TY  - JOUR
A1  - Breuer, Elmar
A1  - Mikelskis, Helmut
A1  - Otto, R.
A1  - Schülbe, R.
A1  - Wenzel, M.
A1  - Wilke, Hans-Joachim
ED  - Mikelskis, Helmut
T1  - Physik : Kl. 9/10, Lehrerbd., Gymnasium Berlin
Y1  - 2002
SN  - 3-06-022235-5
PB  - Volk-und-Wissen-Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Dubreuil, R. R.
A1  - Grushko, T.
A1  - Baumann, Otto
T1  - Differential effects of a labial mutation on the development, structure, and function of stomach acid-secreting cells in Drosophila larvae and adults
Y1  - 2001
ER  - 
TY  - JOUR
A1  - Scheible, W. R.
A1  - Törjék, Otto
A1  - Altmann, Thomas
T1  - From markers to cloned genes : map based cloning
Y1  - 2004
SN  - 3-540-20689-2
ER  - 
TY  - JOUR
A1  - Dames, Petra
A1  - Schmidt, R.
A1  - Walz, Bernd
A1  - Baumann, Otto
T1  - Regulation of vacuolar-type H+-ATPase (vATPase) in blowfly salivary glands
Y1  - 2004
SN  - 0171-9335
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Törjek, Otto
A1  - Berger, Dieter
A1  - Meyer, Rhonda C.
A1  - Müssig, Carsten
A1  - Schmidt, K. J.
A1  - Sorensen, T. R.
A1  - Weisshaar, Bernd
A1  - Olds-Mitchell, T.
T1  - Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Altmann, Thomas
A1  - Schmid, K. J.
A1  - Sörensen, Rossleff T.
A1  - Stracke, R.
A1  - Törjek, Otto
A1  - Mitchel-Olds, T.
A1  - Weisshaar, Bernd
T1  - Large-scale identification and analysis of genome-wide single-nucleotide polymorphisms for mapping in Arabidopsis thaliana
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Von Raab-Straube, Eckhard
A1  - Raus, Thomas
A1  - Bazos, Ioannis
A1  - Cornec, J. P.
A1  - De Belair, Gerard.
A1  - Dimitrakopoulos, P. G.
A1  - El Mokni, Ridha
A1  - Fateryga, Alexander V.
A1  - Fateryga, Valentina V.
A1  - Fridlender, Alain
A1  - Gil, Jaime
A1  - Grigorenko, V. N.
A1  - Hand, Ralf
A1  - Kovalchuk, A.
A1  - Mastrogianni, A.
A1  - Otto, R.
A1  - Rätzel, Stefan
A1  - Raus, Th.
A1  - Ristow, Michael
A1  - Salas Pascual, M.
A1  - Strid, Arne
A1  - Svirin, S. A.
A1  - Tsiripidis, Ioannis.
A1  - Uhlich, Holger
A1  - Vela, Errol
A1  - Verloove, Filip
A1  - Vidakis, K.
A1  - Yena, Andriy Vasylyovych
A1  - Yevseyenkov, P. E.
A1  - Zeddam, A.
T1  - Euro plus Med-Checklist Notulae, 11
JF  - Willdenowia
N2  - This is the eleventh of a series of miscellaneous contributions, by various authors, where hitherto unpublished data relevant to both the Med-Checklist and the Euro+Med (or Sisyphus) projects are presented. This instalment deals with the families Anacardiaceae, Asparagaceae (incl. Hyacinthaceae), Bignoniaceae, Cactaceae, Compositae, Cruciferae, Cyperaceae, Ericaceae, Gramineae, Labiatae, Leguminosae, Orobanchaceae, Polygonaceae, Rosaceae, Solanaceae and Staphyleaceae. It includes new country and area records and taxonomic and distributional considerations for taxa in Bidens, Campsis, Centaurea, Cyperus, Drymocallis, Engem, Hoffmannseggia, Hypopitys, Lavandula, Lithraea, Melilotus, Nicotiana, Olimarabidopsis, Opuntia, Orobanche, Phelipanche, Phragmites, Rumex, Salvia, Schinus, Staphylea, and a new combination in Drimia.
