TY - GEN
A1 - Herold, Fabian
A1 - Labott, Berit K.
A1 - Grässler, Bernhard
A1 - Halfpaap, Nicole
A1 - Langhans, Corinna
A1 - Müller, Patrick
A1 - Ammar, Achraf
A1 - Dordevic, Milos
A1 - Hökelmann, Anita
A1 - Müller, Notger Germar
T1 - A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 775
KW - MCI
KW - hippocampal-prefrontal network
KW - handgrip strength
KW - exercise cognition
KW - aging
KW - brain health
Y1 - 2022
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-559251
SN - 1866-8364
SP - 1
EP - 14
PB - Universitätsverlag Potsdam
CY - Potsdam
ER -
TY - JOUR
A1 - Klaus, Benita
A1 - Müller, Patrick
A1 - van Wickeren, Nora
A1 - Dordevic, Milos
A1 - Schmicker, Marlen
A1 - Zdunczyk, Yael
A1 - Brigadski, Tanja
A1 - Lessmann, Volkmar
A1 - Vielhaber, Stefan
A1 - Schreiber, Stefanie
A1 - Müller, Notger Germar
T1 - Structural and functional brain alterations in patients with myasthenia gravis
JF - Brain communications
N2 - Myasthenia gravis is an autoimmune disease affecting neuromuscular transmission and causing skeletal muscle weakness. Additionally, systemic inflammation, cognitive deficits and autonomic dysfunction have been described.
However, little is known about myasthenia gravis-related reorganization of the brain. In this study, we thus investigated the structural and functional brain changes in myasthenia gravis patients.
Eleven myasthenia gravis patients (age: 70.64 +/- 9.27; 11 males) were compared to age-, sex- and education-matched healthy controls (age: 70.18 +/- 8.98; 11 males). Most of the patients (n = 10, 0.91%) received cholinesterase inhibitors.
Structural brain changes were determined by applying voxel-based morphometry using high-resolution T-1-weighted sequences. Functional brain changes were assessed with a neuropsychological test battery (including attention, memory and executive functions), a spatial orientation task and brain-derived neurotrophic factor blood levels.
Myasthenia gravis patients showed significant grey matter volume reductions in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. Furthermore, myasthenia gravis patients showed significantly lower performance in executive functions, working memory (Spatial Span, P = 0.034, d = 1.466), verbal episodic memory (P = 0.003, d = 1.468) and somatosensory-related spatial orientation (Triangle Completion Test, P = 0.003, d = 1.200).
Additionally, serum brain-derived neurotrophic factor levels were significantly higher in myasthenia gravis patients (P = 0.001, d = 2.040). Our results indicate that myasthenia gravis is associated with structural and functional brain alterations. Especially the grey matter volume changes in the cingulate gyrus and the inferior parietal lobe could be associated with cognitive deficits in memory and executive functions.
Furthermore, deficits in somatosensory-related spatial orientation could be associated with the lower volumes in the inferior parietal lobe. Future research is needed to replicate these findings independently in a larger sample and to investigate the underlying mechanisms in more detail.
Klaus et al. compared myasthenia gravis patients to matched healthy control subjects and identified functional alterations in memory functions as well as structural alterations in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus.
KW - myasthenia gravis
KW - neuroplasticity
KW - VBM
KW - neuropsychological testing
KW - BDNF
Y1 - 2022
U6 - https://doi.org/10.1093/braincomms/fcac018
SN - 2632-1297
VL - 4
IS - 1
PB - Oxford Univ. Press
CY - Oxford
ER -
TY - JOUR
A1 - Menze, Inga
A1 - Müller, Patrick
A1 - Müller, Notger Germar
A1 - Schmicker, Marlen
T1 - Age-related cognitive effects of the COVID-19 pandemic restrictions and associated mental health changes in Germans
JF - Scientific reports
N2 - Restrictive means to reduce the spread of the COVID-19 pandemic have not only imposed broad challenges on mental health but might also affect cognitive health. Here we asked how restriction-related changes influence cognitive performance and how age, perceived loneliness, depressiveness and affectedness by restrictions contribute to these effects. 51 Germans completed three assessments of an online based study during the first lockdown in Germany (April 2020), a month later, and during the beginning of the second lockdown (November 2020). Participants completed nine online cognitive tasks of the MyBrainTraining and online questionnaires about their perceived strain and impact on lifestyle factors by the situation (affectedness), perceived loneliness, depressiveness as well as subjective cognitive performance. The results suggested a possible negative impact of depressiveness and affectedness on objective cognitive performance within the course of the lockdown. The younger the participants, the more pronounced these effects were. Loneliness and depressiveness moreover contributed to a worse evaluation of subjective cognition. In addition, especially younger individuals reported increased distress. As important educational and social input has partly been scarce during this pandemic and mental health problems have increased, future research should also assess cognitive long-term consequences.
Y1 - 2022
U6 - https://doi.org/10.1038/s41598-022-11283-9
SN - 2045-2322
VL - 12
IS - 1
PB - Nature portfolio
CY - Berlin
ER -
TY - JOUR
A1 - Schmicker, Marlen
A1 - Frühling, Insa
A1 - Menze, Inga
A1 - Glanz, Wenzel
A1 - Müller, Patrick
A1 - Noesselt, Toemme
A1 - Müller, Notger Germar
T1 - The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline
JF - Journal of Alzheimer's disease reports : JADR
N2 - Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit.
Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD.
Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration.
Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients.
Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.
KW - Alzheimer's disease
KW - dementia
KW - diagnostic marker
KW - early diagnosis
KW - subjective cognitive decline
KW - taste
Y1 - 2023
U6 - https://doi.org/10.3233/ADR220092
SN - 2542-4823
VL - 7
IS - 1
SP - 249
EP - 262
PB - IOS Press
CY - Clifton, VA
ER -
TY - JOUR
A1 - Herold, Fabian
A1 - Labott, Berit K.
