TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Arnison, Paul G.
A1  - Bibb, Mervyn J.
A1  - Bierbaum, Gabriele
A1  - Bowers, Albert A.
A1  - Bugni, Tim S.
A1  - Bulaj, Grzegorz
A1  - Camarero, Julio A.
A1  - Campopiano, Dominic J.
A1  - Challis, Gregory L.
A1  - Clardy, Jon
A1  - Cotter, Paul D.
A1  - Craik, David J.
A1  - Dawson, Michael
A1  - Dittmann-Thünemann, Elke
A1  - Donadio, Stefano
A1  - Dorrestein, Pieter C.
A1  - Entian, Karl-Dieter
A1  - Fischbach, Michael A.
A1  - Garavelli, John S.
A1  - Goeransson, Ulf
A1  - Gruber, Christian W.
A1  - Haft, Daniel H.
A1  - Hemscheidt, Thomas K.
A1  - Hertweck, Christian
A1  - Hill, Colin
A1  - Horswill, Alexander R.
A1  - Jaspars, Marcel
A1  - Kelly, Wendy L.
A1  - Klinman, Judith P.
A1  - Kuipers, Oscar P.
A1  - Link, A. James
A1  - Liu, Wen
A1  - Marahiel, Mohamed A.
A1  - Mitchell, Douglas A.
A1  - Moll, Gert N.
A1  - Moore, Bradley S.
A1  - Mueller, Rolf
A1  - Nair, Satish K.
A1  - Nes, Ingolf F.
A1  - Norris, Gillian E.
A1  - Olivera, Baldomero M.
A1  - Onaka, Hiroyasu
A1  - Patchett, Mark L.
A1  - Piel, Jörn
A1  - Reaney, Martin J. T.
A1  - Rebuffat, Sylvie
A1  - Ross, R. Paul
A1  - Sahl, Hans-Georg
A1  - Schmidt, Eric W.
A1  - Selsted, Michael E.
A1  - Severinov, Konstantin
A1  - Shen, Ben
A1  - Sivonen, Kaarina
A1  - Smith, Leif
A1  - Stein, Torsten
A1  - Suessmuth, Roderich D.
A1  - Tagg, John R.
A1  - Tang, Gong-Li
A1  - Truman, Andrew W.
A1  - Vederas, John C.
A1  - Walsh, Christopher T.
A1  - Walton, Jonathan D.
A1  - Wenzel, Silke C.
A1  - Willey, Joanne M.
A1  - van der Donk, Wilfred A.
T1  - Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature
JF  - Natural product reports : a journal of current developments in bio-organic chemistry
N2  - This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
Y1  - 2013
U6  - https://doi.org/10.1039/c2np20085f
SN  - 0265-0568
VL  - 30
IS  - 1
SP  - 108
EP  - 160
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - de Frenne, Pieter
A1  - Kolb, Annette
A1  - Verheyen, Kris
A1  - Brunet, Johanne
A1  - Chabrerie, Olivier
A1  - Decocq, Guillaume
A1  - Diekmann, Martin
A1  - Eriksson, Ove
A1  - Heinken, Thilo
A1  - Hermy, Martin
A1  - Jõgar, Ülle
A1  - Stanton, Sara
A1  - Quataert, Paul
A1  - Zindel, Renate
A1  - Zobel, Martin
A1  - Graae, Bente Jessen
T1  - Unravelling the effects of temperature, latitude and local environment on the reproduction of forest herbs
N2  - Aim To investigate the effect of temperature, latitude and local environment on the reproductive traits of widespread perennial forest herbs to better understand the potential impacts of rising temperatures on their population dynamics and colonization capacities. Location Six regions along a latitudinal gradient from France to Sweden. Methods Within each region, we collected data from three to five populations of up to six species. For each species, several variables were recorded in each region (temperature, latitude) and population (local abiotic and biotic environmental variables), and seed production and germination were estimated. Resource investment in reproduction (RIR) was quantified as seed number ¥ seed mass, while germinable seed output (GSO) was expressed as seed number ¥ germination percentage.We performed linear regression and mixed effect models to investigate the effects of temperature (growing degree hours), latitude and local abiotic and biotic environment on RIR and GSO. Results Temperature and latitude explained most of the variation in RIR and GSO for early flowering species with a northerly distribution range edge (Anemone nemorosa, Paris quadrifolia and Oxalis acetosella). Reproduction of the more southerly distributed species (Brachypodium sylvaticum, Circaea lutetiana and Primula elatior), in contrast, was independent of temperature/latitude. In the late summer species, B. sylvaticum and C. lutetiana, variation in RIR and GSO was best explained by local environmental variables, while none of the investigated variables appeared to be related to reproduction in P. elatior. Main conclusions We showed that reproduction of only two early flowering, northerly distributed species was related to temperature. This suggests that the potential reproductive response of forest herbs to climate warming partly depends on their phenology and distribution, but also that the response is to some extent species dependent. These findings should be taken into account when predictions about future shifts in distribution range are made.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/journal/118545893/home
U6  - https://doi.org/10.1111/j.1466-8238.2009.00487.x
SN  - 1466-822X
ER  - 
TY  - BOOK
A1  - Mientus, Lukas
A1  - Klempin, Christiane
A1  - Nowak, Anna
A1  - Wyss, Corinne
A1  - Aufschnaiter, Claudia von
A1  - Faix, Ann-Christin
A1  - te Poel, Kathrin
A1  - Wahbe, Nadia
A1  - Pieper, Martin
A1  - Höller, Katharina
A1  - Kallenbach, Lea
A1  - Förster, Magdalena
A1  - Redecker, Anke
A1  - Dick, Mirjam
A1  - Holle, Jörg
A1  - Schneider, Edina
A1  - Rehfeldt, Daniel
A1  - Brauns, Sarah
A1  - Abels, Simone
A1  - Ferencik-Lehmkuhl, Daria
A1  - Fränkel, Silvia
A1  - Frohn, Julia
A1  - Liebsch, Ann-Catherine
A1  - Pech, Detlef
A1  - Schreier, Pascal
A1  - Jessen, Moiken
A1  - Großmann, Uta
A1  - Skintey, Lesya
A1  - Voerkel, Paul
A1  - Vaz Ferreira, Mergenfel A.
A1  - Zimmermann, Jan-Simon
A1  - Buddeberg, Magdalena
A1  - Henke, Vanessa
A1  - Hornberg, Sabine
A1  - Völschow, Yvette
A1  - Warrelmann, Julia-Nadine
A1  - Malek, Jennifer
A1  - Tinnefeld, Anja
A1  - Schmidt, Peggy
A1  - Bauer, Tobias
A1  - Jänisch, Christopher
A1  - Spitzer, Lisa
A1  - Franken, Nadine
A1  - Degeling, Maria
A1  - Preisfeld, Angelika
A1  - Meier, Jana
A1  - Küth, Simon
A1  - Scholl, Daniel
A1  - Vogelsang, Christoph
A1  - Watson, Christina
A1  - Weißbach, Anna
A1  - Kulgemeyer, Christoph
A1  - Oetken, Mandy
A1  - Gorski, Sebastian
A1  - Kubsch, Marcus
A1  - Sorge, Stefan
A1  - Wulff, Peter
A1  - Fellenz, Carolin D.
A1  - Schnell, Susanne
A1  - Larisch, Cathleen
A1  - Kaiser, Franz
A1  - Knott, Christina
A1  - Reimer, Stefanie
A1  - Stegmüller, Nathalie
A1  - Boukrayâa Trabelsi, Kathrin
A1  - Schißlbauer, Franziska
A1  - Lemberger, Lukas
A1  - Barth, Ulrike
A1  - Wiehl, Angelika
A1  - Rogge, Tim
A1  - Böhnke, Anja
A1  - Dietz, Dennis
A1  - Großmann, Leroy
A1  - Wienmeister, Annett
A1  - Zoppke, Till
A1  - Jiang, Lisa
A1  - Grünbauer, Stephanie
A1  - Ostersehlt, Dörte
A1  - Peukert, Sophia
A1  - Schäfer, Christoph
A1  - Löbig, Anna
A1  - Bröll, Leena
A1  - Brandt, Birgit
A1  - Breuer, Meike
A1  - Dausend, Henriette
A1  - Krelle, Michael
A1  - Andersen, Gesine
A1  - Falke, Sascha
A1  - Kindermann-Güzel, Kristin
A1  - Körner, Katrina
A1  - Lottermoser, Lisa-Marie
A1  - Pügner, Kati
A1  - Sonnenburg, Nadine
A1  - Akarsu, Selim
A1  - Rechl, Friederike
A1  - Gadinger, Laureen
A1  - Heinze, Lena
A1  - Wittmann, Eveline
A1  - Franke, Manuela
A1  - Lachmund, Anne-Marie
A1  - Böttger, Julia
A1  - Hannover, Bettina
A1  - Behrendt, Renata
A1  - Conty, Valentina
A1  - Grundmann, Stephanie
A1  - Ghassemi, Novid
A1  - Opitz, Ben
A1  - Brämer, Martin
A1  - Gasparjan, David
A1  - Sambanis, Michaela
A1  - Köster, Hilde
A1  - Lücke, Martin
A1  - Nordmeier, Volkhard
A1  - Schaal, Sonja
A1  - Haberbosch, Maximilian
A1  - Meissner, Maren
A1  - Schaal, Steffen
A1  - Brüchner, Melanie
A1  - Riehle, Tamara
A1  - Leopold, Bengta Marie
A1  - Gerlach, Susanne
A1  - Rau-Patschke, Sarah
A1  - Skorsetz, Nina
A1  - Weber, Nadine
A1  - Damköhler, Jens
A1  - Elsholz, Markus
A1  - Trefzger, Thomas
A1  - Lewek, Tobias
A1  - Borowski, Andreas
ED  - Mientus, Lukas
ED  - Klempin, Christiane
ED  - Nowak, Anna
T1  - Reflexion in der Lehrkräftebildung
BT  - Empirisch – Phasenübergreifend – Interdisziplinär
T3  - Potsdamer Beiträge für Lehrkräftebildung und Bildungsforschung
N2  - Reflexion ist eine Schlüsselkategorie für die professionelle Entwicklung von Lehrkräften, welche als Ausbildungsziel in den Bildungsstandards für die Lehrkräftebildung verankert ist. Eine Verstetigung universitär geprägter Forschung und Modellierung in der praxisnahen Anwendung im schulischen Kontext bietet Potentiale nachhaltiger Professionalisierung. Die Stärkung reflexionsbezogener Kompetenzen durch Empirie und Anwendung scheint eine phasenübergreifende Herausforderung der Lehrkräftebildung zu sein, die es zu bewältigen gilt. Ziele des Tagungsbandes Reflexion in der Lehrkräftebildung sind eine theoretische Schärfung des Konzeptes „Reflexive Professionalisierung“ und der Austausch über Fragen der Einbettung wirksamer reflexionsbezogener Lerngelegenheiten in die Lehrkräftebildung. Forschende und Lehrende der‚ drei Phasen (Studium, Referendariat sowie Fort- und Weiterbildung) der Lehrkräftebildung stellen Lehrkonzepte und Forschungsprojekte zum Thema Reflexion in der Lehrkräftebildung vor und diskutieren diese. Gemeinsam mit Teilnehmenden aller Phasen und von verschiedenen Standorten der Lehrkräftebildung werden zukünftige Herausforderungen identifiziert und Lösungsansätze herausgearbeitet.
T3  - Potsdamer Beiträge zur Lehrkräftebildung und Bildungsforschung - 4 
KW  - Reflexion
KW  - Lehrkräftebildung
KW  - Reflexionskompetenz
KW  - Reflexivität
KW  - Feedback
KW  - Reflection
KW  - Teacher Education
KW  - Reflection Skills
KW  - Reflexivity
KW  - Feedback
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-591717
SN  - 978-3-86956-566-8
SN  - 2626-3556
SN  - 2626-4722
IS  - 4
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - von Loeffelholz, Christian
A1  - Lieske, Stefanie
A1  - Neuschaefer-Rube, Frank
A1  - Willmes, Diana M.
A1  - Raschzok, Nathanael
A1  - Sauer, Igor M.
A1  - König, Jörg
A1  - Fromm, Martin F.
