TY  - JOUR
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brose, Robert
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Chromey, A. J.
A1  - Cui, Wei
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, J. P.
A1  - Fortson, Lucy
A1  - Furniss, Amy
A1  - Gent, A.
A1  - Gueta, O.
A1  - Hanna, David
A1  - Hassan, T.
A1  - Hervet, Olivier
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, Adam Nepomuk
A1  - Pandel, D.
A1  - Park, N.
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Sadeh, I
A1  - Santander, Marcos
A1  - Scott, S. S.
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Sushch, Iurii
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
T1  - A Search for Pulsed Very High-energy Gamma-Rays from 13 Young Pulsars in Archival VERITAS Data
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We conduct a search for periodic emission in the very high-energy (VHE) gamma-ray band (E > 100 GeV) from a total of 13 pulsars in an archival VERITAS data set with a total exposure of over 450 hr. The set of pulsars includes many of the brightest young gamma-ray pulsars visible in the Northern Hemisphere. The data analysis resulted in nondetections of pulsed VHE gamma-rays from each pulsar. Upper limits on a potential VHE gamma-ray flux are derived at the 95% confidence level above three energy thresholds using two methods. These are the first such searches for pulsed VHE emission from each of the pulsars, and the obtained limits constrain a possible flux component manifesting at VHEs as is seen for the Crab pulsar.
KW  - gamma rays: general
KW  - pulsars: general
KW  - stars: neutron
Y1  - 2019
U6  - https://doi.org/10.3847/1538-4357/ab14f4
SN  - 0004-637X
SN  - 1538-4357
VL  - 876
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brill, A.
A1  - Brose, Robert
A1  - Buckley, J. H.
A1  - Christiansen, Jessie L.
A1  - Chromey, A. J.
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, John P.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Gillanders, Gerard H.
A1  - Gueta, O.
A1  - Hanna, David
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, Maria
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, Marcos
A1  - Scott, S. S.
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Kaur, A.
T1  - VERITAS Observations of the BL Lac Object TXS 0506+056
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters
N2  - On 2017 September 22, the IceCube Neutrino Observatory reported the detection of the high-energy neutrino event IC 170922A, of potential astrophysical origin. It was soon determined that the neutrino direction was consistent with the location of the gamma-ray blazar TXS 0506+056. (3FGL J0509.4+ 0541), which was in an elevated gamma-ray emission state as measured by the Fermi satellite. Very Energetic Radiation Imaging Telescope Array System (VERITAS) observations of the neutrino/blazar region started on 2017 September 23 in response to the neutrino alert and continued through 2018 February 6. While no significant very-high-energy (VHE; E > 100 GeV) emission was observed from the blazar by VERITAS in the two-week period immediately following the IceCube alert, TXS 0506+ 056 was detected by VERITAS with a significance of 5.8 standard deviations (sigma) in the full 35 hr data set. The average photon flux of the source during this period was (8.9 +/- 1.6). x. 10(-12) cm(-2) s(-1), or 1.6% of the Crab Nebula flux, above an energy threshold of 110 GeV, with a soft spectral index of 4.8. +/-. 1.3.
KW  - astroparticle physics
KW  - BL Lacertae objects: individual (TXS 0506+056, VER J0509+057)
KW  - gamma rays: galaxies
KW  - quasars: general
KW  - neutrinos
Y1  - 2018
U6  - https://doi.org/10.3847/2041-8213/aad053
SN  - 2041-8205
SN  - 2041-8213
VL  - 861
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Archambault, S.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Bourbeau, E.
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cerruti, M.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dwarkadas, Vikram V.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Fleischhack, H.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Griffin, S.
A1  - Huetten, M.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nieto, D.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, Nahee
A1  - Pohl, Martin
A1  - Popkow, A.
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Slane, P.
A1  - Staszak, D.
A1  - Telezhinsky, Igor O.
A1  - Trepanier, S.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Zitzer, B.
T1  - Gamma-ray Observations of Tycho's Supernova Remnant with VERITAS and Fermi
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
KW  - material
KW  - data behind figure
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/836/1/23
SN  - 0004-637X
SN  - 1538-4357
VL  - 836
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archer, A.
A1  - Aune, Taylor
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brose, Robert
A1  - Buchovecky, M.
A1  - Bugaev, V.
A1  - Cui, Wei
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, John P.
A1  - Fleischhack, H.
A1  - Flinders, A.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Gotthelf, Eric V.
A1  - Grube, J.
A1  - Hanna, David
A1  - Hervet, O.
A1  - Holder, J.