A1 - Grässler, Bernhard
A1 - Halfpaap, Nicole
A1 - Langhans, Corinna
A1 - Müller, Patrick
A1 - Ammar, Achraf
A1 - Dordevic, Milos
A1 - Hökelmann, Anita
A1 - Müller, Notger Germar
T1 - A Link between Handgrip Strength and Executive Functioning: A Cross-Sectional Study in Older Adults with Mild Cognitive Impairment and Healthy Controls
JF - Healthcare : open access journal
N2 - Older adults with amnestic mild cognitive impairment (aMCI) who in addition to their memory deficits also suffer from frontal-executive dysfunctions have a higher risk of developing dementia later in their lives than older adults with aMCI without executive deficits and older adults with non-amnestic MCI (naMCI). Handgrip strength (HGS) is also correlated with the risk of cognitive decline in the elderly. Hence, the current study aimed to investigate the associations between HGS and executive functioning in individuals with aMCI, naMCI and healthy controls. Older, right-handed adults with amnestic MCI (aMCI), non-amnestic MCI (naMCI), and healthy controls (HC) conducted a handgrip strength measurement via a handheld dynamometer. Executive functions were assessed with the Trail Making Test (TMT A&B). Normalized handgrip strength (nHGS, normalized to Body Mass Index (BMI)) was calculated and its associations with executive functions (operationalized through z-scores of TMT B/A ratio) were investigated through partial correlation analyses (i.e., accounting for age, sex, and severity of depressive symptoms). A positive and low-to-moderate correlation between right nHGS (rp (22) = 0.364; p = 0.063) and left nHGS (rp (22) = 0.420; p = 0.037) and executive functioning in older adults with aMCI but not in naMCI or HC was observed. Our results suggest that higher levels of nHGS are linked to better executive functioning in aMCI but not naMCI and HC. This relationship is perhaps driven by alterations in the integrity of the hippocampal-prefrontal network occurring in older adults with aMCI. Further research is needed to provide empirical evidence for this assumption.
KW - MCI
KW - hippocampal-prefrontal network
KW - handgrip strength
KW - exercise cognition
KW - aging
KW - brain health
Y1 - 2022
U6 - https://doi.org/10.3390/healthcare10020230
SN - 2227-9032
VL - 10
SP - 1
EP - 14
PB - MDPI
CY - Basel, Schweiz
ET - 2
ER -
TY - JOUR
A1 - Wiese, Heike
A1 - Mayr, Katharina
A1 - Krämer, Philipp
A1 - Seeger, Patrick
A1 - Müller, Hans-Georg
A1 - Mezger, Verena
T1 - Changing teachers' attitudes towards linguistic diversity
BT - effects of an anti-bias programme
JF - International Journal of Applied Linguistics
N2 - We discuss an intervention programme for kindergarten and school teachers' continuing education in Germany that targets biases against language outside a perceived monolingual ‘standard’ and its speakers. The programme combines anti-bias methods relating to linguistic diversity with objectives of raising critical language awareness. Evaluation through teachers' workshops in Berlin and Brandenburg points to positive and enduring attitudinal changes in participants, but not in control groups that did not attend workshops, and effects were independent of personal variables gender and teaching subject and only weakly associated with age. We relate these effects to such programme features as indirect and inclusive methods that foster active engagement, and the combination of ‘safer’ topics targeting attitudes towards linguistic structures with more challenging ones dealing with the discrimination of speakers.
N2 - Der Beitrag diskutiert ein Interventionsprogramm fur die Weiterbildung von Lehrer/inne/n und Erzieher/inne/n, das Vorurteile gegenuber sprachlichen Praktiken au ss erhalb eines vermeintlichen monolingualen Standarddeutschen und seinen Sprecher/inne/n fokussiert (). Das Programm verbindet Anti-bias -Methoden zur sprachlichen Vielfalt mit solchen, die auf eine Verstarkung kritischer Sprachbewusstheit abheben. Die Evaluation der Materialien in Lehrerfortbildungen in Berlin und Brandenburg weist auf positive und anhaltende Einstellungsveranderungen bei den Teilnehmer/inne/n, aber nicht bei Mitgliedern einer Kontrollgruppe, die nicht an den Fortbildungen teilnahm; die Effekte waren unabhangig von den personenbezogen Variablen Geschlecht und Lehrfach und nur schwach mit Alter assoziiert. Wir diskutieren diese Effekte im Zusammenhang mit Eigenschaften des Programms wie der Verwendung indirekter und inklusiver Methoden, die eine aktive Auseinandersetzung fordern, und der Verbindung von weniger bedrohlichen Themen, die sich auf Einstellungen gegenuber sprachlichen Strukturen beziehen, mit solchen, die die Diskrimierung von Sprecher/inne/n behandeln und daher eine gro ss ere Herausforderung darstellen
KW - anti-bias
KW - critical language awareness
KW - language and education in multilingual settings
KW - language attitudes
KW - linguistic discrimination
Y1 - 2017
U6 - https://doi.org/10.1111/ijal.12121
SN - 0802-6106
SN - 1473-4192
VL - 27
IS - 1
SP - 198
EP - 220
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Müller, Hans-Georg
A1 - Wiese, Heike
A1 - Mayr, Katharina
A1 - Krämer, Philipp
A1 - Seeger, Patrick
A1 - Mezger, Verena
T1 - Changing teachers' attitudes towards linguistic diversity
BT - effects of an anti‐bias programme
JF - International Journal of Applied Linguistics
N2 - We discuss an intervention programme for kindergarten and school teachers' continuing education in Germany that targets biases against language outside a perceived monolingual ‘standard’ and its speakers. The programme combines anti-bias methods relating to linguistic diversity with objectives of raising critical language awareness. Evaluation through teachers' workshops in Berlin and Brandenburg points to positive and enduring attitudinal changes in participants, but not in control groups that did not attend workshops, and effects were independent of personal variables gender and teaching subject and only weakly associated with age. We relate these effects to such programme features as indirect and inclusive methods that foster active engagement, and the combination of ‘safer’ topics targeting attitudes towards linguistic structures with more challenging ones dealing with the discrimination of speakers.
N2 - Der Beitrag diskutiert ein Interventionsprogramm für die Weiterbildung von Lehrer/inne/n und Erzieher/inne/n, das Vorurteile gegenüber sprachlichen Praktiken außerhalb eines vermeintlichen monolingualen „Standarddeutschen“ und seinen Sprecher/inne/n fokussiert (www.deutsch-ist-vielseitig.de). Das Programm verbindet Anti-bias -Methoden zur sprachlichen Vielfalt mit solchen, die auf eine Verstärkung kritischer Sprachbewusstheit abheben. Die Evaluation der Materialien in Lehrerfortbildungen in Berlin und Brandenburg weist auf positive und anhaltende Einstellungsveränderungen bei den Teilnehmer/inne/n, aber nicht bei Mitgliedern einer Kontrollgruppe, die nicht an den Fortbildungen teilnahm; die Effekte waren unabhängig von den personenbezogen Variablen Geschlecht und Lehrfach und nur schwach mit Alter assoziiert. Wir diskutieren diese Effekte im Zusammenhang mit Eigenschaften des Programms wie der Verwendung indirekter und inklusiver Methoden, die eine aktive Auseinandersetzung fördern, und der Verbindung von weniger „bedrohlichen“ Themen, die sich auf Einstellungen gegenüber sprachlichen Strukturen beziehen, mit solchen, die die Diskrimierung von Sprecher/inne/n behandeln und daher eine größere Herausforderung darstellen
KW - Mehrsprachigkeit
Y1 - 2015
VL - 27
IS - 1
SP - 198
EP - 220
ER -
TY - CHAP
A1 - Müller, Petra
A1 - Coppock, Patrick
A1 - Liebe, Michael
A1 - Mersch, Dieter
A1 - Bogost, Ian
A1 - Bartle, Richard
A1 - Juul, Jesper
A1 - Løvlie, Anders Sundnes
A1 - Pohl, Kirsten
A1 - Schrape, Niklas
A1 - Hoffstadt, Christian
A1 - Nagenborg, Michael
A1 - Liboriussen, Bjarke
A1 - Meldgaard, Betty Li
A1 - Günzel, Stephan
A1 - Ljungström, Mattias
A1 - Jennett, Charlene
A1 - Cox, Anna L.
