TY - JOUR A1 - Hoffmann, Michael T1 - Wortschatz als Kulturgeschichte Y1 - 2000 ER - TY - JOUR A1 - Hoffmann, Michael T1 - Stil und Semantik : Alte Fragen - neue Antworten? Y1 - 1999 ER - TY - JOUR A1 - Hoffmann, Michael T1 - Thesen zur Varietätenlinguistik Y1 - 1999 UR - http://www.degruyter.com/view/j/zfgl.1999.27.issue-3/zfgl.1999.27.3.309/zfgl.1999.27.3.309.xml ER - TY - JOUR A1 - Hoffmann, Michael T1 - Typische, weniger typische und untypische Texte (Bericht) Y1 - 1999 ER - TY - JOUR A1 - Hoffmann, Michael T1 - Aus der Arbeit der Dudenredaktion (Bericht) Y1 - 1999 ER - TY - GEN A1 - Hoffmann, Mathias A1 - Schulz-Hanke, Maximilian A1 - Alba, Juana Garcia A1 - Jurisch, Nicole A1 - Hagemann, Ulrike A1 - Sachs, Torsten A1 - Sommer, Michael A1 - Augustin, Jürgen T1 - A simple calculation algorithm to separate high-resolution CH4 flux measurements into ebullition- and diffusion-derived components T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Processes driving the production, transformation and transport of methane (CH4) in wetland ecosystems are highly complex. We present a simple calculation algorithm to separate open-water CH4 fluxes measured with automatic chambers into diffusion- and ebullition-derived components. This helps to reveal underlying dynamics, to identify potential environmental drivers and, thus, to calculate reliable CH4 emission estimates. The flux separation is based on identification of ebullition-related sudden concentration changes during single measurements. Therefore, a variable ebullition filter is applied, using the lower and upper quartile and the interquartile range (IQR). Automation of data processing is achieved by using an established R script, adjusted for the purpose of CH4 flux calculation. The algorithm was validated by performing a laboratory experiment and tested using flux measurement data (July to September 2013) from a former fen grassland site, which converted into a shallow lake as a result of rewetting. Ebullition and diffusion contributed equally (46 and 55 %) to total CH4 emissions, which is comparable to ratios given in the literature. Moreover, the separation algorithm revealed a concealed shift in the diurnal trend of diffusive fluxes throughout the measurement period. The water temperature gradient was identified as one of the major drivers of diffusive CH4 emissions, whereas no significant driver was found in the case of erratic CH4 ebullition events. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 604 KW - water methane emissions KW - chamber system KW - CO2 KW - lake KW - fen KW - exchange KW - mechanism KW - turbulence KW - transport KW - reservior Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416659 SN - 1866-8372 IS - 604 SP - 109 EP - 118 ER - TY - GEN A1 - Hoffmann, Mathias A1 - Jurisch, Nicole A1 - Alba, Juana Garcia A1 - Borraz, Elisa Albiac A1 - Schmidt, Marten A1 - Huth, Vytas A1 - Rogasik, Helmut A1 - Rieckh, Helene A1 - Verch, Gernot A1 - Sommer, Michael A1 - Augustin, Jürgen T1 - Detecting small-scale spatial heterogeneity and temporal dynamics of soil organic carbon (SOC) stocks BT - a comparison between automatic chamber-derived C budgets and repeated soil inventories T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Carbon (C) sequestration in soils plays a key role in the global C cycle. It is therefore crucial to adequately monitor dynamics in soil organic carbon (Delta SOC) stocks when aiming to reveal underlying processes and potential drivers. However, small-scale spatial (10-30 m) and temporal changes in SOC stocks, particularly pronounced in arable lands, are hard to assess. The main reasons for this are limitations of the well-established methods. On the one hand, repeated soil inventories, often used in long-term field trials, reveal spatial patterns and trends in Delta SOC but require a longer observation period and a sufficient number of repetitions. On the other hand, eddy covariance measurements of C fluxes towards a complete C budget of the soil-plant-atmosphere system may help to obtain temporal Delta SOC patterns but lack small-scale spatial resolution. To overcome these limitations, this study presents a reliable method to detect both short-term temporal dynamics as well as small-scale spatial differences of Delta SOC using measurements of the net ecosystem carbon balance (NECB) as a proxy. To estimate the NECB, a combination of automatic chamber (AC) measurements of CO2 exchange and empirically modeled aboveground biomass development (NPPshoot / were used. To verify our method, results were compared with Delta SOC observed by soil resampling. Soil resampling and AC measurements were performed from 2010 to 2014 at a colluvial depression located in the hummocky ground moraine landscape of northeastern Germany. The measurement site is characterized by a variable groundwater level (GWL) and pronounced small-scale spatial heterogeneity regarding SOC and nitrogen (Nt) stocks. Tendencies and magnitude of Delta SOC values derived by AC measurements and repeated soil inventories corresponded well. The period of maximum plant growth was identified as being most important for the development of spatial differences in annual Delta SOC. Hence, we were able to confirm that AC-based C budgets are able to reveal small-scale spatial differences and short-term temporal dynamics of Delta SOC. