TY  - JOUR
A1  - Abdo, A. A.
A1  - Ackermann, Margit
A1  - Ajello, M.
A1  - Allafort, A. J.
A1  - Baldini, L.
A1  - Ballet, J.
A1  - Barbiellini, G.
A1  - Baring, M. G.
A1  - Bastieri, D.
A1  - Bellazzini, R.
A1  - Berenji, B.
A1  - Blandford, R. D.
A1  - Bloom, E. D.
A1  - Bonamente, E.
A1  - Borgland, A. W.
A1  - Bouvier, A.
A1  - Brandt, T. J.
A1  - Bregeon, Johan
A1  - Brigida, M.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Buson, S.
A1  - Caliandro, G. A.
A1  - Cameron, R. A.
A1  - Caraveo, P. A.
A1  - Casandjian, J. M.
A1  - Cecchi, C.
A1  - Chaty, S.
A1  - Chekhtman, A.
A1  - Cheung, C. C.
A1  - Chiang, J.
A1  - Cillis, A. N.
A1  - Ciprini, S.
A1  - Claus, R.
A1  - Cohen-Tanugi, J.
A1  - Conrad, Jan
A1  - Corbel, S.
A1  - Cutini, S.
A1  - de Angelis, A.
A1  - de Palma, F.
A1  - Dermer, C. D.
A1  - Digel, S. W.
A1  - do Couto e Silva, E.
A1  - Drell, P. S.
A1  - Drlica-Wagner, A.
A1  - Dubois, R.
A1  - Dumora, D.
A1  - Favuzzi, C.
A1  - Ferrara, E. C.
A1  - Fortin, P.
A1  - Frailis, M.
A1  - Fukazawa, Y.
A1  - Fukui, Y.
A1  - Funk, S.
A1  - Fusco, P.
A1  - Gargano, F.
A1  - Gasparrini, D.
A1  - Gehrels, N.
A1  - Germani, S.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Glanzman, T.
A1  - Godfrey, G.
A1  - Grenier, I. A.
A1  - Grondin, M. -H.
A1  - Guiriec, S.
A1  - Hadasch, D.
A1  - Hanabata, Y.
A1  - Harding, A. K.
A1  - Hayashida, M.
A1  - Hayashi, K.
A1  - Hays, E.
A1  - Horan, D.
A1  - Jackson, M. S.
A1  - Johannesson, G.
A1  - Johnson, A. S.
A1  - Kamae, T.
A1  - Katagiri, H.
A1  - Kataoka, J.
A1  - Kerr, M.
A1  - Knoedlseder, J.
A1  - Kuss, M.
A1  - Lande, J.
A1  - Latronico, L.
A1  - Lee, S. -H.
A1  - Lemoine-Goumard, M.
A1  - Longo, F.
A1  - Loparco, F.
A1  - Lovellette, M. N.
A1  - Lubrano, P.
A1  - Madejski, G. M.
A1  - Makeev, A.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Michelson, P. F.
A1  - Mignani, R. P.
A1  - Mitthumsiri, W.
A1  - Mizuno, T.
A1  - Moiseev, A. A.
A1  - Monte, C.
A1  - Monzani, M. E.
A1  - Morselli, A.
A1  - Moskalenko, I. V.
A1  - Murgia, S.
A1  - Naumann-Godo, M.
A1  - Nolan, P. L.
A1  - Norris, J. P.
A1  - Nuss, E.
A1  - Ohsugi, T.
A1  - Okumura, A.
A1  - Orlando, E.
A1  - Ormes, J. F.
A1  - Paneque, D.
A1  - Parent, D.
A1  - Pelassa, V.
A1  - Pesce-Rollins, M.
A1  - Pierbattista, M.
A1  - Piron, F.
A1  - Pohl, Martin
A1  - Porter, T. A.
A1  - Raino, S.
A1  - Rando, R.
A1  - Razzano, M.
