TY  - JOUR
A1  - Acero, F.
A1  - Aloisio, R.
A1  - Amans, J.
A1  - Amato, Elena
A1  - Antonelli, L. A.
A1  - Aramo, C.
A1  - Armstrong, T.
A1  - Arqueros, F.
A1  - Asano, Katsuaki
A1  - Ashley, M.
A1  - Backes, M.
A1  - Balazs, C.
A1  - Balzer, A.
A1  - Bamba, Aya
A1  - Barkov, Maxim
A1  - Barrio, J. A.
A1  - Benbow, Wystan
A1  - Bernloehr, K.
A1  - Beshley, V.
A1  - Bigongiari, C.
A1  - Biland, A.
A1  - Bilinsky, A.
A1  - Bissaldi, Elisabetta
A1  - Biteau, J.
A1  - Blanch, O.
A1  - Blasi, P.
A1  - Blazek, J.
A1  - Boisson, C.
A1  - Bonanno, G.
A1  - Bonardi, A.
A1  - Bonavolonta, C.
A1  - Bonnoli, G.
A1  - Braiding, C.
A1  - Brau-Nogue, S.
A1  - Bregeon, J.
A1  - Brown, A. M.
A1  - Bugaev, V.
A1  - Bulgarelli, A.
A1  - Bulik, T.
A1  - Burton, Michael
A1  - Burtovoi, A.
A1  - Busetto, G.
A1  - Bottcher, M.
A1  - Cameron, R.
A1  - Capalbi, M.
A1  - Caproni, Anderson
A1  - Caraveo, P.
A1  - Carosi, R.
A1  - Cascone, E.
A1  - Cerruti, M.
A1  - Chaty, Sylvain
A1  - Chen, A.
A1  - Chen, X.
A1  - Chernyakova, M.
A1  - Chikawa, M.
A1  - Chudoba, J.
A1  - Cohen-Tanugi, J.
A1  - Colafrancesco, S.
A1  - Conforti, V.
A1  - Contreras, J. L.
A1  - Costa, A.
A1  - Cotter, G.
A1  - Covino, Stefano
A1  - Covone, G.
A1  - Cumani, P.
A1  - Cusumano, G.
A1  - Daniel, M.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Cesare, G.
A1  - De Franco, A.
A1  - De Frondat, F.
A1  - Dal Pino, E. M. de Gouveia
A1  - De Lisio, C.
A1  - Lopez, R. de los Reyes
A1  - De Lotto, B.
A1  - de Naurois, M.
A1  - De Palma, F.
A1  - Del Santo, M.
A1  - Delgado, C.
A1  - della Volpe, D.
A1  - Di Girolamo, T.
A1  - Di Giulio, C.
A1  - Di Pierro, F.
A1  - Di Venere, L.
A1  - Doro, M.
A1  - Dournaux, J.
A1  - Dumas, D.
A1  - Dwarkadas, Vikram V.
A1  - Diaz, C.
A1  - Ebr, J.
A1  - Egberts, Kathrin
A1  - Einecke, S.
A1  - Elsaesser, D.
A1  - Eschbach, S.
A1  - Falceta-Goncalves, D.
A1  - Fasola, G.
A1  - Fedorova, E.
A1  - Fernandez-Barral, A.
A1  - Ferrand, Gilles
A1  - Fesquet, M.
A1  - Fiandrini, E.
A1  - Fiasson, A.
A1  - Filipovic, Miroslav D.
A1  - Fioretti, V.
A1  - Font, L.
A1  - Fontaine, Gilles
A1  - Franco, F. J.
A1  - Freixas Coromina, L.
A1  - Fujita, Yutaka
A1  - Fukui, Y.
A1  - Funk, S.
A1  - Forster, A.
A1  - Gadola, A.
A1  - Lopez, R. Garcia
A1  - Garczarczyk, M.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giuliani, A.
A1  - Glicenstein, J.
A1  - Gnatyk, R.
A1  - Goldoni, P.
A1  - Grabarczyk, T.
A1  - Graciani, R.
A1  - Graham, J.
A1  - Grandi, P.
A1  - Granot, Jonathan
A1  - Green, A. J.
A1  - Griffiths, S.
A1  - Gunji, S.
A1  - Hakobyan, H.
A1  - Hara, S.
A1  - Hassan, T.
A1  - Hayashida, M.
A1  - Heller, M.