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 666 KW - net ecosystem exchange KW - North Central region KW - no-till ecosystem KW - eddy covariance KW - CO2 fluxes KW - dioxide exchange KW - United States KW - gas-exchange KW - agricultural landscapes KW - monitoring networks Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-417118 SN - 1866-8372 IS - 666 ER - TY - CHAP A1 - Hoffmann, Dierk A1 - Schwartz, Michael A1 - Wentker, Hermann ED - Hüttmann, Jens ED - von Arnim-Rosenthal, Anna T1 - Die DDR als Chance T2 - Diktatur und Demokratie im Unterricht : der Fall DDR Y1 - 2017 SN - 978-3-86331-337-1 SP - 39 EP - 53 PB - Metropol CY - Berlin ER - TY - JOUR A1 - Funk, Roger A1 - Li, Yong A1 - Hoffmann, Carsten A1 - Reiche, Matthias A1 - Zhang, Zhuodong A1 - Li, Junjie A1 - Sommer, Michael T1 - Using Cs-137 to estimate wind erosion and dust deposition on grassland in Inner Mongolia-selection of a reference site and description of the temporal variability JF - Plant and soil N2 - The aims of this study were to identify areas of wind erosion and dust deposition and to quantify the effects of different grazing intensities on soil redistribution rates in grasslands based on the Cs-137 technique. Because the method uses a reference inventory as threshold for erosion or deposition, the classification of any other site as source or sink for dust depends on the accurate selection of this reference site. Measurements of Cs-137 inventories and depth distributions were carried out at pasture sites with predominant species of Stipa grandis and Leymus chinensis which are grazed with different intensities. Additional measurements were made at arable land, plant-covered sand dunes and alluvial plains. Wind-induced soil erosion and dust deposition rates were calculated from Cs-137 inventories by means of the "Profile-Distribution" and the "Mass Balance II" models. The selection of the reference site was based on fluid dynamical and process-determining parameters. The chosen site should meet the following four conditions: (i) located at a summit position with obviously low deposition rates, (ii) sufficient vegetation cover to prevent wind erosion, (iii) plane to exclude water erosion and (iv) in the wind/dust shadow of a higher elevation. The measured reference inventory of Cs-137 was 1967(+/- 102) Bqm(-2) located at a summit position of moderately grazed Leymus chinensis steppe. The Cs-137 inventories at other sites ranged from 1330 Bqm(-2) at heavily grazed sites to 5119 Bqm(-2) at river deposits, representing annual average soil losses of up to 130 tkm(-2) and deposits of up to 540 tkm(-2), respectively. The calculated annual averages of dust depositions at ungrazed Leymus chinensis sites were related to the dust storm frequencies of the last 50 years resulting in a description of the temporal variability of annual dust depositions from about 154 tkm(-2) in the 1960s to 26 tkm(-2) at recent times. Based on this quantification already 80% of the total dust depositions can be related to the 20 years between the 1960s and the end of the 1970s and only 20% to the time between 1980 and 2001. Cs-137 technique is a promising method to assess the effect of grazing intensity and land use types on the spatial variability of wind-induced soil and dust redistribution processes in semi-arid grasslands. However, considerable efforts are needed to identify a reliable reference site, because erosion and deposition induced by wind may occur at the same places. The combination of the dust deposition rates derived from Cs-137 profile data with the dust storm frequencies is helpful for a better reconstruction of the temporal variability of dust deposition and wind erosion in this region. The calculated recent deposition rates of about 20 tkm(-2) are in good agreement with data of other authors. KW - Cs-137 KW - Grassland KW - Wind erosion KW - Dust deposition KW - Reference site Y1 - 2012 U6 - https://doi.org/10.1007/s11104-011-0964-y SN - 0032-079X VL - 351 IS - 1-2 SP - 293 EP - 307 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Reiche, Matthias A1 - Funk, Roger A1 - Zhang, Zhuodong A1 - Hoffmann, Carsten A1 - Reiche, Johannes A1 - Wehrhan, Marc A1 - Li, Yong A1 - Sommer, Michael T1 - Application of satellite remote sensing for mapping wind erosion risk and dust emission-deposition in Inner Mongolia grassland, China JF - Grassland science N2 - Intensive grazing leads to land degradation and desertification of grassland ecosystems followed by serious environmental and social problems. The Xilingol steppe grassland in Inner Mongolia, China, which has been a sink area for dust for centuries, is strongly affected by the negative effects of overgrazing and wind erosion. The aim of this study is the provision of a wind erosion risk map with a spatial high resolution of 25 m to identify actual source and sink areas. In an integrative approach, field measurements of vegetation features and surface roughness length z0 were combined with Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) image data for a land use classification. To determine the characteristics of the different land use classes, a field observation (ground truth) was performed in April 2009. The correlation of vegetation height and z0 (R2 = 0.8, n = 55) provided the basis for a separation of three main classes, grassland, non-vegetation and other. The integration of the soil-adjusted vegetation index (SAVI) and the spectral information from the atmospheric corrected ASTER bands 1, 2 and 3 (visible to near-infrared) led to a classification of the overall accuracy (OA) of 0.79 with a kappa () statistic of 0.74, respectively. Additionally, a digital elevation model (DEM) was used to identify topographical effects in relation to the main wind direction, which enabled a qualitative estimation of potential dust deposition areas. The generated maps result in a significantly higher description of the spatial variability in the Xilingol steppe grassland reflecting the different land use intensities on the current state of the grassland less, moderately and highly degraded. The wind erosion risk map enables the identification of characteristic mineral dust sources, sinks and transition zones. KW - Advanced Spaceborne Thermal Emission and Reflection Radiometer data KW - dust emission and deposition KW - soil-adjusted vegetation index KW - semiarid grassland KW - wind erosion Y1 - 2012 U6 - https://doi.org/10.1111/j.1744-697X.2011.00235.x SN - 1744-6961 VL - 58 IS - 1 SP - 8 EP - 19 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Zhang, Zhuodong A1 - Wieland, Ralf A1 - Reiche, Matthias A1 - Funk, Roger A1 - Hoffmann, Carsten A1 - Li, Yong A1 - Sommer, Michael T1 - Identifying sensitive areas to wind erosion in the xilingele grassland by computational fluid dynamics modelling JF - Ecological informatics : an international journal on ecoinformatics and computational ecolog N2 - In order to identify the areas in the Xilingele grassland which are sensitive to wind erosion, a computational fluid dynamics model (CFD-WEM) was used to simulate the wind fields over a region of 37 km(2) which contains different topography and land use types. Previous studies revealed the important influences