TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Arnison, Paul G.
A1  - Bibb, Mervyn J.
A1  - Bierbaum, Gabriele
A1  - Bowers, Albert A.
A1  - Bugni, Tim S.
A1  - Bulaj, Grzegorz
A1  - Camarero, Julio A.
A1  - Campopiano, Dominic J.
A1  - Challis, Gregory L.
A1  - Clardy, Jon
A1  - Cotter, Paul D.
A1  - Craik, David J.
A1  - Dawson, Michael
A1  - Dittmann-Thünemann, Elke
A1  - Donadio, Stefano
A1  - Dorrestein, Pieter C.
A1  - Entian, Karl-Dieter
A1  - Fischbach, Michael A.
A1  - Garavelli, John S.
A1  - Goeransson, Ulf
A1  - Gruber, Christian W.
A1  - Haft, Daniel H.
A1  - Hemscheidt, Thomas K.
A1  - Hertweck, Christian
A1  - Hill, Colin
A1  - Horswill, Alexander R.
A1  - Jaspars, Marcel
A1  - Kelly, Wendy L.
A1  - Klinman, Judith P.
A1  - Kuipers, Oscar P.
A1  - Link, A. James
A1  - Liu, Wen
A1  - Marahiel, Mohamed A.
A1  - Mitchell, Douglas A.
A1  - Moll, Gert N.
A1  - Moore, Bradley S.
A1  - Mueller, Rolf
A1  - Nair, Satish K.
A1  - Nes, Ingolf F.
A1  - Norris, Gillian E.
A1  - Olivera, Baldomero M.
A1  - Onaka, Hiroyasu
A1  - Patchett, Mark L.
A1  - Piel, Jörn
A1  - Reaney, Martin J. T.
A1  - Rebuffat, Sylvie
A1  - Ross, R. Paul
A1  - Sahl, Hans-Georg
A1  - Schmidt, Eric W.
A1  - Selsted, Michael E.
A1  - Severinov, Konstantin
A1  - Shen, Ben
A1  - Sivonen, Kaarina
A1  - Smith, Leif
A1  - Stein, Torsten
A1  - Suessmuth, Roderich D.
A1  - Tagg, John R.
A1  - Tang, Gong-Li
A1  - Truman, Andrew W.
A1  - Vederas, John C.
A1  - Walsh, Christopher T.
A1  - Walton, Jonathan D.
A1  - Wenzel, Silke C.
A1  - Willey, Joanne M.
A1  - van der Donk, Wilfred A.
T1  - Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature
JF  - Natural product reports : a journal of current developments in bio-organic chemistry
N2  - This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
Y1  - 2013
U6  - https://doi.org/10.1039/c2np20085f
SN  - 0265-0568
VL  - 30
IS  - 1
SP  - 108
EP  - 160
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Warrington, Nicole
A1  - Beaumont, Robin
A1  - Horikoshi, Momoko
A1  - Day, Felix R.
A1  - Helgeland, Øyvind
A1  - Laurin, Charles
A1  - Bacelis, Jonas
A1  - Peng, Shouneng
A1  - Hao, Ke
A1  - Feenstra, Bjarke
A1  - Wood, Andrew R.
A1  - Mahajan, Anubha
A1  - Tyrrell, Jessica
A1  - Robertson, Neil R.
A1  - Rayner, N. William
A1  - Qiao, Zhen
A1  - Moen, Gunn-Helen
A1  - Vaudel, Marc
A1  - Marsit, Carmen
A1  - Chen, Jia
A1  - Nodzenski, Michael
A1  - Schnurr, Theresia M.
A1  - Zafarmand, Mohammad Hadi
A1  - Bradfield, Jonathan P.
A1  - Grarup, Niels
A1  - Kooijman, Marjolein N.
A1  - Li-Gao, Ruifang
A1  - Geller, Frank
A1  - Ahluwalia, Tarunveer Singh
A1  - Paternoster, Lavinia
A1  - Rueedi, Rico
A1  - Huikari, Ville
A1  - Hottenga, Jouke-Jan
A1  - Lyytikäinen, Leo-Pekka
A1  - Cavadino, Alana
A1  - Metrustry, Sarah
A1  - Cousminer, Diana L.
A1  - Wu, Ying
A1  - Thiering, Elisabeth Paula
A1  - Wang, Carol A.
A1  - Have, Christian Theil
A1  - Vilor-Tejedor, Natalia
A1  - Joshi, Peter K.
A1  - Painter, Jodie N.
A1  - Ntalla, Ioanna
A1  - Myhre, Ronny
A1  - Pitkänen, Niina
A1  - van Leeuwen, Elisabeth M.
A1  - Joro, Raimo
A1  - Lagou, Vasiliki
A1  - Richmond, Rebecca C.
A1  - Espinosa, Ana
A1  - Barton, Sheila J.
A1  - Inskip, Hazel M.
A1  - Holloway, John W.
A1  - Santa-Marina, Loreto
A1  - Estivill, Xavier
A1  - Ang, Wei
A1  - Marsh, Julie A.
A1  - Reichetzeder, Christoph
A1  - Marullo, Letizia
A1  - Hocher, Berthold
A1  - Lunetta, Kathryn L.
A1  - Murabito, Joanne M.
A1  - Relton, Caroline L.
A1  - Kogevinas, Manolis
A1  - Chatzi, Leda
A1  - Allard, Catherine
A1  - Bouchard, Luigi
A1  - Hivert, Marie-France
A1  - Zhang, Ge
A1  - Muglia, Louis J.
A1  - Heikkinen, Jani
A1  - Morgen, Camilla S.
A1  - van Kampen, Antoine H. C.
A1  - van Schaik, Barbera D. C.
A1  - Mentch, Frank D.
A1  - Langenberg, Claudia
A1  - Scott, Robert A.
A1  - Zhao, Jing Hua
A1  - Hemani, Gibran
A1  - Ring, Susan M.
A1  - Bennett, Amanda J.
A1  - Gaulton, Kyle J.
A1  - Fernandez-Tajes, Juan
A1  - van Zuydam, Natalie R.
A1  - Medina-Gomez, Carolina
A1  - de Haan, Hugoline G.
A1  - Rosendaal, Frits R.
A1  - Kutalik, Zoltán
A1  - Marques-Vidal, Pedro
A1  - Das, Shikta
A1  - Willemsen, Gonneke
A1  - Mbarek, Hamdi
A1  - Müller-Nurasyid, Martina
A1  - Standl, Marie
A1  - Appel, Emil V. R.
A1  - Fonvig, Cilius Esmann
A1  - Trier, Caecilie
A1  - van Beijsterveldt, Catharina E. M.
A1  - Murcia, Mario
A1  - Bustamante, Mariona
A1  - Bonàs-Guarch, Sílvia
A1  - Hougaard, David M.
A1  - Mercader, Josep M.
A1  - Linneberg, Allan
A1  - Schraut, Katharina E.
A1  - Lind, Penelope A.
A1  - Medland, Sarah Elizabeth
A1  - Shields, Beverley M.
A1  - Knight, Bridget A.
A1  - Chai, Jin-Fang
A1  - Panoutsopoulou, Kalliope
A1  - Bartels, Meike
A1  - Sánchez, Friman
A1  - Stokholm, Jakob
A1  - Torrents, David
A1  - Vinding, Rebecca K.
A1  - Willems, Sara M.
A1  - Atalay, Mustafa
A1  - Chawes, Bo L.
A1  - Kovacs, Peter
A1  - Prokopenko, Inga
A1  - Tuke, Marcus A.
A1  - Yaghootkar, Hanieh
A1  - Ruth, Katherine S.
A1  - Jones, Samuel E.
A1  - Loh, Po-Ru
A1  - Murray, Anna
A1  - Weedon, Michael N.
A1  - Tönjes, Anke
A1  - Stumvoll, Michael
A1  - Michaelsen, Kim Fleischer
A1  - Eloranta, Aino-Maija
A1  - Lakka, Timo A.
A1  - van Duijn, Cornelia M.
A1  - Kiess, Wieland
A1  - Koerner, Antje
A1  - Niinikoski, Harri
A1  - Pahkala, Katja
A1  - Raitakari, Olli T.
A1  - Jacobsson, Bo
A1  - Zeggini, Eleftheria
A1  - Dedoussis, George V.
A1  - Teo, Yik-Ying
A1  - Saw, Seang-Mei
A1  - Montgomery, Grant W.
A1  - Campbell, Harry
A1  - Wilson, James F.
A1  - Vrijkotte, Tanja G. M.
A1  - Vrijheid, Martine
A1  - de Geus, Eco J. C. N.
A1  - Hayes, M. Geoffrey
A1  - Kadarmideen, Haja N.
A1  - Holm, Jens-Christian
A1  - Beilin, Lawrence J.
A1  - Pennell, Craig E.
A1  - Heinrich, Joachim
A1  - Adair, Linda S.
A1  - Borja, Judith B.
A1  - Mohlke, Karen L.
A1  - Eriksson, Johan G.
A1  - Widen, Elisabeth E.
A1  - Hattersley, Andrew T.
A1  - Spector, Tim D.
A1  - Kaehoenen, Mika
A1  - Viikari, Jorma S.
A1  - Lehtimaeki, Terho
A1  - Boomsma, Dorret I.
A1  - Sebert, Sylvain
A1  - Vollenweider, Peter
A1  - Sorensen, Thorkild I. A.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Murray, Jeffrey C.
A1  - Melbye, Mads
A1  - Nohr, Ellen A.
A1  - Mook-Kanamori, Dennis O.
A1  - Rivadeneira, Fernando
A1  - Hofman, Albert
A1  - Felix, Janine F.
A1  - Jaddoe, Vincent W. V.
A1  - Hansen, Torben
A1  - Pisinger, Charlotta
A1  - Vaag, Allan A.
A1  - Pedersen, Oluf
A1  - Uitterlinden, Andre G.
A1  - Jarvelin, Marjo-Riitta
A1  - Power, Christine
A1  - Hypponen, Elina
A1  - Scholtens, Denise M.
A1  - Lowe, William L.
A1  - Smith, George Davey
A1  - Timpson, Nicholas J.
A1  - Morris, Andrew P.
A1  - Wareham, Nicholas J.
A1  - Hakonarson, Hakon
A1  - Grant, Struan F. A.
A1  - Frayling, Timothy M.
A1  - Lawlor, Debbie A.
A1  - Njolstad, Pal R.
A1  - Johansson, Stefan
A1  - Ong, Ken K.
A1  - McCarthy, Mark I.
A1  - Perry, John R. B.
A1  - Evans, David M.
A1  - Freathy, Rachel M.
T1  - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
JF  - Nature genetics
N2  - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Y1  - 2019
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 5
SP  - 804
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Tiegs, Scott D.
A1  - Costello, David M.
A1  - Isken, Mark W.
A1  - Woodward, Guy
A1  - McIntyre, Peter B.
A1  - Gessner, Mark O.
A1  - Chauvet, Eric
A1  - Griffiths, Natalie A.
A1  - Flecker, Alex S.
A1  - Acuna, Vicenc
A1  - Albarino, Ricardo
A1  - Allen, Daniel C.
A1  - Alonso, Cecilia
A1  - Andino, Patricio
A1  - Arango, Clay
A1  - Aroviita, Jukka
A1  - Barbosa, Marcus V. M.
A1  - Barmuta, Leon A.
A1  - Baxter, Colden V.
A1  - Bell, Thomas D. C.
A1  - Bellinger, Brent
A1  - Boyero, Luz
A1  - Brown, Lee E.
A1  - Bruder, Andreas
A1  - Bruesewitz, Denise A.
A1  - Burdon, Francis J.
A1  - Callisto, Marcos
A1  - Canhoto, Cristina
A1  - Capps, Krista A.
A1  - Castillo, Maria M.
A1  - Clapcott, Joanne
A1  - Colas, Fanny
A1  - Colon-Gaud, Checo
A1  - Cornut, Julien
A1  - Crespo-Perez, Veronica
A1  - Cross, Wyatt F.
A1  - Culp, Joseph M.
A1  - Danger, Michael
A1  - Dangles, Olivier
A1  - de Eyto, Elvira
A1  - Derry, Alison M.
A1  - Diaz Villanueva, Veronica
A1  - Douglas, Michael M.
A1  - Elosegi, Arturo
A1  - Encalada, Andrea C.
A1  - Entrekin, Sally
A1  - Espinosa, Rodrigo
A1  - Ethaiya, Diana
A1  - Ferreira, Veronica
A1  - Ferriol, Carmen
A1  - Flanagan, Kyla M.
A1  - Fleituch, Tadeusz
A1  - Shah, Jennifer J. Follstad
A1  - Frainer, Andre
A1  - Friberg, Nikolai
A1  - Frost, Paul C.
A1  - Garcia, Erica A.
A1  - Lago, Liliana Garcia
A1  - Garcia Soto, Pavel Ernesto
A1  - Ghate, Sudeep
A1  - Giling, Darren P.
A1  - Gilmer, Alan
A1  - Goncalves, Jose Francisco
A1  - Gonzales, Rosario Karina
A1  - Graca, Manuel A. S.
A1  - Grace, Mike
A1  - Grossart, Hans-Peter
A1  - Guerold, Francois
A1  - Gulis, Vlad
A1  - Hepp, Luiz U.
A1  - Higgins, Scott
A1  - Hishi, Takuo
A1  - Huddart, Joseph
A1  - Hudson, John
A1  - Imberger, Samantha
A1  - Iniguez-Armijos, Carlos
A1  - Iwata, Tomoya
A1  - Janetski, David J.
A1  - Jennings, Eleanor
A1  - Kirkwood, Andrea E.
A1  - Koning, Aaron A.
A1  - Kosten, Sarian
A1  - Kuehn, Kevin A.
A1  - Laudon, Hjalmar
A1  - Leavitt, Peter R.
A1  - Lemes da Silva, Aurea L.
A1  - Leroux, Shawn J.
A1  - Leroy, Carri J.
A1  - Lisi, Peter J.
A1  - MacKenzie, Richard
A1  - Marcarelli, Amy M.
A1  - Masese, Frank O.
A1  - Mckie, Brendan G.
A1  - Oliveira Medeiros, Adriana
A1  - Meissner, Kristian
A1  - Milisa, Marko
A1  - Mishra, Shailendra
A1  - Miyake, Yo
A1  - Moerke, Ashley
A1  - Mombrikotb, Shorok
A1  - Mooney, Rob
A1  - Moulton, Tim
A1  - Muotka, Timo
A1  - Negishi, Junjiro N.
A1  - Neres-Lima, Vinicius
A1  - Nieminen, Mika L.
A1  - Nimptsch, Jorge
A1  - Ondruch, Jakub
A1  - Paavola, Riku
A1  - Pardo, Isabel
A1  - Patrick, Christopher J.
A1  - Peeters, Edwin T. H. M.
A1  - Pozo, Jesus
A1  - Pringle, Catherine
A1  - Prussian, Aaron
A1  - Quenta, Estefania
A1  - Quesada, Antonio
A1  - Reid, Brian
A1  - Richardson, John S.
A1  - Rigosi, Anna
A1  - Rincon, Jose
A1  - Risnoveanu, Geta
A1  - Robinson, Christopher T.
A1  - Rodriguez-Gallego, Lorena
A1  - Royer, Todd V.
A1  - Rusak, James A.
A1  - Santamans, Anna C.
A1  - Selmeczy, Geza B.
A1  - Simiyu, Gelas
A1  - Skuja, Agnija
A1  - Smykla, Jerzy
A1  - Sridhar, Kandikere R.
A1  - Sponseller, Ryan
A1  - Stoler, Aaron
A1  - Swan, Christopher M.
A1  - Szlag, David
A1  - Teixeira-de Mello, Franco
A1  - Tonkin, Jonathan D.
A1  - Uusheimo, Sari
A1  - Veach, Allison M.
A1  - Vilbaste, Sirje
A1  - Vought, Lena B. M.
A1  - Wang, Chiao-Ping
A1  - Webster, Jackson R.
A1  - Wilson, Paul B.
A1  - Woelfl, Stefan
A1  - Xenopoulos, Marguerite A.
A1  - Yates, Adam G.
A1  - Yoshimura, Chihiro
A1  - Yule, Catherine M.
A1  - Zhang, Yixin X.
A1  - Zwart, Jacob A.
T1  - Global patterns and drivers of ecosystem functioning in rivers and riparian zones
JF  - Science Advances
N2  - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Y1  - 2019
U6  - https://doi.org/10.1126/sciadv.aav0486
SN  - 2375-2548
VL  - 5
IS  - 1
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Van Hout, Cristopher V.
A1  - Tachmazidou, Ioanna
A1  - Backman, Joshua D.
A1  - Hoffman, Joshua D.
A1  - Liu, Daren
A1  - Pandey, Ashutosh K.
A1  - Gonzaga-Jauregui, Claudia
A1  - Khalid, Shareef
A1  - Ye, Bin
A1  - Banerjee, Nilanjana
A1  - Li, Alexander H.
A1  - O'Dushlaine, Colm
A1  - Marcketta, Anthony
A1  - Staples, Jeffrey
A1  - Schurmann, Claudia
A1  - Hawes, Alicia
A1  - Maxwell, Evan
A1  - Barnard, Leland
A1  - Lopez, Alexander
A1  - Penn, John
A1  - Habegger, Lukas
A1  - Blumenfeld, Andrew L.
A1  - Bai, Xiaodong
A1  - O'Keeffe, Sean
A1  - Yadav, Ashish
A1  - Praveen, Kavita
A1  - Jones, Marcus
A1  - Salerno, William J.
A1  - Chung, Wendy K.
A1  - Surakka, Ida
A1  - Willer, Cristen J.
A1  - Hveem, Kristian
A1  - Leader, Joseph B.
A1  - Carey, David J.
A1  - Ledbetter, David H.
A1  - Cardon, Lon
A1  - Yancopoulos, George D.
A1  - Economides, Aris
A1  - Coppola, Giovanni
A1  - Shuldiner, Alan R.
A1  - Balasubramanian, Suganthi
A1  - Cantor, Michael
A1  - Nelson, Matthew R.
A1  - Whittaker, John
A1  - Reid, Jeffrey G.
A1  - Marchini, Jonathan
A1  - Overton, John D.
A1  - Scott, Robert A.
A1  - Abecasis, Goncalo R.
A1  - Yerges-Armstrong, Laura M.
A1  - Baras, Aris
T1  - Exome sequencing and characterization of 49,960 individuals in the UK Biobank
JF  - Nature : the international weekly journal of science
N2  - The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world(1). Here we describe the release of exome-sequence data for the first 49,960 study participants, revealing approximately 4 million coding variants (of which around 98.6% have a frequency of less than 1%). The data include 198,269 autosomal predicted loss-of-function (LOF) variants, a more than 14-fold increase compared to the imputed sequence. Nearly all genes (more than 97%) had at least one carrier with a LOF variant, and most genes (more than 69%) had at least ten carriers with a LOF variant. We illustrate the power of characterizing LOF variants in this population through association analyses across 1,730 phenotypes. In addition to replicating established associations, we found novel LOF variants with large effects on disease traits, includingPIEZO1on varicose veins,COL6A1on corneal resistance,MEPEon bone density, andIQGAP2andGMPRon blood cell traits. We further demonstrate the value of exome sequencing by surveying the prevalence of pathogenic variants of clinical importance, and show that 2% of this population has a medically actionable variant. Furthermore, we characterize the penetrance of cancer in carriers of pathogenicBRCA1andBRCA2variants. Exome sequences from the first 49,960 participants highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community. <br /> Exome sequences from the first 49,960 participants in the UK Biobank highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community.
KW  - clinical exome
KW  - breast-cancer
KW  - mutations
KW  - recommendations
KW  - gene
KW  - metaanalysis
KW  - variants,
KW  - BRCA1
KW  - risk
KW  - susceptibility
Y1  - 2020
U6  - https://doi.org/10.1038/s41586-020-2853-0
SN  - 0028-0836
SN  - 1476-4687
VL  - 586
IS  - 7831
SP  - 749
EP  - 756
PB  - Macmillan Publishers Limited
CY  - London
ER  - 
TY  - JOUR
A1  - Beaulieu, Jean-Philippe
A1  - Bennett, David P.
A1  - Fouqué, Pascal
A1  - Williams, Andrew
A1  - Dominik, Martin
A1  - Jorgensen, Uffe Grae
A1  - Kubas, Daniel
A1  - Cassan, Arnaud
A1  - Coutures, Christian
A1  - Greenhill, John
A1  - Hill, Kym
A1  - Menzies, John
A1  - Sackett, Penny D.
A1  - Albrow, Michael D.
A1  - Brillant, Stephane
A1  - Caldwell, John A. R.
A1  - Calitz, Johannes Jacobus
A1  - Cook, Kem H.
A1  - Corrales Cosmeli, Esperanza de Santa Cecilia
A1  - Desort, Morgan
A1  - Dieters, Stefan
A1  - Dominis, Dijana
A1  - Donatowicz, Jadzia
A1  - Hoffman, Martie
A1  - Kane, Stephen R.
A1  - Marquette, Jean-Baptiste
A1  - Martin, Ralph
A1  - Meintjes, Pieter
A1  - Pollard, Karen R.
A1  - Sahu, Kailash C.
A1  - Vinter, Christian
A1  - Wambsganss, Joachim
A1  - Woller, Kristian
A1  - Horne, Keith
A1  - Steele, Iain
A1  - Bramich, Daniel M.
A1  - Burgdorf, Martin
A1  - Snodgrass, Colin
A1  - Bode, Mike
A1  - Udalski, Andr
T1  - Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing
N2  - In the favoured core-accretion model of formation of planetary systems, solid planetesimals accumulate to build up planetary cores, which then accrete nebular gas if they are sufficiently massive. Around M-dwarf stars ( the most common stars in our Galaxy), this model favours the formation of Earth-mass (M+) to Neptune-mass planets with orbital radii of 1 to 10 astronomical units (AU), which is consistent with the small number of gas giant planets known to orbit M-dwarf host stars(1-4). More than 170 extrasolar planets have been discovered with a wide range of masses and orbital periods, but planets of Neptune's mass or less have not hitherto been detected at separations of more than 0.15 AU from normal stars. Here we report the discovery of a 5.5(-2.7)(+5.5)M(+) planetary companion at a separation of 2.6(- 0.6)(+1.5) AU from a 0.22(-0.11)(+0.21)M(.) M-dwarf star, where M-. refers to a solar mass. (We propose to name it OGLE- 2005-BLG-390Lb, indicating a planetary mass companion to the lens star of the microlensing event.) The mass is lower than that of GJ876d (ref. 5), although the error bars overlap. Our detection suggests that such cool, sub-Neptune-mass planets may be more common than gas giant planets, as predicted by the core accretion theory.
Y1  - 2006
UR  - http://www.nature.com/nature/
U6  - https://doi.org/10.1038/Nature04441
SN  - 0028-0836
ER  - 
TY  - JOUR
A1  - Horikoshi, Momoko
A1  - Yaghootkar, Hanieh
A1  - Mook-Kanamori, Dennis O.
A1  - Sovio, Ulla
A1  - Taal, H. Rob
A1  - Hennig, Branwen J.
A1  - Bradfield, Jonathan P.
A1  - St Pourcain, Beate
A1  - Evans, David M.
A1  - Charoen, Pimphen
A1  - Kaakinen, Marika
A1  - Cousminer, Diana L.
A1  - Lehtimaki, Terho
A1  - Kreiner-Moller, Eskil
A1  - Warrington, Nicole M.
A1  - Bustamante, Mariona
A1  - Feenstra, Bjarke
A1  - Berry, Diane J.
A1  - Thiering, Elisabeth
A1  - Pfab, Thiemo
A1  - Barton, Sheila J.
A1  - Shields, Beverley M.
A1  - Kerkhof, Marjan
A1  - van Leeuwen, Elisabeth M.
A1  - Fulford, Anthony J.
A1  - Kutalik, Zoltan
A1  - Zhao, Jing Hua
A1  - den Hoed, Marcel
A1  - Mahajan, Anubha
A1  - Lindi, Virpi
A1  - Goh, Liang-Kee
A1  - Hottenga, Jouke-Jan
A1  - Wu, Ying
A1  - Raitakari, Olli T.
A1  - Harder, Marie N.
A1  - Meirhaeghe, Aline
A1  - Ntalla, Ioanna
A1  - Salem, Rany M.
A1  - Jameson, Karen A.
A1  - Zhou, Kaixin
A1  - Monies, Dorota M.
A1  - Lagou, Vasiliki
A1  - Kirin, Mirna
A1  - Heikkinen, Jani
A1  - Adair, Linda S.
A1  - Alkuraya, Fowzan S.
A1  - Al-Odaib, Ali
A1  - Amouyel, Philippe
A1  - Andersson, Ehm Astrid
A1  - Bennett, Amanda J.
A1  - Blakemore, Alexandra I. F.
A1  - Buxton, Jessica L.
A1  - Dallongeville, Jean
A1  - Das, Shikta
A1  - de Geus, Eco J. C.
A1  - Estivill, Xavier
A1  - Flexeder, Claudia
A1  - Froguel, Philippe
A1  - Geller, Frank
A1  - Godfrey, Keith M.
A1  - Gottrand, Frederic
A1  - Groves, Christopher J.
A1  - Hansen, Torben
A1  - Hirschhorn, Joel N.
A1  - Hofman, Albert
A1  - Hollegaard, Mads V.
A1  - Hougaard, David M.
A1  - Hyppoenen, Elina
A1  - Inskip, Hazel M.
A1  - Isaacs, Aaron
A1  - Jorgensen, Torben
A1  - Kanaka-Gantenbein, Christina
A1  - Kemp, John P.
A1  - Kiess, Wieland
A1  - Kilpelainen, Tuomas O.
A1  - Klopp, Norman
A1  - Knight, Bridget A.
A1  - Kuzawa, Christopher W.
A1  - McMahon, George
A1  - Newnham, John P.
A1  - Niinikoski, Harri
A1  - Oostra, Ben A.
A1  - Pedersen, Louise
A1  - Postma, Dirkje S.
A1  - Ring, Susan M.
A1  - Rivadeneira, Fernando
A1  - Robertson, Neil R.
A1  - Sebert, Sylvain
A1  - Simell, Olli
A1  - Slowinski, Torsten
A1  - Tiesler, Carla M. T.
A1  - Toenjes, Anke
A1  - Vaag, Allan
A1  - Viikari, Jorma S.
A1  - Vink, Jacqueline M.
A1  - Vissing, Nadja Hawwa
A1  - Wareham, Nicholas J.
A1  - Willemsen, Gonneke
A1  - Witte, Daniel R.
A1  - Zhang, Haitao
A1  - Zhao, Jianhua
A1  - Wilson, James F.
A1  - Stumvoll, Michael
A1  - Prentice, Andrew M.
A1  - Meyer, Brian F.
A1  - Pearson, Ewan R.
A1  - Boreham, Colin A. G.
A1  - Cooper, Cyrus
A1  - Gillman, Matthew W.
A1  - Dedoussis, George V.
A1  - Moreno, Luis A.
A1  - Pedersen, Oluf
A1  - Saarinen, Maiju
A1  - Mohlke, Karen L.
A1  - Boomsma, Dorret I.
A1  - Saw, Seang-Mei
A1  - Lakka, Timo A.
A1  - Koerner, Antje
A1  - Loos, Ruth J. F.
A1  - Ong, Ken K.
A1  - Vollenweider, Peter
A1  - van Duijn, Cornelia M.
A1  - Koppelman, Gerard H.
A1  - Hattersley, Andrew T.
A1  - Holloway, John W.
A1  - Hocher, Berthold
A1  - Heinrich, Joachim
A1  - Power, Chris
A1  - Melbye, Mads
A1  - Guxens, Monica
A1  - Pennell, Craig E.
A1  - Bonnelykke, Klaus
A1  - Bisgaard, Hans
A1  - Eriksson, Johan G.
A1  - Widen, Elisabeth
A1  - Hakonarson, Hakon
A1  - Uitterlinden, Andre G.
A1  - Pouta, Anneli
A1  - Lawlor, Debbie A.
A1  - Smith, George Davey
A1  - Frayling, Timothy M.
A1  - McCarthy, Mark I.
A1  - Grant, Struan F. A.
A1  - Jaddoe, Vincent W. V.
A1  - Jarvelin, Marjo-Riitta
A1  - Timpson, Nicholas J.
A1  - Prokopenko, Inga
A1  - Freathy, Rachel M.
T1  - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
JF  - Nature genetics
N2  - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Y1  - 2013
U6  - https://doi.org/10.1038/ng.2477
SN  - 1061-4036
VL  - 45
IS  - 1
SP  - 76
EP  - U115
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Banks, Jo Ann
A1  - Nishiyama, Tomoaki
A1  - Hasebe, Mitsuyasu
A1  - Bowman, John L.
A1  - Gribskov, Michael
A1  - dePamphilis, Claude
A1  - Albert, Victor A.
A1  - Aono, Naoki
A1  - Aoyama, Tsuyoshi
A1  - Ambrose, Barbara A.
A1  - Ashton, Neil W.
A1  - Axtell, Michael J.
A1  - Barker, Elizabeth
A1  - Barker, Michael S.
A1  - Bennetzen, Jeffrey L.
A1  - Bonawitz, Nicholas D.
A1  - Chapple, Clint
A1  - Cheng, Chaoyang
A1  - Correa, Luiz Gustavo Guedes
A1  - Dacre, Michael
A1  - DeBarry, Jeremy
A1  - Dreyer, Ingo
A1  - Elias, Marek
A1  - Engstrom, Eric M.
A1  - Estelle, Mark
A1  - Feng, Liang
A1  - Finet, Cedric
A1  - Floyd, Sandra K.
A1  - Frommer, Wolf B.
A1  - Fujita, Tomomichi
A1  - Gramzow, Lydia
A1  - Gutensohn, Michael
A1  - Harholt, Jesper
A1  - Hattori, Mitsuru
A1  - Heyl, Alexander
A1  - Hirai, Tadayoshi
A1  - Hiwatashi, Yuji
A1  - Ishikawa, Masaki
A1  - Iwata, Mineko
A1  - Karol, Kenneth G.
A1  - Koehler, Barbara
A1  - Kolukisaoglu, Uener
A1  - Kubo, Minoru
A1  - Kurata, Tetsuya
A1  - Lalonde, Sylvie
A1  - Li, Kejie
A1  - Li, Ying
A1  - Litt, Amy
A1  - Lyons, Eric
A1  - Manning, Gerard
A1  - Maruyama, Takeshi
A1  - Michael, Todd P.
A1  - Mikami, Koji
A1  - Miyazaki, Saori
A1  - Morinaga, Shin-ichi
A1  - Murata, Takashi
A1  - Müller-Röber, Bernd
A1  - Nelson, David R.
A1  - Obara, Mari
A1  - Oguri, Yasuko
A1  - Olmstead, Richard G.
A1  - Onodera, Naoko
A1  - Petersen, Bent Larsen
A1  - Pils, Birgit
A1  - Prigge, Michael
A1  - Rensing, Stefan A.
A1  - Mauricio Riano-Pachon, Diego
A1  - Roberts, Alison W.
A1  - Sato, Yoshikatsu
A1  - Scheller, Henrik Vibe
A1  - Schulz, Burkhard
A1  - Schulz, Christian
A1  - Shakirov, Eugene V.
A1  - Shibagaki, Nakako
A1  - Shinohara, Naoki
A1  - Shippen, Dorothy E.
A1  - Sorensen, Iben
A1  - Sotooka, Ryo
A1  - Sugimoto, Nagisa
A1  - Sugita, Mamoru
A1  - Sumikawa, Naomi
A1  - Tanurdzic, Milos
A1  - Theissen, Guenter
A1  - Ulvskov, Peter
A1  - Wakazuki, Sachiko
A1  - Weng, Jing-Ke
A1  - Willats, William W. G. T.
A1  - Wipf, Daniel
A1  - Wolf, Paul G.
A1  - Yang, Lixing
A1  - Zimmer, Andreas D.
A1  - Zhu, Qihui
A1  - Mitros, Therese
A1  - Hellsten, Uffe
A1  - Loque, Dominique
