TY - JOUR A1 - Dengler, Jürgen A1 - Wagner, Viktoria A1 - Dembicz, Iwona A1 - Garcia-Mijangos, Itziar A1 - Naqinezhad, Alireza A1 - Boch, Steffen A1 - Chiarucci, Alessandro A1 - Conradi, Timo A1 - Filibeck, Goffredo A1 - Guarino, Riccardo A1 - Janisova, Monika A1 - Steinbauer, Manuel J. A1 - Acic, Svetlana A1 - Acosta, Alicia T. R. A1 - Akasaka, Munemitsu A1 - Allers, Marc-Andre A1 - Apostolova, Iva A1 - Axmanova, Irena A1 - Bakan, Branko A1 - Baranova, Alina A1 - Bardy-Durchhalter, Manfred A1 - Bartha, Sandor A1 - Baumann, Esther A1 - Becker, Thomas A1 - Becker, Ute A1 - Belonovskaya, Elena A1 - Bengtsson, Karin A1 - Benito Alonso, Jose Luis A1 - Berastegi, Asun A1 - Bergamini, Ariel A1 - Bonini, Ilaria A1 - Bruun, Hans Henrik A1 - Budzhak, Vasyl A1 - Bueno, Alvaro A1 - Antonio Campos, Juan A1 - Cancellieri, Laura A1 - Carboni, Marta A1 - Chocarro, Cristina A1 - Conti, Luisa A1 - Czarniecka-Wiera, Marta A1 - De Frenne, Pieter A1 - Deak, Balazs A1 - Didukh, Yakiv P. A1 - Diekmann, Martin A1 - Dolnik, Christian A1 - Dupre, Cecilia A1 - Ecker, Klaus A1 - Ermakov, Nikolai A1 - Erschbamer, Brigitta A1 - Escudero, Adrian A1 - Etayo, Javier A1 - Fajmonova, Zuzana A1 - Felde, Vivian A. A1 - Fernandez Calzado, Maria Rosa A1 - Finckh, Manfred A1 - Fotiadis, Georgios A1 - Fracchiolla, Mariano A1 - Ganeva, Anna A1 - Garcia-Magro, Daniel A1 - Gavilan, Rosario G. A1 - Germany, Markus A1 - Giladi, Itamar A1 - Gillet, Francois A1 - Giusso del Galdo, Gian Pietro A1 - Gonzalez, Jose M. A1 - Grytnes, John-Arvid A1 - Hajek, Michal A1 - Hajkova, Petra A1 - Helm, Aveliina A1 - Herrera, Mercedes A1 - Hettenbergerova, Eva A1 - Hobohm, Carsten A1 - Huellbusch, Elisabeth M. A1 - Ingerpuu, Nele A1 - Jandt, Ute A1 - Jeltsch, Florian A1 - Jensen, Kai A1 - Jentsch, Anke A1 - Jeschke, Michael A1 - Jimenez-Alfaro, Borja A1 - Kacki, Zygmunt A1 - Kakinuma, Kaoru A1 - Kapfer, Jutta A1 - Kavgaci, Ali A1 - Kelemen, Andras A1 - Kiehl, Kathrin A1 - Koyama, Asuka A1 - Koyanagi, Tomoyo F. A1 - Kozub, Lukasz A1 - Kuzemko, Anna A1 - Kyrkjeeide, Magni Olsen A1 - Landi, Sara A1 - Langer, Nancy A1 - Lastrucci, Lorenzo A1 - Lazzaro, Lorenzo A1 - Lelli, Chiara A1 - Leps, Jan A1 - Loebel, Swantje A1 - Luzuriaga, Arantzazu L. A1 - Maccherini, Simona A1 - Magnes, Martin A1 - Malicki, Marek A1 - Marceno, Corrado A1 - Mardari, Constantin A1 - Mauchamp, Leslie A1 - May, Felix A1 - Michelsen, Ottar A1 - Mesa, Joaquin Molero A1 - Molnar, Zsolt A1 - Moysiyenko, Ivan Y. A1 - Nakaga, Yuko K. A1 - Natcheva, Rayna A1 - Noroozi, Jalil A1 - Pakeman, Robin J. A1 - Palpurina, Salza A1 - Partel, Meelis A1 - Paetsch, Ricarda A1 - Pauli, Harald A1 - Pedashenko, Hristo A1 - Peet, Robert K. A1 - Pielech, Remigiusz A1 - Pipenbaher, Natasa A1 - Pirini, Chrisoula A1 - Pleskova, Zuzana A1 - Polyakova, Mariya A. A1 - Prentice, Honor C. A1 - Reinecke, Jennifer A1 - Reitalu, Triin A1 - Pilar Rodriguez-Rojo, Maria A1 - Rolecek, Jan A1 - Ronkin, Vladimir A1 - Rosati, Leonardo A1 - Rosen, Ejvind A1 - Ruprecht, Eszter A1 - Rusina, Solvita A1 - Sabovljevic, Marko A1 - Maria Sanchez, Ana A1 - Savchenko, Galina A1 - Schuhmacher, Oliver A1 - Skornik, Sonja A1 - Sperandii, Marta Gaia A1 - Staniaszek-Kik, Monika A1 - Stevanovic-Dajic, Zora A1 - Stock, Marin A1 - Suchrow, Sigrid A1 - Sutcliffe, Laura M. E. A1 - Swacha, Grzegorz A1 - Sykes, Martin A1 - Szabo, Anna A1 - Talebi, Amir A1 - Tanase, Catalin A1 - Terzi, Massimo A1 - Tolgyesi, Csaba A1 - Torca, Marta A1 - Torok, Peter A1 - Tothmeresz, Bela A1 - Tsarevskaya, Nadezda A1 - Tsiripidis, Ioannis A1 - Tzonev, Rossen A1 - Ushimaru, Atushi A1 - Valko, Orsolya A1 - van der Maarel, Eddy A1 - Vanneste, Thomas A1 - Vashenyak, Iuliia A1 - Vassilev, Kiril A1 - Viciani, Daniele A1 - Villar, Luis A1 - Virtanen, Risto A1 - Kosic, Ivana Vitasovic A1 - Wang, Yun A1 - Weiser, Frank A1 - Went, Julia A1 - Wesche, Karsten A1 - White, Hannah A1 - Winkler, Manuela A1 - Zaniewski, Piotr T. A1 - Zhang, Hui A1 - Ziv, Yaron A1 - Znamenskiy, Sergey A1 - Biurrun, Idoia T1 - GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands JF - Phytocoenologia N2 - GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board. KW - biodiversity KW - European Vegetation Archive (EVA) KW - Eurasian Dry Grassland Group (EDGG) KW - grassland vegetation KW - GrassPlot KW - macroecology KW - multi-taxon KW - nested plot KW - scale-dependence KW - species-area relationship (SAR) KW - sPlot KW - vegetation-plot database Y1 - 2018 U6 - https://doi.org/10.1127/phyto/2018/0267 SN - 0340-269X VL - 48 IS - 3 SP - 331 EP - 347 PB - Cramer CY - Stuttgart ER - TY - JOUR A1 - Wuttke, Matthias A1 - Li, Yong A1 - Li, Man A1 - Sieber, Karsten B. A1 - Feitosa, Mary F. A1 - Gorski, Mathias A1 - Tin, Adrienne A1 - Wang, Lihua A1 - Chu, Audrey Y. A1 - Hoppmann, Anselm A1 - Kirsten, Holger A1 - Giri, Ayush A1 - Chai, Jin-Fang A1 - Sveinbjornsson, Gardar A1 - Tayo, Bamidele O. A1 - Nutile, Teresa A1 - Fuchsberger, Christian A1 - Marten, Jonathan A1 - Cocca, Massimiliano A1 - Ghasemi, Sahar A1 - Xu, Yizhe A1 - Horn, Katrin A1 - Noce, Damia A1 - Van der Most, Peter J. A1 - Sedaghat, Sanaz