TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - CHAP
A1  - Curzon, Paul
A1  - Kalas, Ivan
A1  - Schubert, Sigrid
A1  - Schaper, Niclas
A1  - Barnes, Jan
A1  - Kennewell, Steve
A1  - Bröker, Kathrin
A1  - Kastens, Uwe
A1  - Magenheim, Johannes
A1  - Dagiene, Valentina
A1  - Stupuriene, Gabriele
A1  - Ellis, Jason Brent
A1  - Abreu-Ellis, Carla Reis
A1  - Grillenberger, Andreas
A1  - Romeike, Ralf
A1  - Haugsbakken, Halvdan
A1  - Jones, Anthony
A1  - Lewin, Cathy
A1  - McNicol, Sarah
A1  - Nelles, Wolfgang
A1  - Neugebauer, Jonas
A1  - Ohrndorf, Laura
A1  - Schaper, Niclas
A1  - Schubert, Sigrid
A1  - Opel, Simone
A1  - Kramer, Matthias
A1  - Trommen, Michael
A1  - Pottbäcker, Florian
A1  - Ilaghef, Youssef
A1  - Passig, David
A1  - Tzuriel, David
A1  - Kedmi, Ganit Eshel
A1  - Saito, Toshinori
A1  - Webb, Mary
A1  - Weigend, Michael
A1  - Bottino, Rosa
A1  - Chioccariello, Augusto
A1  - Christensen, Rhonda
A1  - Knezek, Gerald
A1  - Gioko, Anthony Maina
A1  - Angondi, Enos Kiforo
A1  - Waga, Rosemary
A1  - Ohrndorf, Laura
A1  - Or-Bach, Rachel
A1  - Preston, Christina
A1  - Younie, Sarah
A1  - Przybylla, Mareen
A1  - Romeike, Ralf
A1  - Reynolds, Nicholas
A1  - Swainston, Andrew
A1  - Bendrups, Faye
A1  - Sysło, Maciej M.
A1  - Kwiatkowska, Anna Beata
A1  - Zieris, Holger
A1  - Gerstberger, Herbert
A1  - Müller, Wolfgang
A1  - Büchner, Steffen
A1  - Opel, Simone
A1  - Schiller, Thomas
A1  - Wegner, Christian
A1  - Zender, Raphael
A1  - Lucke, Ulrike
A1  - Diethelm, Ira
A1  - Syrbe, Jörn
A1  - Lai, Kwok-Wing
A1  - Davis, Niki
A1  - Eickelmann, Birgit
A1  - Erstad, Ola
A1  - Fisser, Petra
A1  - Gibson, David
A1  - Khaddage, Ferial
A1  - Knezek, Gerald
A1  - Micheuz, Peter
A1  - Kloos, Carlos Delgado
ED  - Brinda, Torsten
ED  - Reynolds, Nicholas
ED  - Romeike, Ralf
ED  - Schwill, Andreas
T1  - KEYCIT 2014
BT  - key competencies in informatics and ICT
N2  - In our rapidly changing world it is increasingly important not only to be an expert in a chosen field of study but also to be able to respond to developments, master new approaches to solving problems, and fulfil changing requirements in the modern world and in the job market. In response to these needs key competencies in understanding, developing and using new digital technologies are being brought into focus in school and university programmes. The IFIP TC3 conference "KEYCIT – Key Competences in Informatics and ICT (KEYCIT 2014)" was held at the University of Potsdam in Germany from July 1st to 4th, 2014 and addressed the combination of key competencies, Informatics and ICT in detail. The conference was organized into strands focusing on secondary education, university education and teacher education (organized by IFIP WGs 3.1 and 3.3) and provided a forum to present and to discuss research, case studies, positions, and national perspectives in this field.
T3  - Commentarii informaticae didacticae (CID) - 7 
KW  - Schlüsselkompetenzen
KW  - Informatik
KW  - Bildung
KW  - ICT
KW  - Informatikdidaktik
KW  - Key Competencies
KW  - Informatics
KW  - education
KW  - ICT
KW  - Computer Science Education
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-70325
SN  - 978-3-86956-292-6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Opel, Simone
A1  - Kramer, Matthias
A1  - Trommen, Michael
A1  - Pottbäcker, Florian
A1  - Ilaghef, Youssef
T1  - BugHunt
BT  - A Motivating Approach to Self-Directed Problem-solving in Operating Systems
JF  - KEYCIT 2014 - Key Competencies in Informatics and ICT
N2  - Competencies related to operating systems and computer
security are usually taught systematically. In this paper we present
a different approach, in which students have to remove virus-like
behaviour on their respective computers, which has been induced by
software developed for this purpose. They have to develop appropriate
problem-solving strategies and thereby explore essential elements of
the operating system. The approach was implemented exemplarily in
two computer science courses at a regional general upper secondary
school and showed great motivation and interest in the participating
students.
KW  - Educational software
KW  - operating system
KW  - student activation
KW  - problem-solving
KW  - interactive course
KW  - interactive workshop
KW  - edutainment
KW  - secondary computer science education
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-82693
SN  - 1868-0844
SN  - 2191-1940
IS  - 7
SP  - 217
EP  - 233
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  -