be attributed to epistasis. In addition, we showed that glucosinolates, among other secondary metabolites, were positively correlated with a proxy for plant size. Therefore, our study demonstrates that heterozygosity in local A. thaliana population generates metabolic variation and may impact several tasks directly linked to metabolism.
Y1  - 2018
U6  - https://doi.org/10.1038/s41437-017-0030-5
SN  - 0018-067X
SN  - 1365-2540
VL  - 120
IS  - 5
SP  - 463
EP  - 473
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Laitinen, Roosa A. E.
A1  - Nikoloski, Zoran
T1  - Genetic basis of plasticity in plants
JF  - Journal of experimental botany
N2  - The ability of an organism to change its phenotype in response to different environments, termed plasticity, is a particularly important characteristic to enable sessile plants to adapt to rapid changes in their surroundings. Plasticity is a quantitative trait that can provide a fitness advantage and mitigate negative effects due to environmental perturbations. Yet, its genetic basis is not fully understood. Alongside technological limitations, the main challenge in studying plasticity has been the selection of suitable approaches for quantification of phenotypic plasticity. Here, we propose a categorization of the existing quantitative measures of phenotypic plasticity into nominal and relative approaches. Moreover, we highlight the recent advances in the understanding of the genetic architecture underlying phenotypic plasticity in plants. We identify four pillars for future research to uncover the genetic basis of phenotypic plasticity, with emphasis on development of computational approaches and theories. These developments will allow us to perform specific experiments to validate the causal genes for plasticity and to discover their role in plant fitness and evolution.
KW  - Genetic architecture
KW  - GWA
KW  - GxE interaction
KW  - hub genes
KW  - plant adaptation
KW  - plasticity
KW  - variance
Y1  - 2018
U6  - https://doi.org/10.1093/jxb/ery404
SN  - 0022-0957
SN  - 1460-2431
VL  - 70
IS  - 3
SP  - 739
EP  - 745
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Pandey, Prashant K.
A1  - Yu, Jing
A1  - Omranian, Nooshin
A1  - Alseekh, Saleh
A1  - Vaid, Neha
A1  - Fernie, Alisdair R.
A1  - Nikoloski, Zoran
A1  - Laitinen, Roosa A. E.
T1  - Plasticity in metabolism underpins local responses to nitrogen in Arabidopsis thaliana populations
JF  - Plant Direct
N2  - Nitrogen (N) is central for plant growth, and metabolic plasticity can provide a strategy to respond to changing N availability. We showed that two local A. thaliana populations exhibited differential plasticity in the compounds of photorespiratory and starch degradation pathways in response to three N conditions. Association of metabolite levels with growth-related and fitness traits indicated that controlled plasticity in these pathways could contribute to local adaptation and play a role in plant evolution.
KW  - Arabidopsis thaliana
KW  - natural variation
KW  - nitrogen availability
KW  - photorespiration
KW  - plasticity
Y1  - 2019
U6  - https://doi.org/10.1002/pld3.186
SN  - 2475-4455
VL  - 3
IS  - 11
PB  - John Wiley & sonst LTD
CY  - Chichester
ER  -