A1 - Yu, Zhi A1 - Akiyama, Masato A1 - Afaq, Saima A1 - Ahluwalia, Tarunveer Singh A1 - Almgren, Peter A1 - Amin, Najaf A1 - Arnlov, Johan A1 - Bakker, Stephan J. L. A1 - Bansal, Nisha A1 - Baptista, Daniela A1 - Bergmann, Sven A1 - Biggs, Mary L. A1 - Biino, Ginevra A1 - Boehnke, Michael A1 - Boerwinkle, Eric A1 - Boissel, Mathilde A1 - Böttinger, Erwin A1 - Boutin, Thibaud S. A1 - Brenner, Hermann A1 - Brumat, Marco A1 - Burkhardt, Ralph A1 - Butterworth, Adam S. A1 - Campana, Eric A1 - Campbell, Archie A1 - Campbell, Harry A1 - Canouil, Mickael A1 - Carroll, Robert J. A1 - Catamo, Eulalia A1 - Chambers, John C. A1 - Chee, Miao-Ling A1 - Chee, Miao-Li A1 - Chen, Xu A1 - Cheng, Ching-Yu A1 - Cheng, Yurong A1 - Christensen, Kaare A1 - Cifkova, Renata A1 - Ciullo, Marina A1 - Concas, Maria Pina A1 - Cook, James P. A1 - Coresh, Josef A1 - Corre, Tanguy A1 - Sala, Cinzia Felicita A1 - Cusi, Daniele A1 - Danesh, John A1 - Daw, E. Warwick A1 - De Borst, Martin H. A1 - De Grandi, Alessandro A1 - De Mutsert, Renee A1 - De Vries, Aiko P. J. A1 - Degenhardt, Frauke A1 - Delgado, Graciela A1 - Demirkan, Ayse A1 - Di Angelantonio, Emanuele A1 - Dittrich, Katalin A1 - Divers, Jasmin A1 - Dorajoo, Rajkumar A1 - Eckardt, Kai-Uwe A1 - Ehret, Georg A1 - Elliott, Paul A1 - Endlich, Karlhans A1 - Evans, Michele K. A1 - Felix, Janine F. A1 - Foo, Valencia Hui Xian A1 - Franco, Oscar H. A1 - Franke, Andre A1 - Freedman, Barry I. A1 - Freitag-Wolf, Sandra A1 - Friedlander, Yechiel A1 - Froguel, Philippe A1 - Gansevoort, Ron T. A1 - Gao, He A1 - Gasparini, Paolo A1 - Gaziano, J. Michael A1 - Giedraitis, Vilmantas A1 - Gieger, Christian A1 - Girotto, Giorgia A1 - Giulianini, Franco A1 - Gogele, Martin A1 - Gordon, Scott D. A1 - Gudbjartsson, Daniel F. A1 - Gudnason, Vilmundur A1 - Haller, Toomas A1 - Hamet, Pavel A1 - Harris, Tamara B. A1 - Hartman, Catharina A. A1 - Hayward, Caroline A1 - Hellwege, Jacklyn N. A1 - Heng, Chew-Kiat A1 - Hicks, Andrew A. A1 - Hofer, Edith A1 - Huang, Wei A1 - Hutri-Kahonen, Nina A1 - Hwang, Shih-Jen A1 - Ikram, M. Arfan A1 - Indridason, Olafur S. A1 - Ingelsson, Erik A1 - Ising, Marcus A1 - Jaddoe, Vincent W. V. A1 - Jakobsdottir, Johanna A1 - Jonas, Jost B. A1 - Joshi, Peter K. A1 - Josyula, Navya Shilpa A1 - Jung, Bettina A1 - Kahonen, Mika A1 - Kamatani, Yoichiro A1 - Kammerer, Candace M. A1 - Kanai, Masahiro A1 - Kastarinen, Mika A1 - Kerr, Shona M. A1 - Khor, Chiea-Chuen A1 - Kiess, Wieland A1 - Kleber, Marcus E. A1 - Koenig, Wolfgang A1 - Kooner, Jaspal S. A1 - Korner, Antje A1 - Kovacs, Peter A1 - Kraja, Aldi T. A1 - Krajcoviechova, Alena A1 - Kramer, Holly A1 - Kramer, Bernhard K. A1 - Kronenberg, Florian A1 - Kubo, Michiaki A1 - Kuhnel, Brigitte A1 - Kuokkanen, Mikko A1 - Kuusisto, Johanna A1 - La Bianca, Martina A1 - Laakso, Markku A1 - Lange, Leslie A. A1 - Langefeld, Carl D. A1 - Lee, Jeannette Jen-Mai A1 - Lehne, Benjamin A1 - Lehtimaki, Terho A1 - Lieb, Wolfgang A1 - Lim, Su-Chi A1 - Lind, Lars A1 - Lindgren, Cecilia M. A1 - Liu, Jun A1 - Liu, Jianjun A1 - Loeffler, Markus A1 - Loos, Ruth J. F. A1 - Lucae, Susanne A1 - Lukas, Mary Ann A1 - Lyytikainen, Leo-Pekka A1 - Magi, Reedik A1 - Magnusson, Patrik K. E. A1 - Mahajan, Anubha A1 - Martin, Nicholas G. A1 - Martins, Jade A1 - Marz, Winfried A1 - Mascalzoni, Deborah A1 - Matsuda, Koichi A1 - Meisinger, Christa A1 - Meitinger, Thomas A1 - Melander, Olle A1 - Metspalu, Andres A1 - Mikaelsdottir, Evgenia K. A1 - Milaneschi, Yuri A1 - Miliku, Kozeta A1 - Mishra, Pashupati P. A1 - Program, V. A. Million Veteran A1 - Mohlke, Karen L. A1 - Mononen, Nina A1 - Montgomery, Grant W. A1 - Mook-Kanamori, Dennis O. A1 - Mychaleckyj, Josyf C. A1 - Nadkarni, Girish N. A1 - Nalls, Mike A. A1 - Nauck, Matthias A1 - Nikus, Kjell A1 - Ning, Boting A1 - Nolte, Ilja M. A1 - Noordam, Raymond A1 - Olafsson, Isleifur A1 - Oldehinkel, Albertine J. A1 - Orho-Melander, Marju A1 - Ouwehand, Willem H. A1 - Padmanabhan, Sandosh A1 - Palmer, Nicholette D. A1 - Palsson, Runolfur A1 - Penninx, Brenda W. J. H. A1 - Perls, Thomas A1 - Perola, Markus A1 - Pirastu, Mario A1 - Pirastu, Nicola A1 - Pistis, Giorgio A1 - Podgornaia, Anna I. A1 - Polasek, Ozren A1 - Ponte, Belen A1 - Porteous, David J. A1 - Poulain, Tanja A1 - Pramstaller, Peter P. A1 - Preuss, Michael H. A1 - Prins, Bram P. A1 - Province, Michael A. A1 - Rabelink, Ton J. A1 - Raffield, Laura M. A1 - Raitakari, Olli T. A1 - Reilly, Dermot F. A1 - Rettig, Rainer A1 - Rheinberger, Myriam A1 - Rice, Kenneth M. A1 - Ridker, Paul M. A1 - Rivadeneira, Fernando A1 - Rizzi, Federica A1 - Roberts, David J. A1 - Robino, Antonietta A1 - Rossing, Peter A1 - Rudan, Igor A1 - Rueedi, Rico A1 - Ruggiero, Daniela A1 - Ryan, Kathleen A. A1 - Saba, Yasaman A1 - Sabanayagam, Charumathi A1 - Salomaa, Veikko A1 - Salvi, Erika A1 - Saum, Kai-Uwe A1 - Schmidt, Helena A1 - Schmidt, Reinhold A1 - Ben Schottker, A1 - Schulz, Christina-Alexandra A1 - Schupf, Nicole A1 - Shaffer, Christian M. A1 - Shi, Yuan A1 - Smith, Albert V. A1 - Smith, Blair H. A1 - Soranzo, Nicole A1 - Spracklen, Cassandra N. A1 - Strauch, Konstantin A1 - Stringham, Heather M. A1 - Stumvoll, Michael A1 - Svensson, Per O. A1 - Szymczak, Silke A1 - Tai, E-Shyong A1 - Tajuddin, Salman M. A1 - Tan, Nicholas Y. Q. A1 - Taylor, Kent D. A1 - Teren, Andrej A1 - Tham, Yih-Chung A1 - Thiery, Joachim A1 - Thio, Chris H. L. A1 - Thomsen, Hauke A1 - Thorleifsson, Gudmar A1 - Toniolo, Daniela A1 - Tonjes, Anke A1 - Tremblay, Johanne A1 - Tzoulaki, Ioanna A1 - Uitterlinden, Andre G. A1 - Vaccargiu, Simona A1 - Van Dam, Rob M. A1 - Van der Harst, Pim A1 - Van Duijn, Cornelia M. A1 - Edward, Digna R. Velez A1 - Verweij, Niek A1 - Vogelezang, Suzanne A1 - Volker, Uwe A1 - Vollenweider, Peter A1 - Waeber, Gerard A1 - Waldenberger, Melanie A1 - Wallentin, Lars A1 - Wang, Ya Xing A1 - Wang, Chaolong A1 - Waterworth, Dawn M. A1 - Bin Wei, Wen A1 - White, Harvey A1 - Whitfield, John B. A1 - Wild, Sarah H. A1 - Wilson, James F. A1 - Wojczynski, Mary K. A1 - Wong, Charlene A1 - Wong, Tien-Yin A1 - Xu, Liang A1 - Yang, Qiong A1 - Yasuda, Masayuki A1 - Yerges-Armstrong, Laura M. A1 - Zhang, Weihua A1 - Zonderman, Alan B. A1 - Rotter, Jerome I. A1 - Bochud, Murielle A1 - Psaty, Bruce M. A1 - Vitart, Veronique A1 - Wilson, James G. A1 - Dehghan, Abbas A1 - Parsa, Afshin A1 - Chasman, Daniel I. A1 - Ho, Kevin A1 - Morris, Andrew P. A1 - Devuyst, Olivier A1 - Akilesh, Shreeram A1 - Pendergrass, Sarah A. A1 - Sim, Xueling A1 - Boger, Carsten A. A1 - Okada, Yukinori A1 - Edwards, Todd L. A1 - Snieder, Harold A1 - Stefansson, Kari A1 - Hung, Adriana M. A1 - Heid, Iris M. A1 - Scholz, Markus A1 - Teumer, Alexander A1 - Kottgen, Anna A1 - Pattaro, Cristian T1 - A catalog of genetic loci associated with kidney function from analyses of a million individuals JF - Nature genetics N2 - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research. Y1 - 2019 U6 - https://doi.org/10.1038/s41588-019-0407-x SN - 1061-4036 SN - 1546-1718 VL - 51 IS - 6 SP - 957 EP - + PB - Nature Publ. Group CY - New York ER - TY - JOUR A1 - Aarts, Alexander A. A1 - Anderson, Joanna E. A1 - Anderson, Christopher J. A1 - Attridge, Peter R. A1 - Attwood, Angela A1 - Axt, Jordan A1 - Babel, Molly A1 - Bahnik, Stepan A1 - Baranski, Erica A1 - Barnett-Cowan, Michael A1 - Bartmess, Elizabeth A1 - Beer, Jennifer A1 - Bell, Raoul A1 - Bentley, Heather A1 - Beyan, Leah A1 - Binion, Grace A1 - Borsboom, Denny A1 - Bosch, Annick A1 - Bosco, Frank A. A1 - Bowman, Sara D. A1 - Brandt, Mark J. A1 - Braswell, Erin A1 - Brohmer, Hilmar A1 - Brown, Benjamin T. A1 - Brown, Kristina A1 - Bruening, Jovita A1 - Calhoun-Sauls, Ann A1 - Callahan, Shannon P. A1 - Chagnon, Elizabeth A1 - Chandler, Jesse A1 - Chartier, Christopher R. A1 - Cheung, Felix A1 - Christopherson, Cody D. A1 - Cillessen, Linda A1 - Clay, Russ A1 - Cleary, Hayley A1 - Cloud, Mark D. A1 - Cohn, Michael A1 - Cohoon, Johanna A1 - Columbus, Simon A1 - Cordes, Andreas A1 - Costantini, Giulio A1 - Alvarez, Leslie D. Cramblet A1 - Cremata, Ed A1 - Crusius, Jan A1 - DeCoster, Jamie A1 - DeGaetano, Michelle A. A1 - Della Penna, Nicolas A1 - den Bezemer, Bobby A1 - Deserno, Marie K. A1 - Devitt, Olivia A1 - Dewitte, Laura A1 - Dobolyi, David G. A1 - Dodson, Geneva T. A1 - Donnellan, M. Brent A1 - Donohue, Ryan A1 - Dore, Rebecca A. A1 - Dorrough, Angela A1 - Dreber, Anna A1 - Dugas, Michelle A1 - Dunn, Elizabeth W. A1 - Easey, Kayleigh A1 - Eboigbe, Sylvia A1 - Eggleston, Casey A1 - Embley, Jo A1 - Epskamp, Sacha A1 - Errington, Timothy M. A1 - Estel, Vivien A1 - Farach, Frank J. A1 - Feather, Jenelle A1 - Fedor, Anna A1 - Fernandez-Castilla, Belen A1 - Fiedler, Susann A1 - Field, James G. A1 - Fitneva, Stanka A. A1 - Flagan, Taru A1 - Forest, Amanda L. A1 - Forsell, Eskil A1 - Foster, Joshua D. A1 - Frank, Michael C. A1 - Frazier, Rebecca S. A1 - Fuchs, Heather A1 - Gable, Philip A1 - Galak, Jeff A1 - Galliani, Elisa Maria A1 - Gampa, Anup A1 - Garcia, Sara A1 - Gazarian, Douglas A1 - Gilbert, Elizabeth A1 - Giner-Sorolla, Roger A1 - Glöckner, Andreas A1 - Göllner, Lars A1 - Goh, Jin X. A1 - Goldberg, Rebecca A1 - Goodbourn, Patrick T. A1 - Gordon-McKeon, Shauna A1 - Gorges, Bryan A1 - Gorges, Jessie A1 - Goss, Justin A1 - Graham, Jesse A1 - Grange, James A. A1 - Gray, Jeremy A1 - Hartgerink, Chris A1 - Hartshorne, Joshua A1 - Hasselman, Fred A1 - Hayes, Timothy A1 - Heikensten, Emma A1 - Henninger, Felix A1 - Hodsoll, John A1 - Holubar, Taylor A1 - Hoogendoorn, Gea A1 - Humphries, Denise J. A1 - Hung, Cathy O. -Y. A1 - Immelman, Nathali A1 - Irsik, Vanessa C. A1 - Jahn, Georg A1 - Jaekel, Frank A1 - Jekel, Marc A1 - Johannesson, Magnus A1 - Johnson, Larissa G. A1 - Johnson, David J. A1 - Johnson, Kate M. A1 - Johnston, William J. A1 - Jonas, Kai A1 - Joy-Gaba, Jennifer A. A1 - Kappes, Heather Barry A1 - Kelso, Kim A1 - Kidwell, Mallory C. A1 - Kim, Seung Kyung A1 - Kirkhart, Matthew A1 - Kleinberg, Bennett A1 - Knezevic, Goran A1 - Kolorz, Franziska Maria A1 - Kossakowski, Jolanda J. A1 - Krause, Robert Wilhelm A1 - Krijnen, Job A1 - Kuhlmann, Tim A1 - Kunkels, Yoram K. A1 - Kyc, Megan M. A1 - Lai, Calvin K. A1 - Laique, Aamir A1 - Lakens, Daniel A1 - Lane, Kristin