A1 - Cairns, Paul
A1 - Mukherjee, Souvik
A1 - Pinchbeck, Dan
A1 - Glashüttner, Robert
ED - Günzel, Stephan
ED - Liebe, Michael
ED - Mersch, Dieter
T1 - Conference proceedings of The Philosophy of Computer Games 2008
N2 - This first volume of the DIGAREC Series holds the proceedings of the conference “The Philosophy of Computer Games”, held at the University of Potsdam from May 8-10, 2008. The contributions of the conference address three fields of computer game research that are philosophically relevant and, likewise, to which philosophical reflection is crucial. These are: ethics and politics, the action-space of games, and the magic circle. All three topics are interlinked and constitute the paradigmatic object of computer games: Whereas the first describes computer games on the outside, looking at the cultural effects of games as well as on moral practices acted out with them, the second describes computer games on the inside, i.e. how they are constituted as a medium. The latter finally discusses the way in which a border between these two realms, games and non-games, persists or is already transgressed in respect to a general performativity.
T3 - DIGAREC Series - 01
Y1 - 2008
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-20072
SN - 978-3-940793-49-2
PB - Universitätsverlag Potsdam
CY - Potsdam
ER -
TY - JOUR
A1 - Aarts, Alexander A.
A1 - Anderson, Joanna E.
A1 - Anderson, Christopher J.
A1 - Attridge, Peter R.
A1 - Attwood, Angela
A1 - Axt, Jordan
A1 - Babel, Molly
A1 - Bahnik, Stepan
A1 - Baranski, Erica
A1 - Barnett-Cowan, Michael
A1 - Bartmess, Elizabeth
A1 - Beer, Jennifer
A1 - Bell, Raoul
A1 - Bentley, Heather
A1 - Beyan, Leah
A1 - Binion, Grace
A1 - Borsboom, Denny
A1 - Bosch, Annick
A1 - Bosco, Frank A.
A1 - Bowman, Sara D.
A1 - Brandt, Mark J.
A1 - Braswell, Erin
A1 - Brohmer, Hilmar
A1 - Brown, Benjamin T.
A1 - Brown, Kristina
A1 - Bruening, Jovita
A1 - Calhoun-Sauls, Ann
A1 - Callahan, Shannon P.
A1 - Chagnon, Elizabeth
A1 - Chandler, Jesse
A1 - Chartier, Christopher R.
A1 - Cheung, Felix
A1 - Christopherson, Cody D.
A1 - Cillessen, Linda
A1 - Clay, Russ
A1 - Cleary, Hayley
A1 - Cloud, Mark D.
A1 - Cohn, Michael
A1 - Cohoon, Johanna
A1 - Columbus, Simon
A1 - Cordes, Andreas
A1 - Costantini, Giulio
A1 - Alvarez, Leslie D. Cramblet
A1 - Cremata, Ed
A1 - Crusius, Jan
A1 - DeCoster, Jamie
A1 - DeGaetano, Michelle A.
A1 - Della Penna, Nicolas
A1 - den Bezemer, Bobby
A1 - Deserno, Marie K.
A1 - Devitt, Olivia
A1 - Dewitte, Laura
A1 - Dobolyi, David G.
A1 - Dodson, Geneva T.
A1 - Donnellan, M. Brent
A1 - Donohue, Ryan
A1 - Dore, Rebecca A.
A1 - Dorrough, Angela
A1 - Dreber, Anna
A1 - Dugas, Michelle
A1 - Dunn, Elizabeth W.
A1 - Easey, Kayleigh
A1 - Eboigbe, Sylvia
A1 - Eggleston, Casey
A1 - Embley, Jo
A1 - Epskamp, Sacha
A1 - Errington, Timothy M.
A1 - Estel, Vivien
A1 - Farach, Frank J.
A1 - Feather, Jenelle
A1 - Fedor, Anna
A1 - Fernandez-Castilla, Belen
A1 - Fiedler, Susann
A1 - Field, James G.
A1 - Fitneva, Stanka A.
A1 - Flagan, Taru
A1 - Forest, Amanda L.
A1 - Forsell, Eskil
A1 - Foster, Joshua D.
A1 - Frank, Michael C.
A1 - Frazier, Rebecca S.
A1 - Fuchs, Heather
A1 - Gable, Philip
A1 - Galak, Jeff
A1 - Galliani, Elisa Maria
A1 - Gampa, Anup
A1 - Garcia, Sara
A1 - Gazarian, Douglas
A1 - Gilbert, Elizabeth
A1 - Giner-Sorolla, Roger
A1 - Glöckner, Andreas
A1 - Göllner, Lars
A1 - Goh, Jin X.
A1 - Goldberg, Rebecca
A1 - Goodbourn, Patrick T.
A1 - Gordon-McKeon, Shauna
A1 - Gorges, Bryan
A1 - Gorges, Jessie
A1 - Goss, Justin
A1 - Graham, Jesse
A1 - Grange, James A.
A1 - Gray, Jeremy
A1 - Hartgerink, Chris
A1 - Hartshorne, Joshua
A1 - Hasselman, Fred
A1 - Hayes, Timothy
A1 - Heikensten, Emma
A1 - Henninger, Felix
A1 - Hodsoll, John
A1 - Holubar, Taylor
A1 - Hoogendoorn, Gea
A1 - Humphries, Denise J.
A1 - Hung, Cathy O. -Y.
A1 - Immelman, Nathali
A1 - Irsik, Vanessa C.
A1 - Jahn, Georg
A1 - Jaekel, Frank
A1 - Jekel, Marc
A1 - Johannesson, Magnus
A1 - Johnson, Larissa G.
A1 - Johnson, David J.
A1 - Johnson, Kate M.
A1 - Johnston, William J.
A1 - Jonas, Kai
A1 - Joy-Gaba, Jennifer A.
A1 - Kappes, Heather Barry
A1 - Kelso, Kim
A1 - Kidwell, Mallory C.
A1 - Kim, Seung Kyung
A1 - Kirkhart, Matthew
A1 - Kleinberg, Bennett
A1 - Knezevic, Goran
A1 - Kolorz, Franziska Maria
A1 - Kossakowski, Jolanda J.