of topography and land use on wind erosion in the Xilingele grassland. Topography influences wind fields at large scale, and land use influences wind fields near the ground. Two steps were designed to implement the CFD wind simulation, and they were respectively to simulate the influence of topography and surface roughness on the wind. Digital elevation model (DEM) and surface roughness length were the key inputs for the CFD simulation. The wind simulation by CFD-WEM was validated by a wind data set which was measured simultaneously at six positions in the field. Three scenarios with different wind velocities were designed based on observed dust storm events, and wind fields were simulated according to these scenarios to predict the sensitive areas to wind erosion. General assumptions that cropland is the most sensitive area to wind erosion and heavily and moderately grazed grasslands are both sensitive etc. can be refined by the modelling of CFD-WEM. Aided by the results of this study, the land use planning and protection measures against wind erosion can be more efficient. Based on the case study in the Xilingele grassland, a method of regional wind erosion assessment aided by CFD wind simulation is summarized. The essence of this method is a combination of CFD wind simulation and determination of threshold wind velocity for wind erosion. Because of the physically-based simulation and the flexibility of the method, it can be generalised to other regions. KW - Sensitive areas KW - Wind erosion KW - Computational fluid dynamics KW - Grassland KW - Surface roughness Y1 - 2012 U6 - https://doi.org/10.1016/j.ecoinf.2011.12.002 SN - 1574-9541 VL - 8 IS - 5 SP - 37 EP - 47 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zhang, Zhuo-dong A1 - Wieland, Ralf A1 - Reiche, Matthias A1 - Funk, Roger A1 - Hoffmann, Carsten A1 - Li, Yong A1 - Sommer, Michael T1 - A computational fluid dynamics model for wind simulation: model implementation and experimental validation JF - Journal of Zhejiang University : an international journal ; Science A, Applied physics & engineering : an international applied physics & engineering journal N2 - To provide physically based wind modelling for wind erosion research at regional scale, a 3D computational fluid dynamics (CFD) wind model was developed. The model was programmed in C language based on the Navier-Stokes equations, and it is freely available as open source. Integrated with the spatial analysis and modelling tool (SAMT), the wind model has convenient input preparation and powerful output visualization. To validate the wind model, a series of experiments was conducted in a wind tunnel. A blocking inflow experiment was designed to test the performance of the model on simulation of basic fluid processes. A round obstacle experiment was designed to check if the model could simulate the influences of the obstacle on wind field. Results show that measured and simulated wind fields have high correlations, and the wind model can simulate both the basic processes of the wind and the influences of the obstacle on the wind field. These results show the high reliability of the wind model. A digital elevation model (DEM) of an area (3800 m long and 1700 m wide) in the Xilingele grassland in Inner Mongolia (autonomous region, China) was applied to the model, and a 3D wind field has been successfully generated. The clear implementation of the model and the adequate validation by wind tunnel experiments laid a solid foundation for the prediction and assessment of wind erosion at regional scale. KW - Wind model KW - Computational fluid dynamics (CFD) KW - Wind erosion KW - Wind tunnel experiments KW - Spatial analysis and modelling tool (SAMT) KW - Open source Y1 - 2012 U6 - https://doi.org/10.1631/jzus.A1100231 SN - 1673-565X VL - 13 IS - 4 SP - 274 EP - 283 PB - Zhejiang University Press CY - Hangzou ER - TY - JOUR A1 - Zhang, Zhuodong A1 - Wieland, Ralf A1 - Reiche, Matthias A1 - Funk, Roger A1 - Hoffmann, Carsten A1 - Li, Yong A1 - Sommer, Michael T1 - Wind modelling for wind erosion research by open source computational fluid dynamics JF - Ecological informatics : an international journal on ecoinformatics and computational ecolog N2 - The open source computational fluid dynamics (CFD) wind model (CFD-WEM) for wind erosion research in the Xilingele grassland in Inner Mongolia (autonomous region, China) is compared with two open source CFD models Gerris and OpenFOAM. The evaluation of these models was made according to software technology, implemented methods, handling, accuracy and calculation speed. All models were applied to the same wind tunnel data set. Results show that the simplest CFD-WEM has the highest calculation speed with acceptable accuracy, and the most powerful OpenFOAM produces the simulation with highest accuracy and the lowest calculation speed. Gerris is between CFD-WEM and OpenFOAM. It calculates faster than OpenFOAM, and it is capable to solve different CFD problems. CFD-WEM is the optimal model to be further developed for wind erosion research in Inner Mongolia grassland considering its efficiency and the uncertainties of other input data. However, for other applications using CFD technology, Gerris and OpenFOAM can be good choices. This paper shows the powerful capability of open source CFD software in wind erosion study, and advocates more involvement of open source technology in wind erosion and related ecological researches. KW - Computational fluid dynamics KW - Wind modelling KW - Open source KW - Wind erosion KW - Gerris KW - OpenFOAM KW - SAMT Y1 - 2011 U6 - https://doi.org/10.1016/j.ecoinf.2011.02.001 SN - 1574-9541 VL - 6 IS - 5 SP - 316 EP - 324 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schaller, Jörg A1 - Scherwietes, Eric A1 - Gerber, Lukas A1 - Vaidya, Shrijana A1 - Kaczorek, Danuta A1 - Pausch, Johanna A1 - Barkusky, Dietmar A1 - Sommer, Michael A1 - Hoffmann, Mathias T1 - Silica fertilization improved wheat performance and increased phosphorus concentrations during drought at the field scale JF - Scientific reports N2 - Drought and the availability of mineable phosphorus minerals used for fertilization are two of the important issues agriculture is facing in the future. High phosphorus availability in soils is necessary