A1  - Huang, K.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Huetten, M.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, Maria
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, Gernot
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, Adam Nepomuk
A1  - Pandel, Dirk
A1  - Park, Nahee
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Popkow, Alexis
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Rousselle, J.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Tyler, J.
A1  - Vassiliev, V. V.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, David A.
A1  - Zitzer, B.
T1  - A Very High Energy gamma-Ray Survey toward the Cygnus Region of the Galaxy
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present results from deep observations toward the Cygnus region using 300 hr of very high energy (VHE)gamma-ray data taken with the VERITAS Cerenkov telescope array and over 7 yr of high-energy.-ray data taken with the Fermi satellite at an energy above 1 GeV. As the brightest region of diffuse gamma-ray emission in the northern sky, the Cygnus region provides a promising area to probe the origins of cosmic rays. We report the identification of a potential Fermi-LAT counterpart to VER J2031+415 (TeV J2032+4130) and resolve the extended VHE source VER J2019+368 into two source candidates (VER J2018+367* and VER J2020+368*) and characterize their energy spectra. The Fermi-LAT morphology of 3FGL J2021.0+4031e (the Gamma Cygni supernova remnant) was examined, and a region of enhanced emission coincident with VER J2019+407 was identified and jointly fit with the VERITAS data. By modeling 3FGL J2015.6+3709 as two sources, one located at the location of the pulsar wind nebula CTB 87 and one at the quasar QSO J2015+371, a continuous spectrum from 1 GeV to 10 TeV was extracted for VER J2016+371 (CTB 87). An additional 71 locations coincident with Fermi-LAT sources and other potential objects of interest were tested for VHE gamma-ray emission, with no emission detected and upper limits on the differential flux placed at an average of 2.3% of the Crab Nebula flux. We interpret these observations in a multiwavelength context and present the most detailed gamma-ray view of the region to date.
KW  - acceleration of particles
KW  - cosmic rays
KW  - gamma rays: general
KW  - ISM: supernova remnants
Y1  - 2018
U6  - https://doi.org/10.3847/1538-4357/aac4a2
SN  - 0004-637X
SN  - 1538-4357
VL  - 861
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brose, Robert
A1  - Buchovecky, M.
A1  - Bugaev, V.
A1  - Connolly, M. P.
A1  - Cui, Wei
A1  - Errando, Manel
A1  - Falcone, A.
A1  - Feng, Qi
A1  - Finley, John P.
A1  - Flinders, A.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Gillanders, Gerard H.
A1  - Huetten, M.
A1  - Hanna, David
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Johnson, Caitlin A.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, Maria
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, Gernot
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Park, N.
A1  - Perkins, Jeremy S.
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Popkow, Alexis
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Rulten, C.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, Karlen
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weiner, O. M.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, David A.
A1  - Zitzer, B.
A1  - Vurm, Indrek
A1  - Beloborodov, Andrei
T1  - A Strong Limit on the Very-high-energy Emission from GRB 150323A
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - On 2015 March 23, the Very Energetic Radiation Imaging Telescope Array System (VERITAS) responded to a Swift-Burst Alert Telescope (BAT) detection of a gamma-ray burst, with observations beginning 270 s after the onset of BAT emission, and only 135 s after the main BAT emission peak. No statistically significant signal is detected above 140 GeV. The VERITAS upper limit on the fluence in a 40-minute integration corresponds to about 1% of the prompt fluence. Our limit is particularly significant because the very-high-energy (VHE) observation started only similar to 2 minutes after the prompt emission peaked, and Fermi-Large Area Telescope observations of numerous other bursts have revealed that the high-energy emission is typically delayed relative to the prompt radiation and lasts significantly longer. Also, the proximity of GRB 150323A (z = 0.593) limits the attenuation by the extragalactic background light to similar to 50% at 100-200 GeV. We conclude that GRB 150323A had an intrinsically very weak high-energy afterglow, or that the GeV spectrum had a turnover below similar to 100 GeV. If the GRB exploded into the stellar wind of a massive progenitor, the VHE non-detection constrains the wind density parameter to be A greater than or similar to 3 x 10(11) g . cm(-1), consistent with a standard Wolf-Rayet progenitor. Alternatively, the VHE emission from the blast wave would be weak in a very tenuous medium such as the interstellar medium, which therefore cannot be ruled out as the environment of GRB 150323A.
KW  - gamma rays: general
KW  - gamma-ray burst: general
KW  - gamma-ray burst: individual (GRB 150323A)
Y1  - 2018
U6  - https://doi.org/10.3847/1538-4357/aab371
SN  - 0004-637X
SN  - 1538-4357
VL  - 857
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Oberauer, Klaus
A1  - Hornig, R.
