TY - JOUR
A1 - Puerto Valencia, Laura Maria
A1 - Arampatzis, Adamantios
A1 - Beck, Heidrun
A1 - Dreinhöfer, Karsten E.
A1 - Drießlein, Drießlein
A1 - Mau, Wilfried
A1 - Zimmer, Julia-Marie
A1 - Schäfer, Michael
A1 - Steinfeldt, Friedemann
A1 - Wippert, Pia-Maria
T1 - RENaBack: Low back pain patients in rehabilitation: Study Protocol for a Multicenter, Randomized Controlled Trial
JF - Trials
N2 - Background
Millions of people in Germany suffer from chronic pain, in which course and intensity are multifactorial. Besides physical injuries, certain psychosocial risk factors are involved in the disease process. The national health care guidelines for the diagnosis and treatment of non-specific low back pain recommend the screening of psychosocial risk factors as early as possible, to be able to adapt the therapy to patient needs (e.g., unimodal or multimodal). However, such a procedure has been difficult to implement in practice and has not yet been integrated into the rehabilitation care structures across the country.
Methods
The aim of this study is to implement an individualized therapy and aftercare program within the rehabilitation offer of the German Pension Insurance in the area of orthopedics and to examine its success and sustainability in comparison to the previous standard aftercare program.
The study is a multicenter randomized controlled trial including 1204 patients from six orthopedic rehabilitation clinics. A 2:1 allocation ratio to intervention (individualized and home-based rehabilitation aftercare) versus the control group (regular outpatient rehabilitation aftercare) is set. Upon admission to the rehabilitation clinic, participants in the intervention group will be screened according to their psychosocial risk profile. They could then receive either unimodal or multimodal, together with an individualized training program. The program is instructed in the clinic (approximately 3 weeks) and will continue independently at home afterwards for 3 months. The success of the program is examined by means of a total of four surveys. The co-primary outcomes are the Characteristic Pain Intensity and Disability Score assessed by the German version of the Chronic Pain Grade questionnaire (CPG).
Discussion
An improvement in terms of pain, work ability, patient compliance, and acceptance in our intervention program compared to the standard aftercare is expected. The study contributes to provide individualized care also to patients living far away from clinical centers.
Trial registration
DRKS, DRKS00020373. Registered on 15 April 2020
KW - Chronic low back pain
KW - Aftercare
KW - Individualized therapy
KW - Randomized controlled trial
KW - Rehabilitation
Y1 - 2021
U6 - https://doi.org/10.1186/s13063-021-05823-3
SN - 1745-6215
SP - 1
EP - 18
PB - Springer Nature / BMC
CY - Heidelberg
ER -
TY - GEN
A1 - Puerto Valencia, Laura Maria
A1 - Arampatzis, Adamantios
A1 - Beck, Heidrun
A1 - Dreinhöfer, Karsten E.
A1 - Drießlein, Drießlein
A1 - Mau, Wilfried
A1 - Zimmer, Julia-Marie
A1 - Schäfer, Michael
A1 - Steinfeldt, Friedemann
A1 - Wippert, Pia-Maria
T1 - RENaBack: Low back pain patients in rehabilitation: Study Protocol for a Multicenter, Randomized Controlled Trial
T2 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - Background
Millions of people in Germany suffer from chronic pain, in which course and intensity are multifactorial. Besides physical injuries, certain psychosocial risk factors are involved in the disease process. The national health care guidelines for the diagnosis and treatment of non-specific low back pain recommend the screening of psychosocial risk factors as early as possible, to be able to adapt the therapy to patient needs (e.g., unimodal or multimodal). However, such a procedure has been difficult to implement in practice and has not yet been integrated into the rehabilitation care structures across the country.
Methods
The aim of this study is to implement an individualized therapy and aftercare program within the rehabilitation offer of the German Pension Insurance in the area of orthopedics and to examine its success and sustainability in comparison to the previous standard aftercare program.