A1 - Krause, Robert Wilhelm
A1 - Krijnen, Job
A1 - Kuhlmann, Tim
A1 - Kunkels, Yoram K.
A1 - Kyc, Megan M.
A1 - Lai, Calvin K.
A1 - Laique, Aamir
A1 - Lakens, Daniel
A1 - Lane, Kristin A.
A1 - Lassetter, Bethany
A1 - Lazarevic, Ljiljana B.
A1 - LeBel, Etienne P.
A1 - Lee, Key Jung
A1 - Lee, Minha
A1 - Lemm, Kristi
A1 - Levitan, Carmel A.
A1 - Lewis, Melissa
A1 - Lin, Lin
A1 - Lin, Stephanie
A1 - Lippold, Matthias
A1 - Loureiro, Darren
A1 - Luteijn, Ilse
A1 - Mackinnon, Sean
A1 - Mainard, Heather N.
A1 - Marigold, Denise C.
A1 - Martin, Daniel P.
A1 - Martinez, Tylar
A1 - Masicampo, E. J.
A1 - Matacotta, Josh
A1 - Mathur, Maya
A1 - May, Michael
A1 - Mechin, Nicole
A1 - Mehta, Pranjal
A1 - Meixner, Johannes
A1 - Melinger, Alissa
A1 - Miller, Jeremy K.
A1 - Miller, Mallorie
A1 - Moore, Katherine
A1 - Möschl, Marcus
A1 - Motyl, Matt
A1 - Müller, Stephanie M.
A1 - Munafo, Marcus
A1 - Neijenhuijs, Koen I.
A1 - Nervi, Taylor
A1 - Nicolas, Gandalf
A1 - Nilsonne, Gustav
A1 - Nosek, Brian A.
A1 - Nuijten, Michele B.
A1 - Olsson, Catherine
A1 - Osborne, Colleen
A1 - Ostkamp, Lutz
A1 - Pavel, Misha
A1 - Penton-Voak, Ian S.
A1 - Perna, Olivia
A1 - Pernet, Cyril
A1 - Perugini, Marco
A1 - Pipitone, R. Nathan
A1 - Pitts, Michael
A1 - Plessow, Franziska
A1 - Prenoveau, Jason M.
A1 - Rahal, Rima-Maria
A1 - Ratliff, Kate A.
A1 - Reinhard, David
A1 - Renkewitz, Frank
A1 - Ricker, Ashley A.
A1 - Rigney, Anastasia
A1 - Rivers, Andrew M.
A1 - Roebke, Mark
A1 - Rutchick, Abraham M.
A1 - Ryan, Robert S.
A1 - Sahin, Onur
A1 - Saide, Anondah
A1 - Sandstrom, Gillian M.
A1 - Santos, David
A1 - Saxe, Rebecca
A1 - Schlegelmilch, Rene
A1 - Schmidt, Kathleen
A1 - Scholz, Sabine
A1 - Seibel, Larissa
A1 - Selterman, Dylan Faulkner
A1 - Shaki, Samuel
A1 - Simpson, William B.
A1 - Sinclair, H. Colleen
A1 - Skorinko, Jeanine L. M.
A1 - Slowik, Agnieszka
A1 - Snyder, Joel S.
A1 - Soderberg, Courtney
A1 - Sonnleitner, Carina
A1 - Spencer, Nick
A1 - Spies, Jeffrey R.
A1 - Steegen, Sara
A1 - Stieger, Stefan
A1 - Strohminger, Nina
A1 - Sullivan, Gavin B.
A1 - Talhelm, Thomas
A1 - Tapia, Megan
A1 - te Dorsthorst, Anniek
A1 - Thomae, Manuela
A1 - Thomas, Sarah L.
A1 - Tio, Pia
A1 - Traets, Frits
A1 - Tsang, Steve
A1 - Tuerlinckx, Francis
A1 - Turchan, Paul
A1 - Valasek, Milan
A1 - Van Aert, Robbie
A1 - van Assen, Marcel
A1 - van Bork, Riet
A1 - van de Ven, Mathijs
A1 - van den Bergh, Don
A1 - van der Hulst, Marije
A1 - van Dooren, Roel
A1 - van Doorn, Johnny
A1 - van Renswoude, Daan R.
A1 - van Rijn, Hedderik
A1 - Vanpaemel, Wolf
A1 - Echeverria, Alejandro Vasquez
A1 - Vazquez, Melissa
A1 - Velez, Natalia
A1 - Vermue, Marieke
A1 - Verschoor, Mark
A1 - Vianello, Michelangelo
A1 - Voracek, Martin
A1 - Vuu, Gina
A1 - Wagenmakers, Eric-Jan
A1 - Weerdmeester, Joanneke
A1 - Welsh, Ashlee
A1 - Westgate, Erin C.
A1 - Wissink, Joeri
A1 - Wood, Michael
A1 - Woods, Andy
A1 - Wright, Emily
A1 - Wu, Sining
A1 - Zeelenberg, Marcel
A1 - Zuni, Kellylynn
T1 - Estimating the reproducibility of psychological science
JF - Science
N2 - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1 - 2015
U6 - https://doi.org/10.1126/science.aac4716
SN - 1095-9203
SN - 0036-8075
VL - 349
IS - 6251
PB - American Assoc. for the Advancement of Science
CY - Washington
ER -
TY - JOUR
A1 - Grott, Matthias
A1 - Knollenberg, J.
A1 - Hamm, M.
A1 - Ogawa, K.
A1 - Jaumann, R.
A1 - Otto, Katharina Alexandra
A1 - Delbo, M.
A1 - Michel, Patrick
A1 - Biele, J.
A1 - Neumann, Wladimir
A1 - Knapmeyer, Martin
A1 - Kührt, E.
A1 - Senshu, H.
A1 - Okada, T.
A1 - Helbert, Jorn
A1 - Maturilli, A.
A1 - Müller, N.
A1 - Hagermann, A.
A1 - Sakatani, Naoya
A1 - Tanaka, S.
A1 - Arai, T.
A1 - Mottola, Stefano
A1 - Tachibana, Shogo
A1 - Pelivan, Ivanka
A1 - Drube, Line
A1 - Vincent, J-B
A1 - Yano, Hajime
A1 - Pilorget, C.
A1 - Matz, K. D.
A1 - Schmitz, N.
A1 - Koncz, A.
A1 - Schröder, Stefan E.
A1 - Trauthan, F.
A1 - Schlotterer, Markus
A1 - Krause, C.
A1 - Ho, T-M
A1 - Moussi-Soffys, A.