A1  - Otillar, Robert
A1  - Salamov, Asaf
A1  - Schmutz, Jeremy
A1  - Shapiro, Harris
A1  - Lindquist, Erika
A1  - Lucas, Susan
A1  - Rokhsar, Daniel
A1  - Grigoriev, Igor V.
T1  - The selaginella genome identifies genetic changes associated with the evolution of vascular plants
JF  - Science
N2  - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1203810
SN  - 0036-8075
VL  - 332
IS  - 6032
SP  - 960
EP  - 963
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faiçal Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arrieta, M.
A1  - Aubert, Pierre
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Barnard, Michelle
A1  - Becherini, Yvonne
A1  - Tjus, Julia Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Bottcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Capasso, M.
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chevalier, J.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Condon, B.
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, Christoph
A1  - deWilt, P.
A1  - Djannati-Atai, Arache
A1  - Domainko, Wilfried
A1  - Donath, Axel
A1  - Dubus, Guillaume
A1  - Dutson, Kate
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, Stuart
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Funk, S.
A1  - Füßling, Matthias
A1  - Gabici, Stefano
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, Gianluca
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, Daniel
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, Daniela
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, Gilles
A1  - Hermann, G.
A1  - Hervet, Olivier
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, Alex
A1  - Jacholkowska, A.
A1  - Jamrozy, Marek
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, Felix
A1  - Jingo, M.
A1  - Jogler, Tobias
A1  - Jouvin, Lea
A1  - Jung-Richardt, Ira
A1  - Kastendieck, M. A.
A1  - Katarzynski, Krzysztof
A1  - Katz, Uli
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, Dmitry
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, Michael
A1  - Krayzel, F.
A1  - Kruger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, Jeanie
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, Thomas
A1  - Lorentz, M.
A1  - Lui, R.
A1  - Lypova, Iryna
A1  - Marandon, Vincent
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, Michael
A1  - Meintjes, Petrus Johannes
A1  - Menzler, U.
A1  - Meyer, Manuel
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, E.
A1  - Murach, T.
A1  - de Naurois, Mathieu
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, Hirokazu
A1  - Ohm, Stefan
A1  - Oettl, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, Marco
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, Helen
A1  - Prokhorov, Dmitry
A1  - Prokoph, Heike
A1  - Puehlhofer, Gerd
A1  - Punch, Michael
A1  - Quirrenbach, Andreas
A1  - Raab, S.
A1  - Reimer, Anita
A1  - Reimer, Olaf
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, Frank
A1  - Romoli, Carlo
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, David
A1  - Sanchez, David A.
A1  - Santangelo, Andrea
A1  - Sasaki, Manami
A1  - Schlickeiser, Reinhard
A1  - Schussler, F.
A1  - Schulz, Andreas
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, Felix
A1  - Spengler, G.
A1  - Spiess, F.
A1  - Stawarz, Lukasz
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, Martin
A1  - Trichard, C.
A1  - Tuffs, R.
A1  - van der Walt, Johan
A1  - van Eldik, Christopher
A1  - van Soelen, Brian
A1  - Vasileiadis, Georges
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, Jacco
A1  - Voisin, F.
A1  - Voelk, Heinrich J.
A1  - Vuillaume, Thomas
A1  - Wadiasingh, Z.
A1  - Wagner, Stefan J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, Alicja
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, Denis
A1  - Yang, R.
A1  - Zabalza, Victor
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Andreas
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywucka, Natalia
T1  - Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS
JF  - Physical review letters
N2  - The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevLett.117.111301
SN  - 0031-9007
SN  - 1079-7114
VL  - 117
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Kubas, Daniel
A1  - Cassan, A.
A1  - Beaulieu, Jean-Philippe
A1  - Coutures, C.
A1  - Dominik, M.
A1  - Albrow, Michael D.
A1  - Brillant, Stephane
A1  - Caldwell, John A. R.
A1  - Dominis, Dijana
A1  - Donatowicz, J.
A1  - Fendt, Christian
A1  - Fouque, P.
A1  - Jorgensen, Uffe Grae
A1  - Greenhill, John
A1  - Hill, K.
A1  - Heinmüller, Janine
A1  - Horne, Keith
A1  - Kane, Stephen R.
A1  - Marquette, Jean-Baptiste
A1  - Martin, Ralph
A1  - Menzies, J. W.
A1  - Pollard, K. R.
A1  - Sahu, K. C.
A1  - Vinter, C.
A1  - Wambsganss, Joachim
A1  - Watson, R.
A1  - Williams, A.
A1  - Thurl, C.
T1  - Full characterization of binary-lens event OGLE-2002-BLG-069 from PLANET observations
N2  - We analyze the photometric data obtained by PLANET and OGLE on the caustic-crossing binary-lens microlensing event OGLE-2002-BLG-069. Thanks to the excellent photometric and spectroscopic coverage of the event, we are able to constrain the lens model up to the known ambiguity between close and wide binary lenses. The detection of annual parallax in combination with measurements of extended-source effects allows us to determine the mass, distance and velocity of the lens components for the competing models. While the model involving a close binary lens leads to a Bulge- Disc lens scenario with a lens mass of M = (0.51 ± 0.15) M-&ODOT; and distance of D-L = (2.9 ± 0.4) kpc, the wide binary lens solution requires a rather implausible binary black-hole lens ( M &GSIM; 126 M-&ODOT;). Furthermore we compare current state-of-the-art numerical and empirical models for the surface brightness profile of the source, a G5III Bulge giant. We find that a linear limb-darkening model for the atmosphere of the source star is consistent with the data whereas a PHOENIX atmosphere model assuming LTE and with no free parameter does not match our observations
Y1  - 2005
SN  - 0004-6361
ER  - 
TY  - JOUR
A1  - Cassan, A.
A1  - Beaulieu, Jean-Philippe
A1  - Brillant, Stephane
A1  - Coutures, C.
A1  - Dominik, M.
A1  - Donatowicz, J.
A1  - Jorgensen, Uffe Grae
A1  - Kubas, Daniel
A1  - Albrow, Michael D.
A1  - Caldwell, John A. R.
A1  - Fouque, P.
A1  - Greenhill, John
A1  - Hill, K.
A1  - Horne, Keith
A1  - Kane, Stephen R.
A1  - Martin, Ralph
A1  - Menzies, J. W.
A1  - Pollard, K. R.
A1  - Sahu, K. C.
A1  - Vinter, C.
A1  - Wambsganss, Joachim
A1  - Watson, R.
A1  - Williams, A.
A1  - Fendt, Christian
A1  - Hauschildt, P.
A1  - Heinmueller, Janine
A1  - Marquette, Jean-Baptiste
A1  - Thurl, C.
T1  - Probing the atmosphere of the bulge G5III star OGLE-2002-BUL-069 by analysis of microlensed H alpha line
N2  - We discuss high-resolution, time-resolved spectra of the caustic exit of the binary microlensing event OGLE 2002-BLG-069 obtained with UVES on the VLT. The source star is a G5III giant in the Galactic Bulge. During such events, the source star is highly magnified, and a strong differential magnification around the caustic resolves its surface. Using an appropriate model stellar atmosphere generated by the PHOENIX v2.6 code we obtain a model light curve for the caustic exit and compare it with a dense set of photometric observations obtained by the PLANET microlensing follow up network. We further compare predicted variations in the Halpha equivalent width with those measured from our spectra. While the model and observations agree in the gross features, there are discrepancies suggesting shortcomings in the model, particularly for the Halpha line core, where we have detected amplified emission from the stellar chromosphere after the source star's trailing limb exited the caustic. This achievement became possible by the provision of the very efficient OGLE-III Early Warning System, a network of small telescopes capable of nearly-continuous round-the-clock photometric monitoring, on-line data reduction, daily near-real-time modelling in order to predict caustic crossing parameters, and a fast and efficient response of a 8 m class telescope to a "Target-of-Opportunity" observation request
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Jiang, G. F.
A1  - DePoy, D. L.
A1  - Gal-Yam, A.
A1  - Gaudi, B. S.
A1  - Gould, A.
A1  - Han, C.
A1  - Lipkin, Y.
A1  - Maoz, D.
A1  - Ofek, E. O.
A1  - Park, B. G.
A1  - Pogge, R. W.
A1  - Udalski, A.
A1  - Kubiak, Marcin
A1  - Szymanski, M. K.
A1  - Szewczyk, O.
A1  - Zerbrun, K.
A1  - Wyrzykowski, L.
A1  - Soszynski, I.
A1  - Pietrzynski, G.
A1  - Albrow, Michael D.
A1  - Beaulieu, Jean-Philippe
A1  - Caldwell, John A. R.
A1  - Cassan, A.
A1  - Coutures, C.
A1  - Dominik, M.
A1  - Donatowicz, J.
A1  - Fouque, P.
A1  - Greenhill, John
A1  - Hill, K.
A1  - Horne, Keith
A1  - Jorgensen, S. F.
A1  - Jorgensen, Uffe Grae
A1  - Kane, Stephen R.
A1  - Kubas, Daniel
A1  - Martin, Ralph
A1  - Menzies, J. W.
A1  - Pollard, R.
A1  - Sahu, K. C.
A1  - Wambsganss, Joachim
A1  - Watson, R.
A1  - Williams, A.
T1  - OGLE-2003-BLG-238 : Microlensing mass estimate of an isolated star
N2  - Microlensing is the only known direct method to measure the masses of stars that lack visible companions. In terms of microlensing observables, the mass is given by M (c(2)/4G)(r) over tilde (E)theta(E) and so requires the measurement of both the angular Einstein radius theta(E) and the projected Einstein radius (r) over tilde (E). Simultaneous measurement of these two parameters is extremely rare. Here we analyze OGLE-2003-BLG-238, a spectacularly bright (I-min 10.3), high-magnification (A(max) 170) microlensing event. Pronounced finite-source effects permit a measurement of theta(E) = 650 muas. Although the timescale of the event is only t(E) 38 days, one can still obtain weak constraints on the microlens parallax: 4.4 AU < <(r)over tilde>(E) < 18 AU at the 1 &sigma; level. Together these two parameter measurements yield a range for the lens mass of 0.36 M-&ODOT; < M < 1.48 M-&ODOT;. As was the case for MACHO- LMC-5, the only other single star (apart from the Sun) whose mass has been determined from its gravitational effects, this estimate is rather crude. It does, however, demonstrate the viability of the technique. We also discuss future prospects for single-lens mass measurements
Y1  - 2004
SN  - 0004-637X
ER  - 
TY  - JOUR
A1  - Sackett, Penny D.
A1  - Albrow, Michael D.
A1  - Beaulieu, Jean-Philippe
A1  - Caldwell, John A. R.
A1  - Coutures, C.
A1  - Dominik, M.
A1  - Greenhill, John
A1  - Hill, K.
A1  - Horne, Keith
A1  - Jorgensen, Uffe Grae
A1  - Kane, Stephen R.
A1  - Kubas, Daniel
A1  - Martin, Ralph
A1  - Menzies, J. W.
A1  - Pollard, K. R.
A1  - Sahu, K. C.
A1  - Wambsganß, Joachim
A1  - Watson, R.
A1  - Williams, A.
T1  - PLANET II : a microlensing and transit search for extrasolar planets
N2  - Due to their extremely small luminosity compared to the stars they orbit, planets outside our own Solar System are extraordinarily difficult to detect directly in optical light. Careful photometric monitoring of distant stars, however, can reveal the presence of exoplanets via the microlensing or eclipsing effects they induce. The international PLANET collaboration is performing such monitoring using a cadre of semi-dedicated telescopes around the world. Their results constrain the number of gas giants orbiting 1-7 AU from the most typical stars in the Galaxy. Upgrades in the program are opening regions of ''exoplanet discovery space'' - toward smaller masses and larger orbital radii - that are inaccessible to the Doppler velocity technique.
Y1  - 2003
UR  - http://arxiv.org/pdf/astro-ph/0211098
ER  - 
TY  - JOUR
A1  - Thomas, Jessica E.
A1  - Carvalho, Gary R.
A1  - Haile, James
A1  - Rawlence, Nicolas J.
A1  - Martin, Michael D.
A1  - Ho, Simon Y. W.
A1  - Sigfusson, Arnor P.
A1  - Josefsson, Vigfus A.
A1  - Frederiksen, Morten
A1  - Linnebjerg, Jannie F.
A1  - Castruita, Jose A. Samaniego
A1  - Niemann, Jonas
A1  - Sinding, Mikkel-Holger S.
A1  - Sandoval-Velasco, Marcela
A1  - Soares, Andre E. R.
A1  - Lacy, Robert
A1  - Barilaro, Christina
A1  - Best, Juila
A1  - Brandis, Dirk
A1  - Cavallo, Chiara
A1  - Elorza, Mikelo
A1  - Garrett, Kimball L.
A1  - Groot, Maaike
A1  - Johansson, Friederike
A1  - Lifjeld, Jan T.
A1  - Nilson, Goran
A1  - Serjeanston, Dale
A1  - Sweet, Paul
A1  - Fuller, Errol
A1  - Hufthammer, Anne Karin
A1  - Meldgaard, Morten
A1  - Fjeldsa, Jon
A1  - Shapiro, Beth
A1  - Hofreiter, Michael
A1  - Stewart, John R.
A1  - Gilbert, M. Thomas P.
A1  - Knapp, Michael
T1  - Demographic reconstruction from ancient DNA supports rapid extinction of the great auk
JF  - eLife
N2  - The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by integrating genetic data, GPS-based ocean current data, and analyses of population viability. We sequenced complete mitochondrial genomes of 41 individuals from across the species' geographic range and reconstructed population structure and population dynamics throughout the Holocene. Taken together, our data do not provide any evidence that great auks were at risk of extinction prior to the onset of intensive human hunting in the early 16th century. In addition, our population viability analyses reveal that even if the great auk had not been under threat by environmental change, human hunting alone could have been sufficient to cause its extinction. Our results emphasise the vulnerability of even abundant and widespread species to intense and localised exploitation.
Y1  - 2019
U6  - https://doi.org/10.7554/eLife.47509
SN  - 2050-084X
VL  - 8
PB  - eLife Sciences Publications
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Thomas, Jessica E.
A1  - Carvalho, Gary R.
A1  - Haile, James
A1  - Martin, Michael D.
A1  - Castruita, Jose A. Samaniego
A1  - Niemann, Jonas
A1  - Sinding, Mikkel-Holger S.
A1  - Sandoval-Velasco, Marcela
A1  - Rawlence, Nicolas J.
A1  - Fuller, Errol
A1  - Fjeldsa, Jon
A1  - Hofreiter, Michael
A1  - Stewart, John R.
A1  - Gilbert, M. Thomas P.
A1  - Knapp, Michael
T1  - An ‛Aukward’ tale
BT  - a genetic approach to discover the whereabouts of the  Last Great Auks
JF  - Genes
N2  - One hundred and seventy-three years ago, the last two Great Auks, Pinguinus impennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which—if any—of Fuller’s candidate skins likely belong to either of the two birds. Using mitochondrial genomes from the five candidate birds (housed in museums in Bremen, Brussels, Kiel, Los Angeles, and Oldenburg) and the organs of the last two known individuals, we partially solve the mystery that has been on Great Auk scholars’ minds for generations and make new suggestions as to the whereabouts of the still-missing skin from these two birds.
KW  - ancient DNA
KW  - extinct birds
KW  - mitochondrial genome
KW  - museum specimens
KW  - palaeogenomics
Y1  - 2017
U6  - https://doi.org/10.3390/genes8060164
SN  - 2073-4425
VL  - 8
IS  - 6
SP  - 164
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Beaumont, Robin N.
A1  - Warrington, Nicole M.
A1  - Cavadino, Alana
A1  - Tyrrell, Jessica
A1  - Nodzenski, Michael
A1  - Horikoshi, Momoko
A1  - Geller, Frank
A1  - Myhre, Ronny
A1  - Richmond, Rebecca C.
A1  - Paternoster, Lavinia
A1  - Bradfield, Jonathan P.
A1  - Kreiner-Moller, Eskil
A1  - Huikari, Ville
A1  - Metrustry, Sarah
A1  - Lunetta, Kathryn L.
A1  - Painter, Jodie N.
A1  - Hottenga, Jouke-Jan
A1  - Allard, Catherine
A1  - Barton, Sheila J.
A1  - Espinosa, Ana
A1  - Marsh, Julie A.
A1  - Potter, Catherine
A1  - Zhang, Ge
A1  - Ang, Wei
A1  - Berry, Diane J.
A1  - Bouchard, Luigi
A1  - Das, Shikta
A1  - Hakonarson, Hakon
A1  - Heikkinen, Jani
A1  - Helgeland, Oyvind
A1  - Hocher, Berthold
A1  - Hofman, Albert
A1  - Inskip, Hazel M.
A1  - Jones, Samuel E.
A1  - Kogevinas, Manolis
A1  - Lind, Penelope A.
A1  - Marullo, Letizia
A1  - Medland, Sarah E.
A1  - Murray, Anna
A1  - Murray, Jeffrey C.
A1  - Njolstad, Pal R.
A1  - Nohr, Ellen A.
A1  - Reichetzeder, Christoph
A1  - Ring, Susan M.
A1  - Ruth, Katherine S.
A1  - Santa-Marina, Loreto
A1  - Scholtens, Denise M.
A1  - Sebert, Sylvain
A1  - Sengpiel, Verena
A1  - Tuke, Marcus A.
A1  - Vaudel, Marc
A1  - Weedon, Michael N.
A1  - Willemsen, Gonneke
A1  - Wood, Andrew R.
A1  - Yaghootkar, Hanieh
A1  - Muglia, Louis J.
A1  - Bartels, Meike
A1  - Relton, Caroline L.
A1  - Pennell, Craig E.
A1  - Chatzi, Leda
A1  - Estivill, Xavier
A1  - Holloway, John W.
A1  - Boomsma, Dorret I.
A1  - Montgomery, Grant W.
A1  - Murabito, Joanne M.
A1  - Spector, Tim D.
A1  - Power, Christine
A1  - Jarvelin, Marjo-Ritta
A1  - Bisgaard, Hans
A1  - Grant, Struan F. A.
A1  - Sorensen, Thorkild I. A.
A1  - Jaddoe, Vincent W.
A1  - Jacobsson, Bo
A1  - Melbye, Mads
A1  - McCarthy, Mark I.
A1  - Hattersley, Andrew T.
A1  - Hayes, M. Geoffrey
A1  - Frayling, Timothy M.
A1  - Hivert, Marie-France
A1  - Felix, Janine F.
A1  - Hypponen, Elina
A1  - Lowe, William L.
A1  - Evans, David M.
A1  - Lawlor, Debbie A.
A1  - Feenstra, Bjarke
A1  - Freathy, Rachel M.
T1  - Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
JF  - Human molecular genetics
N2  - Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P< 5 x 10(-8). In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate that genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.
Y1  - 2018
U6  - https://doi.org/10.1093/hmg/ddx429
SN  - 0964-6906
SN  - 1460-2083
VL  - 27
IS  - 4
SP  - 742
EP  - 756
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - GEN
A1  - Kumar, Kevin K.
A1  - Goodwin, Cody R.
A1  - Uhouse, Michael A.
A1  - Bornhorst, Julia
A1  - Schwerdtle, Tanja
A1  - Aschner, Michael A.
A1  - McLean, John A.
A1  - Bowman, Aaron B.
T1  - Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status
N2  - Manganese (Mn) is an essential micronutrient for development and function of the nervous system. Deficiencies in Mn transport have been implicated in the pathogenesis of Huntington's disease (HD), an autosomal dominant neurodegenerative disorder characterized by loss of medium spiny neurons of the striatum. Brain Mn levels are highest in striatum and other basal ganglia structures, the most sensitive brain regions to Mn neurotoxicity. Mouse models of HD exhibit decreased striatal Mn accumulation and HD striatal neuron models are resistant to Mn cytotoxicity. We hypothesized that the observed modulation of Mn cellular transport is associated with compensatory metabolic responses to HD pathology. Here we use an untargeted metabolomics approach by performing ultraperformance liquid chromatography-ion mobility-mass spectrometry (UPLC-IM-MS) on control and HD immortalized mouse striatal neurons to identify metabolic disruptions under three Mn exposure conditions, low (vehicle), moderate (non-cytotoxic) and high (cytotoxic). Our analysis revealed lower metabolite levels of pantothenic acid, and glutathione (GSH) in HD striatal cells relative to control cells. HD striatal cells also exhibited lower abundance and impaired induction of isobutyryl carnitine in response to increasing Mn exposure. In addition, we observed induction of metabolites in the pentose shunt pathway in HD striatal cells after high Mn exposure. These findings provide metabolic evidence of an interaction between the HD genotype and biologically relevant levels of Mn in a striatal cell model with known HD by Mn exposure interactions. The metabolic phenotypes detected support existing hypotheses that changes in energetic processes underlie the pathobiology of both HD and Mn neurotoxicity.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 232 
KW  - cells
KW  - coenzyme-a
KW  - database
KW  - energy-metabolism
KW  - glutathione
KW  - hallervorden-spatz-syndrome
KW  - mobility-mass spectrometry
KW  - model
KW  - neurodegeneration
KW  - neurotoxicity
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-94314
SP  - 363
EP  - 370
ER  - 
TY  - JOUR
A1  - Hetenyi, Gyorgy
A1  - Molinari, Irene
A1  - Clinton, John
A1  - Bokelmann, Gotz
A1  - Bondar, Istvan
A1  - Crawford, Wayne C.
A1  - Dessa, Jean-Xavier
A1  - Doubre, Cecile
A1  - Friederich, Wolfgang
A1  - Fuchs, Florian
A1  - Giardini, Domenico
A1  - Graczer, Zoltan
A1  - Handy, Mark R.
A1  - Herak, Marijan
A1  - Jia, Yan
A1  - Kissling, Edi
A1  - Kopp, Heidrun
A1  - Korn, Michael
A1  - Margheriti, Lucia
A1  - Meier, Thomas
A1  - Mucciarelli, Marco
A1  - Paul, Anne
A1  - Pesaresi, Damiano
A1  - Piromallo, Claudia
A1  - Plenefisch, Thomas
A1  - Plomerova, Jaroslava
A1  - Ritter, Joachim
A1  - Rumpker, Georg
A1  - Sipka, Vesna
A1  - Spallarossa, Daniele
A1  - Thomas, Christine
A1  - Tilmann, Frederik
A1  - Wassermann, Joachim
A1  - Weber, Michael
A1  - Weber, Zoltan
A1  - Wesztergom, Viktor
A1  - Zivcic, Mladen
A1  - Abreu, Rafael
A1  - Allegretti, Ivo
A1  - Apoloner, Maria-Theresia
A1  - Aubert, Coralie
A1  - Besancon, Simon
A1  - de Berc, Maxime Bes
A1  - Brunel, Didier
A1  - Capello, Marco
A1  - Carman, Martina
A1  - Cavaliere, Adriano
A1  - Cheze, Jerome
A1  - Chiarabba, Claudio
A1  - Cougoulat, Glenn
A1  - Cristiano, Luigia
A1  - Czifra, Tibor
A1  - Danesi, Stefania
A1  - Daniel, Romuald
A1  - Dannowski, Anke
A1  - Dasovic, Iva
A1  - Deschamps, Anne
A1  - Egdorf, Sven
A1  - Fiket, Tomislav
A1  - Fischer, Kasper
A1  - Funke, Sigward
A1  - Govoni, Aladino
A1  - Groschl, Gidera
A1  - Heimers, Stefan
A1  - Heit, Ben
A1  - Herak, Davorka
A1  - Huber, Johann
A1  - Jaric, Dejan
A1  - Jedlicka, Petr
A1  - Jund, Helene
A1  - Klingen, Stefan
A1  - Klotz, Bernhard
A1  - Kolinsky, Petr
A1  - Kotek, Josef
A1  - Kuhne, Lothar
A1  - Kuk, Kreso
A1  - Lange, Dietrich
A1  - Loos, Jurgen
A1  - Lovati, Sara
A1  - Malengros, Deny
A1  - Maron, Christophe
A1  - Martin, Xavier
A1  - Massa, Marco
A1  - Mazzarini, Francesco
A1  - Metral, Laurent
A1  - Moretti, Milena
A1  - Munzarova, Helena
A1  - Nardi, Anna
A1  - Pahor, Jurij
A1  - Pequegnat, Catherine
A1  - Petersen, Florian
A1  - Piccinini, Davide
A1  - Pondrelli, Silvia
A1  - Prevolnik, Snjezan
A1  - Racine, Roman
A1  - Regnier, Marc
A1  - Reiss, Miriam
A1  - Salimbeni, Simone
A1  - Santulin, Marco
A1  - Scherer, Werner
A1  - Schippkus, Sven
A1  - Schulte-Kortnack, Detlef
A1  - Solarino, Stefano
A1  - Spieker, Kathrin
A1  - Stipcevic, Josip
A1  - Strollo, Angelo
A1  - Sule, Balint
A1  - Szanyi, Gyongyver
A1  - Szucs, Eszter
A1  - Thorwart, Martin
A1  - Ueding, Stefan
A1  - Vallocchia, Massimiliano
A1  - Vecsey, Ludek
A1  - Voigt, Rene
A1  - Weidle, Christian
A1  - Weyland, Gauthier
A1  - Wiemer, Stefan
A1  - Wolf, Felix
A1  - Wolyniec, David
A1  - Zieke, Thomas
T1  - The AlpArray seismic network