to maintain high agricultural yields. Drought is one of the major threats for terrestrial ecosystem performance and crop production in future. Among the measures proposed to cope with the upcoming challenges of intensifying drought stress and to decrease the need for phosphorus fertilizer application is the fertilization with silica (Si). Here we tested the importance of soil Si fertilization on wheat phosphorus concentration as well as wheat performance during drought at the field scale. Our data clearly showed a higher soil moisture for the Si fertilized plots. This higher soil moisture contributes to a better plant performance in terms of higher photosynthetic activity and later senescence as well as faster stomata responses ensuring higher productivity during drought periods. The plant phosphorus concentration was also higher in Si fertilized compared to control plots. Overall, Si fertilization or management of the soil Si pools seem to be a promising tool to maintain crop production under predicted longer and more serve droughts in the future and reduces phosphorus fertilizer requirements. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-00464-7 SN - 2045-2322 VL - 11 IS - 1 PB - Macmillan Publishers Limited, part of Springer Nature CY - [London] ER - TY - JOUR A1 - Landwehr-Kenzel, Sybille A1 - Zobel, Anne A1 - Hoffmann, Henrike A1 - Landwehr, Niels A1 - Schmueck-Henneresse, Michael A1 - Schachtner, Thomas A1 - Roemhild, Andy A1 - Reinke, Petra T1 - Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy JF - Kidney international : official journal of the International Society of Nephrology N2 - Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients. Heparinized blood from 200 individuals including healthy controls, dialysis patients with end stage renal disease and patients 1, 5, 10, 15, 20 years after kidney transplantation were analyzed. Differentiation and maturation of nTregs were studied by flow cytometry in order to compare dialysis patients and kidney transplanted patients under maintenance immunosuppression to healthy controls. CD127 expressing CD4(+)CD25(high)FoxP3(+) nTregs were detectable at increased frequencies in dialysis patients with no negative impact on the nTreg end product quality and therapeutic usefulness of the ex vivo expanded nTregs. Further, despite that immunosuppression mildly altered nTreg maturation, neither dialysis nor pharmacological immunosuppression or previous acute rejection episodes impeded nTreg survival in vivo. Accordingly, the generation of autologous, highly pure nTreg products is feasible and qualifies patients awaiting or having received allogenic kidney transplantation for adoptive nTreg therapy. Thus, our novel treatment approach may enable us to reduce the incidence of organ rejection and reduce the need of long-term immunosuppression. KW - adoptive T-cell transfer KW - autologous cell therapy KW - end-stage renal disease KW - kidney transplantation KW - regulatory T cells Y1 - 2018 U6 - https://doi.org/10.1016/j.kint.2018.01.021 SN - 0085-2538 SN - 1523-1755 VL - 93 IS - 6 SP - 1452 EP - 1464 PB - Elsevier CY - New York ER - TY - BOOK A1 - Siehr, Karl-Heinz A1 - Kern, Friederike A1 - Hoffmann, Michael A1 - Großbröhmer, Christoph A1 - Mühlbauer, Evelyn A1 - Berner, Elisabeth A1 - Leubner, Martin A1 - Friese, Antonia A1 - Preis, Matthias A1 - Josting, Petra A1 - Höfner, Marion A1 - Schepe, Kerstin ED - Kern, Friederike ED - Siehr, Karl-Heinz T1 - Sport als Thema im Deutschunterricht BT - Fachliche Grundlagen – Unterrichtsanregungen – Unterrichtsmaterialien N2 - Ein Deutschunterricht, der die Alltags- und Medienkultur der Schüler und Schülerinnen ernst nimmt, darf Sporttexte nicht unberücksichtigt lassen. Zu sehr ist der Sport in all seinen Facetten Teil der Lebenswelt vieler Schülerinnen und Schüler geworden. Die Frage ist nicht mehr, ob der Deutschunterricht darauf zu reagieren hat, die Frage ist vielmehr, wie er dies tun und welche Sporttexte er dabei nutzen kann. Auch wenn die Suche nach sinnvollen Bezügen zwischen Sport und Deutschunterricht schon seit längerem intensiv betrieben wird, offenbart das vielschichtige Kulturphänomen „Sport“ immer wieder neue interessante Seiten, die es lohnen, fachdidaktisch behandelt zu werden. Die zehn Beiträge in diesem Band verstehen sich als Unterrichtsanregungen für den kompetenzorientierten Deutschunterricht. Sie bedienen Betrachtungen zum Sport aus literarischer, sprachlicher und medialer Perspektive. Die theoretisch-begrifflichen Aspekte der jeweiligen Themen werden soweit behandelt, wie sie für das Verständnis erforderlich sind. Im Zentrum vieler Beiträge stehen Unterrichtsszenarien mit kommentierten Texten und Aufgaben, die für die Unterrichtsvorbereitung oder für den Unterricht selbst genutzt werden können. KW - Deutschunterricht KW - Sportsprache KW - Varietäten KW - Sportberichterstattung KW - Medienanalyse KW - Deutschdidaktik Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95307 SN - 978-3-86956-381-7 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Heit, Benjamin A1 - Yuan, Xiaohui A1 - Weber, Michael H. A1 - Geissler, Wolfram H. A1 - Jokat, Wilfried A1 - Lushetile, Bufelo A1 - Hoffmann, Karl-Heinz T1 - Crustal thickness and V-p/V-s ratio in NW Namibia from receiver functions: Evidence for magmatic underplating due to mantle plume-crust interaction JF - Geophysical research letters N2 - A seismological network was operated at the junction of the aseismic Walvis Ridge with the northwestern Namibian coast. We mapped crustal thickness and bulk V-p/V-s ratio by the H-k analysis of receiver functions. In the Damara Belt, the crustal thickness is similar to 35km with a V-p/V-s ratio of <1.75. The crust is similar to 30km thick at the coast in the Kaoko Belt. Strong variations in crustal thickness and V-p/V-s ratios are found at the landfall of the Walvis Ridge. Here and at similar to 150km northeast of the coast, the crustal thickness increases dramatically reaching 44km and the V-p/V-s ratios are extremely high (similar to 1.89). These anomalies are interpreted as magmatic underplating produced by the mantle plume during the breakup of Gondwana. The area affected by the plume is smaller than 300km in diameter, possibly ruling out the existence of a large plume head under the continent