TY - JOUR
A1 - Aichberger, Marion Christina
A1 - Montesinos, Amanda Heredia
A1 - Bromand, Zohra
A1 - Yesil, Rahsan
A1 - Temur-Erman, Selver
A1 - Rapp, Michael Armin
A1 - Heinz, Andreas
A1 - Schouler-Ocak, Meryam
T1 - Suicide attempt rates and intervention effects in women of Turkish origin in Berlin
JF - European psychiatry : the journal of the Association of European Psychiatrists
N2 - Purpose: Ethnic minority groups show elevated suicide attempt rates across Europe. Evidence suggests a similar trend for women of Turkish origin in Germany, yet data on suicidal behaviour in minorities in Germany is scarce. The objective was to examine rates of suicidal behaviour, underlying motives, and to explore the effectiveness of an intervention program.
Methods: From 05/2009-09/2011, data on all suicide attempts among women of Turkish origin who presented at a hospital-based emergency unit in Berlin, Germany, were collected. A multi-modal intervention was conducted in 2010 and the effects of age, generation and the intervention on suicide attempt rates were examined.
Results: At the start, the highest rate was found in women aged 18-24 years with 225.4 (95% CI = 208.8-242.0)/100,000. Adjustment disorder was the most prevalent diagnosis with 49.7% (n = 79), being more common in second-generation women (P = .004). Further analyses suggested an effect of the intervention in the youngest age group (trend change of beta = -1.25; P = .017).
Conclusion: Our findings suggest a particularly high rate of suicide attempts by 18-24-year-old, second-generation women of Turkish origin in Berlin. Furthermore, our results suggest a trend change in suicide attempts in women aged 18-24 years related to a population-based intervention program. (C) 2015 Elsevier Masson SAS. All rights reserved.
KW - Suicide attempt
KW - Incidence rates
KW - Turkish migrants
KW - Intervention study
Y1 - 2015
U6 - https://doi.org/10.1016/j.eurpsy.2014.12.003
SN - 0924-9338
SN - 1778-3585
VL - 30
IS - 4
SP - 480
EP - 485
PB - Elsevier
CY - Paris
ER -
TY - GEN
A1 - Awasthi, Swapnil
A1 - Kaminski, Jakob
A1 - Rapp, Michael Armin
A1 - Schlagenhauf, Florian
A1 - Walter, Henrik
A1 - Ruggeri, Barbara
A1 - Ripke, Stephan
A1 - Schumann, Gunter
A1 - Heinz, Andreas
T1 - A neural signature of malleability
BT - general intelligence correlates with ventral striatal activation and epigenetic makers of dopamine neurotransmission
T2 - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
N2 - General intelligence has a substantial genetic background in children, adolescents, and adults, but environmental factors also strongly correlate with cognitive performance as evidenced by a strong (up to one SD) increase in average intelligence test results in the second half of the previous century. This change occurred in a period apparently too short to accommodate radical genetic changes. It is highly suggestive that environmental factors interact with genotype by possible modification of epigenetic factors that regulate gene expression and thus contribute to individual malleability. This modification might as well be reflected in recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events.
Y1 - 2019
U6 - https://doi.org/10.1016/j.euroneuro.2017.08.139
SN - 0924-977X
SN - 1873-7862
VL - 29
SP - S858
EP - S859
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Bakanidze, George
A1 - Brandl, Eva J.