A1  - Horn, Paul
A1  - Chatzigeorgiou, Antonios
A1  - Pathe-Neuschaefer-Rube, Andrea
A1  - Jordan, Jens
A1  - Pfeiffer, Andreas F. H.
A1  - Mingrone, Geltrude
A1  - Bornstein, Stefan R.
A1  - Stroehle, Peter
A1  - Harms, Christoph
A1  - Wunderlich, F. Thomas
A1  - Helfand, Stephen L.
A1  - Bernier, Michel
A1  - de Cabo, Rafael
A1  - Shulman, Gerald I.
A1  - Chavakis, Triantafyllos
A1  - Püschel, Gerhard Paul
A1  - Birkenfeld, Andreas L.
T1  - The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism
BT  - official journal of the American Association for the Study of Liver Diseases
JF  - Hepatology
N2  - Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.
Y1  - 2017
U6  - https://doi.org/10.1002/hep.29089
SN  - 0270-9139
SN  - 1527-3350
VL  - 66
IS  - 2
SP  - 616
EP  - 630
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Middeldorp, Christel M.
A1  - Mahajan, Anubha
A1  - Horikoshi, Momoko
A1  - Robertson, Neil R.
A1  - Beaumont, Robin N.
A1  - Bradfield, Jonathan P.
A1  - Bustamante, Mariona
A1  - Cousminer, Diana L.
A1  - Day, Felix R.
A1  - De Silva, N. Maneka
A1  - Guxens, Monica
A1  - Mook-Kanamori, Dennis O.
A1  - St Pourcain, Beate
A1  - Warrington, Nicole M.
A1  - Adair, Linda S.
A1  - Ahlqvist, Emma
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Ang, Wei
A1  - Atalay, Mustafa
A1  - Auvinen, Juha
A1  - Bartels, Meike
A1  - Beckmann, Jacques S.
A1  - Bilbao, Jose Ramon
A1  - Bond, Tom
A1  - Borja, Judith B.
A1  - Cavadino, Alana
A1  - Charoen, Pimphen
A1  - Chen, Zhanghua
A1  - Coin, Lachlan
A1  - Cooper, Cyrus
A1  - Curtin, John A.
A1  - Custovic, Adnan
A1  - Das, Shikta
A1  - Davies, Gareth E.
A1  - Dedoussis, George V.
A1  - Duijts, Liesbeth
A1  - Eastwood, Peter R.
A1  - Eliasen, Anders U.
A1  - Elliott, Paul
A1  - Eriksson, Johan G.
A1  - Estivill, Xavier
A1  - Fadista, Joao
A1  - Fedko, Iryna O.
A1  - Frayling, Timothy M.
A1  - Gaillard, Romy
A1  - Gauderman, W. James
A1  - Geller, Frank
A1  - Gilliland, Frank
A1  - Gilsanz, Vincente
A1  - Granell, Raquel
A1  - Grarup, Niels
A1  - Groop, Leif
A1  - Hadley, Dexter
A1  - Hakonarson, Hakon
A1  - Hansen, Torben
A1  - Hartman, Catharina A.
A1  - Hattersley, Andrew T.
A1  - Hayes, M. Geoffrey
A1  - Hebebrand, Johannes
A1  - Heinrich, Joachim
A1  - Helgeland, Oyvind
A1  - Henders, Anjali K.
A1  - Henderson, John
A1  - Henriksen, Tine B.
A1  - Hirschhorn, Joel N.
A1  - Hivert, Marie-France
A1  - Hocher, Berthold
A1  - Holloway, John W.
A1  - Holt, Patrick
A1  - Hottenga, Jouke-Jan
A1  - Hypponen, Elina
A1  - Iniguez, Carmen
A1  - Johansson, Stefan
A1  - Jugessur, Astanand
A1  - Kahonen, Mika
A1  - Kalkwarf, Heidi J.
A1  - Kaprio, Jaakko
A1  - Karhunen, Ville
A1  - Kemp, John P.
A1  - Kerkhof, Marjan
A1  - Koppelman, Gerard H.
A1  - Korner, Antje
A1  - Kotecha, Sailesh
A1  - Kreiner-Moller, Eskil
A1  - Kulohoma, Benard
A1  - Kumar, Ashish
A1  - Kutalik, Zoltan
A1  - Lahti, Jari
A1  - Lappe, Joan M.
A1  - Larsson, Henrik
A1  - Lehtimaki, Terho
A1  - Lewin, Alexandra M.
A1  - Li, Jin
A1  - Lichtenstein, Paul
A1  - Lindgren, Cecilia M.
A1  - Lindi, Virpi
A1  - Linneberg, Allan
A1  - Liu, Xueping
A1  - Liu, Jun
A1  - Lowe, William L.
A1  - Lundstrom, Sebastian
A1  - Lyytikainen, Leo-Pekka
A1  - Ma, Ronald C. W.
A1  - Mace, Aurelien
A1  - Magi, Reedik
A1  - Magnus, Per
A1  - Mamun, Abdullah A.
A1  - Mannikko, Minna
A1  - Martin, Nicholas G.
A1  - Mbarek, Hamdi
A1  - McCarthy, Nina S.
A1  - Medland, Sarah E.
A1  - Melbye, Mads
A1  - Melen, Erik
A1  - Mohlke, Karen L.
A1  - Monnereau, Claire
A1  - Morgen, Camilla S.
A1  - Morris, Andrew P.
A1  - Murray, Jeffrey C.
A1  - Myhre, Ronny
A1  - Najman, Jackob M.
A1  - Nivard, Michel G.
A1  - Nohr, Ellen A.
A1  - Nolte, Ilja M.
A1  - Ntalla, Ioanna
A1  - Oberfield, Sharon E.
A1  - Oken, Emily
A1  - Oldehinkel, Albertine J.
A1  - Pahkala, Katja
A1  - Palviainen, Teemu
A1  - Panoutsopoulou, Kalliope
A1  - Pedersen, Oluf
A1  - Pennell, Craig E.
A1  - Pershagen, Goran
A1  - Pitkanen, Niina
A1  - Plomin, Robert
A1  - Power, Christine
A1  - Prasad, Rashmi B.
A1  - Prokopenko, Inga
A1  - Pulkkinen, Lea
A1  - Raikkonen, Katri
A1  - Raitakari, Olli T.
A1  - Reynolds, Rebecca M.
A1  - Richmond, Rebecca C.
A1  - Rivadeneira, Fernando
A1  - Rodriguez, Alina
A1  - Rose, Richard J.
A1  - Salem, Rany
A1  - Santa-Marina, Loreto
A1  - Saw, Seang-Mei
A1  - Schnurr, Theresia M.
A1  - Scott, James G.
A1  - Selzam, Saskia
A1  - Shepherd, John A.
A1  - Simpson, Angela
A1  - Skotte, Line
A1  - Sleiman, Patrick M. A.
A1  - Snieder, Harold
A1  - Sorensen, Thorkild I. A.
A1  - Standl, Marie
A1  - Steegers, Eric A. P.
A1  - Strachan, David P.
A1  - Straker, Leon
A1  - Strandberg, Timo
A1  - Taylor, Michelle
A1  - Teo, Yik-Ying
A1  - Thiering, Elisabeth
A1  - Torrent, Maties
A1  - Tyrrell, Jessica
A1  - Uitterlinden, Andre G.
A1  - van Beijsterveldt, Toos
A1  - van der Most, Peter J.
A1  - van Duijn, Cornelia M.
A1  - Viikari, Jorma
A1  - Vilor-Tejedor, Natalia
A1  - Vogelezang, Suzanne
A1  - Vonk, Judith M.
A1  - Vrijkotte, Tanja G. M.
A1  - Vuoksimaa, Eero
A1  - Wang, Carol A.
A1  - Watkins, William J.
A1  - Wichmann, H-Erich
A1  - Willemsen, Gonneke
A1  - Williams, Gail M.
A1  - Wilson, James F.
A1  - Wray, Naomi R.
A1  - Xu, Shujing
A1  - Xu, Cheng-Jian
A1  - Yaghootkar, Hanieh
A1  - Yi, Lu
A1  - Zafarmand, Mohammad Hadi
A1  - Zeggini, Eleftheria
A1  - Zemel, Babette S.
A1  - Hinney, Anke
A1  - Lakka, Timo A.
A1  - Whitehouse, Andrew J. O.
A1  - Sunyer, Jordi
A1  - Widen, Elisabeth E.
A1  - Feenstra, Bjarke
A1  - Sebert, Sylvain
A1  - Jacobsson, Bo
A1  - Njolstad, Pal R.
A1  - Stoltenberg, Camilla
A1  - Smith, George Davey
A1  - Lawlor, Debbie A.
A1  - Paternoster, Lavinia
A1  - Timpson, Nicholas J.
A1  - Ong, Ken K.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Jaddoe, Vincent W. V.
A1  - Tiemeier, Henning
A1  - Jarvelin, Marjo-Riitta
A1  - Evans, David M.
A1  - Perry, John R. B.
A1  - Grant, Struan F. A.
A1  - Boomsma, Dorret I.
A1  - Freathy, Rachel M.
A1  - McCarthy, Mark I.
A1  - Felix, Janine F.
T1  - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
BT  - design, results and future prospects
JF  - European journal of epidemiology
N2  - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
KW  - Genetics
KW  - Consortium
KW  - Childhood traits and disorders
KW  - Longitudinal
Y1  - 2019
U6  - https://doi.org/10.1007/s10654-019-00502-9
SN  - 0393-2990
SN  - 1573-7284
VL  - 34
IS  - 3
SP  - 279
EP  - 300
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Zhang, Shanshan
A1  - Hosseini, Seyed Mehrdad
A1  - Gunder, Rene
A1  - Petsiuk, Andrei
A1  - Caprioglio, Pietro
A1  - Wolff, Christian Michael
A1  - Shoaee, Safa
A1  - Meredith, Paul
A1  - Schorr, Susan
A1  - Unold, Thomas
A1  - Burn, Paul L.
A1  - Neher, Dieter
A1  - Stolterfoht, Martin
T1  - The Role of Bulk and Interface Recombination in High-Efficiency Low-Dimensional Perovskite Solar Cells
JF  - Advanced materials
N2  - 2D Ruddlesden-Popper perovskite (RPP) solar cells have excellent environmental stability. However, the power conversion efficiency (PCE) of RPP cells remains inferior to 3D perovskite-based cells. Herein, 2D (CH3(CH2)(3)NH3)(2)(CH3NH3)(n-1)PbnI3n+1 perovskite cells with different numbers of [PbI6](4-) sheets (n = 2-4) are analyzed. Photoluminescence quantum yield (PLQY) measurements show that nonradiative open-circuit voltage (V-OC) losses outweigh radiative losses in materials with n > 2. The n = 3 and n = 4 films exhibit a higher PLQY than the standard 3D methylammonium lead iodide perovskite although this is accompanied by increased interfacial recombination at the top perovskite/C-60 interface. This tradeoff results in a similar PLQY in all devices, including the n = 2 system where the perovskite bulk dominates the recombination properties of the cell. In most cases the quasi-Fermi level splitting matches the device V-OC within 20 meV, which indicates minimal recombination losses at the metal contacts. The results show that poor charge transport rather than exciton dissociation is the primary reason for the reduction in fill factor of the RPP devices. Optimized n = 4 RPP solar cells had PCEs of 13% with significant potential for further improvements.
KW  - 2D perovskites
KW  - interface recombination
KW  - perovskite solar cells
KW  - photoluminescence
KW  - V-OC loss
Y1  - 2019
U6  - https://doi.org/10.1002/adma.201901090
SN  - 0935-9648
SN  - 1521-4095
VL  - 31
IS  - 30
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Yazmaciyan, Aren
A1  - Stolterfoht, Martin
A1  - Burn, Paul L.
