TY - JOUR A1 - Prestel, Andreas A1 - Möller, Heiko Michael T1 - Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides JF - Chemical communications N2 - The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control. Y1 - 2016 U6 - https://doi.org/10.1039/c5cc06848g SN - 1359-7345 SN - 1364-548X VL - 52 SP - 701 EP - 704 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Holert, Johannes A1 - Yücel, Onur A1 - Jagmann, Nina A1 - Prestel, Andreas A1 - Möller, Heiko Michael A1 - Philipp, Bodo T1 - Identification of bypass reactions leading to the formation of one central steroid degradation intermediate in metabolism of different bile salts in Pseudomonas sp strain Chol1 JF - Environmental microbiology Y1 - 2016 U6 - https://doi.org/10.1111/1462-2920.13192 SN - 1462-2912 SN - 1462-2920 VL - 18 SP - 3373 EP - 3389 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Prestel, Andreas A1 - Möller, Heiko Michael T1 - Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides N2 - The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 218 Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-89658 SP - 701 EP - 704 ER - TY - JOUR A1 - Kastl, Johanna A1 - Braun, Joachim A1 - Prestel, Andreas A1 - Möller, Heiko Michael A1 - Huhn, Thomas A1 - Mayer, Thomas U. T1 - Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint JF - ACS chemical biology N2 - The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge, a cellular surveillance mechanism, termed the spindle assembly checkpoint (SAC), evolved that monitors the correct attachment of chromosomes and blocks progression through mitosis if corrections are needed. While the central role of the SAC for genome integrity is well established, its functional dissection has been hampered by the limited availability of appropriate small molecule inhibitors. Using a fluorescence polarization-based screen, we identify Mad2 inhibitor-1 (M2I-1), the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. Based on computational and biochemical analyses, we propose that M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells. Thus, our study identifies the SAC specific complex formation between Mad2 and Cdc20 as a protein-protein interaction that can be targeted by small molecules. Y1 - 2015 U6 - https://doi.org/10.1021/acschembio.5b00121 SN - 1554-8929 SN - 1554-8937 VL - 10 IS - 7 SP - 1661 EP - 1666 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Prestel, Andreas A1 - Möller, Heiko Michael T1 - Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides JF - Chemical communications : ChemComm N2 - The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control. Y1 - 2015 U6 - https://doi.org/10.1039/C5CC06848G SN - 1364-548X IS - 52 SP - 701 EP - 704 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Möller, Andreas A1 - O'Brien, Patrick J. A1 - Kennedy, Allen A1 - Kröner, Alfred T1 - Linking growth episodes of zircon and metamorphic textures to zircon chemistry : an example from the ultra-high temperature granulites of Rogaland (SW Norway) Y1 - 2003 ER - TY - JOUR A1 - Möller, Andreas A1 - O'Brien, Patrick J. A1 - Kennedy, Allen A1 - Kröner, Alfred T1 - Polyphase zircon in ultrahigh-temperature granulites (Rogaland, SW Norway) : constraints for Pb diffusion in zircon N2 - SHRIMP U-Pb ages have been obtained for zircon in granitic gneisses from the aureole of the Rogaland anorthosite-norite intrusive complex, both from the ultrahigh temperature (UHT; >900 °C pigeonite-in) zone and from outside the hypersthene-in isograd. Magmatic and metamorphic segments of composite zircon were characterised on the basis of electron backscattered electron and cathodoluminescence images plus trace element analysis. A sample from outside the UHT zone has magmatic cores with an age of 1034 ± 7 Ma (2{sigma}, n = 8) and 1052 ± 5 Ma (1{sigma}, n = 1) overgrown by M1 metamorphic rims giving ages between 1020 ± 7 and 1007 ± 5 Ma.In contrast, samples from the UHT zone