A1 - Hutzler, Christine
A1 - Aurass, Friederike
A1 - Onken, Silke
A1 - Rapp, Michael Armin
A1 - Puls, Imke
T1 - Association of Dystrobrevin-Binding Protein 1 Polymorphisms with Sustained Attention and Set-Shifting in Schizophrenia Patients
JF - Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography
N2 - Background: Despite extensive research in the past decades, the influence of genetics on cognitive functions in schizophrenia remains unclear. Dystrobrevin-binding protein 1 (DTNBP1) is one of the most promising candidate genes in schizophrenia. An association of DTNBP1 with cognitive dysfunction, particularly memory impairment, has been reported in a number of studies. However, the results remain inconsistent. The aim of this study was to measure the association between DTNBP1 polymorphisms and cognitive domains in a well-characterized sample. Methods: Ninety-one clinically stable schizophrenia outpatients underwent a battery of cognitive tests. Six single nucleotide polymorphisms (SNPs) of DTNBP1 were genotyped in all participants. Statistical and multivariate analyses were performed. Results: Factor analysis revealed 4 factors corresponding to distinct cognitive domains, namely sustained attention, set-shifting, executive functioning, and memory. We found a significant association of the rs909706 polymorphism with attention (p = 0.030) and a nonsignificant trend for set-shifting (p = 0.060). The other SNPs and haplotypes were not associated with cognitive function. Discussion: Replication of this finding in a larger sample is needed in order to confirm the importance of this particular polymorphism in the genetics of schizophrenia, particularly the distinct cognitive domains. In conclusion, the present study supports the involvement of DTNBP1 in the regulation of cognitive processes and demonstrates association in particular with sustained attention and set-shifting in schizophrenia patients. (C) 2016 S. Karger AG, Basel
KW - DTNBP1
KW - Genetics
KW - Cognitive dysfunction
KW - Factor analysis
Y1 - 2016
U6 - https://doi.org/10.1159/000450550
SN - 0302-282X
SN - 1423-0224
VL - 74
SP - 41
EP - 47
PB - Karger
CY - Basel
ER -
TY - JOUR
A1 - Balta Beylergil, Sinem
A1 - Beck, Anne
A1 - Deserno, Lorenz
A1 - Lorenz, Robert C.
A1 - Rapp, Michael Armin
A1 - Schlagenhauf, Florian
A1 - Heinz, Andreas
A1 - Obermayer, Klaus
T1 - Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence
JF - NeuroImage: Clinical : a journal of diseases affecting the nervous system
N2 - Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the “double-update” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.
KW - Alcohol dependence
KW - Prediction error
KW - Reinforcement learning
KW - Reversal learning
KW - Dorsolateral prefrontal cortex
KW - Decision-making
Y1 - 2017
U6 - https://doi.org/10.1016/j.nicl.2017.04.010
SN - 2213-1582
VL - 15
SP - 80
EP - 94
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Bangeow, Petjo
A1 - Rapp, Michael Armin
T1 - Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie
T1 - Assessment and use of 2016 reformed psychotherapeutic guideline
BT - Teil II : Ost-West- und Stadt-Land-Vergleich
BT - part II : comparing Eastern and Western Germany as well as urban and rural areas
JF - Psychiatrische Praxis : Sozialpsychiatrie, klinische Psychiatrie, public mental health, Versorgungsforschung
N2 - Ziel der Studie Dieser Artikel untersucht, inwiefern sich die 2016 reformierte Richtlinie im Stadt-Land- sowie im Ost-West-Vergleich auf die ambulante psychotherapeutische Arbeit und Versorgung auswirkt.
Methodik Eine Onlineumfrage unter vertragsärztlich tätigen TherapeutInnen wurde durchgeführt. Die Fragen bezogen sich auf verschiedene Neuerungen in der Richtlinie.
Ergebnisse Unabhängig von der Region schätzten die Befragten ein, dass die Reform zu keiner verbesserten Versorgung führte.
Im Westen und in der Stadt tätige TherapeutInnen verwiesen PatientInnen nach der Sprechstunde öfter an andere Psychotherapiepraxen, im Osten und auf dem Land tätige hingegen öfter auf andere Hilfeangebote.
Schlussfolgerung Stärkere Anreize für die psychotherapeutische Tätigkeit auf dem Land sind zu schaffen. Abbaumaßnahmen der Ost-West-Ungleichheiten in der Versorgungsdichte scheinen nötig.
N2 - Objective This article investigated whether or not the reformed psychotherapeutic guideline had different effects on outpatient psychotherapeutic work and services comparing urban and rural areas as well as eastern and western Germany.
Methods An online survey of psychotherapists was conducted. The survey included questions on various innovations within the reformed guideline.
Results Regardless of region, therapists stated overall that the reform has not led to improved psychotherapeutic care.
Therapists in the West and in urban areas referred more patients to other psychotherapeutic practices after their consultation. Therapists in the East and in rural areas referred more patients to other institutions and services.
Conclusions Psychotherapeutic work in rural areas should be better incentivized. Interventions to reduce east-west inequalities in the density of service provision seem to be necessary.