A1  - Lin, Qianqian
A1  - Meredith, Paul
A1  - Armin, Ardalan
T1  - Recombination losses above and below the transport percolation threshold in bulk heterojunction organic solar cells
JF  - Advanced energy materials
N2  - Achieving the highest power conversion efficiencies in bulk heterojunction organic solar cells requires a morphology that delivers electron and hole percolation pathways for optimized transport, plus sufficient donor:acceptor contact area for near unity charge transfer state formation. This is a significant structural challenge, particularly in semiconducting polymer:fullerene systems. This balancing act in the model high efficiency PTB7:PC70BM blend is studied by tuning the donor:acceptor ratio, with a view to understanding the recombination loss mechanisms above and below the fullerene transport percolation threshold. The internal quantum efficiency is found to be strongly correlated to the slower carrier mobility in agreement with other recent studies. Furthermore, second-order recombination losses dominate the shape of the current density-voltage curve in efficient blend combinations, where the fullerene phase is percolated. However, below the charge transport percolation threshold, there is an electric-field dependence of first-order losses, which includes electric-field-dependent photogeneration. In the intermediate regime, the fill factor appears to be limited by both first- and second-order losses. These findings provide additional basic understanding of the interplay between the bulk heterojunction morphology and the order of recombination in organic solar cells. They also shed light on the limitations of widely used transport models below the percolation threshold.
KW  - bulk heterojunctions
KW  - charge transport
KW  - organic solar cells
KW  - percolation threshold
KW  - recombination losses
Y1  - 2018
U6  - https://doi.org/10.1002/aenm.201703339
SN  - 1614-6832
SN  - 1614-6840
VL  - 8
IS  - 18
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Zhang, Shanshan
A1  - Stolterfoht, Martin
A1  - Armin, Ardalan
A1  - Lin, Qianqian
A1  - Zu, Fengshuo
A1  - Sobus, Jan
A1  - Jin, Hui
A1  - Koch, Norbert
A1  - Meredith, Paul
A1  - Burn, Paul L.
A1  - Neher, Dieter
T1  - Interface Engineering of Solution-Processed Hybrid Organohalide Perovskite Solar Cells
JF  - ACS applied materials & interfaces
N2  - Engineering the interface between the perovskite absorber and the charge-transporting layers has become an important method for improving the charge extraction and open-circuit voltage (V-OC) of hybrid perovskite solar cells. Conjugated polymers are particularly suited to form the hole-transporting layer, but their hydrophobicity renders it difficult to solution-process the perovskite absorber on top. Herein, oxygen plasma treatment is introduced as a simple means to change the surface energy and work function of hydrophobic polymer interlayers for use as p-contacts in perovskite solar cells. We find that upon oxygen plasma treatment, the hydrophobic surfaces of different prototypical p-type polymers became sufficiently hydrophilic to enable subsequent perovskite junction processing. In addition, the oxygen plasma treatment also increased the ionization potential of the polymer such that it became closer to the valance band energy of the perovskite. It was also found that the oxygen plasma treatment could increase the electrical conductivity of the p-type polymers, facilitating more efficient charge extraction. On the basis of this concept, inverted MAPbI(3) perovskite devices with different oxygen plasma-treated polymers such as P3HT, P3OT, polyTPD, or PTAA were fabricated with power conversion efficiencies of up to 19%.
KW  - organohalide lead perovskites
KW  - solar cells
KW  - surface wetting
KW  - work function
KW  - oxygen plasma
KW  - transport layer
Y1  - 2018
U6  - https://doi.org/10.1021/acsami.8b02503
SN  - 1944-8244
VL  - 10
IS  - 25
SP  - 21681
EP  - 21687
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Stolterfoht, Martin
A1  - Wolff, Christian Michael
A1  - Marquez, Jose A.
A1  - Zhang, Shanshan
A1  - Hages, Charles J.
A1  - Rothhardt, Daniel
A1  - Albrecht, Steve
A1  - Burn, Paul L.
A1  - Meredith, Paul
A1  - Unold, Thomas
A1  - Neher, Dieter
T1  - Visualization and suppression of interfacial recombination for high-efficiency large-area pin perovskite solar cells
JF  - Nature Energy
N2  - The performance of perovskite solar cells is predominantly limited by non-radiative recombination, either through trap-assisted recombination in the absorber layer or via minority carrier recombination at the perovskite/transport layer interfaces. Here, we use transient and absolute photoluminescence imaging to visualize all non-radiative recombination pathways in planar pintype perovskite solar cells with undoped organic charge transport layers. We find significant quasi-Fermi-level splitting losses (135 meV) in the perovskite bulk, whereas interfacial recombination results in an additional free energy loss of 80 meV at each individual interface, which limits the open-circuit voltage (V-oc) of the complete cell to similar to 1.12 V. Inserting ultrathin interlayers between the perovskite and transport layers leads to a substantial reduction of these interfacial losses at both the p and n contacts. Using this knowledge and approach, we demonstrate reproducible dopant-free 1 cm(2) perovskite solar cells surpassing 20% efficiency (19.83% certified) with stabilized power output, a high V-oc (1.17 V) and record fill factor (>81%).
KW  - Energy science and technology
KW  - Solar cells
Y1  - 2018
U6  - https://doi.org/10.1038/s41560-018-0219-8
SN  - 2058-7546
VL  - 3
IS  - 10
SP  - 847
EP  - 854
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - BOOK
A1  - Hüttenrauch, Stefan
A1  - Kylau, Uwe
A1  - Grund, Martin
A1  - Queck, Tobias
A1  - Ploskonos, Anna
A1  - Schreiter, Torben
A1  - Breest, Martin
A1  - Haubrock, Sören
A1  - Bouche, Paul
T1  - Fundamentals of Service-Oriented Engineering
BT  - Proceedings of the Fall 2006 Workshop of the HPI Research School on Service-Oriented Systems Engineering
T3  - Technische Berichte des Hasso-Plattner-Instituts für Softwaresystemtechnik an der Universität Potsdam
Y1  - 2006
SN  - 3-939469-35-1
SN  - 1613-5652
VL  - 18
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Hetenyi, Gyorgy
A1  - Molinari, Irene
A1  - Clinton, John
A1  - Bokelmann, Gotz
A1  - Bondar, Istvan
A1  - Crawford, Wayne C.
A1  - Dessa, Jean-Xavier
A1  - Doubre, Cecile
A1  - Friederich, Wolfgang
A1  - Fuchs, Florian
A1  - Giardini, Domenico
A1  - Graczer, Zoltan
A1  - Handy, Mark R.
A1  - Herak, Marijan
A1  - Jia, Yan
A1  - Kissling, Edi
A1  - Kopp, Heidrun
A1  - Korn, Michael
A1  - Margheriti, Lucia
A1  - Meier, Thomas
A1  - Mucciarelli, Marco
A1  - Paul, Anne
A1  - Pesaresi, Damiano
A1  - Piromallo, Claudia
A1  - Plenefisch, Thomas
A1  - Plomerova, Jaroslava
A1  - Ritter, Joachim
A1  - Rumpker, Georg
A1  - Sipka, Vesna
A1  - Spallarossa, Daniele
A1  - Thomas, Christine
A1  - Tilmann, Frederik
A1  - Wassermann, Joachim
A1  - Weber, Michael
A1  - Weber, Zoltan
A1  - Wesztergom, Viktor
A1  - Zivcic, Mladen
A1  - Abreu, Rafael
A1  - Allegretti, Ivo
A1  - Apoloner, Maria-Theresia
A1  - Aubert, Coralie
A1  - Besancon, Simon
A1  - de Berc, Maxime Bes
A1  - Brunel, Didier
A1  - Capello, Marco
A1  - Carman, Martina
A1  - Cavaliere, Adriano
A1  - Cheze, Jerome
A1  - Chiarabba, Claudio
A1  - Cougoulat, Glenn
A1  - Cristiano, Luigia
A1  - Czifra, Tibor
A1  - Danesi, Stefania
A1  - Daniel, Romuald
A1  - Dannowski, Anke
A1  - Dasovic, Iva
A1  - Deschamps, Anne
A1  - Egdorf, Sven
A1  - Fiket, Tomislav
A1  - Fischer, Kasper
A1  - Funke, Sigward
A1  - Govoni, Aladino
A1  - Groschl, Gidera
A1  - Heimers, Stefan
A1  - Heit, Ben
A1  - Herak, Davorka
A1  - Huber, Johann
A1  - Jaric, Dejan
A1  - Jedlicka, Petr
A1  - Jund, Helene
A1  - Klingen, Stefan
A1  - Klotz, Bernhard
A1  - Kolinsky, Petr
A1  - Kotek, Josef
A1  - Kuhne, Lothar
A1  - Kuk, Kreso
A1  - Lange, Dietrich
A1  - Loos, Jurgen
A1  - Lovati, Sara
A1  - Malengros, Deny
A1  - Maron, Christophe
A1  - Martin, Xavier
A1  - Massa, Marco
A1  - Mazzarini, Francesco
A1  - Metral, Laurent
A1  - Moretti, Milena
A1  - Munzarova, Helena
A1  - Nardi, Anna
A1  - Pahor, Jurij
A1  - Pequegnat, Catherine
A1  - Petersen, Florian
A1  - Piccinini, Davide
A1  - Pondrelli, Silvia
A1  - Prevolnik, Snjezan
A1  - Racine, Roman
A1  - Regnier, Marc
A1  - Reiss, Miriam
A1  - Salimbeni, Simone
A1  - Santulin, Marco
A1  - Scherer, Werner
A1  - Schippkus, Sven
A1  - Schulte-Kortnack, Detlef
A1  - Solarino, Stefano
A1  - Spieker, Kathrin
A1  - Stipcevic, Josip
A1  - Strollo, Angelo
A1  - Sule, Balint
A1  - Szanyi, Gyongyver
A1  - Szucs, Eszter
A1  - Thorwart, Martin
A1  - Ueding, Stefan
A1  - Vallocchia, Massimiliano
A1  - Vecsey, Ludek
A1  - Voigt, Rene
A1  - Weidle, Christian
A1  - Weyland, Gauthier
A1  - Wiemer, Stefan
A1  - Wolf, Felix
A1  - Wolyniec, David
A1  - Zieke, Thomas
T1  - The AlpArray seismic network
BT  - a large-scale european experiment to image the alpine orogen
JF  - Surveys in Geophysics
N2  - The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.
KW  - Seismology
KW  - Alps
KW  - Seismic network
KW  - Geodynamics
KW  - Seismic imaging
KW  - Mountain building
Y1  - 2018
U6  - https://doi.org/10.1007/s10712-018-9472-4
SN  - 0169-3298
SN  - 1573-0956
VL  - 39
IS  - 5
SP  - 1009
EP  - 1033
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - BOOK
A1  - Breest, Martin
A1  - Bouché, Paul
A1  - Grund, Martin
A1  - Haubrock, Sören
A1  - Hüttenrauch, Stefan
A1  - Kylau, Uwe
A1  - Ploskonos, Anna
A1  - Queck, Tobias
A1  - Schreiter, Torben
T1  - Fundamentals of Service-Oriented Engineering
N2  - Since 2002, keywords like service-oriented engineering, service-oriented computing, and service-oriented architecture have been widely used in research, education, and enterprises. These and related terms are often misunderstood or used incorrectly. To correct these misunderstandings, a deeper knowledge of the concepts, the historical backgrounds, and an overview of service-oriented architectures is demanded and given in this paper.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 16 
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-33801
SN  - 978-3-939469-35-3
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - van der Plas, Fons
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Renner, Swen C.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Boch, Steffen
A1  - Böhm, Stefan
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Heinze, Johannes
A1  - Hölzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schöning, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Türke, Manfred
A1  - Venter, Paul C.
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality
JF  - Nature : the international weekly journal of science
Y1  - 2016
U6  - https://doi.org/10.1038/nature19092
SN  - 0028-0836
SN  - 1476-4687
VL  - 536
SP  - 456
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Morris, Paul J.
A1  - Bohdan, Artem
A1  - Weidl, Martin S.
A1  - Tsirou, Michelle
A1  - Fulat, Karol
A1  - Pohl, Martin
T1  - Pre-acceleration in the electron foreshock. II. oblique whistler waves
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - Thermal electrons have gyroradii many orders of magnitude smaller than the finite width of a shock, thus need to be pre-accelerated before they can cross it and be accelerated by diffusive shock acceleration. One region where pre-acceleration may occur is the inner foreshock, which upstream electrons must pass through before any potential downstream crossing. In this paper, we perform a large-scale particle-in-cell simulation that generates a single shock with parameters motivated from supernova remnants. Within the foreshock, reflected electrons excite the oblique whistler instability and produce electromagnetic whistler waves, which comove with the upstream flow and as nonlinear structures eventually reach radii of up to 5 ion-gyroradii. We show that the inner electromagnetic configuration of the whistlers evolves into complex nonlinear structures bound by a strong magnetic field around four times the upstream value. Although these nonlinear structures do not in general interact with cospatial upstream electrons, they resonate with electrons that have been reflected at the shock. We show that they can scatter, or even trap, reflected electrons, confining around 0.8% of the total upstream electron population to the region close to the shock where they can undergo substantial pre-acceleration. This acceleration process is similar to, yet approximately three times more efficient than, stochastic shock drift acceleration.