T1 - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF - Nature astronomy
N2 - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7
Y1 - 2019
U6 - https://doi.org/10.1038/s41550-019-0832-x
SN - 2397-3366
VL - 3
IS - 11
SP - 971
EP - 976
PB - Nature Publishing Group
CY - London
ER -
TY - JOUR
A1 - Klingstrom, Tomas
A1 - Soldatova, Larissa
A1 - Stevens, Robert
A1 - Roos, T. Erik
A1 - Swertz, Morris A.
A1 - Müller, Kristian M.
A1 - Kalas, Matus
A1 - Lambrix, Patrick
A1 - Taussig, Michael J.
A1 - Litton, Jan-Eric
A1 - Landegren, Ulf
A1 - Bongcam-Rudloff, Erik
T1 - Workshop on laboratory protocol standards for the molecular methods database
JF - New biotechnology
N2 - Management of data to produce scientific knowledge is a key challenge for biological research in the 21st century. Emerging high-throughput technologies allow life science researchers to produce big data at speeds and in amounts that were unthinkable just a few years ago. This places high demands on all aspects of the workflow: from data capture (including the experimental constraints of the experiment), analysis and preservation, to peer-reviewed publication of results. Failure to recognise the issues at each level can lead to serious conflicts and mistakes; research may then be compromised as a result of the publication of non-coherent protocols, or the misinterpretation of published data. In this report, we present the results from a workshop that was organised to create an ontological data-modelling framework for Laboratory Protocol Standards for the Molecular Methods Database (MolMeth). The workshop provided a set of short- and long-term goals for the MolMeth database, the most important being the decision to use the established EXACT description of biomedical ontologies as a starting point.
Y1 - 2013
U6 - https://doi.org/10.1016/j.nbt.2012.05.019
SN - 1871-6784
VL - 30
IS - 2
SP - 109
EP - 113
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Rössler, Patrick
A1 - Bomhoff, Jana
A1 - Haschke, Josef Ferdinand
A1 - Kersten, Jan
A1 - Müller, Rüdiger
T1 - Selection and impact of press photography
BT - an empirical study on the basis of photo news factors
JF - Communications : the European journal of communication research
N2 - The selection of 'good' pictures has increasingly become a crucial factor when transmitting news to the recipients. Every day thousands of events are happening and millions of pictures are taken. By choosing photographs for newspapers and magazines, photographic editorial departments want to attract the recipients' attention, evoke emotions and get them to read their stories. But what exactly is a good picture that meets these expectations? Which criteria are decisive for selecting pictures and what effects of this selection can be measured on the recipients' side?
This article presents the results of a research project carried out at the University of Erfurt in 2008 and conducted in collaboration with the German weekly magazine stern. It deals with the selection and impact of press photography by introducing the concept 'photo news factors'. Applying the traditional news value theory to pictures, photo news factors are defined as selection criteria that, on the part of the communicator, decide whether the press photos are worth publishing. Furthermore, they are assumed to exert an influence on the intensity of attention that a picture arouses.
KW - press photography
KW - news value theory
KW - photo news factors selectivity
KW - media effects
Y1 - 2011
U6 - https://doi.org/10.1515/COMM.2011.021
SN - 0341-2059
VL - 36
IS - 4
SP - 415
EP - 439
PB - De Gruyter Mouton
CY - Berlin
ER -
TY - JOUR
A1 - Czarnocka, Weronika
A1 - Van Der Kelen, Katrien
A1 - Willems, Patrick
A1 - Szechynska-Hebda, Magdalena
A1 - Shahnejat-Bushehri, Sara
A1 - Balazadeh, Salma
A1 - Rusaczonek, Anna
A1 - Müller-Röber, Bernd
A1 - Van Breusegem, Frank
A1 - Karpinski, Stanislaw
T1 - The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator
JF - Plant, cell & environment : cell physiology, whole-plant physiology, community physiology
N2 - Since its discovery over two decades ago as an important cell death regulator in Arabidopsis thaliana, the role of LESION SIMULATING DISEASE 1 (LSD1) has been studied intensively within both biotic and abiotic stress responses as well as with respect to plant fitness regulation. However, its molecular mode of action remains enigmatic. Here, we demonstrate that nucleo-cytoplasmic LSD1 interacts with a broad range of other proteins that are engaged in various molecular pathways such as ubiquitination, methylation, cell cycle control, gametogenesis, embryo development and cell wall formation. The interaction of LSD1 with these partners is dependent on redox status, as oxidative stress significantly changes the quantity and types of LSD1-formed complexes. Furthermore, we show that LSD1 regulates the number and size of leaf mesophyll cells and affects plant vegetative growth. Importantly, we also reveal that in addition to its function as a scaffold protein, LSD1 acts as a transcriptional regulator. Taken together, our results demonstrate that LSD1 plays a dual role within the cell by acting as a condition-dependent scaffold protein and as a transcription regulator.
KW - Arabidopsis
KW - thaliana
KW - dry weight
KW - LSD1
KW - oxidative stress
KW - protein interaction
KW - transcription regulation
Y1 - 2017
U6 - https://doi.org/10.1111/pce.12994
SN - 0140-7791
SN - 1365-3040
VL - 40
SP - 2644
EP - 2662
PB - Wiley
CY - Hoboken
ER -
TY - JOUR
A1 - Bailis, Peter
A1 - Dillahunt, Tawanna
A1 - Müller, Stefanie
A1 - Baudisch, Patrick
T1 - Research for Practice: Technology for Underserved Communities; Personal Fabrication
JF - Communications of the ACM / Association for Computing Machinery
N2 - THIS INSTALLMENT OF Research for Practice provides curated reading guides to technology for underserved communities and to new developments in personal fabrication. First, Tawanna Dillahunt describes design considerations and technology for underserved and impoverished communities. Designing for the more than 1.6 billion impoverished individuals worldwide requires special consideration of community needs, constraints, and context. Her selections span protocols for poor-quality communication networks, community-driven content generation, and resource and public service discovery. Second, Stefanie Mueller and Patrick Baudisch provide an overview of recent advances in personal fabrication (for example, 3D printers).