KW - Psychotherapierichtlinie
KW - Ostdeutschland
KW - Westdeutschland
KW - Stadt-Land-Vergleich
KW - psychotherapy guidelines
KW - Eastern-Western Germany
KW - urban-rural
KW - comparison
Y1 - 2020
U6 - https://doi.org/10.1055/a-1045-9820
SN - 0303-4259
SN - 1439-0876
VL - 47
IS - 07
SP - 383
EP - 387
PB - Thieme
CY - Stuttgart
ER -
TY - JOUR
A1 - Bangeow, Petjo
A1 - Rapp, Michael Armin
T1 - Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie
BT - Teil I: Vergleich unter den psychotherapeutischen Richtlinienverfahren
BT - Part I: A Comparison of the Psychotherapeutic Methods
JF - Psychiatrische Praxis
N2 - Objective This article investigates how aspects of 2016 reform of the German psychotherapeutic guideline were evaluated and used differently by therapists from three different psychotherapeutic treatment methods.
Methods An online survey was conducted with 987 statutory health insurance approved therapists. The questionnaire focused on various innovations in the guideline.
Results There were significant differences in the use of the broadened authority and of specific treatment services. There were also differences in the application for short-term and long-term psychotherapies as well as in the application to extend short to long-term psychotherapy.
Conclusions Elements of the guideline should be evaluated in relation to the preferred treatment method. Aspects related to the psychotherapeutic work with patients seem to be especially significant.
N2 - Ziel der Studie Dieser Artikel untersucht, inwiefern Aspekte der 2016 reformierten Psychotherapierichtlinie aus Sicht der drei Richtlinienverfahren für die praktische Arbeit unterschiedlich bewertet und genutzt werden.
Methodik Eine Onlineumfrage wurde unter vertragsärztlich tätigen PsychotherapeutInnen (n = 987) durchgeführt. Die Fragen bezogen sich auf die unterschiedlichen Neuerungen in der Psychotherapierichtlinie.
Ergebnisse Signifikante Unterschiede wurden u. a. in der Nutzung der erweiterten Befugnisse sowie in der Abrechnung bestimmter Leistungen deutlich. Die Gruppen unterschieden sich auch in der Beantragung von Behandlungskontingenten.
Schlussfolgerung Es scheint sinnvoll, Elemente der Richtlinienreform aus der Sicht des bevorzugten Behandlungsverfahrens zu evaluieren. Jene Aspekte scheinen bedeutsam, die sich auf die unmittelbare Arbeit mit den PatientInnen beziehen.
T2 - Assessment and Use of 2016 Reformed Psychotherapeutic Guideline
KW - Psychotherapierichtlinie
KW - Richtlinienverfahren
KW - Unterschiede
KW - psychotherapy guideline
KW - psychotherapy methods
KW - differences
Y1 - 2020
U6 - https://doi.org/10.1055/a-1045-9801
SN - 0303-4259
SN - 1439-0876
VL - 47
IS - 3
SP - 135
EP - 141
PB - Thieme
CY - Stuttgart
ER -
TY - JOUR
A1 - Bauer, M.
A1 - Banaschewski, Tobias
A1 - Heinz, A.
A1 - Kamp-Becker, I.
A1 - Meyer-Lindenberg, A.
A1 - Padberg, F.
A1 - Rapp, Michael Armin
A1 - Rupprecht, R.
A1 - Schneider, F.
A1 - Schulze, T. G.
A1 - Wittchen, Hans-Ulrich
T1 - The German Research Network for mental Disorders
JF - Der Nervenarzt : Organ der Deutschen Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft für Neurologie
N2 - Mental disorders are among the greatest medical and social challenges facing us. They can occur at all stages of life and are among the most important commonly occurring diseases. In Germany 28 % of the population suffer from a mental disorder every year, while the lifetime risk of suffering from a mental disorder is almost 50 %. Mental disorders cause great suffering for those affected and their social network. Quantitatively speaking, they can be considered to be among those diseases creating the greatest burden for society due to reduced productivity, absence from work and premature retirement. The Federal Ministry of Education and Research is funding a new research network from 2015 to 2019 with up to 35 million euros to investigate mental disorders in order to devise and develop better therapeutic measures and strategies for this population by means of basic and translational clinical research. This is the result of a competitive call for research proposals entitled research network for mental diseases. It is a nationwide network of nine consortia with up to ten psychiatric and clinical psychology partner institutions from largely university-based research facilities for adults and/or children and adolescents. Furthermore, three cross-consortia platform projects will seek to identify shared causes of diseases and new diagnostic modalities for anxiety disorders, attention deficit hyperactivity disorders (ADHS), autism, bipolar disorders, depression, schizophrenia and psychotic disorders as well as substance-related and addictive disorders. The spectrum of therapeutic approaches to be examined ranges from innovative pharmacological and psychotherapeutic treatment to novel brain stimulation procedures. In light of the enormous burden such diseases represent for society as a whole, a sustainable improvement in the financial support for those researching mental disorders seems essential. This network aims to become a nucleus for long overdue and sustained support for a German center for mental disorders.