BT  - a large-scale european experiment to image the alpine orogen
JF  - Surveys in Geophysics
N2  - The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.
KW  - Seismology
KW  - Alps
KW  - Seismic network
KW  - Geodynamics
KW  - Seismic imaging
KW  - Mountain building
Y1  - 2018
U6  - https://doi.org/10.1007/s10712-018-9472-4
SN  - 0169-3298
SN  - 1573-0956
VL  - 39
IS  - 5
SP  - 1009
EP  - 1033
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - CHAP
A1  - Tidball, Andrew M.
A1  - Kumar, Kevin K.
A1  - Bryan, Miles R.
A1  - Bichell, Terry Jo
A1  - Horning, Kyle
A1  - Uhouse, Michael A.
A1  - Goodwin, Cody R.
A1  - Bornhorst, Julia
A1  - Schwerdtle, Tanja
A1  - Neely, Maja Diana
A1  - McClean, John A.
A1  - Aschner, Michael A.
A1  - Bowman, Aaron B.
T1  - Deficits in neural responses to manganese exposure in Huntington's disease models
T2  - Neurotoxicology and teratology
Y1  - 2015
U6  - https://doi.org/10.1016/j.ntt.2015.04.022
SN  - 0892-0362
SN  - 1872-9738
VL  - 49
SP  - 105
EP  - 105
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - King, Turi E.
A1  - Gonzalez-Fortes, Gloria M.
A1  - Balaresque, Patricia
A1  - Thomas, Mark G.
A1  - Balding, David
A1  - Delser, Pierpaolo Maisano
A1  - Neumann, Rita
A1  - Parson, Walther
A1  - Knapp, Michael
A1  - Walsh, Susan
A1  - Tonasso, Laure
A1  - Holt, John
A1  - Kayser, Manfred
A1  - Appleby, Jo
A1  - Forster, Peter
A1  - Ekserdjian, David
A1  - Hofreiter, Michael
A1  - Schuerer, Kevin
T1  - Identification of the remains of King Richard III
JF  - Nature Communications
Y1  - 2014
U6  - https://doi.org/10.1038/ncomms6631
SN  - 2041-1723
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Kumar, Kevin K.
A1  - Goodwin, Cody R.
A1  - Uhouse, Michael A.
A1  - Bornhorst, Julia
A1  - Schwerdtle, Tanja
A1  - Aschner, Michael A.
A1  - McLean, John A.
A1  - Bowman, Aaron B.
T1  - Untargeted metabolic profiling identifies interactions between
JF  - Metallomics : integrated biometal science
Y1  - 2015
U6  - https://doi.org/10.1039/c4mt00223g
SN  - 1756-5901
SN  - 1756-591X
VL  - 7
IS  - 2
SP  - 363
EP  - 370
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Beaumont, Robin N.
A1  - Warrington, Nicole M.
A1  - Cavadino, Alana
A1  - Tyrrell, Jessica
A1  - Nodzenski, Michael
A1  - Horikoshi, Momoko
A1  - Geller, Frank
A1  - Myhre, Ronny
A1  - Richmond, Rebecca C.
A1  - Paternoster, Lavinia
A1  - Bradfield, Jonathan P.
A1  - Kreiner-Møller, Eskil
A1  - Huikari, Ville
A1  - Metrustry, Sarah
A1  - Lunetta, Kathryn L.
A1  - Painter, Jodie N.
A1  - Hottenga, Jouke-Jan
A1  - Allard, Catherine
A1  - Barton, Sheila J.
A1  - Espinosa, Ana
A1  - Marsh, Julie A.
A1  - Potter, Catherine
A1  - Zhang, Ge
A1  - Ang, Wei
A1  - Berry, Diane J.
A1  - Bouchard, Luigi
A1  - Das, Shikta
A1  - Hakonarson, Hakon
A1  - Heikkinen, Jani
A1  - Helgeland, Øyvind
A1  - Hocher, Berthold
A1  - Hofman, Albert
A1  - Inskip, Hazel M.
A1  - Jones, Samuel E.
A1  - Kogevinas, Manolis
A1  - Lind, Penelope A.
A1  - Marullo, Letizia
A1  - Medland, Sarah E.
A1  - Murray, Anna
A1  - Murray, Jeffrey C.
A1  - Njølstad, Pa ̊l R.
A1  - Nohr, Ellen A.
A1  - Reichetzeder, Christoph
A1  - Ring, Susan M.
A1  - Ruth, Katherine S.
A1  - Santa-Marina, Loreto
A1  - Scholtens, Denise M.
A1  - Sebert, Sylvain
A1  - Sengpiel, Verena
A1  - Tuke, Marcus A.
A1  - Vaudel, Marc
A1  - Weedon, Michael N.
A1  - Willemsen, Gonneke
A1  - Wood, Andrew R.
A1  - Yaghootkar, Hanieh
A1  - Muglia, Louis J.
A1  - Bartels, Meike
A1  - Relton, Caroline L.
A1  - Pennell, Craig E.
A1  - Chatzi, Leda
A1  - Estivill, Xavier
A1  - Holloway, John W.
A1  - Boomsma, Dorret I.
A1  - Montgomery, Grant W.
A1  - Murabito, Joanne M.
A1  - Spector, Tim D.
A1  - Power, Christine
A1  - Ja ̈rvelin, Marjo-Ritta
A1  - Bisgaard, Hans
A1  - Grant, Struan F.A.
A1  - Sørensen, Thorkild I.A.
A1  - Jaddoe, Vincent W.
A1  - Jacobsson, Bo
A1  - Melbye, Mads
A1  - McCarthy, Mark I.
A1  - Hattersley, Andrew T.
A1  - Hayes, M. Geoffrey
A1  - Frayling, Timothy M.
A1  - Hivert, Marie-France
A1  - Felix, Janine F.
A1  - Hyppo ̈nen, Elina
A1  - Lowe, William L. , Jr
A1  - Evans, David M.
A1  - Lawlor, Debbie A.
A1  - Feenstra, Bjarke
A1  - Freathy, Rachel M.
T1  - Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother–child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P < 5 Â 10 À8 . In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate that genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 628 
KW  - alleles
KW  - birth weight
KW  - fetus
KW  - genotype
KW  - mothers
KW  - single nucleotide polymorphism
KW  - genetics
KW  - duration of gestation
KW  - genome-wide association study
KW  - offspring
KW  - biobanks
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-423100
SN  - 1866-8372
IS  - 628
ER  - 
TY  - JOUR
A1  - Kumar, Kevin K.
A1  - Goodwin, Cody R.
A1  - Uhouse, Michael A.
A1  - Bornhorst, Julia
A1  - Schwerdtle, Tanja
A1  - Aschner, Michael A.
A1  - McLean, John A.
A1  - Bowman, Aaron B.
T1  - Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status
JF  - Metallomics
N2  - Manganese (Mn) is an essential micronutrient for development and function of the nervous system. Deficiencies in Mn transport have been implicated in the pathogenesis of Huntington's disease (HD), an autosomal dominant neurodegenerative disorder characterized by loss of medium spiny neurons of the striatum. Brain Mn levels are highest in striatum and other basal ganglia structures, the most sensitive brain regions to Mn neurotoxicity. Mouse models of HD exhibit decreased striatal Mn accumulation and HD striatal neuron models are resistant to Mn cytotoxicity. We hypothesized that the observed modulation of Mn cellular transport is associated with compensatory metabolic responses to HD pathology. Here we use an untargeted metabolomics approach by performing ultraperformance liquid chromatography-ion mobility-mass spectrometry (UPLC-IM-MS) on control and HD immortalized mouse striatal neurons to identify metabolic disruptions under three Mn exposure conditions, low (vehicle), moderate (non-cytotoxic) and high (cytotoxic). Our analysis revealed lower metabolite levels of pantothenic acid, and glutathione (GSH) in HD striatal cells relative to control cells. HD striatal cells also exhibited lower abundance and impaired induction of isobutyryl carnitine in response to increasing Mn exposure. In addition, we observed induction of metabolites in the pentose shunt pathway in HD striatal cells after high Mn exposure. These findings provide metabolic evidence of an interaction between the HD genotype and biologically relevant levels of Mn in a striatal cell model with known HD by Mn exposure interactions. The metabolic phenotypes detected support existing hypotheses that changes in energetic processes underlie the pathobiology of both HD and Mn neurotoxicity.
KW  - hallervorden-spatz-syndrome
KW  - mobility-mass spectrometry
KW  - energy-metabolism
KW  - coenzyme-a
KW  - model
KW  - neurotoxicity
KW  - glutathione
KW  - database
KW  - cells
KW  - neurodegeneration
Y1  - 2015
U6  - https://doi.org/10.1039/C4MT00223G
SN  - 1756-591X
SN  - 1756-5901
VL  - 7
SP  - 363
EP  - 370
PB  - RSC Publ.
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Paijmans, Johanna L. A.
A1  - Barnett, Ross
A1  - Gilbert, M. Thomas P.
A1  - Zepeda-Mendoza, M. Lisandra
A1  - Reumer, Jelle W. F.
A1  - de Vos, John
A1  - Zazula, Grant
A1  - Nagel, Doris
A1  - Baryshnikov, Gennady F.
A1  - Leonard, Jennifer A.
A1  - Rohland, Nadin
A1  - Westbury, Michael V.
A1  - Barlow, Axel
A1  - Hofreiter, Michael
T1  - Evolutionary History of Saber-Toothed Cats Based on Ancient Mitogenomics
JF  - Current biology
N2  - Saber-toothed cats (Machairodontinae) are among the most widely recognized representatives of the now largely extinct Pleistocene megafauna. However, many aspects of their ecology, evolution, and extinction remain uncertain. Although ancient-DNA studies have led to huge advances in our knowledge of these aspects of many other megafauna species (e.g., mammoths and cave bears), relatively few ancient-DNA studies have focused on saber-toothed cats [1-3], and they have been restricted to short fragments of mitochondrial DNA. Here we investigate the evolutionary history of two lineages of saber-toothed cats (Smilodon and Homotherium) in relation to living carnivores and find that the Machairodontinae form a well-supported clade that is distinct from all living felids. We present partial mitochondrial genomes from one S. populator sample and three Homotherium sp. samples, including the only Late Pleistocene Homotherium sample from Eurasia [4]. We confirm the identification of the unique Late Pleistocene European fossil through ancient-DNA analyses, thus strengthening the evidence that Homotherium occurred in Europe over 200,000 years later than previously believed. This in turn forces a re-evaluation of its demography and extinction dynamics. Within the Machairodontinae, we find a deep divergence between Smilodon and Homotherium (similar to 18 million years) but limited diversity between the American and European Homotherium specimens. The genetic data support the hypothesis that all Late Pleistocene (or post-Villafrancian) Homotherium should be considered a single species, H. latidens, which was previously proposed based on morphological data [5, 6].
Y1  - 2017
U6  - https://doi.org/10.1016/j.cub.2017.09.033
SN  - 0960-9822
SN  - 1879-0445
VL  - 27
SP  - 3330
EP  - +
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Ran, Niva A.
A1  - Love, John A.
A1  - Heiber, Michael C.
A1  - Jiao, Xuechen
A1  - Hughes, Michael P.
A1  - Karki, Akchheta
A1  - Wang, Ming
A1  - Brus, Viktor V.
A1  - Wang, Hengbin
A1  - Neher, Dieter
A1  - Ade, Harald
A1  - Bazan, Guillermo C.
A1  - Thuc-Quyen Nguyen, 
T1  - Charge generation and recombination in an organic solar cell with low energetic offsets
JF  - dvanced energy materials
N2  - Organic bulk heterojunction (BHJ) solar cells require energetic offsets between the donor and acceptor to obtain high short-circuit currents (J(SC)) and fill factors (FF). However, it is necessary to reduce the energetic offsets to achieve high open-circuit voltages (V-OC). Recently, reports have highlighted BHJ blends that are pushing at the accepted limits of energetic offsets necessary for high efficiency. Unfortunately, most of these BHJs have modest FF values. How the energetic offset impacts the solar cell characteristics thus remains poorly understood. Here, a comprehensive characterization of the losses in a polymer:fullerene BHJ blend, PIPCP:phenyl-C61-butyric acid methyl ester (PC61BM), that achieves a high V-OC (0.9 V) with very low energy losses (E-loss = 0.52 eV) from the energy of absorbed photons, a respectable J(SC) (13 mA cm(-2)), but a limited FF (54%) is reported. Despite the low energetic offset, the system does not suffer from field-dependent generation and instead it is characterized by very fast nongeminate recombination and the presence of shallow traps. The charge-carrier losses are attributed to suboptimal morphology due to high miscibility between PIPCP and PC61BM. These results hold promise that given the appropriate morphology, the J(SC), V-OC, and FF can all be improved, even with very low energetic offsets.
KW  - energetic offset
KW  - fill factor
KW  - morphology
KW  - organic solar cells
KW  - recombination
Y1  - 2018
U6  - https://doi.org/10.1002/aenm.201701073
SN  - 1614-6832
SN  - 1614-6840
VL  - 8
IS  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Andersson, T.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arrieta, M.
A1  - Aubert, Pierre
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Barnard, Michelle
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Boettcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Capasso, M.
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chevalier, J.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Condon, B.
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, C.
A1  - Devin, J.
A1  - de Wilt, P.
A1  - Djannati-Ataie, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Funk, S.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, D.
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jingo, M.
A1  - Jogler, T.
A1  - Jouvin, L.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, M.
A1  - Krayzel, F.
A1  - Krueger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Liu, R.
A1  - Lohse, T.
A1  - Lorentz, M.
A1  - Lypova, I.
A1  - Marandon, V.
A1  - Marcowith, A.
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, Michael
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, E.
A1  - Murach, T.
A1  - de Naurois, M.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Ostrowski, M.
A1  - Oettl, S.
A1  - Oya, I.
A1  - Padovani, M.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Perennes, C.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, H.
A1  - Prokhorov, D.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Reyes, R. de los
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, A.
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schuessler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Settimo, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shilon, I.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tibaldo, L.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tuffs, R.
A1  - van der Walt, J.
A1  - van Eldik, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywucka, N.
T1  - HESS Limits on Linelike Dark Matter Signatures in the 100 GeV to 2 TeV Energy Range Close to the Galactic Center
JF  - Physical review letters
N2  - A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l = -1.5 degrees, b = 0 degrees and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S. results. No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevLett.117.151302
SN  - 0031-9007
SN  - 1079-7114
VL  - 117
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - CHAP
A1  - Trilcke, Peer
A1  - Parr, Rolf
A1  - D'Aprile, Iwan-Michelangelo
A1  - Kraus, Hans-Christof
A1  - Blomqvist, Clarissa
A1  - McGillen, Petra S.
A1  - Aus der Au, Carmen
A1  - Phillips, Alexander Robert
A1  - Helmer, Debora
A1  - Singer, Rüdiger
A1  - Görner, Rüdiger
A1  - Berbig, Roland
A1  - Rose, Dirk
A1  - Wilhelms, Kerstin
A1  - Krause, Marcus
A1  - Hehle, Christine
A1  - Gretz, Daniela
A1  - Gfrereis, Heike
A1  - Lepp, Nicola
A1  - Morlok, Franziska
A1  - Haut, Gideon
A1  - Brechenmacher, Thomas
A1  - Stauffer, Isabelle
A1  - Lyon, John B.
A1  - Bachmann, Vera
A1  - Ewert, Michael
A1  - Immer, Nikolas
A1  - Vedder, Ulrike
A1  - Fischer, Hubertus
A1  - Becker, Sabina
A1  - Wegmann, Christoph
A1  - Möller, Klaus-Peter
A1  - Schneider, Ulrike
A1  - Waszynski, Alexander
A1  - Wedel, Michael
A1  - Brehm, David
A1  - Wolpert, Georg
ED  - Trilcke, Peer
T1  - Fontanes Medien
N2  - Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen.
Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar.
KW  - Fontane, Theodor
KW  - Gesellschaft
KW  - Medialisierung
KW  - Presse
Y1  - 2022
SN  - 978-3-11-073330-3
SN  - 978-3-11-073810-0
SN  - 978-3-11-073323-5
U6  - https://doi.org/10.1515/9783110733235
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - GEN
A1  - Trilcke, Peer
A1  - Parr, Rolf
A1  - D'Aprile, Iwan-Michelangelo
A1  - Kraus, Hans-Christof
A1  - Blomqvist, Clarissa
A1  - McGillen, Petra S.
A1  - Aus der Au, Carmen
A1  - Phillips, Alexander Robert
A1  - Helmer, Debora
A1  - Singer, Rüdiger
A1  - Görner, Rüdiger
A1  - Berbig, Roland
A1  - Rose, Dirk
A1  - Wilhelms, Kerstin
A1  - Krause, Marcus
A1  - Hehle, Christine
A1  - Gretz, Daniela
A1  - Gfrereis, Heike
A1  - Lepp, Nicola
A1  - Morlok, Franziska
A1  - Haut, Gideon
A1  - Brechenmacher, Thomas
A1  - Stauffer, Isabelle
A1  - Lyon, John B.
A1  - Bachmann, Vera
A1  - Ewert, Michael
A1  - Immer, Nikolas
A1  - Vedder, Ulrike
A1  - Fischer, Hubertus
A1  - Becker, Sabina
A1  - Wegmann, Christoph
A1  - Möller, Klaus-Peter
A1  - Schneider, Ulrike
A1  - Waszynski, Alexander
A1  - Wedel, Michael
A1  - Brehm, David
A1  - Wolpert, Georg
ED  - Trilcke, Peer
T1  - Fontanes Medien
T2  - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe
N2  - Theodor Fontane war, im durchaus modernen Sinne, ein Medienarbeiter: Als Presse-Agent in London lernte er die innovativste Presselandschaft seiner Zeit kennen; als Redakteur in Berlin leistete er journalistische Kärrnerarbeit; er schrieb Kritiken über das Theater, die bildende Kunst und die Literatur – und auch seine Romane wie seine Reisebücher sind stets Medienprodukte, als Serien in in Zeitungen und Zeitschriften platziert, bevor sie auf dem Buchmarkt erschienen.
Der vorliegende Band dokumentiert die Ergebnisse eines internationalen Kongresses, veranstaltet 2019 vom Theodor-Fontane-Archiv in Potsdam. Die ebenso rasante wie umfassende Medialisierung und Vernetzung der Gesellschaft im Laufe des 19. Jahrhunderts wird dabei als produktive Voraussetzung der schriftstellerischen Tätigkeit Fontanes begriffen. Eingebettet in ein weit verzweigtes Netz der Korrespondenz und der postalischen Textzirkulation, vertraut mit den Routinen und Publika der periodischen Massenpresse, für die er sein Leben lang schrieb, und auf vielfältige Weise geprägt von der visuellen Kultur seiner Zeit wird Theodor Fontane als gleichermaßen journalistisch versierter wie ästhetisch sensibler Grenzgänger erkennbar.
T3  - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 178 
KW  - Fontane, Theodor
KW  - Gesellschaft
KW  - Medialisierung
KW  - Presse
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-574079
SN  - 1866-8380
IS  - 178
ER  - 
TY  - JOUR
A1  - Eichler, Sarah
A1  - Rabe, Sophie
A1  - Salzwedel, Annett
A1  - Mueller, Steffen
A1  - Stoll, Josefine
A1  - Tilgner, Nina
A1  - John, Michael
A1  - Wegscheider, Karl
A1  - Mayer, Frank
A1  - Völler, Heinz
T1  - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement: study protocol for a multicenter, superiority, no-blinded randomized controlled trial
JF  - Trials
N2  - Background: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain. Methods/design: This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints. Discussion: We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas.
KW  - Telerehabilitation
KW  - Home-based
KW  - Total hip replacement
KW  - Total knee replacement
KW  - Exercise therapy
KW  - Aftercare
Y1  - 2017
U6  - https://doi.org/10.1186/s13063-017-2173-3
SN  - 1745-6215
VL  - 18
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Wochatz, Monique
A1  - Tilgner, Nina
A1  - Mueller, Steffen
A1  - Rabe, Sophie
A1  - Eichler, Sarah
A1  - John, Michael
A1  - Völler, Heinz
A1  - Mayer, Frank
T1  - Reliability and validity of the Kinect V2 for the assessment of lower extremity rehabilitation exercises
JF  - Gait & posture
N2  - Research question: The purpose of this study was to evaluate the test-retest reliability of lower extremity kinematics during squat, hip abduction and lunge exercises captured by the Kinect and to evaluate the agreement to a reference 3D camera-based motion system. Methods: Twenty-one healthy individuals performed five repetitions of each lower limb exercise on two different days. Movements were simultaneously assessed by the Kinect and the reference 3D motion system. Joint angles and positions of the lower limb were calculated for sagittal and frontal plane. For the inter-session reliability and the agreement between the two systems standard error of measurement (SEM), bias with limits of agreement (LoA) and Pearson Correlation Coefficient (r) were calculated. Results: Parameters indicated varying reliability for the assessed joint angles and positions and decreasing reliability with increasing task complexity. Across all exercises, measurement deviations were shown especially for small movement amplitudes. Variability was acceptable for joint angles and positions during the squat, partially acceptable during the hip abduction and predominately inacceptable during the lunge. The agreement between systems was characterized by systematic errors. Overestimations by the Kinect were apparent for hip flexion during the squat and hip abduction/adduction during the hip abduction exercise as well as for the knee positions during the lunge. Knee and hip flexion during hip abduction and lunge were underestimated by the Kinect. Significance: The Kinect system can reliably assess lower limb joint angles and positions during simple exercises. The validity of the system is however restricted. An application in the field of early orthopedic rehabilitation without further development of post-processing techniques seems so far limited.
KW  - Reproducibility
KW  - Agreement
KW  - Markerless motion capture system
KW  - Telerehabilitation
Y1  - 2018
U6  - https://doi.org/10.1016/j.gaitpost.2019.03.020
SN  - 0966-6362
SN  - 1879-2219
VL  - 70
SP  - 330
EP  - 335
PB  - Elsevier
CY  - Clare
ER  - 
TY  - INPR
A1  - Walz, Norbert
A1  - Adrian, Rita
A1  - Gilbert, John J.
A1  - Monaghan, Michael T.
A1  - Weithoff, Guntram
A1  - Zimmermann-Timm, Heike
T1  - Preface
T2  - Hydrobiologia : acta hydrobiologica, hydrographica, limnologica et protistologica
Y1  - 2011
U6  - https://doi.org/10.1007/s10750-010-0514-2
SN  - 0018-8158
VL  - 662
IS  - 1
SP  - 1
EP  - 4
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Induli, Martha
A1  - Cheloti, Michael
A1  - Wasuna, Antonina
A1  - Wekesa, Ingrid
A1  - Wanjohi, John M.
A1  - Byamukama, Robert
A1  - Heydenrich, Matthias
A1  - Makayoto, Moses
A1  - Yenesew, Abiy
T1  - Naphthoquinones from the roots of Aloe secundiflora
JF  - Phytochemistry letters
N2  - Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21-23 mu g/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mu g/mL).
KW  - Aloe secundiflora
KW  - Asphodelaceae
KW  - Roots
KW  - Naphthoquinone
KW  - 5-Hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione 5,8-Dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione
KW  - Anthraquinone
KW  - Aloesaponarin I
KW  - Mycobacterium tuberculosis
Y1  - 2012
U6  - https://doi.org/10.1016/j.phytol.2012.04.014
SN  - 1874-3900
VL  - 5
IS  - 3
SP  - 506
EP  - 509
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Eichler, Sarah
A1  - Salzwedel, Annett
A1  - Rabe, Sophie
A1  - Mueller, Steffen
A1  - Mayer, Frank
A1  - Wochatz, Monique
A1  - Hadzic, Miralem
A1  - John, Michael
A1  - Wegscheider, Karl
A1  - Völler, Heinz
T1  - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement
BT  - Randomized Controlled Trial
JF  - JMIR Rehabilitation and Assistive Technologies
N2  - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare.

Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare.

Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints.

Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note.

Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare.
KW  - telerehabilitation
KW  - home-based
KW  - total hip replacement
KW  - total knee replacement
KW  - exercise therapy
KW  - aftercare
KW  - rehabilitation
Y1  - 2019
U6  - https://doi.org/10.2196/14236
SN  - 2369-2529
VL  - 6
IS  - 2
PB  - jmir rehab
CY  - Toronto
ER  - 
TY  - GEN
A1  - Dommain, René
A1  - Andama, Morgan
A1  - McDonough, Molly M.
A1  - Prado, Natalia A.
A1  - Goldhammer, Tobias
A1  - Potts, Richard
A1  - Maldonado, Jesús E.
A1  - Nkurunungi, John Bosco
A1  - Campana, Michael G.
T1  - The Challenges of Reconstructing Tropical Biodiversity With Sedimentary Ancient DNA
BT  - A 2200-Year-Long Metagenomic Record From Bwindi Impenetrable Forest, Uganda
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Sedimentary ancient DNA has been proposed as a key methodology for reconstructing biodiversity over time. Yet, despite the concentration of Earth’s biodiversity in the tropics, this method has rarely been applied in this region. Moreover, the taphonomy of sedimentary DNA, especially in tropical environments, is poorly understood. This study elucidates challenges and opportunities of sedimentary ancient DNA approaches for reconstructing tropical biodiversity. We present shotgun-sequenced metagenomic profiles and DNA degradation patterns from multiple sediment cores from Mubwindi Swamp, located in Bwindi Impenetrable Forest (Uganda), one of the most diverse forests in Africa. We describe the taxonomic composition of the sediments covering the past 2200 years and compare the sedimentary DNA data with a comprehensive set of environmental and sedimentological parameters to unravel the conditions of DNA degradation. Consistent with the preservation of authentic ancient DNA in tropical swamp sediments, DNA concentration and mean fragment length declined exponentially with age and depth, while terminal deamination increased with age. DNA preservation patterns cannot be explained by any environmental parameter alone, but age seems to be the primary driver of DNA degradation in the swamp. Besides degradation, the presence of living microbial communities in the sediment also affects DNA quantity. Critically, 92.3% of our metagenomic data of a total 81.8 million unique, merged reads cannot be taxonomically identified due to the absence of genomic references in public databases. Of the remaining 7.7%, most of the data (93.0%) derive from Bacteria and Archaea, whereas only 0–5.8% are from Metazoa and 0–6.9% from Viridiplantae, in part due to unbalanced taxa representation in the reference data. The plant DNA record at ordinal level agrees well with local pollen data but resolves less diversity. Our animal DNA record reveals the presence of 41 native taxa (16 orders) including Afrotheria, Carnivora, and Ruminantia at Bwindi during the past 2200 years. Overall, we observe no decline in taxonomic richness with increasing age suggesting that several-thousand-year-old information on past biodiversity can be retrieved from tropical sediments. However, comprehensive genomic surveys of tropical biota need prioritization for sedimentary DNA to be a viable methodology for future tropical biodiversity studies.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 970 
KW  - sedimentary ancient DNA
KW  - tropical biodiversity
KW  - DNA preservation
KW  - sediment
KW  - tropical swamp
KW  - shotgun sequencing
KW  - metagenomic analysis
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-474305
SN  - 1866-8372
IS  - 970
ER  - 
TY  - GEN
A1  - López de Guereñu, Anna
A1  - Bastian, Philipp
A1  - Wessig, Pablo
A1  - John, Leonard
A1  - Kumke, Michael Uwe
T1  - Energy transfer between tm-doped upconverting nanoparticles and a small organic dye with large stokes shift
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - Lanthanide-doped upconverting nanoparticles (UCNP) are being extensively studied for bioapplications due to their unique photoluminescence properties and low toxicity. Interest in RET applications involving UCNP is also increasing, but due to factors such as large sizes, ion emission distributions within the particles, and complicated energy transfer processes within the UCNP, there are still many questions to be answered. In this study, four types of core and core-shell NaYF4-based UCNP co-doped with Yb3+ and Tm3+ as sensitizer and activator, respectively, were investigated as donors for the Methyl 5-(8-decanoylbenzo[1,2-d:4,5-d ']bis([1,3]dioxole)-4-yl)-5-oxopentanoate (DBD-6) dye. The possibility of resonance energy transfer (RET) between UCNP and the DBD-6 attached to their surface was demonstrated based on the comparison of luminescence intensities, band ratios, and decay kinetics. The architecture of UCNP influenced both the luminescence properties and the energy transfer to the dye: UCNP with an inert shell were the brightest, but their RET efficiency was the lowest (17%). Nanoparticles with Tm3+ only in the shell have revealed the highest RET efficiencies (up to 51%) despite the compromised luminescence due to surface quenching.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 961 
KW  - resonance energy transfer
KW  - DBD dye
KW  - core shell UCNP
KW  - time-resolved luminescence
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-472240
SN  - 1866-8372
IS  - 961
ER  - 
TY  - GEN
A1  - Eichler, Sarah
A1  - Salzwedel, Annett
A1  - Rabe, Sophie
A1  - Mueller, Steffen
A1  - Mayer, Frank
A1  - Wochatz, Monique
A1  - Hadzic, Miralem
A1  - John, Michael
A1  - Wegscheider, Karl
A1  - Völler, Heinz
T1  - The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement
BT  - Randomized Controlled Trial
T2  - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Background: Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare.

Objective: The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare.

Methods: From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints.

Results: Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note.

