TY  - JOUR
A1  - Christopher Ashwood, Wout Bittremieux
A1  - Bittremieux, Wout
A1  - Deutsch, Eric W.
A1  - Doncheva, Nadezhda T.
A1  - Dorfer, Viktoria
A1  - Gabriels, Ralf
A1  - Gorshkov, Vladimir
A1  - Gupta, Surya
A1  - Jones, Andrew R.
A1  - Käll, Lukas
A1  - Kopczynski, Dominik
A1  - Lane, Lydie
A1  - Lautenbacher, Ludwig
A1  - Legeay, Marc
A1  - Locard-Paulet, Marie
A1  - Mesuere, Bart
A1  - Sachsenberg, Timo
A1  - Salz, Renee
A1  - Samaras, Patroklos
A1  - Schiebenhoefer, Henning
A1  - Schmidt, Tobias
A1  - Schwämmle, Veit
A1  - Soggiu, Alessio
A1  - Uszkoreit, Julian
A1  - Van Den Bossche, Tim
A1  - Van Puyvelde, Bart
A1  - Van Strien, Joeri
A1  - Verschaffelt, Pieter
A1  - Webel, Henry
A1  - Willems, Sander
A1  - Perez-Riverolab, Yasset
A1  - Netz, Eugen
A1  - Pfeuffer, Julianus
T1  - Proceedings of the EuBIC-MS 2020 Developers’ Meeting
JF  - EuPA Open Proteomics
N2  - The 2020 European Bioinformatics Community for Mass Spectrometry (EuBIC-MS) Developers’ meeting was held from January 13th to January 17th 2020 in Nyborg, Denmark. Among the participants were scientists as well as developers working in the field of computational mass spectrometry (MS) and proteomics. The 4-day program was split between introductory keynote lectures and parallel hackathon sessions. During the latter, the participants developed bioinformatics tools and resources addressing outstanding needs in the community. The hackathons allowed less experienced participants to learn from more advanced computational MS experts, and to actively contribute to highly relevant research projects. We successfully produced several new tools that will be useful to the proteomics community by improving data analysis as well as facilitating future research. All keynote recordings are available on https://doi.org/10.5281/zenodo.3890181.
KW  - computational mass spectrometry
KW  - proteomics
KW  - bioinformatics
KW  - spectrum clustering
KW  - phosphoproteomics
KW  - XIC extraction
KW  - proteomics graph networks
KW  - predicted spectra
Y1  - 2020
U6  - https://doi.org/10.1016/j.euprot.2020.11.001
SN  - 2212-9685
VL  - 24
SP  - 1
EP  - 6
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - GEN
A1  - Schmidt, Katja
A1  - Walz, Ariane
A1  - Jones, Isobel
A1  - Metzger, Marc J.
T1  - The sociocultural value of upland regions in the vicinity of cities in comparison with urban green spaces
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Mountain and upland regions provide a wide range of ecosystem services to residents and visitors. While ecosystem research in mountain regions is on the rise, the linkages between sociocultural benefits and ecological systems remain little explored. Mountainous regions close to urban areas provide numerous benefits to a large number of individuals, suggesting a high social value, particularly for cultural ecosystem services. We explored and compared visitors' valuation of ecosystem services in the Pentland Hills, an upland range close to the city of Edinburgh, Scotland, and urban green spaces within Edinburgh. Based on 715 responses to user surveys in both study areas, we identified intense use and high social value for both areas. Several ecosystem services were perceived as equally important in both areas, including many cultural ecosystem services. Significant differences were revealed in the value of physically using nature, which Pentland Hills users rated more highly than those in the urban green spaces, and of mitigation of pollutants and carbon sequestration, for which the urban green spaces were valued more highly. Major differences were further identified for preferences in future land management, with nature-oriented management preferred by about 57% of the interviewees in the Pentland Hills, compared to 31% in the urban parks. The study highlights the substantial value of upland areas in close vicinity to a city for physically using and experiencing nature, with a strong acceptance of nature conservation.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 920 
KW  - ecosystem services
KW  - mountains near cities
KW  - urban green spaces
KW  - social valuation
KW  - perception
KW  - preferences in land management
KW  - Scotland
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442010
SN  - 1866-8372
IS  - 920
SP  - 465
EP  - 474
ER  - 
TY  - JOUR
A1  - Schmidt, Christian
A1  - Behl, Marc
A1  - Lendlein, Andreas
A1  - Beuermann, Sabine
T1  - Synthesis of high molecular weight polyglycolide in supercritical carbon dioxide
JF  - RSC Advances
N2  - Polyglycolide (PGA) is a biodegradable polymer with multiple applications in the medical sector. Here the synthesis of high molecular weight polyglycolide by ring-opening polymerization of diglycolide is reported. For the first time stabilizer free supercritical carbon dioxide (scCO(2)) was used as a reaction medium. scCO(2) allowed for a reduction in reaction temperature compared to conventional processes. Together with the lowering of monomer concentration and consequently reduced heat generation compared to bulk reactions thermal decomposition of the product occurring already during polymerization is strongly reduced. The reaction temperatures and pressures were varied between 120 and 150 degrees C and 145 to 1400 bar. Tin(II) ethyl hexanoate and 1-dodecanol were used as catalyst and initiator, respectively. The highest number average molecular weight of 31 200 g mol(-1) was obtained in 5 hours from polymerization at 120 degrees C and 530 bar. In all cases the products were obtained as a dry white powder. Remarkably, independent of molecular weight the melting temperatures were always at (219 +/- 2)degrees C.