Y1 - 2016
U6 - https://doi.org/10.1007/s00115-016-0169-y
SN - 0028-2804
SN - 1433-0407
VL - 87
SP - 989
EP - 1010
PB - Springer
CY - New York
ER -
TY - JOUR
A1 - Block, Andrea
A1 - Schulze, Susanne
A1 - Deeken, Friederike
A1 - Häusler, Andreas
A1 - Rezo, Anna
A1 - Rapp, Michael Armin
A1 - Wippert, Pia-Maria
T1 - Effects of inflammatory markers and biographical stress on treatment response in depression
JF - Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology
N2 - Background
Recent research emphasized the role of inflammatory processes in the pathophysiology of depression. Theories hypothesizes that life events (LE) can affect the immune system and trigger depressive symptoms. LE are also considered as one of the best predictors for the onset and course of depressive disorders.
Methods
Observational study across three treatment settings: n=208 depressive patients (75.5%f, M 46.6 y) were examined on depression (BDI-II), life events (ILE) and inflammatory markers (IL-6, CRP, fibrinogen, ICAM-1, TNF-alpha, E-selectin) at baseline (t0), 5-week(t1) and 5-month(t2) follow-up. Effects and interactions were analyzed with regression models.
Results
LE were associated with depressive symptoms at t0 (beta=.209; p=.002) and both follow-ups. Except for CRP, which was linked to depression symptoms at t2 (betai=-.190; p=.032), there were no effects of inflammatory markers on depressive symptoms. At t1, an interaction between CRP and LE in total (beta=-.249; p=.041) was found as well as for LE in the past five years (beta=-.122; p=.027). Similar interactions were found between cumulative LE and ICAM-1 (beta=-.197; p=.003) and IL-6 (beta=-.425; p=.001).
Conclusion
The cumulative burden of LE effects symptoms and treatment outcome in depressive patients. There is some evidence that inflammatory marker may have long-term effects on treatment outcome as they seem to weaken the determining relation between LE and depression.
Y1 - 2021
U6 - https://doi.org/10.1016/j.psyneuen.2021.105535
SN - 0306-4530
SN - 1873-3360
VL - 131
IS - Supplement
SP - S24
EP - S24
PB - Elsevier
CY - Oxford
ER -
TY - GEN
A1 - Bohle, Hannah
A1 - Rimpel, Jérôme
A1 - Schauenburg, Gesche
A1 - Gebel, Arnd
A1 - Stelzel, Christine
A1 - Heinzel, Stephan
A1 - Rapp, Michael Armin
A1 - Granacher, Urs
T1 - Behavioral and Neural Correlates of Cognitive-Motor Interference during Multitasking in Young and Old Adults
T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe
N2 - The concurrent performance of cognitive and postural tasks is particularly impaired in old adults and associated with an increased risk of falls. Biological aging of the cognitive and postural control system appears to be responsible for increased cognitive-motor interference effects. We examined neural and behavioral markers of motor-cognitive dual-task performance in young and old adults performing spatial one-back working memory single and dual tasks during semitandem stance. On the neural level, we used EEG to test for age-related modulations in the frequency domain related to cognitive-postural task load. Twenty-eight healthy young and 30 old adults participated in this study. The tasks included a postural single task, a cognitive-postural dual task, and a cognitive-postural triple task (cognitive dual-task with postural demands). Postural sway (i.e., total center of pressure displacements) was recorded in semistance position on an unstable surface that was placed on top of a force plate while performing cognitive tasks. Neural activation was recorded using a 64-channel mobile EEG system. EEG frequencies were attenuated by the baseline postural single-task condition and demarcated in nine Regions-of-Interest (ROIs), i.e., anterior, central, posterior, over the cortical midline, and both hemispheres. Our findings revealed impaired cognitive dual-task performance in old compared to young participants in the form of significantly lower cognitive performance in the triple-task condition. Furthermore, old adults compared with young adults showed significantly larger postural sway, especially in cognitive-postural task conditions. With respect to EEG frequencies, young compared to old participants showed significantly lower alpha-band activity in cognitive-cognitive-postural triple-task conditions compared with cognitive-postural dual tasks. In addition, with increasing task difficulty, we observed synchronized theta and delta frequencies, irrespective of age. Taskdependent alterations of the alpha frequency band were most pronounced over frontal