Conclusions: The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 589 
KW  - telerehabilitation
KW  - home-based
KW  - total hip replacement
KW  - total knee replacement
KW  - exercise therapy
KW  - aftercare
KW  - rehabilitation
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440965
SN  - 1866-8364
IS  - 589
ER  - 
TY  - JOUR
A1  - Haubitz, Toni
A1  - John, Leonard
A1  - Freyse, Daniel
A1  - Wessig, Pablo
A1  - Kumke, Michael Uwe
T1  - Investigating the Sulfur "Twist" on the Photophysics of DBD Dyes
JF  - The journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment & general theory
N2  - The so-called DBD ([1,3]dioxolo[4,5-f][1,3]benzodioxole) dyes are a new class of fluorescent dyes, with tunable photophysical properties like absorption, fluorescence lifetime, and Stokes shift. With the development of sulfur based DBDs, this dye class is extended even further for possible applications in spectroscopy and microscopy. In this paper we are investigating the basic photophysical properties and their implications for future applications for S-4-DBD as well as O-4-DBD. On the basis of time-resolved laser fluorescence spectroscopy, transient absorption spectroscopy, and UV/vis-spectroscopy, we determined the rate constants of the radiative and nonradiative deactivation processes as well as the energy of respective electronic states involved in the electronic deactivation of S-4-DBD and of O-4-DBD. For S-4-DBD we unraveled the triplet formation with intersystem crossing quantum yields of up to 80%. By TD-DFT calculations we estimated a triplet energy of around 13500-14700 cm(-1) depending on the DBD dye and solvent. Through solvent dependent measurements, we found quadrupole moments in the range of 2 B.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jpca.0c01880
SN  - 1089-5639
SN  - 1520-5215
VL  - 124
IS  - 22
SP  - 4345
EP  - 4353
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Johnson, Sean D.
A1  - Chen, Hsiao-Wen
A1  - Straka, Lorrie
A1  - Schaye, Joop
A1  - Cantalupo, Sebastiano
A1  - Wendt, Martin
A1  - Muzahid, Sowgat
A1  - Bouché, Nicolas
A1  - Herenz, Edmund Christian
A1  - Kollatschny, Wolfram
A1  - Mulchaey, John S.
A1  - Marino, Raffaella A.
A1  - Maseda, Michael
A1  - Wisotzki, Lutz
T1  - Galaxy and quasar fueling caught in the act from the intragroup to the interstellar medium
JF  - The astrophysical journal : Part 2, Letters
N2  - We report the discovery of six spatially extended (10-100 kpc) line-emitting nebulae in the z approximate to 0.57 galaxy group hosting PKS 0405-123, one of the most luminous quasars at z < 1. The discovery is enabled by the Multi Unit Spectroscopic Explorer and provides tantalizing evidence connecting large-scale gas streams with nuclear activity on scales of <10 proper kpc (pkpc). One of the nebulae exhibits a narrow, filamentary morphology extending over 50 pkpc toward the quasar with narrow internal velocity dispersion (50 km s(-1)) and is not associated with any detected galaxies, consistent with a cool intragroup medium filament. Two of the nebulae are 10 pkpc north and south of the quasar with tidal-arm-like morphologies. These two nebulae, along with a continuum-emitting arm extending 60 pkpc from the quasar, are signatures of interactions that are expected to redistribute angular momentum in the host interstellar medium (ISM) to facilitate star formation and quasar fueling in the nucleus. The three remaining nebulae are among the largest and most luminous [O III] emitting "blobs" known (1400-2400 pkpc(2)) and correspond both kinematically and morphologically to interacting galaxy pairs in the quasar host group, consistent with arising from stripped ISM rather than large-scale quasar outflows. The presence of these large- and small-scale nebulae in the vicinity of a luminous quasar bears significantly on the effect of large-scale environment on galaxy and black hole fueling, providing a natural explanation for the previously known correlation between quasar luminosity and cool circumgalactic medium.
KW  - galaxies: interactions
KW  - intergalactic medium
KW  - quasars: general
KW  - quasars: individual (PKS 0405-123)
Y1  - 2018
U6  - https://doi.org/10.3847/2041-8213/aaf1cf
SN  - 2041-8205
SN  - 2041-8213
VL  - 869
IS  - 1
PB  - IOP Publishing Ltd. (Bristol)
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Fages, Antoine
A1  - Hanghoj, Kristian
A1  - Khan, Naveed
A1  - Gaunitz, Charleen
A1  - Seguin-Orlando, Andaine
A1  - Leonardi, Michela
A1  - Constantz, Christian McCrory
A1  - Gamba, Cristina
A1  - Al-Rasheid, Khaled A. S.
A1  - Albizuri, Silvia
A1  - Alfarhan, Ahmed H.
A1  - Allentoft, Morten
A1  - Alquraishi, Saleh
A1  - Anthony, David
A1  - Baimukhanov, Nurbol
A1  - Barrett, James H.
A1  - Bayarsaikhan, Jamsranjav
A1  - Benecke, Norbert
A1  - Bernaldez-Sanchez, Eloisa
A1  - Berrocal-Rangel, Luis
A1  - Biglari, Fereidoun
A1  - Boessenkool, Sanne
A1  - Boldgiv, Bazartseren
A1  - Brem, Gottfried
A1  - Brown, Dorcas
A1  - Burger, Joachim
A1  - Crubezy, Eric
A1  - Daugnora, Linas
A1  - Davoudi, Hossein
A1  - Damgaard, Peter de Barros
A1  - de Chorro y de Villa-Ceballos, Maria de los Angeles
A1  - Deschler-Erb, Sabine
A1  - Detry, Cleia
A1  - Dill, Nadine
A1  - Oom, Maria do Mar
A1  - Dohr, Anna
A1  - Ellingvag, Sturla
A1  - Erdenebaatar, Diimaajav
A1  - Fathi, Homa
A1  - Felkel, Sabine
A1  - Fernandez-Rodriguez, Carlos
A1  - Garcia-Vinas, Esteban
A1  - Germonpre, Mietje
A1  - Granado, Jose D.
A1  - Hallsson, Jon H.
A1  - Hemmer, Helmut
A1  - Hofreiter, Michael
A1  - Kasparov, Aleksei
A1  - Khasanov, Mutalib
A1  - Khazaeli, Roya
A1  - Kosintsev, Pavel
A1  - Kristiansen, Kristian
A1  - Kubatbek, Tabaldiev
A1  - Kuderna, Lukas
A1  - Kuznetsov, Pavel
A1  - Laleh, Haeedeh
A1  - Leonard, Jennifer A.
A1  - Lhuillier, Johanna
A1  - von Lettow-Vorbeck, Corina Liesau
A1  - Logvin, Andrey
A1  - Lougas, Lembi
A1  - Ludwig, Arne
A1  - Luis, Cristina
A1  - Arruda, Ana Margarida
A1  - Marques-Bonet, Tomas
A1  - Silva, Raquel Matoso
A1  - Merz, Victor
A1  - Mijiddorj, Enkhbayar
A1  - Miller, Bryan K.
A1  - Monchalov, Oleg
A1  - Mohaseb, Fatemeh A.
A1  - Morales, Arturo
A1  - Nieto-Espinet, Ariadna
A1  - Nistelberger, Heidi
A1  - Onar, Vedat
A1  - Palsdottir, Albina H.
A1  - Pitulko, Vladimir
A1  - Pitskhelauri, Konstantin
A1  - Pruvost, Melanie
A1  - Sikanjic, Petra Rajic
A1  - Papesa, Anita Rapan
A1  - Roslyakova, Natalia
A1  - Sardari, Alireza
A1  - Sauer, Eberhard
A1  - Schafberg, Renate
A1  - Scheu, Amelie
A1  - Schibler, Jorg
A1  - Schlumbaum, Angela
A1  - Serrand, Nathalie
A1  - Serres-Armero, Aitor
A1  - Shapiro, Beth
A1  - Seno, Shiva Sheikhi
A1  - Shevnina, Irina
A1  - Shidrang, Sonia
A1  - Southon, John
A1  - Star, Bastiaan
A1  - Sykes, Naomi
A1  - Taheri, Kamal
A1  - Taylor, William
A1  - Teegen, Wolf-Rudiger
A1  - Vukicevic, Tajana Trbojevic
A1  - Trixl, Simon
A1  - Tumen, Dashzeveg
A1  - Undrakhbold, Sainbileg
A1  - Usmanova, Emma
A1  - Vahdati, Ali
A1  - Valenzuela-Lamas, Silvia
A1  - Viegas, Catarina
A1  - Wallner, Barbara
A1  - Weinstock, Jaco
A1  - Zaibert, Victor
A1  - Clavel, Benoit
A1  - Lepetz, Sebastien
A1  - Mashkour, Marjan
A1  - Helgason, Agnar
A1  - Stefansson, Kari
A1  - Barrey, Eric
A1  - Willerslev, Eske
A1  - Outram, Alan K.
A1  - Librado, Pablo
A1  - Orlando, Ludovic
T1  - Tracking five millennia of horse management with extensive ancient genome time series
JF  - Cell
N2  - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (>= 1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modem legacy of past equestrian civilisations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN "speed gene," only rose in popularity within the last millennium. Finally, the development of modem breeding impacted genetic diversity more dramatically than the previous millennia of human management.
Y1  - 2019
U6  - https://doi.org/10.1016/j.cell.2019.03.049
SN  - 0092-8674
SN  - 1097-4172
VL  - 177
IS  - 6
SP  - 1419
EP  - 1435
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Dengler, Jürgen
A1  - Wagner, Viktoria
A1  - Dembicz, Iwona
A1  - Garcia-Mijangos, Itziar
A1  - Naqinezhad, Alireza
A1  - Boch, Steffen
A1  - Chiarucci, Alessandro
A1  - Conradi, Timo
A1  - Filibeck, Goffredo
A1  - Guarino, Riccardo
A1  - Janisova, Monika
A1  - Steinbauer, Manuel J.
A1  - Acic, Svetlana
A1  - Acosta, Alicia T. R.
A1  - Akasaka, Munemitsu
A1  - Allers, Marc-Andre
A1  - Apostolova, Iva
A1  - Axmanova, Irena
A1  - Bakan, Branko
A1  - Baranova, Alina
A1  - Bardy-Durchhalter, Manfred
A1  - Bartha, Sandor
A1  - Baumann, Esther
A1  - Becker, Thomas
A1  - Becker, Ute
A1  - Belonovskaya, Elena
A1  - Bengtsson, Karin
A1  - Benito Alonso, Jose Luis
A1  - Berastegi, Asun
A1  - Bergamini, Ariel
A1  - Bonini, Ilaria
A1  - Bruun, Hans Henrik
A1  - Budzhak, Vasyl
A1  - Bueno, Alvaro
A1  - Antonio Campos, Juan
A1  - Cancellieri, Laura
A1  - Carboni, Marta
A1  - Chocarro, Cristina
A1  - Conti, Luisa
A1  - Czarniecka-Wiera, Marta
A1  - De Frenne, Pieter
A1  - Deak, Balazs
A1  - Didukh, Yakiv P.
A1  - Diekmann, Martin
A1  - Dolnik, Christian
A1  - Dupre, Cecilia
A1  - Ecker, Klaus
A1  - Ermakov, Nikolai
A1  - Erschbamer, Brigitta
A1  - Escudero, Adrian
A1  - Etayo, Javier
A1  - Fajmonova, Zuzana
A1  - Felde, Vivian A.
A1  - Fernandez Calzado, Maria Rosa
A1  - Finckh, Manfred
A1  - Fotiadis, Georgios
A1  - Fracchiolla, Mariano
A1  - Ganeva, Anna
A1  - Garcia-Magro, Daniel
A1  - Gavilan, Rosario G.
A1  - Germany, Markus
A1  - Giladi, Itamar
A1  - Gillet, Francois
A1  - Giusso del Galdo, Gian Pietro
A1  - Gonzalez, Jose M.
A1  - Grytnes, John-Arvid
A1  - Hajek, Michal
A1  - Hajkova, Petra
A1  - Helm, Aveliina
A1  - Herrera, Mercedes
A1  - Hettenbergerova, Eva
A1  - Hobohm, Carsten
A1  - Huellbusch, Elisabeth M.
A1  - Ingerpuu, Nele
A1  - Jandt, Ute
A1  - Jeltsch, Florian
A1  - Jensen, Kai
A1  - Jentsch, Anke
A1  - Jeschke, Michael
A1  - Jimenez-Alfaro, Borja
A1  - Kacki, Zygmunt
A1  - Kakinuma, Kaoru
A1  - Kapfer, Jutta
A1  - Kavgaci, Ali
A1  - Kelemen, Andras
A1  - Kiehl, Kathrin
A1  - Koyama, Asuka
A1  - Koyanagi, Tomoyo F.
A1  - Kozub, Lukasz
A1  - Kuzemko, Anna
A1  - Kyrkjeeide, Magni Olsen
A1  - Landi, Sara
A1  - Langer, Nancy
A1  - Lastrucci, Lorenzo
A1  - Lazzaro, Lorenzo
A1  - Lelli, Chiara
A1  - Leps, Jan
A1  - Loebel, Swantje
A1  - Luzuriaga, Arantzazu L.
A1  - Maccherini, Simona
A1  - Magnes, Martin
A1  - Malicki, Marek
A1  - Marceno, Corrado
A1  - Mardari, Constantin
A1  - Mauchamp, Leslie
A1  - May, Felix
A1  - Michelsen, Ottar
A1  - Mesa, Joaquin Molero
A1  - Molnar, Zsolt
A1  - Moysiyenko, Ivan Y.
A1  - Nakaga, Yuko K.
A1  - Natcheva, Rayna
A1  - Noroozi, Jalil
A1  - Pakeman, Robin J.
A1  - Palpurina, Salza
A1  - Partel, Meelis
A1  - Paetsch, Ricarda
A1  - Pauli, Harald
A1  - Pedashenko, Hristo
A1  - Peet, Robert K.
A1  - Pielech, Remigiusz
A1  - Pipenbaher, Natasa
A1  - Pirini, Chrisoula
A1  - Pleskova, Zuzana
A1  - Polyakova, Mariya A.
A1  - Prentice, Honor C.
A1  - Reinecke, Jennifer
A1  - Reitalu, Triin
A1  - Pilar Rodriguez-Rojo, Maria
A1  - Rolecek, Jan
A1  - Ronkin, Vladimir
A1  - Rosati, Leonardo
A1  - Rosen, Ejvind
A1  - Ruprecht, Eszter
A1  - Rusina, Solvita
A1  - Sabovljevic, Marko
A1  - Maria Sanchez, Ana
A1  - Savchenko, Galina
A1  - Schuhmacher, Oliver
A1  - Skornik, Sonja
A1  - Sperandii, Marta Gaia
A1  - Staniaszek-Kik, Monika
A1  - Stevanovic-Dajic, Zora
A1  - Stock, Marin
A1  - Suchrow, Sigrid
A1  - Sutcliffe, Laura M. E.
A1  - Swacha, Grzegorz
A1  - Sykes, Martin
A1  - Szabo, Anna
A1  - Talebi, Amir
A1  - Tanase, Catalin
A1  - Terzi, Massimo
A1  - Tolgyesi, Csaba
A1  - Torca, Marta
A1  - Torok, Peter
A1  - Tothmeresz, Bela
A1  - Tsarevskaya, Nadezda
A1  - Tsiripidis, Ioannis
A1  - Tzonev, Rossen
A1  - Ushimaru, Atushi
A1  - Valko, Orsolya
A1  - van der Maarel, Eddy
A1  - Vanneste, Thomas
A1  - Vashenyak, Iuliia
A1  - Vassilev, Kiril
A1  - Viciani, Daniele
A1  - Villar, Luis
A1  - Virtanen, Risto
A1  - Kosic, Ivana Vitasovic
A1  - Wang, Yun
A1  - Weiser, Frank
A1  - Went, Julia
A1  - Wesche, Karsten
A1  - White, Hannah
A1  - Winkler, Manuela
A1  - Zaniewski, Piotr T.
A1  - Zhang, Hui
A1  - Ziv, Yaron
A1  - Znamenskiy, Sergey
A1  - Biurrun, Idoia
T1  - GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands
JF  - Phytocoenologia
N2  - GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
KW  - biodiversity
KW  - European Vegetation Archive (EVA)
KW  - Eurasian Dry Grassland Group (EDGG)
KW  - grassland vegetation
KW  - GrassPlot
KW  - macroecology
KW  - multi-taxon
KW  - nested plot
KW  - scale-dependence
KW  - species-area relationship (SAR)
KW  - sPlot
KW  - vegetation-plot database
Y1  - 2018
U6  - https://doi.org/10.1127/phyto/2018/0267
SN  - 0340-269X
VL  - 48
IS  - 3
SP  - 331
EP  - 347
PB  - Cramer
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - López de Guereñu, Anna
A1  - Bastian, Philipp
A1  - Wessig, Pablo
A1  - John, Leonard
A1  - Kumke, Michael Uwe
T1  - Energy Transfer between Tm-Doped Upconverting Nanoparticles and a Small Organic Dye with Large Stokes Shift
JF  - Biosensors : open access journal
N2  - Lanthanide-doped upconverting nanoparticles (UCNP) are being extensively studied for bioapplications due to their unique photoluminescence properties and low toxicity. Interest in RET applications involving UCNP is also increasing, but due to factors such as large sizes, ion emission distributions within the particles, and complicated energy transfer processes within the UCNP, there are still many questions to be answered. In this study, four types of core and core-shell NaYF4-based UCNP co-doped with Yb3+ and Tm3+ as sensitizer and activator, respectively, were investigated as donors for the Methyl 5-(8-decanoylbenzo[1,2-d:4,5-d ']bis([1,3]dioxole)-4-yl)-5-oxopentanoate (DBD-6) dye. The possibility of resonance energy transfer (RET) between UCNP and the DBD-6 attached to their surface was demonstrated based on the comparison of luminescence intensities, band ratios, and decay kinetics. The architecture of UCNP influenced both the luminescence properties and the energy transfer to the dye: UCNP with an inert shell were the brightest, but their RET efficiency was the lowest (17%). Nanoparticles with Tm3+ only in the shell have revealed the highest RET efficiencies (up to 51%) despite the compromised luminescence due to surface quenching.
KW  - resonance energy transfer
KW  - DBD dye
KW  - core shell UCNP
KW  - time-resolved luminescence
Y1  - 2019
U6  - https://doi.org/10.3390/bios9010009
SN  - 2079-6374
VL  - 9
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Haubitz, Toni
A1  - John, Leonard
A1  - Wessig, Pablo
A1  - Kumke, Michael Uwe
T1  - Photophysics of Acyl- and Ester-DBD Dyes
BT  - Quadrupole-Induced Solvent Relaxation Investigated by Transient Absorption Spectroscopy
JF  - the journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment & general theory
N2  - A new generation of wavelength-tunable, fluorescent dyes, so-called DBD ([1,3]dioxolo[4,5-f][1,3]benzodioxole) dyes, were developed a few years ago, and they showed great potential as probes, for example, for fluorescence microscopy. However, their photophysics is not fully explored and leaves open questions regarding their large fluorescence Stokes shifts and sensitivity to solvent conditions of differently substituted DBD dyes. To improve the understanding of the influence of the substitution pattern of the DBD dyes on their respective photophysics, transient absorption spectroscopy (TAS) was used, that is, a pump-probe experiment on the femtosecond timescale. TAS allows measurements of excited states, ground state recovery, solvent relaxation, and fluorescence properties on time scales of up to several nanoseconds. Two different DBD dye samples were investigated: aryl- and ester-substituted DBD dyes. Experiments were carried out in solvents with different polarities using different excitation energies and at different viscosities. Based on the experimental data and theoretical calculations, we were able to determine the conformational changes of the molecule due to electronic excitation and were able to investigate solvent relaxation processes for both types of DBD dyes. By generalizing the theory for quadrupole-induced solvent relaxation developed by Togashi et al., we derived quadrupole moments of both molecules in the ground and excited state. Our data showed differences in the binding of polar solvent molecules to the dyes depending on the substituent on the DBD dye. In the case of water as the solvent, an additional efficient quenching process in the electronically excited state was revealed, which was indicated by the observation of solvated electrons in the TAS signals.
Y1  - 2019
U6  - https://doi.org/10.1021/acs.jpca.9b02973
SN  - 1089-5639
VL  - 123
IS  - 22
SP  - 4717
EP  - 4726
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Cassel, Michael
A1  - Carlsohn, Anja
A1  - Fröhlich, Katja
A1  - John, Mareike
A1  - Riegels, N.
A1  - Mayer, Frank
T1  - Tendon Adaptation to Sport-specific Loading in Adolescent Athletes
JF  - International journal of sports medicine
N2  - Tendon adaptation due to mechanical loading is controversially discussed. However, data concerning the development of tendon thickness in adolescent athletes is sparse. The purpose of this study was to examine possible differences in Achilles (AT) and patellar tendon (PT) thickness in adolescent athletes while considering age, gender and sport-specific loading. In 500 adolescent competitive athletes of 16 different sports and 40 recreational controls both ATs and PTs were sonographically measured. Subjects were divided into 2 age groups (< 13; &#8805; 13 years) and 6 sport type categories (ball, combat, and water sports, combined disciplines, cycling, controls). In addition, 3 risk groups (low, moderate, high) were created according to the athlete’s risk of developing tendinopathy. AT and PT thickness did not significantly differ between age groups (AT/PT:<13: 5.4±0.7 mm/3.6±0.5 mm;&#8805;13: 5.3±0.7 mm/3.6±0.5 mm). In both age groups males presented higher tendon thickness than females (p<0.001). AT thickness was highest in ball sports/cyclists and lowest in controls (p&#8804;0.002). PT thickness was greatest in water sports and lowest in controls (p=0.02). High risk athletes presented slightly higher AT thickness compared to the low risk group (p=0.03). Increased AT and PT thickness in certain sport types compared to controls supports the hypothesis of structural tendon adaptation due to sport-specific loading.
KW  - achilles and patellar tendon
KW  - training adaptation
KW  - tendon thickness
KW  - standard values
KW  - sonography
Y1  - 2016
U6  - https://doi.org/10.1055/s-0035-1559772
SN  - 0172-4622
SN  - 1439-3964
VL  - 37
SP  - 159
EP  - 164
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Linley, John E.
A1  - Boese, Stefan H.
A1  - Simmons, Nicholas L.
A1  - Gray, Michael A.
T1  - A voltage-dependent Ca2+ influx pathway regulates the Ca2+-dependent Cl- conductance of renal IMCD-3 cells
N2  - We have previously shown that the membrane conductance of mIMCD-3 cells at a holding potential of 0 mV is dominated by a Ca2+-dependent Cl- current (I-CLCA). Here we report that I-CLCA activity is also voltage dependent and that this dependence on voltage is linked to the opening of a novel Al3+-sensitive, voltage-dependent, Ca2+ influx pathway. Using whole-cell patch-clamp recordings at a physiological holding potential (-60 mV), I-CLCA was found to be inactive and resting currents were predominantly K+ selective. However, membrane depolarization to 0 mV resulted in a slow, sigmoidal, activation of I-CLCA (T (0.5) similar to 500 s), while repolarization in turn resulted in a monoexponential decay in I-CLCA (T (0.5) similar to 100 s). The activation of I-CLCA by depolarization was reduced by lowering extracellular Ca2+ and completely inhibited by buffering cytosolic Ca2+ with EGTA, suggesting a role for Ca2+ influx in the activation of I-CLCA. However, raising bulk cytosolic Ca2+ at -60 mV did not produce sustained I-CLCA activity. Therefore I-CLCA is dependent on both an increase in intracellular Ca2+ and depolarization to be active. We further show that membrane depolarization is coupled to opening of a Ca2+ influx pathway that displays equal permeability to Ca2+ and Ba2+ ions and that is blocked by extracellular Al3+ and La3+. Furthermore, Al3+ completely and reversibly inhibited depolarization-induced activation of I-CLCA, thereby directly linking Ca2+ influx to activation of I-CLCA. We speculate that during sustained membrane depolarization, calcium influx activates I-CLCA which functions to modulate NaCl transport across the apical membrane of IMCD cells.
Y1  - 2009
UR  - http://www.springerlink.com/content/100360
U6  - https://doi.org/10.1007/s00232-009-9186-0
SN  - 0022-2631
ER  - 
TY  - JOUR
A1  - Schorck, Torben
A1  - Christlieb, Norbert
A1  - Cohen, Judy G.
A1  - Beers, Timothy C.
A1  - Shectman, Steve
A1  - Thompson, Ian
A1  - McWilliam, Andrew
A1  - Bessell, Michael S.
A1  - Norris, John E.
A1  - Meléndez, Jorge
A1  - Ramïrez, Solange
A1  - Haynes, D.
A1  - Cass, Paul
A1  - Hartley, Malcolm
A1  - Russell, Ken
A1  - Watson, Fred
A1  - Zickgraf, Franz-Josef
A1  - Behnke, Berit
A1  - Fechner, Cora
A1  - Fuhrmeister, Birgit
A1  - Barklem, Paul S.
A1  - Edvardsson, Bengt
A1  - Frebel, Anna
A1  - Wisotzki, Lutz
A1  - Reimers, Dieter
T1  - The stellar content of the Hamburg/ESO survey : V. the metallicity distribution function of the Galactic halo
N2  - We determine the metallicity distribution function (MDF) of the Galactic halo by means of a sample of 1638 metal-poor stars selected from the Hamburg/ESO objective-prism survey (HES). The sample was corrected for minor biases introduced by the strategy for spectroscopic follow-up observations of the metal-poor candidates, namely "best and brightest stars first". Comparison of the metallicities [Fe/H] of the stars determined from moderate-resolution (i.e., R similar to 2000) follow-up spectra with results derived from abundance analyses based on high-resolution spectra (i.e., R > 20 000) shows that the [Fe/H] estimates used for the determination of the halo MDF are accurate to within 0.3 dex, once highly C-rich stars are eliminated. We determined the selection function of the HES, which must be taken into account for a proper comparison between the HES MDF with MDFs of other stellar populations or those predicted by models of Galactic chemical evolution. The latter show a reasonable agreement with the overall shape of the HES MDF for [Fe/H] > -3.6, but only a model of Salvadori et al. (2007) with a critical metallicity for low-mass star formation of Z(cr) = 10(-3.4) Z(circle dot) reproduces the sharp drop at [Fe/H] similar to -3.6 present in the HES MDF. Although currently about ten stars at [Fe/H] < -3.6 are known, the evidence for the existence of a tail of the halo MDF extending to [Fe/H] similar to -5.5 is weak from the sample considered in this paper, because it only includes two stars [Fe/H] < -3.6. Therefore, a comparison with theoretical models has to await larger statistically complete and unbiased samples. A comparison of the MDF of Galactic globular clusters and of dSph satellites to the Galaxy shows qualitative agreement with the halo MDF, derived from the HES, once the selection function of the latter is included. However, statistical tests show that the differences between these are still highly significant.
Y1  - 2009
UR  - http://www.aanda.org/
U6  - https://doi.org/10.1051/0004-6361/200810925
SN  - 0004-6361
ER  - 
TY  - JOUR
A1  - Lim, Sze Chern
A1  - Friemel, Martin
A1  - Marum, Justine E.
A1  - Tucker, Elena J.
A1  - Bruno, Damien L.
A1  - Riley, Lisa G.
A1  - Christodoulou, John
A1  - Kirk, Edwin P.
A1  - Boneh, Avihu
A1  - DeGennaro, Christine M.
A1  - Springer, Michael
A1  - Mootha, Vamsi K.
A1  - Rouault, Tracey A.
A1  - Leimkühler, Silke
A1  - Thorburn, David R.
A1  - Compton, Alison G.
T1  - Mutations in LYRM4, encoding ironsulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes
JF  - Human molecular genetics
N2  - Ironsulfur clusters (ISCs) are important prosthetic groups that define the functions of many proteins. Proteins with ISCs (called ironsulfur or FeS proteins) are present in mitochondria, the cytosol, the endoplasmic reticulum and the nucleus. They participate in various biological pathways including oxidative phosphorylation (OXPHOS), the citric acid cycle, iron homeostasis, heme biosynthesis and DNA repair. Here, we report a homozygous mutation in LYRM4 in two patients with combined OXPHOS deficiency. LYRM4 encodes the ISD11 protein, which forms a complex with, and stabilizes, the sulfur donor NFS1. The homozygous mutation (c.203GT, p.R68L) was identified via massively parallel sequencing of 1000 mitochondrial genes (MitoExome sequencing) in a patient with deficiency of complexes I, II and III in muscle and liver. These three complexes contain ISCs. Sanger sequencing identified the same mutation in his similarly affected cousin, who had a more severe phenotype and died while a neonate. Complex IV was also deficient in her skeletal muscle. Several other FeS proteins were also affected in both patients, including the aconitases and ferrochelatase. Mutant ISD11 only partially complemented for an ISD11 deletion in yeast. Our in vitro studies showed that the l-cysteine desulfurase activity of NFS1 was barely present when co-expressed with mutant ISD11. Our findings are consistent with a defect in the early step of ISC assembly affecting a broad variety of FeS proteins. The differences in biochemical and clinical features between the two patients may relate to limited availability of cysteine in the newborn period and suggest a potential approach to therapy.
Y1  - 2013
U6  - https://doi.org/10.1093/hmg/ddt295
SN  - 0964-6906
SN  - 1460-2083
VL  - 22
IS  - 22
SP  - 4460
EP  - 4473
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Hector, Andy
A1  - Hautier, Yann
A1  - Saner, Philippe
A1  - Wacker, Lukas
A1  - Bagchi, Robert
A1  - Joshi, Jasmin Radha
A1  - Scherer-Lorenzen, Michael
A1  - Spehn, Eva M.
A1  - Bazeley-White, Ellen
A1  - Weilenmann, Markus
A1  - Caldeira, Maria da Conceição Brálio de Brito
A1  - Dimitrakopoulos, Panayiotis G.
A1  - Finn, John A.
A1  - Huss-Danell, Kerstin
A1  - Jumpponen, Ari
A1  - Mulder, Christa P. H.
A1  - Palmborg, Cecilia
A1  - Pereira, J. S.
A1  - Siamantziouras, Akis S. D.
A1  - Terry, Andrew C.
A1  - Troumbis, Andreas Y.
A1  - Schmid, Bernhard
A1  - Loreau, Michel
T1  - General stabilizing effects of plant diversity on grassland productivity through population asynchrony and overyielding
N2  - Insurance effects of biodiversity can stabilize the functioning of multispecies ecosystems against environmental variability when differential species' responses lead to asynchronous population dynamics. When responses are not perfectly positively correlated, declines in some populations are compensated by increases in others, smoothing variability in ecosystem productivity. This variance reduction effect of biodiversity is analogous to the risk- spreading benefits of diverse investment portfolios in financial markets. We use data from the BIODEPTH network of grassland biodiversity experiments to perform a general test for stabilizing effects of plant diversity on the temporal variability of individual species, functional groups, and aggregate communities. We tested three potential mechanisms: reduction of temporal variability through population asynchrony; enhancement of long-term average performance through positive selection effects; and increases in the temporal mean due to overyielding. Our results support a stabilizing effect of diversity on the temporal variability of grassland aboveground annual net primary production through two mechanisms. Two-species communities with greater population asynchrony were more stable in their average production over time due to compensatory fluctuations. Overyielding also stabilized productivity by increasing levels of average biomass production relative to temporal variability. However, there was no evidence for a performance-enhancing effect on the temporal mean through positive selection effects. In combination with previous work, our results suggest that stabilizing effects of diversity on community productivity through population asynchrony and overyielding appear to be general in grassland ecosystems.
Y1  - 2010
UR  - http://esapubs.org/esapubs/journals/ecology.htm
SN  - 0012-9658
ER  - 
TY  - JOUR
A1  - Gevers, Jana
A1  - Hoye, Toke Thomas
A1  - Topping, Chris John
A1  - Glemnitz, Michael
A1  - Schroeder, Boris
T1  - Biodiversity and the mitigation of climate change through bioenergy  impacts of increased maize cultivation on farmland wildlife
JF  - Global change biology : Bioenergy
N2  - The public promotion of renewable energies is expected to increase the number of biogas plants and stimulate energy crops cultivation (e. g. maize) in Germany. In order to assess the indirect effects of the resulting land-use changes on biodiversity, we developed six land-use scenarios and simulated the responses of six farmland wildlife species with the spatially explicit agent-based model system ALMaSS. The scenarios differed in composition and spatial configuration of arable crops. We implemented scenarios where maize for energy production replaced 15% and 30% of the area covered by other cash crops. Biogas maize farms were either randomly distributed or located within small or large aggregation clusters. The animal species investigated were skylark (Alauda arvensis), grey partridge (Perdix perdix), European brown hare (Lepus europaeus), field vole (Microtus agrestis), a linyphiid spider (Erigone atra) and a carabid beetle (Bembidion lampros). The changes in crop composition had a negative effect on the population sizes of skylark, partridge and hare and a positive effect on the population sizes of spider and beetle and no effect on the population size of vole. An aggregated cultivation of maize amplified these effects for skylark. Species responses to changes in the crop composition were consistent across three differently structured landscapes. Our work suggests that with the compliance to some recommendations, negative effects of biogas-related land-use change on the populations of the six representative farmland species can largely be avoided.
KW  - agriculture
KW  - ALMaSS
KW  - biogas
KW  - farmland biodiversity
KW  - land-use change
KW  - maize
KW  - spatially explicit agent-based modeling
Y1  - 2011
U6  - https://doi.org/10.1111/j.1757-1707.2011.01104.x
SN  - 1757-1693
VL  - 3
IS  - 6
SP  - 472
EP  - 482
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Love, John A.
A1  - Feuerstein, Markus
A1  - Wolff, Christian Michael
A1  - Facchetti, Antonio
A1  - Neher, Dieter
T1  - Lead Halide Perovskites as Charge Generation Layers for Electron Mobility Measurement in Organic Semiconductors
JF  - ACS applied materials & interfaces
N2  - Hybrid lead halide perovskites are introduced as charge generation layers (CGLs) for the accurate determination of electron mobilities in thin organic semiconductors. Such hybrid perovskites have become a widely studied photovoltaic material in their own right, for their high efficiencies, ease of processing from solution, strong absorption, and efficient photogeneration of charge. Time-of-flight (ToF) measurements on bilayer samples consisting of the perovskite CGL and an organic semiconductor layer of different thickness are shown to be determined by the carrier motion through the organic material, consistent with the much higher charge carrier mobility in the perovskite. Together with the efficient photon-to-electron conversion in the perovskite, this high mobility imbalance enables electron-only mobility measurement on relatively thin application-relevant organic films, which would not be possible with traditional ToF measurements. This architecture enables electron-selective mobility measurements in single components as well as bulk-heterojunction films as demonstrated in the prototypical polymer/fullerene blends. To further demonstrate the potential of this approach, electron mobilities were measured as a function of electric field and temperature in an only 127 nm thick layer of a prototypical electron-transporting perylene diimide-based polymer, and found to be consistent with an exponential trap distribution of ca. 60 meV. Our study furthermore highlights the importance of high mobility charge transporting layers when designing perovskite solar cells.
KW  - mobility
KW  - bulk heterojunction
KW  - time of flight
KW  - lead halide perovskites
KW  - charge generation layers
Y1  - 2017
U6  - https://doi.org/10.1021/acsami.7b10361
SN  - 1944-8244
VL  - 9
SP  - 42011
EP  - 42019
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Eichler, Sarah
A1  - Rabe, Sophie
A1  - Salzwedel, Annett
A1  - Müller, Steffen
A1  - Stoll, Josefine
A1  - Tilgner, Nina
A1  - John, Michael
A1  - Wegschneider, Karl
A1  - Mayer, Frank
A1  - Völler, Heinz
T1  - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement
BT  - Study protocol for a multicenter, superiority, no-blinded randomized controlled trial
JF  - Trials
N2  - Background

Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain.

Methods/design

This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints.

Discussion

We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas.
KW  - Telerehabilitation
KW  - Home-based
KW  - Total hip replacement
KW  - Total knee replacement
KW  - Exercise therapy
KW  - Aftercare
Y1  - 2017
U6  - https://doi.org/10.1186/s13063-017-2173-3
SN  - 1745-6215
VL  - 18
SP  - 1
EP  - 7
PB  - BioMed Central
CY  - London
ER  - 
TY  - GEN
A1  - Eichler, Sarah
A1  - Rabe, Sophie
A1  - Salzwedel, Annett
A1  - Müller, Steffen
A1  - Stoll, Josefine
A1  - Tilgner, Nina
A1  - John, Michael
A1  - Wegschneider, Karl
A1  - Mayer, Frank
A1  - Völler, Heinz
T1  - Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement
BT  - Study protocol for a multicenter, superiority, no-blinded randomized controlled trial
N2  - Background

Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain.

Methods/design

This is an open, randomized controlled, multicenter superiority study with two prospective arms. One hundred and ten eligible and consenting participants with total knee or hip replacement will be recruited at admission to subsequent inpatient rehabilitation. After comprehensive, 3-week, inpatient rehabilitation, the intervention group performs a 3-month, interactive, home-based exercise training with a telerehabilitation system. For this purpose, the physiotherapist creates an individual training plan out of 38 different strength and balance exercises which were implemented in the system. Data about the quality and frequency of training are transmitted to the physiotherapist for further adjustment. Communication between patient and physiotherapist is possible with the system. The control group receives voluntary, usual aftercare programs. Baseline assessments are investigated after discharge from rehabilitation; final assessments 3 months later. The primary outcome is the difference in improvement between intervention and control group in 6-minute walk distance after 3 months. Secondary outcomes include differences in the Timed Up and Go Test, the Five-Times-Sit-to-Stand Test, the Stair Ascend Test, the Short-Form 36, the Western Ontario and McMaster Universities Osteoarthritis Index, the International Physical Activity Questionnaire, and postural control as well as gait and kinematic parameters of the lower limbs. Baseline-adjusted analysis of covariance models will be used to test for group differences in the primary and secondary endpoints.