A1  - Helo, J. C.
A1  - Hinton, J.
A1  - Hnatyk, B.
A1  - Huet, J.
A1  - Huetten, M.
A1  - Humensky, T. B.
A1  - Hussein, M.
A1  - Horandel, J.
A1  - Ikeno, Y.
A1  - Inada, T.
A1  - Inome, Y.
A1  - Inoue, S.
A1  - Inoue, T.
A1  - Inoue, Y.
A1  - Ioka, K.
A1  - Iori, Maurizio
A1  - Jacquemier, J.
A1  - Janecek, P.
A1  - Jankowsky, D.
A1  - Jung, I.
A1  - Kaaret, P.
A1  - Katagiri, H.
A1  - Kimeswenger, S.
A1  - Kimura, Shigeo S.
A1  - Knodlseder, J.
A1  - Koch, B.
A1  - Kocot, J.
A1  - Kohri, K.
A1  - Komin, N.
A1  - Konno, Y.
A1  - Kosack, K.
A1  - Koyama, S.
A1  - Kraus, Michaela
A1  - Kubo, Hidetoshi
A1  - Mezek, G. Kukec
A1  - Kushida, J.
A1  - La Palombara, N.
A1  - Lalik, K.
A1  - Lamanna, G.
A1  - Landt, H.
A1  - Lapington, J.
A1  - Laporte, P.
A1  - Lee, S.
A1  - Lees, J.
A1  - Lefaucheur, J.
A1  - Lenain, J. -P.
A1  - Leto, Giuseppe
A1  - Lindfors, E.
A1  - Lohse, T.
A1  - Lombardi, S.
A1  - Longo, F.
A1  - Lopez, M.
A1  - Lucarelli, F.
A1  - Luque-Escamilla, Pedro Luis
A1  - Lopez-Coto, R.
A1  - Maccarone, M. C.
A1  - Maier, G.
A1  - Malaguti, G.
A1  - Mandat, D.
A1  - Maneva, G.
A1  - Mangano, S.
A1  - Marcowith, Alexandre
A1  - Marti, J.
A1  - Martinez, M.
A1  - Martinez, G.
A1  - Masuda, S.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Melioli, Claudio
A1  - Mineo, T.
A1  - Mirabal, N.
A1  - Mizuno, T.
A1  - Moderski, R.
A1  - Mohammed, M.
A1  - Montaruli, T.
A1  - Moralejo, A.
A1  - Mori, K.
A1  - Morlino, G.
A1  - Morselli, A.
A1  - Moulin, Emmanuel
A1  - Mukherjee, R.
A1  - Mundell, C.
A1  - Muraishi, H.
A1  - Murase, Kohta
A1  - Nagataki, Shigehiro
A1  - Nagayoshi, T.
A1  - Naito, T.
A1  - Nakajima, D.
A1  - Nakamori, T.
A1  - Nemmen, R.
A1  - Niemiec, Jacek
A1  - Nieto, D.
A1  - Nievas-Rosillo, M.
A1  - Nikolajuk, M.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Nosek, D.
A1  - Novosyadlyj, B.
A1  - Nozaki, S.
A1  - Ohira, Yutaka
A1  - Ohishi, M.
A1  - Ohm, S.
A1  - Okumura, A.
A1  - Ong, R. A.
A1  - Orito, R.
A1  - Orlati, A.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, Marco
A1  - Palacio, J.
A1  - Palatka, M.
A1  - Paredes, Josep M.
A1  - Pavy, S.
A1  - Persic, M.
A1  - Petrucci, P.
A1  - Petruk, Oleh
A1  - Pisarski, A.
A1  - Pohl, Martin
A1  - Porcelli, A.
A1  - Prandini, E.
A1  - Prast, J.
A1  - Principe, G.
A1  - Prouza, M.
A1  - Pueschel, Elisa
A1  - Puelhofer, G.
A1  - Quirrenbach, A.
A1  - Rameez, M.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Rizi, V.
A1  - Rodriguez, J.
A1  - Fernandez, G. Rodriguez
A1  - Rodriguez Vazquez, J. J.
A1  - Romano, Patrizia
A1  - Romeo, G.
A1  - Rosado, J.
A1  - Rousselle, J.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Sadeh, I.
A1  - Safi-Harb, S.
A1  - Saito, T.
A1  - Sakaki, N.
A1  - Sanchez, D.
A1  - Sangiorgi, P.
