TY  - JOUR
A1  - Pehlivanoglu, Tuna
A1  - Würtz-Kozak, Karin
A1  - Heider, Franziska
A1  - Sauer, Daniel
A1  - Wanke-Jellinek, Lorenz
A1  - Mayer, Michael
A1  - Mehren, Christoph
T1  - Clinical and Radiographic Outcome of Patients With Cervical Spondylotic Myelopathy Undergoing Total Disc Replacement
JF  - SPINE
N2  - Study Design. A nonrandomized, prospective, and single-center clinical trial. Objective. The aim of this study was to investigate the clinical and radiographic efficacy of ProDisc Vivo cervical total disc replacement (cTDR) in patients with clinical and radiographic documented cervical spondylotic myelopathy (CSM), due to degenerative changes at the index level. Summary of Background Data. Decompression and fusion is still the gold standard in patients with cervical myelopathy. Very limited data are available regarding the application of cTDR in patients with clinical and radiological documented CSM in context of clinical and radiographic outcomes. Methods. Clinical outcome scores included the Neck Disability Index (NDI), Visual Analogue Scale (VAS), arm and neck pain self-assessment questionnaires as well as the Nurick grade and the Japanese Orthopaedic Association (JOA) score. The radiological outcome included the range of motion (ROM), the segmental and global (C2-C7) lordosis, and the occurrence of heterotopic ossifications. Results. Eighteen consecutive patients (10 males, 8 females) with documented clinical and radiological signs of myelopathy were included in this investigation. The study population had a mean age of 52.4 years and a follow-up period of 20.3 months in average (range 3-48 months). The mean range ROM of the index level stayed consistent with 6.8 degrees preoperatively and 7.2 degrees (P = 0.578) at the last follow-up; the global lordosis in neutral position changed from 3.5 degrees to 14.2 degrees significantly (P = 0.005) in mean. The JOA score improved from 11.3 to 16.6 (P < 0.001) as well as the NDI 36.7 to 10.3 (P < 0.001) and the VAS score from 5.7/6.1 (arm/neck) to 1.3/2.0 (P P < 0.001). The mean Nurick grade was 1.33 preoperatively and dropped down in all cases to Nurick grade of 0 (P < 0.001). Conclusion. cTDR (with ProDisc Vivio) in patients with CSM yielded good clinical and radiographic outcomes and found as a reliable, safe, and motion-preserving surgical treatment option, although its indication is very limited due to numerous exclusion criteria.
KW  - cervical myelopathy
KW  - cervical total disc replacement
KW  - disc arthroplasty
KW  - ProDisc Vivo
Y1  - 2019
U6  - https://doi.org/10.1097/BRS.0000000000003079
SN  - 0362-2436
SN  - 1528-1159
VL  - 44
IS  - 20
SP  - 1403
EP  - 1411
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Mayer, Magnus C.
A1  - Schauenburg, Linda
A1  - Thompson-Steckel, Greta
A1  - Dunsing, Valentin
A1  - Kaden, Daniela
A1  - Voigt, Philipp
A1  - Schaefer, Michael
A1  - Chiantia, Salvatore
A1  - Kennedy, Timothy E.
A1  - Multhaup, Gerhard
T1  - Amyloid precursor-like protein 1 (APLP1) exhibits stronger
zinc-dependent neuronal adhesion than amyloid precursor protein and
APLP2
JF  - Journal of neurochemistry
N2  - The amyloid precursor protein (APP) and its paralogs, amyloid precursor-like protein 1 (APLP1) and APLP2, are metalloproteins with a putative role both in synaptogenesis and in maintaining synapse structure. Here, we studied the effect of zinc on membrane localization, adhesion, and secretase cleavage of APP, APLP1, and APLP2 in cell culture and rat neurons. For this, we employed live-cell microscopy techniques, a microcontact printing adhesion assay and ELISA for protein detection in cell culture supernatants. We report that zinc induces the multimerization of proteins of the amyloid precursor protein family and enriches them at cellular adhesion sites. Thus, zinc facilitates the formation of de novo APP and APLP1 containing adhesion complexes, whereas it does not have such influence on APLP2. Furthermore, zinc-binding prevented cleavage of APP and APLPs by extracellular secretases. In conclusion, the complexation of zinc modulates neuronal functions of APP and APLPs by (i) regulating formation of adhesion complexes, most prominently for APLP1, and (ii) by reducing the concentrations of neurotrophic soluble APP/APLP ectodomains.
KW  - amyloid precursor protein
KW  - amyloid precursor-like protein
KW  - neuronal adhesion
KW  - number and brightness
KW  - zinc
Y1  - 2016
U6  - https://doi.org/10.1111/jnc.13540
SN  - 0022-3042
SN  - 1471-4159
VL  - 137
SP  - 266
EP  - 276
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Dolch, D.
A1  - Batsaikhan, Nyamsuren
A1  - Thiele, K.
A1  - Burger, F.
A1  - Scheffler, Ingo
A1  - Kiefer, A.
A1  - Mayer, Frank
A1  - Samjaa, R.
A1  - Stubbe, Annegret
A1  - Stubbe, Michael
A1  - Krall, L.
A1  - Steinhauser, D.
T1  - Contributions to the chiroptera of Mongolia with first evidences on species communities and ecological niches
Y1  - 2007
SN  - 0440-1298
ER  -