TY  - JOUR
A1  - Koenig, Julian
A1  - Abler, Birgit
A1  - Agartz, Ingrid
A1  - akerstedt, Torbjorn
A1  - Andreassen, Ole A.
A1  - Anthony, Mia
A1  - Baer, Karl-Juergen
A1  - Bertsch, Katja
A1  - Brown, Rebecca C.
A1  - Brunner, Romuald
A1  - Carnevali, Luca
A1  - Critchley, Hugo D.
A1  - Cullen, Kathryn R.
A1  - de Geus, Eco J. C.
A1  - de la Cruz, Feliberto
A1  - Dziobek, Isabel
A1  - Ferger, Marc D.
A1  - Fischer, Hakan
A1  - Flor, Herta
A1  - Gaebler, Michael
A1  - Gianaros, Peter J.
A1  - Giummarra, Melita J.
A1  - Greening, Steven G.
A1  - Guendelman, Simon
A1  - Heathers, James A. J.
A1  - Herpertz, Sabine C.
A1  - Hu, Mandy X.
A1  - Jentschke, Sebastian
A1  - Kaess, Michael
A1  - Kaufmann, Tobias
A1  - Klimes-Dougan, Bonnie
A1  - Koelsch, Stefan
A1  - Krauch, Marlene
A1  - Kumral, Deniz
A1  - Lamers, Femke
A1  - Lee, Tae-Ho
A1  - Lekander, Mats
A1  - Lin, Feng
A1  - Lotze, Martin
A1  - Makovac, Elena
A1  - Mancini, Matteo
A1  - Mancke, Falk
A1  - Mansson, Kristoffer N. T.
A1  - Manuck, Stephen B.
A1  - Mather, Mara
A1  - Meeten, Frances
A1  - Min, Jungwon
A1  - Mueller, Bryon
A1  - Muench, Vera
A1  - Nees, Frauke
A1  - Nga, Lin
A1  - Nilsonne, Gustav
A1  - Ordonez Acuna, Daniela
A1  - Osnes, Berge
A1  - Ottaviani, Cristina
A1  - Penninx, Brenda W. J. H.
A1  - Ponzio, Allison
A1  - Poudel, Govinda R.
A1  - Reinelt, Janis
A1  - Ren, Ping
A1  - Sakaki, Michiko
A1  - Schumann, Andy
A1  - Sorensen, Lin
A1  - Specht, Karsten
A1  - Straub, Joana
A1  - Tamm, Sandra
A1  - Thai, Michelle
A1  - Thayer, Julian F.
A1  - Ubani, Benjamin
A1  - van Der Mee, Denise J.
A1  - van Velzen, Laura S.
A1  - Ventura-Bort, Carlos
A1  - Villringer, Arno
A1  - Watson, David R.
A1  - Wei, Luqing
A1  - Wendt, Julia
A1  - Schreiner, Melinda Westlund
A1  - Westlye, Lars T.
A1  - Weymar, Mathias
A1  - Winkelmann, Tobias
A1  - Wu, Guo-Rong
A1  - Yoo, Hyun Joo
A1  - Quintana, Daniel S.
T1  - Cortical thickness and resting-state cardiac function across the lifespan
BT  - a cross-sectional pooled mega-analysis
JF  - Psychophysiology : journal of the Society for Psychophysiological Research
N2  - Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
KW  - aging
KW  - autonomic nervous system
KW  - cortical thickness
KW  - heart rate
KW  - heart
KW  - rate variability
KW  - sex
Y1  - 2020
U6  - https://doi.org/10.1111/psyp.13688
SN  - 0048-5772
SN  - 1469-8986
VL  - 58
IS  - 7
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Moerschbacher, Bruno
A1  - Jaworska, Małgorzata
A1  - Peter, Martin G.
T1  - Obituary of George A.F. Roberts (1939-2018)
T2  - Reactive & functional polymers
Y1  - 2020
U6  - https://doi.org/10.1016/j.reactfunctpolym.2020.104711
SN  - 1381-5148
SN  - 1873-166X
VL  - 156
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - JOUR
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
JF  - Kidney international : official journal of the International Society of Nephrology
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - https://doi.org/10.1016/j.kint.2020.09.030
SN  - 0085-2538
SN  - 1523-1755
VL  - 99
IS  - 4
SP  - 926
EP  - 939
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Middeldorp, Christel M.
A1  - Mahajan, Anubha
A1  - Horikoshi, Momoko
A1  - Robertson, Neil R.
A1  - Beaumont, Robin N.
A1  - Bradfield, Jonathan P.
A1  - Bustamante, Mariona
A1  - Cousminer, Diana L.
A1  - Day, Felix R.
A1  - De Silva, N. Maneka
A1  - Guxens, Monica
A1  - Mook-Kanamori, Dennis O.
A1  - St Pourcain, Beate
A1  - Warrington, Nicole M.
A1  - Adair, Linda S.
A1  - Ahlqvist, Emma
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Ang, Wei
A1  - Atalay, Mustafa
A1  - Auvinen, Juha
A1  - Bartels, Meike
A1  - Beckmann, Jacques S.
A1  - Bilbao, Jose Ramon
A1  - Bond, Tom
A1  - Borja, Judith B.
A1  - Cavadino, Alana
A1  - Charoen, Pimphen
A1  - Chen, Zhanghua
A1  - Coin, Lachlan
A1  - Cooper, Cyrus
A1  - Curtin, John A.
A1  - Custovic, Adnan
A1  - Das, Shikta
A1  - Davies, Gareth E.
A1  - Dedoussis, George V.
A1  - Duijts, Liesbeth
A1  - Eastwood, Peter R.
A1  - Eliasen, Anders U.
