TY - GEN A1 - Send, T. S. A1 - Gilles, M. A1 - Codd, V. A1 - Wolf, I. A. C. A1 - Bardtke, S. A1 - Streit, Fabian A1 - Strohmaier, Jana A1 - Frank, Josef A1 - Schendel, D. A1 - Sutterlin, M. W. A1 - Denniff, M. A1 - Laucht, Manfred A1 - Samani, N. J. A1 - Deuschle, Michael A1 - Rietschel, Marcella A1 - Witt, Stephanie H. T1 - Telomere length in newborns is related to maternal stress during pregnancy Response T2 - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology KW - Predictive markers KW - Risk factors Y1 - 2018 U6 - https://doi.org/10.1038/s41386-018-0079-8 SN - 0893-133X SN - 1740-634X VL - 43 IS - 11 SP - 2164 EP - 2164 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Holz, Nathalie E. A1 - Boecker-Schlier, Regina A1 - Jennen-Steinmetz, Christine A1 - Hohm, Erika A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Baumeister, Sarah A1 - Plichta, Michael M. A1 - Esser, Günter A1 - Schmidt, Martin A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Early maternal care may counteract familial liability for psychopathology in the reward circuitry JF - Social Cognitive and Affective Neuroscience N2 - Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development. KW - maternal care KW - ADHD KW - ventral striatum KW - fMRI KW - resilience KW - aggression Y1 - 2018 U6 - https://doi.org/10.1093/scan/nsy087 SN - 1749-5016 SN - 1749-5024 VL - 13 IS - 11 SP - 1191 EP - 1201 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Boecker-Schlier, Regina A1 - Holz, Nathalie E. A1 - Hohm, Erika A1 - Zohsel, Katrin A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Baumeister, Sarah A1 - Wolf, Isabella A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Association between pubertal stage at first drink and neural reward processing in early adulthood JF - Addiction biology N2 - Puberty is a critical time period during human development. It is characterized by high levels of risk-taking behavior, such as increased alcohol consumption, and is accompanied by various neurobiological changes. Recent studies in animals and humans have revealed that the pubertal stage at first drink (PSFD) significantly impacts drinking behavior in adulthood. Moreover, neuronal alterations of the dopaminergic reward system have been associated with alcohol abuse or addiction. This study aimed to clarify the impact of PSFD on neuronal characteristics of reward processing linked to alcohol-related problems. One hundred sixty-eight healthy young adults from a prospective study covering 25 years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. PSFD was determined according to the age at menarche or Tanner stage of pubertal development, respectively. Alcohol-related problems in early adulthood were assessed with the Alcohol Use Disorder Identification Test (AUDIT). During reward anticipation, decreased fMRI activation of the frontal cortex and increased preparatory EEG activity (contingent negative variation) occurred with pubertal compared to postpubertal first alcohol intake. Moreover, alcohol-related problems during early adulthood were increased in pubertal compared to postpubertal beginners, which was mediated by neuronal activation of the right medial frontal gyrus. At reward delivery, increased fMRI activation of the left caudate and higher feedback-related EEG negativity were detected in pubertal compared to postpubertal beginners. Together with animal findings, these results implicate PSFD as a potential modulator of psychopathology, involving altered reward anticipation. Both PSFD timing and reward processing might thus be potential targets for early prevention and intervention. KW - alcohol-related problems KW - electroencephalography KW - functional magnetic resonance imaging KW - puberty KW - reward processing Y1 - 2017 U6 - https://doi.org/10.1111/adb.12413 SN - 1355-6215 SN - 1369-1600 VL - 22 SP - 1402 EP - 1415 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - McLoughlin, Grainne A1 - Palmer, Jason A1 - Makeig, Scott A1 - Bigdely-Shamlo, Nima A1 - Banaschewski, Tobias A1 - Laucht, Manfred A1 - Brandeis, D. T1 - EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes JF - Brain Topography N2 - Cognitive or executive control is a critical mental ability, an important marker of mental illness, and among the most heritable of neurocognitive traits. Two candidate genes, catechol-O-methyltransferase (COMT) and DRD4, which both have a roles in the regulation of cortical dopamine, have been consistently associated with cognitive control. Here, we predicted that individuals with the COMT Met/Met allele would show improved response execution and inhibition as indexed by event-related potentials in a Go/NoGo task, while individuals with the DRD4 7-repeat allele would show impaired brain activity. We used independent component analysis (ICA) to separate brain source processes contributing to high-density EEG scalp signals recorded during the task. As expected, individuals