TY - CHAP A1 - Borowski, Andreas A1 - Glowinski, Ingrid A1 - Frister, Jonas A1 - Höttecke, Dietmar A1 - Buth, Katrin A1 - Koenen, Jenna A1 - Masanek, Nicole A1 - Reichwein, Wilko A1 - Scholten, Nina A1 - Sprenger, Sandra A1 - Stender, Peter A1 - Wöhlke, Carina A1 - Komorek, Michael A1 - Freckmann, Janine A1 - Hofmann, Josefine A1 - Niesel, Verena A1 - Richter, Chris A1 - Mehlmann, Nelli A1 - Bikner-Ahsbahs, Angelika A1 - Unverricht, Katja A1 - Schanze, Sascha A1 - Bittorf, Robert Marten A1 - Meier, Monique A1 - Grospietsch, Finja A1 - Mayer, Jürgen A1 - Gimbel, Katharina A1 - Ziepprecht, Kathrin A1 - Hofmann, Judith A1 - Kramer, Charlotte A1 - Müller, Britta-Kornelia A1 - Rohde, Andreas A1 - Zühlsdorf, Felix A1 - Winkler, Iris A1 - Laging, Ralf A1 - Peter, Carina A1 - Schween, Michael A1 - Härle, Gerhard A1 - Busse, Beatrix A1 - Mahner, Sebastian A1 - Köstler, Verena A1 - Kufner, Sabrina A1 - Mägdefrau, Jutta A1 - Müller, Christian A1 - Beck, Christina A1 - Kriehuber, Eva A1 - Boch, Florian A1 - Engl, Anna-Teresa A1 - Helzel, Andreas A1 - Pickert, Tina A1 - Reiter, Christian A1 - Blasini, Bettina A1 - Nerdel, Claudia A1 - Lewalter, Doris A1 - Schiffhauer, Silke A1 - Richter-Gebert, Jürgen A1 - Bannert, Maria A1 - Maahs, Mirjam A1 - Reißner, Maria A1 - Ungar, Patrizia A1 - von Wachter, Jana-Kristin A1 - Hellmann, Katharina A1 - Zaki, Katja A1 - Pohlenz, Philipp ED - Glowinski, Ingrid ED - Borowski, Andreas ED - Gillen, Julia ED - Schanze, Sascha ED - von Meien, Joachim T1 - Kohärenz in der universitären Lehrerbildung T1 - Coherence in teacher education at university BT - Vernetzung von Fachwissenschaft, Fachdidaktik und Bildungswissenschaften BT - linking studies in content knowledge, pedagogical content knowledge and pedagogical knowledge in teacher education N2 - One area that is supported by the project “Qualitätsoffensive Lehrerbildung” (funded by BMBF) is the improvement of collaboration and coordination between studies in the discipline, studies in pedagogical content knowledge, and studies in pedagogical knowledge during teacher education at university. Aiming a better coordination among these three parts of teacher education at university, many of the supported projects have designed and realized university-specific approaches. This conference proceedings volume comprises contributions by 15 of these projects. Seven of those were introduced and discussed in workshops on the occasion of two cross-regional project-conferences in Hannover and Potsdam. Overall, the contributions give a theoretically funded as well as a practice-oriented overview of current approaches and concepts to achieve a better connection between study units concerning studies in content knowledge, pedagogical content knowledge and pedagogical knowledge in teacher education. The volume presents university projects, which take effect on different levels (at the level of curriculum and content, at a collegiate level, at the level of structural conditions of universities). The different approaches are described in a way that they can provide a basis for transfer to other subjects or further universities. The contributions are aimed at teacher educators as well as other actors working in the field of teaching- and quality development at universities. All of them can take transferable ideas and impulses from the described concepts and formats. N2 - Eine verbesserte Zusammenarbeit und Abstimmung von Fachwissenschaft, Fachdidaktik, Bildungswissenschaften und schulpraktischen Lernorten ist einer der Förderbereiche der „Qualitätsoffensive Lehrerbildung“. Zahlreiche der geförderten Projekte haben für dieses Handlungsfeld im Bereich Vernetzung von Fachwissenschaft, Fachdidaktik und Bildungswissenschaften hochschulspezifische Maßnahmen konzipiert und umgesetzt. Der vorliegende Tagungsband beinhaltet Beiträge von 15 entsprechenden Projekten, von denen sieben anlässlich von