TY  - JOUR
A1  - Aichert, Ingrid
A1  - Staiger, Anja
A1  - Schulte-Mäter, Anne
A1  - Becker-Redding, Ulrike
A1  - Stahn, Corinna
A1  - Peschke, Claudia
A1  - Heide, Judith
A1  - Ott, Susan
A1  - Herrmann, Heike
A1  - Völsch, Juliane
A1  - Mayer, Jörg
A1  - Rohnke, Lucie
A1  - Frank, Ulrike
A1  - Stadie, Nicole
A1  - Jentsch, Nadine
A1  - Blech, Anke
A1  - Kurtenbach, Stephanie
A1  - Thieke, Johanna
A1  - Schröder, Astrid
A1  - Stahn, Corinna
A1  - Hörnig, Robin
A1  - Burchert, Frank
A1  - De Bleser, Ria
A1  - Heister, Julian
A1  - Bartels, Luise
A1  - Würzner, Kay-Michael
A1  - Böhme, Romy
A1  - Burmester, Juliane
A1  - Krajewski, Melanie
A1  - Nager, Wido
A1  - Jungehülsing, Gerhard Jan
A1  - Wartenburger, Isabell
A1  - Jöbges, Michael
A1  - Schwilling, Eleonore
A1  - Lidzba, Karen
A1  - Winkler, Susanne
A1  - Konietzko, Andreas
A1  - Krägeloh-Mann, Ingeborg
A1  - Rilling, Eva
A1  - Wilken, Rainer
A1  - Wismann, Kathrin
A1  - Glandorf, Birte
A1  - Hoffmann, Hannah
A1  - Hinnenkamp, Christiane
A1  - Rohlmann, Insa
A1  - Ludewigt, Jacqueline
A1  - Bittner, Christian
A1  - Orlov, Tatjana
A1  - Claus, Katrin
A1  - Ehemann, Christine
A1  - Winnecken, Andreas
A1  - Hummel, Katja
A1  - Breitenstein, Sarah
ED  - Wahl, Michael
ED  - Stahn, Corinna
ED  - Hanne, Sandra
ED  - Fritzsche, Tom
T1  - Spektrum Patholinguistik = Schwerpunktthema: Von der Programmierung zur Artikulation : Sprechapraxie bei Kindern und Erwachsenen
N2  - Das 3. Herbsttreffen Patholinguistik fand am 21. November 2009 an der Universität Potsdam statt. Der vorliegende Tagungsband enthält die drei Hauptvorträge zum Schwerpunktthema „Von der Programmierung zu Artikulation: Sprechapraxie bei Kindern und Erwachsenen“. Darüber hinaus enthält der Band die Beiträge aus dem Spektrum Patholinguistik, sowie die Abstracts der Posterpräsentationen.
N2  - The 3rd Herbsttreffen Patholinguistik was held on November 21st, 2009 at the University of Potsdam. These proceedings contain the three main lectures of the central topic „From programming to articulation: Apraxia of speech of children and adults “. Additionally this volume contains the contributions of Spektrum Patholinguistik, as well as the abstracts of the poster presentations.
T3  - Spektrum Patholinguistik - 3 
KW  - Patholinguistik
KW  - Sprechapraxie
KW  - Sprachtherapie
KW  - patholinguistics
KW  - apraxia of speech
KW  - speech and language therapy
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45470
SN  - 978-3-86956-079-3
SN  - 1869-3822
SN  - 1866-9433
IS  - 3
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Briest, Franziska
A1  - Grass, Irina
A1  - Sedding, Dagmar
A1  - Moebs, Markus
A1  - Christen, Friederike
A1  - Benecke, Joana
A1  - Fuchs, Karolin
A1  - Mende, Stefanie
A1  - Kaemmerer, Daniel
A1  - Sänger, Jörg
A1  - Kunze, Almut
A1  - Geisler, Christina
A1  - Freitag, Helma
A1  - Lewens, Florentine
A1  - Worpenberg, Lina
A1  - Iwaszkiewicz, Sara
A1  - Siegmund, Britta
A1  - Walther, Wolfgang
A1  - Hummel, Michael
A1  - Grabowski, Patricia
T1  - Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors
JF  - Neuroendocrinology : international journal for basic and clinical studies on neuroendocrine relationships
N2  - Background/Aims: The tumor suppressor p53 is rarely mutated in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) but they frequently show a strong expression of negative regulators of p53, rendering these tumors excellent targets for a p53 recovery therapy. Therefore, we analyzed the mechanisms of a p53 recovery therapy on intestinal neuroendocrine tumors in vitro and in vivo. Methods: By Western blot and immunohistochemistry, we found that in GEP-NEN biopsy material overexpression of MDM2 was present in intestinal NEN. Therefore, we analyzed the effect of a small-molecule inhibitor, nutlin-3a, in p53 wild-type and mutant GEP-NEN cell lines by proliferation assay, flow cytometry, immunofluorescence, Western blot, and by multiplex gene expression analysis. Finally, we analyzed the antitumor effect of nutlin-3a in a xenograft mouse model in vivo. During the study, the tumor volume was determined. Results: The midgut wild-type cell line KRJ-I responded to the treatment with cell cycle arrest and apoptosis. By gene expression analysis, we could demonstrate that nutlins reactivated an antiproliferative p53 response. KRJ-I-derived xenograft tumors showed a significantly decreased tumor growth upon treatment with nutlin-3a in vivo. Furthermore, our data suggest that MDM2 also influences the expression of the oncogene FOXM1 in a p53-independent manner. Subsequently, a combined treatment of nutlin-3a and cisplatin (as chemoresistance model) resulted in synergistically enhanced antiproliferative effects. Conclusion: In summary, MDM2 overexpression is a frequent event in p53 wild-type intestinal neuroendocrine neoplasms and therefore recovery of a p53 response might be a novel personalized treatment approach in these tumors. (c) 2017 S. Karger AG, Basel
KW  - Neuroendocrine tumors
KW  - Signaling
KW  - MDM2
KW  - p53
KW  - FOXM1
KW  - Targeted therapy
Y1  - 2017
U6  - https://doi.org/10.1159/000481506
SN  - 0028-3835
SN  - 1423-0194
VL  - 107
IS  - 1
SP  - 1
EP  - 23
PB  - Karger
CY  - Basel
ER  -