A1  - Reimer, O.
A1  - Reposeur, T.
A1  - Ritz, S.
A1  - Romani, R. W.
A1  - Roth, M.
A1  - Sadrozinski, H. F. -W.
A1  - Parkinson, P. M. Saz
A1  - Sgro, C.
A1  - Smith, D. A.
A1  - Smith, P. D.
A1  - Spandre, G.
A1  - Spinelli, P.
A1  - Strickman, M. S.
A1  - Tajima, H.
A1  - Takahashi, H.
A1  - Takahashi, T.
A1  - Tanaka, T.
A1  - Thayer, J. G.
A1  - Thayer, J. B.
A1  - Thompson, D. J.
A1  - Tibaldo, L.
A1  - Tibolla, O.
A1  - Torres, D. F.
A1  - Tosti, G.
A1  - Tramacere, A.
A1  - Troja, E.
A1  - Uchiyama, Y.
A1  - Vandenbroucke, J.
A1  - Vasileiou, V.
A1  - Vianello, G.
A1  - Vilchez, N.
A1  - Vitale, V.
A1  - Waite, A. P.
A1  - Wang, P.
A1  - Winer, B. L.
A1  - Wood, K. S.
A1  - Yamamoto, H.
A1  - Yamazaki, R.
A1  - Yang, Z.
A1  - Ziegler, M.
T1  - Observations of the young supernova remnant RX J1713.7-3946 with the fermi large area telescope
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0 degrees.55 +/- 0 degrees.04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Gamma = 1.5 +/- 0.1 that coincides in normalization with the steeper H. E. S. S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
KW  - acceleration of particles
KW  - gamma rays: general
KW  - gamma rays: ISM
KW  - ISM: individual objects (RX J1713.7-3946)
KW  - ISM: supernova remnants
KW  - radiation mechanisms: non-thermal
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/734/1/28
SN  - 0004-637X
VL  - 734
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Acciari, V. A.
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Christiansen, J. L.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Duke, C.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Jackson, D. J.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Newbold, M. D.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Sentuerk, G. D.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Swordy, S. P.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Wood, M.
T1  - Veritas observations of gamma-ray bursts detected by swift
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present the results of 16 Swift-triggered Gamma-ray burst (GRB) follow-up observations taken with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) telescope array from 2007 January to 2009 June. The median energy threshold and response time of these observations were 260 GeV and 320 s, respectively. Observations had an average duration of 90 minutes. Each burst is analyzed independently in two modes: over the whole duration of the observations and again over a shorter timescale determined by the maximum VERITAS sensitivity to a burst with a t(-1.5) time profile. This temporal model is characteristic of GRB afterglows with high-energy, long-lived emission that have been detected by the Large Area Telescope on board the Fermi satellite. No significant very high energy (VHE) gamma-ray emission was detected and upper limits above the VERITAS threshold energy are calculated. The VERITAS upper limits are corrected for gamma-ray extinction by the extragalactic background light and interpreted in the context of the keV emission detected by Swift. For some bursts the VHE emission must have less power than the keV emission, placing constraints on inverse Compton models of VHE emission.
KW  - astroparticle physics
KW  - gamma-ray burst: general
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/743/1/62
SN  - 0004-637X
VL  - 743
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Tiegs, Scott D.
A1  - Costello, David M.
A1  - Isken, Mark W.
A1  - Woodward, Guy
A1  - McIntyre, Peter B.
A1  - Gessner, Mark O.
A1  - Chauvet, Eric
A1  - Griffiths, Natalie A.
A1  - Flecker, Alex S.
A1  - Acuna, Vicenc
A1  - Albarino, Ricardo
A1  - Allen, Daniel C.
A1  - Alonso, Cecilia
A1  - Andino, Patricio
A1  - Arango, Clay
A1  - Aroviita, Jukka
A1  - Barbosa, Marcus V. M.
A1  - Barmuta, Leon A.