A1  - Elliott, Paul
A1  - Eriksson, Johan G.
A1  - Estivill, Xavier
A1  - Fadista, Joao
A1  - Fedko, Iryna O.
A1  - Frayling, Timothy M.
A1  - Gaillard, Romy
A1  - Gauderman, W. James
A1  - Geller, Frank
A1  - Gilliland, Frank
A1  - Gilsanz, Vincente
A1  - Granell, Raquel
A1  - Grarup, Niels
A1  - Groop, Leif
A1  - Hadley, Dexter
A1  - Hakonarson, Hakon
A1  - Hansen, Torben
A1  - Hartman, Catharina A.
A1  - Hattersley, Andrew T.
A1  - Hayes, M. Geoffrey
A1  - Hebebrand, Johannes
A1  - Heinrich, Joachim
A1  - Helgeland, Oyvind
A1  - Henders, Anjali K.
A1  - Henderson, John
A1  - Henriksen, Tine B.
A1  - Hirschhorn, Joel N.
A1  - Hivert, Marie-France
A1  - Hocher, Berthold
A1  - Holloway, John W.
A1  - Holt, Patrick
A1  - Hottenga, Jouke-Jan
A1  - Hypponen, Elina
A1  - Iniguez, Carmen
A1  - Johansson, Stefan
A1  - Jugessur, Astanand
A1  - Kahonen, Mika
A1  - Kalkwarf, Heidi J.
A1  - Kaprio, Jaakko
A1  - Karhunen, Ville
A1  - Kemp, John P.
A1  - Kerkhof, Marjan
A1  - Koppelman, Gerard H.
A1  - Korner, Antje
A1  - Kotecha, Sailesh
A1  - Kreiner-Moller, Eskil
A1  - Kulohoma, Benard
A1  - Kumar, Ashish
A1  - Kutalik, Zoltan
A1  - Lahti, Jari
A1  - Lappe, Joan M.
A1  - Larsson, Henrik
A1  - Lehtimaki, Terho
A1  - Lewin, Alexandra M.
A1  - Li, Jin
A1  - Lichtenstein, Paul
A1  - Lindgren, Cecilia M.
A1  - Lindi, Virpi
A1  - Linneberg, Allan
A1  - Liu, Xueping
A1  - Liu, Jun
A1  - Lowe, William L.
A1  - Lundstrom, Sebastian
A1  - Lyytikainen, Leo-Pekka
A1  - Ma, Ronald C. W.
A1  - Mace, Aurelien
A1  - Magi, Reedik
A1  - Magnus, Per
A1  - Mamun, Abdullah A.
A1  - Mannikko, Minna
A1  - Martin, Nicholas G.
A1  - Mbarek, Hamdi
A1  - McCarthy, Nina S.
A1  - Medland, Sarah E.
A1  - Melbye, Mads
A1  - Melen, Erik
A1  - Mohlke, Karen L.
A1  - Monnereau, Claire
A1  - Morgen, Camilla S.
A1  - Morris, Andrew P.
A1  - Murray, Jeffrey C.
A1  - Myhre, Ronny
A1  - Najman, Jackob M.
A1  - Nivard, Michel G.
A1  - Nohr, Ellen A.
A1  - Nolte, Ilja M.
A1  - Ntalla, Ioanna
A1  - Oberfield, Sharon E.
A1  - Oken, Emily
A1  - Oldehinkel, Albertine J.
A1  - Pahkala, Katja
A1  - Palviainen, Teemu
A1  - Panoutsopoulou, Kalliope
A1  - Pedersen, Oluf
A1  - Pennell, Craig E.
A1  - Pershagen, Goran
A1  - Pitkanen, Niina
A1  - Plomin, Robert
A1  - Power, Christine
A1  - Prasad, Rashmi B.
A1  - Prokopenko, Inga
A1  - Pulkkinen, Lea
A1  - Raikkonen, Katri
A1  - Raitakari, Olli T.
A1  - Reynolds, Rebecca M.
A1  - Richmond, Rebecca C.
A1  - Rivadeneira, Fernando
A1  - Rodriguez, Alina
A1  - Rose, Richard J.
A1  - Salem, Rany
A1  - Santa-Marina, Loreto
A1  - Saw, Seang-Mei
A1  - Schnurr, Theresia M.
A1  - Scott, James G.
A1  - Selzam, Saskia
A1  - Shepherd, John A.
A1  - Simpson, Angela
A1  - Skotte, Line
A1  - Sleiman, Patrick M. A.
A1  - Snieder, Harold
A1  - Sorensen, Thorkild I. A.
A1  - Standl, Marie
A1  - Steegers, Eric A. P.
A1  - Strachan, David P.
A1  - Straker, Leon
A1  - Strandberg, Timo
A1  - Taylor, Michelle
A1  - Teo, Yik-Ying
A1  - Thiering, Elisabeth
A1  - Torrent, Maties
A1  - Tyrrell, Jessica
A1  - Uitterlinden, Andre G.
A1  - van Beijsterveldt, Toos
A1  - van der Most, Peter J.
A1  - van Duijn, Cornelia M.
A1  - Viikari, Jorma
A1  - Vilor-Tejedor, Natalia
A1  - Vogelezang, Suzanne
A1  - Vonk, Judith M.
A1  - Vrijkotte, Tanja G. M.
A1  - Vuoksimaa, Eero
A1  - Wang, Carol A.
A1  - Watkins, William J.
A1  - Wichmann, H-Erich
A1  - Willemsen, Gonneke
A1  - Williams, Gail M.
A1  - Wilson, James F.
A1  - Wray, Naomi R.