Y1  - 2023
U6  - https://doi.org/10.3847/1538-4357/acaec8
SN  - 0004-637X
SN  - 1538-4357
VL  - 944
IS  - 1
PB  - Institute of Physics Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Morris, Paul J.
A1  - Bohdan, Artem
A1  - Weidl, Martin S.
A1  - Pohl, Martin
T1  - Preacceleration in the Electron Foreshock. I. Electron Acoustic Waves
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - To undergo diffusive shock acceleration, electrons need to be preaccelerated to increase their energies by several orders of magnitude, else their gyroradii will be smaller than the finite width of the shock. In oblique shocks, where the upstream magnetic field orientation is neither parallel nor perpendicular to the shock normal, electrons can escape to the shock upstream, modifying the shock foot to a region called the electron foreshock. To determine the preacceleration in this region, we undertake particle-in-cell simulations of oblique shocks while varying the obliquity and in-plane angles. We show that while the proportion of reflected electrons is negligible for theta (Bn) = 74.degrees 3, it increases to R similar to 5% for theta (Bn) = 30 degrees, and that, via the electron acoustic instability, these electrons power electrostatic waves upstream with energy density proportional to R (0.6) and a wavelength approximate to 2 lambda (se), where lambda (se) is the electron skin length. While the initial reflection mechanism is typically a combination of shock-surfing acceleration and magnetic mirroring, we show that once the electrostatic waves have been generated upstream, they themselves can increase the momenta of upstream electrons parallel to the magnetic field. In less than or similar to 1% of cases, upstream electrons are prematurely turned away from the shock and never injected downstream. In contrast, a similar fraction is rescattered back toward the shock after reflection, reinteracts with the shock with energies much greater than thermal, and crosses into the downstream.
Y1  - 2022
U6  - https://doi.org/10.3847/1538-4357/ac69c7
SN  - 0004-637X
SN  - 1538-4357
VL  - 931
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Bluethgen, Nico
A1  - Boch, Steffen
A1  - Boehm, Stefan
A1  - Boerschig, Carmen
A1  - Buscot, Francois
A1  - Diekoetter, Tim
A1  - Heinze, Johannes
A1  - Hoelzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Klein, Alexandra-Maria
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Mueller, Joerg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schoening, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Tuerke, Manfred
A1  - Venter, Paul
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Locally rare species influence grassland ecosystem multifunctionality
JF  - Philosophical transactions of the Royal Society of London : B, Biological sciences
N2  - Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities.
KW  - biodiversity
KW  - common species
KW  - ecosystem function
KW  - identity hypothesis
KW  - land use
KW  - multitrophic
Y1  - 2016
U6  - https://doi.org/10.1098/rstb.2015.0269
SN  - 0962-8436
SN  - 1471-2970
VL  - 371
SP  - 3175
EP  - 3185
PB  - Royal Society
CY  - London
ER  - 
TY  - JOUR
A1  - Thomas, Jessica E.
A1  - Carvalho, Gary R.
A1  - Haile, James
A1  - Rawlence, Nicolas J.
A1  - Martin, Michael D.
A1  - Ho, Simon Y. W.
A1  - Sigfusson, Arnor P.
A1  - Josefsson, Vigfus A.
A1  - Frederiksen, Morten
A1  - Linnebjerg, Jannie F.
A1  - Castruita, Jose A. Samaniego
A1  - Niemann, Jonas
A1  - Sinding, Mikkel-Holger S.
A1  - Sandoval-Velasco, Marcela
A1  - Soares, Andre E. R.
A1  - Lacy, Robert
A1  - Barilaro, Christina
A1  - Best, Juila
A1  - Brandis, Dirk
A1  - Cavallo, Chiara
A1  - Elorza, Mikelo
A1  - Garrett, Kimball L.
A1  - Groot, Maaike
A1  - Johansson, Friederike
A1  - Lifjeld, Jan T.
A1  - Nilson, Goran
A1  - Serjeanston, Dale
A1  - Sweet, Paul
A1  - Fuller, Errol
A1  - Hufthammer, Anne Karin
A1  - Meldgaard, Morten
A1  - Fjeldsa, Jon
A1  - Shapiro, Beth
A1  - Hofreiter, Michael
A1  - Stewart, John R.
A1  - Gilbert, M. Thomas P.
A1  - Knapp, Michael
T1  - Demographic reconstruction from ancient DNA supports rapid extinction of the great auk
JF  - eLife
N2  - The great auk was once abundant and distributed across the North Atlantic. It is now extinct, having been heavily exploited for its eggs, meat, and feathers. We investigated the impact of human hunting on its demise by integrating genetic data, GPS-based ocean current data, and analyses of population viability. We sequenced complete mitochondrial genomes of 41 individuals from across the species' geographic range and reconstructed population structure and population dynamics throughout the Holocene. Taken together, our data do not provide any evidence that great auks were at risk of extinction prior to the onset of intensive human hunting in the early 16th century. In addition, our population viability analyses reveal that even if the great auk had not been under threat by environmental change, human hunting alone could have been sufficient to cause its extinction. Our results emphasise the vulnerability of even abundant and widespread species to intense and localised exploitation.
Y1  - 2019
U6  - https://doi.org/10.7554/eLife.47509
SN  - 2050-084X
VL  - 8
PB  - eLife Sciences Publications
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Hani, Maan H.
A1  - Sparre, Martin
A1  - Ellison, Sara L.
A1  - Torrey, Paul
A1  - Vogelsberger, Mark
T1  - Galaxy mergers moulding the circum-galactic medium
BT  - I. The impact of a major merger
JF  - Monthly notices of the Royal Astronomical Society
N2  - Galaxies are surrounded by sizeable gas reservoirs which host a significant amount of metals: the circum-galactic medium (CGM). The CGM acts as a mediator between the galaxy and the extragalactic medium. However, our understanding of how galaxy mergers, a major evolutionary transformation, impact the CGM remains deficient. We present a theoretical study of the effect of galaxy mergers on the CGM. We use hydrodynamical cosmological zoom-in simulations of a major merger selected from the Illustris project such that the z = 0 descendant has a halo mass and stellar mass comparable to the Milky Way. To study the CGM we then re-simulated this system at a 40 times better mass resolution, and included detailed post-processing ionization modelling. Our work demonstrates the effect the merger has on the characteristic size of the CGM, its metallicity, and the predicted covering fraction of various commonly observed gas-phase species, such as H I, C IV, and O VI. We show that merger-induced outflows can increase the CGM metallicity by 0.2-0.3 dex within 0.5 Gyr post-merger. These effects last up to 6 Gyr post-merger. While the merger increases the total metal covering fractions by factors of 2-3, the covering fractions of commonly observed UV ions decrease due to the hard ionizing radiation from the active galactic nucleus, which we model explicitly. Our study of the single simulated major merger presented in this work demonstrates the significant impact that a galaxy interaction can have on the size, metallicity, and observed column densities of the CGM.
KW  - methods: numerical
KW  - galaxies: evolution
KW  - galaxies: haloes
KW  - galaxies: interactions
Y1  - 2017
U6  - https://doi.org/10.1093/mnras/stx3252
SN  - 0035-8711
SN  - 1365-2966
VL  - 475
IS  - 1
SP  - 1160
EP  - 1176
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - GEN
A1  - Püschel, Gerhard Paul
A1  - Oppermann, Martin
A1  - Neuschäfer-Rube, Frank
A1  - Götze, Otto
A1  - Jungermann, Kurt
T1  - Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion : the periportal scavenger cell hypothesis
N2  - 1) During orthograde perfusion of rat liver human anaphylatoxin C3a caused an increase in glucose and lactate output and reduction of flow. These effects could be enhanced nearly twofold by co-infusion of the carboxypeptidase inhibitor MERGETPA, which reduced inactivation of C3a to C3adesArg. 2) During retrograde perfusion C3a caused a two- to threefold larger increase in glucose and lactate output and reduction of flow than in orthograde perfusions. These actions tended to be slightly enhanced by MERGETPA. 3) The elimination of C3a plus C3adesArg immunoreactivity during a single liver passage was around 67%, irrespective of the perfusion direction and the presence of the carboxypeptidase inhibitor MERGETPA; however, less C3adesArg and more intact C3a appeared in the perfusate in the presence of MERGETPA in orthograde and retrogade perfusions It is concluded that rat liver inactivated human anaphylatoxin C3a by conversion to C3adesArg and moreover eliminated it by an additional process. The inactivation to C3adesArg seemed to be located predominantly in the proximal periportal region of the liver sinusoid, since C3a was less effective in orthograde perfusions, when C3a first passed the proximal periportal region before reaching the predominant mass of parenchyma as its site of action, than in retrograde perfusions, when it first passed the perivenous area. These data may be evidence for a periportal scavenger mechanism, by which the liver protects itself from systemically released mediators of inflammation that interfere with the local regulation of liver metabolism and hemodynamics.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 040 
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16747
ER  - 
TY  - GEN
A1  - Püschel, Gerhard Paul
A1  - Oppermann, Martin
A1  - Muschol, Waldemar
A1  - Götze, Otto
A1  - Jungermann, Kurt
T1  - Increase of glucose and lactate output and decrease of flow by human anaphylatoxin C3a but not C5a in perfused rat liver
N2  - The complement fragments C3a and C5a were purified from zymosan-activated human serum by column chromatographic procedures after the bulk of the proteins had been removed by acidic polyethylene glycol precipitation. In the isolated in situ perfused rat liver C3a increased glucose and lactate output and reduced flow. Its effects were enhanced in the presence of the carboxypeptidase inhibitor DL-mercaptomethyl-3-guanidinoethylthio-propanoic acid (MERGETPA) and abolished by preincubation of the anaphylatoxin with carboxypeptidase B or with Fab fragments of an anti-C3a monoclonal antibody. The C3a effects were partially inhibited by the thromboxane antagonist BM13505. C5a had no effect. It is concluded that locally but not systemically produced C3a may play an important role in the regulation of local metabolism and hemodynamics during inflammatory processes in the liver.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 039 
KW  - Hepatic glucose balance
KW  - Hepatic lactate balance
KW  - Hepatic hemodynamics
KW  - Complement system
KW  - Anaphylatoxin
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16733
ER  - 
TY  - JOUR
A1  - Buratti, Bonnie J.
A1  - Thomas, P. C.
A1  - Roussos, E.
A1  - Howett, Carly
A1  - Seiss, Martin
A1  - Hendrix, A. R.
A1  - Helfenstein, Paul
A1  - Brown, R. H.
A1  - Clark, R. N.
A1  - Denk, Tilmann
A1  - Filacchione, Gianrico
A1  - Hoffmann, Holger
A1  - Jones, Geraint H.
A1  - Khawaja, N.
A1  - Kollmann, Peter
A1  - Krupp, Norbert
A1  - Lunine, Jonathan
A1  - Momary, T. W.
A1  - Paranicas, Christopher
A1  - Postberg, Frank
A1  - Sachse, Manuel
A1  - Spahn, Frank
A1  - Spencer, John
A1  - Srama, Ralf
A1  - Albin, T.
A1  - Baines, K. H.
A1  - Ciarniello, Mauro
A1  - Economou, Thanasis
A1  - Hsu, Hsiang-Wen
A1  - Kempf, Sascha
A1  - Krimigis, Stamatios M.
A1  - Mitchell, Donald
A1  - Moragas-Klostermeyer, Georg
A1  - Nicholson, Philip D.
A1  - Porco, C. C.
A1  - Rosenberg, Heike
A1  - Simolka, Jonas
A1  - Soderblom, Laurence A.