The study is a multicenter randomized controlled trial including 1204 patients from six orthopedic rehabilitation clinics. A 2:1 allocation ratio to intervention (individualized and home-based rehabilitation aftercare) versus the control group (regular outpatient rehabilitation aftercare) is set. Upon admission to the rehabilitation clinic, participants in the intervention group will be screened according to their psychosocial risk profile. They could then receive either unimodal or multimodal, together with an individualized training program. The program is instructed in the clinic (approximately 3 weeks) and will continue independently at home afterwards for 3 months. The success of the program is examined by means of a total of four surveys. The co-primary outcomes are the Characteristic Pain Intensity and Disability Score assessed by the German version of the Chronic Pain Grade questionnaire (CPG).
Discussion
An improvement in terms of pain, work ability, patient compliance, and acceptance in our intervention program compared to the standard aftercare is expected. The study contributes to provide individualized care also to patients living far away from clinical centers.
Trial registration
DRKS, DRKS00020373. Registered on 15 April 2020
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 772
KW - Chronic low back pain
KW - Aftercare
KW - Individualized therapy
KW - Randomized controlled trial
KW - Rehabilitation
Y1 - 2022
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-554683
SN - 1866-8364
SP - 1
EP - 18
PB - Universitätsverlag Potsdam
CY - Potsdam
ER -
TY - GEN
A1 - Heinz, Andreas
A1 - Kiefer, Falk
A1 - Smolka, Michael N.
A1 - Endrass, Tanja
A1 - Beste, Christian
A1 - Beck, Anne
A1 - Liu, Shuyan
A1 - Genauck, Alexander
A1 - Romund, Lydia
A1 - Rapp, Michael Armin
A1 - Tost, Heike
A1 - Spanagel, Rainer
T1 - Addiction research consortium: losing and regaining control over drug intake (ReCoDe) - from trajectories to mechanisms and interventions
T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 727
KW - addiction
KW - alternative rewards
KW - animal and computational models
KW - cognitive-behavioral control
KW - craving and relapse
KW - habit formation
Y1 - 2019
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-525972
SN - 1866-8364
IS - 2
ER -
TY - JOUR
A1 - Heinz, Andreas
A1 - Kiefer, Falk
A1 - Smolka, Michael N.
A1 - Endrass, Tanja
A1 - Beste, Christian
A1 - Beck, Anne
A1 - Liu, Shuyan
A1 - Genauck, Alexander
A1 - Romund, Lydia
A1 - Rapp, Michael Armin
A1 - Tost, Heike
A1 - Spanagel, Rainer
T1 - Addiction research consortium: losing and regaining control over drug intake (ReCoDe) - from trajectories to mechanisms and interventions
JF - Addiction Biology
N2 - One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
KW - addiction
KW - alternative rewards
KW - animal and computational models
KW - cognitive-behavioral control
KW - craving and relapse
KW - habit formation
Y1 - 2019
VL - 25
IS - 2
PB - John Wiley & Sons, Inc.
CY - New Jersey
ER -
TY - JOUR
A1 - Seitz, Aaron P.
A1 - Schumacher, Fabian
A1 - Baker, Jennifer
A1 - Soddemann, Matthias
A1 - Wilker, Barbara
A1 - Caldwell, Charles C.
A1 - Gobble, Ryan M.
A1 - Kamler, Markus
A1 - Becker, Katrin Anne
A1 - Beck, Sascha
A1 - Kleuser, Burkhard
A1 - Edwards, Michael J.
A1 - Gulbins, Erich
T1 - Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
JF - Journal of molecular medicine
N2 - Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by developing a novel method of coating surfaces of endotracheal tubes with sphingosine and sphingosine analogs. Sphingosine and phytosphingosine coatings of endotracheal tubes prevent adherence and mediate killing of Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, even in biofilms. Most importantly, sphingosine-coating of endotracheal tubes also prevented P. aeruginosa and S. aureus pneumonia in vivo. Coating of the tubes with sphingosine was stable, without obvious side effects on tracheal epithelial cells and did not induce inflammation. In summary, we describe a novel method to coat plastic surfaces and provide evidence for the application of sphingosine and phytosphingosine as novel antimicrobial coatings to prevent bacterial adherence and induce killing of pathogens on the surface of endotracheal tubes with potential to prevent biofilm formation and VAP.Key messagesNovel dip-coating method to coat plastic surfaces with lipids.Sphingosine and phytosphingosine as novel antimicrobial coatings on plastic surface.Sphingosine coatings of endotracheal tubes prevent bacterial adherence and biofilms.Sphingosine coatings of endotracheal tubes induce killing of pathogens.Sphingosine coatings of endotracheal tubes ventilator-associated pneumonia.