A1  - Xu, Shujing
A1  - Xu, Cheng-Jian
A1  - Yaghootkar, Hanieh
A1  - Yi, Lu
A1  - Zafarmand, Mohammad Hadi
A1  - Zeggini, Eleftheria
A1  - Zemel, Babette S.
A1  - Hinney, Anke
A1  - Lakka, Timo A.
A1  - Whitehouse, Andrew J. O.
A1  - Sunyer, Jordi
A1  - Widen, Elisabeth E.
A1  - Feenstra, Bjarke
A1  - Sebert, Sylvain
A1  - Jacobsson, Bo
A1  - Njolstad, Pal R.
A1  - Stoltenberg, Camilla
A1  - Smith, George Davey
A1  - Lawlor, Debbie A.
A1  - Paternoster, Lavinia
A1  - Timpson, Nicholas J.
A1  - Ong, Ken K.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Jaddoe, Vincent W. V.
A1  - Tiemeier, Henning
A1  - Jarvelin, Marjo-Riitta
A1  - Evans, David M.
A1  - Perry, John R. B.
A1  - Grant, Struan F. A.
A1  - Boomsma, Dorret I.
A1  - Freathy, Rachel M.
A1  - McCarthy, Mark I.
A1  - Felix, Janine F.
T1  - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
BT  - design, results and future prospects
JF  - European journal of epidemiology
N2  - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
KW  - Genetics
KW  - Consortium
KW  - Childhood traits and disorders
KW  - Longitudinal
Y1  - 2019
U6  - https://doi.org/10.1007/s10654-019-00502-9
SN  - 0393-2990
SN  - 1573-7284
VL  - 34
IS  - 3
SP  - 279
EP  - 300
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Dengler, Jürgen
A1  - Wagner, Viktoria
A1  - Dembicz, Iwona
A1  - Garcia-Mijangos, Itziar
A1  - Naqinezhad, Alireza
A1  - Boch, Steffen
A1  - Chiarucci, Alessandro
A1  - Conradi, Timo
A1  - Filibeck, Goffredo
A1  - Guarino, Riccardo
A1  - Janisova, Monika
A1  - Steinbauer, Manuel J.
A1  - Acic, Svetlana
A1  - Acosta, Alicia T. R.
A1  - Akasaka, Munemitsu
A1  - Allers, Marc-Andre
A1  - Apostolova, Iva
A1  - Axmanova, Irena
A1  - Bakan, Branko
A1  - Baranova, Alina
A1  - Bardy-Durchhalter, Manfred
A1  - Bartha, Sandor
A1  - Baumann, Esther
A1  - Becker, Thomas
A1  - Becker, Ute
A1  - Belonovskaya, Elena
A1  - Bengtsson, Karin
A1  - Benito Alonso, Jose Luis
A1  - Berastegi, Asun
A1  - Bergamini, Ariel
A1  - Bonini, Ilaria
A1  - Bruun, Hans Henrik
A1  - Budzhak, Vasyl
A1  - Bueno, Alvaro
A1  - Antonio Campos, Juan
A1  - Cancellieri, Laura
A1  - Carboni, Marta
A1  - Chocarro, Cristina
A1  - Conti, Luisa
A1  - Czarniecka-Wiera, Marta
A1  - De Frenne, Pieter
A1  - Deak, Balazs
A1  - Didukh, Yakiv P.
A1  - Diekmann, Martin
A1  - Dolnik, Christian
A1  - Dupre, Cecilia
A1  - Ecker, Klaus
A1  - Ermakov, Nikolai
A1  - Erschbamer, Brigitta
A1  - Escudero, Adrian
A1  - Etayo, Javier
A1  - Fajmonova, Zuzana
A1  - Felde, Vivian A.
A1  - Fernandez Calzado, Maria Rosa
A1  - Finckh, Manfred
A1  - Fotiadis, Georgios
A1  - Fracchiolla, Mariano
A1  - Ganeva, Anna
A1  - Garcia-Magro, Daniel
A1  - Gavilan, Rosario G.
A1  - Germany, Markus
A1  - Giladi, Itamar
A1  - Gillet, Francois
A1  - Giusso del Galdo, Gian Pietro
A1  - Gonzalez, Jose M.
A1  - Grytnes, John-Arvid
A1  - Hajek, Michal
A1  - Hajkova, Petra
A1  - Helm, Aveliina
A1  - Herrera, Mercedes
A1  - Hettenbergerova, Eva
A1  - Hobohm, Carsten
A1  - Huellbusch, Elisabeth M.
A1  - Ingerpuu, Nele
A1  - Jandt, Ute
A1  - Jeltsch, Florian
A1  - Jensen, Kai
A1  - Jentsch, Anke
A1  - Jeschke, Michael
A1  - Jimenez-Alfaro, Borja
A1  - Kacki, Zygmunt
A1  - Kakinuma, Kaoru
A1  - Kapfer, Jutta
A1  - Kavgaci, Ali
A1  - Kelemen, Andras
A1  - Kiehl, Kathrin
A1  - Koyama, Asuka
A1  - Koyanagi, Tomoyo F.
A1  - Kozub, Lukasz
A1  - Kuzemko, Anna
A1  - Kyrkjeeide, Magni Olsen
A1  - Landi, Sara
A1  - Langer, Nancy
A1  - Lastrucci, Lorenzo
A1  - Lazzaro, Lorenzo
A1  - Lelli, Chiara
A1  - Leps, Jan
A1  - Loebel, Swantje
A1  - Luzuriaga, Arantzazu L.