exhibit four major age groups:(1) magmatic cores yielding ages over 1500 Ma(2) magmatic cores giving ages of 1034 ± 13 Ma (2{sigma}, n = 4) and 1056 ± 10 Ma (1{sigma}, n = 1)(3) metamorphic overgrowths ranging in age between 1017 ± 6 Ma and 992 ± 7 Ma (1{sigma}) corresponding to the regional M1 Sveconorwegian granulite facies metamorphism, and(4) overgrowths corresponding to M2 UHT contact metamorphism giving values of 922 ± 14 Ma (2{sigma}, n = 6). Recrystallized areas in zircon from both areas define a further age group at 974 ± 13 Ma (2{sigma}, n = 4).This study presents the first evidence from Rogaland for new growth of zircon resulting from UHT contact metamorphism. More importantly, it shows the survival of magmatic and regional metamorphic zircon relics in rocks that experienced a thermal overprint of c. 950 °C for at least 1 Myr. Magmatic and different metamorphic zones in the same zircon are sharply bounded and preserve original crystallization age information, a result inconsistent with some experimental data on Pb diffusion in zircon which predict measurable Pb diffusion under such conditions. The implication is that resetting of zircon ages by diffusion during M2 was negligible in these dry granulite facies rocks. Imaging and Th/U-Y systematics indicate that the main processes affecting zircon were dissolution-reprecipitation in a closed system and solid-state recrystallization during and soon after M1. Y1 - 2002 ER - TY - JOUR A1 - Möller, Andreas A1 - Nelson, D. R. T1 - Influence of matrix effects on U-Th-Pb dating of monazite by ion microprobe Y1 - 2005 SN - 0016-7037 ER - TY - JOUR A1 - Möller, Andreas T1 - Constraints on age and duration of metamorphic events from in-situ U-Pb dating and geochemical characterization of zircon Y1 - 2005 SN - 0016-7037 ER - TY - JOUR A1 - Möller, Andreas A1 - Hensen, Bastiaan J. A1 - Armstrong, Richard A. A1 - Mezger, Klaus A1 - Ballévre, Michel T1 - U-Pb zircon and monazite age constraints on granulite-facies metamorphism and deformation in the Strangways Metamorphic Complex (central Australia) N2 - The age of Proterozoic granulite facies metamorphism and deformation in the Strangways Metamorphic Complex (SMC) of central Australia is determined on zircon grown in syn-metamorphic and syn-deformational orthopyroxene-bearing, enderbitic, veins. SHRIMP zircon studies suggest that M1-M2 and the correlated periods of intense deformation (D1-D2) are part of a single tectonothermal event between 1,717-2 and 1,732-7 Ma. It is considered unlikely that the two metamorphic phases (M1, M2) suggested by earlier work represent separate events occurring within 10-25 Ma of each other. Previous higher estimates for the age of M1 granulite metamorphism in the SMC (Early Strangways event at ca. 1,770 Ma) based on U-Pb zircon dating of granitic, intrusive rocks, are not believed to relate to the metamorphism, but to represent pre-metamorphic intrusion ages. Conventional multi-grain U-Pb monazite analyses on high-grade metasediments from three widely spaced localities in the western SMC yield 207Pb/235U ages between 1,728-11 and 1,712-2 Ma. The age range of the monazites corresponds to the SHRIMP zircon ages in the granulitic veins and is interpreted to record monazite growth (prograde in the metasedimentary rocks). The data imply a maximum time-span of 30 Ma for high-grade metamorphism and deformation in the SMC. There is, thus, no evidence for an extremely long period of continuous high- temperature conditions from 1,770 to ca. 1,720 Ma as previously proposed. The results firmly establish that the SMC has a very different high-grade metamorphic history than the neighbouring Harts Range, where upper amphibolite facies metamorphism in the Palaeozoic caused widespread growth or recrystallization of monazite. Y1 - 2003 UR - http://www.springerlink.com/app/home/ content.asp?wasp=nnkjymtwwjhb0ylpgw97&referrer=contribution&format=2&page=1&pagecount=18 ER -