Y1  - 2014
U6  - https://doi.org/10.1039/c4ra06815g
SN  - 2046-2069
VL  - 4
IS  - 66
SP  - 35099
EP  - 35105
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Schmidt, Christian
A1  - Behl, Marc
A1  - Lendlein, Andreas
A1  - Bauermann, Sabine
T1  - Synthesis of high molecular weight polyglycolide in supercritical carbon dioxide
N2  - Polyglycolide (PGA) is a biodegradable polymer with multiple applications in the medical sector. Here the synthesis of high molecular weight polyglycolide by ring-opening polymerization of diglycolide is reported. For the first time stabilizer free supercritical carbon dioxide (scCO2) was used as a reaction medium. scCO2 allowed for a reduction in reaction temperature compared to conventional processes. Together with the lowering of monomer concentration and consequently reduced heat generation compared to bulk reactions thermal decomposition of the product occurring already during polymerization is strongly reduced. The reaction temperatures and pressures were varied between 120 and 150 °C and 145 to 1400 bar. Tin(II) ethyl hexanoate and 1-dodecanol were used as catalyst and initiator, respectively. The highest number average molecular weight of 31 200 g mol−1 was obtained in 5 hours from polymerization at 120 °C and 530 bar. In all cases the products were obtained as a dry white powder. Remarkably, independent of molecular weight the melting temperatures were always at (219 ± 2) °C.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 284 
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-99439
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Song, Hui
A1  - Bergstrasser, Claudia
A1  - Rafat, Neysan
A1  - Hoeger, Simone
A1  - Schmidt, Marc
A1  - Endres, N.
A1  - Goebeler, Matthias
A1  - Hillebrands, Jan-Luuk
A1  - Brigelius-Flohé, Regina
A1  - Banning, Antje
A1  - Beck, Grietje
A1  - Loesel, Ralf
A1  - Yard, Benito A.
T1  - The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E- selectin independently of haem oxygenase-1 expression
N2  - Background and purpose: Although carbon monoxide (CO) can modulate inflammatory processes, the influence of CO on adhesion molecules is less clear. This might be due to the limited amount of CO generated by haem degradation. We therefore tested the ability of a CO releasing molecule (CORM-3), used in supra-physiological concentrations, to modulate the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin on endothelial cells and the mechanism(s) involved. Experimental approach: Human umbilical vein endothelial cells (HUVECs) were stimulated with tumour necrosis factor (TNF)-alpha in the presence or absence of CORM-3. The influence of CORM-3 on VCAM-1 and E- selectin expression and the nuclear factor (NF)-kappa B pathway was assessed by flow cytometry, Western blotting and electrophoretic mobility shift assay. Key results: CORM-3 inhibited the expression of VCAM-1 and E-selectin on TNF-alpha- stimulated HUVEC. VCAM-1 expression was also inhibited when CORM-3 was added 24 h after TNF-alpha stimulation or when TNF-alpha was removed. This was paralleled by deactivation of NF-kappa B and a reduction in VCAM-1 mRNA. Although TNF- alpha removal was more effective in this regard, VCAM-1 protein was down-regulated more rapidly when CORM-3 was added. CORM-3 induced haem oxygenase-1 (HO-1) in a dose- and time-dependent manner, mediated by the transcription factor, Nrf2. CORM-3 was still able to down-regulate VCAM-1 expression in HUVEC transfected with siRNA for HO-1 or Nrf2. Conclusions and implications: Down-regulation of VCAM and E-selectin expression induced by CORM-3 was independent of HO-1 up- regulation and was predominantly due to inhibition of sustained NF-kappa B activation.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/journal/121548564/home
U6  - https://doi.org/10.1111/j.1476-5381.2009.00215.x
SN  - 0007-1188
ER  - 
TY  - JOUR
A1  - Schmidt, Katja
A1  - Walz, Ariane
A1  - Jones, Isobel
A1  - Metzger, Marc J.