A1  - Sano, H.
A1  - Santander, M.
A1  - Sarkar, S.
A1  - Sawada, M.
A1  - Schioppa, E. J.
A1  - Schoorlemmer, H.
A1  - Schovanek, P.
A1  - Schussler, F.
A1  - Sergijenko, O.
A1  - Servillat, M.
A1  - Shalchi, A.
A1  - Shellard, R. C.
A1  - Siejkowski, H.
A1  - Sillanpaa, A.
A1  - Simone, D.
A1  - Sliusar, V.
A1  - Sol, H.
A1  - Stanic, S.
A1  - Starling, R.
A1  - Stawarz, L.
A1  - Stefanik, S.
A1  - Stephan, M.
A1  - Stolarczyk, T.
A1  - Szanecki, M.
A1  - Szepieniec, T.
A1  - Tagliaferri, G.
A1  - Tajima, H.
A1  - Takahashi, M.
A1  - Takeda, J.
A1  - Tanaka, M.
A1  - Tanaka, S.
A1  - Tejedor, L. A.
A1  - Telezhinsky, Igor O.
A1  - Temnikov, P.
A1  - Terada, Y.
A1  - Tescaro, D.
A1  - Teshima, M.
A1  - Testa, V.
A1  - Thoudam, S.
A1  - Tokanai, F.
A1  - Torres, D. F.
A1  - Torresi, E.
A1  - Tosti, G.
A1  - Townsley, C.
A1  - Travnicek, P.
A1  - Trichard, C.
A1  - Trifoglio, M.
A1  - Tsujimoto, S.
A1  - Vagelli, V.
A1  - Vallania, P.
A1  - Valore, L.
A1  - van Driel, W.
A1  - van Eldik, C.
A1  - Vandenbroucke, Justin
A1  - Vassiliev, V.
A1  - Vecchi, M.
A1  - Vercellone, Stefano
A1  - Vergani, S.
A1  - Vigorito, C.
A1  - Vorobiov, S.
A1  - Vrastil, M.
A1  - Vazquez Acosta, M. L.
A1  - Wagner, S. J.
A1  - Wagner, R.
A1  - Wakely, S. P.
A1  - Walter, R.
A1  - Ward, J. E.
A1  - Watson, J. J.
A1  - Weinstein, A.
A1  - White, M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wilcox, P.
A1  - Williams, D. A.
A1  - Wischnewski, R.
A1  - Wojcik, P.
A1  - Yamamoto, T.
A1  - Yamamoto, H.
A1  - Yamazaki, Ryo
A1  - Yanagita, S.
A1  - Yang, L.
A1  - Yoshida, T.
A1  - Yoshida, M.
A1  - Yoshiike, S.
A1  - Yoshikoshi, T.
A1  - Zacharias, M.
A1  - Zampieri, L.
A1  - Zanin, R.
A1  - Zavrtanik, M.
A1  - Zavrtanik, D.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zechlin, Hannes
A1  - Zhdanov, V.
A1  - Ziegler, A.
A1  - Zorn, J.
T1  - Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.
KW  - cosmic rays
KW  - gamma rays: ISM
KW  - ISM: individual objects (RX J1713.7-3946, G347.3-0.5)
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/aa6d67
SN  - 0004-637X
SN  - 1538-4357
VL  - 840
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Aharonian, Felix A.
A1  - Ait Benkhali, Faical
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Arrieta, M.
A1  - Backes, Michael
A1  - Barnard, M.
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, D.
A1  - Bernhard, S.
A1  - Bernlöhr, Konrad
A1  - Blackwell, R.
A1  - Böttcher, Markus
A1  - Boisson, C.
A1  - Bolmont, Julien
A1  - Bonnefoy, S.
A1  - Bordas, Pol
A1  - Bregeon, J.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Büchele, M.
A1  - Bulik, Tomasz
A1  - Bylund, Tomas
A1  - Capasso, Massimo
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Cerruti, Matteo
A1  - Chakraborty, Nachiketa
A1  - Chandra, S.
A1  - Chaves, R. C. G.
A1  - Chen, A.
A1  - Colafrancesco, Sergio
A1  - Condon, B.
A1  - Davids, Isak
A1  - Deil, Christoph
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, Axel
A1  - Doroshenko, Victor
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Emery, G.
A1  - Ernenwein, J. -P.
A1  - Eschbach, Stefan
A1  - Fegan, S.