with the DRD4 7-repeat polymorphism had reduced parietal P3 source and scalp responses to response (Go) compared to those without the 7-repeat. Contrary to our expectation, the COMT homozygous Met allele was associated with a smaller frontal P3 source and scalp response to response-inhibition (NoGo) stimuli, suggesting that while more dopamine in frontal cortical areas has advantages in some tasks, it may also compromise response inhibition function. An interaction effect emerged for P3 source responses to Go stimuli. These were reduced in those with both the 7-repeat DRD4 allele and either the COMT Val/Val or the Met/Met homozygous polymorphisms but not in those with the heterozygous Val/Met polymorphism. This epistatic interaction between DRD4 and COMT replicates findings that too little or too much dopamine impairs cognitive control. The anatomic and functional separated maximally independent cortical EEG sources proved more informative than scalp channel measures for genetic studies of brain function and thus better elucidate the complex mechanisms in psychiatric illness. KW - EEG KW - Genetics KW - DRD4 KW - COMT KW - ICA KW - Measure projection Y1 - 2017 U6 - https://doi.org/10.1007/s10548-017-0601-z SN - 0896-0267 SN - 1573-6792 VL - 31 IS - 3 SP - 392 EP - 406 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Hohm, Erika A1 - Zohsel, Katrin A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Beeinträchtigter Start ins Leben T1 - Impaired Start into Life BT - Langfristige Auswirkungen der postpartalen Depression und der Einfluss des mütterlichen Interaktionsverhaltens BT - Long-Term Effects of Postpartum Depression and the Role of Maternal Interactional Behavior JF - Kindheit und Entwicklung N2 - Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern. N2 - Postpartum depression (PPD) is a common and serious mental health problem with prevalence rates ranging from 13% to 19%, and is associated with an increased risk of adverse child development. PPD is characterized by symptoms common of depression, particularly by impairments of maternity, parenting, and mother-infant interactions. Several reviews suggest an impact on attachment, cognitive, behavioral, and health-related outcome in the offspring. However, the long-term effects of PPD regarding cognitive and mental development into adulthood and the underlying mechanisms, especially the role of maternal interactional behavior, are not yet well understood. In the Mannheim Study of Children at Risk, maternal depression was assessed when the child was 3 months and 2 years old. Development from infancy to young adulthood (25 years) was assessed at regular intervals in 28 children of postnatally depressed mothers and 107 children born to mentally healthy mothers. Cognitive outcome up to age 11 was measured using standardized instruments; in adulthood, school outcome was used approximately. Psychiatric diagnosis as well as symptom scores served as psychological outcome. At age 3 months, mothers and infants were videotaped during a nursing and a playing situation. Videotapes of the 10-min session were recorded and evaluated by trained raters (kappa > .83) using the Category System for Microanalysis of Early Mother Child Interaction (Esser, Scheven, et al., 1989). The cognitive as well as social-emotional outcome of children of mothers suffering from PPD was significantly poorer than in the children of mentally healthy mothers. The adverse effects were more pronounced during childhood. The offspring of postnatally depressed mothers who interacted in a responsive manner with their infant exhibited a better prognosis in contrast to those with mothers interacting less sensitively. This effect was observed with regard to cognitive development and symptoms of externalizing behavior at age 19 years. Regarding internalizing behavior, no impact of maternal behavior was detected. These findings emphasize the importance of high-quality early mother-child interaction in the development of children at risk. Furthermore, convincing arguments are given for very early specialized treatment of impaired mother-child interactions in mothers suffering from PPD. The PPD treatment should always comprise treatment of depression as well as treatment of the disturbed mother-child interaction. KW - postpartum depression KW - development KW - longitudinal study KW - Mannheim Study of Children at Risk KW - mother-child interaction KW - Postpartale+Depression KW - Entwicklung KW - Längsschnittstudie KW - Mannheimer+Risikokinderstudie KW - Mutter-Kind-Interaktion Y1 - 2017 U6 - https://doi.org/10.1026/0942-5403/a000234 SN - 0942-5403 SN - 2190-6246 VL - 26 SP - 210 EP - 220 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Die langfristigen Auswirkungen von Frühgeburtlichkeit auf kognitive Entwicklung und Schulerfolg T1 - Long-term consequences of preterm birth on cognitive development and academic achievement BT - Gibt es einen