Discussion

We expect the intervention group to benefit from the interactive, home-based exercise training in many respects represented by the study endpoints. If successful, this approach could be used to enhance the access to aftercare programs, especially in structurally weak areas.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 353 
KW  - Aftercare
KW  - Exercise therapy
KW  - Home-based
KW  - Telerehabilitation
KW  - Total hip replacement
KW  - Total knee replacement
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-403702
ER  - 
TY  - JOUR
A1  - Ran, Niva A.
A1  - Roland, Steffen
A1  - Love, John A.
A1  - Savikhin, Victoria
A1  - Takacs, Christopher J.
A1  - Fu, Yao-Tsung
A1  - Li, Hong
A1  - Coropceanu, Veaceslav
A1  - Liu, Xiaofeng
A1  - Bredas, Jean-Luc
A1  - Bazan, Guillermo C.
A1  - Toney, Michael F.
A1  - Neher, Dieter
A1  - Thuc-Quyen Nguyen, 
T1  - Impact of interfacial molecular orientation on radiative recombination and charge generation efficiency
JF  - Nature Communications
N2  - A long standing question in organic electronics concerns the effects of molecular orientation at donor/acceptor heterojunctions. Given a well-controlled donor/acceptor bilayer system, we uncover the genuine effects of molecular orientation on charge generation and recombination. These effects are studied through the point of view of photovoltaics-however, the results have important implications on the operation of all optoelectronic devices with donor/ acceptor interfaces, such as light emitting diodes and photodetectors. Our findings can be summarized by two points. First, devices with donor molecules face-on to the acceptor interface have a higher charge transfer state energy and less non-radiative recombination, resulting in larger open-circuit voltages and higher radiative efficiencies. Second, devices with donor molecules edge-on to the acceptor interface are more efficient at charge generation, attributed to smaller electronic coupling between the charge transfer states and the ground state, and lower activation energy for charge generation.
Y1  - 2017
U6  - https://doi.org/10.1038/s41467-017-00107-4
SN  - 2041-1723
VL  - 8
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Dommain, René
A1  - Andama, Morgan
A1  - McDonough, Molly M.
A1  - Prado, Natalia A.
A1  - Goldhammer, Tobias
A1  - Potts, Richard
A1  - Maldonado, Jesús E.
A1  - Nkurunungi, John Bosco
A1  - Campana, Michael G.
T1  - The Challenges of Reconstructing Tropical Biodiversity With Sedimentary Ancient DNA
BT  - A 2200-Year-Long Metagenomic Record From Bwindi Impenetrable Forest, Uganda
JF  - Frontiers in Ecology and Evolution
N2  - Sedimentary ancient DNA has been proposed as a key methodology for reconstructing biodiversity over time. Yet, despite the concentration of Earth’s biodiversity in the tropics, this method has rarely been applied in this region. Moreover, the taphonomy of sedimentary DNA, especially in tropical environments, is poorly understood. This study elucidates challenges and opportunities of sedimentary ancient DNA approaches for reconstructing tropical biodiversity. We present shotgun-sequenced metagenomic profiles and DNA degradation patterns from multiple sediment cores from Mubwindi Swamp, located in Bwindi Impenetrable Forest (Uganda), one of the most diverse forests in Africa. We describe the taxonomic composition of the sediments covering the past 2200 years and compare the sedimentary DNA data with a comprehensive set of environmental and sedimentological parameters to unravel the conditions of DNA degradation. Consistent with the preservation of authentic ancient DNA in tropical swamp sediments, DNA concentration and mean fragment length declined exponentially with age and depth, while terminal deamination increased with age. DNA preservation patterns cannot be explained by any environmental parameter alone, but age seems to be the primary driver of DNA degradation in the swamp. Besides degradation, the presence of living microbial communities in the sediment also affects DNA quantity. Critically, 92.3% of our metagenomic data of a total 81.8 million unique, merged reads cannot be taxonomically identified due to the absence of genomic references in public databases. Of the remaining 7.7%, most of the data (93.0%) derive from Bacteria and Archaea, whereas only 0–5.8% are from Metazoa and 0–6.9% from Viridiplantae, in part due to unbalanced taxa representation in the reference data. The plant DNA record at ordinal level agrees well with local pollen data but resolves less diversity. Our animal DNA record reveals the presence of 41 native taxa (16 orders) including Afrotheria, Carnivora, and Ruminantia at Bwindi during the past 2200 years. Overall, we observe no decline in taxonomic richness with increasing age suggesting that several-thousand-year-old information on past biodiversity can be retrieved from tropical sediments. However, comprehensive genomic surveys of tropical biota need prioritization for sedimentary DNA to be a viable methodology for future tropical biodiversity studies.
KW  - sedimentary ancient DNA
KW  - tropical biodiversity
KW  - DNA preservation
KW  - sediment
KW  - tropical swamp
KW  - shotgun sequencing
KW  - metagenomic analysis
Y1  - 2019
U6  - https://doi.org/10.3389/fevo.2020.00218
SN  - 2296-701X
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wacker, Alexander
A1  - Piepho, Maike
A1  - Harwood, John L.
A1  - Guschina, Irina A.
A1  - Arts, Michael T.
T1  - Light-Induced Changes in Fatty Acid Profiles of Specific Lipid Classes in Several Freshwater Phytoplankton Species
JF  - Frontiers in plant science : FPLS
N2  - We tested the influence of two light intensities [40 and 300 μmol PAR / (m2s)] on the fatty acid composition of three distinct lipid classes in four freshwater phytoplankton species. We chose species of different taxonomic classes in order to detect potentially similar reaction characteristics that might also be present in natural phytoplankton communities. From samples of the bacillariophyte Asterionella formosa, the chrysophyte Chromulina sp., the cryptophyte Cryptomonas ovata and the zygnematophyte Cosmarium botrytis we first separated glycolipids (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol), phospholipids (phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, and phosphatidylserine) as well as non-polar lipids (triacylglycerols), before analyzing the fatty acid composition of each lipid class. High variation in the fatty acid composition existed among different species. Individual fatty acid compositions differed in their reaction to changing light intensities in the four species. Although no generalizations could be made for species across taxonomic classes, individual species showed clear but small responses in their ecologically-relevant omega-3 and omega-6 polyunsaturated fatty acids (PUFA) in terms of proportions and of per tissue carbon quotas. Knowledge on how lipids like fatty acids change with environmental or culture conditions is of great interest in ecological food web studies, aquaculture, and biotechnology, since algal lipids are the most important sources of omega-3 long-chain PUFA for aquatic and terrestrial consumers, including humans.
KW  - freshwater algae
KW  - light adaptation
KW  - lipid classes
KW  - fatty acid changes
Y1  - 2016
U6  - https://doi.org/10.3389/fpls.2016.00264
SN  - 1664-462X
VL  - 7
SP  - 1
EP  - 13
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - GEN
A1  - Wacker, Alexander
A1  - Piepho, Maike
A1  - Harwood, John L.
A1  - Guschina, Irina A.
A1  - Arts, Michael T.
T1  - Light-Induced Changes in Fatty Acid Profiles of Specific Lipid Classes in Several Freshwater Phytoplankton Species
N2  - We tested the influence of two light intensities [40 and 300 μmol PAR / (m2s)] on the fatty acid composition of three distinct lipid classes in four freshwater phytoplankton species. We chose species of different taxonomic classes in order to detect potentially similar reaction characteristics that might also be present in natural phytoplankton communities. From samples of the bacillariophyte Asterionella formosa, the chrysophyte Chromulina sp., the cryptophyte Cryptomonas ovata and the zygnematophyte Cosmarium botrytis we first separated glycolipids (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol), phospholipids (phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol, and phosphatidylserine) as well as non-polar lipids (triacylglycerols), before analyzing the fatty acid composition of each lipid class. High variation in the fatty acid composition existed among different species. Individual fatty acid compositions differed in their reaction to changing light intensities in the four species. Although no generalizations could be made for species across taxonomic classes, individual species showed clear but small responses in their ecologically-relevant omega-3 and omega-6 polyunsaturated fatty acids (PUFA) in terms of proportions and of per tissue carbon quotas. Knowledge on how lipids like fatty acids change with environmental or culture conditions is of great interest in ecological food web studies, aquaculture, and biotechnology, since algal lipids are the most important sources of omega-3 long-chain PUFA for aquatic and terrestrial consumers, including humans.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 223 
KW  - fatty acid changes
KW  - freshwater algae
KW  - light adaptation
KW  - lipid classes
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-90682
SP  - 1
EP  - 13
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Andersson, T.
A1  - Anguner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arrieta, M.
A1  - Aubert, Pierre
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Barnard, Michelle
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Blackwell, R.
A1  - Böttcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bonnefoy, S.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Buechele, M.
A1  - Bulik, Tomasz
A1  - Capasso, M.
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Cerruti, M.
A1  - Chakraborty, N.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chevalier, J.
A1  - Coffaro, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Condon, B.
A1  - Conrad, Jan
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Decock, J.
A1  - Degrange, B.
A1  - Deil, C.
A1  - Devin, J.
A1  - de Wilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Funk, S.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, Tim Lukas
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Iwasaki, H.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jingo, M.
A1  - Jogler, T.
A1  - Jouvin, L.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, M.
A1  - Kruger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, T.
A1  - Lorentz, M.
A1  - Liu, R.
A1  - Lopez-Coto, R.
A1  - Lypova, I.
A1  - Marandon, V.
A1  - Marcowith, A.
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Mora, K.
A1  - Moulin, E.
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, M.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Perennes, C.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poon, H.
A1  - Prokhorov, D.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Richter, S.
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Saito, S.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, A.
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schussler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Settimo, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shilon, I.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Takahashi, T.
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tibaldo, L.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywucka, N.
T1  - Measurement of the EBL spectral energy distribution using the VHE gamma-ray spectra of HESS blazars
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Very high-energy gamma rays (VHE, E greater than or similar to 100 GeV) propagating over cosmological distances can interact with the low-energy photons of the extragalactic background light (EBL) and produce electron-positron pairs. The transparency of the Universe to VHE gamma rays is then directly related to the spectral energy distribution (SED) of the EBL. The observation of features in the VHE energy spectra of extragalactic sources allows the EBL to be measured, which otherwise is very difficult. An EBL model-independent measurement of the EBL SED with the H.E.S.S. array of Cherenkov telescopes is presented. It was obtained by extracting the EBL absorption signal from the reanalysis of high-quality spectra of blazars. From H.E.S.S. data alone the EBL signature is detected at a significance of 9.5 sigma, and the intensity of the EBL obtained in different spectral bands is presented together with the associated gamma-ray horizon.
KW  - gamma rays: galaxies
KW  - BL Lacertae objects: general
KW  - cosmic background radiation
KW  - infrared: diffuse background
Y1  - 2017
U6  - https://doi.org/10.1051/0004-6361/201731200
SN  - 1432-0746
VL  - 606
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Boettcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, C.
A1  - deWilt, P.
A1  - Djannati-Ataï, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Espigat, P.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Feinstein, F.
A1  - Fernandesl, M. V.
A1  - Fernandez, D.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, D.
A1  - Haeffner, S.
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Jacholkowska, A.
A1  - Jahn, C.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, F.
A1  - Jung-Richardt, I.
A1  - Kastendieckl, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Krayzel, F.
A1  - Krueger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Lohse, T.
A1  - Lopatin, A.
A1  - Lu, C. -C.
A1  - Lui, R.
A1  - Marandon, V.
A1  - Marcowith, A.
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - Meintjes, P. J.
A1  - Menzler, U.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, E.
A1  - Murach, T.
A1  - de Naurois, M.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Oettl, S.
A1  - Ohm, S.
A1  - de Ona Wilhelmi, E.
A1  - Opitz, B.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, H.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reichardt, I.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, A.
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schuessler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seyffert, A. S.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Valerius, K.
A1  - van der Walt, J.
A1  - van Eldik, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - Weidinger, M.
A1  - Weitzel, Q.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Zywucka, N.
T1  - Discovery of variable VHE gamma-ray emission from the binary system 1FGL J1018.6-5856
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Re-observations with the HESS telescope array of the very high-energy (VHE) source HESS J1018-589A that is coincident with the Fermi-LAT gamma-ray binary 1FGL J1018.6-5856 have resulted in a source detection significance of more than 9 sigma and the detection of variability (chi(2)/nu of 238.3/155) in the emitted gamma-ray flux. This variability confirms the association of HESS J1018-589A with the high-energy gamma-ray binary detected Fermi-LAT and also confirms the point-like source as a new VHE binary system. The spectrum of HESS J1018-589A is best fit with a power-law function with photon index Gamma = 2.20 +/- 0.14(stat) +/- 0.2(sys). Emission is detected up to similar to 20 TeV. The mean differential flux level is (2.9 +/- 0.4) x 10(-13) TeV-1 cm(-2) s(-1) at 1 TeV, equivalent to similar to 1% of the flux from the Crab Nebula at the same energy. Variability is clearly detected the night-by-night light curve. When folded on the orbital period of 16.58 days, the rebinned light curve peaks in phase with the observed X-ray high-energy phaseograms. The fit of the HESS phaseogram to a constant flux provides evidence of periodicity at the level of N-sigma > 3 sigma. The of the VHE phaseogram and measured spectrum suggest a low-inclination, low-eccentricity system with a modest impact from VHE gamma-ray due to pair production (tau less than or similar to 1 at 300 GeV).
KW  - gamma rays: stars
KW  - stars: individual: 1FGL J1018.6-5856
KW  - radiation mechanisms: non-thermal
KW  - acceleration of particles
KW  - X-rays: binaries
Y1  - 2015
U6  - https://doi.org/10.1051/0004-6361/201525699
SN  - 0004-6361
SN  - 1432-0746
VL  - 577
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Boettcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, C.
A1  - deWilt, P.
A1  - Djannati-Ata, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J-P.
A1  - Espigat, P.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Feinstein, F.
A1  - Fernandes, M. V.
A1  - Fernandez, D.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Goyal, A.
A1  - Grondin, M-H.
A1  - Grudzinska, M.
A1  - Hadasch, D.
A1  - Haeffner, S.
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, F.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Krayzel, F.
A1  - Krueger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J-P.
A1  - Lohse, T.
A1  - Lopatin, A.
A1  - Lu, C-C.
A1  - Lui, R.
A1  - Marandon, V.
A1  - Marcowith, A.
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - Meintjes, P. J.
A1  - Menzler, U.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, E.
A1  - Murach, T.
A1  - de Naurois, M.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Oettl, S.
A1  - Ohm, S.
A1  - Opitz, B.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P-O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, H.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reichardt, I.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, A.
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schuessler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seyffert, A. S.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J-P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tuffs, R.
A1  - Valerius, K.
A1  - van der Walt, J.
A1  - van Eldik, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - Weidinger, M.
A1  - Weitzel, Q.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Zywucka, N.
T1  - Acceleration of petaelectronvolt protons in the Galactic Centre
JF  - Nature : the international weekly journal of science
N2  - Galactic cosmic rays reach energies of at least a few petaelectronvolts (of the order of 1015 electronvolts). This implies that our Galaxy contains petaelectronvolt accelerators (‘PeVatrons’), but all proposed models of Galactic cosmic-ray accelerators encounter difficulties at exactly these energies. Dozens of Galactic accelerators capable of accelerating particles to energies of tens of teraelectronvolts (of the order of 1013 electronvolts) were inferred from recent &#947;-ray observations3. However, none of the currently known accelerators—not even the handful of shell-type supernova remnants commonly believed to supply most Galactic cosmic rays—has shown the characteristic tracers of petaelectronvolt particles, namely, power-law spectra of &#947;-rays extending without a cut-off or a spectral break to tens of teraelectronvolts4. Here we report deep &#947;-ray observations with arcminute angular resolution of the region surrounding the Galactic Centre, which show the expected tracer of the presence of petaelectronvolt protons within the central 10 parsecs of the Galaxy. We propose that the supermassive black hole Sagittarius A* is linked to this PeVatron. Sagittarius A* went through active phases in the past, as demonstrated by X-ray outbursts5and an outflow from the Galactic Centre6. Although its current rate of particle acceleration is not sufficient to provide a substantial contribution to Galactic cosmic rays, Sagittarius A* could have plausibly been more active over the last 106–107 years, and therefore should be considered as a viable alternative to supernova remnants as a source of petaelectronvolt Galactic cosmic rays.
Y1  - 2016
U6  - https://doi.org/10.1038/nature17147
SN  - 0028-0836
SN  - 1476-4687
VL  - 531
SP  - 476
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Springer, Mark S.
A1  - Signore, Anthony V.
A1  - Paijmans, Johanna L. A.
A1  - Velez-Juarbe, Jorge
A1  - Domning, Daryl P.
A1  - Bauer, Cameron E.
A1  - He, Kai
A1  - Crerar, Lorelei
A1  - Campos, Paula F.
A1  - Murphy, William J.
A1  - Meredith, Robert W.
A1  - Gatesy, John
A1  - Willerslev, Eske
A1  - MacPhee, Ross D. E.
A1  - Hofreiter, Michael
A1  - Campbell, Kevin L.
T1  - Interordinal gene capture, the phylogenetic position of Steller's sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia
JF  - Molecular phylogenetics and evolution
N2  - The recently extinct (ca. 1768) Steller's sea cow (Hydrodamalis gigas) was a large, edentulous North Pacific sirenian. The phylogenetic affinities of this taxon to other members of this clade, living and extinct, are uncertain based on previous morphological and molecular studies. We employed hybridization capture methods and second generation sequencing technology to obtain >30 kb of exon sequences from 26 nuclear genes for both H. gigas and Dugong dugon. We also obtained complete coding sequences for the tooth-related enamelin (ENAM) gene. Hybridization probes designed using dugong and manatee sequences were both highly effective in retrieving sequences from H. gigas (mean = 98.8% coverage), as were more divergent probes for regions of ENAM (99.0% coverage) that were designed exclusively from a proboscidean (African elephant) and a hyracoid (Cape hyrax). New sequences were combined with available sequences for representatives of all other afrotherian orders. We also expanded a previously published morphological matrix for living and fossil Sirenia by adding both new taxa and nine new postcranial characters. Maximum likelihood and parsimony analyses of the molecular data provide robust support for an association of H. gigas and D. dugon to the exclusion of living trichechids (manatees). Parsimony analyses of the morphological data also support the inclusion of H. gigas in Dugongidae with D. dugon and fossil dugongids. Timetree analyses based on calibration density approaches with hard- and soft-bounded constraints suggest that H. gigas and D. dugon diverged in the Oligocene and that crown sirenians last shared a common ancestor in the Eocene. The coding sequence for the ENAM gene in H. gigas does not contain frameshift mutations or stop codons, but there is a transversion mutation (AG to CG) in the acceptor splice site of intron 2. This disruption in the edentulous Steller's sea cow is consistent with previous studies that have documented inactivating mutations in tooth-specific loci of a variety of edentulous and enamelless vertebrates including birds, turtles, aardvarks, pangolins, xenarthrans, and baleen whales. Further, branch-site dN/dS analyses provide evidence for positive selection in ENAM on the stem dugongid branch where extensive tooth reduction occurred, followed by neutral evolution on the Hydrodamalis branch. Finally, we present a synthetic evolutionary tree for living and fossil sirenians showing several key innovations in the history of this clade including character state changes that parallel those that occurred in the evolutionary history of cetaceans. (C) 2015 Elsevier Inc. All rights reserved.
Y1  - 2015
U6  - https://doi.org/10.1016/j.ympev.2015.05.022
SN  - 1055-7903
SN  - 1095-9513
VL  - 91
SP  - 178
EP  - 193
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - McVey, Mark J.
A1  - Kim, Michael
A1  - Tabuchi, Arata
A1  - Srbely, Victoria
A1  - Japtok, Lukasz
A1  - Arenz, Christoph
A1  - Rotstein, Ori
A1  - Kleuser, Burkhard
A1  - Semple, John W.
A1  - Kuebler, Wolfgang M.
T1  - Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets
JF  - American journal of physiology : Lung cellular and molecular physiology
N2  - Pulmonary complications from stored blood products are the leading cause of mortality related to transfusion. Transfusion-related acute lung injury is mediated by antibodies or bioactive mediators, yet underlying mechanisms are incompletely understood. Sphingolipids such as ceramide regulate lung injury, and their composition changes as a function of time in stored blood. Here, we tested the hypothesis that aged platelets may induce lung injury via a sphingolipid-mediated mechanism. To assess this hypothesis, a two-hit mouse model was devised. Recipient mice were treated with 2 mg/kg intraperitoneal lipopolysaccharide (priming) 2 h before transfusion of 10 ml/kg stored (1-5 days) platelets treated with or without addition of acid sphingomyelinase inhibitor ARC39 or platelets from acid sphingomyelinase-deficient mice, which both reduce ceramide formation. Transfused mice were examined for signs of pulmonary neutrophil accumulation, endothelial barrier dysfunction, and histological evidence of lung injury. Sphingolipid profiles in stored platelets were analyzed by mass spectrophotometry. Transfusion of aged platelets into primed mice induced characteristic features of lung injury, which increased in severity as a function of storage time. Ceramide accumulated in platelets during storage, but this was attenuated by ARC39 or in acid sphingomyelinase-deficient platelets. Compared with wild-type platelets, transfusion of ARC39-treated or acid sphingomyelinase-deficient aged platelets alleviated lung injury. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase. Interventions targeting sphingolipid formation represent a promising strategy to increase the safety and longevity of stored blood products.
KW  - transfusion-related acute lung injury
KW  - ceramide
KW  - acid sphingomyelinase
KW  - platelets
KW  - storage
Y1  - 2017
U6  - https://doi.org/10.1152/ajplung.00317.2016
SN  - 1040-0605
SN  - 1522-1504
VL  - 312
IS  - 5
SP  - 625
EP  - 637
PB  - American Physiological Society
CY  - Bethesda
ER  - 
TY  - JOUR
A1  - Sicard, Adrien
A1  - Kappel, Christian
A1  - Lee, Young Wha
A1  - Wozniak, Natalia Joanna
A1  - Marona, Cindy
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Lenhard, Michael
T1  - Standing genetic variation in a tissue-specific enhancer underlies
selfing-syndrome evolution in Capsella
JF  - Proceedings of the National Academy of Sciences of the United States of America
N2  - Mating system shifts recurrently drive specific changes in organ dimensions. The shift in mating system from out-breeding to selfing is one of the most frequent evolutionary transitions in flowering plants and is often associated with an organ-specific reduction in flower size. However, the evolutionary paths along which polygenic traits, such as size, evolve are poorly understood. In particular, it is unclear how natural selection can specifically modulate the size of one organ despite the pleiotropic action of most known growth regulators. Here, we demonstrate that allelic variation in the intron of a general growth regulator contributed to the specific reduction of petal size after the transition to selfing in the genus Capsella. Variation within this intron affects an organ-specific enhancer that regulates the level of STERILE APETALA (SAP) protein in the developing petals. The resulting decrease in SAP activity leads to a shortening of the cell proliferation period and reduced number of petal cells. The absence of private polymorphisms at the causal region in the selfing species suggests that the small-petal allele was captured from standing genetic variation in the ancestral out-crossing population. Petal-size variation in the current out-crossing population indicates that several small-effect mutations have contributed to reduce petal-size. These data demonstrate how tissue-specific regulatory elements in pleiotropic genes contribute to organ-specific evolution. In addition, they provide a plausible evolutionary explanation for the rapid evolution of flower size after the out-breeding-to-selfing transition based on additive effects of segregating alleles.
KW  - morphological evolution
KW  - growth control
KW  - standing variation;
 organ-specific evolution
KW  - intronic cis-regulatory element
Y1  - 2016
U6  - https://doi.org/10.1073/pnas.1613394113
SN  - 0027-8424
VL  - 113
SP  - 13911
EP  - 13916
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Blaha, Karen A.
A1  - Pikovskij, Arkadij
A1  - Rosenblum, Michael
A1  - Clark, Matthew T.
A1  - Rusin, Craig G.
A1  - Hudson, John L.
T1  - Reconstruction of two-dimensional phase dynamics from experiments on coupled oscillators
JF  - Physical review : E, Statistical, nonlinear and soft matter physics
N2  - Phase models are a powerful method to quantify the coupled dynamics of nonlinear oscillators from measured data. We use two phase modeling methods to quantify the dynamics of pairs of coupled electrochemical oscillators, based on the phases of the two oscillators independently and the phase difference, respectively. We discuss the benefits of the two-dimensional approach relative to the one-dimensional approach using phase difference. We quantify the dependence of the coupling functions on the coupling magnitude and coupling time delay. We show differences in synchronization predictions of the two models using a toy model. We show that the two-dimensional approach reveals behavior not detected by the one-dimensional model in a driven experimental oscillator. This approach is broadly applicable to quantify interactions between nonlinear oscillators, especially where intrinsic oscillator sensitivity and coupling evolve with time.
Y1  - 2011
U6  - https://doi.org/10.1103/PhysRevE.84.046201
SN  - 1539-3755
VL  - 84
IS  - 4
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Toy, Virginia Gail
A1  - Sutherland, Rupert
A1  - Townend, John
A1  - Allen, Michael J.
A1  - Becroft, Leeza
A1  - Boles, Austin
A1  - Boulton, Carolyn
A1  - Carpenter, Brett
A1  - Cooper, Alan
A1  - Cox, Simon C.
A1  - Daube, Christopher
A1  - Faulkner, D. R.
A1  - Halfpenny, Angela
A1  - Kato, Naoki
A1  - Keys, Stephen
A1  - Kirilova, Martina
A1  - Kometani, Yusuke
A1  - Little, Timothy
A1  - Mariani, Elisabetta
A1  - Melosh, Benjamin
A1  - Menzies, Catriona D.
A1  - Morales, Luiz
A1  - Morgan, Chance
A1  - Mori, Hiroshi
A1  - Niemeijer, Andre
A1  - Norris, Richard
A1  - Prior, David
A1  - Sauer, Katrina
A1  - Schleicher, Anja Maria
A1  - Shigematsu, Norio
A1  - Teagle, Damon A. H.
A1  - Tobin, Harold
A1  - Valdez, Robert
A1  - Williams, Jack
A1  - Yeo, Samantha
A1  - Baratin, Laura-May
A1  - Barth, Nicolas
A1  - Benson, Adrian
A1  - Boese, Carolin
A1  - Célérier, Bernard
A1  - Chamberlain, Calum J.
A1  - Conze, Ronald
A1  - Coussens, Jamie
A1  - Craw, Lisa
A1  - Doan, Mai-Linh
A1  - Eccles, Jennifer
A1  - Grieve, Jason
A1  - Grochowski, Julia
A1  - Gulley, Anton
A1  - Howarth, Jamie
A1  - Jacobs, Katrina
A1  - Janku-Capova, Lucie
A1  - Jeppson, Tamara
A1  - Langridge, Robert
A1  - Mallyon, Deirdre
A1  - Marx, Ray
A1  - Massiot, Cécile
A1  - Mathewson, Loren
A1  - Moore, Josephine
A1  - Nishikawa, Osamu
A1  - Pooley, Brent
A1  - Pyne, Alex
A1  - Savage, Martha K.
A1  - Schmitt, Doug
A1  - Taylor-Offord, Sam
A1  - Upton, Phaedra
A1  - Weaver, Konrad C.
A1  - Wiersberg, Thomas
A1  - Zimmer, Martin
T1  - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand
JF  - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG
N2  - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled.
KW  - Alpine Fault
KW  - New Zealand
KW  - scientific drilling
KW  - mylonite
KW  - cataclasite
Y1  - 2017
U6  - https://doi.org/10.1080/00288306.2017.1375533
SN  - 0028-8306
SN  - 1175-8791
VL  - 60
IS  - 4
SP  - 497
EP  - 518
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - CHAP
A1  - Esveld, Selma van
A1  - Vries, Nardo de
A1  - Becchetti, Sibilla
A1  - Dopper, Sofia
A1  - Valkenburg, Willem van
A1  - Carlon, May Kristine Jonson
A1  - Yokoi, Kensuke
A1  - Gayed, John Maurice
A1  - Suyama, Hiroshi
A1  - Cross, Jeffrey Scott
A1  - Jin, Tonje
A1  - Xue, Wei
A1  - Bruillard, Éric
A1  - Steinbeck, Hendrik
A1  - Meinel, Christoph
A1  - Özdemir, Paker Doğu
A1  - Can Bayer, Burak
A1  - Mercan, Duygu
A1  - Buyurucu, Gamze
A1  - Haugsbakken, Halvdan
A1  - Hagelia, Marianne
A1  - Ebner, Martin
A1  - Edelsbrunner, Sarah
A1  - Hohla-Sejkora, Katharina
A1  - Lipp, Silvia
A1  - Schön, Sandra
A1  - Xiaoxiao, Wang
A1  - Shuangshuang, Guo
A1  - Morales-Chan, Miguel
A1  - Amado-Salvatierra, Héctor R.
A1  - Hernández-Rizzardini, Rocael
A1  - Egloffstein, Marc
A1  - Hünemohr, Holger
A1  - Ifenthaler, Dirk
A1  - Dixon, Fred
A1  - Trabucchi, Stefania
A1  - Khaneboubi, Mehdi
A1  - Giannatelli, Ada
A1  - Tomasini, Alessandra
A1  - Staubitz, Thomas
A1  - Serth, Sebastian
A1  - Thomas, Max
A1  - Koschutnig-Ebner, Markus
A1  - Rampelt, Florian
A1  - Stetten, Alexander von
A1  - Wittke, Andreas
A1  - Theeraroungchaisri, Anuchai
A1  - Thammetar, Thapanee
A1  - Duangchinda, Vorasuang
A1  - Khlaisang, Jintavee
A1  - Mair, Bettina
A1  - Steinkellner, Iris
A1  - Stojcevic, Ivana
A1  - Zwiauer, Charlotte
A1  - Thirouard, Maria
A1  - Villèsbrunne, Marie de la
A1  - Bernaert, Oliver
A1  - Nohr, Magnus
A1  - Alario Hoyos, Carlos
A1  - Delgado Kloos, Carlos
A1  - Kiendl, Doris
A1  - Terzieva, Liliya
A1  - Concia, Francesca
A1  - Distler, Petr
A1  - Law, Gareth
A1  - Macerata, Elena
A1  - Mariani, Mario
A1  - Mossini, Eros
A1  - Negrin, Maddalena
A1  - Štrok, Marko
A1  - Neuböck, Kristina
A1  - Linschinger, Nadine
A1  - Lorenz, Anja
A1  - Bock, Stefanie
A1  - Schulte-Ostermann, Juleka
A1  - Moura Santos, Ana
A1  - Corti, Paola
A1  - Costa, Luis Felipe Coimbra
A1  - Utunen, Heini
A1  - Attias, Melissa
A1  - Tokar, Anna
A1  - Kennedy, Eileen
A1  - Laurillard, Diana
A1  - Zeitoun, Samar
A1  - Wasilewski, Julie
A1  - Shlaka, Souhad
A1  - Ouahib, Sara
A1  - Berrada, Khalid
A1  - Dietz, Michael
A1  - Roth, Dennis
ED  - Meinel, Christoph
ED  - Schweiger, Stefanie
ED  - Staubitz, Thomas
ED  - Conrad, Robert
ED  - Alario Hoyos, Carlos
ED  - Ebner, Martin
ED  - Sancassani, Susanna
ED  - Żur, Agnieszka
ED  - Friedl, Christian
ED  - Halawa, Sherif
ED  - Gamage, Dilrukshi
ED  - Cross, Jeffrey
ED  - Jonson Carlon, May Kristine
ED  - Deville, Yves
ED  - Gaebel, Michael
ED  - Delgado Kloos, Carlos
ED  - von Schmieden, Karen
T1  - EMOOCs 2023
BT  - Post-Covid Prospects for Massive Open Online Courses - Boost or Backlash?
N2  - From June 14 to June 16, 2023, Hasso Plattner Institute, Potsdam, hosted the eighth European MOOC Stakeholder Summit (EMOOCs 2023).

The pandemic is fortunately over. It has once again shown how important digital education is. How well-prepared a country was could be seen in our schools, universities, and companies. In different countries, the problems manifested themselves differently. The measures and approaches to solving the problems varied accordingly. Digital education, whether micro-credentials, MOOCs, blended learning formats, or other e-learning tools, received a major boost. 

EMOOCs 2023 focusses on the effects of this emergency situation. How has it affected the development and delivery of MOOCs and other e-learning offerings all over Europe? Which projects can serve as models for successful digital learning and teaching? Which roles can MOOCs and micro-credentials bear in the current business transformation? Is there a backlash to the routine we knew from pre-Corona times? Or have many things become firmly established in the meantime, e.g. remote work, hybrid conferences, etc.? 

Furthermore, EMOOCs 2023 has a closer look at the development and formalization of digital learning. Micro-credentials are just the starting point. Further steps in this direction would be complete online study programs or full online universities.

Another main topic is the networking of learning offers and the standardization of formats and metadata. Examples of fruitful cooperations are the MOOChub, the European MOOC Consortium, and  the Common Micro-Credential Framework.

The learnings, derived from practical experience and research, are explored in EMOOCs 2023 in four tracks and additional workshops, covering various aspects of this field. In this publication, we present papers from the conference’s Research & Experience Track, the Business Track and the International Track.
N2  - Vom 14. bis 16. Juni 2023 fand am Hasso-Plattner-Institut in Potsdam der achte European MOOC Stakeholder Summit (EMOOCs 2023) statt.

Die Pandemie ist zum Glück vorbei. Sie hat einmal mehr gezeigt, wie wichtig digitale Bildung ist. Wie gut ein Land darauf vorbereitet war, zeigte sich in unseren Schulen, Universitäten und Unternehmen. In den verschiedenen Ländern haben sich die Probleme unterschiedlich manifestiert. Entsprechend unterschiedlich waren auch die Maßnahmen und Lösungsansätze. Die digitale Bildung, ob Micro-Credentials, MOOCs, Blended-Learning-Formate oder andere E-Learning-Tools, erhielt einen großen Schub.

EMOOCs 2023 befasst sich mit den Auswirkungen dieser Notsituation. Wie hat sie die Entwicklung und Bereitstellung von MOOCs und anderen E-Learning-Angeboten in ganz Europa beeinflusst? Welche Projekte können als Modelle für erfolgreiches digitales Lernen und Lehren dienen? Welche Rolle können MOOCs und Micro-Credentials bei der aktuellen Transformation der Wirtschaft spielen? Gibt es eine Rückbesinnung auf die Routine, die wir aus der Zeit vor Corona kennen? Oder haben sich viele Dinge inzwischen fest etabliert, z.B. Remote Work, hybride Konferenzen, etc.

Darüber hinaus wirft EMOOCs 2023 einen genaueren Blick auf die Entwicklung und Formalisierung des digitalen Lernens. Microcredentials sind nur der Anfang. Weitere Schritte in diese Richtung wären komplette Online-Studiengänge oder vollständige Online-Universitäten.

Ein weiteres Schwerpunktthema ist die Vernetzung von Lernangeboten und die Standardisierung von Formaten und Metadaten. Beispiele für fruchtbare Kooperationen sind der MOOChub, das European MOOC Consortium und das Common Micro-Credential Framework.