A1  - Baxter, Colden V.
A1  - Bell, Thomas D. C.
A1  - Bellinger, Brent
A1  - Boyero, Luz
A1  - Brown, Lee E.
A1  - Bruder, Andreas
A1  - Bruesewitz, Denise A.
A1  - Burdon, Francis J.
A1  - Callisto, Marcos
A1  - Canhoto, Cristina
A1  - Capps, Krista A.
A1  - Castillo, Maria M.
A1  - Clapcott, Joanne
A1  - Colas, Fanny
A1  - Colon-Gaud, Checo
A1  - Cornut, Julien
A1  - Crespo-Perez, Veronica
A1  - Cross, Wyatt F.
A1  - Culp, Joseph M.
A1  - Danger, Michael
A1  - Dangles, Olivier
A1  - de Eyto, Elvira
A1  - Derry, Alison M.
A1  - Diaz Villanueva, Veronica
A1  - Douglas, Michael M.
A1  - Elosegi, Arturo
A1  - Encalada, Andrea C.
A1  - Entrekin, Sally
A1  - Espinosa, Rodrigo
A1  - Ethaiya, Diana
A1  - Ferreira, Veronica
A1  - Ferriol, Carmen
A1  - Flanagan, Kyla M.
A1  - Fleituch, Tadeusz
A1  - Shah, Jennifer J. Follstad
A1  - Frainer, Andre
A1  - Friberg, Nikolai
A1  - Frost, Paul C.
A1  - Garcia, Erica A.
A1  - Lago, Liliana Garcia
A1  - Garcia Soto, Pavel Ernesto
A1  - Ghate, Sudeep
A1  - Giling, Darren P.
A1  - Gilmer, Alan
A1  - Goncalves, Jose Francisco
A1  - Gonzales, Rosario Karina
A1  - Graca, Manuel A. S.
A1  - Grace, Mike
A1  - Grossart, Hans-Peter
A1  - Guerold, Francois
A1  - Gulis, Vlad
A1  - Hepp, Luiz U.
A1  - Higgins, Scott
A1  - Hishi, Takuo
A1  - Huddart, Joseph
A1  - Hudson, John
A1  - Imberger, Samantha
A1  - Iniguez-Armijos, Carlos
A1  - Iwata, Tomoya
A1  - Janetski, David J.
A1  - Jennings, Eleanor
A1  - Kirkwood, Andrea E.
A1  - Koning, Aaron A.
A1  - Kosten, Sarian
A1  - Kuehn, Kevin A.
A1  - Laudon, Hjalmar
A1  - Leavitt, Peter R.
A1  - Lemes da Silva, Aurea L.
A1  - Leroux, Shawn J.
A1  - Leroy, Carri J.
A1  - Lisi, Peter J.
A1  - MacKenzie, Richard
A1  - Marcarelli, Amy M.
A1  - Masese, Frank O.
A1  - Mckie, Brendan G.
A1  - Oliveira Medeiros, Adriana
A1  - Meissner, Kristian
A1  - Milisa, Marko
A1  - Mishra, Shailendra
A1  - Miyake, Yo
A1  - Moerke, Ashley
A1  - Mombrikotb, Shorok
A1  - Mooney, Rob
A1  - Moulton, Tim
A1  - Muotka, Timo
A1  - Negishi, Junjiro N.
A1  - Neres-Lima, Vinicius
A1  - Nieminen, Mika L.
A1  - Nimptsch, Jorge
A1  - Ondruch, Jakub
A1  - Paavola, Riku
A1  - Pardo, Isabel
A1  - Patrick, Christopher J.
A1  - Peeters, Edwin T. H. M.
A1  - Pozo, Jesus
A1  - Pringle, Catherine
A1  - Prussian, Aaron
A1  - Quenta, Estefania
A1  - Quesada, Antonio
A1  - Reid, Brian
A1  - Richardson, John S.