Y1 - 2017
U6 - https://doi.org/10.1145/3080188
SN - 0001-0782
SN - 1557-7317
VL - 60
SP - 46
EP - 49
PB - Association for Computing Machinery
CY - New York
ER -
TY - JOUR
A1 - Garapati, Prashanth
A1 - Feil, Regina
A1 - Lunn, John Edward
A1 - Van Dijck, Patrick
A1 - Balazadeh, Salma
A1 - Müller-Röber, Bernd
T1 - Transcription Factor Arabidopsis Activating Factor1 Integrates Carbon Starvation Responses with Trehalose Metabolism
JF - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants
N2 - Plants respond to low carbon supply by massive reprogramming of the transcriptome and metabolome. We show here that the carbon starvation-induced NAC (for NO APICAL MERISTEM/ARABIDOPSIS TRANSCRIPTION ACTIVATION FACTOR/CUP-SHAPED COTYLEDON) transcription factor Arabidopsis (Arabidopsis thaliana) Transcription Activation Factor1 (ATAF1) plays an important role in this physiological process. We identified TREHALASE1, the only trehalase-encoding gene in Arabidopsis, as a direct downstream target of ATAF1. Overexpression of ATAF1 activates TREHALASE1 expression and leads to reduced trehalose-6-phosphate levels and a sugar starvation metabolome. In accordance with changes in expression of starch biosynthesis-and breakdown-related genes, starch levels are generally reduced in ATAF1 overexpressors but elevated in ataf1 knockout plants. At the global transcriptome level, genes affected by ATAF1 are broadly associated with energy and carbon starvation responses. Furthermore, transcriptional responses triggered by ATAF1 largely overlap with expression patterns observed in plants starved for carbon or energy supply. Collectively, our data highlight the existence of a positively acting feedforward loop between ATAF1 expression, which is induced by carbon starvation, and the depletion of cellular carbon/energy pools that is triggered by the transcriptional regulation of downstream gene regulatory networks by ATAF1.
Y1 - 2015
U6 - https://doi.org/10.1104/pp.15.00917
SN - 0032-0889
SN - 1532-2548
VL - 169
IS - 1
SP - 379
EP - 390
PB - American Society of Plant Physiologists
CY - Rockville
ER -
TY - CHAP
A1 - Kurbel, Karl
A1 - Nowak, Dawid
A1 - Azodi, Amir
A1 - Jaeger, David
A1 - Meinel, Christoph
A1 - Cheng, Feng
A1 - Sapegin, Andrey
A1 - Gawron, Marian
A1 - Morelli, Frank
A1 - Stahl, Lukas
A1 - Kerl, Stefan
A1 - Janz, Mariska
A1 - Hadaya, Abdulmasih
A1 - Ivanov, Ivaylo
A1 - Wiese, Lena
A1 - Neves, Mariana
A1 - Schapranow, Matthieu-Patrick
A1 - Fähnrich, Cindy
A1 - Feinbube, Frank
A1 - Eberhardt, Felix
A1 - Hagen, Wieland
A1 - Plauth, Max
A1 - Herscheid, Lena
A1 - Polze, Andreas
A1 - Barkowsky, Matthias
A1 - Dinger, Henriette
A1 - Faber, Lukas
A1 - Montenegro, Felix
A1 - Czachórski, Tadeusz
A1 - Nycz, Monika
A1 - Nycz, Tomasz
A1 - Baader, Galina
A1 - Besner, Veronika
A1 - Hecht, Sonja
A1 - Schermann, Michael
A1 - Krcmar, Helmut
A1 - Wiradarma, Timur Pratama
A1 - Hentschel, Christian
A1 - Sack, Harald
A1 - Abramowicz, Witold
A1 - Sokolowska, Wioletta
A1 - Hossa, Tymoteusz
A1 - Opalka, Jakub
A1 - Fabisz, Karol
A1 - Kubaczyk, Mateusz
A1 - Cmil, Milena
A1 - Meng, Tianhui
A1 - Dadashnia, Sharam
A1 - Niesen, Tim
A1 - Fettke, Peter
A1 - Loos, Peter
A1 - Perscheid, Cindy
A1 - Schwarz, Christian
A1 - Schmidt, Christopher
A1 - Scholz, Matthias
A1 - Bock, Nikolai
A1 - Piller, Gunther
A1 - Böhm, Klaus
A1 - Norkus, Oliver
A1 - Clark, Brian
A1 - Friedrich, Björn
A1 - Izadpanah, Babak
A1 - Merkel, Florian
A1 - Schweer, Ilias
A1 - Zimak, Alexander
A1 - Sauer, Jürgen
A1 - Fabian, Benjamin
A1 - Tilch, Georg
A1 - Müller, David
A1 - Plöger, Sabrina
A1 - Friedrich, Christoph M.
A1 - Engels, Christoph
A1 - Amirkhanyan, Aragats
A1 - van der Walt, Estée
A1 - Eloff, J. H. P.
A1 - Scheuermann, Bernd
A1 - Weinknecht, Elisa
ED - Meinel, Christoph
ED - Polze, Andreas
ED - Oswald, Gerhard
ED - Strotmann, Rolf
ED - Seibold, Ulrich
ED - Schulzki, Bernhard
T1 - HPI Future SOC Lab
BT - Proceedings 2015
N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien.
In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor.
KW - Future SOC Lab
KW - Forschungsprojekte
KW - Multicore Architekturen
KW - In-Memory Technologie
KW - Cloud Computing
KW - maschinelles Lernen
KW - künstliche Intelligenz
Y1 - 2017
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516
ER -
TY - GEN
A1 - Rössler, Patrick
A1 - Bomhoff, Jana
A1 - Haschke, Josef Ferdinand
A1 - Kersten, Jan
A1 - Müller, Rüdiger
T1 - Selection and impact of press photography
BT - an empirical study on the basis of photo news factors
T2 - Postprints der Universität Potsdam : Philosophische Reihe
N2 - The selection of ‘good’ pictures has increasingly become a crucial factor when transmitting news to the recipients. Every day thousands of events are happening and millions of pictures are taken. By choosing photographs for newspapers and magazines, photographic editorial departments want to attract the recipients’ attention, evoke emotions and get them to read their stories. But what exactly is a good picture that meets these expectations? Which criteria are decisive for selecting pictures and what effects of this selection can be measured on the recipients’ side? This article presents the results of a research project carried out at the University of Erfurt in 2008 and conducted in collaboration with the German weekly magazine stern. It deals with the selection and impact of press photography by introducing the concept ‘photo news factors’. Applying the traditional news value theory to pictures, photo news factors are defined as selection criteria that, on the part of the communicator, decide whether the press photos are worth publishing. Furthermore, they are assumed to exert an influence on the intensity of attention that a picture arouses.
T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 103
KW - press photography
KW - news value theory
KW - photo news factors
KW - selectivity
KW - media effects
Y1 - 2016
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-93694
SN - 1866-8380
IS - 103
ER -
TY - BOOK
A1 - Denz, Rebekka
A1 - Rudolf, Gabi
A1 - Singer-Brehm, Elisabeth
A1 - Koch, Patrick B.