KW  - distribution
KW  - Euro plus Med PlantBase
KW  - Europe
KW  - Med-Checklist
KW  - Mediterranean
KW  - new combination
KW  - new record
KW  - taxonomy
KW  - vascular plants
Y1  - 2019
U6  - https://doi.org/10.3372/wi.49.49312
SN  - 0511-9618
VL  - 49
IS  - 3
SP  - 421
EP  - 445
PB  - Botanischer Garten & botanisches Museum Berlin-Dahlem
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Minichmayr, Iris K.
A1  - Roberts, Jason A.
A1  - Frey, Otto R.
A1  - Roehr, Anka C.
A1  - Kloft, Charlotte
A1  - Brinkmann, Alexander
T1  - Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model
JF  - Journal of Antimicrobial Chemotherapy
N2  - Background: Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success in ICU patients. Objectives: To develop and externally validate a population pharmacokinetic model for continuous-infusion meropenem in critically ill patients and to establish a nomogram based on a routinely available marker of renal function. Methods: A population pharmacokinetic model was developed in NONMEM (R) 7.3 based on steady-state meropenem concentrations (C-ss) collected during therapeutic drug monitoring. Different serum creatinine-based markers of renal function were compared for their influence on meropenem clearance (the Cockcroft-Gault creatinine clearance CLCRcG, the CLCR bedside estimate according to Jelliffe, the Chronic Kidney Disease Epidemiology Collaboration equation and the four-variable Modification of Diet in Renal Disease equation). After validation of the pharmacokinetic model with independent data, a dosing nomogram was developed, relating renal function to the daily doses required to achieve selected target concentrations (4/8/16 mg/L) in 90% of the patients. Probability of target attainment was determined for efficacy (C-ss >= 8 mg/L) and potentially increased likelihood of adverse drug reactions (C-ss >32 mg/L). Results: In total, 433 plasma concentrations (3.20-48.0 mg/L) from 195 patients (median/P-0.05 - P-0.95 at baseline: weight 77.0/55.0-114 kg, CLCRCG 63.0/19.6-168 mL/min) were used for model building. We found that CLCRCG best described meropenem clearance (CL = 7.71 L/h, CLCRCG = 80 mL/min). The developed model was successfully validated with external data (n = 171, 73 patients). According to the nomogram, daily doses of 910/1480/2050/2800/ 3940 mg were required to reach a target C-ss = 8 mg/L in 90% of patients with CLCRCG = 20/50/80/120/180 mL/min, respectively. A low probability of adverse drug reactions (<0.5%) was associated with these doses. Conclusions: A dosing nomogram was developed for continuous-infusion meropenem based on renal function in a critically ill population.
Y1  - 2018
U6  - https://doi.org/10.1093/jac/dkx526
SN  - 0305-7453
SN  - 1460-2091
VL  - 73
IS  - 5
SP  - 1330
EP  - 1339
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Otto, Katharina Alexandra
A1  - Jaumann, R.
A1  - Krohn, K.
A1  - Spahn, Frank
A1  - Raymond, C. A.
A1  - Russell, C. T.
T1  - The Coriolis effect on mass wasting during the Rheasilvia impact on asteroid Vesta
JF  - Geophysical research letters
N2  - We investigate the influence of the Coriolis force on mass motion related to the Rheasilvia impact on asteroid Vesta. Observations by the NASA Dawn mission revealed a pattern of curved radial ridges, which are related to Coriolis-deflected mass-wasting during the initial modification stage of the crater. Utilizing the projected curvature of the mass-wasting trajectories, we developed a method that enabled investigation of the initial mass wasting of the Rheasilvia impact by observational means. We demonstrate that the Coriolis force can strongly affect the crater formation processes on rapidly rotating objects, and we derive the material's velocities (28.9 ± 22.5 m/s), viscosities (1.5–9.0 × 106 Pa s) and coefficients of friction (0.02–0.81) during the impact modification stage. The duration of the impact modification stage could be estimated to (1.1 ± 0.5) h. By analyzing the velocity distribution with respect to the topography, we deduce that the Rheasilvia impactor hit a heterogeneous target and that the initial crater walls were significantly steeper during the modification stage.
Y1  - 2016
U6  - https://doi.org/10.1002/2016GL071539
SN  - 0094-8276
SN  - 1944-8007
VL  - 43
SP  - 12340
EP  - 12347
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Grott, Matthias
A1  - Knollenberg, J.
A1  - Hamm, M.
A1  - Ogawa, K.
A1  - Jaumann, R.
A1  - Otto, Katharina Alexandra
A1  - Delbo, M.
A1  - Michel, Patrick
A1  - Biele, J.
A1  - Neumann, Wladimir
A1  - Knapmeyer, Martin
A1  - Kührt, E.
A1  - Senshu, H.
A1  - Okada, T.
A1  - Helbert, Jorn
A1  - Maturilli, A.
A1  - Müller, N.
A1  - Hagermann, A.
A1  - Sakatani, Naoya
A1  - Tanaka, S.
A1  - Arai, T.
A1  - Mottola, Stefano
A1  - Tachibana, Shogo
A1  - Pelivan, Ivanka
A1  - Drube, Line
A1  - Vincent, J-B
A1  - Yano, Hajime
A1  - Pilorget, C.
A1  - Matz, K. D.
A1  - Schmitz, N.
A1  - Koncz, A.
A1  - Schröder, Stefan E.
A1  - Trauthan, F.
A1  - Schlotterer, Markus
A1  - Krause, C.
A1  - Ho, T-M
A1  - Moussi-Soffys, A.
T1  - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF  - Nature astronomy
N2  - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7
Y1  - 2019
U6  - https://doi.org/10.1038/s41550-019-0832-x
SN  - 2397-3366
VL  - 3
IS  - 11
SP  - 971
EP  - 976
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Grott, Matthias
A1  - Knollenberg, J.
A1  - Hamm, M.
A1  - Ogawa, K.
A1  - Jaumann, R.
A1  - Otto, Katharina Alexandra
A1  - Delbo, M.
A1  - Michel, P.
A1  - Biele, J.
A1  - Neumann, W.
A1  - Knapmeyer, M.
A1  - Kuehrt, E.
A1  - Senshu, H.
A1  - Okada, T.
A1  - Helbert, J.
A1  - Maturilli, A.
A1  - Müller, N.
A1  - Hagermann, A.
A1  - Sakatani, N.
A1  - Tanaka, S.
A1  - Arai, T.
A1  - Mottola, S.
A1  - Tachibana, S.
A1  - Pelivan, Ivanka
A1  - Drube, L.
A1  - Vincent, J-B
A1  - Yano, H.
A1  - Pilorget, C.
A1  - Matz, K. D.
A1  - Schmitz, N.
A1  - Koncz, A.
A1  - Schröder, S. E.
A1  - Trauthan, F.
A1  - Schlotterer, M.
A1  - Krause, C.
A1  - Ho, T-M
A1  - Moussi-Soffys, A.
T1  - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF  - Nature astronomy
N2  - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.
Y1  - 2020
U6  - https://doi.org/10.1038/s41550-019-0832-x
SN  - 2397-3366
VL  - 3
IS  - 11
SP  - 971
EP  - 976
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Bresnick, Anne R.
A1  - Wolff-Long, Vicki L.
A1  - Baumann, Otto
A1  - Pollard, Thomas D.
T1  - Phosphorylation of threonine-18 of the regulatory light chain dissociates the ATPase and motor properties of smooth muscle myosin II
Y1  - 1995
SN  - 006-2960
ER  - 
TY  - JOUR
A1  - Malinova, Irina
A1  - Alseekh, Saleh
A1  - Feil, Regina
A1  - Fernie, Alisdair R.
A1  - Baumann, Otto
A1  - Schoettler, Mark Aurel
A1  - Lunn, John Edward
A1  - Fettke, Jörg
T1  - Starch Synthase 4 and Plastidal Phosphorylase Differentially Affect Starch Granule Number and Morphology
JF  - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants
N2  - The process of starch granule formation in leaves of Arabidopsis ( Arabidopsis thaliana) is obscure. Besides STARCH SYNTHASE4 (SS4), the PLASTIDIAL PHOSPHORYLASE (PHS1) also seems to be involved, since dpe2-1/phs1a double mutants lacking both PHS1 and the cytosolic DISPROPORTIONATING ENZYME2 (DPE2) displayed only one starch granule per chloroplast under normal growth conditions. For further studies, a dpe2-1/phs1a/ss4 triple mutant and various combinations of double mutants were generated and metabolically analyzed with a focus on starch metabolism. The dpe2-1/phs1a/ ss4 mutant revealed a massive starch excess phenotype. Furthermore, these plants grown under 12 h of light/12 h of dark harbored a single large and spherical starch granule per plastid. The number of starch granules was constant when the light/dark regime was altered, but this was not observed in the parental lines. With regard to growth, photosynthetic parameters, and metabolic analyses, the triple mutant additionally displayed alterations in comparison with ss4 and dpe21/phs1a. The results clearly illustrate that PHS1 and SS4 are differently involved in starch granule formation and do not act in series. However, SS4 appears to exert a stronger influence. In connection with the characterized double mutants, we discuss the generation of starch granules and the observed formation of spherical starch granules.
Y1  - 2017
U6  - https://doi.org/10.1104/pp.16.01859
SN  - 0032-0889
SN  - 1532-2548
VL  - 174
SP  - 73
EP  - 85
PB  - American Society of Plant Physiologists
CY  - Rockville
ER  - 
TY  - JOUR
A1  - Malinova, Irina
A1  - Mahlow, Sebastian
A1  - Alseekh, Saleh
A1  - Orawetz, Tom
A1  - Fernie, Alisdair R.
A1  - Baumann, Otto
A1  - Steup, Martin
A1  - Fettke, Jörg
T1  - Double knockout mutants of arabidopsis grown under normal conditions reveal that the plastidial phosphorylase isozyme participates in transitory starch metabolism
JF  - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants
N2  - In leaves of two starch-related single-knockout lines lacking either the cytosolic transglucosidase (also designated as disproportionating enzyme 2, DPE2) or the maltose transporter (MEX1), the activity of the plastidial phosphorylase isozyme (PHS1) is increased. In both mutants, metabolism of starch-derived maltose is impaired but inhibition is effective at different subcellular sites. Two constitutive double knockout mutants were generated (designated as dpe2-1 x phs1a and mex1 x phs1b) both lacking functional PHS1. They reveal that in normally grown plants, the plastidial phosphorylase isozyme participates in transitory starch degradation and that the central carbon metabolism is closely integrated into the entire cell biology. All plants were grown either under continuous illumination or in a light-dark regime. Both double mutants were compromised in growth and, compared with the single knockout plants, possess less average leaf starch when grown in a light-dark regime. Starch and chlorophyll contents decline with leaf age. As revealed by transmission electron microscopy, mesophyll cells degrade chloroplasts, but degradation is not observed in plants grown under continuous illumination. The two double mutants possess similar but not identical phenotypes. When grown in a light-dark regime, mesophyll chloroplasts of dpe2-1 x phs1a contain a single starch granule but under continuous illumination more granules per chloroplast are formed. The other double mutant synthesizes more granules under either growth condition. In continuous light, growth of both double mutants is similar to that of the parental single knockout lines. Metabolite profiles and oligoglucan patterns differ largely in the two double mutants.
Y1  - 2014
U6  - https://doi.org/10.1104/pp.113.227843
SN  - 0032-0889
SN  - 1532-2548
VL  - 164
IS  - 2
SP  - 907
EP  - 921
PB  - American Society of Plant Physiologists
CY  - Rockville
ER  -