KW - Coating
KW - Plastic surfaces
KW - Sphingosine
KW - Ventilation
KW - Acinetobacter baumannii
KW - Pseudomonas aeruginosa
KW - Staphylococcus aureus
Y1 - 2019
U6 - https://doi.org/10.1007/s00109-019-01800-1
SN - 0946-2716
SN - 1432-1440
VL - 97
IS - 8
SP - 1195
EP - 1211
PB - Springer
CY - Heidelberg
ER -
TY - JOUR
A1 - Schad, Daniel
A1 - Garbusow, Maria
A1 - Friedel, Eva
A1 - Sommer, Christian
A1 - Sebold, Miriam Hannah
A1 - Hägele, Claudia
A1 - Bernhardt, Nadine
A1 - Nebe, Stephan
A1 - Kuitunen-Paul, Sören
A1 - Liu, Shuyan
A1 - Eichmann, Uta
A1 - Beck, Anne
A1 - Wittchen, Hans-Ulrich
A1 - Walter, Henrik
A1 - Sterzer, Philipp
A1 - Zimmermann, Ulrich S.
A1 - Smolka, Michael N.
A1 - Schlagenhauf, Florian
A1 - Huys, Quentin J. M.
A1 - Heinz, Andreas
A1 - Rapp, Michael Armin
T1 - Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk
JF - European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
N2 - The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = -3.86, p < .001), but not in healthy controls (t = -0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t((30)) = 2.06, p < .05). Interestingly, both the effects were only present in subsequent abstainers, but not relapsers and in those with mild but not severe dependence. Our data show that alcohol-related cues can acquire inhibitory behavioral features typical of aversive stimuli despite being accompanied by a stronger NAcc activation, suggesting salience attribution. The fact that these findings are restricted to abstinence and milder illness suggests that they may be potential resilience factors.
KW - Alcohol dependence
KW - Human neuroimaging
KW - Nucleus accumbens
KW - Pavlovian-instrumental transfer
KW - Relapse
Y1 - 2018
U6 - https://doi.org/10.1007/s00406-017-0860-4
SN - 0940-1334
SN - 1433-8491
VL - 269
IS - 3
SP - 295
EP - 308
PB - Springer
CY - Heidelberg
ER -
TY - JOUR
A1 - Balta Beylergil, Sinem
A1 - Beck, Anne
A1 - Deserno, Lorenz
A1 - Lorenz, Robert C.
A1 - Rapp, Michael Armin
A1 - Schlagenhauf, Florian
A1 - Heinz, Andreas
A1 - Obermayer, Klaus
T1 - Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence
JF - NeuroImage: Clinical : a journal of diseases affecting the nervous system
N2 - Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the “double-update” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.
KW - Alcohol dependence
KW - Prediction error
KW - Reinforcement learning
KW - Reversal learning
KW - Dorsolateral prefrontal cortex
KW - Decision-making
Y1 - 2017
U6 - https://doi.org/10.1016/j.nicl.2017.04.010
SN - 2213-1582
VL - 15
SP - 80
EP - 94
PB - Elsevier
CY - Oxford
ER -
TY - JOUR
A1 - Sebold, Miriam Hannah
A1 - Nebe, Stephan
A1 - Garbusow, Maria
A1 - Guggenmos, Matthias
A1 - Schad, Daniel
A1 - Beck, Anne
A1 - Kuitunen-Paul, Sören
A1 - Sommer, Christian
A1 - Frank, Robin
A1 - Neu, Peter
A1 - Zimmermann, Ulrich S.