T1  - Close Cassini flybys of Saturn’s ring moons Pan, Daphnis, Atlas, Pandora, and Epimetheus
JF  - Science
N2  - Saturn’s main ring system is associated with a set of small moons that either are embedded within it or interact with the rings to alter their shape and composition. Five close flybys of the moons Pan, Daphnis, Atlas, Pandora, and Epimetheus were performed between December 2016 and April 2017 during the ring-grazing orbits of the Cassini mission. Data on the moons’ morphology, structure, particle environment, and composition were returned, along with images in the ultraviolet and thermal infrared. We find that the optical properties of the moons’ surfaces are determined by two competing processes: contamination by a red material formed in Saturn’s main ring system and accretion of bright icy particles or water vapor from volcanic plumes originating on the moon Enceladus.
Y1  - 2019
U6  - https://doi.org/10.1126/science.aat2349
SN  - 0036-8075
SN  - 1095-9203
VL  - 364
IS  - 6445
SP  - 1053
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Chang, Dan
A1  - Knapp, Michael
A1  - Enk, Jacob
A1  - Lippold, Sebastian
A1  - Kircher, Martin
A1  - Lister, Adrian M.
A1  - MacPhee, Ross D. E.
A1  - Widga, Christopher
A1  - Czechowski, Paul
A1  - Sommer, Robert
A1  - Hodges, Emily
A1  - Stümpel, Nikolaus
A1  - Barnes, Ian
A1  - Dalén, Love
A1  - Derevianko, Anatoly
A1  - Germonpré, Mietje
A1  - Hillebrand-Voiculescu, Alexandra
A1  - Constantin, Silviu
A1  - Kuznetsova, Tatyana
A1  - Mol, Dick
A1  - Rathgeber, Thomas
A1  - Rosendahl, Wilfried
A1  - Tikhonov, Alexey N.
A1  - Willerslev, Eske
A1  - Hannon, Greg
A1  - Lalueza i Fox, Carles
A1  - Joger, Ulrich
A1  - Poinar, Hendrik N.
A1  - Hofreiter, Michael
A1  - Shapiro, Beth
T1  - The evolutionary and phylogeographic history of woolly mammoths
BT  - a comprehensive mitogenomic analysis
JF  - Scientific reports
N2  - Near the end of the Pleistocene epoch, populations of the woolly mammoth (Mammuthus primigenius) were distributed across parts of three continents, from western Europe and northern Asia through Beringia to the Atlantic seaboard of North America. Nonetheless, questions about the connectivity and temporal continuity of mammoth populations and species remain unanswered. We use a combination of targeted enrichment and high-throughput sequencing to assemble and interpret a data set of 143 mammoth mitochondrial genomes, sampled from fossils recovered from across their Holarctic range. Our dataset includes 54 previously unpublished mitochondrial genomes and significantly increases the coverage of the Eurasian range of the species. The resulting global phylogeny confirms that the Late Pleistocene mammoth population comprised three distinct mitochondrial lineages that began to diverge ~1.0–2.0 million years ago (Ma). We also find that mammoth mitochondrial lineages were strongly geographically partitioned throughout the Pleistocene. In combination, our genetic results and the pattern of morphological variation in time and space suggest that male-mediated gene flow, rather than large-scale dispersals, was important in the Pleistocene evolutionary history of mammoths.
Y1  - 2017
U6  - https://doi.org/10.1038/srep44585
SN  - 2045-2322
VL  - 7
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Neuschäfer-Rube, Frank
A1  - Oppermann, Martin
A1  - Möller, Ulrike
A1  - Böer, Ulrike
A1  - Püschel, Gerhard Paul
T1  - Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid
N2  - Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain, which also confers desensitization in a G(i)-coupled rEP3hEP4 carboxyl-terminal domain receptor hybrid (rEP3hEP4-Ct-R). To elucidate the possible mechanism of this desensitization, in vivo phosphorylation stimulated by activators of second messenger kinases, by prostaglandin E(2), or by the EP3-R agonist M&B28767 was investigated in COS-7 cells expressing FLAG-epitope-tagged rat EP3beta-R (rEP3beta-R), hEP4-R, or rEP3hEP4- Ct-R. Stimulation of protein kinase C with phorbol-12-myristate-13-acetate led to a slight phosphorylation of the FLAG- rEP3beta-R but to a strong phosphorylation of the FLAG-hEP4-R and the FLAG-rEP3hEP4-Ct-R, which was suppressed by the protein kinase A and protein kinase C inhibitor staurosporine. Prostaglandin E(2) stimulated phosphorylation of the FLAG- hEP4-R in its carboxyl-terminal receptor domain. The EP3-R agonist M&B28767 induced a time- and dose-dependent phosphorylation of the FLAG-rEP3hEP4-Ct-R but not of the FLAG-rEP3beta-R. Agonist-induced phosphorylation of the FLAG- hEP4-R and the FLAG-rEP3hEP4-Ct-R were not inhibited by staurosporine, which implies a role of G protein-coupled receptor kinases (GRKs) in agonist-induced receptor phosphorylation. Overexpression of GRKs in FLAG-rEP3hEP4-Ct-R- expressing COS-7 cells augmented the M&B28767-induced receptor phosphorylation and receptor sequestration. These findings indicate that phosphorylation of the carboxyl-terminal hEP4-R domain possibly by GRKs but not by second messenger kinases may be involved in rapid agonist-induced desensitization of the hEP4-R and the rEP3hEP4-Ct-R.
Y1  - 1999
SN  - 1521-0111
ER  - 
TY  - JOUR
A1  - Henkel, Janin
A1  - Coleman, Charles Dominic
A1  - Schraplau, Anne
A1  - Jöhrens, Korinna
A1  - Weber, Daniela
A1  - Castro, Jose Pedro
A1  - Hugo, Martin
A1  - Schulz, Tim Julius
A1  - Krämer, Stephanie
A1  - Schürmann, Annette
A1  - Püschel, Gerhard Paul
T1  - Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol
JF  - Molecular medicine
N2  - Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g., high-fat diets) or overweight and insulin resistance (e.g., methionine-choline-deficient diets), or they are based on monogenetic defects (e.g., ob/ob mice). In the current study, a Western-type diet containing soybean oil with high n-6-PUFA and 0.75% cholesterol (SOD + Cho) induced steatosis, inflammation and fibrosis accompanied by hepatic lipid peroxidation and oxidative stress in livers of C57BL/6-mice, which in addition showed increased weight gain and insulin resistance, thus displaying a phenotype closely resembling all clinical features of NASH in patients with metabolic syndrome. In striking contrast, a soybean oil-containing Western-type diet without cholesterol (SOD) induced only mild steatosis but not hepatic inflammation, fibrosis, weight gain or insulin resistance. Another high-fat diet, mainly consisting of lard and supplemented with fructose in drinking water (LAD + Fru), resulted in more prominent weight gain, insulin resistance and hepatic steatosis than SOD + Cho, but livers were devoid of inflammation and fibrosis. Although both LAD + Fru-and SOD + Cho-fed animals had high plasma cholesterol, liver cholesterol was elevated only in SOD + Cho animals. Cholesterol induced expression of chemotactic and inflammatory cytokines in cultured Kupffer cells and rendered hepatocytes more susceptible to apoptosis. In summary, dietary cholesterol in the SOD + Cho diet may trigger hepatic inflammation and fibrosis. SOD + Cho-fed animals may be a useful disease model displaying many clinical features of patients with the metabolic syndrome and NASH.
KW  - Nonalcoholic Steatohepatitis (NASH)
KW  - Typical Western Diet
KW  - Nonalcoholic Fatty Liver Disease (NAFLD)
KW  - Dietary Cholesterol
KW  - Kupffer Cells
Y1  - 2017
U6  - https://doi.org/10.2119/molmed.2016.00203
SN  - 1076-1551
SN  - 1528-3658
VL  - 23
SP  - 70
EP  - 82
PB  - Feinstein Inst. for Medical Research
CY  - Manhasset
ER  - 
TY  - GEN
A1  - Martin, Paul
T1  - Afrika im 21. Jahrhundert : eine zu schreibende Erfolgsgeschichte
T1  - Africa in the 21st century : building a success story
N2  - Afrika hat seinen berechtigten Platz auf der Weltbühne noch nicht gefunden. Ein wichtiger Grund dafür besteht darin, dass afrikanische Regierungen – im Gegensatz zu denen Chinas, Indiens, Brasiliens oder Indonesiens – nicht jene Maßnahmen ergriffen haben, die für das Entstehen eines Mittelstandes aus dem Gemenge von Millionen Armen wichtig sind.
N2  - Africa has not attained its justifiable place on the world stage. One of the reasons for this is because unlike China, India, Brazil or Indonesia, Africa’s governments have not done what is necessary to permit a middle class to arise out of its teeming millions of poor.
KW  - Afrika
KW  - Wirtschaftspolitik
KW  - Africa
KW  - Economic Policy
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-46446
ER  - 
TY  - GEN
A1  - Püschel, Gerhard Paul
A1  - Hespeling, Ursula
A1  - Oppermann, Martin
A1  - Dieter, Peter
T1  - Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a
N2  - Human anaphylatoxin C3a increases glycogenolysis in perfused rat liver. This action is inhibited by prostanoid synthesis inhibitors and prostanoid antagonists. Because prostanoids but not anaphylatoxin C3a can increase glycogenolysis in hepatocytes, it has been proposed that prostanoid formation in nonparenchymal cells represents an important step in the C3a-dependent increase in hepatic glycogenolysis. This study shows that (a) human anaphylatoxin C3a (0.1 to 10 mug/ml) dose-dependently increased prostaglandin D2, thromboxane B, and prostaglandin F2alpha formation in rat liver macrophages (Kupffer cells); (b) the C3a-mediated increase in prostanoid formation was maximal after 2 min and showed tachyphylaxis; and (c) the C3a-elicited prostanoid formation could be inhibited specifically by preincubation of C3a with carboxypeptidase B to remove the essential C-terminal arginine or by preincubation of C3a with Fab fragments of a neutralizing monoclonal antibody. These data support the hypothesis that the C3a-dependent activation of hepatic glycogenolysis is mediated by way of a C3a-induced prostanoid production in Kupffer cells.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 037 
KW  - lactate output
KW  - glucose
KW  - complement
KW  - flow
KW  - prostaglandin-f2-alpha
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-16716
ER  - 
TY  - JOUR
A1  - Hocher, Berthold
A1  - Oberthür, Dominik
A1  - Slowinski, Torsten
A1  - Querfeld, Uwe
A1  - Schäfer, Franz
A1  - Doyon, Anke
A1  - Tepel, Martin
A1  - Roth, Heinz J.
A1  - Grön, Hans J.
A1  - Reichetzeder, Christoph
A1  - Betzel, Christian
A1  - Armbruster, Franz Paul
T1  - Modeling of Oxidized PTH (oxPTH) and Non-oxidized PTH (n-oxPTH) Receptor Binding and Relationship of Oxidized to Non-Oxidized PTH in Children with Chronic Renal Failure, Adult Patients on Hemodialysis and Kidney Transplant Recipients
JF  - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie
N2  - Background: The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s). However, PTH oxidation has been ignored during the development of PTH assays for clinical use so far. Even the nowadays used third generation assay systems do not consider oxidation of PTH. We recently developed an assay to differentiate between oxPTH and n-oxPTH. In the current study we established normal values for this assay system. Furthermore, we compare the ratio of oxPTH to n-oxPTH in different population with chronic renal failure: 620 children with renal failure stage 2-4 of the 4C study, 342 adult patients on dialysis, and 602 kidney transplant recipients. In addition, we performed modeling of the interaction of either oxPTH or n-oxPTH with the PTH receptor using biophysical structure approaches. Results: The children had the highest mean as well as maximum n-oxPTH concentrations as compared to adult patients (both patients on dialysis as well as kidney transplant recipients). The relationship between oxPTH and n-oxPTH of individual patients varied substantially in all three populations with renal impairment. The analysis of n-oxPTH in 89 healthy control subjects revealed that n-oxPTH concentrations in patient with renal failure were higher as compared to healthy adult controls (2.25-fold in children with renal failure, 1.53-fold in adult patients on dialysis, and 1.56-fold in kidney transplant recipients, respectively). Computer assisted biophysical structure modeling demonstrated, however, minor sterical- and/or electrostatic changes in oxPTH and n-oxPTH. This indicated that PTH oxidation may induce refolding of PTH and hence alters PTH-PTH receptor interaction via oxidation induced three-dimensional structure alteration of PTH. Conclusion: A huge proportion of circulating PTH measured by current state-of-the-art assay systems is oxidized and thus not biologically active. The relationship between oxPTH and n-oxPTH of individual patients varied substantially. Non-oxidized PTH concentrations are 1.5 - 2.25 fold higher in patients with renal failure as compared to health controls. Measurements of n-oxPTH may reflect the hormone status more precise. The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies.
KW  - n-oxPTH
KW  - Chronic Renal Failure
KW  - Kidney Transplantation
KW  - Hemodialysis
KW  - Oxidation
KW  - PTH
KW  - Chronic Renal Failure in Children
Y1  - 2013
U6  - https://doi.org/10.1159/000350149
SN  - 1420-4096
SN  - 1423-0143
VL  - 37
IS  - 4-5
SP  - 240
EP  - 251
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Voss, Björn
A1  - Bolhuis, Henk
A1  - Fewer, David P.
A1  - Kopf, Matthias
A1  - Möke, Fred
A1  - Haas, Fabian
A1  - El-Shehawy, Rehab
A1  - Hayes, Paul
A1  - Bergman, Birgitta
A1  - Sivonen, Kaarina
A1  - Dittmann-Thünemann, Elke
A1  - Scanlan, Dave J.
A1  - Hagemann, Martin
A1  - Stal, Lucas J.
A1  - Hess, Wolfgang R.
T1  - Insights into the physiology and ecology of the brackish-water-adapted cyanobacterium nodularia spumigena CCY9414 based on a genome-transcriptome analysis
JF  - PLoS one
N2  - Nodularia spumigena is a filamentous diazotrophic cyanobacterium that dominates the annual late summer cyanobacterial blooms in the Baltic Sea. But N. spumigena also is common in brackish water bodies worldwide, suggesting special adaptation allowing it to thrive at moderate salinities. A draft genome analysis of N. spumigena sp. CCY9414 yielded a single scaffold of 5,462,271 nucleotides in length on which genes for 5,294 proteins were annotated. A subsequent strand-specific transcriptome analysis identified more than 6,000 putative transcriptional start sites (TSS). Orphan TSSs located in intergenic regions led us to predict 764 non-coding RNAs, among them 70 copies of a possible retrotransposon and several potential RNA regulators, some of which are also present in other N2-fixing cyanobacteria. Approximately 4% of the total coding capacity is devoted to the production of secondary metabolites, among them the potent hepatotoxin nodularin, the linear spumigin and the cyclic nodulapeptin. The transcriptional complexity associated with genes involved in nitrogen fixation and heterocyst differentiation is considerably smaller compared to other Nostocales. In contrast, sophisticated systems exist for the uptake and assimilation of iron and phosphorus compounds, for the synthesis of compatible solutes, and for the formation of gas vesicles, required for the active control of buoyancy. Hence, the annotation and interpretation of this sequence provides a vast array of clues into the genomic underpinnings of the physiology of this cyanobacterium and indicates in particular a competitive edge of N. spumigena in nutrient-limited brackish water ecosystems.
Y1  - 2013
U6  - https://doi.org/10.1371/journal.pone.0060224
SN  - 1932-6203
VL  - 8
IS  - 3
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Tepel, Martin
A1  - Armbruster, Franz Paul
A1  - Groen, Hans Juergen
A1  - Scholze, Alexandra
A1  - Reichetzeder, Christoph
A1  - Roth, Heinz Jürgen
A1  - Hocher, Berthold
T1  - Nonoxidized, biologically active parathyroid hormone determines mortality in hemodialysis patients
JF  - The journal of clinical endocrinology & metabolism
N2  - Background: It was shown that nonoxidized PTH (n-oxPTH) is bioactive, whereas the oxidation of PTH results in a loss of biological activity.
 Methods: In this study we analyzed the association of n-oxPTH on mortality in hemodialysis patients using a recently developed assay system.
 Results: Hemodialysis patients (224 men, 116 women) had a median age of 66 years. One hundred seventy patients (50%) died during the follow-up period of 5 years. Median n-oxPTH levels were higher in survivors (7.2 ng/L) compared with deceased patients (5.0 ng/L; P = .002). Survival analysis showed an increased survival in the highest n-oxPTH tertile compared with the lowest n-oxPTH tertile (chi(2), 14.3; P = 0008). Median survival was 1702 days in the highest n-oxPTH tertile, whereas it was only 453 days in the lowest n-oxPTH tertile. Multivariable-adjusted Cox regression showed that higher age increased odds for death, whereas higher n-oxPTH reduced the odds for death. Another model analyzing a subgroup of patients with intact PTH (iPTH) concentrations at baseline above the upper normal range of the iPTH assay (70 ng/L) revealed that mortality in this subgroup was associated with oxidized PTH but not with n-oxPTH levels.
 Conclusions: The predictive power of n-oxPTH and iPTH on the mortality of hemodialysis patients differs substantially. Measurements of n-oxPTH may reflect the hormone status more precisely. The iPTH-associated mortality is most likely describing oxidative stress-related mortality.
Y1  - 2013
U6  - https://doi.org/10.1210/jc.2013-2139
SN  - 0021-972X
SN  - 1945-7197
VL  - 98
IS  - 12
SP  - 4744
EP  - 4751
PB  - Endocrine Society
CY  - Chevy Chase
ER  - 
TY  - CHAP
A1  - Hocher, Berthold
A1  - Armbruster, Franz Paul
A1  - Scholze, Alexandra
A1  - Marckmann, Peter
A1  - Reichetzeder, Christoph
A1  - Roth, Heinz Jürgen
A1  - Tepel, Martin
T1  - Non-oxidized, biological active parathyroid hormone determines motality in hemodialsysis patients
T2  - Nephrology, dialysis, transplantation
Y1  - 2013
SN  - 0931-0509
VL  - 28
SP  - 33
EP  - 33
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - GEN
A1  - Zurnic, Irena
A1  - Hütter, Sylvia
A1  - Rzeha, Ute
A1  - Stanke, Nicole
A1  - Reh, Juliane
A1  - Müllers, Erik
A1  - Hamann, Martin V.
A1  - Kern, Tobias
A1  - Gerresheim, Gesche K.
A1  - Lindel, Fabian
A1  - Serrao, Erik
A1  - Lesbats, Paul
A1  - Engelman, Alan N.
A1  - Cherepanov, Peter
A1  - Lindemann, Dirk
T1  - Interactions of prototype foamy virus capsids with host cell polo-like kinases are important for efficient viral DNA integration
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycle regulatory kinases, as a new interactor of PFV capsids. Further Y2H studies confirmed interaction of PFV Gag with several PLKs of both human and rat origin. A consensus Ser-Thr/Ser-Pro (S-T/S-P) motif in Gag, which is conserved among primate FVs and phosphorylated in PFV virions, was essential for recognition by PLKs. In the case of rat PLK2, functional kinase and polo-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK proteins to mitotic chromosomes in a Gag STP motif-dependent manner, confirming a specific and dominant nature of the Gag-PLK interaction in mammalian cells. The functional relevance of the Gag-PLK interaction was examined in the context of replication-competent FVs and single-round PFV vectors. Although STP motif mutated viruses displayed wild type (wt) particle release, RNA packaging and intra-particle reverse transcription, their replication capacity was decreased 3-fold in single-cycle infections, and up to 20-fold in spreading infections over an extended time period. Strikingly similar defects were observed when cells infected with single-round wt Gag PFV vectors were treated with a pan PLK inhibitor. Analysis of entry kinetics of the mutant viruses indicated a post-fusion defect resulting in delayed and reduced integration, which was accompanied with an enhanced preference to integrate into heterochromatin. We conclude that interaction between PFV Gag and cellular PLK proteins is important for early replication steps of PFV within host cells.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 580 
KW  - core protein
KW  - HIV-1 infection
KW  - retroviral integration
KW  - reverse transcription
KW  - nuclear-localization
KW  - box domain
KW  - in-vivo
KW  - Gag
KW  - PLK1
KW  - phosphorylation
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-411317
SN  - 1866-8372
IS  - 580
ER  - 
TY  - JOUR
A1  - Zurnic, Irena
A1  - Hütter, Sylvia
A1  - Rzeha, Ute
A1  - Stanke, Nicole
A1  - Reh, Juliane
A1  - Müllers, Erik
A1  - Hamann, Martin V.
A1  - Kern, Tobias
A1  - Gerresheim, Gesche K.
A1  - Lindel, Fabian
A1  - Serrao, Erik
A1  - Lesbats, Paul
A1  - Engelman, Alan N.
A1  - Cherepanov, Peter
A1  - Lindemann, Dirk
T1  - Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration
JF  - PLoS Pathogens
N2  - Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycle regulatory kinases, as a new interactor of PFV capsids. Further Y2H studies confirmed interaction of PFV Gag with several PLKs of both human and rat origin. A consensus Ser-Thr/Ser-Pro (S-T/S-P) motif in Gag, which is conserved among primate FVs and phosphorylated in PFV virions, was essential for recognition by PLKs. In the case of rat PLK2, functional kinase and polo-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK proteins to mitotic chromosomes in a Gag STP motif-dependent manner, confirming a specific and dominant nature of the Gag-PLK interaction in mammalian cells. The functional relevance of the Gag-PLK interaction was examined in the context of replication-competent FVs and single-round PFV vectors. Although STP motif mutated viruses displayed wild type (wt) particle release, RNA packaging and intra-particle reverse transcription, their replication capacity was decreased 3-fold in single-cycle infections, and up to 20-fold in spreading infections over an extended time period. Strikingly similar defects were observed when cells infected with single-round wt Gag PFV vectors were treated with a pan PLK inhibitor. Analysis of entry kinetics of the mutant viruses indicated a post-fusion defect resulting in delayed and reduced integration, which was accompanied with an enhanced preference to integrate into heterochromatin. We conclude that interaction between PFV Gag and cellular PLK proteins is important for early replication steps of PFV within host cells.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.ppat.1005860
SN  - 1553-7366
SN  - 1553-7374
VL  - 12
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - GEN
A1  - Hocher, Berthold
A1  - Oberthür, Dominik
A1  - Slowinski, Torsten
A1  - Querfeld, Uwe
A1  - Schaefer, Franz
A1  - Doyon, Anke
A1  - Tepel, Martin
A1  - Roth, Heinz J.
A1  - Grön, Hans J.
A1  - Reichetzeder, Christoph
A1  - Betzel, Christian
A1  - Armbruster, Franz Paul
T1  - Modeling of oxidized PTH (oxPTH) and non-oxidized PTH (n-oxPTH) receptor binding and relationship of oxidized to non-oxidized PTH in children with chronic renal failure, adult patients on hemodialysis and kidney transplant recipients
N2  - Background: The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s). However, PTH oxidation has been ignored during the development of PTH assays for clinical use so far. Even the nowadays used third generation assay systems do not consider oxidation of PTH. We recently developed an assay to differentiate between oxPTH and n-oxPTH. In the current study we established normal values for this assay system. Furthermore, we compare the ratio of oxPTH to n-oxPTH in different population with chronic renal failure: 620 children with renal failure stage 2-4 of the 4C study, 342 adult patients on dialysis, and 602 kidney transplant recipients. In addition, we performed modeling of the interaction of either oxPTH or n-oxPTH with the PTH receptor using biophysical structure approaches. Results: The children had the highest mean as well as maximum n-oxPTH concentrations as compared to adult patients (both patients on dialysis as well as kidney transplant recipients). The relationship between oxPTH and n-oxPTH of individual patients varied substantially in all three populations with renal impairment. The analysis of n-oxPTH in 89 healthy control subjects revealed that n-oxPTH concentrations in patient with renal failure were higher as compared to healthy adult controls (2.25-fold in children with renal failure, 1.53-fold in adult patients on dialysis, and 1.56-fold in kidney transplant recipients, respectively). Computer assisted biophysical structure modeling demonstrated, however, minor sterical- and/or electrostatic changes in oxPTH and n-oxPTH. This indicated that PTH oxidation may induce refolding of PTH and hence alters PTH-PTH receptor interaction via oxidation induced three-dimensional structure alteration of PTH. Conclusion: A huge proportion of circulating PTH measured by current state-of-the-art assay systems is oxidized and thus not biologically active. The relationship between oxPTH and n-oxPTH of individual patients varied substantially. Non-oxidized PTH concentrations are 1.5 - 2.25 fold higher in patients with renal failure as compared to health controls. Measurements of n-oxPTH may reflect the hormone status more precise. The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 343 
KW  - n-oxPTH
KW  - chronic renal failure
KW  - kidney transplantation
KW  - hemodialysis
KW  - oxidation
KW  - PTH
KW  - chronic renal failure in children
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-399980
ER  - 
TY  - JOUR
A1  - Renteria, Miguel E.