A1  - Maccherini, Simona
A1  - Magnes, Martin
A1  - Malicki, Marek
A1  - Marceno, Corrado
A1  - Mardari, Constantin
A1  - Mauchamp, Leslie
A1  - May, Felix
A1  - Michelsen, Ottar
A1  - Mesa, Joaquin Molero
A1  - Molnar, Zsolt
A1  - Moysiyenko, Ivan Y.
A1  - Nakaga, Yuko K.
A1  - Natcheva, Rayna
A1  - Noroozi, Jalil
A1  - Pakeman, Robin J.
A1  - Palpurina, Salza
A1  - Partel, Meelis
A1  - Paetsch, Ricarda
A1  - Pauli, Harald
A1  - Pedashenko, Hristo
A1  - Peet, Robert K.
A1  - Pielech, Remigiusz
A1  - Pipenbaher, Natasa
A1  - Pirini, Chrisoula
A1  - Pleskova, Zuzana
A1  - Polyakova, Mariya A.
A1  - Prentice, Honor C.
A1  - Reinecke, Jennifer
A1  - Reitalu, Triin
A1  - Pilar Rodriguez-Rojo, Maria
A1  - Rolecek, Jan
A1  - Ronkin, Vladimir
A1  - Rosati, Leonardo
A1  - Rosen, Ejvind
A1  - Ruprecht, Eszter
A1  - Rusina, Solvita
A1  - Sabovljevic, Marko
A1  - Maria Sanchez, Ana
A1  - Savchenko, Galina
A1  - Schuhmacher, Oliver
A1  - Skornik, Sonja
A1  - Sperandii, Marta Gaia
A1  - Staniaszek-Kik, Monika
A1  - Stevanovic-Dajic, Zora
A1  - Stock, Marin
A1  - Suchrow, Sigrid
A1  - Sutcliffe, Laura M. E.
A1  - Swacha, Grzegorz
A1  - Sykes, Martin
A1  - Szabo, Anna
A1  - Talebi, Amir
A1  - Tanase, Catalin
A1  - Terzi, Massimo
A1  - Tolgyesi, Csaba
A1  - Torca, Marta
A1  - Torok, Peter
A1  - Tothmeresz, Bela
A1  - Tsarevskaya, Nadezda
A1  - Tsiripidis, Ioannis
A1  - Tzonev, Rossen
A1  - Ushimaru, Atushi
A1  - Valko, Orsolya
A1  - van der Maarel, Eddy
A1  - Vanneste, Thomas
A1  - Vashenyak, Iuliia
A1  - Vassilev, Kiril
A1  - Viciani, Daniele
A1  - Villar, Luis
A1  - Virtanen, Risto
A1  - Kosic, Ivana Vitasovic
A1  - Wang, Yun
A1  - Weiser, Frank
A1  - Went, Julia
A1  - Wesche, Karsten
A1  - White, Hannah
A1  - Winkler, Manuela
A1  - Zaniewski, Piotr T.
A1  - Zhang, Hui
A1  - Ziv, Yaron
A1  - Znamenskiy, Sergey
A1  - Biurrun, Idoia
T1  - GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands
JF  - Phytocoenologia
N2  - GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
KW  - biodiversity
KW  - European Vegetation Archive (EVA)
KW  - Eurasian Dry Grassland Group (EDGG)
KW  - grassland vegetation
KW  - GrassPlot
KW  - macroecology
KW  - multi-taxon
KW  - nested plot
KW  - scale-dependence
KW  - species-area relationship (SAR)
KW  - sPlot
KW  - vegetation-plot database
Y1  - 2018
U6  - https://doi.org/10.1127/phyto/2018/0267
SN  - 0340-269X
VL  - 48
IS  - 3
SP  - 331
EP  - 347
PB  - Cramer
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Mantzouki, Evanthia
A1  - Lurling, Miquel
A1  - Fastner, Jutta
A1  - Domis, Lisette Nicole de Senerpont
A1  - Wilk-Wozniak, Elzbieta
A1  - Koreiviene, Judita
A1  - Seelen, Laura
A1  - Teurlincx, Sven
A1  - Verstijnen, Yvon
A1  - Krzton, Wojciech
A1  - Walusiak, Edward
A1  - Karosiene, Jurate
A1  - Kasperoviciene, Jurate
A1  - Savadova, Ksenija
A1  - Vitonyte, Irma
A1  - Cillero-Castro, Carmen
A1  - Budzynska, Agnieszka
A1  - Goldyn, Ryszard
A1  - Kozak, Anna
A1  - Rosinska, Joanna
A1  - Szelag-Wasielewska, Elzbieta
A1  - Domek, Piotr
A1  - Jakubowska-Krepska, Natalia
A1  - Kwasizur, Kinga
A1  - Messyasz, Beata
A1  - Pelechata, Aleksandra
A1  - Pelechaty, Mariusz
A1  - Kokocinski, Mikolaj
A1  - Garcia-Murcia, Ana
A1  - Real, Monserrat
A1  - Romans, Elvira
A1  - Noguero-Ribes, Jordi
A1  - Parreno Duque, David
A1  - Fernandez-Moran, Elisabeth
A1  - Karakaya, Nusret
A1  - Haggqvist, Kerstin
A1  - Demir, Nilsun
A1  - Beklioglu, Meryem
A1  - Filiz, Nur
A1  - Levi, Eti E.
A1  - Iskin, Ugur
A1  - Bezirci, Gizem
A1  - Tavsanoglu, Ulku Nihan
A1  - Ozhan, Koray
A1  - Gkelis, Spyros
A1  - Panou, Manthos
A1  - Fakioglu, Ozden
A1  - Avagianos, Christos
A1  - Kaloudis, Triantafyllos
A1  - Celik, Kemal
A1  - Yilmaz, Mete
A1  - Marce, Rafael
A1  - Catalan, Nuria
A1  - Bravo, Andrea G.