A1  - Weidenfeld, Andrea
A1  - Wilhelm, Oliver
T1  - Effects of directionality in deductive reasoning : II. Premise integration and conclusion evaluation
N2  - Previous research (Oberauer & Wilhelm, 2000) has shown an inherent directionality between the two terms linked in premises of typical deductive reasoning tasks. With three experiments we investigated the effect of inherent directionality on the time to integrate two premises and for the derivation of a conclusion. We varied figure (i.e., order of terms in the premises) and direction of inference (i.e., order of terms in the conclusion) in deduction tasks from various domains (propositional reasoning, syllogisms, spatial, temporal, and linear order reasoning). Effects of figure on premise reading times varied with the directionality of the relations. Effects of direction of inference reflected the same directionality for a subset of relations. We propose that two factors are jointly responsible for a large part of observed directionality effects in premise integration: the inherent directionality of relational statements and a general advantage for a given-new order of terms in the second premise. Difficulty of deriving a conclusion is affected by the directionality or relations if and only if the relation is semantically asymmetric, so that the directionality must be preserved in the integrated mental model
Y1  - 2005
SN  - 0272-4987
ER  - 
TY  - JOUR
A1  - Archambault, S.
A1  - Archer, A.
A1  - Benbow, W.
A1  - Buchovecky, M.
A1  - Bugaev, V.
A1  - Cerruti, M.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Falcone, A.
A1  - Alonso, M. Fernandez
A1  - Finley, J. P.
A1  - Fleischhack, H.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Griffin, S.
A1  - Hutten, M.
A1  - Hervet, O.
A1  - Holder, J.
A1  - Humensky, T. B.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, G.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Nieto, D.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Pohl, M.
A1  - Popkow, A.
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Rovero, A. C.
A1  - Sadeh, I.
A1  - Shahinyan, K.
A1  - Staszak, D.
A1  - Telezhinsky, Igor O.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Zitzer, B.
T1  - Search for Magnetically Broadened Cascade Emission from Blazars with VERITAS
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present a search for magnetically broadened gamma-ray emission around active galactic nuclei (AGNs), using VERITAS observations of seven hard-spectrum blazars. A cascade process occurs when multi-TeV gamma-rays from an AGN interact with extragalactic background light (EBL) photons to produce electron-positron pairs, which then interact with cosmic microwave background photons via inverse-Compton scattering to produce gamma-rays. Due to the deflection of the electron- positron pairs, a non-zero intergalactic magnetic field (IGMF) would potentially produce detectable effects on the angular distribution of the cascade emission. In particular, an angular broadening compared to the unscattered emission could occur. Through non-detection of angularly broadened emission from 1ES 1218 vertical bar 304, the source with the largest predicted cascade fraction, we exclude a range of IGMF strengths around 10(-14) G at the 95% confidence level. The extent of the exclusion range varies with the assumptions made about the intrinsic spectrum of 1ES. 1218+304 and the EBL model used in the simulation of the cascade process. All of the sources are used to set limits on the flux due to extended emission.
KW  - BL Lacertae objects: general
KW  - galaxies: active
KW  - gamma rays: galaxies
KW  - magnetic fields
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/835/2/288
SN  - 0004-637X
SN  - 1538-4357
VL  - 835
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Oberauer, Klaus
A1  - Wilhelm, Oliver
A1  - Rosas, D. R.
T1  - Bayesian rationality for the selection task? : a test of optimal data selection theory
Y1  - 1999
ER  - 
TY  - JOUR
A1  - Khider, D.
A1  - Emile-Geay, J.
A1  - McKay, N. P.
A1  - Gil, Y.
A1  - Garijo, D.
A1  - Ratnakar, V
A1  - Alonso-Garcia, M.
A1  - Bertrand, S.
A1  - Bothe, O.
A1  - Brewer, P.
A1  - Bunn, A.
A1  - Chevalier, M.
A1  - Comas-Bru, L.
A1  - Csank, A.
A1  - Dassie, E.
A1  - DeLong, K.
A1  - Felis, T.
A1  - Francus, P.
A1  - Frappier, A.
A1  - Gray, W.
A1  - Goring, S.
A1  - Jonkers, L.
A1  - Kahle, M.
A1  - Kaufman, D.
A1  - Kehrwald, N. M.
A1  - Martrat, B.
A1  - McGregor, H.
A1  - Richey, J.
A1  - Schmittner, A.
A1  - Scroxton, N.
A1  - Sutherland, E.
A1  - Thirumalai, Kaustubh
A1  - Allen, K.