A1 - Rapp, Michael Armin
A1 - Smolka, Michael N.
A1 - Huys, Quentin J. M.
A1 - Schlagenhauf, Florian
A1 - Heinz, Andreas
T1 - When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence
JF - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
N2 - BACKGROUND: Addiction is supposedly characterized by a shift from goal-directed to habitual decision making, thus facilitating automatic drug intake. The two-step task allows distinguishing between these mechanisms by computationally modeling goal-directed and habitual behavior as model-based and model-free control. In addicted patients, decision making may also strongly depend upon drug-associated expectations. Therefore, we investigated model-based versus model-free decision making and its neural correlates as well as alcohol expectancies in alcohol-dependent patients and healthy controls and assessed treatment outcome in patients. METHODS: Ninety detoxified, medication-free, alcohol-dependent patients and 96 age-and gender-matched control subjects underwent functional magnetic resonance imaging during the two-step task. Alcohol expectancies were measured with the Alcohol Expectancy Questionnaire. Over a follow-up period of 48 weeks, 37 patients remained abstinent and 53 patients relapsed as indicated by the Alcohol Timeline Followback method. RESULTS: Patients who relapsed displayed reduced medial prefrontal cortex activation during model-based decision making. Furthermore, high alcohol expectancies were associated with low model-based control in relapsers, while the opposite was observed in abstainers and healthy control subjects. However, reduced model-based control per se was not associated with subsequent relapse. CONCLUSIONS: These findings suggest that poor treatment outcome in alcohol dependence does not simply result from a shift from model-based to model-free control but is instead dependent on the interaction between high drug expectancies and low model-based decision making. Reduced model-based medial prefrontal cortex signatures in those who relapse point to a neural correlate of relapse risk. These observations suggest that therapeutic interventions should target subjective alcohol expectancies.
KW - Alcohol dependence
KW - Alcohol expectancy
KW - Goal-directed control
KW - Medial prefrontal cortex
KW - Reinforcement learning
KW - Treatment outcome
Y1 - 2017
U6 - https://doi.org/10.1016/j.biopsych.2017.04.019
SN - 0006-3223
SN - 1873-2402
VL - 82
SP - 847
EP - 856
PB - Elsevier
CY - New York
ER -
TY - GEN
A1 - Heinz, Andreas
A1 - Beck, Anne
A1 - Rapp, Michael Armin
T1 - Alcohol as an Environmental Mortality Hazard
T2 - JAMA psychiatry
Y1 - 2016
U6 - https://doi.org/10.1001/jamapsychiatry.2016.0399
SN - 2168-622X
SN - 2168-6238
VL - 73
SP - 549
EP - 550
PB - American Veterinary Medical Association
CY - Chicago
ER -
TY - JOUR
A1 - Deserno, Lorenz
A1 - Beck, Anne
A1 - Huys, Quentin J. M.
A1 - Lorenz, Robert C.
A1 - Buchert, Ralph
A1 - Buchholz, Hans-Georg
A1 - Plotkin, Michail
A1 - Kumakara, Yoshitaka
A1 - Cumming, Paul
A1 - Heinze, Hans-Jochen
A1 - Grace, Anthony A.