A1  - Rigosi, Anna
A1  - Rincon, Jose
A1  - Risnoveanu, Geta
A1  - Robinson, Christopher T.
A1  - Rodriguez-Gallego, Lorena
A1  - Royer, Todd V.
A1  - Rusak, James A.
A1  - Santamans, Anna C.
A1  - Selmeczy, Geza B.
A1  - Simiyu, Gelas
A1  - Skuja, Agnija
A1  - Smykla, Jerzy
A1  - Sridhar, Kandikere R.
A1  - Sponseller, Ryan
A1  - Stoler, Aaron
A1  - Swan, Christopher M.
A1  - Szlag, David
A1  - Teixeira-de Mello, Franco
A1  - Tonkin, Jonathan D.
A1  - Uusheimo, Sari
A1  - Veach, Allison M.
A1  - Vilbaste, Sirje
A1  - Vought, Lena B. M.
A1  - Wang, Chiao-Ping
A1  - Webster, Jackson R.
A1  - Wilson, Paul B.
A1  - Woelfl, Stefan
A1  - Xenopoulos, Marguerite A.
A1  - Yates, Adam G.
A1  - Yoshimura, Chihiro
A1  - Yule, Catherine M.
A1  - Zhang, Yixin X.
A1  - Zwart, Jacob A.
T1  - Global patterns and drivers of ecosystem functioning in rivers and riparian zones
JF  - Science Advances
N2  - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Y1  - 2019
U6  - https://doi.org/10.1126/sciadv.aav0486
SN  - 2375-2548
VL  - 5
IS  - 1
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Chipman, Ariel D.
A1  - Ferrier, David E. K.
A1  - Brena, Carlo
A1  - Qu, Jiaxin
A1  - Hughes, Daniel S. T.
A1  - Schroeder, Reinhard
A1  - Torres-Oliva, Montserrat
A1  - Znassi, Nadia
A1  - Jiang, Huaiyang
A1  - Almeida, Francisca C.
A1  - Alonso, Claudio R.
A1  - Apostolou, Zivkos
A1  - Aqrawi, Peshtewani
A1  - Arthur, Wallace
A1  - Barna, Jennifer C. J.
A1  - Blankenburg, Kerstin P.
A1  - Brites, Daniela
A1  - Capella-Gutierrez, Salvador
A1  - Coyle, Marcus
A1  - Dearden, Peter K.
A1  - Du Pasquier, Louis
A1  - Duncan, Elizabeth J.
A1  - Ebert, Dieter
A1  - Eibner, Cornelius
A1  - Erikson, Galina
A1  - Evans, Peter D.
A1  - Extavour, Cassandra G.
A1  - Francisco, Liezl
A1  - Gabaldon, Toni
A1  - Gillis, William J.
A1  - Goodwin-Horn, Elizabeth A.
A1  - Green, Jack E.
A1  - Griffiths-Jones, Sam
A1  - Grimmelikhuijzen, Cornelis J. P.
A1  - Gubbala, Sai
A1  - Guigo, Roderic
A1  - Han, Yi
A1  - Hauser, Frank
A1  - Havlak, Paul
A1  - Hayden, Luke
A1  - Helbing, Sophie
A1  - Holder, Michael
A1  - Hui, Jerome H. L.
A1  - Hunn, Julia P.
A1  - Hunnekuhl, Vera S.
A1  - Jackson, LaRonda
A1  - Javaid, Mehwish
A1  - Jhangiani, Shalini N.
A1  - Jiggins, Francis M.
A1  - Jones, Tamsin E.
A1  - Kaiser, Tobias S.
A1  - Kalra, Divya
A1  - Kenny, Nathan J.
A1  - Korchina, Viktoriya
A1  - Kovar, Christie L.
A1  - Kraus, F. Bernhard
A1  - Lapraz, Francois
A1  - Lee, Sandra L.