A1  - Buck, Moritz
A1  - Colom-Montero, William
A1  - Mustonen, Kristiina
A1  - Pierson, Don
A1  - Yang, Yang
A1  - Raposeiro, Pedro M.
A1  - Goncalves, Vitor
A1  - Antoniou, Maria G.
A1  - Tsiarta, Nikoletta
A1  - McCarthy, Valerie
A1  - Perello, Victor C.
A1  - Feldmann, Tonu
A1  - Laas, Alo
A1  - Panksep, Kristel
A1  - Tuvikene, Lea
A1  - Gagala, Ilona
A1  - Mankiewicz-Boczek, Joana
A1  - Yagci, Meral Apaydin
A1  - Cinar, Sakir
A1  - Capkin, Kadir
A1  - Yagci, Abdulkadir
A1  - Cesur, Mehmet
A1  - Bilgin, Fuat
A1  - Bulut, Cafer
A1  - Uysal, Rahmi
A1  - Obertegger, Ulrike
A1  - Boscaini, Adriano
A1  - Flaim, Giovanna
A1  - Salmaso, Nico
A1  - Cerasino, Leonardo
A1  - Richardson, Jessica
A1  - Visser, Petra M.
A1  - Verspagen, Jolanda M. H.
A1  - Karan, Tunay
A1  - Soylu, Elif Neyran
A1  - Maraslioglu, Faruk
A1  - Napiorkowska-Krzebietke, Agnieszka
A1  - Ochocka, Agnieszka
A1  - Pasztaleniec, Agnieszka
A1  - Antao-Geraldes, Ana M.
A1  - Vasconcelos, Vitor
A1  - Morais, Joao
A1  - Vale, Micaela
A1  - Koker, Latife
A1  - Akcaalan, Reyhan
A1  - Albay, Meric
A1  - Maronic, Dubravka Spoljaric
A1  - Stevic, Filip
A1  - Pfeiffer, Tanja Zuna
A1  - Fonvielle, Jeremy Andre
A1  - Straile, Dietmar
A1  - Rothhaupt, Karl-Otto
A1  - Hansson, Lars-Anders
A1  - Urrutia-Cordero, Pablo
A1  - Blaha, Ludek
A1  - Geris, Rodan
A1  - Frankova, Marketa
A1  - Kocer, Mehmet Ali Turan
A1  - Alp, Mehmet Tahir
A1  - Remec-Rekar, Spela
A1  - Elersek, Tina
A1  - Triantis, Theodoros
A1  - Zervou, Sevasti-Kiriaki
A1  - Hiskia, Anastasia
A1  - Haande, Sigrid
A1  - Skjelbred, Birger
A1  - Madrecka, Beata
A1  - Nemova, Hana
A1  - Drastichova, Iveta
A1  - Chomova, Lucia
A1  - Edwards, Christine
A1  - Sevindik, Tugba Ongun
A1  - Tunca, Hatice
A1  - OEnem, Burcin
A1  - Aleksovski, Boris
A1  - Krstic, Svetislav
A1  - Vucelic, Itana Bokan
A1  - Nawrocka, Lidia
A1  - Salmi, Pauliina
A1  - Machado-Vieira, Danielle
A1  - de Oliveira, Alinne Gurjao
A1  - Delgado-Martin, Jordi
A1  - Garcia, David
A1  - Cereijo, Jose Luis
A1  - Goma, Joan
A1  - Trapote, Mari Carmen
A1  - Vegas-Vilarrubia, Teresa
A1  - Obrador, Biel
A1  - Grabowska, Magdalena
A1  - Karpowicz, Maciej
A1  - Chmura, Damian
A1  - Ubeda, Barbara
A1  - Angel Galvez, Jose
A1  - Ozen, Arda
A1  - Christoffersen, Kirsten Seestern
A1  - Warming, Trine Perlt
A1  - Kobos, Justyna
A1  - Mazur-Marzec, Hanna
A1  - Perez-Martinez, Carmen
A1  - Ramos-Rodriguez, Eloisa
A1  - Arvola, Lauri
A1  - Alcaraz-Parraga, Pablo
A1  - Toporowska, Magdalena
A1  - Pawlik-Skowronska, Barbara
A1  - Niedzwiecki, Michal
A1  - Peczula, Wojciech
A1  - Leira, Manel
A1  - Hernandez, Armand
A1  - Moreno-Ostos, Enrique
A1  - Maria Blanco, Jose
A1  - Rodriguez, Valeriano
A1  - Juan Montes-Perez, Jorge
A1  - Palomino, Roberto L.
A1  - Rodriguez-Perez, Estela
A1  - Carballeira, Rafael
A1  - Camacho, Antonio
A1  - Picazo, Antonio
A1  - Rochera, Carlos
A1  - Santamans, Anna C.
A1  - Ferriol, Carmen
A1  - Romo, Susana
A1  - Miguel Soria, Juan
A1  - Dunalska, Julita
A1  - Sienska, Justyna
A1  - Szymanski, Daniel
A1  - Kruk, Marek
A1  - Kostrzewska-Szlakowska, Iwona
A1  - Jasser, Iwona
A1  - Zutinic, Petar
A1  - Udovic, Marija Gligora
A1  - Plenkovic-Moraj, Andelka
A1  - Frak, Magdalena
A1  - Bankowska-Sobczak, Agnieszka
A1  - Wasilewicz, Michal
A1  - Ozkan, Korhan
A1  - Maliaka, Valentini
A1  - Kangro, Kersti
A1  - Grossart, Hans-Peter
A1  - Paerl, Hans W.
A1  - Carey, Cayelan C.
A1  - Ibelings, Bas W.