and central ROIs, while alterations of the theta and delta frequency bands were found in frontal, central, and posterior ROIs. Theta and delta synchronization exhibited a decrease from anterior to posterior regions. For old adults, task difficulty was reflected by theta synchronization in the posterior ROI. For young adults, it was reflected by alpha desynchronization in bilateral anterior ROIs. In addition, we could not identify any effects of task difficulty and age on the beta frequency band. Our results shed light on age-related cognitive and postural declines and how they interact. Modulated alpha frequencies during high cognitive-postural task demands in young but not old adults might be reflective of a constrained neural adaptive potential in old adults. Future studies are needed to elucidate associations between the identified age-related performance decrements with task difficulty and changes in brain activity.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 563
Y1 - 2019
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435972
SN - 1866-8364
IS - 563
ER -
TY - JOUR
A1 - Bohle, Hannah
A1 - Rimpel, Jérôme
A1 - Schauenburg, Gesche
A1 - Gebel, Arnd
A1 - Stelzel, Christine
A1 - Heinzel, Stephan
A1 - Rapp, Michael Armin
A1 - Granacher, Urs
T1 - Behavioral and Neural Correlates of Cognitive-Motor Interference during Multitasking in Young and Old Adults
JF - Neural Plasticity
N2 - The concurrent performance of cognitive and postural tasks is particularly impaired in old adults and associated with an increased risk of falls. Biological aging of the cognitive and postural control system appears to be responsible for increased cognitive-motor interference effects. We examined neural and behavioral markers of motor-cognitive dual-task performance in young and old adults performing spatial one-back working memory single and dual tasks during semitandem stance. On the neural level, we used EEG to test for age-related modulations in the frequency domain related to cognitive-postural task load. Twenty-eight healthy young and 30 old adults participated in this study. The tasks included a postural single task, a cognitive-postural dual task, and a cognitive-postural triple task (cognitive dual-task with postural demands). Postural sway (i.e., total center of pressure displacements) was recorded in semistance position on an unstable surface that was placed on top of a force plate while performing cognitive tasks. Neural activation was recorded using a 64-channel mobile EEG system. EEG frequencies were attenuated by the baseline postural single-task condition and demarcated in nine Regions-of-Interest (ROIs), i.e., anterior, central, posterior, over the cortical midline, and both hemispheres. Our findings revealed impaired cognitive dual-task performance in old compared to young participants in the form of significantly lower cognitive performance in the triple-task condition. Furthermore, old adults compared with young adults showed significantly larger postural sway, especially in cognitive-postural task conditions. With respect to EEG frequencies, young compared to old participants showed significantly lower alpha-band activity in cognitive-cognitive-postural triple-task conditions compared with cognitive-postural dual tasks. In addition, with increasing task difficulty, we observed synchronized theta and delta frequencies, irrespective of age. Taskdependent alterations of the alpha frequency band were most pronounced over frontal and central ROIs, while alterations of the theta and delta frequency bands were found in frontal, central, and posterior ROIs. Theta and delta synchronization exhibited a decrease from anterior to posterior regions. For old adults, task difficulty was reflected by theta synchronization in the posterior ROI. For young adults, it was reflected by alpha desynchronization in bilateral anterior ROIs. In addition, we could not identify any effects of task difficulty and age on the beta frequency band. Our results shed light on age-related cognitive and postural declines and how they interact. Modulated alpha frequencies during high cognitive-postural task demands in young but not old adults might be reflective of a constrained neural adaptive potential in old adults. Future studies are needed to elucidate associations between the identified age-related performance decrements with task difficulty and changes in brain activity.
Y1 - 2019
U6 - https://doi.org/10.1155/2019/9478656
SN - 2090-5904
SN - 1687-5443
PB - Hindawi
CY - New York
ER -