A1  - Lv, Jie
A1  - Mandapat, Christigale
A1  - Manning, Gerard
A1  - Mariotti, Marco
A1  - Mata, Robert
A1  - Mathew, Tittu
A1  - Neumann, Tobias
A1  - Newsham, Irene
A1  - Ngo, Dinh N.
A1  - Ninova, Maria
A1  - Okwuonu, Geoffrey
A1  - Ongeri, Fiona
A1  - Palmer, William J.
A1  - Patil, Shobha
A1  - Patraquim, Pedro
A1  - Pham, Christopher
A1  - Pu, Ling-Ling
A1  - Putman, Nicholas H.
A1  - Rabouille, Catherine
A1  - Ramos, Olivia Mendivil
A1  - Rhodes, Adelaide C.
A1  - Robertson, Helen E.
A1  - Robertson, Hugh M.
A1  - Ronshaugen, Matthew
A1  - Rozas, Julio
A1  - Saada, Nehad
A1  - Sanchez-Gracia, Alejandro
A1  - Scherer, Steven E.
A1  - Schurko, Andrew M.
A1  - Siggens, Kenneth W.
A1  - Simmons, DeNard
A1  - Stief, Anna
A1  - Stolle, Eckart
A1  - Telford, Maximilian J.
A1  - Tessmar-Raible, Kristin
A1  - Thornton, Rebecca
A1  - van der Zee, Maurijn
A1  - von Haeseler, Arndt
A1  - Williams, James M.
A1  - Willis, Judith H.
A1  - Wu, Yuanqing
A1  - Zou, Xiaoyan
A1  - Lawson, Daniel
A1  - Muzny, Donna M.
A1  - Worley, Kim C.
A1  - Gibbs, Richard A.
A1  - Akam, Michael
A1  - Richards, Stephen
T1  - The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
JF  - PLoS biology
N2  - Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pbio.1002005
SN  - 1545-7885
VL  - 12
IS  - 11
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Fujihara, Kenji M.
A1  - Zhang, Bonnie Z.
A1  - Jackson, Thomas D.
A1  - Ogunkola, Moses
A1  - Nijagal, Brunda
A1  - Milne, Julia V.
A1  - Sallman, David A.
A1  - Ang, Ching-Seng
A1  - Nikolic, Iva
A1  - Kearney, Conor J.
A1  - Hogg, Simon J.
A1  - Cabalag, Carlos S.
A1  - Sutton, Vivien R.
A1  - Watt, Sally
A1  - Fujihara, Asuka T.
A1  - Trapani, Joseph A.
A1  - Simpson, Kaylene J.
A1  - Stojanovski, Diana
A1  - Leimkühler, Silke
A1  - Haupt, Sue
A1  - Phillips, Wayne A.
A1  - Clemons, Nicholas J.
T1  - Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
JF  - Science Advances
N2  - The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, al-though the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator. Using unbiased approaches, this study demonstrates that eprenetapopt depletes cellular antioxidant glutathione levels by increasing its turnover, triggering a nonapoptotic, iron-dependent form of cell death known as ferroptosis. Deficiency in genes responsible for supplying cancer cells with the substrates for de novo glutathione synthesis (SLC7A11, SHMT2, and MTHFD1L), as well as the enzymes required to synthesize glutathione (GCLC and GCLM), augments the activity of eprenetapopt. Eprenetapopt also inhibits iron-sulfur cluster biogenesis by limit-ing the cysteine desulfurase activity of NFS1, which potentiates ferroptosis and may restrict cellular proliferation. The combination of eprenetapopt with dietary serine and glycine restriction synergizes to inhibit esophageal xenograft tumor growth. These findings reframe the canonical view of eprenetapopt from a mutant-p53 reactivator to a ferroptosis inducer.
Y1  - 2022
U6  - https://doi.org/10.1126/sciadv.abm9427
SN  - 2375-2548
VL  - 8
IS  - 37
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  -