A1 - Weinhold, Beate
A1 - Wiesner, Linda
A1 - Eckl, Rebecca
A1 - Blum, Rahel
A1 - Müller, Monika
ED - Denz, Rebekka
ED - Rudolf, Gabi
T1 - Genisa-Blätter II
N2 - In den acht Beiträgen der „Genisa-Blätter II“ werden Funde aus verschiedenen fränkischen Genisot vorgestellt. Sie wurden im Rahmen eines interdisziplinären Workshops im Genisaprojekt Veitshöchheim von Nachwuchswissenschaftlerinnen und -wissenschaftlern aus ganz Deutschland bearbeitet. Die edierten Quellen sowie deren Einordnung durch die Autorinnen und Autoren geben vielfältige Einblicke in die Komplexität des historischen Judentums in Franken. Der Schwerpunkt dieser Ausgabe liegt auf Text- und Textilfunden aus dem Bereich der Religion.
KW - Genisa
KW - Jüdische Studien
KW - Geniza
KW - Jewish Studies
Y1 - 2017
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102539
SN - 978-3-86956-393-0
PB - Universitätsverlag Potsdam
CY - Potsdam
ER -
TY - JOUR
A1 - Abdalla, H.
A1 - Adam, R.
A1 - Aharonian, Felix A.
A1 - Benkhali, F. Ait
A1 - Angüner, Ekrem Oǧuzhan
A1 - Arcaro, C.
A1 - Armand, C.
A1 - Armstrong, T.
A1 - Ashkar, H.
A1 - Backes, M.
A1 - Baghmanyan, V.
A1 - Martins, V. Barbosa
A1 - Barnacka, A.
A1 - Barnard, M.
A1 - Becherini, Y.
A1 - Berge, D.
A1 - Bernlohr, K.
A1 - Bi, B.
A1 - Bottcher, M.
A1 - Boisson, C.
A1 - Bolmont, J.
A1 - de Lavergne, M. de Bony
A1 - Bordas, Pol
A1 - Breuhaus, M.
A1 - Brun, F.
A1 - Brun, P.
A1 - Bryan, M.
A1 - Buchele, M.
A1 - Bulik, T.
A1 - Bylund, T.
A1 - Caroff, S.
A1 - Carosi, A.
A1 - Casanova, Sabrina
A1 - Chand, T.
A1 - Chandra, S.
A1 - Chen, A.
A1 - Cotter, G.
A1 - Curylo, M.
A1 - Mbarubucyeye, J. Damascene
A1 - Davids, I. D.
A1 - Davies, J.
A1 - Deil, C.
A1 - Devin, J.
A1 - deWilt, P.
A1 - Dirson, L.
A1 - Djannati-Atai, A.
A1 - Dmytriiev, A.
A1 - Donath, A.
A1 - Doroshenko, V.
A1 - Duffy, C.
A1 - Dyks, J.
A1 - Egberts, Kathrin
A1 - Eichhorn, F.
A1 - Einecke, S.
A1 - Emery, G.
A1 - Ernenwein, J. -P.
A1 - Feijen, K.
A1 - Fegan, S.
A1 - Fiasson, A.
A1 - de Clairfontaine, G. Fichet
A1 - Fontaine, G.
A1 - Funk, S.
A1 - Fussling, Matthias
A1 - Gabici, S.
A1 - Gallant, Y. A.
A1 - Giavitto, G.
A1 - Giunti, L.
A1 - Glawion, D.
A1 - Glicenstein, J. F.
A1 - Gottschall, D.
A1 - Grondin, M. -H.
A1 - Hahn, J.
A1 - Haupt, M.
A1 - Hermann, G.
A1 - Hinton, J. A.
A1 - Hofmann, W.
A1 - Hoischen, Clemens
A1 - Holch, T. L.
A1 - Holler, M.
A1 - Horbe, M.
A1 - Horns, D.
A1 - Huber, D.
A1 - Jamrozy, M.
A1 - Jankowsky, D.
A1 - Jankowsky, F.
A1 - Jardin-Blicq, A.
A1 - Joshi, V.
A1 - Jung-Richardt, I.
A1 - Kasai, E.
A1 - Kastendieck, M. A.
A1 - Katarzynski, K.
A1 - Katz, U.
A1 - Khangulyan, D.
A1 - Khelifi, B.
A1 - Klepser, S.
A1 - Kluzniak, W.
A1 - Komin, Nu.
A1 - Konno, R.
A1 - Kosack, K.
A1 - Kostunin, D.
A1 - Kreter, M.
A1 - Lamanna, G.
A1 - Lemiere, A.
A1 - Lemoine-Goumard, M.
A1 - Lenain, J. -P.
A1 - Levy, C.
A1 - Lohse, T.
A1 - Lypova, I.
A1 - Mackey, J.
A1 - Majumdar, J.
A1 - Malyshev, D.
A1 - Malyshev, D.
A1 - Marandon, V.
A1 - Marchegiani, P.
A1 - Marcowith, Alexandre
A1 - Mares, A.
A1 - Marti-Devesa, G.
A1 - Marx, R.
A1 - Maurin, G.
A1 - Meintjes, P. J.
A1 - Meyer, M.
A1 - Mitchell, A.
A1 - Moderski, R.
A1 - Mohamed, M.
A1 - Mohrmann, L.
A1 - Montanari, A.
A1 - Moore, C.
A1 - Morris, P.
A1 - Moulin, Emmanuel
A1 - Muller, J.
A1 - Murach, T.
A1 - Nakashima, K.
A1 - Nayerhoda, A.
A1 - de Naurois, M.
A1 - Ndiyavala, H.
A1 - Niederwanger, F.
A1 - Niemiec, J.
A1 - Oakes, L.
A1 - O'Brien, Patrick
A1 - Odaka, H.
A1 - Ohm, S.
A1 - Olivera-Nieto, L.
A1 - Wilhelmi, E. de Ona
A1 - Ostrowski, M.
A1 - Oya, I.
A1 - Panter, M.
A1 - Panny, S.
A1 - Parsons, R. D.
A1 - Peron, G.
A1 - Peyaud, B.
A1 - Piel, Q.
A1 - Pita, S.
A1 - Poireau, V.
A1 - Noel, A. Priyana
A1 - Prokhorov, D. A.
A1 - Prokoph, H.
A1 - Puhlhofer, G.
A1 - Punch, M.
A1 - Quirrenbach, A.
A1 - Raab, S.
A1 - Rauth, R.
A1 - Reichherzer, P.
A1 - Reimer, A.
A1 - Reimer, O.
A1 - Remy, Q.
A1 - Renaud, M.
A1 - Rieger, F.
A1 - Rinchiuso, L.
A1 - Romoli, C.
A1 - Rowell, G.
A1 - Rudak, B.
A1 - Ruiz-Velasco, E.
A1 - Sahakian, V.
A1 - Sailer, S.
A1 - Sanchez, D. A.
A1 - Santangelo, Andrea
A1 - Sasaki, M.
A1 - Scalici, M.
A1 - Schussler, F.
A1 - Schutte, H. M.
A1 - Schwanke, U.
A1 - Schwemmer, S.