zwei standortübergreifenden Projekt-Tagungen in Hannover und Potsdam vorgestellt und in Workshops diskutiert wurden. Insgesamt geben die Beiträge einen theoretisch fundierten und gleichzeitig praxisorientierten Überblick über aktuelle Ansätze und Konzepte zur besseren Vernetzung fachwissenschaftlicher, fachdidaktischer und bildungswissenschaftlicher Studienanteile im Lehramtsstudium. Dargestellt werden Projektarbeiten der Hochschulen, die auf verschiedenen Ebenen wirksam werden (curricular-inhaltliche Ebene, kollegiale Ebene, hochschul-strukturelle Ebene). Die Maßnahmen sind so beschrieben, dass sie als Grundlage für einen Transfer auf andere Fächer bzw. andere Standorte genutzt werden können. Die Beiträge richten sich an alle Lehrenden im Bereich der Lehramtsbildung sowie sonstige Akteure im Bereich der Lehr- und Qualitätsentwicklung an den Universitäten. Sie alle können den beschriebenen Konzepten und Umsetzungsformaten transferierbare Ideen und Impulse entnehmen. KW - Professionswissen KW - universitäre Lehrerbildung KW - Vernetzung Fachwissenschaft KW - Fachdidaktik KW - Bildungswissenschaft KW - Lehramtsstudium KW - teacher education KW - professional knowledge KW - content knowledge KW - pedagogical content knowledge Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414267 SN - 978-3-86956-438-8 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Riedel, Simona A1 - Siemiatkowska, Beata A1 - Watanabe, Mutsumi A1 - Müller, Christina S. A1 - Schünemann, Volker A1 - Hoefgen, Rainer A1 - Leimkühler, Silke T1 - The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - The mitochondrial ATP-binding cassette (ABC) transporters ABCB7 in humans, Atm1 in yeast and ATM3 in plants, are highly conserved in their overall architecture and particularly in their glutathione binding pocket located within the transmembrane spanning domains. These transporters have attracted interest in the last two decades based on their proposed role in connecting the mitochondrial iron sulfur (Fe–S) cluster assembly with its cytosolic Fe–S cluster assembly (CIA) counterpart. So far, the specific compound that is transported across the membrane remains unknown. In this report we characterized the ABCB7-like transporter Rcc02305 in Rhodobacter capsulatus, which shares 47% amino acid sequence identity with its mitochondrial counterpart. The constructed interposon mutant strain in R. capsulatus displayed increased levels of intracellular reactive oxygen species without a simultaneous accumulation of the cellular iron levels. The inhibition of endogenous glutathione biosynthesis resulted in an increase of total glutathione levels in the mutant strain. Bioinformatic analysis of the amino acid sequence motifs revealed a potential aminotransferase class-V pyridoxal-50-phosphate (PLP) binding site that overlaps with the Walker A motif within the nucleotide binding domains of the transporter. PLP is a well characterized cofactor of L-cysteine desulfurases like IscS and NFS1 which has a role in the formation of a protein-bound persulfide group within these proteins. We therefore suggest renaming the ABCB7-like transporter Rcc02305 in R. capsulatus to PexA for PLP binding exporter. We further suggest that this ABC-transporter in R. capsulatus is involved in the formation and export of polysulfide species to the periplasm. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 740 KW - ABCB7 KW - persulfide KW - polysulfide KW - glutathione KW - ABC transporter KW - Walker A motif KW - pyridoxal-50-phosphate Y1 - 1019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-434975 SN - 1866-8372 IS - 740 ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Arbeitsheft 1 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 3-425-11121-3 PB - Diesterweg CY - Braunschweig ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Schülerband 3 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 3-425-11133-7 PB - Diesterweg CY - Braunschweig ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Schülerband 4 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 3-425-11056-X PB - Diesterweg CY - Braunschweig ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Arbeitsheft 3 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 978-3-425-11123-0 PB - Diesterweg CY - Braunschweig ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Arbeitsheft 4 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 978-3-425-11066-0 PB - Diesterweg CY - Braunschweig ER - TY - BOOK A1 - Aulke, Gudrun A1 - Brandenburg, Silke A1 - Drechsler-Köhler, Beate A1 - Giest, Hartmut A1 - Haas, Wolfgang A1 - Hinze, Gabriele A1 - Höffer, Ute A1 - Koriller, Astrid A1 - Lüftner, Werner A1 - Müller, Uta A1 - Mues, Rainer A1 - Papstein, Gisela A1 - Schiepe, Axel ED - Giest, Hartmut T1 - Bausteine Sachunterricht : Arbeitsheft 2 ; Berlin / Brandenburg / Mecklenburg-Vorpommern ; Grundschule Y1 - 2005 SN - 978-3-425-11122-3 PB - Diesterweg CY - Braunschweig ER - TY - JOUR A1 - Bartsch, Silke A1 - Bauer, Katharina A1 - Müller, Heike A1 - Penning, Isabelle T1 - Verbraucherkompetenzen für morgen und durch Lehrkräfteweiterbildung heute BT - Professionalisierung von Lehrpersonen in der Verbraucherbildung JF - Haushalt in Bildung und Forschung (HiBiFo) N2 - Verbraucherbildung ist bundesweit vielfältig in curricularen Vorgaben verankert. Fachfremde Lehrpersonen benötigen Professionalisierungsangebote, um die Verbraucherbildung als Querschnittsaufgabe in ihren Fächern implementieren zu können. Erkenntnisse aus der Professionalisierungsforschung werden daher im Beitrag in Bezug auf das cLEVER-Projekt zusammengetragen, um sie für Fortbildungsangebote nutzbar zu machen. N2 - Consumer education is anchored in a variety of curricular guidelines throughout Germany. Teachers from outside the subject area need professionalization offers in order to be able to implement consumer education as a cross-sectional task in their subjects. Findings from professionalization research will, therefore, be compiled in the article relating to the cLEV ER-project to make them usable for further training courses. KW - Verbraucherbildung KW - Consumer Literacy KW - Professionalisierung KW - Lehrerbildung KW - Fortbildung KW - consumer education KW - consumer literacy KW - professionalization KW - eacher training KW - continuing education Y1 - 2019 U6 - https://doi.org/10.3224/hibifo.v8i4.06 SN - 2193-8806 SN - 2196-1662 VL - 8 IS - 4 SP - 90 EP - 103 PB - Budrich CY - Leverkusen ER - TY - JOUR A1 - Müller, Silke A1 - Rawel, Harshadrai Manilal A1 - Muschiolik, Gerald T1 - Surface activity of modified soy proteins Y1 - 1995 ER - TY - JOUR A1 - Mikelskis, Helmut A1 - Müller, Wieland A1 - Seifert, Silke T1 - Grenzüberschreitungen im Physikunterricht : Lernen in der Dialektik von Disziplinarität und Interdisziplinarität Y1 - 1998 ER - TY - JOUR A1 - Riedel, Simona A1 - Siemiatkowska, Beata A1 - Watanabe, Mutsumi A1 - Müller, Christina S. A1 - Schünemann, Volker A1 - Hoefgen, Rainer A1 - Leimkühler, Silke T1 - The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species JF - Frontiers in Microbiology N2 - The mitochondrial ATP-binding cassette (ABC) transporters ABCB7 in humans, Atm1 in yeast and ATM3 in plants, are highly conserved in their overall architecture and particularly in their glutathione binding pocket located within the transmembrane spanning domains. These transporters have attracted interest in the last two decades based on their proposed role in connecting the mitochondrial iron sulfur (Fe–S) cluster assembly with its cytosolic Fe–S cluster assembly (CIA) counterpart. So far, the specific compound that is transported across the membrane remains unknown. In this report we characterized the ABCB7-like transporter Rcc02305 in Rhodobacter capsulatus, which shares 47% amino acid