T1  - Temperature effects explain continental scale distribution of cyanobacterial toxins
JF  - Toxins
N2  - Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.
KW  - microcystin
KW  - anatoxin
KW  - cylindrospermopsin
KW  - temperature
KW  - direct effects
KW  - indirect effects
KW  - spatial distribution
KW  - European Multi Lake Survey
Y1  - 2018
U6  - https://doi.org/10.3390/toxins10040156
SN  - 2072-6651
VL  - 10
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Mantzouki, Evanthia
A1  - Campbell, James
A1  - van Loon, Emiel
A1  - Visser, Petra
A1  - Konstantinou, Iosif
A1  - Antoniou, Maria
A1  - Giuliani, Gregory
A1  - Machado-Vieira, Danielle
A1  - de Oliveira, Alinne Gurjao
A1  - Maronic, Dubravka Spoljaric
A1  - Stevic, Filip
A1  - Pfeiffer, Tanja Zuna
A1  - Vucelic, Itana Bokan
A1  - Zutinic, Petar
A1  - Udovic, Marija Gligora
A1  - Plenkovic-Moraj, Andelka
A1  - Tsiarta, Nikoletta
A1  - Blaha, Ludek
A1  - Geris, Rodan
A1  - Frankova, Marketa
A1  - Christoffersen, Kirsten Seestern
A1  - Warming, Trine Perlt
A1  - Feldmann, Tonu
A1  - Laas, Alo
A1  - Panksep, Kristel
A1  - Tuvikene, Lea
A1  - Kangro, Kersti
A1  - Haggqvist, Kerstin
A1  - Salmi, Pauliina
A1  - Arvola, Lauri
A1  - Fastner, Jutta
A1  - Straile, Dietmar
A1  - Rothhaupt, Karl-Otto
A1  - Fonvielle, Jeremy Andre
A1  - Grossart, Hans-Peter
A1  - Avagianos, Christos
A1  - Kaloudis, Triantafyllos
A1  - Triantis, Theodoros
A1  - Zervou, Sevasti-Kiriaki
A1  - Hiskia, Anastasia
A1  - Gkelis, Spyros
A1  - Panou, Manthos
A1  - McCarthy, Valerie
A1  - Perello, Victor C.
A1  - Obertegger, Ulrike
A1  - Boscaini, Adriano
A1  - Flaim, Giovanna
A1  - Salmaso, Nico
A1  - Cerasino, Leonardo
A1  - Koreiviene, Judita
A1  - Karosiene, Jurate
A1  - Kasperoviciene, Jurate
A1  - Savadova, Ksenija
A1  - Vitonyte, Irma
A1  - Haande, Sigrid
A1  - Skjelbred, Birger
A1  - Grabowska, Magdalena
A1  - Karpowicz, Maciej
A1  - Chmura, Damian
A1  - Nawrocka, Lidia
A1  - Kobos, Justyna
A1  - Mazur-Marzec, Hanna
A1  - Alcaraz-Parraga, Pablo
A1  - Wilk-Wozniak, Elzbieta
A1  - Krzton, Wojciech
A1  - Walusiak, Edward
A1  - Gagala, Ilona
A1  - Mankiewicz-Boczek, Joana
A1  - Toporowska, Magdalena
A1  - Pawlik-Skowronska, Barbara
A1  - Niedzwiecki, Michal
A1  - Peczula, Wojciech
A1  - Napiorkowska-Krzebietke, Agnieszka
A1  - Dunalska, Julita
A1  - Sienska, Justyna
A1  - Szymanski, Daniel
A1  - Kruk, Marek
A1  - Budzynska, Agnieszka
A1  - Goldyn, Ryszard
A1  - Kozak, Anna
A1  - Rosinska, Joanna
A1  - Szelag-Wasielewska, Elzbieta
A1  - Domek, Piotr
A1  - Jakubowska-Krepska, Natalia
A1  - Kwasizur, Kinga
A1  - Messyasz, Beata
A1  - Pelechata, Aleksandra
A1  - Pelechaty, Mariusz
A1  - Kokocinski, Mikolaj
A1  - Madrecka, Beata
A1  - Kostrzewska-Szlakowska, Iwona
A1  - Frak, Magdalena
A1  - Bankowska-Sobczak, Agnieszka
A1  - Wasilewicz, Michal
A1  - Ochocka, Agnieszka
A1  - Pasztaleniec, Agnieszka
A1  - Jasser, Iwona
A1  - Antao-Geraldes, Ana M.
A1  - Leira, Manel
A1  - Hernandez, Armand
A1  - Vasconcelos, Vitor
A1  - Morais, Joao
A1  - Vale, Micaela
A1  - Raposeiro, Pedro M.
A1  - Goncalves, Vitor
A1  - Aleksovski, Boris
A1  - Krstic, Svetislav
A1  - Nemova, Hana
A1  - Drastichova, Iveta
A1  - Chomova, Lucia
A1  - Remec-Rekar, Spela
A1  - Elersek, Tina
A1  - Delgado-Martin, Jordi
A1  - Garcia, David
A1  - Luis Cereijo, Jose
A1  - Goma, Joan
A1  - Carmen Trapote, Mari
A1  - Vegas-Vilarrubia, Teresa
A1  - Obrador, Biel
A1  - Garcia-Murcia, Ana
A1  - Real, Monserrat
A1  - Romans, Elvira
A1  - Noguero-Ribes, Jordi
A1  - Parreno Duque, David
A1  - Fernandez-Moran, Elisabeth
A1  - Ubeda, Barbara
A1  - Angel Galvez, Jose
A1  - Marce, Rafael
A1  - Catalan, Nuria
A1  - Perez-Martinez, Carmen
A1  - Ramos-Rodriguez, Eloisa
A1  - Cillero-Castro, Carmen
A1  - Moreno-Ostos, Enrique
A1  - Maria Blanco, Jose
A1  - Rodriguez, Valeriano
A1  - Juan Montes-Perez, Jorge
A1  - Palomino, Roberto L.
