TY  - GEN
A1  - McQuade, D. Tyler
A1  - O'Brien, Alexander G.
A1  - Dörr, Markus
A1  - Rajaratnam, Rajathees
A1  - Eisold, Ursula
A1  - Monnanda, Bopanna
A1  - Nobuta, Tomoya
A1  - Löhmannsröben, Hans-Gerd
A1  - Meggers, Eric
A1  - Seeberger, Peter H.
T1  - Continuous synthesis of pyridocarbazoles and initial photophysical and bioprobe characterization
N2  - Pyridocarbazoles when ligated to transition metals yield high affinity kinase inhibitors. While batch photocyclizations enable the synthesis of these heterocycles, the non-oxidative Mallory reaction only provides modest yields and difficult to purify mixtures. We demonstrate here that a flow-based Mallory cyclization provides superior results and enables observation of a clear isobestic point. The flow method allowed us to rapidly synthesize ten pyridocarbazoles and for the first time to document their interesting photophysical attributes. Preliminary characterization reveals that these molecules might be a new class of fluorescent bioprobe.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 246 
KW  - protein-kinase inhibitors
KW  - continuous-flow
KW  - photochemical synthesis
KW  - light
KW  - efficient
KW  - phenanthrenes
KW  - complexes
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95214
SP  - 4067
EP  - 4070
ER  -