sequence identity with its mitochondrial counterpart. The constructed interposon mutant strain in R. capsulatus displayed increased levels of intracellular reactive oxygen species without a simultaneous accumulation of the cellular iron levels. The inhibition of endogenous glutathione biosynthesis resulted in an increase of total glutathione levels in the mutant strain. Bioinformatic analysis of the amino acid sequence motifs revealed a potential aminotransferase class-V pyridoxal-50-phosphate (PLP) binding site that overlaps with the Walker A motif within the nucleotide binding domains of the transporter. PLP is a well characterized cofactor of L-cysteine desulfurases like IscS and NFS1 which has a role in the formation of a protein-bound persulfide group within these proteins. We therefore suggest renaming the ABCB7-like transporter Rcc02305 in R. capsulatus to PexA for PLP binding exporter. We further suggest that this ABC-transporter in R. capsulatus is involved in the formation and export of polysulfide species to the periplasm. KW - ABCB7 KW - persulfide KW - polysulfide KW - glutathione KW - ABC transporter KW - Walker A motif KW - pyridoxal-50-phosphate Y1 - 2019 U6 - https://doi.org/10.3389/fmicb.2019.00406 SN - 1664-302X VL - 10 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Hasnat, Muhammad Abrar A1 - Zupok, Arkadiusz A1 - Olas-Apelt, Justyna Jadwiga A1 - Müller-Röber, Bernd A1 - Leimkühler, Silke T1 - A-type carrier proteins are involved in [4Fe-4S] cluster insertion into the radical S-adenosylmethionine protein MoaA for the synthesis of active molybdoenzymes JF - Journal of bacteriology N2 - Iron sulfur (Fe-S) clusters are important biological cofactors present in proteins with crucial biological functions, from photosynthesis to DNA repair, gene expression, and bioenergetic processes. For the insertion of Fe-S clusters into proteins, A-type carrier proteins have been identified. So far, three of them have been characterized in detail in Escherichia coli, namely, IscA, SufA, and ErpA, which were shown to partially replace each other in their roles in [4Fe-4S] cluster insertion into specific target proteins. To further expand the knowledge of [4Fe-4S] cluster insertion into proteins, we analyzed the complex Fe-S cluster-dependent network for the synthesis of the molybdenum cofactor (Moco) and the expression of genes encoding nitrate reductase in E. coli. Our studies include the identification of the A-type carrier proteins ErpA and IscA, involved in [4Fe-4S] cluster insertion into the radical Sadenosyl-methionine (SAM) enzyme MoaA. We show that ErpA and IscA can partially replace each other in their role to provide [4Fe-4S] clusters for MoaA. Since most genes expressing molybdoenzymes are regulated by the transcriptional regulator for fumarate and nitrate reduction (FNR) under anaerobic conditions, we also identified the proteins that are crucial to obtain an active FNR under conditions of nitrate respiration. We show that ErpA is essential for the FNR-dependent expression of the narGHJI operon, a role that cannot be compensated by IscA under the growth conditions tested. SufA does not appear to have a role in Fe-S cluster insertion into MoaA or FNR under anaerobic growth employing nitrate respiration, based on the low level of gene expression.