A1  - Arnaud, F.
A1  - Axford, Y.
A1  - Barrows, T.
A1  - Bazin, L.
A1  - Birch, S. E. Pilaar
A1  - Bradley, E.
A1  - Bregy, J.
A1  - Capron, E.
A1  - Cartapanis, O.
A1  - Chiang, H-W
A1  - Cobb, K. M.
A1  - Debret, M.
A1  - Dommain, Réne
A1  - Du, J.
A1  - Dyez, K.
A1  - Emerick, S.
A1  - Erb, M. P.
A1  - Falster, G.
A1  - Finsinger, W.
A1  - Fortier, D.
A1  - Gauthier, Nicolas
A1  - George, S.
A1  - Grimm, E.
A1  - Hertzberg, J.
A1  - Hibbert, F.
A1  - Hillman, A.
A1  - Hobbs, W.
A1  - Huber, M.
A1  - Hughes, A. L. C.
A1  - Jaccard, S.
A1  - Ruan, J.
A1  - Kienast, M.
A1  - Konecky, B.
A1  - Le Roux, G.
A1  - Lyubchich, V
A1  - Novello, V. F.
A1  - Olaka, L.
A1  - Partin, J. W.
A1  - Pearce, C.
A1  - Phipps, S. J.
A1  - Pignol, C.
A1  - Piotrowska, N.
A1  - Poli, M-S
A1  - Prokopenko, A.
A1  - Schwanck, F.
A1  - Stepanek, C.
A1  - Swann, G. E. A.
A1  - Telford, R.
A1  - Thomas, E.
A1  - Thomas, Z.
A1  - Truebe, S.
A1  - von Gunten, L.
A1  - Waite, A.
A1  - Weitzel, N.
A1  - Wilhelm, B.
A1  - Williams, J.
A1  - Winstrup, M.
A1  - Zhao, N.
A1  - Zhou, Y.
T1  - PaCTS 1.0: A Crowdsourced Reporting Standard for Paleoclimate Data
JF  - Paleoceanography and paleoclimatology
N2  - The progress of science is tied to the standardization of measurements, instruments, and data. This is especially true in the Big Data age, where analyzing large data volumes critically hinges on the data being standardized. Accordingly, the lack of community-sanctioned data standards in paleoclimatology has largely precluded the benefits of Big Data advances in the field. Building upon recent efforts to standardize the format and terminology of paleoclimate data, this article describes the Paleoclimate Community reporTing Standard (PaCTS), a crowdsourced reporting standard for such data. PaCTS captures which information should be included when reporting paleoclimate data, with the goal of maximizing the reuse value of paleoclimate data sets, particularly for synthesis work and comparison to climate model simulations. Initiated by the LinkedEarth project, the process to elicit a reporting standard involved an international workshop in 2016, various forms of digital community engagement over the next few years, and grassroots working groups. Participants in this process identified important properties across paleoclimate archives, in addition to the reporting of uncertainties and chronologies; they also identified archive-specific properties and distinguished reporting standards for new versus legacy data sets. This work shows that at least 135 respondents overwhelmingly support a drastic increase in the amount of metadata accompanying paleoclimate data sets. Since such goals are at odds with present practices, we discuss a transparent path toward implementing or revising these recommendations in the near future, using both bottom-up and top-down approaches.
KW  - standards
KW  - FAIR
KW  - paleoclimate
KW  - paleoceanography
KW  - data
KW  - best practices
Y1  - 2019
U6  - https://doi.org/10.1029/2019PA003632
SN  - 2572-4517
SN  - 2572-4525
VL  - 34
IS  - 10
SP  - 1570
EP  - 1596
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Merz, Bruno
A1  - Aerts, Jeroen C. J. H.
A1  - Arnbjerg-Nielsen, Karsten
A1  - Baldi, M.
A1  - Becker, Andrew C.
A1  - Bichet, A.
A1  - Bloeschl, G.
A1  - Bouwer, Laurens M.
A1  - Brauer, Achim
A1  - Cioffi, F.
A1  - Delgado, Jose Miguel Martins
A1  - Gocht, M.
A1  - Guzzetti, F.
A1  - Harrigan, S.
A1  - Hirschboeck, K.
A1  - Kilsby, C.
A1  - Kron, W.
A1  - Kwon, H. -H.
A1  - Lall, U.
A1  - Merz, R.
A1  - Nissen, K.
A1  - Salvatti, P.
A1  - Swierczynski, Tina
A1  - Ulbrich, U.
A1  - Viglione, A.
A1  - Ward, P. J.