A1  - Fiasson, Armand
A1  - Fontaine, G.
A1  - Funk, Sebastian
A1  - Füßling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Gate, F.
A1  - Giavitto, Gianluca
A1  - Eisenacher Glawion, Dorit
A1  - Glicenstein, Jean-François
A1  - Gottschall, D.
A1  - Grondin, Marie-Hélène
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Heinzelmann, G.
A1  - Henri, Gilles
A1  - Hermann, G.
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hoischen, Clemens
A1  - Holch, Tim Lukas
A1  - Holler, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Iwasaki, H.
A1  - Jacholkowska, A.
A1  - Jamrozy, M.
A1  - Jankowsky, David
A1  - Jankowsky, Felix
A1  - Jouvin, L.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzyński, Krzysztof
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Kerszberg, D.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, M.
A1  - Kruger, P. P.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lefaucheur, J.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, T.
A1  - Lorentz, M.
A1  - Lopez-Coto, R.
A1  - Lypova, I.
A1  - Malyshev, D.
A1  - Marandon, V.
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, M.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Perennes, C.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V.
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V.
A1  - Saito, S.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schussler, F.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shilon, I.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Specovius, A.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steppa, Constantin Beverly
A1  - Takahashi, T.
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tibaldo, L.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Yang, R.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zywucka, N.
A1  - Cirelli, M.
A1  - Panci, P.
A1  - Sala, F.
A1  - Silk, J.
A1  - Taoso, M.
T1  - Searches for gamma-ray lines and 'pure WIMP' spectra from Dark Matter annihilations in dwarf galaxies with H.E.S.S.
JF  - Journal of cosmology and astroparticle physics
N2  - Dwarf spheroidal galaxies are among the most promising targets for detecting signals of Dark Matter (DM) annihilations. The H.E.S.S. experiment has observed five of these systems for a total of about 130 hours. The data are re-analyzed here, and, in the absence of any detected signals, are interpreted in terms of limits on the DM annihilation cross section. Two scenarios are considered: i) DM annihilation into mono-energetic gamma-rays and ii) DM in the form of pure WIMP multiplets that, annihilating into all electroweak bosons, produce a distinctive gamma-ray spectral shape with a high-energy peak at the DM mass and a lower-energy continuum. For case i), upper limits at 95% confidence level of about <sigma upsilon > less than or similar to 3 x 10(-25) cm(3) s(-1) are obtained in the mass range of 400 GeV to 1TeV. For case ii), the full spectral shape of the models is used and several excluded regions are identified, but the thermal masses of the candidates are not robustly ruled out.
KW  - dark matter detectors
KW  - dark matter experiments
KW  - dwarfs galaxies
KW  - gamma ray detectors
Y1  - 2018
U6  - https://doi.org/10.1088/1475-7516/2018/11/037
SN  - 1475-7516
IS  - 11
PB  - IOP Publishing Ltd. (Bristol)
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faiçal Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arrieta, M.
A1  - Aubert, Pierre
A1  - Backes, Michael
A1  - Balzer, Arnim
A1  - Barnard, Michelle
A1  - Becherini, Yvonne
A1  - Tjus, Julia Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Blackwell, R.
A1  - Bottcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Capasso, M.
A1  - Carr, John
A1  - Casanova, Sabrina
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chen, Andrew
A1  - Chevalier, J.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Condon, B.
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, Christoph
A1  - deWilt, P.
A1  - Djannati-Atai, Arache
A1  - Domainko, Wilfried
A1  - Donath, Axel
A1  - Dubus, Guillaume
A1  - Dutson, Kate
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Ernenwein, J. -P.
A1  - Eschbach, S.
A1  - Farnier, C.
A1  - Fegan, Stuart
A1  - Fernandes, M. V.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Funk, S.
A1  - Füßling, Matthias
A1  - Gabici, Stefano
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, Gianluca
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, Daniel
A1  - Goyal, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, Daniela
A1  - Hahn, J.
A1  - Hawkes, J.
A1  - Heinzelmann, G.
A1  - Henri, Gilles
A1  - Hermann, G.
A1  - Hervet, Olivier
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, Werner
A1  - Hoischen, Clemens
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, Alex
A1  - Jacholkowska, A.
A1  - Jamrozy, Marek
A1  - Janiak, M.
A1  - Jankowsky, D.
A1  - Jankowsky, Felix
A1  - Jingo, M.