A. A1 - Lassetter, Bethany A1 - Lazarevic, Ljiljana B. A1 - LeBel, Etienne P. A1 - Lee, Key Jung A1 - Lee, Minha A1 - Lemm, Kristi A1 - Levitan, Carmel A. A1 - Lewis, Melissa A1 - Lin, Lin A1 - Lin, Stephanie A1 - Lippold, Matthias A1 - Loureiro, Darren A1 - Luteijn, Ilse A1 - Mackinnon, Sean A1 - Mainard, Heather N. A1 - Marigold, Denise C. A1 - Martin, Daniel P. A1 - Martinez, Tylar A1 - Masicampo, E. J. A1 - Matacotta, Josh A1 - Mathur, Maya A1 - May, Michael A1 - Mechin, Nicole A1 - Mehta, Pranjal A1 - Meixner, Johannes A1 - Melinger, Alissa A1 - Miller, Jeremy K. A1 - Miller, Mallorie A1 - Moore, Katherine A1 - Möschl, Marcus A1 - Motyl, Matt A1 - Müller, Stephanie M. A1 - Munafo, Marcus A1 - Neijenhuijs, Koen I. A1 - Nervi, Taylor A1 - Nicolas, Gandalf A1 - Nilsonne, Gustav A1 - Nosek, Brian A. A1 - Nuijten, Michele B. A1 - Olsson, Catherine A1 - Osborne, Colleen A1 - Ostkamp, Lutz A1 - Pavel, Misha A1 - Penton-Voak, Ian S. A1 - Perna, Olivia A1 - Pernet, Cyril A1 - Perugini, Marco A1 - Pipitone, R. Nathan A1 - Pitts, Michael A1 - Plessow, Franziska A1 - Prenoveau, Jason M. A1 - Rahal, Rima-Maria A1 - Ratliff, Kate A. A1 - Reinhard, David A1 - Renkewitz, Frank A1 - Ricker, Ashley A. A1 - Rigney, Anastasia A1 - Rivers, Andrew M. A1 - Roebke, Mark A1 - Rutchick, Abraham M. A1 - Ryan, Robert S. A1 - Sahin, Onur A1 - Saide, Anondah A1 - Sandstrom, Gillian M. A1 - Santos, David A1 - Saxe, Rebecca A1 - Schlegelmilch, Rene A1 - Schmidt, Kathleen A1 - Scholz, Sabine A1 - Seibel, Larissa A1 - Selterman, Dylan Faulkner A1 - Shaki, Samuel A1 - Simpson, William B. A1 - Sinclair, H. Colleen A1 - Skorinko, Jeanine L. M. A1 - Slowik, Agnieszka A1 - Snyder, Joel S. A1 - Soderberg, Courtney A1 - Sonnleitner, Carina A1 - Spencer, Nick A1 - Spies, Jeffrey R. A1 - Steegen, Sara A1 - Stieger, Stefan A1 - Strohminger, Nina A1 - Sullivan, Gavin B. A1 - Talhelm, Thomas A1 - Tapia, Megan A1 - te Dorsthorst, Anniek A1 - Thomae, Manuela A1 - Thomas, Sarah L. A1 - Tio, Pia A1 - Traets, Frits A1 - Tsang, Steve A1 - Tuerlinckx, Francis A1 - Turchan, Paul A1 - Valasek, Milan A1 - Van Aert, Robbie A1 - van Assen, Marcel A1 - van Bork, Riet A1 - van de Ven, Mathijs A1 - van den Bergh, Don A1 - van der Hulst, Marije A1 - van Dooren, Roel A1 - van Doorn, Johnny A1 - van Renswoude, Daan R. A1 - van Rijn, Hedderik A1 - Vanpaemel, Wolf A1 - Echeverria, Alejandro Vasquez A1 - Vazquez, Melissa A1 - Velez, Natalia A1 - Vermue, Marieke A1 - Verschoor, Mark A1 - Vianello, Michelangelo A1 - Voracek, Martin A1 - Vuu, Gina A1 - Wagenmakers, Eric-Jan A1 - Weerdmeester, Joanneke A1 - Welsh, Ashlee A1 - Westgate, Erin C. A1 - Wissink, Joeri A1 - Wood, Michael A1 - Woods, Andy A1 - Wright, Emily A1 - Wu, Sining A1 - Zeelenberg, Marcel A1 - Zuni, Kellylynn T1 - Estimating the reproducibility of psychological science JF - Science N2 - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams. Y1 - 2015 U6 - https://doi.org/10.1126/science.aac4716 SN - 1095-9203 SN - 0036-8075 VL - 349 IS - 6251 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Barcelo-Coblijn, Gwendolyn A1 - Laura Martin, Maria A1 - de Almeida, Rodrigo F. M. A1 - Antonia Noguera-Salva, Maria A1 - Marcilla-Etxenike, Amaia A1 - Guardiola-Serrano, Francisca A1 - Lueth, Anja A1 - Kleuser, Burkhard A1 - Halver, John E. A1 - Escriba, Pablo V. T1 - Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy JF - Proceedings of the National Academy of Sciences of the United States of America N2 - The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor compound, has not yet been fully elucidated. Here, we show that human cancer cells have markedly lower levels of sphingomyelin (SM) than nontumor (MRC-5) cells. In this context, 2OHOA treatment strongly augments SM mass (4.6-fold), restoring the levels found in MRC-5 cells, while a loss of phosphatidylethanolamine and phosphatidylcholine is observed (57 and 30%, respectively). The increased SM mass was due to a rapid and highly specific activation of SM synthases (SMS). This effect appeared to be specific against cancer cells as it did not affect nontumor MRC-5 cells. Therefore, low SM levels are associated with the tumorigenic transformation that produces cancer cells. SM accumulation occurred at the plasma membrane and caused an increase in membrane global order and lipid raft packing in model membranes. These modifications would account for the observed alteration by 2OHOA in the localization of proteins involved in cell apoptosis (Fas receptor) or differentiation (Ras). Importantly, SMS inhibition by D609 diminished 2OHOA effect on cell cycle. Therefore, we propose that the regulation of SMS activity in tumor cells is a critical upstream event in 2OHOA antitumor mechanism, which also explains its specificity for cancer cells, its potency, and the lack of undesired side effects. Finally, the specific activation of SMS explains the ability of this compound to trigger cell cycle arrest, cell differentiation, and autophagy or apoptosis in cancer cells. KW - anticancer KW - membrane-lipid therapy KW - lung cancer KW - membrane lipids Y1 - 2011 U6 - https://doi.org/10.1073/pnas.1115484108 SN - 0027-8424 VL - 108 IS - 49 SP - 19569 EP - 19574 PB - National Acad. of Sciences CY - Washington ER - TY - JOUR A1 - Mantzouki, Evanthia A1 - Lurling, Miquel A1 - Fastner, Jutta A1 - Domis, Lisette Nicole de Senerpont A1 - Wilk-Wozniak, Elzbieta A1 - Koreiviene, Judita A1 - Seelen, Laura A1 - Teurlincx, Sven A1 - Verstijnen, Yvon A1 - Krzton, Wojciech A1 - Walusiak, Edward A1 - Karosiene, Jurate A1 - Kasperoviciene, Jurate A1 - Savadova, Ksenija A1 - Vitonyte, Irma A1 - Cillero-Castro, Carmen A1 - Budzynska, Agnieszka A1 - Goldyn, Ryszard A1 - Kozak, Anna A1 - Rosinska, Joanna A1 - Szelag-Wasielewska, Elzbieta A1 - Domek, Piotr A1 - Jakubowska-Krepska, Natalia A1 - Kwasizur, Kinga A1 - Messyasz, Beata A1 - Pelechata, Aleksandra A1 - Pelechaty, Mariusz A1 - Kokocinski, Mikolaj A1 - Garcia-Murcia, Ana A1 - Real, Monserrat A1 - Romans, Elvira A1 - Noguero-Ribes, Jordi A1 - Parreno Duque, David A1 - Fernandez-Moran, Elisabeth A1 - Karakaya, Nusret A1 - Haggqvist, Kerstin A1 - Demir, Nilsun A1 - Beklioglu, Meryem A1 - Filiz, Nur A1 - Levi, Eti E. A1 - Iskin, Ugur A1 - Bezirci, Gizem A1 - Tavsanoglu, Ulku Nihan A1 - Ozhan, Koray A1 - Gkelis, Spyros A1 - Panou, Manthos A1 - Fakioglu, Ozden A1 - Avagianos, Christos A1 - Kaloudis, Triantafyllos A1 - Celik, Kemal A1 - Yilmaz, Mete A1 - Marce, Rafael A1 - Catalan, Nuria A1 - Bravo, Andrea G. A1 - Buck, Moritz A1 - Colom-Montero, William A1 - Mustonen, Kristiina A1 - Pierson, Don A1 - Yang, Yang A1 - Raposeiro, Pedro M. A1 - Goncalves, Vitor A1 - Antoniou, Maria G. A1 - Tsiarta, Nikoletta A1 - McCarthy, Valerie A1 - Perello, Victor C. A1 - Feldmann, Tonu A1 - Laas, Alo A1 - Panksep, Kristel A1 - Tuvikene, Lea A1 - Gagala, Ilona A1 - Mankiewicz-Boczek, Joana A1 - Yagci, Meral Apaydin A1 - Cinar, Sakir A1 - Capkin, Kadir A1 - Yagci, Abdulkadir A1 - Cesur, Mehmet A1 - Bilgin, Fuat A1 - Bulut, Cafer A1 - Uysal, Rahmi A1 - Obertegger, Ulrike A1 - Boscaini, Adriano A1 - Flaim, Giovanna A1 - Salmaso, Nico A1 - Cerasino, Leonardo A1 - Richardson, Jessica A1 - Visser, Petra M. A1 - Verspagen, Jolanda M. H. A1 - Karan, Tunay A1 - Soylu, Elif Neyran A1 - Maraslioglu, Faruk A1 - Napiorkowska-Krzebietke, Agnieszka A1 - Ochocka, Agnieszka A1 - Pasztaleniec, Agnieszka A1 - Antao-Geraldes, Ana M. A1 - Vasconcelos, Vitor A1 - Morais, Joao A1 - Vale, Micaela A1 - Koker, Latife A1 - Akcaalan, Reyhan A1 - Albay, Meric A1 - Maronic, Dubravka Spoljaric A1 - Stevic, Filip A1 - Pfeiffer, Tanja Zuna A1 - Fonvielle, Jeremy Andre A1 - Straile, Dietmar A1 - Rothhaupt, Karl-Otto A1 - Hansson, Lars-Anders A1 - Urrutia-Cordero, Pablo A1 - Blaha, Ludek A1 - Geris, Rodan A1 - Frankova, Marketa A1 - Kocer, Mehmet Ali Turan A1 - Alp, Mehmet Tahir A1 - Remec-Rekar, Spela A1 - Elersek, Tina A1 - Triantis, Theodoros A1 - Zervou, Sevasti-Kiriaki A1 - Hiskia, Anastasia A1 - Haande, Sigrid A1 - Skjelbred, Birger A1 - Madrecka, Beata A1 - Nemova, Hana A1 - Drastichova, Iveta A1 - Chomova, Lucia A1 - Edwards, Christine A1 - Sevindik, Tugba Ongun A1 - Tunca, Hatice A1 - OEnem, Burcin A1 - Aleksovski, Boris A1 - Krstic, Svetislav A1 - Vucelic, Itana Bokan A1 - Nawrocka, Lidia A1 - Salmi, Pauliina A1 - Machado-Vieira, Danielle A1 - de Oliveira, Alinne Gurjao A1 - Delgado-Martin, Jordi A1 - Garcia, David A1 - Cereijo, Jose Luis A1 - Goma, Joan A1 - Trapote, Mari Carmen A1 - Vegas-Vilarrubia, Teresa A1 - Obrador, Biel A1 - Grabowska, Magdalena A1 - Karpowicz, Maciej A1 - Chmura, Damian A1 - Ubeda, Barbara A1 - Angel Galvez, Jose A1 - Ozen, Arda A1 - Christoffersen, Kirsten Seestern A1 - Warming, Trine Perlt A1 - Kobos, Justyna A1 - Mazur-Marzec, Hanna A1 - Perez-Martinez, Carmen A1 - Ramos-Rodriguez, Eloisa A1 - Arvola, Lauri A1 - Alcaraz-Parraga, Pablo A1 - Toporowska, Magdalena A1 - Pawlik-Skowronska, Barbara A1 - Niedzwiecki, Michal A1 - Peczula, Wojciech A1 - Leira, Manel A1 - Hernandez, Armand A1 - Moreno-Ostos, Enrique A1 - Maria Blanco, Jose A1 - Rodriguez, Valeriano A1 - Juan Montes-Perez, Jorge A1 - Palomino, Roberto L. A1 - Rodriguez-Perez, Estela A1 - Carballeira, Rafael A1 - Camacho, Antonio A1 - Picazo, Antonio A1 - Rochera, Carlos A1 - Santamans, Anna C. A1 - Ferriol, Carmen A1 - Romo, Susana A1 - Miguel Soria, Juan A1 - Dunalska, Julita A1 - Sienska, Justyna A1 - Szymanski, Daniel A1 - Kruk, Marek A1 - Kostrzewska-Szlakowska, Iwona A1 - Jasser, Iwona A1 - Zutinic, Petar A1 - Udovic, Marija Gligora A1 - Plenkovic-Moraj, Andelka A1 - Frak, Magdalena A1 - Bankowska-Sobczak, Agnieszka A1 - Wasilewicz, Michal A1 - Ozkan, Korhan A1 - Maliaka, Valentini A1 - Kangro, Kersti A1 - Grossart, Hans-Peter A1 - Paerl, Hans W. A1 - Carey, Cayelan C. A1 - Ibelings, Bas W. T1 - Temperature effects explain continental scale distribution of cyanobacterial toxins JF - Toxins N2 - Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains. KW - microcystin KW - anatoxin KW - cylindrospermopsin KW - temperature KW - direct effects KW - indirect effects KW - spatial distribution KW - European Multi Lake Survey Y1 - 2018 U6 - https://doi.org/10.3390/toxins10040156 