TY  - JOUR
A1  - Pan, Yuanwei
A1  - Ma, Xuehua
A1  - Liu, Chuang
A1  - Xing, Jie
A1  - Zhou, Suqiong
A1  - Parshad, Badri
A1  - Schwerdtle, Tanja
A1  - Li, Wenzhong
A1  - Wu, Aiguo
A1  - Haag, Rainer
T1  - Retinoic acid-loaded dendritic polyglycerol-conjugated gold nanostars for targeted photothermal therapy in breast cancer stem cells
JF  - ACS nano
N2  - The existence of cancer stem cells (CSCs) poses a major obstacle for the success of current cancer therapies, especially the fact that non-CSCs can spontaneously turn into CSCs, which lead to the failure of the treatment and tumor relapse. Therefore, it is very important to develop effective strategies for the eradication of the CSCs. In this work, we have developed a CSCs-specific targeted, retinoic acid (RA)-loaded gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatform for the efficient eradication of CSCs. The nanocomposites possess good biocompatibility and exhibit effective CSCs-specific multivalent targeted capability due to hyaluronic acid (HA) decorated on the multiple attachment sites of the bioinert dendritic polyglycerol (dPG). With the help of CSCs differentiation induced by RA, the self-renewal of breast CSCs and tumor growth were suppressed by the high therapeutic efficacy of photothermal therapy (PTT) in a synergistic inhibitory manner. Moreover, the stemness gene expression and CSC-driven tumorsphere formation were significantly diminished. In addition, the in vivo tumor growth and CSCs were also effectively eliminated, which indicated superior anticancer activity, effective CSCs suppression, and prevention of relapse. Taken together, we developed a CSCs-specific targeted, RA-loaded GNSs-dPG nanoplatform for the targeted eradication of CSCs and for preventing the relapse.
KW  - cancer stem cells
KW  - dendritic polyglycerol
KW  - gold nanostars
KW  - retinoic acid
KW  - photothermal therapy
Y1  - 2021
U6  - https://doi.org/10.1021/acsnano.1c05452
SN  - 1936-0851
SN  - 1936-086X
VL  - 15
IS  - 9
SP  - 15069
EP  - 15084
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Li, Mingjun
A1  - Schlaich, Christoph
A1  - Zhang, Jianguang
A1  - Donskyi, Ievgen
A1  - Schwibbert, Karin
A1  - Schreiber, Frank
A1  - Xia, Yi
A1  - Radnik, Jörg
A1  - Schwerdtle, Tanja
A1  - Haag, Rainer
T1  - Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction
JF  - Journal of materials science & technology : JMST ; an international journal / spons. by the Chinese Society for Metals (CSM), the Chinese Materials Research Society (CMRS), Institute of Metal Research, Chinese Academy of Sciences
N2  - Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles (CuNPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol (MI-hPG) coating via a simple dip-coating method. This hyperbranched polyglycerol with 10 % catechol groups' modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone (PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated CuNPs-incorporated PCL membrane [PCL-(MI-hPG)-CuNPs] was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-hPG)-CuNPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing CuNPs.
KW  - Mussel-inspired coating
KW  - CuNPs
KW  - Multi-resistant bacteria
KW  - Antibacterial
KW  - Antifouling
KW  - Osteogenesis
Y1  - 2021
U6  - https://doi.org/10.1016/j.jmst.2020.08.011
SN  - 1005-0302
SN  - 1941-1162
VL  - 68
SP  - 160
EP  - 171
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -