TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - GEN
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Backes, Michael
A1  - Balenderan, Shangkari
A1  - Balzer, Arnim
A1  - Barnacka, Anna
A1  - Becherini, Yvonne
A1  - Tjus, Julia Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, Konrad
A1  - Birsin, E.
A1  - Biteau, Jonathan
A1  - Böttcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Carrigan, Svenja
A1  - Casanova, Sabrina
A1  - Chadwick, Paula M.
A1  - Chakraborty, Nachiketa
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Conrad, Jan
A1  - Couturier, Claire
A1  - Cui, Yudong
A1  - Davids, Isak Delberth
A1  - Degrange, Bernhard
A1  - Deil, Christoph
A1  - deWilt, P.
A1  - Djannati-Ataï, A.
A1  - Domainko, Wilfried
A1  - Donath, Axel
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, Tanya
A1  - Egberts, Kathrin
A1  - Eger, Peter
A1  - Espigat, P.
A1  - Farnier, C.
A1  - Fegan, Stephen
A1  - Feinstein, Fabrice
A1  - Fernandes, Milton Virgilio
A1  - Fernandez, Diane
A1  - Fiasson, A.
A1  - Fontaine, Gerard
A1  - Förster, Andreas
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Yves A.
A1  - Garrigoux, Tania
A1  - Giavitto, G.
A1  - Giebels, Berrie
A1  - Glicenstein, Jean-Francois
A1  - Gottschall, Daniel
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, Daniela
A1  - Haeffner, S.
A1  - Hahn, Joachim
A1  - Harris, Jonathan
A1  - Heinzelmann, Götz
A1  - Henri, G.
A1  - Hermann, German
A1  - Hervet, O.
A1  - Hillert, Andreas
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hofverberg, Petter
A1  - Holler, Markus
A1  - Horns, Dieter
A1  - Ivascenko, Alex
A1  - Jacholkowska, A.
A1  - Jahn, C.
A1  - Jamrozy, Marek
A1  - Janiak, M.
A1  - Jankowsky, F.
A1  - Jung-Richardt, I.
A1  - Kastendieck, Max Anton
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Kaufmann, S.
A1  - Khelifi, B.
A1  - Kieffer, Michel
A1  - Klepser, S.
A1  - Klochkov, Dmitry
A1  - Kluzniak, W.
A1  - Kolitzus, David
A1  - Komin, Nu
A1  - Kosack, Karl
A1  - Krakau, Steffen
A1  - Krayzel, F.
A1  - Krueger, Pat P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lefaucheur, J.
A1  - Lefranc, Valentin
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Lohse, Thomas
A1  - Lopatin, A.
A1  - Lu, Chia-Chun
A1  - Marandon, Vincent
A1  - Marcowith, Alexandre
A1  - Marx, Ramin
A1  - Maurin, G.
A1  - Maxted, Nigel
A1  - Mayer, Michael
A1  - McComb, T. J. Lowry
A1  - Mehault, J.
A1  - Meintjes, P. J.
A1  - Menzler, Ulf
A1  - Meyer, M.
A1  - Mitchell, Alison M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, Thomas
A1  - de Naurois, Mathieu
A1  - Niemiec, J.
A1  - Nolan, Sam J.
A1  - Oakes, Louise
A1  - Odaka, Hirokazu
A1  - Ohm, S.
A1  - Optiz, Björn
A1  - Ostrowski, Michal
A1  - Oya, I.
A1  - Panter, Michael
A1  - Parsons, R. Daniel
A1  - Arribas, M. Paz
A1  - Pekeur, Nikki W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, Helen
A1  - Pühlhofer, Gerd
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reichardt, I.
A1  - Reimer, Anita
A1  - Reimer, Olaf
A1  - Renaud, Metz
A1  - de los Reyes, Raquel
A1  - Rieger, Frank
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, Vardan
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, Andrea
A1  - Schlickeiser, Reinhard
A1  - Schuessler, F.
A1  - Schulz, A.
A1  - Schwanke, Ullrich
A1  - Schwarzburg, S.
A1  - Schwemmer, S.
A1  - Sol, H.
A1  - Spanier, Felix
A1  - Spengler, G.
A1  - Spies, Franziska
A1  - Stawarz, Lukasz
A1  - Steenkamp, Riaan
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, Martin
A1  - Trichard, C.
A1  - Valerius, K.
A1  - van Eldik, C.
A1  - van Soelen, B.
A1  - Vasileiadis, Georges
A1  - Veh, J.
A1  - Venter, Christo
A1  - Viana, Aion
A1  - Vincent, P.
A1  - Vink, Jacco
A1  - Völk, Heinrich J.
A1  - Volpe, Francesca
A1  - Vorster, Martine
A1  - Vuillaume, T.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - Ward, Martin
A1  - Weidinger, Matthias
A1  - Weitzel, Quirin
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, Ruizhi
A1  - Zabalza, Victor
A1  - Zaborov, Dmitry
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zechlin, Hannes -S.
T1  - H.E.S.S. detection of TeV emission from the interaction region between the supernova remnant G349.7+0.2 and a molecular cloud (vol 574, A100, 2015)
T2  - Astronomy and astrophysics : an international weekly journal
KW  - gamma rays: general
KW  - ISM: supernova remnants
KW  - ISM: clouds
KW  - errata, addenda
Y1  - 2015
U6  - https://doi.org/10.1051/0004-6361/201425070e
SN  - 1432-0746
VL  - 580
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Cochard, Roland
A1  - Edwards, Peter J.
A1  - Weber, Ewald
T1  - Post-ranching tree-grass interactions in secondary Acacia zanzibarica woodlands in coastal Tanzania - an experimental study
JF  - Applied vegetation science : official organ of the International Association for Vegetation Science
N2  - Questions: We studied a humid savanna rangeland., abandoned in 2000, where intensive cattle grazing had led to widespread encroachment by Acacia zanzibarica. We asked whether the acacia trees were able to regenerate in the absence of domesJic livestock, either beneath acacia canopies or in artificial clearings.
 Location: Tropical coastal Tanzania (former Mkwaja Ranch, now in Saadani National Park).
 Methods: We set out a total of 48 plots on four sites in November 2001, and assigned them to three treatments: trees felled (FN), trees felled and the stumps poisoned (FP) with Triclopyr, and no intervention (controls, NN). We analysed soils of plots for texture and nutrients. In two wet (July 2002 and 2003) and one dry (February 2003) seasons we assessed grass and tree leaf biomass and transpiration rates, and counted acacia seedlings and resprouts. The effects of treatments (controlled for site and other co-variables) on grass growth and acacia rectaiitment were determined statistically using general linear models (GLM).
 Results: Acacia leaves had a much higher stomatal conductance than grasses, with the consequence that total evapotranspiration in woodland was higher than in clearings. In the wet seasons, grass biomass and seedling densities were significantly higher in clearings than in control plots, which we attributed to more.favourable moisture conditions, In the dry season, by contrast, we found no differences, and all seedlings had died. On FN plots, 71% of stumps, and on FP plots, 11% resprouted (coppicing), but only a quarter of these shoots survived until July 2003. Root suckering occurred spontaneously at low densities. No root suckers or resprouts grew beyond the grass layer.
 Conclusions: Acacia woodlands do not regenerate in the absence of cattle grazing, and tree cutting in combination with appropriate fire management could potentially accelerate re-establishment of open grassland. However, regeneration might occur in the future due to the increasing wildlife populations within the new national park.
KW  - Bush encroachment
KW  - Clearing formation
KW  - Grass flush
KW  - Savanna rangeland dynamics
KW  - Sprouting
KW  - Tree recruitment
Y1  - 2015
U6  - https://doi.org/10.1111/avsc.12134
SN  - 1402-2001
SN  - 1654-109X
VL  - 18
IS  - 2
SP  - 297
EP  - 310
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Hoehn, Richard S.
A1  - Jernigan, Peter L.
A1  - Japtok, Lukasz
A1  - Chang, Alex L.
A1  - Midura, Emily F.
A1  - Caldwell, Charles C.
A1  - Kleuser, Burkhard
A1  - Lentsch, Alex B.
A1  - Edwards, Michael J.
A1  - Gulbins, Erich
A1  - Pritts, Timothy A.
T1  - Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflammation
JF  - Annals of surgery : a monthly review of surgical science and practice
N2  - Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion.
Summary Background Data: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion.
Methods: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units.
Results: Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles. Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and microparticle production during pRBC storage. Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation. This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice.
Conclusions: Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood.
KW  - acid sphingomyelinase
KW  - blood banking
KW  - ceramide
KW  - lung inflammation
KW  - microparticle
Y1  - 2017
U6  - https://doi.org/10.1097/SLA.0000000000001648
SN  - 0003-4932
SN  - 1528-1140
VL  - 265
IS  - 1
SP  - 218
EP  - 226
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - GEN
A1  - Battarbee, Richard W.
A1  - Lamb, Henry F.
A1  - Bennett, Keith
A1  - Edwards, Mary
A1  - Bjune, Anne E.
A1  - Kaland, Peter E.
A1  - Berglund, Björn E.
A1  - Lotter, André F.
A1  - Seppä, Heikki
A1  - Willis, Kathy J.
A1  - Herzschuh, Ulrike
A1  - Birks, Hilary H.
T1  - John Birks
BT  - pioneer in quantitative palaeoecology
T2  - The Holocene
N2  - We describe the career of John Birks as a pioneering scientist who has, over a career spanning five decades, transformed palaeoecology from a largely descriptive to a rigorous quantitative science relevant to contemporary questions in ecology and environmental change. We review his influence on students and colleagues not only at Cambridge and Bergen Universities, his places of primary employment, but also on individuals and research groups in Europe and North America. We also introduce the collection of papers that we have assembled in his honour. The papers are written by his former students and close colleagues and span many of the areas of palaeoecology to which John himself has made major contributions. These include the relationship between ecology and palaeoecology, late-glacial and Holocene palaeoecology, ecological succession, climate change and vegetation history, the role of palaeoecological techniques in reconstructing and understanding the impact of human activity on terrestrial and freshwater ecosystems and numerical analysis of multivariate palaeoecological data.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 420 
KW  - climate change
KW  - ecosystem history
KW  - Holocene
KW  - late-glacial
KW  - numerical data analysis
KW  - palaeoecology
KW  - palaeolimnology
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404544
ER  - 
TY  - JOUR
A1  - Mantzouki, Evanthia
A1  - Campbell, James
A1  - van Loon, Emiel
A1  - Visser, Petra
A1  - Konstantinou, Iosif
A1  - Antoniou, Maria
A1  - Giuliani, Gregory
A1  - Machado-Vieira, Danielle
A1  - de Oliveira, Alinne Gurjao
A1  - Maronic, Dubravka Spoljaric
A1  - Stevic, Filip
A1  - Pfeiffer, Tanja Zuna
A1  - Vucelic, Itana Bokan
A1  - Zutinic, Petar
A1  - Udovic, Marija Gligora
A1  - Plenkovic-Moraj, Andelka
A1  - Tsiarta, Nikoletta
A1  - Blaha, Ludek
A1  - Geris, Rodan
A1  - Frankova, Marketa
A1  - Christoffersen, Kirsten Seestern
A1  - Warming, Trine Perlt
A1  - Feldmann, Tonu
A1  - Laas, Alo
A1  - Panksep, Kristel
A1  - Tuvikene, Lea
A1  - Kangro, Kersti
A1  - Haggqvist, Kerstin
A1  - Salmi, Pauliina
A1  - Arvola, Lauri
A1  - Fastner, Jutta
A1  - Straile, Dietmar
A1  - Rothhaupt, Karl-Otto
A1  - Fonvielle, Jeremy Andre
A1  - Grossart, Hans-Peter
A1  - Avagianos, Christos
A1  - Kaloudis, Triantafyllos
A1  - Triantis, Theodoros
A1  - Zervou, Sevasti-Kiriaki
A1  - Hiskia, Anastasia
A1  - Gkelis, Spyros
A1  - Panou, Manthos
A1  - McCarthy, Valerie
A1  - Perello, Victor C.
A1  - Obertegger, Ulrike
A1  - Boscaini, Adriano
A1  - Flaim, Giovanna
A1  - Salmaso, Nico
A1  - Cerasino, Leonardo
A1  - Koreiviene, Judita
A1  - Karosiene, Jurate
A1  - Kasperoviciene, Jurate
A1  - Savadova, Ksenija
A1  - Vitonyte, Irma
A1  - Haande, Sigrid
A1  - Skjelbred, Birger
A1  - Grabowska, Magdalena
A1  - Karpowicz, Maciej
A1  - Chmura, Damian
A1  - Nawrocka, Lidia
A1  - Kobos, Justyna
A1  - Mazur-Marzec, Hanna
A1  - Alcaraz-Parraga, Pablo
A1  - Wilk-Wozniak, Elzbieta
A1  - Krzton, Wojciech
A1  - Walusiak, Edward
A1  - Gagala, Ilona
A1  - Mankiewicz-Boczek, Joana
A1  - Toporowska, Magdalena
A1  - Pawlik-Skowronska, Barbara
A1  - Niedzwiecki, Michal
A1  - Peczula, Wojciech
A1  - Napiorkowska-Krzebietke, Agnieszka
A1  - Dunalska, Julita
A1  - Sienska, Justyna
A1  - Szymanski, Daniel
A1  - Kruk, Marek
A1  - Budzynska, Agnieszka
A1  - Goldyn, Ryszard
A1  - Kozak, Anna
A1  - Rosinska, Joanna
A1  - Szelag-Wasielewska, Elzbieta
A1  - Domek, Piotr
A1  - Jakubowska-Krepska, Natalia
A1  - Kwasizur, Kinga
A1  - Messyasz, Beata
A1  - Pelechata, Aleksandra
A1  - Pelechaty, Mariusz
A1  - Kokocinski, Mikolaj
A1  - Madrecka, Beata
A1  - Kostrzewska-Szlakowska, Iwona
A1  - Frak, Magdalena
A1  - Bankowska-Sobczak, Agnieszka
A1  - Wasilewicz, Michal
A1  - Ochocka, Agnieszka
A1  - Pasztaleniec, Agnieszka
A1  - Jasser, Iwona
A1  - Antao-Geraldes, Ana M.
A1  - Leira, Manel
A1  - Hernandez, Armand
A1  - Vasconcelos, Vitor
A1  - Morais, Joao
A1  - Vale, Micaela
A1  - Raposeiro, Pedro M.
A1  - Goncalves, Vitor
A1  - Aleksovski, Boris
A1  - Krstic, Svetislav
A1  - Nemova, Hana
A1  - Drastichova, Iveta
A1  - Chomova, Lucia
A1  - Remec-Rekar, Spela
A1  - Elersek, Tina
A1  - Delgado-Martin, Jordi
A1  - Garcia, David
A1  - Luis Cereijo, Jose
A1  - Goma, Joan
A1  - Carmen Trapote, Mari
A1  - Vegas-Vilarrubia, Teresa
A1  - Obrador, Biel
A1  - Garcia-Murcia, Ana
A1  - Real, Monserrat
A1  - Romans, Elvira
A1  - Noguero-Ribes, Jordi
A1  - Parreno Duque, David
A1  - Fernandez-Moran, Elisabeth
A1  - Ubeda, Barbara
A1  - Angel Galvez, Jose
A1  - Marce, Rafael
A1  - Catalan, Nuria
A1  - Perez-Martinez, Carmen
A1  - Ramos-Rodriguez, Eloisa
A1  - Cillero-Castro, Carmen
A1  - Moreno-Ostos, Enrique
A1  - Maria Blanco, Jose
A1  - Rodriguez, Valeriano
A1  - Juan Montes-Perez, Jorge
A1  - Palomino, Roberto L.
A1  - Rodriguez-Perez, Estela
A1  - Carballeira, Rafael
A1  - Camacho, Antonio
A1  - Picazo, Antonio
A1  - Rochera, Carlos
A1  - Santamans, Anna C.
A1  - Ferriol, Carmen
A1  - Romo, Susana
A1  - Soria, Juan Miguel
A1  - Hansson, Lars-Anders
A1  - Urrutia-Cordero, Pablo
A1  - Ozen, Arda
A1  - Bravo, Andrea G.
A1  - Buck, Moritz
A1  - Colom-Montero, William
A1  - Mustonen, Kristiina
A1  - Pierson, Don
A1  - Yang, Yang
A1  - Verspagen, Jolanda M. H.
A1  - Domis, Lisette N. de Senerpont
A1  - Seelen, Laura
A1  - Teurlincx, Sven
A1  - Verstijnen, Yvon
A1  - Lurling, Miquel
A1  - Maliaka, Valentini
A1  - Faassen, Elisabeth J.
A1  - Latour, Delphine
A1  - Carey, Cayelan C.
A1  - Paerl, Hans W.
A1  - Torokne, Andrea
A1  - Karan, Tunay
A1  - Demir, Nilsun
A1  - Beklioglu, Meryem
A1  - Filiz, Nur
A1  - Levi, Eti E.
A1  - Iskin, Ugur
A1  - Bezirci, Gizem
A1  - Tavsanoglu, Ulku Nihan
A1  - Celik, Kemal
A1  - Ozhan, Koray
A1  - Karakaya, Nusret
A1  - Kocer, Mehmet Ali Turan
A1  - Yilmaz, Mete
A1  - Maraslioglu, Faruk
A1  - Fakioglu, Ozden
A1  - Soylu, Elif Neyran
A1  - Yagci, Meral Apaydin
A1  - Cinar, Sakir
A1  - Capkin, Kadir
A1  - Yagci, Abdulkadir
A1  - Cesur, Mehmet
A1  - Bilgin, Fuat
A1  - Bulut, Cafer
A1  - Uysal, Rahmi
A1  - Koker, Latife
A1  - Akcaalan, Reyhan
A1  - Albay, Meric
A1  - Alp, Mehmet Tahir
A1  - Ozkan, Korhan
A1  - Sevindik, Tugba Ongun
A1  - Tunca, Hatice
A1  - Onem, Burcin
A1  - Richardson, Jessica
A1  - Edwards, Christine
A1  - Bergkemper, Victoria
A1  - Beirne, Eilish
A1  - Cromie, Hannah
A1  - Ibelings, Bastiaan W.
T1  - Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
JF  - Scientific Data
N2  - Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.
KW  - Climate-change ecology
KW  - Limnology
KW  - Water resources
Y1  - 2018
U6  - https://doi.org/10.1038/sdata.2018.226
SN  - 2052-4463
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  -