SN - 2072-6651 VL - 10 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Mantzouki, Evanthia A1 - Campbell, James A1 - van Loon, Emiel A1 - Visser, Petra A1 - Konstantinou, Iosif A1 - Antoniou, Maria A1 - Giuliani, Gregory A1 - Machado-Vieira, Danielle A1 - de Oliveira, Alinne Gurjao A1 - Maronic, Dubravka Spoljaric A1 - Stevic, Filip A1 - Pfeiffer, Tanja Zuna A1 - Vucelic, Itana Bokan A1 - Zutinic, Petar A1 - Udovic, Marija Gligora A1 - Plenkovic-Moraj, Andelka A1 - Tsiarta, Nikoletta A1 - Blaha, Ludek A1 - Geris, Rodan A1 - Frankova, Marketa A1 - Christoffersen, Kirsten Seestern A1 - Warming, Trine Perlt A1 - Feldmann, Tonu A1 - Laas, Alo A1 - Panksep, Kristel A1 - Tuvikene, Lea A1 - Kangro, Kersti A1 - Haggqvist, Kerstin A1 - Salmi, Pauliina A1 - Arvola, Lauri A1 - Fastner, Jutta A1 - Straile, Dietmar A1 - Rothhaupt, Karl-Otto A1 - Fonvielle, Jeremy Andre A1 - Grossart, Hans-Peter A1 - Avagianos, Christos A1 - Kaloudis, Triantafyllos A1 - Triantis, Theodoros A1 - Zervou, Sevasti-Kiriaki A1 - Hiskia, Anastasia A1 - Gkelis, Spyros A1 - Panou, Manthos A1 - McCarthy, Valerie A1 - Perello, Victor C. A1 - Obertegger, Ulrike A1 - Boscaini, Adriano A1 - Flaim, Giovanna A1 - Salmaso, Nico A1 - Cerasino, Leonardo A1 - Koreiviene, Judita A1 - Karosiene, Jurate A1 - Kasperoviciene, Jurate A1 - Savadova, Ksenija A1 - Vitonyte, Irma A1 - Haande, Sigrid A1 - Skjelbred, Birger A1 - Grabowska, Magdalena A1 - Karpowicz, Maciej A1 - Chmura, Damian A1 - Nawrocka, Lidia A1 - Kobos, Justyna A1 - Mazur-Marzec, Hanna A1 - Alcaraz-Parraga, Pablo A1 - Wilk-Wozniak, Elzbieta A1 - Krzton, Wojciech A1 - Walusiak, Edward A1 - Gagala, Ilona A1 - Mankiewicz-Boczek, Joana A1 - Toporowska, Magdalena A1 - Pawlik-Skowronska, Barbara A1 - Niedzwiecki, Michal A1 - Peczula, Wojciech A1 - Napiorkowska-Krzebietke, Agnieszka A1 - Dunalska, Julita A1 - Sienska, Justyna A1 - Szymanski, Daniel A1 - Kruk, Marek A1 - Budzynska, Agnieszka A1 - Goldyn, Ryszard A1 - Kozak, Anna A1 - Rosinska, Joanna A1 - Szelag-Wasielewska, Elzbieta A1 - Domek, Piotr A1 - Jakubowska-Krepska, Natalia A1 - Kwasizur, Kinga A1 - Messyasz, Beata A1 - Pelechata, Aleksandra A1 - Pelechaty, Mariusz A1 - Kokocinski, Mikolaj A1 - Madrecka, Beata A1 - Kostrzewska-Szlakowska, Iwona A1 - Frak, Magdalena A1 - Bankowska-Sobczak, Agnieszka A1 - Wasilewicz, Michal A1 - Ochocka, Agnieszka A1 - Pasztaleniec, Agnieszka A1 - Jasser, Iwona A1 - Antao-Geraldes, Ana M. A1 - Leira, Manel A1 - Hernandez, Armand A1 - Vasconcelos, Vitor A1 - Morais, Joao A1 - Vale, Micaela A1 - Raposeiro, Pedro M. A1 - Goncalves, Vitor A1 - Aleksovski, Boris A1 - Krstic, Svetislav A1 - Nemova, Hana A1 - Drastichova, Iveta A1 - Chomova, Lucia A1 - Remec-Rekar, Spela A1 - Elersek, Tina A1 - Delgado-Martin, Jordi A1 - Garcia, David A1 - Luis Cereijo, Jose A1 - Goma, Joan A1 - Carmen Trapote, Mari A1 - Vegas-Vilarrubia, Teresa A1 - Obrador, Biel A1 - Garcia-Murcia, Ana A1 - Real, Monserrat A1 - Romans, Elvira A1 - Noguero-Ribes, Jordi A1 - Parreno Duque, David A1 - Fernandez-Moran, Elisabeth A1 - Ubeda, Barbara A1 - Angel Galvez, Jose A1 - Marce, Rafael A1 - Catalan, Nuria A1 - Perez-Martinez, Carmen A1 - Ramos-Rodriguez, Eloisa A1 - Cillero-Castro, Carmen A1 - Moreno-Ostos, Enrique A1 - Maria Blanco, Jose A1 - Rodriguez, Valeriano A1 - Juan Montes-Perez, Jorge A1 - Palomino, Roberto L. A1 - Rodriguez-Perez, Estela A1 - Carballeira, Rafael A1 - Camacho, Antonio A1 - Picazo, Antonio A1 - Rochera, Carlos A1 - Santamans, Anna C. A1 - Ferriol, Carmen A1 - Romo, Susana A1 - Soria, Juan Miguel A1 - Hansson, Lars-Anders A1 - Urrutia-Cordero, Pablo A1 - Ozen, Arda A1 - Bravo, Andrea G. A1 - Buck, Moritz A1 - Colom-Montero, William A1 - Mustonen, Kristiina A1 - Pierson, Don A1 - Yang, Yang A1 - Verspagen, Jolanda M. H. A1 - Domis, Lisette N. de Senerpont A1 - Seelen, Laura A1 - Teurlincx, Sven A1 - Verstijnen, Yvon A1 - Lurling, Miquel A1 - Maliaka, Valentini A1 - Faassen, Elisabeth J. A1 - Latour, Delphine A1 - Carey, Cayelan C. A1 - Paerl, Hans W. A1 - Torokne, Andrea A1 - Karan, Tunay A1 - Demir, Nilsun A1 - Beklioglu, Meryem A1 - Filiz, Nur A1 - Levi, Eti E. A1 - Iskin, Ugur A1 - Bezirci, Gizem A1 - Tavsanoglu, Ulku Nihan A1 - Celik, Kemal A1 - Ozhan, Koray A1 - Karakaya, Nusret A1 - Kocer, Mehmet Ali Turan A1 - Yilmaz, Mete A1 - Maraslioglu, Faruk A1 - Fakioglu, Ozden A1 - Soylu, Elif Neyran A1 - Yagci, Meral Apaydin A1 - Cinar, Sakir A1 - Capkin, Kadir A1 - Yagci, Abdulkadir A1 - Cesur, Mehmet A1 - Bilgin, Fuat A1 - Bulut, Cafer A1 - Uysal, Rahmi A1 - Koker, Latife A1 - Akcaalan, Reyhan A1 - Albay, Meric A1 - Alp, Mehmet Tahir A1 - Ozkan, Korhan A1 - Sevindik, Tugba Ongun A1 - Tunca, Hatice A1 - Onem, Burcin A1 - Richardson, Jessica A1 - Edwards, Christine A1 - Bergkemper, Victoria A1 - Beirne, Eilish A1 - Cromie, Hannah A1 - Ibelings, Bastiaan W. T1 - Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins JF - Scientific Data N2 - Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment. KW - Climate-change ecology KW - Limnology KW - Water resources Y1 - 2018 U6 - https://doi.org/10.1038/sdata.2018.226 