A1  - Jogler, Tobias
A1  - Jouvin, Lea
A1  - Jung-Richardt, Ira
A1  - Kastendieck, M. A.
A1  - Katarzynski, Krzysztof
A1  - Katz, Uli
A1  - Kerszberg, D.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - King, J.
A1  - Klepser, S.
A1  - Klochkov, Dmitry
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Kraus, Michael
A1  - Krayzel, F.
A1  - Kruger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lau, Jeanie
A1  - Lees, J. -P.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Leser, Eva
A1  - Lohse, Thomas
A1  - Lorentz, M.
A1  - Lui, R.
A1  - Lypova, Iryna
A1  - Marandon, Vincent
A1  - Marcowith, Alexandre
A1  - Mariaud, C.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, Michael
A1  - Meintjes, Petrus Johannes
A1  - Menzler, U.
A1  - Meyer, Manuel
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - de Naurois, Mathieu
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, Hirokazu
A1  - Ohm, Stefan
A1  - Oettl, S.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Padovani, Marco
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, Helen
A1  - Prokhorov, Dmitry
A1  - Prokoph, Heike
A1  - Puehlhofer, Gerd
A1  - Punch, Michael
A1  - Quirrenbach, Andreas
A1  - Raab, S.
A1  - Reimer, Anita
A1  - Reimer, Olaf
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, Frank
A1  - Romoli, Carlo
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, David
A1  - Sanchez, David A.
A1  - Santangelo, Andrea
A1  - Sasaki, Manami
A1  - Schlickeiser, Reinhard
A1  - Schussler, F.
A1  - Schulz, Andreas
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Simoni, R.
A1  - Sol, H.
A1  - Spanier, Felix
A1  - Spengler, G.
A1  - Spiess, F.
A1  - Stawarz, Lukasz
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, Martin
A1  - Trichard, C.
A1  - Tuffs, R.
A1  - van der Walt, Johan
A1  - van Eldik, Christopher
A1  - van Soelen, Brian
A1  - Vasileiadis, Georges
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, Jacco
A1  - Voisin, F.
A1  - Voelk, Heinrich J.
A1  - Vuillaume, Thomas
A1  - Wadiasingh, Z.
A1  - Wagner, Stefan J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - White, R.
A1  - Wierzcholska, Alicja
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, Denis
A1  - Yang, R.
A1  - Zabalza, Victor
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Andreas
A1  - Zefi, F.
A1  - Ziegler, A.
A1  - Zywucka, Natalia
T1  - Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS
JF  - Physical review letters
N2  - The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevLett.117.111301
SN  - 0031-9007
SN  - 1079-7114
VL  - 117
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - GEN
A1  - Send, T. S.
A1  - Gilles, M.
A1  - Codd, V.
A1  - Wolf, I. A. C.
A1  - Bardtke, S.
A1  - Streit, Fabian
A1  - Strohmaier, Jana
A1  - Frank, Josef
A1  - Schendel, D.
A1  - Sutterlin, M. W.
A1  - Denniff, M.
A1  - Laucht, Manfred
A1  - Samani, N. J.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
A1  - Witt, Stephanie H.
T1  - Telomere length in newborns is related to maternal stress during pregnancy Response
T2  - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
KW  - Predictive markers
KW  - Risk factors
Y1  - 2018
U6  - https://doi.org/10.1038/s41386-018-0079-8
SN  - 0893-133X
SN  - 1740-634X
VL  - 43
IS  - 11
SP  - 2164
EP  - 2164
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Witt, Stephanie H.
A1  - Frank, Josef
A1  - Gilles, Maria
A1  - Lang, Maren
A1  - Treutlein, Jens
A1  - Streit, Fabian
A1  - Wolf, Isabell A. C.
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Send, Tabea S.
A1  - Heilmann-Heimbach, Stefanie
A1  - Sivalingam, Sugirthan
A1  - Dukal, Helene
A1  - Strohmaier, Jana
A1  - Sütterlin, Marc
A1  - Arloth, Janine
A1  - Laucht, Manfred
A1  - Nöthen, Markus M.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
T1  - Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation
JF  - BMC genomics
N2  - Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels. Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females. Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top "smoking methylation pattern" genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns. Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight.
