TY  - JOUR
A1  - Mueller-Nordhorn, Jacqueline
A1  - Muckelbauer, Rebecca
A1  - Englert, Heike
A1  - Grittner, Ulrike
A1  - Berger, Hendrike
A1  - Sonntag, Frank
A1  - Völler, Heinz
A1  - Prugger, Christof
A1  - Wegscheider, Karl
A1  - Katus, Hugo A.
A1  - Willich, Stefan N.
T1  - Longitudinal association between body mass index and health-related quality of life
JF  - PLoS one
N2  - Objective: Health-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity.
 Design: Secondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy.
 Methods: HRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time.
 Results: Of the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (beta [95% CI] per 1 kg/ m(2) : -0.36 [-0.41; -0.30] and -0.05 [-0.11; -0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (-0.18 [-0.27; -0.09]) and only in obese participants (-0.19 [-0.29; -0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population.
 Conclusion: Increases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pone.0093071
SN  - 1932-6203
VL  - 9
IS  - 3
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Muckelbauer, Rebecca
A1  - Englert, Heike
A1  - Rieckmann, Nina
A1  - Chen, Chih-Mei
A1  - Wegscheider, Karl
A1  - Völler, Heinz
A1  - Katus, Hugo A.
A1  - Willich, Stefan N.
A1  - Müller-Nordhorn, Jacqueline
T1  - Long-term effect of a low-intensity smoking intervention embedded in an adherence program for patients with hypercholesterolemia: Randomized controlled trial
JF  - Preventive medicine : an international journal devoted to practice and theory
N2  - Objective. We evaluated the long-term effect of a smoking intervention embedded in an adherence program in patients with an increased risk for cardiovascular disease.
 Method. Secondary analysis of a randomized controlled trial: In 2002-2004,8108 patients with hypercholesterolemia were enrolled from general practices in Germany. Patients received a 12-month adherence program and statin medication (intervention) or statin medication only (control). The program aimed to improve adherence to medication and lifestyle by educational material, mailings, and phone calls. Smoking was self-reported at baseline and every 6 months during the 3-year follow-up.
 Results. In total, 7640 patients were analyzed. At baseline, smoking prevalence was 21.7% in the intervention and 21.5% in the control group. Prevalence decreased in both groups to 16.6% vs. 19.5%, 153% vs. 16.8%, and 14.2% vs. 15.6% at the 12-, 24-, and 36-month follow-up. The intervention had a beneficial effect on smoking differing over time (group x time: P = 0.005). The effect was largest after 6 and 12 months [odds ratios (95% confidence intervals): 0.67 (0.54-0.82) and 0.63 (0.51-0.78)]. The effect decreased until the 18-month follow-up [0.72 (0.58-0.90)] and was not significant after 24 months.
 Conclusion. A low-intensity smoking intervention embedded in an adherence program can contribute to smoking cessation although the intervention effect diminished over time. (C) 2015 Elsevier Inc. All rights reserved.
KW  - Smoking
KW  - Smoking cessation
KW  - Cardiovascular risk factors
KW  - Health promotion
KW  - Randomized controlled trial
KW  - Multiple risk factor intervention
KW  - Hypercholesterolemia
Y1  - 2015
U6  - https://doi.org/10.1016/j.ypmed.2015.05.026
SN  - 0091-7435
SN  - 1096-0260
VL  - 77
SP  - 155
EP  - 161
PB  - Elsevier
CY  - San Diego
ER  -