SN - 2052-4463 VL - 5 PB - Nature Publ. Group CY - London ER - TY - GEN A1 - Mantzouki, Evanthia A1 - Lürling, Miquel A1 - Fastner, Jutta A1 - Domis, Lisette Nicole de Senerpont A1 - Wilk-Woźniak, Elżbieta A1 - Koreiviene, Judita A1 - Seelen, Laura A1 - Teurlincx, Sven A1 - Verstijnen, Yvon A1 - Krztoń, Wojciech A1 - Walusiak, Edward A1 - Karosienė, Jūratė A1 - Kasperovičienė, Jūratė A1 - Savadova, Ksenija A1 - Vitonytė, Irma A1 - Cillero-Castro, Carmen A1 - Budzyńska, Agnieszka A1 - Goldyn, Ryszard A1 - Kozak, Anna A1 - Rosińska, Joanna A1 - Szeląg-Wasielewska, Elżbieta A1 - Domek, Piotr A1 - Jakubowska-Krepska, Natalia A1 - Kwasizur, Kinga A1 - Messyasz, Beata A1 - Pełechata, Aleksandra A1 - Pełechaty, Mariusz A1 - Kokocinski, Mikolaj A1 - García-Murcia, Ana A1 - Real, Monserrat A1 - Romans, Elvira A1 - Noguero-Ribes, Jordi A1 - Duque, David Parreño A1 - Fernández-Morán, Elísabeth A1 - Karakaya, Nusret A1 - Häggqvist, Kerstin A1 - Beklioğlu, Meryem A1 - Filiz, Nur A1 - Levi, Eti E. A1 - Iskin, Uğur A1 - Bezirci, Gizem A1 - Tavşanoğlu, Ülkü Nihan A1 - Özhan, Koray A1 - Gkelis, Spyros A1 - Panou, Manthos A1 - Fakioglu, Özden A1 - Avagianos, Christos A1 - Kaloudis, Triantafyllos A1 - Çelik, Kemal A1 - Yilmaz, Mete A1 - Marcé, Rafael A1 - Catalán, Nuria A1 - Bravo, Andrea G. A1 - Buck, Moritz A1 - Colom-Montero, William A1 - Mustonen, Kristiina A1 - Pierson, Don A1 - Yang, Yang A1 - Raposeiro, Pedro M. A1 - Gonçalves, Vítor A1 - Antoniou, Maria G. A1 - Tsiarta, Nikoletta A1 - McCarthy, Valerie A1 - Perello, Victor C. A1 - Feldmann, Tõnu A1 - Laas, Alo A1 - Panksep, Kristel A1 - Tuvikene, Lea A1 - Gagala, Ilona A1 - Mankiewicz-Boczek, Joana A1 - Yağcı, Meral Apaydın A1 - Çınar, Şakir A1 - Çapkın, Kadir A1 - Yağcı, Abdulkadir A1 - Cesur, Mehmet A1 - Bilgin, Fuat A1 - Bulut, Cafer A1 - Uysal, Rahmi A1 - Obertegger, Ulrike A1 - Boscaini, Adriano A1 - Flaim, Giovanna A1 - Salmaso, Nico A1 - Cerasino, Leonardo A1 - Richardson, Jessica A1 - Visser, Petra M. A1 - Verspagen, Jolanda M. H. A1 - Karan, Tünay A1 - Soylu, Elif Neyran A1 - Maraşlıoğlu, Faruk A1 - Napiórkowska-Krzebietke, Agnieszka A1 - Ochocka, Agnieszka A1 - Pasztaleniec, Agnieszka A1 - Antão-Geraldes, Ana M. A1 - Vasconcelos, Vitor A1 - Morais, João A1 - Vale, Micaela A1 - Köker, Latife A1 - Akçaalan, Reyhan A1 - Albay, Meriç A1 - Maronić, Dubravka Špoljarić A1 - Stević, Filip A1 - Pfeiffer, Tanja Žuna A1 - Fonvielle, Jeremy Andre A1 - Straile, Dietmar A1 - Rothhaupt, Karl-Otto A1 - Hansson, Lars-Anders A1 - Urrutia-Cordero, Pablo A1 - Bláha, Luděk A1 - Geriš, Rodan A1 - Fránková, Markéta A1 - Koçer, Mehmet Ali Turan A1 - Alp, Mehmet Tahir A1 - Remec-Rekar, Spela A1 - Elersek, Tina A1 - Triantis, Theodoros A1 - Zervou, Sevasti-Kiriaki A1 - Hiskia, Anastasia A1 - Haande, Sigrid A1 - Skjelbred, Birger A1 - Madrecka, Beata A1 - Nemova, Hana A1 - Drastichova, Iveta A1 - Chomova, Lucia A1 - Edwards, Christine A1 - Sevindik, Tuğba Ongun A1 - Tunca, Hatice A1 - Önem, Burçin A1 - Aleksovski, Boris A1 - Krstić, Svetislav A1 - Vucelić, Itana Bokan A1 - Nawrocka, Lidia A1 - Salmi, Pauliina A1 - Machado-Vieira, Danielle A1 - Oliveira, Alinne Gurjão De A1 - Delgado-Martín, Jordi A1 - García, David A1 - Cereijo, Jose Luís A1 - Gomà, Joan A1 - Trapote, Mari Carmen A1 - Vegas-Vilarrúbia, Teresa A1 - Obrador, Biel A1 - Grabowska, Magdalena A1 - Karpowicz, Maciej A1 - Chmura, Damian A1 - Úbeda, Bárbara A1 - Gálvez, José Ángel A1 - Özen, Arda A1 - Christoffersen, Kirsten Seestern A1 - Warming, Trine Perlt A1 - Kobos, Justyna A1 - Mazur-Marzec, Hanna A1 - Pérez-Martínez, Carmen A1 - Ramos-Rodríguez, Eloísa A1 - Arvola, Lauri A1 - Alcaraz-Párraga, Pablo A1 - Toporowska, Magdalena A1 - Pawlik-Skowronska, Barbara A1 - Niedźwiecki, Michał A1 - Pęczuła, Wojciech A1 - Leira, Manel A1 - Hernández, Armand A1 - Moreno-Ostos, Enrique A1 - Blanco, José María A1 - Rodríguez, Valeriano A1 - Montes-Pérez, Jorge Juan A1 - Palomino, Roberto L. A1 - Rodríguez-Pérez, Estela A1 - Carballeira, Rafael A1 - Camacho, Antonio A1 - Picazo, Antonio A1 - Rochera, Carlos A1 - Santamans, Anna C. A1 - Ferriol, Carmen A1 - Romo, Susana A1 - Soria, Juan Miguel A1 - Dunalska, Julita A1 - Sieńska, Justyna A1 - Szymański, Daniel A1 - Kruk, Marek A1 - Kostrzewska-Szlakowska, Iwona A1 - Jasser, Iwona A1 - Žutinić, Petar A1 - Udovič, Marija Gligora A1 - Plenković-Moraj, Anđelka A1 - Frąk, Magdalena A1 - Bańkowska-Sobczak, Agnieszka A1 - Wasilewicz, Michał A1 - Özkan, Korhan A1 - Maliaka, Valentini A1 - Kangro, Kersti A1 - Grossart, Hans-Peter A1 - Paerl, Hans W. A1 - Carey, Cayelan C. A1 - Ibelings, Bas W. T1 - Temperature effects explain continental scale distribution of cyanobacterial toxins T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1105 KW - microcystin KW - anatoxin KW - cylindrospermopsin KW - temperature KW - direct effects KW - indirect effects KW - spatial distribution KW - European Multi Lake Survey Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427902 SN - 1866-8372 IS - 1105 ER - TY - JOUR A1 - Toy, Virginia Gail A1 - Sutherland, Rupert A1 - Townend, John A1 - Allen, Michael J. A1 - Becroft, Leeza A1 - Boles, Austin A1 - Boulton, Carolyn A1 - Carpenter, Brett A1 - Cooper, Alan A1 - Cox, Simon C. A1 - Daube, Christopher A1 - Faulkner, D. R. A1 - Halfpenny, Angela A1 - Kato, Naoki A1 - Keys, Stephen A1 - Kirilova, Martina A1 - Kometani, Yusuke A1 - Little, Timothy A1 - Mariani, Elisabetta A1 - Melosh, Benjamin A1 - Menzies, Catriona D. A1 - Morales, Luiz A1 - Morgan, Chance A1 - Mori, Hiroshi A1 - Niemeijer, Andre A1 - Norris, Richard A1 - Prior, David A1 - Sauer, Katrina A1 - Schleicher, Anja Maria A1 - Shigematsu, Norio A1 - Teagle, Damon A. H. A1 - Tobin, Harold A1 - Valdez, Robert A1 - Williams, Jack A1 - Yeo, Samantha A1 - Baratin, Laura-May A1 - Barth, Nicolas A1 - Benson, Adrian A1 - Boese, Carolin A1 - Célérier, Bernard A1 - Chamberlain, Calum J. A1 - Conze, Ronald A1 - Coussens, Jamie A1 - Craw, Lisa A1 - Doan, Mai-Linh A1 - Eccles, Jennifer A1 - Grieve, Jason A1 - Grochowski, Julia A1 - Gulley, Anton A1 - Howarth, Jamie A1 - Jacobs, Katrina A1 - Janku-Capova, Lucie A1 - Jeppson, Tamara A1 - Langridge, Robert A1 - Mallyon, Deirdre A1 - Marx, Ray A1 - Massiot, Cécile A1 - Mathewson, Loren A1 - Moore, Josephine A1 - Nishikawa, Osamu A1 - Pooley, Brent A1 - Pyne, Alex A1 - Savage, Martha K. A1 - Schmitt, Doug A1 - Taylor-Offord, Sam A1 - Upton, Phaedra A1 - Weaver, Konrad C. A1 - Wiersberg, Thomas A1 - Zimmer, Martin T1 - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand JF - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG N2 - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled. KW - Alpine Fault KW - New Zealand KW - scientific drilling KW - mylonite KW - cataclasite Y1 - 2017 U6 - https://doi.org/10.1080/00288306.2017.1375533 SN - 0028-8306 SN - 1175-8791 VL - 60 IS - 4 SP - 497 EP - 518 PB - Taylor & Francis CY - Abingdon ER - TY - CHAP A1 - Jacqmin, Julien A1 - Özdemir, Paker Doğu A1 - Fell Kurban, Caroline A1 - Tunç Pekkan, Zelha A1 - Koskinen, Johanna A1 - Suonpää, Maija A1 - Seng, Cheyvuth A1 - Carlon, May Kristine Jonson A1 - Gayed, John Maurice A1 - Cross, Jeffrey S. A1 - Langseth, Inger A1 - Jacobsen, Dan Yngve A1 - Haugsbakken, Halvdan A1 - Bethge, Joseph A1 - Serth, Sebastian A1 - Staubitz, Thomas A1 - Wuttke, Tobias A1 - Nordemann, Oliver A1 - Das, Partha-Pratim A1 - Meinel, Christoph A1 - Ponce, Eva A1 - Srinath, Sindhu A1 - Allegue, Laura A1 - Perach, Shai A1 - Alexandron, Giora A1 - Corti, Paola A1 - Baudo, Valeria A1 - Turró, Carlos A1 - Moura Santos, Ana A1 - Nilsson, Charlotta A1 - Maldonado-Mahauad, Jorge A1 - Valdiviezo, Javier A1 - Carvallo, Juan Pablo A1 - Samaniego-Erazo, Nicolay A1 - Poce, Antonella A1 - Re, Maria Rosaria A1 - Valente, Mara A1 - Karp Gershon, Sa’ar A1 - Ruipérez-Valiente, José A. A1 - Despujol, Ignacio A1 - Busquets, Jaime A1 - Kerr, John A1 - Lorenz, Anja A1 - Schön, Sandra A1 - Ebner, Martin A1 - Wittke, Andreas A1 - Beirne, Elaine A1 - Nic Giolla Mhichíl, Mairéad A1 - Brown, Mark A1 - Mac Lochlainn, Conchúr A1 - Topali, Paraskevi A1 - Chounta, Irene-Angelica A1 - Ortega-Arranz, Alejandro A1 - Villagrá-Sobrino, Sara L. A1 - Martínez-Monés, Alejandra A1 - Blackwell, Virginia Katherine A1 - Wiltrout, Mary Ellen A1 - Rami Gaddem, Mohamed A1 - Hernández Reyes, César Augusto A1 - Nagahama, Toru A1 - Buchem, Ilona A1 - Okatan, Ebru A1 - Khalil, Mohammad A1 - Casiraghi, Daniela A1 - Sancassani, Susanna A1 - Brambilla, Federica A1 - Mihaescu, Vlad A1 - Andone, Diana A1 - Vasiu, Radu A1 - Şahin, Muhittin A1 - Egloffstein, Marc A1 - Bothe, Max A1 - Rohloff, Tobias A1 - Schenk, Nathanael A1 - Schwerer, Florian A1 - Ifenthaler, Dirk A1 - Hense, Julia A1 - Bernd, Mike ED - Meinel, Christoph ED - Staubitz, Thomas ED - Schweiger, Stefanie ED - Friedl, Christian ED - Kiers, Janine ED - Ebner, Martin ED - Lorenz, Anja ED - Ubachs, George ED - Mongenet, Catherine ED - Ruipérez-Valiente, José A. ED - Cortes Mendez, Manoel T1 - EMOOCs 2021 N2 - From June 22 to June 24, 2021, Hasso Plattner Institute, Potsdam, hosted the seventh European MOOC Stakeholder Summit (EMOOCs 2021) together with the eighth ACM Learning@Scale Conference. Due to the COVID-19 situation, the conference was held fully online. The boost in digital education worldwide as a result of the pandemic was also one of the main topics of this year’s EMOOCs. All institutions of learning have been forced to transform and redesign their educational methods, moving from traditional models to hybrid or completely online models at scale. The learnings, derived from practical experience and research, have been explored in EMOOCs 2021 in six tracks and additional workshops, covering various aspects of this field. In this publication, we present papers from the conference’s Experience Track, the Policy Track, the Business Track, the International Track, and the Workshops. KW - e-learning KW - microcredential KW - MOOC KW - digital education KW - experience KW - online course design KW - online course creation KW - higher education Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-510300 SN - 978-3-86956-512-5 PB - Universitätsverlag Potsdam CY - Potsdam ER -