TY  - JOUR
A1  - Pan, Yuanwei
A1  - Ma, Xuehua
A1  - Liu, Chuang
A1  - Xing, Jie
A1  - Zhou, Suqiong
A1  - Parshad, Badri
A1  - Schwerdtle, Tanja
A1  - Li, Wenzhong
A1  - Wu, Aiguo
A1  - Haag, Rainer
T1  - Retinoic acid-loaded dendritic polyglycerol-conjugated gold nanostars for targeted photothermal therapy in breast cancer stem cells
JF  - ACS nano
N2  - The existence of cancer stem cells (CSCs) poses a major obstacle for the success of current cancer therapies, especially the fact that non-CSCs can spontaneously turn into CSCs, which lead to the failure of the treatment and tumor relapse. Therefore, it is very important to develop effective strategies for the eradication of the CSCs. In this work, we have developed a CSCs-specific targeted, retinoic acid (RA)-loaded gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatform for the efficient eradication of CSCs. The nanocomposites possess good biocompatibility and exhibit effective CSCs-specific multivalent targeted capability due to hyaluronic acid (HA) decorated on the multiple attachment sites of the bioinert dendritic polyglycerol (dPG). With the help of CSCs differentiation induced by RA, the self-renewal of breast CSCs and tumor growth were suppressed by the high therapeutic efficacy of photothermal therapy (PTT) in a synergistic inhibitory manner. Moreover, the stemness gene expression and CSC-driven tumorsphere formation were significantly diminished. In addition, the in vivo tumor growth and CSCs were also effectively eliminated, which indicated superior anticancer activity, effective CSCs suppression, and prevention of relapse. Taken together, we developed a CSCs-specific targeted, RA-loaded GNSs-dPG nanoplatform for the targeted eradication of CSCs and for preventing the relapse.
KW  - cancer stem cells
KW  - dendritic polyglycerol
KW  - gold nanostars
KW  - retinoic acid
KW  - photothermal therapy
Y1  - 2021
U6  - https://doi.org/10.1021/acsnano.1c05452
SN  - 1936-0851
SN  - 1936-086X
VL  - 15
IS  - 9
SP  - 15069
EP  - 15084
PB  - American Chemical Society
CY  - Washington
ER  -