A1  - Weiler, M.
A1  - Wilhelm, B.
A1  - Nied, Manuela
T1  - Floods and climate: emerging perspectives for flood risk assessment and management
JF  - Natural hazards and earth system sciences
N2  - Flood estimation and flood management have traditionally been the domain of hydrologists, water resources engineers and statisticians, and disciplinary approaches abound. Dominant views have been shaped; one example is the catchment perspective: floods are formed and influenced by the interaction of local, catchment-specific characteristics, such as meteorology, topography and geology. These traditional views have been beneficial, but they have a narrow framing. In this paper we contrast traditional views with broader perspectives that are emerging from an improved understanding of the climatic context of floods. We come to the following conclusions: (1) extending the traditional system boundaries (local catchment, recent decades, hydrological/hydraulic processes) opens up exciting possibilities for better understanding and improved tools for flood risk assessment and management. (2) Statistical approaches in flood estimation need to be complemented by the search for the causal mechanisms and dominant processes in the atmosphere, catchment and river system that leave their fingerprints on flood characteristics. (3) Natural climate variability leads to time-varying flood characteristics, and this variation may be partially quantifiable and predictable, with the perspective of dynamic, climate-informed flood risk management. (4) Efforts are needed to fully account for factors that contribute to changes in all three risk components (hazard, exposure, vulnerability) and to better understand the interactions between society and floods. (5) Given the global scale and societal importance, we call for the organization of an international multidisciplinary collaboration and data-sharing initiative to further understand the links between climate and flooding and to advance flood research.
Y1  - 2014
U6  - https://doi.org/10.5194/nhess-14-1921-2014
SN  - 1561-8633
VL  - 14
IS  - 7
SP  - 1921
EP  - 1942
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - GEN
A1  - Müller-Schöll, A.
A1  - Klopp-Schulze, Lena
A1  - Huisinga, Wilhelm
A1  - Jörger, M.
A1  - Neven, P.
A1  - Koolen, S. L.
A1  - Mathijssen, R. H. J.
A1  - Schmidt, S.
A1  - Kloft, Charlotte
T1  - Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach
T2  - Annals of Oncology
Y1  - 2019
SN  - 0923-7534
SN  - 1569-8041
VL  - 30
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Mueller-Schoell, Anna
A1  - Groenland, Stefanie L.
A1  - Scherf-Clavel, Oliver
A1  - van Dyk, Madele
A1  - Huisinga, Wilhelm
A1  - Michelet, Robin
A1  - Jaehde, Ulrich
A1  - Steeghs, Neeltje
A1  - Huitema, Alwin D. R.
A1  - Kloft, Charlotte
T1  - Therapeutic drug monitoring of oral targeted antineoplastic drugs
JF  - European journal of clinical pharmacology
N2  - Purpose This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the pharmacokinetic exposure in OAD therapy are depicted together with an overview of different TDM approaches. Finally, current evidence for TDM for all approved OADs is reviewed. Methods A comprehensive literature search (covering literature published until April 2020), including primary and secondary scientific literature on pharmacokinetics and dose individualisation strategies for OADs, together with US FDA Clinical Pharmacology and Biopharmaceutics Reviews and the Committee for Medicinal Products for Human Use European Public Assessment Reports was conducted. Results OADs are highly potent drugs, which have substantially changed treatment options for cancer patients. Nevertheless, high pharmacokinetic variability and low treatment adherence are risk factors for treatment failure. TDM is a powerful tool to individualise drug dosing, ensure drug concentrations within the therapeutic window and increase treatment success rates. After reviewing the literature for 71 approved OADs, we show that exposure-response and/or exposure-toxicity relationships have been established for the majority. Moreover, TDM has been proven to be feasible for individualised dosing of abiraterone, everolimus, imatinib, pazopanib, sunitinib and tamoxifen in prospective studies. There is a lack of experience in how to best implement TDM as part of clinical routine in OAD cancer therapy. Conclusion Sub-therapeutic concentrations and severe adverse events are current challenges in OAD treatment, which can both be addressed by the application of TDM-guided dosing, ensuring concentrations within the therapeutic window.
KW  - targeted antineoplastic drugs
KW  - tyrosine kinase inhibitors
KW  - therapeutic
KW  - drug monitoring
KW  - oral anticancer drugs
KW  - personalised medicine
Y1  - 2020
U6  - https://doi.org/10.1007/s00228-020-03014-8
SN  - 0031-6970
SN  - 1432-1041
VL  - 77
IS  - 4
SP  - 441
EP  - 464
PB  - Springer
CY  - Heidelberg
ER  -