A1 - Seglar-Arroyo, M.
A1 - Senniappan, M.
A1 - Seyffert, A. S.
A1 - Shafi, N.
A1 - Shiningayamwe, K.
A1 - Simoni, R.
A1 - Sinha, A.
A1 - Sol, H.
A1 - Specovius, A.
A1 - Spencer, S.
A1 - Spir-Jacob, M.
A1 - Stawarz, L.
A1 - Sun, L.
A1 - Steenkamp, R.
A1 - Stegmann, C.
A1 - Steinmassl, S.
A1 - Steppa, C.
A1 - Takahashi, T.
A1 - Tavernier, T.
A1 - Taylor, A. M.
A1 - Terrier, R.
A1 - Tiziani, D.
A1 - Tluczykont, M.
A1 - Tomankova, L.
A1 - Trichard, C.
A1 - Tsirou, M.
A1 - Tuffs, R.
A1 - Uchiyama, Y.
A1 - van der Walt, D. J.
A1 - van Eldik, C.
A1 - van Rensburg, C.
A1 - van Soelen, B.
A1 - Vasileiadis, G.
A1 - Veh, J.
A1 - Venter, C.
A1 - Vincent, P.
A1 - Vink, J.
A1 - Volk, H. J.
A1 - Vuillaume, T.
A1 - Wadiasingh, Z.
A1 - Wagner, S. J.
A1 - Watson, J.
A1 - Werner, F.
A1 - White, R.
A1 - Wierzcholska, A.
A1 - Wong, Yu Wun
A1 - Yusafzai, A.
A1 - Zacharias, M.
A1 - Zanin, R.
A1 - Zargaryan, D.
A1 - Zdziarski, A. A.
A1 - Zech, Alraune
A1 - Zhu, S. J.
A1 - Ziegler, A.
A1 - Zorn, J.
A1 - Zouari, S.
A1 - Zywucka, N.
T1 - An extreme particle accelerator in the Galactic plane
BT - HESS J1826-130
JF - Astronomy and astrophysics : an international weekly journal
N2 - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW - ISM: supernova remnants
KW - ISM: clouds
KW - gamma rays: general
KW - gamma rays:
KW - ISM
Y1 - 2020
U6 - https://doi.org/10.1051/0004-6361/202038851
SN - 0004-6361
SN - 1432-0746
VL - 644
PB - EDP Sciences
CY - Les Ulis
ER -
TY - JOUR
A1 - Alseekh, Saleh
A1 - Tohge, Takayuki
A1 - Wendenberg, Regina
A1 - Scossa, Federico
A1 - Omranian, Nooshin
A1 - Li, Jie
A1 - Kleessen, Sabrina
A1 - Giavalisco, Patrick
A1 - Pleban, Tzili
A1 - Müller-Röber, Bernd
A1 - Zamir, Dani
A1 - Nikoloski, Zoran
A1 - Fernie, Alisdair
T1 - Identification and Mode of Inheritance of Quantitative Trait Loci for Secondary Metabolite Abundance in Tomato
JF - The plant cell
N2 - A large-scale metabolic quantitative trait loci (mQTL) analysis was performed on the well-characterized Solanum pennellii introgression lines to investigate the genomic regions associated with secondary metabolism in tomato fruit pericarp. In total, 679 mQTLs were detected across the 76 introgression lines. Heritability analyses revealed that mQTLs of secondary metabolism were less affected by environment than mQTLs of primary metabolism. Network analysis allowed us to assess the interconnectivity of primary and secondary metabolism as well as to compare and contrast their respective associations with morphological traits. Additionally, we applied a recently established real-time quantitative PCR platform to gain insight into transcriptional control mechanisms of a subset of the mQTLs, including those for hydroxycinnamates, acyl-sugar, naringenin chalcone, and a range of glycoalkaloids. Intriguingly, many of these compounds displayed a dominant-negative mode of inheritance, which is contrary to the conventional wisdom that secondary metabolite contents decreased on domestication. We additionally performed an exemplary evaluation of two candidate genes for glycolalkaloid mQTLs via the use of virus-induced gene silencing. The combined data of this study were compared with previous results on primary metabolism obtained from the same material and to other studies of natural variance of secondary metabolism.
Y1 - 2015
U6 - https://doi.org/10.1105/tpc.114.132266
SN - 1040-4651
SN - 1532-298X
VL - 27
IS - 3
SP - 485
EP - 512
PB - American Society of Plant Physiologists
CY - Rockville
ER -
TY - JOUR
A1 - Watanabe, Mutsumi
A1 - Balazadeh, Salma
A1 - Tohge, Takayuki
A1 - Erban, Alexander
A1 - Giavalisco, Patrick
A1 - Kopka, Joachim
A1 - Müller-Röber, Bernd
A1 - Fernie, Alisdair
A1 - Höfgen, Rainer
T1 - Comprehensive dissection of spatiotemporal metabolic shifts in primary, secondary, and lipid metabolism during developmental senescence in arabidopsis
JF - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants
N2 - Developmental senescence is a coordinated physiological process in plants and is critical for nutrient redistribution from senescing leaves to newly formed sink organs, including young leaves and developing seeds. Progress has been made concerning the genes involved and the regulatory networks controlling senescence. The resulting complex metabolome changes during senescence have not been investigated in detail yet. Therefore, we conducted a comprehensive profiling of metabolites, including pigments, lipids, sugars, amino acids, organic acids, nutrient ions, and secondary metabolites, and determined approximately 260 metabolites at distinct stages in leaves and siliques during senescence in Arabidopsis (Arabidopsis thaliana). This provided an extensive catalog of metabolites and their spatiotemporal cobehavior with progressing senescence. Comparison with silique data provides clues to source-sink relations. Furthermore, we analyzed the metabolite distribution within single leaves along the basipetal sink-source transition trajectory during senescence. Ceramides, lysolipids, aromatic amino acids, branched chain amino acids, and stress-induced amino acids accumulated, and an imbalance of asparagine/aspartate, glutamate/glutamine, and nutrient ions in the tip region of leaves was detected. Furthermore, the spatiotemporal distribution of tricarboxylic acid cycle intermediates was already changed in the presenescent leaves, and glucosinolates, raffinose, and galactinol accumulated in the base region of leaves with preceding senescence. These results are discussed in the context of current models of the metabolic shifts occurring during developmental and environmentally induced senescence. As senescence processes are correlated to crop yield, the metabolome data and the approach provided here can serve as a blueprint for the analysis of traits and conditions linking crop yield and senescence.
Y1 - 2013
U6 - https://doi.org/10.1104/pp.113.217380
SN - 0032-0889
VL - 162
IS - 3
SP - 1290
EP - 1310
PB - American Society of Plant Physiologists
CY - Rockville
ER -