KW  - DNA methylation
KW  - Smoking
KW  - Birth weight
KW  - Mediation analysis
Y1  - 2018
U6  - https://doi.org/10.1186/s12864-018-4652-7
SN  - 1471-2164
VL  - 19
PB  - BMC
CY  - London
ER  - 
TY  - JOUR
A1  - Send, Tabea
A1  - Bardtke, S.
A1  - Gilles, M.
A1  - Wolf, I. A. C.
A1  - Sütterlin, Marc Wolf
A1  - Wudy, S. A.
A1  - Wang, R.
A1  - Laucht, Manfred
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Streit, Fabian
A1  - Deuschle, Michael
T1  - Prenatal maternal stress is associated with lower cortisol and cortisone levels in the first morning urine of 45-month-old children
JF  - Psychoneuroendocrinology
N2  - Prenatal stress (PS) has been related to altered hypothalamic-pituitary-adrenal (HPA) axis activity later in life. So far, studies in children assessing HPA axis functioning have focused on salivary cortisol, reflecting daytime activity. The present work is part of a prospective study and aims to extend knowledge about the association between PS and HPA axis regulation in children. To do so, we investigated cortisol, cortisone, and the ratio cortisone/(cortisone + cortisol) in the first morning urine of 45-month-old children in relation to several measures of maternal stress during pregnancy. Urinary cortisol and cortisone were measured by online turbulent flow chromatography coupled with high performance liquid chromatography-tandem mass spectrometry. PS was defined as: perceived stress for aim 1 (Perceived Stress Scale; n = 280); presence of self-reported (n = 371) and expert-rated psychopathology for aim 2 (Mini International Neuropsychiatric Interview; n = 281); continuous measures of anxiety and depression for exploratory aim 3 (State-Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale; n = 280). The ratio cortisone/(cortisone + cortisol) as a global marker for the balance between the enzymes metabolizing cortisol to cortisone and vice versa (11 beta-hydroxysteroid dehydrogenases type 1 and 2; 11 beta-HSD1 and 2) was not associated with any measure of maternal PS (aims 1-3). The present study provides insight into possible programming effects of PS on nocturnal HPA axis activity and a proxy of 11 beta-HSD in a large sample. The results suggest that the nocturnal rate of cortisol production is lower in children exposed to PS, but do not support the hypothesis of divergent 11 beta-HSD activity.
KW  - Prenatal stress
KW  - Cortisol
KW  - Cortisone
KW  - HPA axis
KW  - Perceived stress
KW  - Psychopathology
Y1  - 2019
U6  - https://doi.org/10.1016/j.psyneuen.2019.01.017
SN  - 0306-4530
VL  - 103
SP  - 219
EP  - 224
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Mieth, Bettina
A1  - Kloft, Marius
A1  - Rodriguez, Juan Antonio
A1  - Sonnenburg, Soren
A1  - Vobruba, Robin
A1  - Morcillo-Suarez, Carlos
A1  - Farre, Xavier
A1  - Marigorta, Urko M.
A1  - Fehr, Ernst
A1  - Dickhaus, Thorsten
A1  - Blanchard, Gilles
A1  - Schunk, Daniel
A1  - Navarro, Arcadi
A1  - Müller, Klaus-Robert
T1  - Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies
JF  - Scientific reports
N2  - The standard approach to the analysis of genome-wide association studies (GWAS) is based on testing each position in the genome individually for statistical significance of its association with the phenotype under investigation. To improve the analysis of GWAS, we propose a combination of machine learning and statistical testing that takes correlation structures within the set of SNPs under investigation in a mathematically well-controlled manner into account. The novel two-step algorithm, COMBI, first trains a support vector machine to determine a subset of candidate SNPs and then performs hypothesis tests for these SNPs together with an adequate threshold correction. Applying COMBI to data from a WTCCC study (2007) and measuring performance as replication by independent GWAS published within the 2008-2015 period, we show that our method outperforms ordinary raw p-value thresholding as well as other state-of-the-art methods. COMBI presents higher power and precision than the examined alternatives while yielding fewer false (i.e. non-replicated) and more true (i.e. replicated) discoveries when its results are validated on later GWAS studies. More than 80% of the discoveries made by COMBI upon WTCCC data have been validated by independent studies. Implementations of the COMBI method are available as a part of the GWASpi toolbox 2.0.
Y1  - 2016
U6  - https://doi.org/10.1038/srep36671
SN  - 2045-2322
VL  - 6
PB  - Nature Publ. Group
CY  - London
ER  -