A1  - Schmaal, L.
A1  - Hibar, D. P.
A1  - Couvy-Duchesne, B.
A1  - Strike, L. T.
A1  - Mills, N. T.
A1  - de Zubicaray, Greig. I.
A1  - McMahon, Katie. L.
A1  - Medland, Sarah E.
A1  - Gillespie, N. A.
A1  - Hatton, S. N.
A1  - Lagopoulos, J.
A1  - Veltman, D. J.
A1  - van der Wee, N.
A1  - van Erp, T. G. M.
A1  - Wittfeld, K.
A1  - Grabe, H. J.
A1  - Block, Andrea
A1  - Hegenscheid, K.
A1  - Voelzke, H.
A1  - Veer, I. M.
A1  - Walter, H.
A1  - Schnell, K.
A1  - Schramm, E.
A1  - Normann, C.
A1  - Schoepf, Dieter
A1  - Konrad, C.
A1  - Zurowski, B.
A1  - Godlewska, B. R.
A1  - Cowen, P. J.
A1  - Penninx, B. W. J. H.
A1  - Jahanshad, N.
A1  - Thompson, Paul M.
A1  - Wright, M. J.
A1  - Martin, N. G.
A1  - Christensen, H.
A1  - Hickie, I. B.
T1  - Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
JF  - Translational Psychiatry
Y1  - 2017
U6  - https://doi.org/10.1038/tp.2017.84
SN  - 2158-3188
VL  - 7
SP  - 2301
EP  - 2320
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Vasyura-Bathke, Hannes
A1  - Dettmer, Jan
A1  - Dutta, Rishabh
A1  - Mai, Paul Martin
A1  - Jónsson, Sigurjón
T1  - Accounting for theory errors with empirical Bayesian noise models in nonlinear centroid moment tensor estimation
JF  - Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society
N2  - Centroid moment tensor (CMT) parameters can be estimated from seismic waveforms. Since these data indirectly observe the deformation process, CMTs are inferred as solutions to inverse problems which are generally underdetermined and require significant assumptions, including assumptions about data noise. Broadly speaking, we consider noise to include both theory and measurement errors, where theory errors are due to assumptions in the inverse problem and measurement errors are caused by the measurement process. While data errors are routinely included in parameter estimation for full CMTs, less attention has been paid to theory errors related to velocity-model uncertainties and how these affect the resulting moment-tensor (MT) uncertainties. Therefore, rigorous uncertainty quantification for CMTs may require theory-error estimation which becomes a problem of specifying noise models. Various noise models have been proposed, and these rely on several assumptions. All approaches quantify theory errors by estimating the covariance matrix of data residuals. However, this estimation can be based on explicit modelling, empirical estimation and/or ignore or include covariances. We quantitatively compare several approaches by presenting parameter and uncertainty estimates in nonlinear full CMT estimation for several simulated data sets and regional field data of the M-1 4.4, 2015 June 13 Fox Creek, Canada, event. While our main focus is at regional distances, the tested approaches are general and implemented for arbitrary source model choice. These include known or unknown centroid locations, full MTs, deviatoric MTs and double-couple MTs. We demonstrate that velocity-model uncertainties can profoundly affect parameter estimation and that their inclusion leads to more realistic parameter uncertainty quantification. However, not all approaches perform equally well. Including theory errors by estimating non-stationary (non-Toeplitz) error covariance matrices via iterative schemes during Monte Carlo sampling performs best and is computationally most efficient. In general, including velocity-model uncertainties is most important in cases where velocity structure is poorly known.
KW  - Inverse theory
KW  - Probability distributions
KW  - Waveform inversion
KW  - Earthquake source observations
KW  - Seismic noise
Y1  - 2021
U6  - https://doi.org/10.1093/gji/ggab034
SN  - 0956-540X
SN  - 1365-246X
VL  - 225
IS  - 2
SP  - 1412
EP  - 1431
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - BOOK
A1  - Fuhrmann, Michaela
A1  - Schubarth, Wilfried
A1  - Schulze-Reichelt, Friederike
A1  - Mauermeister, Sylvi
A1  - Seidel, Andreas
A1  - Hartmann, Nina
A1  - Erdmann, Melinda
A1  - Apostolow, Benjamin
A1  - Wagner, Laura
A1  - Berndt, Sarah
A1  - Wippermann, Melanie
A1  - Ratzlaff, Olaf
A1  - Lumpe, Matthias
A1  - Kirjuchina, Ljuba
A1  - Rost, Sophia
A1  - Zurek, Peter Paul
A1  - Faaß, Marcel
A1  - Schellhorn, Sebastian
A1  - Frank, Mario
A1  - Kreitz, Christoph
A1  - Wagner, Nelli
A1  - Jenneck, Julia
A1  - Kleemann, Katrin
A1  - Vock, Miriam
A1  - Schröder, Christian
A1  - Erdmann, Kathrin
A1  - Koziol, Matthias
A1  - Meißner, Marlen
A1  - Dibiasi, Anna
A1  - Unger, Martin
A1  - Piskunova, Elena V.
A1  - Bahmutskiy, Andrey E.
A1  - Bessonova, Ekatarina A.
A1  - Borovik, Ludmila K.
ED  - Schubarth, Wilfried
ED  - Mauermeister, Sylvi
ED  - Schulze-Reichelt, Friederike
ED  - Seidel, Andreas
T1  - Alles auf Anfang!
BT  - Befunde und Perspektiven zum Studieneingang
T3  - Potsdamer Beiträge zur Hochschulforschung
N2  - Im Zuge der Bologna-Reform ist an Hochschulen vieles in Bewegung gekommen. Studium und Lehre sind stärker ins Blickfeld gerückt. Dabei kommt der Studieneingangsphase besondere Bedeutung zu, werden doch hier die Weichen für ein erfolgreiches Studium gestellt. Deshalb ist es verständlich, dass die Hauptanstrengungen der Hochschulen auf den Studieneingang gerichtet sind – ganz nach dem Motto: „Auf den Anfang kommt es an!“. Konsens herrscht dahingehend, dass der Studieneingang neu zu gestalten ist, doch beim „Wie?“ gibt es unterschiedliche Antworten. Zugleich wird immer deutlicher, dass eine wirksame Neugestaltung der Eingangsphase nur mit einer umfassenden Reform des Studiums gelingen kann.
Ziel des vierten Bandes der Potsdamer Beiträge zur Hochschulforschung ist es, eine Zwischenbilanz der Debatte zum Studieneingang zu ziehen. Auf der Basis empirischer Studien werden unterschiedliche Perspektiven auf den Studieneingang eingenommen und Empfehlungen zur Optimierung des Studieneingangs abgeleitet. Die zahlreichen Untersuchungsergebnisse Potsdamer Forschergruppen werden durch weitere nationale sowie internationale Perspektiven ergänzt. Der Band richtet sich an alle, die sich für die Entwicklung an Hochschulen interessieren.
T3  - Potsdamer Beiträge zur Hochschulforschung - 4 
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-422965
SN  - 978-3-86956-452-4
SN  - 2192-1075
SN  - 2192-1083
IS  - 4
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - van Marle, Allard Jan
A1  - Bohdan, Artem
A1  - Morris, Paul J.
A1  - Pohl, Martin
A1  - Marcowith, Alexandre
T1  - Diffusive shock acceleration at oblique high mach number shocks
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - The current paradigm of cosmic-ray (CR) origin states that the greater part of galactic CRs is produced by supernova remnants. The interaction of supernova ejecta with the interstellar medium after a supernova's explosions results in shocks responsible for CR acceleration via diffusive shock acceleration (DSA). We use particle-in-cell (PIC) simulations and a combined PIC-magnetohydrodynamic (PIC-MHD) technique to investigate whether DSA can occur in oblique high Mach number shocks. Using the PIC method, we follow the formation of the shock and determine the fraction of the particles that gets involved in DSA. With this result, we use PIC-MHD simulations to model the large-scale structure of the plasma and the magnetic field surrounding the shock and find out whether or not the reflected particles can generate upstream turbulence and trigger DSA. We find that the feasibility of this process in oblique shocks depends strongly on the Alfvenic Mach number, and the DSA process is more likely to be triggered at high Mach number shocks.
Y1  - 2022
U6  - https://doi.org/10.3847/1538-4357/ac5962
SN  - 1538-4357
VL  - 929
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Schattan, Paul
A1  - Köhli, Markus
A1  - Schrön, Martin
A1  - Baroni, Gabriele
A1  - Oswald, Sascha
T1  - Sensing area-average snow water equivalent with cosmic-ray neutrons: the influence of fractional snow cover
JF  - Water resources research
N2  - Cosmic-ray neutron sensing (CRNS) is a promising non-invasive technique to estimate snow water equivalent (SWE) over large areas. In contrast to preliminary studies focusing on shallow snow conditions (SWE <130 mm), more recently the method was shown experimentally to be sensitive also to deeper snowpacks providing the basis for its use at mountain experimental sites. However, hysteretic neutron response has been observed for complex snow cover including patchy snow-free areas. In the present study we aimed to understand and support the experimental findings using a comprehensive neutron modeling approach. Several simulations have been set up in order to disentangle the effect on the signal of different land surface characteristics and to reproduce multiple observations during periods of snow melt and accumulation. To represent the actual land surface heterogeneity and the complex snow cover, the model used data from terrestrial laser scanning. The results show that the model was able to accurately reproduce the CRNS signal and particularly the hysteresis effect during accumulation and melting periods. Moreover, the sensor footprint was found to be anisotropic and affected by the spatial distribution of liquid water and snow as well as by the topography of the nearby mountains. Under fully snow-covered conditions the CRNS is able to accurately estimate SWE without prior knowledge about snow density profiles or other spatial anomalies. These results provide new insights into the characteristics of the detected neutron signal in complex terrain and support the use of CRNS for long-term snow monitoring in high elevated mountain environments.
KW  - area-average snow monitoring
KW  - cosmic-ray neutron sensing
KW  - neutron simulations
KW  - spatial heterogeneity
KW  - fractional snow cover
Y1  - 2019
U6  - https://doi.org/10.1029/2019WR025647
SN  - 0043-1397
SN  - 1944-7973
VL  - 55
IS  - 12
SP  - 10796
EP  - 10812
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Gossner, Martin M.
A1  - Lewinsohn, Thomas M.
A1  - Kahl, Tiemo
A1  - Grassein, Fabrice
A1  - Boch, Steffen
A1  - Prati, Daniel
A1  - Birkhofer, Klaus
A1  - Renner, Swen C.
A1  - Sikorski, Johannes
A1  - Wubet, Tesfaye
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Jorge, Leonardo Re
A1  - Jung, Kirsten
A1  - Keyel, Alexander C.
A1  - Klein, Alexandra-Maria
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Müller, Jörg
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Penone, Caterina
A1  - Perovic, David J.
A1  - Purschke, Oliver
A1  - Schall, Peter
A1  - Socher, Stephanie A.
A1  - Sonnemann, Ilja
A1  - Tschapka, Marco
A1  - Tscharntke, Teja
A1  - Türke, Manfred
A1  - Venter, Paul Christiaan
A1  - Weiner, Christiane N.
A1  - Werner, Michael
A1  - Wolters, Volkmar
A1  - Wurst, Susanne
A1  - Westphal, Catrin
A1  - Fischer, Markus
A1  - Weisser, Wolfgang W.