protektiven Effekt mütterlicher Responsivität? BT - Is there a protective effect of maternal responsiveness? JF - Kindheit und Entwicklung N2 - In einer prospektiven Längsschnittstudie wurde der Zusammenhang zwischen früher Responsivität der Mutter und kognitiver Entwicklung ihrer früh- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde dafür die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 frühgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 frühgeboren) zusätzlich der höchste erreichte Schulabschluss bis 25 Jahren erhoben. Frühgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem für mögliche konfundierende Faktoren kontrolliert worden war. Nur bei Früh-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen mütterlicher Responsivität und IQ. Für die Wahrscheinlichkeit einen höheren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Frühgeburtlichkeit noch von mütterlicher Responsivität. N2 - Preterm birth is associated with adverse long-term consequences regarding cognitive development. Whereas children born very preterm represent a subgroup at special risk, so-called late preterms are also affected to a lesser degree. Effects of prematurity can be observed until adulthood. For example, decreased wealth was reported in adults born preterm, which was mediated by decreased intelligence during childhood and lower educational qualifications during young adulthood. Hence, it is highly relevant to examine whether certain factors can buffer against the adverse effects of preterm birth on cognitive development. Parenting might play an important role here. There is evidence suggesting a protective effect of sensitive parenting during childhood on later cognitive outcome in preterms. In the current study, we examined whether early responsive maternal care was associated with later intelligence and academic achievement in children born preterm versus full term. As part of an ongoing cohort study, early maternal responsiveness was assessed at the child’s age of 3 months (adjusted for gestational age) during a nursing and playing situation. At age 11 years, general intelligence (IQ) was determined in n = 351 children (101 born preterm; 168 male). Until age 25 years, educational qualification was assessed in n = 313 participants (85 born preterm; 145 male). IQ at age 11 was significantly lower in preterms compared with full-term subjects after adjusting for potential confounders like maternal educational background and early psychosocial risk. A significant interaction between preterm birth and early maternal responsiveness was detected. In preterms only, higher levels of early maternal responsiveness were significantly associated with higher child IQ. Lower IQs in children born preterm as compared with those born full term were observed in the subaverage-to-average range of maternal responsiveness. Interestingly, preterms exposed to very high levels of maternal responsiveness showed slightly higher IQs when compared with children born at term. With regard to academic achievement, neither a significant effect of preterm birth nor of early maternal responsiveness occurred after adjusting for potential confounders. The results of the current study replicate and extend earlier findings with regard to a protective effect of sensitive parenting on childhood cognitive outcome in preterms. The lacking impact of prematurity on academic achievement may be explained by the exclusion of participants with IQs outside the normal range in the current study. Interventions enhancing early responsive care in parents of preterms may be advisable. More studies on long-term outcomes of such interventions on cognitive development are encouraged. KW - preterm birth KW - parental quality KW - cognitive development KW - longitudinal study KW - Mannheim Study of Children at Risk KW - Frühgeburt KW - Elternverhalten KW - kognitive Entwicklung KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie Y1 - 2017 U6 - https://doi.org/10.1026/0942-5403/a000235 SN - 0942-5403 SN - 2190-6246 VL - 26 SP - 221 EP - 229 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Wolf, Isabell Ann-Cathrin A1 - Gilles, Maria A1 - Peus, Verena A1 - Scharnholz, Barbara A1 - Seibert, Julia A1 - Jennen-Steinmetz, Christine A1 - Krumm, Bertram A1 - Rietschel, Marcella A1 - Deuschle, Michael A1 - Laucht, Manfred T1 - Impact of prenatal stress on mother-infant dyadic behavior during the still-face paradigm JF - Borderline Personality Disorder and Emotion Dysregulation : the official journal of the National Education Alliance for Borderline Personality Disorder (NEA.BPD) and Dachverband Dialektisch Behaviorale Therapie (DDBT) N2 - Background: Mother-infant interaction provides important training for the infant’s ability to cope with stress and the development of resilience. Prenatal stress (PS) and its impact on the offspring’s development have long been a focus of stress research, with studies highlighting