during the breakup. KW - crustal thickness KW - V-p KW - V-s ratios KW - magmatic underplating KW - Walvis Ridge KW - continental breakup Y1 - 2015 U6 - https://doi.org/10.1002/2015GL063704 SN - 0094-8276 SN - 1944-8007 VL - 42 IS - 9 SP - 3330 EP - 3337 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Peter, Lena A1 - Wendering, Désirée Jacqueline A1 - Schlickeiser, Stephan A1 - Hoffmann, Henrike A1 - Noster, Rebecca A1 - Wagner, Dimitrios Laurin A1 - Zarrinrad, Ghazaleh A1 - Münch, Sandra A1 - Picht, Samira A1 - Schulenberg, Sarah A1 - Moradian, Hanieh A1 - Mashreghi, Mir-Farzin A1 - Klein, Oliver A1 - Gossen, Manfred A1 - Roch, Toralf A1 - Babel, Nina A1 - Reinke, Petra A1 - Volk, Hans-Dieter A1 - Amini, Leila A1 - Schmueck-Henneresse, Michael T1 - Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients JF - Molecular therapy methods and clinical development N2 - Solid organ transplant (SOT) recipients receive therapeutic immunosuppression that compromises their immune response to infections and vaccines. For this reason, SOT patients have a high risk of developing severe coronavirus disease 2019 (COVID-19) and an increased risk of death from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Moreover, the efficiency of immunotherapies and vaccines is reduced due to the constant immunosuppression in this patient group. Here, we propose adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, tacrolimus, for optimized performance in the immunosuppressed patient. Using a ribonucleoprotein approach of CRISPR-Cas9 technology, we have generated tacrolimus-resistant SARS-CoV-2-specific T cell products from convalescent donors and demonstrate their specificity and function through characterizations at the single-cell level, including flow cytometry, single-cell RNA (scRNA) Cellular Indexing of Transcriptomes and Epitopes (CITE), and T cell receptor (TCR) sequencing analyses. Based on the promising results, we aim for clinical validation of this approach in transplant recipients. Additionally, we propose a combinatory approach with tacrolimus, to prevent an overshooting immune response manifested as bystander T cell activation in the setting of severe COVID-19 immunopathology, and tacrolimus-resistant SARS-CoV-2-specific T cell products, allowing for efficient clearance of viral infection. Our strategy has the potential to prevent severe COVID-19 courses in SOT or autoimmunity settings and to prevent immunopathology while providing viral clearance in severe non-transplant COVID-19 cases. Y1 - 2022 U6 - https://doi.org/10.1016/j.omtm.2022.02.012 SN - 2329-0501 VL - 25 SP - 52 EP - 73 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Hoffmann, Stephanie A1 - Tschorn, Mira A1 - Michalski, Niels A1 - Hoebel, Jens A1 - Förstner, Bernd Rainer A1 - Rapp, Michael A. A1 - Spallek, Jacob T1 - Association of regional socioeconomic deprivation and rurality with global developmental delay in early childhood BT - Data from mandatory school entry examinations in Germany JF - Health & place : an international journal ; a social science & medicine publication ; incorporating Geographia medica N2 - Background: From birth to young adulthood, health and development of young people are strongly linked to their living situation, including their family's socioeconomic position (SEP) and living environment. The impact of regional characteristics on development in early childhood beyond family SEP has been rarely investigated. This study aimed to identify regional predictors of global developmental delay at school entry taking family SEP into consideration. Method: We used representative, population-based data from mandatory school entry examinations of the German federal state of Brandenburg in 2018/2019 with n=22,801 preschool children. By applying binary multilevel models, we hierarchically analyzed the effect of regional deprivation defined by the German Index of Socioeconomic Deprivation (GISD) and rurality operationalized as inverted population density of the children's school district on global developmental delay (GDD) while adjusting for family SEP (low, medium and high) Results: Family SEP was significantly and strongly linked to GDD. Children with the highest family SEP showed a lower odds for GDD compared to a medium SEP (female: OR=4.26, male: OR=3.46) and low SEP (female: OR=16.58, male: OR=12.79). Furthermore, we discovered a smaller, but additional and independent effect of regional socioeconomic deprivation on GDD, with a higher odds for children from a more deprived school district (female: OR=1.35, male: OR=1.20). However, rurality did not show a significant link to GDD in preschool children beyond family SEP and regional deprivation. Conclusion: Family SEP and regional deprivation are risk factors for child development and of particular interest to promote health of children in early childhood and over the life course. KW - Health inequalities KW - Spatial analysis KW - Regional deprivation KW - Rurality KW - Developmental delay KW - Children Y1 - 2022 U6 - https://doi.org/10.1016/j.healthplace.2022.102794 SN - 1353-8292 SN - 1873-2054 VL - 75 PB - Elsevier Science CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Jaehn, Philipp A1 - Sasko, Benjamin A1 - Holmberg, Christine A1 - Hoffmann, Stephanie A1 - Spallek, Jacob A1 - Kelesidis, Theodoros A1 - Rapp, Michael A. A1 - Westhoff, Timm H. A1 - Ritter, Oliver A1 - Pagonas, Nikolaos T1 - Levels of high-density lipoprotein lipid peroxidation according to spatial socioeconomic deprivation and rurality among patients with coronary artery disease JF - European journal of preventive cardiology Y1 - 2022 U6 - https://doi.org/10.1093/eurjpc/zwac068 SN - 2047-4873 SN - 2047-4881 VL - 29 IS - 15 SP - E343 EP - E346 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Nitzsche, Kai Nils A1 - Kleeberg, Andreas A1 - Hoffmann, Carsten A1 - Merz, Christoph A1 - Premke, Katrin A1 - Gessler, Arthur A1 - Sommer, Michael A1 - Kayler, Zachary E. T1 - Kettle holes reflect the biogeochemical characteristics of their catchment area and the intensity of the element-specific input JF - Journal of soils and sediments : protection, risk assessment and remediation N2 - Purpose Kettle holes are small inland water bodies known to be dominated by terrigenous material; however, the