A1  - Allan, Eric
T1  - Land-use intensification causes multitrophic homogenization of grassland communities
JF  - Nature : the international weekly journal of science
N2  - Land-use intensification is a major driver of biodiversity loss(1,2). Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in beta-diversity (the compositional dissimilarity between sites). Most studies have investigated losses in local (alpha)-diversity(1,3) and neglected biodiversity loss at larger spatial scales. Studies addressing beta-diversity have focused on single or a few organism groups (for example, ref. 4), and it is thus unknown whether land-use intensification homogenizes communities at different trophic levels, above-and belowground. Here we show that even moderate increases in local land-use intensity (LUI) cause biotic homogenization across microbial, plant and animal groups, both above- and belowground, and that this is largely independent of changes in alpha-diversity. We analysed a unique grassland biodiversity dataset, with abundances of more than 4,000 species belonging to 12 trophic groups. LUI, and, in particular, high mowing intensity, had consistent effects on beta-diversity across groups, causing a homogenization of soil microbial, fungal pathogen, plant and arthropod communities. These effects were nonlinear and the strongest declines in beta-diversity occurred in the transition from extensively managed to intermediate intensity grassland. LUI tended to reduce local alpha-diversity in aboveground groups, whereas the alpha-diversity increased in belowground groups. Correlations between the alpha-diversity of different groups, particularly between plants and their consumers, became weaker at high LUI. This suggests a loss of specialist species and is further evidence for biotic homogenization. The consistently negative effects of LUI on landscape-scale biodiversity underscore the high value of extensively managed grasslands for conserving multitrophic biodiversity and ecosystem service provision. Indeed, biotic homogenization rather than local diversity loss could prove to be the most substantial consequence of land-use intensification.
Y1  - 2016
U6  - https://doi.org/10.1038/nature20575
SN  - 0028-0836
SN  - 1476-4687
VL  - 540
SP  - 266
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Wittig, Alice
A1  - Miranda, Fabio Malcher
A1  - Hölzer, Martin
A1  - Altenburg, Tom
A1  - Bartoszewicz, Jakub Maciej
A1  - Beyvers, Sebastian
A1  - Dieckmann, Marius Alfred
A1  - Genske, Ulrich
A1  - Giese, Sven Hans-Joachim
A1  - Nowicka, Melania
A1  - Richard, Hugues
A1  - Schiebenhoefer, Henning
A1  - Schmachtenberg, Anna-Juliane
A1  - Sieben, Paul
A1  - Tang, Ming
A1  - Tembrockhaus, Julius
A1  - Renard, Bernhard Y.
A1  - Fuchs, Stephan
T1  - CovRadar
BT  - continuously tracking and filtering SARS-CoV-2 mutations for genomic surveillance
JF  - Bioinformatics
N2  - The ongoing pandemic caused by SARS-CoV-2 emphasizes the importance of genomic surveillance to understand the evolution of the virus, to monitor the viral population, and plan epidemiological responses. Detailed analysis, easy visualization and intuitive filtering of the latest viral sequences are powerful for this purpose. We present CovRadar, a tool for genomic surveillance of the SARS-CoV-2 Spike protein. CovRadar consists of an analytical pipeline and a web application that enable the analysis and visualization of hundreds of thousand sequences. First, CovRadar extracts the regions of interest using local alignment, then builds a multiple sequence alignment, infers variants and consensus and finally presents the results in an interactive app, making accessing and reporting simple, flexible and fast.
Y1  - 2022
U6  - https://doi.org/10.1093/bioinformatics/btac411
SN  - 1367-4803
SN  - 1367-4811
VL  - 38
IS  - 17
SP  - 4223
EP  - 4225
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Schrön, Martin
A1  - Zacharias, Steffen
A1  - Womack, Gary
A1  - Köhli, Markus
A1  - Desilets, Darin
A1  - Oswald, Sascha
A1  - Bumberger, Jan
A1  - Mollenhauer, Hannes
A1  - Kögler, Simon
A1  - Remmler, Paul
A1  - Kasner, Mandy
A1  - Denk, Astrid
A1  - Dietrich, Peter
T1  - Intercomparison of cosmic-ray neutron sensors and water balance monitoring in an urban environment
JF  - Geoscientific instrumentation, methods and data systems
N2  - Sensor-to-sensor variability is a source of error common to all geoscientific instruments that needs to be assessed before comparative and applied research can be performed with multiple sensors. Consistency among sensor systems is especially critical when subtle features of the surrounding terrain are to be identified. Cosmic-ray neutron sensors (CRNSs) are a recent technology used to monitor hectometre-scale environmental water storages, for which a rigorous comparison study of numerous co-located sensors has not yet been performed. In this work, nine stationary CRNS probes of type "CRS1000" were installed in relative proximity on a grass patch surrounded by trees, buildings, and sealed areas. While the dynamics of the neutron count rates were found to be similar, offsets of a few percent from the absolute average neutron count rates were found. Technical adjustments of the individual detection parameters brought all instruments into good agreement. Furthermore, we found a critical integration time of 6 h above which all sensors showed consistent dynamics in the data and their RMSE fell below 1% of gravimetric water content. The residual differences between the nine signals indicated local effects of the complex urban terrain on the scale of several metres. Mobile CRNS measurements and spatial simulations with the URANOS neutron transport code in the surrounding area (25 ha) have revealed substantial sub-footprint heterogeneity to which CRNS detectors are sensitive despite their large averaging volume. The sealed and constantly dry structures in the footprint furthermore damped the dynamics of the CRNS-derived soil moisture. We developed strategies to correct for the sealed-area effect based on theoretical insights about the spatial sensitivity of the sensor. This procedure not only led to reliable soil moisture estimation during dry-out periods, it further revealed a strong signal of intercepted water that emerged over the sealed surfaces during rain events. The presented arrangement offered a unique opportunity to demonstrate the CRNS performance in complex terrain, and the results indicated great potential for further applications in urban climate research.
Y1  - 2018
U6  - https://doi.org/10.5194/gi-7-83-2018
SN  - 2193-0856
SN  - 2193-0864
VL  - 7
IS  - 1
SP  - 83
EP  - 99
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Sandberg, Oskar J.
A1  - Kurpiers, Jona
A1  - Stolterfoht, Martin
A1  - Neher, Dieter
A1  - Meredith, Paul
A1  - Shoaee, Safa
A1  - Armin, Ardalan
T1  - On the question of the need for a built-in potential in Perovskite solar cells
JF  - Advanced materials interfaces
N2  - Perovskite semiconductors as the active materials in efficient solar cells exhibit free carrier diffusion lengths on the order of microns at low illumination fluxes and many hundreds of nanometers under 1 sun conditions. These lengthscales are significantly larger than typical junction thicknesses, and thus the carrier transport and charge collection should be expected to be diffusion controlled. A consensus along these lines is emerging in the field. However, the question as to whether the built-in potential plays any role is still of matter of some conjecture. This important question using phase-sensitive photocurrent measurements and theoretical device simulations based upon the drift-diffusion framework is addressed. In particular, the role of the built-in electric field and charge-selective transport layers in state-of-the-art p-i-n perovskite solar cells comparing experimental findings and simulation predictions is probed. It is found that while charge collection in the junction does not require a drift field per se, a built-in potential is still needed to avoid the formation of reverse electric fields inside the active layer, and to ensure efficient extraction through the charge transport layers.
KW  - built-in potential
KW  - charge collection
KW  - charge transport layers
KW  - perovskite solar cells
Y1  - 2020
U6  - https://doi.org/10.1002/admi.202000041
SN  - 2196-7350
VL  - 7
IS  - 10
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Jiang, Wei
A1  - Tao, Chen
A1  - Stolterfoht, Martin
A1  - Jin, Hui
A1  - Stephen, Meera
A1  - Lin, Qianqian
A1  - Nagiri, Ravi C. R.
A1  - Burn, Paul L.
A1  - Gentle, Ian R.
T1  - Hole-transporting materials for low donor content organic solar cells
BT  - charge transport and device performance
JF  - Organic electronics : physics, materials and applications
N2  - Low donor content solar cells are an intriguing class of photovoltaic device about which there is still considerable discussion with respect to their mode of operation. We have synthesized a series of triphenylamine-based materials for use in low donor content devices with the electron accepting [6,6]-phenyl-C71-butyric acid methyl ester (PC(7)0BM). The triphenylamine-based materials absorb light in the near UV enabling the PC(7)0BM to be be the main light absorbing organic semiconducting material in the solar cell. It was found that the devices did not operate as classical Schottky junctions but rather photocurrent was generated by hole transfer from the photo-excited PC(7)0BM to the triphenylamine-based donors. We found that replacing the methoxy surface groups with methyl groups on the donor material led to a decrease in hole mobility for the neat films, which was due to the methyl substituted materials having the propensity to aggregate. The thermodynamic drive to aggregate was advantageous for the performance of the low donor content (6 wt%) films. It was found that the 6 wt% donor devices generally gave higher performance than devices containing 50 wt% of the donor.
KW  - photoexcited hole transfer
KW  - photocurrent generation
KW  - synthesis
KW  - hole
KW  - mobility
KW  - low donor content
KW  - Schottky junction
Y1  - 2020
U6  - https://doi.org/10.1016/j.orgel.2019.105480
SN  - 1566-1199
SN  - 1878-5530
VL  - 76
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jiang, Wei
A1  - Stolterfoht, Martin
A1  - Jin, Hui
A1  - Burn, Paul L.
T1  - Hole-transporting poly(dendrimer)s as electron donors for low donor organic solar cells with efficient charge transport
JF  - Macromolecules : a publication of the American Chemical Society
N2  - Recent work on bulk-heterojunction organic solar cells has shown that photoexcitation of the electron acceptor followed by photoinduced hole transfer can play a significant role in photocurrent generation. To establish a clear understanding of the role of the donor in the photoinduced hole transfer process, we have synthesized a series of triphenylamine-based hole-transporting poly(dendrimer)s with mechanically flexible nonconjugated backbones via ring-opening metathesis polymerization and used them in low donor content solar cells. The poly(dendrimer)s were found to retain the hole transporting properties of the parent dendrimer, with hole mobilities of similar to 10(-3) cm(2)/(V s) for solution processed neat films. However, when blended with [6,6]-phenyl-C-70-butyric acid methyl ester (PC70BM), the best performing poly(dendrimer) was found to form films that had balanced and relatively high hole/electron mobilities of similar to 5 x 10(-4) cm(2) /(V s). In contrast, at the same concentration the parent dendrimer:PC70BM blend was found to have a hole mobility of 4 orders of magnitude less than the electron mobility. The balanced hole and electron mobilities for the 6 wt % poly(dendrimer):PC70BM blend led to an absence of second-order bimolecular recombination losses at the maximum power point and resulted in a fill factor of 0.65 and a PCE 2.1% for the devices, which was almost three times higher than the cells composed of the parent dendrimer:PC70BM blends.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.macromol.0c00520
SN  - 0024-9297
SN  - 1520-5835
VL  - 53
IS  - 8
SP  - 2902
EP  - 2911
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Zeiske, Stefan
A1  - Sandberg, Oskar J.
A1  - Zarrabi, Nasim
A1  - Wolff, Christian Michael
A1  - Raoufi, Meysam
A1  - Peña-Camargo, Francisco
A1  - Gutierrez-Partida, Emilio
A1  - Meredith, Paul
A1  - Stolterfoht, Martin
A1  - Armin, Ardalan
T1  - Static disorder in lead halide perovskites
JF  - The journal of physical chemistry letters
N2  - In crystalline and amorphous semiconductors, the temperature-dependent Urbach energy can be determined from the inverse slope of the logarithm of the absorption spectrum and reflects the static and dynamic energetic disorder. Using recent advances in the sensitivity of photocurrent spectroscopy methods, we elucidate the temperature-dependent Urbach energy in lead halide perovskites containing different numbers of cation components. We find Urbach energies at room temperature to be 13.0 +/- 1.0, 13.2 +/- 1.0, and 13.5 +/- 1.0 meV for single, double, and triple cation perovskite. Static, temperature-independent contributions to the Urbach energy are found to be as low as 5.1 ?+/- 0.5, 4.7 +/- 0.3, and 3.3 +/- 0.9 meV for the same systems. Our results suggest that, at a low temperature, the dominant static disorder in perovskites is derived from zero-point phonon energy rather than structural disorder. This is unusual for solution-processed semiconductors but broadens the potential application of perovskites further to quantum electronics and devices.
KW  - Cations
KW  - External quantum efficiency
KW  - Perovskites
KW  - Solar cells
KW  - Solar energy
Y1  - 2022
U6  - https://doi.org/10.1021/acs.jpclett.2c01652
SN  - 1948-7185
VL  - 13
IS  - 31
SP  - 7280
EP  - 7285
PB  - American Chemical Society
CY  - Washington
ER  -