A1 - Rapp, Michael Armin
A1 - Schlagenhauf, Florian
A1 - Heinz, Andreas
T1 - Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum
JF - European journal of neuroscience
N2 - Drugs of abuse elicit dopamine release in the ventral striatum, possibly biasing dopamine-driven reinforcement learning towards drug-related reward at the expense of non-drug-related reward. Indeed, in alcohol-dependent patients, reactivity in dopaminergic target areas is shifted from non-drug-related stimuli towards drug-related stimuli. Such hijacked' dopamine signals may impair flexible learning from non-drug-related rewards, and thus promote craving for the drug of abuse. Here, we used functional magnetic resonance imaging to measure ventral striatal activation by reward prediction errors (RPEs) during a probabilistic reversal learning task in recently detoxified alcohol-dependent patients and healthy controls (N=27). All participants also underwent 6-[F-18]fluoro-DOPA positron emission tomography to assess ventral striatal dopamine synthesis capacity. Neither ventral striatal activation by RPEs nor striatal dopamine synthesis capacity differed between groups. However, ventral striatal coding of RPEs correlated inversely with craving in patients. Furthermore, we found a negative correlation between ventral striatal coding of RPEs and dopamine synthesis capacity in healthy controls, but not in alcohol-dependent patients. Moderator analyses showed that the magnitude of the association between dopamine synthesis capacity and RPE coding depended on the amount of chronic, habitual alcohol intake. Despite the relatively small sample size, a power analysis supports the reported results. Using a multimodal imaging approach, this study suggests that dopaminergic modulation of neural learning signals is disrupted in alcohol dependence in proportion to long-term alcohol intake of patients. Alcohol intake may perpetuate itself by interfering with dopaminergic modulation of neural learning signals in the ventral striatum, thus increasing craving for habitual drug intake.
KW - alcohol addiction
KW - dopamine
KW - fMRI
KW - PET
KW - prediction error
Y1 - 2015
U6 - https://doi.org/10.1111/ejn.12802
SN - 0953-816X
SN - 1460-9568
VL - 41
IS - 4
SP - 477
EP - 486
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Haegele, Claudia
A1 - Schlagenhauf, Florian
A1 - Rapp, Michael Armin
A1 - Sterzer, Philipp
A1 - Beck, Anne
A1 - Bermpohl, Felix
A1 - Stoy, Meline
A1 - Stroehle, Andreas
A1 - Wittchen, Hans-Ulrich
A1 - Dolan, Raymond J.
A1 - Heinz, Andreas
T1 - Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders
JF - Psychopharmacology
N2 - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
KW - Dimensional
KW - fMRI
KW - Reward system
KW - Ventral striatum
KW - Monetary incentive delay task
KW - Depressive symptoms
Y1 - 2015
U6 - https://doi.org/10.1007/s00213-014-3662-7
SN - 0033-3158
SN - 1432-2072
VL - 232
IS - 2
SP - 331
EP - 341
PB - Springer
CY - New York
ER -
TY - JOUR
A1 - Friedel, Eva
A1 - Schlagenhauf, Florian
A1 - Beck, Anne
A1 - Dolan, Raymond J.
A1 - Huys, Quentin J. M.
A1 - Rapp, Michael Armin
A1 - Heinz, Andreas
T1 - The effects of life stress and neural learning signals on fluid intelligence
JF - European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry
N2 - Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.
KW - Reinforcement learning
KW - Prediction error signal
KW - Ventral striatum
KW - Stress
KW - Intelligence
Y1 - 2015
U6 - https://doi.org/10.1007/s00406-014-0519-3
SN - 0940-1334
SN - 1433-8491
VL - 265
IS - 1
SP - 35
EP - 43
PB - Springer
CY - Heidelberg
ER -
TY - GEN
A1 - Hägele, Claudia
A1 - Schlagenhauf, Florian
A1 - Rapp, Michael Armin
A1 - Sterzer, Philipp
A1 - Beck, Anne
A1 - Bermpohl, Felix
A1 - Stoy, Meline
A1 - Ströhle, Andreas
A1 - Wittchen, Hans-Ulrich
A1 - Dolan, Raymond J.
A1 - Heinz, Andreas
T1 - Dimensional psychiatry
BT - reward dysfunction and depressive mood across psychiatric disorders
T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries.
We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment.
We used functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task to study the functional correlates of reward anticipation across major psychiatric disorders in 184 subjects, with the diagnoses of alcohol dependence (n = 26), schizophrenia (n = 44), major depressive disorder (MDD, n = 24), bipolar disorder (acute manic episode, n = 13), attention deficit/hyperactivity disorder (ADHD, n = 23), and healthy controls (n = 54). Subjects' individual Beck Depression Inventory-and State-Trait Anxiety Inventory-scores were correlated with clusters showing significant activation during reward anticipation.
During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation.
Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 653
KW - dimensional
KW - fMRI
KW - reward system
KW - ventral striatum
KW - monetary incentive delay task
KW - depressive symptoms
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431064
SN - 1866-8364
IS - 653
SP - 331
EP - 341
ER -
TY - GEN
A1 - Friedel, Eva
A1 - Schlagenhauf, Florian
A1 - Beck, Anne
A1 - Dolan, Raymond J.
A1 - Huys, Quentin J. M.
A1 - Rapp, Michael Armin
A1 - Heinz, Andreas
T1 - The effects of life stress and neural learning signals on fluid intelligence
T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2 - Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 621
KW - reinforcement learning
KW - prediction error signal
KW - ventral striatum
KW - stress
KW - intelligence
Y1 - 2020
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435140
SN - 1866-8372
IS - 621
SP - 35
EP - 43
ER -
TY - CHAP
A1 - Haegele, Claudia
A1 - Friedel, Eva
A1 - Schlagenhauf, Florian
A1 - Sterzer, Philipp
A1 - Beck, Anne
A1 - Bermpohl, Felix
A1 - Rapp, Michael Armin
A1 - Stoy, Meline
A1 - Stroehle, Andreas
A1 - Dolan, Raymond J.
A1 - Heinz, Andreas
T1 - Reward expectation and affective responses across psychiatric disorders - A dimensional approach
T2 - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry
KW - dimensional
KW - transdiagnostic
KW - reward system
KW - ventral striatum
KW - fMRI
Y1 - 2014
SN - 0006-3223
SN - 1873-2402
VL - 75
IS - 9
SP - 91S
EP - 92S
PB - Elsevier
CY - New York
ER -
TY - JOUR
A1 - Lorenz, Robert C.
A1 - Gleich, Tobias
A1 - Beck, Anne
A1 - Poehland, Lydia
A1 - Raufelder, Diana
A1 - Sommer, Werner
A1 - Rapp, Michael Armin
A1 - Kuehn, Simone
A1 - Gallinat, Jürgen
T1 - Reward anticipation in the adolescent and aging brain
JF - Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging
N2 - Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions. Hum Brain Mapp 35:5153-5165, 2014. (c) 2014 Wiley Periodicals, Inc.
KW - reward anticipation
KW - lifespan
KW - aging
KW - adolescence
KW - fMRI
KW - connectivity
Y1 - 2014
U6 - https://doi.org/10.1002/hbm.22540
SN - 1065-9471
SN - 1097-0193
VL - 35
IS - 10
SP - 5153
EP - 5165
PB - Wiley-Blackwell
CY - Hoboken
ER -
TY - JOUR
A1 - Sellrie, Frank
A1 - Beck, Michael
A1 - Hildebrandt, Niko
A1 - Micheel, Burkhard
T1 - A homogeneous time-resolved fluoroimmunoassay (TR-FIA) using antibody mediated luminescence quenching
N2 - The determination of low-molecular weight substances (haptens) is demonstrated with a homogeneous time-resolved immunoassay using antibody-induced luminescence quenching. Our novel assay technology uses the newly developed monoclonal antibody (G24-BA9) to quench the luminescence of europium trisbipyridine (EuTBP). We performed a competitive biotin immunoassay including an EuTBP-biotin conjugate, the anti-EuTBP antibody G24-BA9 and streptavidin as assay components. Steric hindrance allows only the binding of either G24-BA9 (to the EuTBP moiety) or streptavidin (to the biotin moiety) to the EuTBP-biotin conjugate. Addition of the analyte biotin resulted in the binding of streptavidin to biotin and a concomitant preferred binding of G24-BA9 to EuTBP-biotin. Since G24-BA9 quenches the luminescence of EuTBP within the conjugate, the luminescence signal could be used to indicate and quantify the presence of free biotin in the system. All experiments were carried out in solution in the presence of 5% serum demonstrating the possibility of using our novel assay for a very fast determination of low molecular weight substances in biological fluids.
