TY  - JOUR
A1  - Li, Mingjun
A1  - Schlaich, Christoph
A1  - Kulka, Michael Willem
A1  - Donskyi, Ievgen S.
A1  - Schwerdtle, Tanja
A1  - Unger, Wolfgang E. S.
A1  - Haag, Rainer
T1  - Mussel-inspired coatings with tunable wettability, for enhanced antibacterial efficiency and reduced bacterial adhesion
JF  - Journal of materials chemistry : B, Materials for biology and medicine
N2  - Over the last few decades, there has been a tremendous increase in research on antibacterial surface coatings as an alternative strategy against bacterial infections. Although there are several examples of effective strategies to prevent bacterial adhesion, the effect of the wetting properties on the coating was rarely considered as a crucial factor. Here we report an in-depth study on the effect of extreme wettability on the antibacterial efficiency of a silver nanoparticles ( AgNPs)-based coating. By controlling surface polymerization of mussel-inspired dendritic polyglycerol ( MI-dPG) and post-functionalization, surfaces with wetting properties ranging from superhydrophilic to superhydrophobic were fabricated. Subsequently, AgNPs were embedded into the coatings by applying in situ reduction using the free catechols-moieties present in the MI-dPG coating. The resulting polymer coatings exhibited excellent antibacterial ability against planktonic Escherichia coli ( E. coli) DH5a and Staphylococcus aureus ( S. aureus) SH1000. The antibacterial efficiency of the coatings was analyzed by using inductively coupled plasma mass spectrometry ( ICP-MS) and bacterial viability tests. Furthermore, the antifouling properties of the coatings in relation to the antibacterial properties were evaluated.
Y1  - 2019
U6  - https://doi.org/10.1039/c9tb00534j
SN  - 2050-750X
SN  - 2050-7518
VL  - 7
IS  - 21
SP  - 3438
EP  - 3445
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Li, Mingjun
A1  - Gao, Lingyan
A1  - Schlaich, Christoph
A1  - Zhang, Jianguang
A1  - Donskyi, Ievgen S.
A1  - Yu, Guozhi
A1  - Li, Wenzhong
A1  - Tu, Zhaoxu
A1  - Rolff, Jens
A1  - Schwerdtle, Tanja
A1  - Haag, Rainer
A1  - Ma, Nan
T1  - Construction of Functional Coatings with Durable and Broad-Spectrum Antibacterial Potential Based on Mussel-Inspired Dendritic Polyglycerol and in Situ-Formed Copper Nanoparticles
JF  - ACS applied materials & interfaces
N2  - A novel surface coating with durable broad-spectrum antibacterial ability was prepared based on mussel inspired dendritic polyglycerol (MI-dPG) embedded with copper nanoparticles (Cu NPs). The functional surface coating is fabricated via a facile dip-coating process followed by in situ reduction of copper ions with a MI-dPG coating to introduce Cu NPs into the coating matrix. This coating has been demonstrated to possess efficient long-term antibacterial properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and kanamycin-resistant E. coli through an "attract-kill-release" strategy. The synergistic antibacterial activity of the coating was shown by the combination of two functions of the contact killing, reactive oxygen species production and Cu ions released from the coating. Furthermore, this coating inhibited biofilm formation and showed good compatibility to eukaryotic cells. Thus, this newly developed Cu NP-incorporated MI-dPG surface coating may find potential application in the design of antimicrobial coating, such as implantable devices.
KW  - Cu NP-incorporated MI-dPG coating
KW  - universal coating
KW  - in situ chemical reduction
KW  - antibacterial effect
KW  - drug-resistant bacteria
Y1  - 2017
U6  - https://doi.org/10.1021/acsami.7b10541
SN  - 1944-8244
VL  - 9
SP  - 35411
EP  - 35418
PB  - American Chemical Society
CY  - Washington
ER  -