processes and structures that drive the enrichment and depletion of specific geochemical elements in the water column and kettle hole sediment remain unclear. We hypothesized that the mobile elements (Ca, Fe, K, P) behave different from each other in their transport, intermediate soil retention, and final accumulation in the kettle hole sediment. Methods Topsoils from transects spanning topographic positions from erosional to depositional areas, sediment cores, shallow groundwater, and kettle hole water of two glacial kettle holes in NE Germany (Rittgarten (RG) and Kraatz (KR)) were collected. The Fe, Ca, K, and total P (TP) concentrations were quantified and additionally the major anions in shallow groundwater and kettle hole water. The element-specific mobilization, relocation, and, finally, accumulation in the sediment were investigated by enrichment factors. Furthermore, a piper diagram was used to estimate groundwater flow directions and pond-internal processes. Results At KR only, the upper 10 cm of the kettle hole sediment reflected the relative element composition of the eroded terrestrial soils. The sediment from both kettle holes was enriched in Ca, Fe, K, and P compared to topsoils, indicating several possible processes including the input of clay and silt sized particles enriched in these elements, fertilizer input, and pond-internal processes including biogenic calcite and hydroxyapatite precipitation, Fe-P binding (KR), FeSx formation (RG), and elemental fixation and deposition via floating macrophytes (RG). High Ca concentrations in the kettle hole water indicated a high input of Ca from shallow groundwater inflow, while Ca precipitation in the kettle hole water led to lower Ca concentration in groundwater outflow. Conclusions The considerable element losses in the surrounding soils and the inputs into the kettle holes should be addressed by comprehensive soil and water protection measures, i.e., avoiding tillage, fertilizing conservatively, and creating buffer zones. KW - Agricultural soils KW - Soil erosion KW - Element mobility KW - Phosphorus KW - Kettle hole KW - Sediment Y1 - 2022 U6 - https://doi.org/10.1007/s11368-022-03145-8 SN - 1439-0108 SN - 1614-7480 VL - 22 IS - 3 SP - 994 EP - 1009 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Nendel, Claas A1 - Reckling, Moritz A1 - Debaeke, Philippe A1 - Schulz, Susanne A1 - Berg-Mohnicke, Michael A1 - Constantin, Julie A1 - Fronzek, Stefan A1 - Hoffmann, Munir A1 - Jakšić, Snežana A1 - Kersebaum, Kurt-Christian A1 - Klimek-Kopyra, Agnieszka A1 - Raynal, Hélène A1 - Schoving, Céline A1 - Stella, Tommaso A1 - Battisti, Rafael T1 - Future area expansion outweighs increasing drought risk for soybean in Europe JF - Global change biology N2 - The European Union is highly dependent on soybean imports from overseas to meet its protein demands. Individual Member States have been quick to declare self-sufficiency targets for plant-based proteins, but detailed strategies are still lacking. Rising global temperatures have painted an image of a bright future for soybean production in Europe, but emerging climatic risks such as drought have so far not been included in any of those outlooks. Here, we present simulations of future soybean production and the most prominent risk factors across Europe using an ensemble of climate and soybean growth models. Projections suggest a substantial increase in potential soybean production area and productivity in Central Europe, while southern European production would become increasingly dependent on supplementary irrigation. Average productivity would rise by 8.3% (RCP 4.5) to 8.7% (RCP 8.5) as a result of improved growing conditions (plant physiology benefiting from rising temperature and CO2 levels) and farmers adapting to them by using cultivars with longer phenological cycles. Suitable production area would rise by 31.4% (RCP 4.5) to 37.7% (RCP 8.5) by the mid-century, contributing considerably more than productivity increase to the production potential for closing the protein gap in Europe. While wet conditions at harvest and incidental cold spells are the current key challenges for extending soybean production, the models and climate data analysis anticipate that drought and heat will become the dominant limitations in the future. Breeding for heat-tolerant and water-efficient genotypes is needed to further improve soybean adaptation to changing climatic conditions. KW - genotypes KW - legumes KW - maturity groups KW - protein crops KW - protein transition KW - resilience Y1 - 2022 U6 - https://doi.org/10.1111/gcb.16562 SN - 1354-1013 SN - 1365-2486 VL - 29 IS - 5 SP - 1340 EP - 1358 PB - Wiley-Blackwell CY - Ocford [u.a] ER - TY - JOUR A1 - Abramowski, Attila A1 - Acero, F. A1 - Aharonian, Felix A. A1 - Akhperjanian, A. G. A1 - Anton, Gisela A1 - Balzer, Arnim A1 - Barnacka, Anna A1 - de Almeida, U. Barres A1 - Becherini, Yvonne A1 - Becker, J. A1 - Behera, B. A1 - Bernlöhr, K. A1 - Birsin, E. A1 - Biteau, Jonathan A1 - Bochow, A. A1 - Boisson, Catherine A1 - Bolmont, J. A1 - Bordas, Pol A1 - Brucker, J. A1 - Brun, Francois A1 - Brun, Pierre A1 - Bulik, Tomasz A1 - Buesching, I. A1 - Carrigan, Svenja A1 - Casanova, Sabrina A1 - Cerruti, M. A1 - Chadwick, Paula M. A1 - Charbonnier, A. A1 - Chaves, Ryan C. G. A1 - Cheesebrough, A. A1 - Clapson, A. C. A1 - Coignet, G. A1 - Cologna, Gabriele A1 - Conrad, Jan A1 - Dalton, M. A1 - Daniel, M. K. A1 - Davids, I. D. A1 - Degrange, B. A1 - Deil, C. A1 - Dickinson, H. J. A1 - Djannati-Ataï, A. A1 - Domainko, W. A1 - Drury, L. O'C. A1 - Dubus, G. A1 - Dutson, K. A1 - Dyks, J. A1 - Dyrda, M. A1 - Egberts, Kathrin A1 - Eger, P. A1 - Espigat, P. A1 - Fallon, L. A1 - Farnier, C. A1 - Fegan, S. A1 - Feinstein, F. A1 - Fernandes, M. V. A1 - Fiasson, A. A1 - Fontaine, G. A1 - Foerster, A. A1 - Fuessling, M. A1 - Gallant, Y. A. A1 - Gast, H. A1 - Gerard, L. A1 - Gerbig, D. A1 - Giebels, B. A1 - Glicenstein, J. F. A1 - Glueck, B. A1 - Goret, P. A1 - Goering, D. A1 - Haeffner, S. A1 - Hague, J. D. A1 - Hampf, D. A1 - Hauser, M. A1 - Heinz, S. A1 - Heinzelmann, G. A1 - Henri, G. A1 - Hermann, G. A1 - Hinton, James Anthony A1 - Hoffmann, A. A1 - Hofmann, W. A1 - Hofverberg, P. A1 - Holler, M. A1 - Horns, D. A1 - Jacholkowska, A. A1 - de Jager, O. C. A1 - Jahn, C. A1 - Jamrozy, M. A1 - Jung, I. A1 - Kastendieck, M. A. A1 - Katarzynski, K. A1 - Katz, U. A1 - Kaufmann, S. A1 - Keogh, D. A1 - Khangulyan, D. A1 - Khelifi, B. A1 - Klochkov, D. A1 - Kluzniak, W. A1 - Kneiske, T. A1 - Komin, Nu. A1 - Kosack, K. A1 - Kossakowski, R. A1 - Laffon, H. A1 - Lamanna, G. A1 - Lennarz, D. A1 - Lohse, T. A1 - Lopatin, A. A1 - Lu, C. -C. A1 - Marandon, V. A1 - Marcowith, Alexandre A1 - Masbou, J. A1 - Maurin, D. A1 - Maxted, N. A1 - Mayer, M. A1 - McComb, T. J. L. A1 - Medina, M. C. A1 - Mehault, J. A1 - Moderski, R. A1 - Moulin, Emmanuel A1 - Naumann, C. L. A1 - Naumann-Godo, M. A1 - de Naurois, M. A1 - Nedbal, D. A1 - Nekrassov, D. A1 - Nguyen, N. A1 - Nicholas, B. A1 - Niemiec, J. A1 - Nolan, S. J. A1 - Ohm, S. A1 - Wilhelmi, E. de Ona A1 - Opitz, B. A1 - Ostrowski, M. A1 - Oya, I. A1 - Panter, M. A1 - Arribas, M. Paz A1 - Pedaletti, G. A1 - Pelletier, G. A1 - Petrucci, P. -O. A1 - Pita, S. A1 - Puehlhofer, G. A1 - Punch, M. A1 - Quirrenbach, A. A1 - Raue, M. A1 - Rayner, S. M. A1 - Reimer, A. A1 - Reimer, O. A1 - Renaud, M. A1 - de los Reyes, R. A1 - Rieger, F. A1 - Ripken, J. A1 - Rob, L. A1 - Rosier-Lees, S. A1 - Rowell, G. A1 - Rudak, B. A1 - Rulten, C. B. A1 - Ruppel, J. A1 - Sahakian, V. A1 - Sanchez, David M. A1 - Santangelo, Andrea A1 - Schlickeiser, R. A1 - Schoeck, F. M. A1 - Schulz, A. A1 - Schwanke, U. A1 - Schwarzburg, S. A1 - Schwemmer, S. A1 - Sheidaei, F. A1 - Skilton, J. L. A1 - Sol, H. A1 - Spengler, G. A1 - Stawarz, L. A1 - Steenkamp, R. A1 - Stegmann, Christian A1 - Stinzing, F. A1 - Stycz, K. A1 - Sushch, Iurii A1 - Szostek, A. A1 - Tavernet, J. -P. A1 - Terrier, R. A1 - Tluczykont, M. A1 - Valerius, K. A1 - van Eldik, C. A1 - Vasileiadis, G. A1 - Venter, C. A1 - Vialle, J. P. A1 - Viana, A. A1 - Vincent, P. A1 - Voelk, H. J. A1 - Volpe, F. A1 - Vorobiov, S. A1 - Vorster, M. A1 - Wagner, S. J. A1 - Ward, M. A1 - White, R. A1 - Wierzcholska, A. A1 - Zacharias, M. A1 - Zajczyk, A. A1 - Zdziarski, A. A. A1 - Zech, Alraune A1 - Zechlin, H. -S. A1 - Aleksic, J. A1 - Antonelli, L. A. A1 - Antoranz, P. A1 - Backes, Michael A1 - Barrio, J. A. A1 - Bastieri, D. A1 - Becerra Gonzalez, J. A1 - Bednarek, W. A1 - Berdyugin, A. A1 - Berger, K. A1 - Bernardini, E. A1 - Biland, A. A1 - Blanch Bigas, O. A1 - Bock, R. K. A1 - Boller, A. A1 - Bonnoli, G. A1 - Tridon, D. Borla A1 - Braun, I. A1 - Bretz, T. A1 - Canellas, A. A1 - Carmona, E. A1 - Carosi, A. A1 - Colin, P. A1 - Colombo, E. A1 - Contreras, J. L. A1 - Cortina, J. A1 - Cossio, L. A1 - Covino, S. A1 - Dazzi, F. A1 - De Angelis, A. A1 - De Cea del Pozo, E. A1 - De Lotto, B. A1 - Delgado Mendez, C. A1 - Diago Ortega, A. A1 - Doert, M. A1 - Dominguez, A. A1 - Prester, Dijana Dominis A1 - Dorner, D. A1 - Doro, M. A1 - Elsaesser, D. A1 - Ferenc, D. A1 - Fonseca, M. V. A1 - Font, L. A1 - Fruck, C. A1 - Garcia Lopez, R. J. A1 - Garczarczyk, M. A1 - Garrido, D. A1 - Giavitto, G. A1 - Godinovic, N. A1 - Hadasch, D. A1 - Haefner, D. A1 - Herrero, A. A1 - Hildebrand, D. A1 - Hoehne-Moench, D. A1 - Hose, J. A1 - Hrupec, D. A1 - Huber, B. A1 - Jogler, T. A1 - Klepser, S. A1 - Kraehenbuehl, T. A1 - Krause, J. A1 - La Barbera, A. A1 - Lelas, D. A1 - Leonardo, E. A1 - Lindfors, E. A1 - Lombardi, S. A1 - Lopez, M. A1 - Lorenz, E. A1 - Makariev, M. A1 - Maneva, G. A1 - Mankuzhiyil, N. A1 - Mannheim, K. A1 - Maraschi, L. A1 - Mariotti, M. A1 - Martinez, M. A1 - Mazin, D. A1 - Meucci, M. A1 - Miranda, J. M. A1 - Mirzoyan, R. A1 - Miyamoto, H. A1 - Moldon, J. A1 - Moralejo, A. A1 - Munar, P. A1 - Nieto, D. A1 - Nilsson, K. A1 - Orito, R. A1 - Oya, I. A1 - Paneque, D. A1 - Paoletti, R. A1 - Pardo, S. A1 - Paredes, J. M. A1 - Partini, S. A1 - Pasanen, M. A1 - Pauss, F. A1 - Perez-Torres, M. A. A1 - Persic, M. A1 - Peruzzo, L. A1 - Pilia, M. A1 - Pochon, J. A1 - Prada, F. A1 - Moroni, P. G. Prada A1 - Prandini, E. A1 - Puljak, I. A1 - Reichardt, I. A1 - Reinthal, R. A1 - Rhode, W. A1 - Ribo, M. A1 - Rico, J. A1 - Ruegamer, S. A1 - Saggion, A. A1 - Saito, K. A1 - Saito, T. Y. A1 - Salvati, M. A1 - Satalecka, K. A1 - Scalzotto, V. A1 - Scapin, V. A1 - Schultz, C. A1 - Schweizer, T. A1 - Shayduk, M. A1 - Shore, S. N. A1 - Sillanpaa, A. A1 - Sitarek, J. A1 - Sobczynska, D. A1 - Spanier, F. A1 - Spiro, S. A1 - Stamerra, A. A1 - Steinke, B. A1 - Storz, J. A1 - Strah, N. A1 - Suric, T. A1 - Takalo, L. A1 - Takami, H. A1 - Tavecchio, F. A1 - Temnikov, P. A1 - Terzic, T. A1 - Tescaro, D. A1 - Teshima, M. A1 - Thom, M. A1 - Tibolla, O. A1 - Torres, D. F. A1 - Treves, A. A1 - Vankov, H. A1 - Vogler, P. A1 - Wagner, R. M. A1 - Weitzel, Q. A1 - Zabalza, V. A1 - Zandanel, F. A1 - Zanin, R. A1 - Arlen, T. A1 - Aune, T. A1 - Beilicke, M. A1 - Benbow, W. A1 - Bouvier, A. A1 - Bradbury, S. M. A1 - Buckley, J. H. A1 - Bugaev, V. A1 - Byrum, K. A1 - Cannon, A. A1 - Cesarini, A. A1 - Ciupik, L. A1 - Connolly, M. P. A1 - Cui, W. A1 - Dickherber, R. A1 - Duke, C. A1 - Errando, M. A1 - Falcone, A. A1 - Finley, J. P. A1 - Finnegan, G. A1 - Fortson, L. A1 - Furniss, A. A1 - Galante, N. A1 - Gall, D. A1 - Godambe, S. A1 - Griffin, S. A1 - Grube, J. A1 - Gyuk, G. A1 - Hanna, D. A1 - Holder, J. A1 - Huan, H. A1 - Hui, C. M. A1 - Kaaret, P. A1 - Karlsson, N. A1 - Kertzman, M. A1 - Khassen, Y. A1 - Kieda, D. A1 - Krawczynski, H. A1 - Krennrich, F. A1 - Lang, M. J. A1 - LeBohec, S. A1 - Maier, G. A1 - McArthur, S. A1 - McCann, A. A1 - Moriarty, P. A1 - Mukherjee, R. A1 - Nunez, P. D. A1 - Ong, R. A. A1 - Orr, M. A1 - Otte, A. N. A1 - Park, N. A1 - Perkins, J. S. A1 - Pichel, A. A1 - Pohl, Martin A1 - Prokoph, H. A1 - Ragan, K. A1 - Reyes, L. C. A1 - Reynolds, P. T. A1 - Roache, E. A1 - Rose, H. J. A1 - Ruppel, J. A1 - Schroedter, M. A1 - Sembroski, G. H. A1 - Sentuerk, G. D. A1 - Telezhinsky, Igor O. A1 - Tesic, G. A1 - Theiling, M. A1 - Thibadeau, S. A1 - Varlotta, A. A1 - Vassiliev, V. V. A1 - Vivier, M. A1 - Wakely, S. P. A1 - Weekes, T. C. A1 - Williams, D. A. A1 - Zitzer, B. A1 - de Almeida, U. Barres A1 - Cara, M. A1 - Casadio, C. A1 - Cheung, C. C. A1 - McConville, W. A1 - Davies, F. A1 - Doi, A. A1 - Giovannini, G. A1 - Giroletti, M. A1 - Hada, K. A1 - Hardee, P. A1 - Harris, D. E. A1 - Junor, W. A1 - Kino, M. A1 - Lee, N. P. A1 - Ly, C. A1 - Madrid, J. A1 - Massaro, F. A1 - Mundell, C. G. A1 - Nagai, H. A1 - Perlman, E. S. A1 - Steele, I. A. A1 - Walker, R. C. A1 - Wood, D. L. T1 - The 2010 very high energy gamma-ray flare and 10 years ofmulti-wavelength oservations of M 87 JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - The giant radio galaxy M 87 with its proximity (16 Mpc), famous jet, and very massive black hole ((3-6) x 10(9) M-circle dot) provides a unique opportunity to investigate the origin of very high energy (VHE; E > 100 GeV) gamma-ray emission generated in relativistic outflows and the surroundings of supermassive black holes. M 87 has been established as a VHE gamma-ray emitter since 2006. The VHE gamma-ray emission displays strong variability on timescales as short as a day. In this paper, results from a joint VHE monitoring campaign on M 87 by the MAGIC and VERITAS instruments in 2010 are reported. During the campaign, a flare at VHE was detected triggering further observations at VHE (H.E.S.S.), X-rays (Chandra), and radio (43 GHz Very Long Baseline Array, VLBA). The excellent sampling of the VHE gamma-ray light curve enables one to derive a precise temporal characterization of the flare: the single, isolated flare is well described by a two-sided exponential function with significantly different flux rise and decay times of tau(rise)(d) = (1.69 +/- 0.30) days and tau(decay)(d) = (0.611 +/- 0.080) days, respectively. While the overall variability pattern of the 2010 flare appears somewhat different from that of previous VHE flares in 2005 and 2008, they share very similar timescales (similar to day), peak fluxes (Phi(>0.35 TeV) similar or equal to (1-3) x 10(-11) photons cm(-2) s(-1)), and VHE spectra. VLBA radio observations of 43 GHz of the inner jet regions indicate no enhanced flux in 2010 in contrast to observations in 2008, where an increase of the radio flux of the innermost core regions coincided with a VHE flare. On the other hand, Chandra X-ray observations taken similar to 3 days after the peak of the VHE gamma-ray emission reveal an enhanced flux from the core (flux increased by factor similar to 2; variability timescale <2 days). The long-term (2001-2010) multi-wavelength (MWL) light curve of M 87, spanning from radio to VHE and including data from Hubble Space Telescope, Liverpool Telescope, Very Large Array, and European VLBI Network, is used to further investigate the origin of the VHE gamma-ray emission. No unique, common MWL signature of the three VHE flares has been identified. In the outer kiloparsec jet region, in particular in HST-1, no enhanced MWL activity was detected in 2008 and 2010, disfavoring it as the origin of the VHE flares during these years. Shortly after two of the three flares (2008 and 2010), the X-ray core was observed to be at a higher flux level than its characteristic range (determined from more than 60 monitoring observations: 2002-2009). In 2005, the strong flux dominance of HST-1 could have suppressed the detection of such a feature. Published models for VHE gamma-ray emission from M 87 are reviewed in the light of the new data. KW - galaxies: active KW - galaxies: individual (M 87) KW - galaxies: jets KW - galaxies: nuclei KW - gamma rays: galaxies KW - radiation mechanisms: non-thermal Y1 - 2012 U6 - https://doi.org/10.1088/0004-637X/746/2/151 SN - 0004-637X VL - 746 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Voigt-Zimmermann, Susanne A1 - Stier, Karl-Heinz A1 - Lascheit, Thomas A1 - Kruse, Stephanie A. A1 - Blickensdorff, Maria A1 - Förster, Theresa A1 - Schumacher, Rebecca A1 - Burchert, Frank A1 - Ablinger, Irene A1 - Förster, Christine A1 - Wahl, Michael A1 - Schirmacher, Irene A1 - Ostermann, Frank A1 - Welke, Lisa-Marie A1 - Frank, Ulrike A1 - Zakariás, Lilla A1 - Salis, Christos A1 - Wartenburger, Isabell A1 - Krug, Ragna A1 - Stübner, Hanna A1 - Hoffmann, Sophie A1 - Heide, Judith ED - Fritzsche, Tom ED - Yetim, Özlem ED - Otto, Constanze ED - Adelt, Anne T1 - Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie N2 - Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Hauptvorträge zum Schwerpunktthema sowie Beiträge zu den Kurzvorträgen »Spektrum Patholinguistik« und der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Eleventh Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Well tuned: Diagnostics and therapy in dysphonia« took place in Potsdam on November 18 2017. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the keynote talks on the main topic as well as contributions from the short talks in the section »Spectrum Patholinguistics« and from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 11 KW - Patholinguistik KW - Sprachtherapie KW - Stimmtherapie KW - Stimmstörung KW - Dysphonie KW - patholinguistics KW - speech/language therapy KW - voice therapy KW - dysphonia Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-418574 SN - 978-3-86956-448-7 SN - 1866-9085 SN - 1866-9433 IS - 11 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Arnold, Rafael A1 - Balla, Zsolt A1 - Cohen, Susan A1 - Conway-Jones, Ann A1 - Dallapiazza, Michael A1 - Denz, Rebekka A1 - Freud-Kandel, Miri A1 - Griffiths, Toni A1 - Grözinger, Elvira A1 - Himmelmann, Werner A1 - Hiscott, William A1 - Hoffmann, Daniel A1 - Horch, Hans-Otto A1 - Kellner-Rauch, Heike A1 - Lehnguth, Cornelius A1 - Martini, Annett A1 - Pella, Sebastian A1 - Rosner, Anna A1 - Szulc, Michał A1 - Wurbs, Janina A1 - Wynn, Natalie ED - Denz, Rebekka ED - Jurewicz, Grażyna ED - Salzer, Dorothea M. T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = Einblicke in die ‚British Jewish Studies‘ T1 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = Insight into ‘British Jewish Studies’ N2 - PaRDeS. Zeitschrift der Vereinigung für Jüdische Studien e. V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung. N2 - PaRDeS. Journal of the Association of Jewish Studies e. V. The journal aims at documenting the fruitful and multifarious culture of Judaism as well as its relations to its environment within diverse areas of research. In addition, the journal is meant to promote Jewish Studies within academic discourse and discuss its historic and social responsibility. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 18 Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-59255 SN - 978-3-86956-177-6 SN - 1614-6492 SN - 1862-7684 IS - 18 PB - Universitätsverlag Potsdam CY - Potsdam ER -