Y1 - 2010
UR - http://www.rsc.org/Publishing/Journals/AY/Index.asp
U6 - https://doi.org/10.1039/C0ay00306a
SN - 1759-9660
ER -
TY - JOUR
A1 - Legall, Herbert
A1 - Stiel, Holger
A1 - Beck, Michael
A1 - Leupold, Dieter
A1 - Gruszecki, Wieslaw I.
A1 - Lokstein, Heiko
T1 - Near edge X-ray absorption fine structure spectroscopy (NEXAFS) of pigment-protein complexes : peridinin- chlorophyll a-protein (PCP) of Amphidinium carterae
N2 - Peridinin-chlorophyll a protein (PCP) is a unique water soluble antenna complex that employs the carotenoid peridinin as the main light-harvesting pigment. In the present study the near edge X-ray absorption fine structure (NEXAFS) spectrum of PCP was recorded at the carbon Kedge. Additionally, the NEXAFS spectra of the constituent pigments, chlorophyll a and peridinin, were measured. The energies of the lowest unoccupied molecular levels of these pigments appearing in the carbon NEXAFS spectrum were resolved. Individual contributions of the pigments and the protein to the measured NEXAFS spectrum of PCP were determined using a "building block" approach combining NEXAFS spectra of the pigments and the amino acids constituting the PCP apoprotein. The results suggest that absorption changes of the pigments in the carbon near K-edge region can be resolved following excitation using a suitable visible pump laser pulse. Consequently, it may be possible to study excitation energy transfer processes involving "optically dark" states of carotenoids in pigment-protein complexes by soft X-ray probe optical pump double resonance spectroscopy (XODR).
Y1 - 2007
UR - http://www.sciencedirect.com/science/journal/0165022X
U6 - https://doi.org/10.1016/j.jbbm.2006.08.005
SN - 0165-022X
ER -
TY - GEN
A1 - Löhmannsröben, Hans-Gerd
A1 - Beck, Michael
A1 - Hildebrandt, Niko
A1 - Schmälzlin, Elmar
A1 - van Dongen, Joost T.
T1 - New challenges in biophotonics : laser-based fluoroimmuno analysis and in-vivo optical oxygen monitoring
N2 - Two examples of our biophotonic research utilizing nanoparticles are presented, namely laser-based fluoroimmuno analysis and in-vivo optical oxygen monitoring. Results of the work include significantly enhanced sensitivity of a homogeneous fluorescence immunoassay and markedly improved spatial resolution of oxygen gradients in root nodules of a legume species.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 018
KW - Sauerstoff
KW - Quantenpunkt
KW - Lumineszenz
KW - Immunoassay
KW - Energietransfer
KW - Fluoreszenz-Resonanz-Energie-Transfer
KW - Nanopartikel
KW - Lanthanoide
KW - Optode
KW - Förster Resonanz Energie Transfer
KW - Biophotonik
KW - biophotonics
KW - nanoparticles
KW - immunoassay
KW - oxygen
KW - optode
Y1 - 2006
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-10120
ER -
TY - GEN
A1 - Niederkrüger, Matthias
A1 - Salb, Christian
A1 - Beck, Michael
A1 - Hildebrandt, Niko
A1 - Löhmannsröben, Hans-Gerd
A1 - Marowsky, Gerd
T1 - Improvement of a fluorescence immunoassay with a compact diode-pumped solid state laser at 315 nm
N2 - We demonstrate the improvement of fluorescence immunoassay (FIA) diagnostics in deploying a newly developed compact diode-pumped solid state (DPSS) laser with emission at 315 nm. The laser is based on the quasi-three-level transition in Nd:YAG at 946 nm. The pulsed operation is either realized by an active Q-switch using an electro-optical device or by introduction of a Cr4+:YAG saturable absorber as passive Q-switch element. By extra-cavity second harmonic generation in different nonlinear crystal media we obtained blue light at 473 nm. Subsequent mixing of the fundamental and the second harmonic in a β-barium-borate crystal provided pulsed emission at 315 nm with up to 20 μJ maximum pulse energy and 17 ns pulse duration. Substitution of a nitrogen laser in a FIA diagnostics system by the DPSS laser succeeded in considerable improvement of the detection limit. Despite significantly lower pulse energies (7 μJ DPSS laser versus 150 μJ nitrogen laser), in preliminary investigations the limit of detection was reduced by a factor of three for a typical FIA.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 016