A1  - Rodriguez-Perez, Estela
A1  - Carballeira, Rafael
A1  - Camacho, Antonio
A1  - Picazo, Antonio
A1  - Rochera, Carlos
A1  - Santamans, Anna C.
A1  - Ferriol, Carmen
A1  - Romo, Susana
A1  - Soria, Juan Miguel
A1  - Hansson, Lars-Anders
A1  - Urrutia-Cordero, Pablo
A1  - Ozen, Arda
A1  - Bravo, Andrea G.
A1  - Buck, Moritz
A1  - Colom-Montero, William
A1  - Mustonen, Kristiina
A1  - Pierson, Don
A1  - Yang, Yang
A1  - Verspagen, Jolanda M. H.
A1  - Domis, Lisette N. de Senerpont
A1  - Seelen, Laura
A1  - Teurlincx, Sven
A1  - Verstijnen, Yvon
A1  - Lurling, Miquel
A1  - Maliaka, Valentini
A1  - Faassen, Elisabeth J.
A1  - Latour, Delphine
A1  - Carey, Cayelan C.
A1  - Paerl, Hans W.
A1  - Torokne, Andrea
A1  - Karan, Tunay
A1  - Demir, Nilsun
A1  - Beklioglu, Meryem
A1  - Filiz, Nur
A1  - Levi, Eti E.
A1  - Iskin, Ugur
A1  - Bezirci, Gizem
A1  - Tavsanoglu, Ulku Nihan
A1  - Celik, Kemal
A1  - Ozhan, Koray
A1  - Karakaya, Nusret
A1  - Kocer, Mehmet Ali Turan
A1  - Yilmaz, Mete
A1  - Maraslioglu, Faruk
A1  - Fakioglu, Ozden
A1  - Soylu, Elif Neyran
A1  - Yagci, Meral Apaydin
A1  - Cinar, Sakir
A1  - Capkin, Kadir
A1  - Yagci, Abdulkadir
A1  - Cesur, Mehmet
A1  - Bilgin, Fuat
A1  - Bulut, Cafer
A1  - Uysal, Rahmi
A1  - Koker, Latife
A1  - Akcaalan, Reyhan
A1  - Albay, Meric
A1  - Alp, Mehmet Tahir
A1  - Ozkan, Korhan
A1  - Sevindik, Tugba Ongun
A1  - Tunca, Hatice
A1  - Onem, Burcin
A1  - Richardson, Jessica
A1  - Edwards, Christine
A1  - Bergkemper, Victoria
A1  - Beirne, Eilish
A1  - Cromie, Hannah
A1  - Ibelings, Bastiaan W.
T1  - Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
JF  - Scientific Data
N2  - Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.
KW  - Climate-change ecology
KW  - Limnology
KW  - Water resources
Y1  - 2018
U6  - https://doi.org/10.1038/sdata.2018.226
SN  - 2052-4463
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Mantzouki, Evanthia
A1  - Lürling, Miquel
A1  - Fastner, Jutta
A1  - Domis, Lisette Nicole de Senerpont
A1  - Wilk-Woźniak, Elżbieta
A1  - Koreiviene, Judita
A1  - Seelen, Laura
A1  - Teurlincx, Sven
A1  - Verstijnen, Yvon
A1  - Krztoń, Wojciech
A1  - Walusiak, Edward
A1  - Karosienė, Jūratė
A1  - Kasperovičienė, Jūratė
A1  - Savadova, Ksenija
A1  - Vitonytė, Irma
A1  - Cillero-Castro, Carmen
A1  - Budzyńska, Agnieszka
A1  - Goldyn, Ryszard
A1  - Kozak, Anna
A1  - Rosińska, Joanna
A1  - Szeląg-Wasielewska, Elżbieta
A1  - Domek, Piotr
A1  - Jakubowska-Krepska, Natalia
A1  - Kwasizur, Kinga
A1  - Messyasz, Beata
A1  - Pełechata, Aleksandra
A1  - Pełechaty, Mariusz
A1  - Kokocinski, Mikolaj
A1  - García-Murcia, Ana
A1  - Real, Monserrat
A1  - Romans, Elvira
A1  - Noguero-Ribes, Jordi
A1  - Duque, David Parreño
A1  - Fernández-Morán, Elísabeth
A1  - Karakaya, Nusret
A1  - Häggqvist, Kerstin
A1  - Beklioğlu, Meryem
A1  - Filiz, Nur
A1  - Levi, Eti E.
A1  - Iskin, Uğur
A1  - Bezirci, Gizem
A1  - Tavşanoğlu, Ülkü Nihan
A1  - Özhan, Koray
A1  - Gkelis, Spyros
A1  - Panou, Manthos
A1  - Fakioglu, Özden
A1  - Avagianos, Christos
A1  - Kaloudis, Triantafyllos
A1  - Çelik, Kemal
A1  - Yilmaz, Mete
A1  - Marcé, Rafael
A1  - Catalán, Nuria
A1  - Bravo, Andrea G.
A1  - Buck, Moritz
A1  - Colom-Montero, William
A1  - Mustonen, Kristiina
A1  - Pierson, Don
A1  - Yang, Yang
A1  - Raposeiro, Pedro M.
A1  - Gonçalves, Vítor
A1  - Antoniou, Maria G.
A1  - Tsiarta, Nikoletta
A1  - McCarthy, Valerie
A1  - Perello, Victor C.