T1  - The Sociocultural Value of Upland Regions in the Vicinity of Cities in Comparison With Urban Green Spaces
JF  - Mountain research and development
KW  - Ecosystem services
KW  - mountains near cities
KW  - urban green spaces
KW  - social valuation
KW  - perception
KW  - preferences in land management
KW  - Scotland
Y1  - 2016
U6  - https://doi.org/10.1659/MRD-JOURNAL-D-16-00044.1
SN  - 0276-4741
SN  - 1994-7151
VL  - 36
SP  - 465
EP  - 474
PB  - American Geophysical Union
CY  - Lawrence
ER  - 
TY  - JOUR
A1  - Lilliestam, Johan
A1  - Melliger, Marc André
A1  - Ollier, Lana
A1  - Schmidt, Tobias S.
A1  - Steffen, Bjarne
T1  - Understanding and accounting for the effect of exchange rate fluctuations on global learning rates
JF  - Nature energy
N2  - Learning rates are a central concept in energy system models and integrated assessment models, as they allow researchers to project the future costs of new technologies and to optimize energy system costs. Here we argue that exchange rate fluctuations are an important, but thus far overlooked, determinant of the learning-rate variance observed in the literature. We explore how empirically observed global learning rates depend on where technologies are installed and which currency is used to calculate the learning rate. Using global data of large-scale photovoltaic (>= 5 MW) plants, we show that the currency choice can result in learning-rate differences of up to 16 percentage points. We then introduce an adjustment factor to correct for the effect of exchange rate and market focus fluctuations and discuss the implications of our findings for innovation scholars, energy modellers and decision makers. <br /> Learning rates are a measure of reduction in costs of energy from technologies such as solar photovoltaics. These are often estimated internationally with all monetary figures converted to a single currency, often US dollars. Lilliestam et al. show that such conversions can significantly affect the learning rate estimates.
Y1  - 2020
U6  - https://doi.org/10.1038/s41560-019-0531-y
SN  - 2058-7546
VL  - 5
IS  - 1
SP  - 71
EP  - 78
PB  - Nature Publishing Group
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Rothwell, Joseph A.
A1  - Murphy, Neil
A1  - Aleksandrova, Krasimira
A1  - Schulze, Matthias Bernd
A1  - Bešević, Jelena
A1  - Kliemann, Nathalie
A1  - Jenab, Mazda
A1  - Ferrari, Pietro
A1  - Achaintre, David
A1  - Gicquiau, Audrey
A1  - Vozar, Béatrice
A1  - Scalbert, Augustin
A1  - Huybrechts, Inge
A1  - Freisling, Heinz
A1  - Prehn, Cornelia
A1  - Adamski, Jerzy
A1  - Cross, Amanda J.
A1  - Pala, Valeria Maria
A1  - Boutron-Ruault, Marie-Christine
A1  - Dahm, Christina C.
A1  - Overvad, Kim
A1  - Gram, Inger Torhild
A1  - Sandanger, Torkjel M.
A1  - Skeie, Guri
A1  - Jakszyn, Paula
A1  - Tsilidis, Kostas K.
A1  - Hughes, David J.
A1  - van Guelpen, Bethany
A1  - Bodén, Stina
A1  - Sánchez, Maria-José
A1  - Schmidt, Julie A.
A1  - Katzke, Verena
A1  - Kühn, Tilman
A1  - Colorado-Yohar, Sandra
A1  - Tumino, Rosario
A1  - Bueno-de-Mesquita, Bas
A1  - Vineis, Paolo
A1  - Masala, Giovanna
A1  - Panico, Salvatore
A1  - Eriksen, Anne Kirstine
A1  - Tjønneland, Anne
A1  - Aune, Dagfinn
A1  - Weiderpass, Elisabete
A1  - Severi, Gianluca
A1  - Chajès, Véronique
A1  - Gunter, Marc J.
T1  - Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
JF  - Clinical gastroenterology and hepatology
N2  - BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.

RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants.

CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
KW  - colorectal neoplasm
KW  - risk factors
KW  - World Cancer Research Fund/American Institute for Cancer Research Recommendations
KW  - targeted metabolomics
Y1  - 2020
U6  - https://doi.org/10.1016/j.cgh.2020.11.045
SN  - 1542-3565
SN  - 1542-7714
VL  - 20
SP  - E1061
EP  - E1082
PB  - Elsevier
CY  - New York, NY
ER  -