both harmful and beneficial effects. The aim of the current study was to examine the possible influence of both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy with mother-child dyadic behavior following stress exposure. Methods: The behavior of 164 mother-infant dyads during the still-face situation was filmed at six months postpartum and coded into three dyadic patterns: 1) both positive, 2) infant protesting-mother positive, and 3) infant protesting-mother negative. PS exposure was assessed prenatally according to psychological measures (i.e., psychopathological, perceived and psychosocial PS; n = 164) and HPA axis activity measures (maternal salivary cortisol, i.e., cortisol decline and area under the curve with respect to ground (AUCg); n = 134). Results: Mother-infant dyads in both the high- and low-stress groups showed decreasing positive and increasing negative dyadic behavior in the reunion episode, which is associated with the well-known “still-face” and “carry-over” effect. Furthermore, mother-infant dyads with higher psychosocial PS exhibited significantly more positive dyadic behavior than the low psychosocial PS group in the first play episode, but not in the reunion episode. Similarly, mother-infant dyads with high HPA axis activity (i.e. high AUCg) but steeper diurnal cortisol decline (i.e. cortisol decline) displayed significantly less negative behavior in the reunion episode than dyads with low HPA axis activity. No significant results were found for psychopathological stress and perceived stress. Conclusions: The results suggest a beneficial effect of higher psychosocial PS and higher prenatal maternal HPA axis activity in late gestation, which is in line with “stress inoculation” theories. KW - Prenatal stress KW - Face-to-face still-face paradigm KW - Resilience KW - Psychosocial stress KW - Cortisol Y1 - 2018 U6 - https://doi.org/10.1186/s40479-018-0078-8 SN - 2051-6673 VL - 5 PB - BioMed Central CY - London ER - TY - JOUR A1 - Hohm, Erika A1 - Laucht, Manfred A1 - Zohsel, Katrin A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias T1 - Resilienz und Ressourcen im Verlauf der Entwicklung T1 - Resilience and Resources During Development BT - Von der frühen Kindheit bis zum Erwachsenenalter BT - From Early Childhood to Adulthood JF - Kindheit und Entwicklung N2 - Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen beschäftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines familiären Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen können. Eine besondere Rolle kommt dabei positiven frühen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese schützen Risikokinder davor, eine ungünstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ungünstiger „Startbedingungen“ positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen ermöglichen es Risikokindern auch unter widrigen Lebensumständen (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverhältnissen) erfolgreich zu bestehen. Darüber hinaus zeigt die Arbeit, dass Resilienz ein Persönlichkeitsmerkmal ist, das ab dem frühen Erwachsenenalter eine hohe Stabilität besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern. N2 - Resilience refers to the ability to successfully deal with stressful life circumstances and experiences and to cope with them. Based on data from the Mannheim Study of Children at Risk, which follows a sample of children at risk from birth to adulthood, the present paper provides convincing evidence demonstrating how protective factors in the child and his/her family environment operate during the course of development to contribute to the development of resilience. As shown, a major role is assigned to positive early parent–child relationships (both mother– and father–child interactions). Moreover, positive interactive experiences at the child’s age of 2 years play a significant role. These experiences consistently contribute to a positive child development in the face of adversity. In addition to characteristics of the social environment of the child, cognitive, social–emotional, and internal competencies during childhood, youth, and young adulthood play a major role in the development of resilience. These competencies enable children at risk who are growing up in psychosocial high-risk families or in poverty to successfully cope with conditions of high adversity. Moreover, the findings presented here demonstrate that resilience may be conceived as a personal characteristic that exhibits high stability since young adulthood. With these findings, the present study points to the significance of resilience in predicting the long-term outcome of children at risk. KW - protective factors KW - risk factors KW - longitudinal study KW - Mannheim Study of Children at Risk KW - early parent-child relationship KW - Schutzfaktoren KW - Risikofaktoren KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - frühe Eltern-Kind-Beziehung Y1 - 2018 U6 - https://doi.org/10.1026/0942-5403/a000236 SN - 0942-5403 SN - 2190-6246 VL - 26 SP - 230 EP - 239 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Witt, Stephanie H. A1 - Frank, Josef A1 - Gilles, Maria A1 - Lang, Maren A1 - Treutlein, Jens A1 - Streit, Fabian A1 - Wolf, Isabell A. C. A1 - Peus, Verena A1 - Scharnholz, Barbara A1 - Send, Tabea S. A1 - Heilmann-Heimbach, Stefanie A1 - Sivalingam, Sugirthan A1 - Dukal, Helene A1 - Strohmaier, Jana A1 - Sütterlin, Marc A1 - Arloth, Janine A1 - Laucht, Manfred A1 - Nöthen, Markus M. A1 - Deuschle, Michael A1 - Rietschel, Marcella T1 - Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation JF - BMC genomics N2 - Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels. Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females. Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top "smoking methylation pattern" genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns. Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight. KW - DNA methylation KW - Smoking KW - Birth weight KW - Mediation analysis Y1 - 2018 U6 - https://doi.org/10.1186/s12864-018-4652-7 SN - 1471-2164 VL - 19 PB - BMC CY - London ER - TY - GEN A1 - Hohm, Erika A1 - Zohsel, Katrin A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Beeinträchtigter Start ins Leben BT - Langfristige Auswirkungen der postpartalen Depression und der Einfluss des mütterlichen Interaktionsverhaltens T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Postpartale Depressionen sind häufige und schwerwiegende psychische Erkrankungen mit ungünstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die frühe Mutter-Kind-Interaktion. Über die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder Mütter konnten mit 25 Jahren untersucht werden. Beeinträchtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver Mütter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives mütterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualität der Mutter-Kind-Interaktion für die Entwicklung von Risikokindern. N2 - Postpartum depression (PPD) is a common and serious mental health problem with prevalence rates ranging from 13 % to 19 %, and is associated with an increased risk of adverse child development. PPD is characterized by symptoms common of depression, particularly by impairments of maternity, parenting, and mother–infant interactions. Several reviews suggest an impact on attachment, cognitive, behavioral, and health-related outcome in the offspring. However, the long-term effects of PPD regarding cognitive and mental development into adulthood and the underlying mechanisms, especially the role of maternal interactional behavior, are not yet well understood. In the Mannheim Study of Children at Risk, maternal depression was assessed when the child was 3 months and 2 years old. Development from infancy to young adulthood (25 years) was assessed at regular intervals in 28 children of postnatally depressed mothers and 107 children born to mentally healthy mothers. Cognitive outcome up to age 11 was measured using standardized instruments; in adulthood, school outcome was used approximately. Psychiatric diagnosis as well as symptom scores served as psychological outcome. At age 3 months, mothers and infants were videotaped during a nursing and a playing situation. Videotapes of the 10-min session were recorded and evaluated by trained raters (κ > .83) using the Category System for Microanalysis of Early Mother Child Interaction (Esser, Scheven, et al., 1989). The cognitive as well as social–emotional outcome of children of mothers suffering from PPD was significantly poorer than in the children of mentally healthy mothers. The adverse effects were more pronounced during childhood. The offspring of postnatally depressed mothers who interacted in a responsive manner with their infant exhibited a better prognosis in contrast to those with mothers interacting less sensitively. This effect was observed with regard to cognitive development and symptoms of externalizing behavior at age 19 years. Regarding internalizing behavior, no impact of maternal behavior was detected. These findings emphasize the importance of high-quality early mother–child interaction in the development of children at risk. Furthermore, convincing arguments are given for very early specialized treatment of impaired mother–child interactions in mothers suffering from PPD. The PPD treatment should always comprise treatment of depression as well as treatment of the disturbed mother–child interaction. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 692 KW - Postpartale Depression KW - Entwicklung KW - Längsschnittstudie KW - Mannheimer Risikokinderstudie KW - Mutter-Kind-Interaktion KW - postpartum depression KW - development KW - longitudinal study KW - Mannheim Study of Children at Risk KW - mother–child interaction Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433406 SN - 1866-8364 IS - 692 ER -