A1  - Feldmann, Tõnu
A1  - Laas, Alo
A1  - Panksep, Kristel
A1  - Tuvikene, Lea
A1  - Gagala, Ilona
A1  - Mankiewicz-Boczek, Joana
A1  - Yağcı, Meral Apaydın
A1  - Çınar, Şakir
A1  - Çapkın, Kadir
A1  - Yağcı, Abdulkadir
A1  - Cesur, Mehmet
A1  - Bilgin, Fuat
A1  - Bulut, Cafer
A1  - Uysal, Rahmi
A1  - Obertegger, Ulrike
A1  - Boscaini, Adriano
A1  - Flaim, Giovanna
A1  - Salmaso, Nico
A1  - Cerasino, Leonardo
A1  - Richardson, Jessica
A1  - Visser, Petra M.
A1  - Verspagen, Jolanda M. H.
A1  - Karan, Tünay
A1  - Soylu, Elif Neyran
A1  - Maraşlıoğlu, Faruk
A1  - Napiórkowska-Krzebietke, Agnieszka
A1  - Ochocka, Agnieszka
A1  - Pasztaleniec, Agnieszka
A1  - Antão-Geraldes, Ana M.
A1  - Vasconcelos, Vitor
A1  - Morais, João
A1  - Vale, Micaela
A1  - Köker, Latife
A1  - Akçaalan, Reyhan
A1  - Albay, Meriç
A1  - Maronić, Dubravka Špoljarić
A1  - Stević, Filip
A1  - Pfeiffer, Tanja Žuna
A1  - Fonvielle, Jeremy Andre
A1  - Straile, Dietmar
A1  - Rothhaupt, Karl-Otto
A1  - Hansson, Lars-Anders
A1  - Urrutia-Cordero, Pablo
A1  - Bláha, Luděk
A1  - Geriš, Rodan
A1  - Fránková, Markéta
A1  - Koçer, Mehmet Ali Turan
A1  - Alp, Mehmet Tahir
A1  - Remec-Rekar, Spela
A1  - Elersek, Tina
A1  - Triantis, Theodoros
A1  - Zervou, Sevasti-Kiriaki
A1  - Hiskia, Anastasia
A1  - Haande, Sigrid
A1  - Skjelbred, Birger
A1  - Madrecka, Beata
A1  - Nemova, Hana
A1  - Drastichova, Iveta
A1  - Chomova, Lucia
A1  - Edwards, Christine
A1  - Sevindik, Tuğba Ongun
A1  - Tunca, Hatice
A1  - Önem, Burçin
A1  - Aleksovski, Boris
A1  - Krstić, Svetislav
A1  - Vucelić, Itana Bokan
A1  - Nawrocka, Lidia
A1  - Salmi, Pauliina
A1  - Machado-Vieira, Danielle
A1  - Oliveira, Alinne Gurjão De
A1  - Delgado-Martín, Jordi
A1  - García, David
A1  - Cereijo, Jose Luís
A1  - Gomà, Joan
A1  - Trapote, Mari Carmen
A1  - Vegas-Vilarrúbia, Teresa
A1  - Obrador, Biel
A1  - Grabowska, Magdalena
A1  - Karpowicz, Maciej
A1  - Chmura, Damian
A1  - Úbeda, Bárbara
A1  - Gálvez, José Ángel
A1  - Özen, Arda
A1  - Christoffersen, Kirsten Seestern
A1  - Warming, Trine Perlt
A1  - Kobos, Justyna
A1  - Mazur-Marzec, Hanna
A1  - Pérez-Martínez, Carmen
A1  - Ramos-Rodríguez, Eloísa
A1  - Arvola, Lauri
A1  - Alcaraz-Párraga, Pablo
A1  - Toporowska, Magdalena
A1  - Pawlik-Skowronska, Barbara
A1  - Niedźwiecki, Michał
A1  - Pęczuła, Wojciech
A1  - Leira, Manel
A1  - Hernández, Armand
A1  - Moreno-Ostos, Enrique
A1  - Blanco, José María
A1  - Rodríguez, Valeriano
A1  - Montes-Pérez, Jorge Juan
A1  - Palomino, Roberto L.
A1  - Rodríguez-Pérez, Estela
A1  - Carballeira, Rafael
A1  - Camacho, Antonio
A1  - Picazo, Antonio
A1  - Rochera, Carlos
A1  - Santamans, Anna C.
A1  - Ferriol, Carmen
A1  - Romo, Susana
A1  - Soria, Juan Miguel
A1  - Dunalska, Julita
A1  - Sieńska, Justyna
A1  - Szymański, Daniel
A1  - Kruk, Marek
A1  - Kostrzewska-Szlakowska, Iwona
A1  - Jasser, Iwona
A1  - Žutinić, Petar
A1  - Udovič, Marija Gligora
A1  - Plenković-Moraj, Anđelka
A1  - Frąk, Magdalena
A1  - Bańkowska-Sobczak, Agnieszka
A1  - Wasilewicz, Michał
A1  - Özkan, Korhan
A1  - Maliaka, Valentini
A1  - Kangro, Kersti
A1  - Grossart, Hans-Peter
A1  - Paerl, Hans W.
A1  - Carey, Cayelan C.
A1  - Ibelings, Bas W.
T1  - Temperature effects explain continental scale distribution of cyanobacterial toxins
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1105 
KW  - microcystin
KW  - anatoxin
KW  - cylindrospermopsin
KW  - temperature
KW  - direct effects
KW  - indirect effects
KW  - spatial distribution
KW  - European Multi Lake Survey
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427902
SN  - 1866-8372
IS  - 1105
ER  -