IMPORTANCE Understanding the assembly of iron-sulfur (Fe-S) proteins is relevant to many fields, including nitrogen fixation, photosynthesis, bioenergetics, and gene regulation. Remaining critical gaps in our knowledge include how Fe-S clusters are transferred to their target proteins and how the specificity in this process is achieved, since different forms of Fe-S clusters need to be delivered to structurally highly diverse target proteins. Numerous Fe-S carrier proteins have been identified in prokaryotes like Escherichia coli, including ErpA, IscA, SufA, and NfuA. In addition, the diverse Fe-S cluster delivery proteins and their target proteins underlie a complex regulatory network of expression, to ensure that both proteins are synthesized under particular growth conditions. KW - iron-sulfur clusters KW - Moco biosynthesis KW - MoaA KW - A-type carrier protein KW - FNR KW - nitrate reductase KW - molybdenum cofactor Y1 - 2021 U6 - https://doi.org/10.1128/JB.00086-21 SN - 1098-5530 VL - 203 IS - 12 PB - American Society for Microbiology CY - Washington ER - TY - GEN A1 - Jeltsch, Florian A1 - Bonte, Dries A1 - Pe'er, Guy A1 - Reineking, Björn A1 - Leimgruber, Peter A1 - Balkenhol, Niko A1 - Schröder-Esselbach, Boris A1 - Buchmann, Carsten M. A1 - Müller, Thomas A1 - Blaum, Niels A1 - Zurell, Damaris A1 - Böhning-Gaese, Katrin A1 - Wiegand, Thorsten A1 - Eccard, Jana A1 - Hofer, Heribert A1 - Reeg, Jette A1 - Eggers, Ute A1 - Bauer, Silke T1 - Integrating movement ecology with biodiversity research BT - exploring new avenues to address spatiotemporal biodiversity dynamics N2 - Movement of organisms is one of the key mechanisms shaping biodiversity, e.g. the distribution of genes, individuals and species in space and time. Recent technological and conceptual advances have improved our ability to assess the causes and consequences of individual movement, and led to the emergence of the new field of ‘movement ecology’. Here, we outline how movement ecology can contribute to the broad field of biodiversity research, i.e. the study of processes and patterns of life among and across different scales, from genes to ecosystems, and we propose a conceptual framework linking these hitherto largely separated fields of research. Our framework builds on the concept of movement ecology for individuals, and demonstrates its importance for linking individual organismal movement with biodiversity. First, organismal movements can provide ‘mobile links’ between habitats or ecosystems, thereby connecting resources, genes, and processes among otherwise separate locations. Understanding these mobile links and their impact on biodiversity will be facilitated by movement ecology, because mobile links can be created by different modes of movement (i.e., foraging, dispersal, migration) that relate to different spatiotemporal scales and have differential effects on biodiversity. Second, organismal movements can also mediate coexistence in communities, through ‘equalizing’ and ‘stabilizing’ mechanisms. This novel integrated framework provides a conceptual starting point for a better understanding of biodiversity dynamics in light of individual movement and space-use behavior across spatiotemporal scales. By illustrating this framework with examples, we argue that the integration of movement ecology and biodiversity research will also enhance our ability to conserve diversity at the genetic, species, and ecosystem levels. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 401 KW - mobile links KW - species coexistence KW - community dynamics KW - biodiversity conservation KW - long distance movement KW - landscape genetics KW - individual based modeling Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401177 ER - TY - JOUR A1 - Jeltsch, Florian A1 - Bonte, Dries A1 - Peer, Guy A1 - Reineking, Björn A1 - Leimgruber, Peter A1 - Balkenhol, Niko A1 - Schröder-Esselbach, Boris A1 - Buchmann, Carsten M. A1 - Müller, Thomas A1 - Blaum, Niels A1 - Zurell, Damaris A1 - Böhning-Gaese, Katrin A1 - Wiegand, Thorsten A1 - Eccard, Jana A1 - Hofer, Heribert A1 - Reeg, Jette A1 - Eggers, Ute A1 - Bauer, Silke T1 - Integrating movement ecology with biodiversity research - exploring new avenues to address spatiotemporal biodiversity dynamics Y1 - 2013 UR - http://download.springer.com/static/pdf/827/art%253A10.1186%252F2051-3933-1- 6.pdf?auth66=1394891271_f1a4cb74d6be42ee3f8872ef2ca22c24&ext=.pdf U6 - https://doi.org/10.1186/2051-3933-1-6 ER -