Die aus der Praxis und der Forschung gewonnenen Erkenntnisse werden auf der EMOOCs 2023 in vier Tracks und zusätzlichen Workshops zu verschiedenen Aspekten des Themas vertieft. In dieser Publikation stellen wir Beiträge aus dem Research & Experience Track,  dem Business Track und dem International Track vor.
KW  - MOOC
KW  - digital education
KW  - e-learning
KW  - online course design
KW  - online course creation
KW  - micro-credential
KW  - micro degree
KW  - online teaching
KW  - MOOC
KW  - Onlinekurs
KW  - Digitale Bildung
KW  - Online-Lehre
KW  - Kursdesign
KW  - Onlinekurs-Produktion
KW  - Micro Degree
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-576450
ER  - 
TY  - JOUR
A1  - Sicard, Adrien
A1  - Thamm, Anna
A1  - Marona, Cindy
A1  - Lee, Young Wha
A1  - Wahl, Vanessa
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Kappel, Christian
A1  - Lenhard, Michael
T1  - Repeated evolutionary changes of leaf morphology caused by mutations to a homeobox gene
JF  - Current biology
N2  - Elucidating the genetic basis of morphological changes in evolution remains a major challenge in biology [1-3]. Repeated independent trait changes are of particular interest because they can indicate adaptation in different lineages or genetic and developmental constraints on generating morphological variation [4-6]. In animals, changes to "hot spot" genes with minimal pleiotropy and large phenotypic effects underlie many cases of repeated morphological transitions [4-8]. By contrast, only few such genes have been identified from plants [8-11], limiting cross-kingdom comparisons of the principles of morphological evolution. Here, we demonstrate that the REDUCED COMPLEXITY (RCO) locus [12] underlies more than one naturally evolved change in leaf shape in the Brassicaceae. We show that the difference in leaf margin dissection between the sister species Capsella rubella and Capsella grandiflora is caused by cis-regulatory variation in the homeobox gene RCO-A, which alters its activity in the developing lobes of the leaf. Population genetic analyses in the ancestral C. grandiflora indicate that the more-active C. rubella haplotype is derived from a now rare or lost C. grandiflora haplotype via additional mutations. In Arabidopsis thaliana, the deletion of the RCO-A and RCO-B genes has contributed to its evolutionarily derived smooth leaf margin [12], suggesting the RCO locus as a candidate for an evolutionary hot spot. We also find that temperature-responsive expression of RCO-A can explain the phenotypic plasticity of leaf shape to ambient temperature in Capsella, suggesting a molecular basis for the well-known negative correlation between temperature and leaf margin dissection.
Y1  - 2014
U6  - https://doi.org/10.1016/j.cub.2014.06.061
SN  - 0960-9822
SN  - 1879-0445
VL  - 24
IS  - 16
SP  - 1880
EP  - 1886
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Sicard, Adrien
A1  - Kappel, Christian
A1  - Josephs, Emily B.
A1  - Lee, Young Wha
A1  - Marona, Cindy
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Lenhard, Michael
T1  - Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella
JF  - Nature Communications
N2  - In the Bateson-Dobzhansky-Muller model of genetic incompatibilities post-zygotic gene-flow barriers arise by fixation of novel alleles at interacting loci in separated populations. Many such incompatibilities are polymorphic in plants, implying an important role for genetic drift or balancing selection in their origin and evolution. Here we show that NPR1 and RPP5 loci cause a genetic incompatibility between the incipient species Capsella grandiflora and C. rubella, and the more distantly related C. rubella and C. orientalis. The incompatible RPP5 allele results from a mutation in C. rubella, while the incompatible NPR1 allele is frequent in the ancestral C. grandiflora. Compatible and incompatible NPR1 haplotypes are maintained by balancing selection in C. grandiflora, and were divergently sorted into the derived C. rubella and C. orientalis. Thus, by maintaining differentiated alleles at high frequencies, balancing selection on ancestral polymorphisms can facilitate establishing gene-flow barriers between derived populations through lineage sorting of the alternative alleles.
Y1  - 2015
U6  - https://doi.org/10.1038/ncomms8960
SN  - 2041-1723
VL  - 6
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Sicard, Adrien
A1  - Kappel, Christian
A1  - Josephs, Emily B.
A1  - Wha Lee, Young
A1  - Marona, Cindy
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Lenhard, Michael
T1  - Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella
N2  - In the Bateson–Dobzhansky–Muller model of genetic incompatibilities post-zygotic gene-flow barriers arise by fixation of novel alleles at interacting loci in separated populations. Many such incompatibilities are polymorphic in plants, implying an important role for genetic drift or balancing selection in their origin and evolution. Here we show that NPR1 and RPP5 loci cause a genetic incompatibility between the incipient species Capsella grandiflora and C. rubella, and the more distantly related C. rubella and C. orientalis. The incompatible RPP5 allele results from a mutation in C. rubella, while the incompatible NPR1 allele is frequent in the ancestral C. grandiflora. Compatible and incompatible NPR1 haplotypes are maintained by balancing selection in C. grandiflora, and were divergently sorted into the derived C. rubella and C. orientalis. Thus, by maintaining differentiated alleles at high frequencies, balancing selection on ancestral polymorphisms can facilitate establishing gene-flow barriers between derived populations through lineage sorting of the alternative alleles.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 231 
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-93568
ER  - 
TY  - JOUR
A1  - Sicard, Adrien
A1  - Kappel, Christian
A1  - Josephs, Emily B.
A1  - Wha Lee, Young
A1  - Marona, Cindy
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Lenhard, Michael
T1  - Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella
JF  - Nature Communications
N2  - In the Bateson–Dobzhansky–Muller model of genetic incompatibilities post-zygotic gene-flow
barriers arise by fixation of novel alleles at interacting loci in separated populations. Many such incompatibilities are polymorphic in plants, implying an important role for genetic drift or balancing selection in their origin and evolution. Here we show that NPR1 and RPP5 loci cause a genetic incompatibility between the incipient species Capsella grandiflora and C. rubella, and the more distantly related C. rubella and C. orientalis. The incompatible RPP5 allele results from a mutation in C. rubella, while the incompatible NPR1 allele is frequent in the ancestral C. grandiflora. Compatible and incompatible NPR1 haplotypes are maintained by balancing selection in C. grandiflora, and were divergently sorted into the derived C. rubella and
C. orientalis. Thus, by maintaining differentiated alleles at high frequencies, balancing selection
on ancestral polymorphisms can facilitate establishing gene-flow barriers between derived populations through lineage sorting of the alternative alleles.
Y1  - 2015
U6  - https://doi.org/10.1038/ncomms8960
SN  - 2041-1723
VL  - 6
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - BOOK
A1  - Weiß, Norman
A1  - Mürbe, Ulrike
A1  - Zichy, Michael
A1  - Jeutner, Valentin
A1  - Heinrichs, Bert
A1  - Risse, Verena
A1  - Brunozzi, Philippe
A1  - Gerson, Oliver Harry
A1  - Martinsen, Franziska
A1  - Link, Jochen
A1  - Pollmann, Arnd
A1  - Wildfeuer, Dennis
A1  - Laukötter, Sebastian
A1  - John, Emanuel
A1  - Baranzke, Heike
A1  - Schoellner, Karsten
A1  - Schües, Christina
A1  - Koppe, David
ED  - Mürbe, Ulrike
ED  - Weiß, Norman
T1  - Philosophie der Menschenrechte in Theorie und Praxis
BT  - Über Aufgaben und Grenzen praktischer Philosophie vor dem Hintergrund menschen- und völkerrechtlicher Wirklichkeiten
T3  - Studien zu Grund- und Menschenrechten
N2  - In welcher Beziehung steht die praktische Philosophie zur Wirklichkeit der Menschenrechtsfragen in Recht und Politik? Wie kann und soll sie sich ihrem komplexen Gegenstand nähern? Inwieweit kommt ihr die Aufgabe zu, politisches Geschehen konkret zu kommentieren und Vorschläge für die Implementierung menschenrechtstheoretischer Annahmen zu machen? Wie lässt sie sich als anwendungsorientierte Disziplin denken, die jenseits reiner Begründungsdiskurse einen Beitrag zur globalen Stärkung der Menschenrechtsidee leistet?

Der vorliegende Sammelband geht diesen und verwandten Fragen in acht Beiträgen mit jeweils einem Kommentar nach und regt damit zum Nachdenken über das Selbstverständnis zeitgenössischer Menschenrechtsphilosophie an.
T3  - Studien zu Grund- und Menschenrechten - 18 
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-402732
SN  - 978-3-86956-419-7
SN  - 1435-9154
SN  - 2568-6348
EP  - 18
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - JOUR
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
JF  - Kidney international : official journal of the International Society of Nephrology
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - https://doi.org/10.1016/j.kint.2020.09.030
SN  - 0085-2538
SN  - 1523-1755
VL  - 99
IS  - 4
SP  - 926
EP  - 939
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Lepetit, Petra
A1  - Viereck, Lothar
A1  - Piper, John D. A.
A1  - Sudo, Masafumi
A1  - Gurel, Ali
A1  - Copuroglu, Ibrahim
A1  - Gruber, Manuela
A1  - Mayer, Bernhard
A1  - Koch, Michael
A1  - Tatar, Orhan
A1  - Gursoy, Halil
T1  - Ar-40/Ar-39 dating of ignimbrites and plinian air-fall layers from Cappadocia, Central Turkey: Implications to chronostratigraphic and Eastern Mediterranean palaeoenvironmental record
JF  - Chemie der Erde : interdisciplinary journal for chemical problems of the geo-sciences and geo-ecology
N2  - Magmatism forming the Central Anatolian Volcanic Province of Cappadocia, central Turkey, records the last phase of Neotethyan subduction after similar to 11 Ma. Thirteen large calc-alkaline ignimbrite sheets form marker bands within the volcano-sedimentary succession (the Urgup Formation) and provide a robust chronostratigraphy for paleoecologic evaluation of the interleaved paleosols. This paper evaluates the chronologic record in the context of the radiometric, magnetostratigraphic and lithostratigraphic controls. Previous inconsistencies relating primarily to K/Ar evidence were reason for the initiation of an integrated study which includes Ar-40/Ar-39 dating, palaeomagnetic and stratigraphic evidence. The newly determined Ar-40/Ar-39-ages (Lepetit, 2010) are in agreement with Ar/Ar and U/Pb data meanwhile published by Pauquette and Le Pennec (2012) and Aydar et al. (2012). The Ar-40/Ar-39-ages restrict the end of the Urgup Formation to the late Miocene. The paleosol sequence enclosed by the ignimbrites is thus restricted to the late Miocene, the most intense formation of pedogene calcretes correlating with the Messinian Salinity Crisis.
KW  - Ar-40/Ar-39 dating
KW  - Tephrostratigraphy
KW  - Neogene
KW  - Cappadocia
KW  - Turkey
Y1  - 2014
U6  - https://doi.org/10.1016/j.chemer.2014.05.001
SN  - 0009-2819
SN  - 1611-5864
VL  - 74
IS  - 3
SP  - 471
EP  - 488
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Rosenhahn, Axel
A1  - Finlay, John A.
A1  - Pettit, Michala E.
A1  - Ward, Andy
A1  - Wirges, Werner
A1  - Gerhard, Reimund
A1  - Callow, Maureen E.
A1  - Grunze, Michael
A1  - Callow, James A.
T1  - Zeta potential of motile spores of the green alga Ulva linza and the influence of electrostatic interactions on spore settlement and adhesion strength
N2  - The zeta potential of the motile spores of the green alga (seaweed) Ulva linza was quantified by video microscopy in combination with optical tweezers and determined to be -19.3ñ1.1 mV. The electrostatic component involved in the settlement and adhesion of spores was studied using electret surfaces consisting of PTFE and bearing different net charges. As the surface chemistry remains the same for differently charged surfaces, the experimental results isolate the influence of surface charge and thus electrostatic interactions. Ulva spores were demonstrated to have a reduced tendency to settle on negatively charged surfaces and when they did settle the adhesion strength of settled spores was lower than with neutral or positively charged surfaces. These observations can be ascribed to electrostatic interactions.
Y1  - 2009
UR  - http://biointerphases.org/
U6  - https://doi.org/10.1116/1.3110182
SN  - 1559-4106
ER  - 
TY  - THES
A1  - John, Cédric Michaël
T1  - Miocene climate as recorded on slope carbonates : examples from Malta (Central Mediterranean) and Northeastern Australia (Marion Plateau, ODP LEG 194)
N2  - Im Rahmen dieser Doktorarbeit wurden die Hangkarbonate von zwei miozänen heterozoischen Karbonatsystemen näher untersucht: die Malta Inselgruppe (zentrales Mittelmeer) und das Marion Plateau (Nordost Australien, ODP Leg 194). Die Auswirkungen der mittelmiozänen Abkühlung (Mi3), die auf 13.6 Ma datiert wird und starken Einfluß auf die Sauerstoffisotopenkurve hatte, in den oben genannten Flachwassersystemen stellten das Ziel dieser Arbeit dar. Dieses Abkühlungsereignis beeinflußte außerdem sehr stark die ozeanographischen und klimatischen Muster, die im weiteren Verlauf zum modernen Eishausklima führten. So steht insbesondere die Vereisung von Ostantarktika mit diesem Ereignis in Verbindung. Diese Arbeit untersucht den Einfluß dieses Ereignisses auf Flachwassersysteme, um vorliegende Untersuchungen in Tiefwassersystemen zu ergänzen und so zum globalen Verständnis des miozänen Klimawechsels beizutragen.  Die Profile auf der Maltainselgruppe wurden mit Hilfe von Kohlenstoff- und Sauerstoffisotopen Auswertungen im Gesamtgestein, Gesamtgesteinmineralogie, Tonmineralanalyse und organischer Geochemie untersucht. Durch einen Wechsel von karbonatischeren zu tonigeren Sedimenten beeinflußte das mittelmiozäne Abkühlungsereignis die Sedimentation in diesem Gebiet sehr stark. Weiterhin wurde beobachtet, daß jede Phase der antarktischen Vereisung, nicht nur das mittelmiozäne Hauptereignis, zu einem erhöhten terrigenen Eintrag in den Hangsedimenten der Maltainselgruppe führte. Akkumulationsraten zeigen, daß dieser erhöhte terrigene Eintrag den einzelnen Vereisungsperioden zusammenhängt und die karbonatischen Sedimente durch tonreiche Sedimente &ldquo;verunreinigt&rdquo; wurden. Das daraufhin entwickelte Modell erklärt diesen erhöhten terrigenen Eintrag mit einer nordwärtigen Verlagerung der innertropischen Konvergenzzone durch die Bildung von kalten, dichten Luftmassen, die zu verstärkten Niederschlägen in Nordafrika führten. Diese verstärkten Niederschläge (oder verstärkter afrikanischer Monsun) beeinflußten die kontinentale Verwitterung und den Eintrag, mit der Folge, daß verstärkt terrigene Sedimente im Bereich der Hangsedimente der Maltainselgruppe abgelagert wurden. Die tonreichen Intervalle weisen Ähnlichkeiten zu sapropelischen Ablagerungen auf, was mit Hilfe der Spektral analyse des Karbonatgehalts und der geochemischen Analyse des organischen Materials gezeigt wurde.   Auf dem Marion Plateau wurden die Sauerstoff- und Kohlenstoffisotopenkurven anhand von Foraminiferen der Gattung Cibicidoides spp. rekonstruiert. Der Karbonatgehalt wurde mit Hilfe einer chemischen Methode (Coulometer) ermittelt. Genauso wie die Sedimente der Maltainselgruppe beeinflußte das mittelmiozäne Abkühlungsereignis (Mi3) auch die Sedimente auf dem Marion Plateau. So kam es bei 13,8 Ma, in etwa zur Zeit der Vereisung von Ostantarktika, zu einem Abfall der Karbonatakkumulationsraten. Weiterhin traten Änderungen in der Zusammensetzung der Sedimente auf, so nehmen neritische Karbonatfragmente ab, der planktische Foraminiferengehalt nimmt zu und es wurden verstärkt Quarz und Glaukonit abgelagert. Ein überraschendes Ergebnis ist die Tatsache, daß der große N12-N14 Meeresspiegelabfall um 11,5 Ma die Akkumulationsraten der Karbonate auf dem Hang nicht beeinflußte. Dieses Ergebnis ist umso erstaunlicher, da Karbonatplattformen normalerweise sehr sensitiv auf Meeresspiegeländerungen reagieren. Der Grund, warum sich die Karbonatakkumulationsraten schon um 13,6 Ma (Mi3) und nicht erst um 11,5 Ma (N12-N14) verringerten, liegt in der Tatsache, daß die ozeanischen Strömungen die Karbonatsedimentation auf dem Hang des Marion Plateau schon im Miozän kontrollierten. Das mittelmiozäne Ereignis (Mi3) erhöhte die Stärke diese Strömungen und als eine Ursache wurde die Karbonatakkumulation auf den Hängen reduziert. Die Amplitude des N12-N14 Meeresspiegelabfalls liegt bei 90 m unter der Berücksichtigung der Sauerstoffisotopendaten aus der Tiefsee und Berechnungen des Meeresspiegels anhand des &ldquo;coastal onlaps&rdquo;, die während Leg 194 gemacht wurden. Die Isotopendaten dieser Arbeit weisen hingegen auf einen verringerten Meeresspiegelabfall von 70 m hin.  Als allgemeine Schlußfolgerung kann gesagt werden, daß der mittelmiozäne Klimaumschwung die Karbonatsysteme zumindest an den beiden untersuchten Lokalitäten beeinflußt hat. Allerdings waren die Auswirkungen sehr von den unterschiedlichen lokalen Gegebenheiten abhängig. Insbesondere wirkten sich die Anwesenheit einer Landmasse (Malta) und die Abwesenheit einer Barriere vor den Einflüssen des offenen Ozeans (Marion Plateau) stark auf die Ablagerung der Karbonate aus.
N2  - This study investigated the slope carbonates of two Miocene carbonate systems: the Maltese Islands (in the Central Mediterranean) and the Marion Plateau (Northeastern Australia, drilled during ODP Leg 194). The aim of the study was to trace the impact of the Miocene cooling steps (events Mi1-Mi6) in these carbonate systems, especially the Mi3 event, which took place around 13.6 Ma and deeply impacted the marine oxygen isotope record. This event also profoundly impacted oceanographic and climatic patterns, eventually leading to the establishment of the modern ice-house world. In particular, East Antarctica became ice covered at that period. The rational behind the present study was to investigate the impact that this event had on shallow water systems in order to complement the deep-sea record and hence acquire a more global perspective on Miocene climate change.  The Maltese Islands were investigated for trends in bulk-rock carbon and oxygen isotopes, as well as bulk-rock mineralogy, clay minerals analysis and organic geochemisty. Results showed that the mid Miocene cooling event deeply impacted sedimentation at that location by changing sedimentation from carbonate to clay-rich sediments. Moreover, it was discovered that each phase of Antarctic glaciation, not just the major mid Miocene event, resulted in higher terrigenous input on Malta. Mass accumulation rates revealed that this was linked to increased runoff during periods when Antarctica was glaciated, and thus that the carbonate sediments were &ldquo;diluted&rdquo; by clay-rich sediments. The model subsequently developed to explain this implies feedback from Antarctic glaciations creating cold, dense air masses that push the ITCZ Northward, thus increasing precipitation on the North African subcontinent. Increased precipitation (or stronger African monsoon) accelerated continental weathering and runoff, thus bringing more terrigenous sediment to the paleo-location of the slope sediments of Malta. Spectral analysis of carbonate content and organic matter geochemical analysis furthermore suggest that the clay-rich intervals are similar to sapropelic deposits.  On the Marion Plateau, trends in oxygen and carbon isotopes were obtained by measuring Cibicidoides spp foraminifers. Moreover, carbonate content was reconstructed using a chemical method (coulometer). Results show that the mid Miocene cooling step profoundly affected this system: a major drop in accumulation rates of carbonates occurs precisely at 13.8 Ma, around the time of the East Antarctic ice sheet formation. Moreover, sedimentation changes occurred at that time, carbonate fragments coming from neritic environments becoming less abundant, planktonic foraminifer content increasing and quartz and reworked glauconite being deposited. Conversely, a surprising result is that the major N12-N14 sea-level fall occurring around 11.5 Ma did not impact the accumulation of carbonates on the slope. This was unexpected since carbonate platform are very sensitive to sea-level changes. The model developed to explain that mass accumulation rates of carbonates diminished around 13.6 Ma (Mi3 Event) instead of 11.5 Ma (N12-N14 event), suggests that oceanic currents were controlling slope carbonate deposition on the Marion Plateau prior to the mid-Miocene, and that the mid Miocene event considerably increase their strength, hence reducing the amount of carbonate being deposited on slope sites. Moreover, by combining results from deep-sea oxygen isotopes with sea-level estimates based on coastal onlaps made during Leg 194, we constrain the amplitude of the N12-N14 sea-level fall to 90 meters. When integrating isotopic results from this study, this amplitude is lowered to 70 meters.  A general conclusion of this work is that the mid Miocene climatic shift did impact carbonate systems, at least at the two locations studied. However, the nature of this response was highly dependant on the regional settings, in particular the presence of land mass (Malta) and the absence of a barrier to shelter from the effects of open ocean (Marion Plateau).
KW  - mittleres Miozän
KW  - Klima
KW  - Sauerstoffisotope
KW  - Kohlenstoffisotope
KW  - Kontinentalrand
KW  - Tonmineralien
KW  - Karbonate
KW  - Malta
KW  - Mittelmeer
KW  - Australien
KW  - ODP Leg 194
KW  - middle Miocene
KW  - climate
KW  - oxygen isotopes
KW  - carbon isotopes
KW  - continental margins
KW  - clay mineral
KW  - carbonate systems
KW  - Malta
KW  - Meditteranean sea
KW  - Australia
Y1  - 2003
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-0000820
ER  - 
TY  - JOUR
A1  - John, Cedric Michael
A1  - Adatte, Thierry
A1  - Mutti, Maria
T1  - Regional trends in clay mineral fluxes to the Queensland margin and ties to middle Miocene global cooling
N2  - Three ODP sites located on the Marion Plateau, Northeast Australian margin, were investigated for clay mineral and bulk mineralogy changes through the early to middle Miocene. Kaolinite to smectite (K/S) ratios, as well as mass accumulation rates of clays, point to a marked decrease in accumulation of smectite associated with an increase in accumulation of kaolinite starting at similar to 15.6 Ma, followed by a, second increase in accumulation of kaolinite at similar to 13.2 Ma. Both of these increases are correlative to an increase in the calcite to detritus ratio. Comparison of our record with published precipitation proxies from continental Queensland indicates that increases in kaolinite did not correspond to more intense tropical-humid conditions, but instead to periods of greater aridity. Three mechanisms are explored to explain the temporal trends in clad, on the Marion Plateau: sea-level changes, changes in oceanic currents, and denudation of the Australian continent followed by reworking and eolian transport of clays. Though low mass accumulation rates of kaolinite are compatible with a possible contribution of eolian material after 14 Ma, when Australia became more arid, the lateral distribution of kaolinite along slope indicates mainly fluvial input for all clays and thus rules out this mechanism as well as oceanic current transport as the main controls behind clay accumulation on the plateau. We propose a model explaining the good correlation between long-term sea-level fall, decrease in smectite accumulation, increase in kaolinite accumulation and increase in carbonate input to the distal slope locations. We hypothesize that during low sea level and thus periods of drier continental climate in Queensland, early Miocene kaolinite-rich lacustrine deposits were being reworked, and that the progradation of the heterozoan carbonate platforms towards the basin center favored input of carbonate to the distal slope sites. The major find of our study is that increase kaolinite fluxes on the Queensland margin during the early and middle Miocene did not reflect the establishment of a tropical climate, and this stresses that care must be taken when reconstructing Australian climate based on deep-sea clay records alone.
Y1  - 2006
UR  - http://www.sciencedirect.com/science/journal/00310182
U6  - https://doi.org/10.1016/j.palaeo.2005.09.010
SN  - 0031-0182
ER  - 
TY  - JOUR
A1  - John, Cedric Michael
A1  - Karner, G. D.
A1  - Mutti, Maria
T1  - delta O-18 and Marion Plateau backstripping : Combining two approaches to constrain late middle Miocene eustatic amplitude
N2  - delta(18)O(benthic), values from Leg 194 Ocean Drilling Program Sites 1192 and 1195, (drilled on the Marion Plateau) were combined with deep-sea values to reconstruct the magnitude range of the late middle Miocene sea-level fall (13.6-11.4 Ma). In parallel, an estimate for the late middle Miocene sea-level fall was calculated from the stratigraphic relationship identified during Leg 194 and the structural relief of carbonate platforms that form the Marion Plateau. Corrections for thermal subsidence induced by Late Cretaceous rifting, flexural sediment loading, and sediment compaction were taken into account. The response of the lithosphere to sediment loading was considered for a range of effective elastic thicknesses (10 < T-e < 40 km). By overlapping the sea-level range of both the deep-sea isotopes and the results from the backstripping analysis, we demonstrate that the amplitude of the late middle Miocene sea-level fall was 45-68 m (56.5 +/- 11.5 m). Including an estimate for sea-level variation using the delta(18)O(benthic) results from the subtropical Marion Plateau, the range of sea-level fall is tightly constrained between 45 and 55 in (50.0 +/- 5.0 m). This result is the first precise quantitative estimate for the amplitude of the late middle Miocene eustatic fall that sidesteps the errors inherent in using benthic foraminifera assemblages to predict paleo-water depth. The estimate also includes an error analysis for the flexural response of the lithosphere to both water and sediment loads. Our result implies that the extent of ice buildup in the Miocene was larger than previously estimated, and conversely that the amount of cooling associated with this event was less important
Y1  - 2004
SN  - 0091-7613
ER  - 
TY  - JOUR
A1  - John, Cedric Michael
A1  - Mutti, Maria
T1  - Relative control of paleoceanography, climate, and eustasy over heterozoan carbonates : a perspective from slope sediments of the Marion Plateau (ODP LEG 194)
N2  - In this paper we explore the relative control of paleoceanography, eustasy, and water temperature over the evolution of a carbonate slope system deposited on the Marion Plateau (Northeastern Australia). Growth of several carbonate platforms started in the early Miocene on this plateau, and although they occurred in low-latitude subtropical waters they are composed mainly of heterozoan organisms. We investigated an upper to distal slope transect drilled during ODP Leg 194 and located close to the Northern Marion Platform. We reconstructed mass accumulation rates of carbonate as well as the evolution in the ratios of carbon and oxygen stable isotopes. Power spectrum analysis of the carbon isotope record revealed the existence of cycles with main frequencies centered around 409 Kyr and 1800 Kyr. We interpret the 409 Kyr cycle as being paced by changes in the eccentricity of the Earth orbit, and we suggest that the 1800 Kyr cycle could be linked to long-term eustatic changes. Finally, on the basis of the timing of changes in mass accumulation rates of carbonate we infer that the strength and direction of oceanic currents affected sedimentation on the Marion Plateau by shifting depocenters of slope sedimentation, a process probably further modulated by sea-level changes. We argue that the evolution and demise of the heterozoan carbonate systems present on the Marion Plateau were controlled mainly by the evolution of strong benthic currents, and that eustasy and water temperature alone did not account for the drowning of the platforms in the mid Miocene
Y1  - 2005
SN  - 1527-1404
ER  -