KW - Immunoassay
KW - Fluoreszenz-Resonanz-Energie-Transfer
KW - Neodym-YAG-Laser
KW - 946 nm
KW - 473 nm
KW - 315 nm
KW - gepulster DPSS Laser
KW - sättigbarer Absorber
KW - fluorescence immunoassay
KW - 946 nm
KW - 473 nm
KW - 315 nm
KW - pulsed DPSS laser
Y1 - 2006
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-10150
ER -
TY - GEN
A1 - Beck, Michael
A1 - Hildebrandt, Niko
A1 - Löhmannsröben, Hans-Gerd
T1 - Quantum dots as acceptors in FRET-assays containing serum
N2 - Quantum dots (QDs) are common as luminescing markers for imaging in biological applications because their optical properties seem to be inert against their surrounding solvent. This, together with broad and strong absorption bands and intense, sharp tuneable luminescence bands, makes them interesting candidates for methods utilizing Förster Resonance Energy Transfer (FRET), e. g. for sensitive homogeneous fluoroimmunoassays (FIA). In this work we demonstrate energy transfer from Eu3+-trisbipyridin (Eu-TBP) donors to CdSe-ZnS-QD acceptors in solutions with and without serum. The QDs are commercially available CdSe-ZnS core-shell particles emitting at 655 nm (QD655). The FRET system was achieved by the binding of the streptavidin conjugated donors with the biotin conjugated acceptors. After excitation of Eu-TBP and as result of the energy transfer, the luminescence of the QD655 acceptors also showed lengthened decay times like the donors. The energy transfer efficiency, as calculated from the decay times of the bound and the unbound components, amounted to 37%. The Förster-radius, estimated from the absorption and emission bands, was ca. 77 Å. The effective binding ratio, which not only depends on the ratio of binding pairs but also on unspecific binding, was obtained from the donor emission dependent on the concentration. As serum promotes unspecific binding, the overall FRET efficiency of the assay was reduced. We conclude that QDs are good substitutes for acceptors in FRET if combined with slow decay donors like Europium. The investigation of the influence of the serum provides guidance towards improving binding properties of QD assays.
T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 019
KW - Quantenpunkt
KW - Lumineszenz
KW - Serum
KW - Europium
KW - Immunoassay
KW - Energietransfer
KW - Fluoreszenz-Resonanz-Energie-Transfer
KW - Förster-Resonanz-Energie-Transfer
KW - Quantum Dot
KW - Luminescence
KW - Serum
KW - Europium
KW - Immunoassay
KW - Energy Transfer
KW - FRET
Y1 - 2006
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-9504
ER -
TY - JOUR
A1 - Hildebrandt, Niko
A1 - Charbonniere, Loïc J.
A1 - Beck, Michael
A1 - Ziessel, Raymond F.
A1 - Löhmannsröben, Hans-Gerd
T1 - Quantum dots as efficient energy acceptors in a time-resolved fluoroimmunoassay
Y1 - 2005
SN - 1433-7851
ER -
TY - JOUR
A1 - Gruszecki, Wieslaw I.
A1 - Stiel, H.
A1 - Niedzwiedzki, Dariusz
A1 - Beck, Michael
A1 - Milanowska, J.
A1 - Lokstein, Heiko
A1 - Leupold, Dieter
T1 - Towards elucidating the energy of the first excited singlet state of xanthophyll cycle pigments investigated by x-ray absorption spectroscopy
Y1 - 2005
ER -
TY - JOUR
A1 - Beck, Michael
A1 - Stiel, H.
A1 - Leupold, Dieter
A1 - Winter, Bernd
A1 - Pop, D.
A1 - Vogt, U.
A1 - Spitz, Christian
T1 - Evaluation of the energetic position of the lowest excited singlet state of ß-carotene by NEXAFS and photoemission spectroscopy
Y1 - 2001
ER -